Therapy Patents (Class 378/65)
  • Patent number: 10967200
    Abstract: A method for delivering radiation treatment may include defining a preliminary trajectory including a plurality of control points. Each control point may be associated with position parameters of a gantry and a couch. The method may also include generating a treatment plan based on the preliminary trajectory by optimizing an intensity and position parameters of a collimator and MLC leaves for each control point. The method may also include decomposing the treatment plan into a delivery trajectory including the plurality of control points. Each of the plurality of control points may be further associated with the optimized intensity, the optimized position parameters of the collimator and the MLC leaves, an output rate, and a motion parameter of each of the gantry, the couch, the collimator, and the MLC leaves. The method may further include instructing a radiation delivery device to deliver the treatment plan according to the delivery trajectory.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: April 6, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Johannes Stahl, Jonathan Maltz
  • Patent number: 10960230
    Abstract: The present invention features calibration methods for radiotherapy treatment plans. An image-guided radiotherapy system for tumor treatment featuring a hypoxic-region-focused (HRF) radiation dose is calibrated using a phantom. The treatment plans may also feature a boosted dose to the resistance region of the tumor. The HRF radiation dose may be greater than 120% of a predetermined prescribed radiation dose for the tumor.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: March 30, 2021
    Inventor: Nam P. Nguyen
  • Patent number: 10940330
    Abstract: A method of calculating radiation dose includes dosimetric projection of a collimator geometry. The method includes defining a three-dimensional (3D) geometry of a collimating device which defines an aperture configured to allow a radiation beam passing through, projecting the collimating device along the radiation beam into a two-dimensional (2D) geometry in a plane, calculating dosimetric opacity values of the collimating device at locations adjacent to the aperture based on the 3D geometry of the collimating device, and calculating transport of the radiation beam through the collimating device based on the 2D geometry projected in the plane and using the dosimetric opacity values of the collimating device at the locations adjacent to the aperture.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: March 9, 2021
    Assignee: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
    Inventors: Timo Ikonen, Christopher Boylan, Ari Harju, Petri Hiltunen, Juha Kauppinen, Petri Kokkonen, Viljo Petaja, Marko T Rusanen, Sami P Siljamaki, Tuomas E Torsti, Esa Kuusela, Antti Karjalainen
  • Patent number: 10932732
    Abstract: Provided is a radiation shielding device according to various embodiments. The radiation shielding device includes: a body structure forming a receiving space receiving a user's body part, wherein a through passage penetrating an inside of the body structure is formed in the body structure; a shielding unit positioned to reciprocatively move along the through passage, wherein a shielding pad configured to shield the radiation is included in a portion of the shielding unit; and a driver configured to transfer a driving force to the shielding unit to cause the shielding unit to reciprocatively move.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: March 2, 2021
    Assignee: Samsung Life Public Welfare Foundation
    Inventors: Sang Hun Kim, Sung Ryong Kim, Pyoung Jeon, Won Hong Cho
  • Patent number: 10929990
    Abstract: There are provided a registration apparatus, method, and program capable of performing high-speed registration between three-dimensional images included in imaging series included in different examinations. An accessory information acquisition unit acquires, from each of two examinations including a plurality of imaging series including three-dimensional images each of which is configured to include a plurality of tomographic images, accessory information regarding the three-dimensional images. A series selection unit selects one imaging series from each of the two examinations based on the accessory information. A registration unit performs registration between the three-dimensional images included in the imaging series of the two examinations based on images included in the selected imaging series and acquires a result of the registration as a registration result between the two examinations.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: February 23, 2021
    Assignee: FUJIFILM Corporation
    Inventor: Ryoji Sasada
  • Patent number: 10929976
    Abstract: A method and apparatus for assessing image registration. The method comprises obtaining image datasets for the first and second medical images and registration data representing the registration from the first medical image to the second medical image, collating use-case information for the image registration, deriving a set of at least one measurement and assessment criteria therefor based at least partly on the collated use-case information, performing the at least one measurement on at least one of the obtained image datasets and the obtained registration data to derive at least one measurement value, applying the assessment criteria for the at least one measurement to the at least one measurement value to derive at least one assessment result, and outputting an indication of the at least one assessment result.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: February 23, 2021
    Assignee: Mirada Medical Limited, LLC
    Inventors: Mark Gooding, Timor Kadir
  • Patent number: 10926106
    Abstract: A method and system supports pre-positioning a patient for treatment by radiotherapy or radiosurgery. The disclosed method encompasses comparing an image of a reference structure having a known position relative to an anatomical body part of a patient, such as a live thermal/infrared image of the reference structure, to a predetermined medical image of the reference structure associated with a known position relative to a reference position, such as a known isocenter of a radiotherapy or radiosurgery apparatus. On that basis, it is determined whether the reference structure has moved relative to the reference position. A decision may be made to determine whether the reference structure and therefore the patient has been correctly positioned and/or kept in his desired position relative to a treatment device, and to compensate for any possible positional deviation by moving the patient.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 23, 2021
    Assignee: BRAINLAB AG
    Inventors: Kajetan Berlinger, Hagen Kaiser
  • Patent number: 10922856
    Abstract: A method for correcting projection images in CT image reconstruction is provided. The method may include obtaining a plurality of projection images of a subject. Each of the plurality of projection images may correspond to one of the plurality of gantry angles. The method may further include correcting a first projection image of the plurality of projection images according to a process for generating a corrected projection image. The process may include performing, based on the first projection image and a second projection image of the plurality of projection images, a first correction on the first projection image to generate a preliminary corrected first projection image. The process may also include performing, based on at least part of the preliminary corrected first projection image, a second correction on the preliminary corrected first projection image to generate a corrected first projection image corresponding to the first gantry angle.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: February 16, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Hongcheng Yang, Jianwei Zhu, Haining Sun, Jonathan Maltz
  • Patent number: 10912951
    Abstract: A radiation-treatment plan that comprises a plurality of dose-delivery fractions can be optimized by using fraction dose objectives and at least one other, different dose objective. This use of fraction dose objectives can comprise accumulating doses delivered in previous dose-delivery fractions. The other, different dose objective can comprise a remaining total dose objective, a predictive dose objective, or some other dose objective of choice. An existing radiation-treatment plan having a corresponding resultant quality and that is defined, at least in part, by at least one delivery parameter can be re-optimized by specifying at least one constraint as regards that delivery parameter as a function, at least in part, of that resultant quality and then applying that constraint when re-optimizing the existing radiation-treatment plan.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: February 9, 2021
    Assignee: Varian Medical Systems International AG
    Inventors: Janne I. Nord, Jarkko Y. Peltola, Juha Kauppinen
  • Patent number: 10898730
    Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: January 26, 2021
    Assignees: Varian Medical Systems International AG, Varian Medical Systems, Inc
    Inventors: Christel Smith, Corey Zankowski, Jan Timmer, Wolfgang Kaissl, Deepak Khuntia, Eric Abel, Josh Star-Lack, Camille Noel
  • Patent number: 10898158
    Abstract: A phantom setup and source-to-surface distance (SSD) verification method uses radiation images. In an exemplary method, a phantom is positioned on a support relative to a radiation source such that a surface of the phantom is horizontally leveled at or approximate to a desired value of SSD. The radiation source is then positioned at a gantry angle predetermined at least based on the desired value of SSD such that a ray of radiation from the radiation source aligns with a horizontal surface located at the desired value of SSD. An image is acquired using radiation from the radiation source at the predetermined gantry angle. Verification is performed to confirm, based on an analysis of the image, if the surface of the phantom is positioned at the desired value of SSD.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: January 26, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Magdalena Constantin, HsinLu Hsu
  • Patent number: 10894315
    Abstract: A robot controller comprising a processor that is configured to execute computer-executable instructions so as to controls a robot including an arm capable of moving at least one of a target object and a discharger capable of discharging a discharge object to the target object, wherein the processor is configured to use a first position based on a jig removably attached to the discharger to generate teaching information on a position of the arm.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: January 19, 2021
    Inventors: Yoshito Miyamoto, Tsuguya Kojima, Toshiyuki Ishigaki
  • Patent number: 10888714
    Abstract: Magnetic resonance (MR) guided radiation therapy (MRgRT) enables control over the delivery of radiation based on patient motion indicated by MR imaging (MRI) images captured during radiation delivery. A method for MRgRT includes: simultaneously using one or more radiation therapy heads to deliver radiation and an MRI system to perform MRI; using a processor to determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspending the delivery of radiation.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: January 12, 2021
    Assignee: VIEWRAY TECHNOLOGIES, INC.
    Inventors: James F. Dempsey, Iwan Kawrykow
  • Patent number: 10881875
    Abstract: An achievability estimate is computed for an intensity modulated radiation therapy (IMRT) geometry (32) including a target volume, an organ at risk (OAR), and at least one radiation beam. Namely, a geometric complexity (GC) metric is computed for the IMRT geometry that compares a number NT of beamlets of the at least one radiation beam available in the IMRT geometry for irradiating the target volume and a number n of these beamlets that also pass through the OAR. A GC metric ratio is computed of the GC metric for the IMRT geometry and the GC metric for a reference IMRT geometry for which an IMRT plan is achievable. If the clinician is satisfied with this estimate then optimization (38) of an IMRT plan for the IMRT geometry (32) is performed. Alternatively, a reference IMRT geometry is selected by comparing the GC metric with GC metrics of past IMRT plans.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 5, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Vaitheeswaran Ranganathan, Prashant Kumar, Karl Antonin Bzdusek
  • Patent number: 10881876
    Abstract: The present disclosure provides a radiation method for radiating a fluence map having a zero-fluence region under a movement of MLC (Multi-Leaf Collimator) includes a determining step of determining at least one basic fluence map from the fluence map. The basic fluence map includes a first non-zero fluence region and a second non-fluence region having the zero-fluence region therebetween. The radiation method includes a first radiating step including radiating the first non-zero fluence region, along with moving a first group of leaf pairs and moving a vertical jaw to shade the first group of leaf pairs, and a second radiating step including radiating the second non-zero fluence region, along with moving a second group of leaf pairs and withdrawing the vertical jaw to expose the second group of leaf pairs.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: January 5, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventor: Weiyuan Wang
  • Patent number: 10881880
    Abstract: A computer program product, method, system and device that acquires, by a radiation detector, exit radiation measurement information during delivery of patient treatment. Patient anatomy information is also received and a radiation detector response calibration is determined utilizing at least the exit radiation measurement information, the patient anatomy information, and at least a portion of a radiation treatment plan.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: January 5, 2021
    Assignee: SUN NUCLEAR CORPORATION
    Inventors: Amir Ramezanzadeh Moghadam, Jakub Kozelka
  • Patent number: 10886026
    Abstract: This disclosure relates generally to treatment management systems, which may include a clinical database for storing therapeutic protocols. The system may also include a treatment engine operatively connected to the clinical database. The treatment engine may obtain diagnostic information and select a first plurality of therapeutic protocols from the clinical database based on the obtained diagnostic information and reference protocol data. The treatment engine may calculate a treatment efficacy probability for each protocol using the reference protocol data. The treatment engine may develop a first treatment plan and evaluate intermediate data indicating an altered patient state due to the first treatment plan. The treatment engine may select, based on reference protocol data and adaptive protocol data, a second treatment plan using a second plurality of therapeutic protocols.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: January 5, 2021
    Assignee: Elekta, Inc.
    Inventors: Johannes Ferdinand Van Der Koijk, Scot Evan Hogan, Colin Raymond Winfield, Alexis Nicolaas Thomas Jozef Kotte
  • Patent number: 10881877
    Abstract: An apparatus includes: a processor configured for obtaining a first image that corresponds with a first multi-leaf collimator (MLC) configuration, wherein the first image is generated when the MLC is stationary, obtaining a second image that corresponds with a second MLC configuration, wherein the second image is generated when the MLC and/or another component of a radiation machine is being operated to track a motion, and performing an analysis based at least in part on the first image and the second image to obtain a result; and a non-transitory medium for storing the result.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: January 5, 2021
    Inventors: Stefan G. Scheib, Christof Baltes, Kristijan Macek
  • Patent number: 10863946
    Abstract: In nuclear medical imaging, respiratory motion is corrected. Rather than pairwise estimation of motion from projection views, a sequence-based technique is used to jointly estimate parameters for a motion model across many projection views. In one approach, this sequence-based method is iteratively solved with a maximum likelihood objective function incorporating the motion model. A surrogate respiration signal is used to gate for the joint estimation and used to convert gated motion parameters to temporal motion parameters.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: December 15, 2020
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: James Chester Sanders, III, Alexander Hans Vija
  • Patent number: 10857384
    Abstract: Streamlined and partially automated methods of setting normal tissue objectives in radiation treatment planning are provided. These methods may be applied to multiple-target cases as well as single-target cases. The methods can impose one or more target-specific dose falloff constraints around each target, taking into account geometric characteristics of each target such as target volume and shape. In some embodiments, methods can also take into account a planner's preferences for target dose homogeneity. In some embodiments, methods can generate additional dose falloff constraints in locations between two targets where dose bridging is likely to occur.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: December 8, 2020
    Assignee: Varian Medical Systems International AG
    Inventors: Santtu Ollila, Mikko Vainio, Jarkko Peltola, Janne Nord
  • Patent number: 10857391
    Abstract: A method may include acquiring a first image including a target point and a first reference point, the target point corresponding to at least one part of a subject, the first reference point corresponding to a first marker disposed on the couch of the medical device; determining a first spatial position of the first marker, the first spatial position corresponding to a first working position of the couch; determining a first spatial position of the at least one part of the subject based on the first image and the first spatial position of the first marker; determining a second spatial position of the first marker, the second spatial position corresponding to a second working position of the couch; determining a second spatial position of the at least one part of the subject based on the second spatial position of the first marker and the first spatial position of the at least one part of the subject.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: December 8, 2020
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Johannes N Stahl, Supratik Bose, Li Wang
  • Patent number: 10857392
    Abstract: To overcome the difficulties inherent in conventional proton therapy systems, new techniques are described herein for synchronizing the application of proton radiation with the periodic movement of a target area. In an embodiment, a method is provided that combines multiple rescans of a spot scanning proton beam while monitoring the periodic motion of the target area, and aligning the applications of the proton beam with parameters of the periodic motion. For example, the direction(s) and frequency of the periodic motion may be monitored, and the timing, dose rate, and/or scanning direction and spot sequence of the beam can be adjusted to align with phases in the periodic motion.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: December 8, 2020
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GmbH
    Inventors: Markus Bach, Isabel Huth, Juergen Heese, Franko Piskulich, Lei Dong
  • Patent number: 10850120
    Abstract: A clinical goal for radiation treatment of a patient is set. A dose prediction model is selected from a number of dose prediction models based on the clinical goal. A radiation treatment plan is then generated for the patient using the dose prediction model that was selected based on the clinical goal.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: December 1, 2020
    Assignee: Varian Medical Systems International AG
    Inventors: Hannu Laaksonen, Esa Kuusela, Janne Nord, Joakim Pyyry, Perttu Niemela
  • Patent number: 10850124
    Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: December 1, 2020
    Assignees: Varian Medical Systems International, AG, Varian Medical Systems, Inc.
    Inventors: Reynald Vanderstraeten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
  • Patent number: 10854339
    Abstract: Systems and methods are disclosed for associating medical images with a patient. One method includes: receiving two or more medical images of patient anatomy in an electronic storage medium; generating an anatomical model for each of the received medical images; comparing the generated anatomical models; determining a score assessing the likelihood that the two or more medical images belong to the same patient, using the comparison of the generated anatomical models; and outputting the score to an electronic storage medium or display.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 1, 2020
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Christopher K. Zarins, Edward Karl Hahn, III, Ying Bai, Sethuraman Sankaran, Peter Kersten Petersen, Michiel Schaap
  • Patent number: 10842456
    Abstract: A method for determining an alignment between at least two bone parts of an elongated bone system of a patient includes recording a plurality of partially spatially overlapping projection images by a recording system of an x-ray device during a translational movement of the x-ray device or the recording system in a direction of or parallel to a longitudinal axis of the bone system. Tomosynthesis image data of the bone parts is reconstructed from the recorded projection images, and an alignment angle between the at least two bone parts is determined or estimated at least partially based on the reconstructed tomosynthesis image data and/or the plurality of projection images.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 24, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Alexander Gemmel, Gerhard Kleinszig, Björn Kreher, Benedict Swartman, Wei Wei, Markus Weiten, Qiao Yang
  • Patent number: 10835764
    Abstract: A function/process of recording marker position data and spot data is provided. The marker position data includes position information of a marker 29 measured for tumor tracking irradiation and information on time of execution of X-ray imaging. The spot data includes information on time of irradiation of each spot, a delivered irradiation position, and a delivered irradiation amount. The marker position data and the spot data are synchronized based on the time information, and by using the marker position data and the spot data upon spot irradiation, a delivered dose distribution of proton irradiation is calculated. With this configuration, it is possible to take the influence of interplay effect into consideration, and it is possible to support to make more appropriate determination upon replanning of a treatment plan.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 17, 2020
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yusuke Fujii, Taeko Matsuura, Yuka Matsuzaki, Kikuo Umegaki, Hiroki Shirato, Hidenori Koyano, Takahiro Yamada, Rintarou Fujimoto
  • Patent number: 10838077
    Abstract: A device for determining an ionizing radiation dose deposited by a medical imaging apparatus during a radiological examination of a patient includes at least one measurement probe comprising at least one optical probe defining two exit ends, the optical probe comprising at least one active section made from a scintillator and intended to emit photons under the effect of incident ionizing radiation and at least two transport sections that are placed on either side of the active section and configured to transport the photons emitted by the active section to the exit ends; at least one detection system comprising at least two photodetectors, each photodetector being connected to one respective exit end of the optical probe to receive and count the photons received from the exit end; and at least one processing module configured to determine the deposited dose on the basis of the measurements carried out by the photodetectors.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: November 17, 2020
    Assignee: Fibermetrix
    Inventors: Mèlodie Munier, Till Sohier, Fayçal Torche, Fanny Carbillet
  • Patent number: 10824925
    Abstract: Implantable transponders comprising no ferromagnetic parts for use in medical implants are disclosed herein. Such transponders may assist in preventing interference of transponders with medical imaging technologies. Such transponders may optionally be of a small size, and may assist in collecting and transmitting data and information regarding implanted medical devices. Methods of using such transponders, readers for detecting such transponders, and methods for using such readers are also described.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: November 3, 2020
    Assignee: Establishment Labs S.A.
    Inventors: Randolph Keith Geissler, Rudy A. Mazzocchi, Juan José Chacón Quirós, Steven A. Lewis
  • Patent number: 10825639
    Abstract: An x-ray device is for creation of high-energy x-ray radiation. In an embodiment, the x-ray device includes a linear accelerator. The linear accelerator, for creation of x-ray radiation, is embodied so as to create an electron beam directed onto a target, of which the kinetic energy per electron amounts to at least 1 MeV. In an embodiment, the x-ray device further includes a beam limiting device, arranged in the beam path of the electron beam between linear accelerator and the target, including an edge region surrounding a beam limiting device opening. A material thickness of the edge region, in a propagation direction of the accelerated electron beam emerging from the linear accelerator, amounting to less than 10% of the average reach of electrons of the created kinetic energy in the material of the edge region.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: November 3, 2020
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Martin Koschmieder, Marvin Moeller, Sven Mueller, Stefan Willing
  • Patent number: 10814143
    Abstract: A database stores pre-calculated solutions each of which defines a radiation therapy treatment plan for a treatment volume associated with at least one target and at least one organ-at-risk. The pre-calculated solutions are divided into at least two groups each of which includes at least one pre-calculated solution. The pre-calculated solutions in a given group represent radiation therapy treatment plans which share a common beam configuration. A radiation therapy treatment plan (sc) is established based on the pre-calculated solutions as follows. A first user interface receives operator commands specifying criteria for selecting radiation therapy treatment plans from the database, the criteria defining a set of parameters for the treatment volume. In particular, the operator commands jointly specify criteria for selecting radiation therapy treatment plans from more than one of the at least two groups.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: October 27, 2020
    Assignee: RaySearch Laboratories AB
    Inventor: Björn Hårdemark
  • Patent number: 10792513
    Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: October 6, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Bush, Michael J. Hadsell, Christopher Locke, Lei Xing
  • Patent number: 10780297
    Abstract: Disclosed is a method for determining a positional pattern of an irradiation unit for irradiating a patient with treatment radiation. Optimal order data describing an order of the irradiation unit positions for which the statistical value is optimal is determined. The optimal order data is determined based on irradiation unit position data describing irradiation unit positions of the irradiation unit for which the imaging device has a free viewing direction onto the position of the patient, position orders data describing all possible orders of the irradiation unit positions for which the imaging device has a free viewing direction onto the position of the patient, and intersection angle data describing a statistical quantity of the intersection angles between free viewing directions of the imaging unit for irradiation unit positions which are immediately subsequent in the order described by the position orders data.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 22, 2020
    Assignee: BRAINLAB AG
    Inventors: Kajetan Berlinger, Hagen Kaiser
  • Patent number: 10773101
    Abstract: Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: September 15, 2020
    Assignee: Varian Medical Systems International AG
    Inventor: Karl Otto
  • Patent number: 10765888
    Abstract: The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: September 8, 2020
    Assignees: Elekta AB, Elekta, Inc.
    Inventors: Jens Olof Sjolund, Xiao Han
  • Patent number: 10751546
    Abstract: Provided are a radiation treatment planning system and a radiation treatment system that are capable of achieving time shortening and labor saving of treatment planning making when a radiation treatment is planned. A predicted DVH calculation portion 4034 of an arithmetic processing device 403 in a radiation treatment planning system 400 anisotropically enlarges a target region 501 in an irradiated body image which is input to the radiation treatment planning system 400, and calculates an overlap volume OV with an organ-at-risk region 502 per the number of times of enlargement. A DVH (Dose Volume Histogram) is predicted from a volume of the calculated OV, and a dose histogram in the OV per the number of times of enlargement which is calculated from a past treatment planning data group, and is displayed on a display device 401.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: August 25, 2020
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Taisuke Takayanagi, Toru Umekawa, Shinichiro Fujitaka, Seishin Takao
  • Patent number: 10751550
    Abstract: A system for delivering radiation dose, includes a gantry to move about a target to be irradiated and a radiation source mounted to the gantry and directed inward toward the target, The system further includes a collimator mounted to the gantry and in front of the radiation source, the collimator to shape a radiation beam directed at the target, wherein the collimator is to modulate a sub-beam intensity of the radiation beam across a plurality of sub-beams that subdivide a fluence field into a two-dimensional (2D) grid, and wherein a plurality of independent two-dimensional (2D) sub-beam intensity patterns are delivered from a plurality of gantry angles while the gantry moves continuously.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: August 25, 2020
    Assignee: ACCURAY INCORPORATED
    Inventors: Eric Schnarr, Robert O'Connell, Richard Nash, Matthew Orton, Jacob Shea
  • Patent number: 10737114
    Abstract: A method and system are provided for converting clinical criteria constraints for a target structure of radiation therapy into a second set of constraints. The method includes selecting, by a hardware processor, a plurality of clusters of voxels in the target structure based on pre-specified criteria. The method further includes assigning, by the hardware processor, each of the plurality of clusters of voxels a respective constraint that specifies one or more bounds on a radiation dose applied to each voxel in a corresponding one of the plurality of clusters of voxels. The method also includes storing, in a memory device, the respective constraint for each of the plurality of clusters of voxels.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 11, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Anne E. Gattiker, Sani R. Nassif, Tom Osiecki, Chin Ngai Sze
  • Patent number: 10737116
    Abstract: When reducing radiation dose to healthy tissue near a target volume, a 4D motion model (52) of a target volume is generated during CT scan data acquisition. The target volume is tracked, and tracked target volume position information (43) is provided to a motion estimation tool (48). Motion parameter information (60) output from the motion estimation tool is linked to motion phases of the target volume indicated by CT scan data. A dynamic planned target volume (PTV) (64) that covers the target volume in each motion phase is generated and linked to tracked motion parameters for each respective motion phase. A radiation dose is delivered to the PTV for each motion phase using the linked motion parameters and real-time tracking information.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 11, 2020
    Assignees: KONINKLIJKE PHILIPS N.V., BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Shyam Bharat, Sankara Hari Gopalakrishnan, Amit Ramakant Sawant
  • Patent number: 10737118
    Abstract: A method of monitoring a patient includes: obtaining an input image having a plurality of regions of interest by a processing unit; and determining a plurality of positions for the respective plurality of regions of interest by the processing unit; wherein the act of determining the plurality of positions comprises: accessing a plurality of templates; comparing the plurality of templates with respective areas in the input image using a comparator in the processing unit; and determining the plurality of positions based at least in part on a result of the act of comparing.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: August 11, 2020
    Assignee: Varian Medical Systems, Inc.
    Inventor: Hassan Mostafavi
  • Patent number: 10734118
    Abstract: Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients, wherein the data comprises a three-dimensional representation of the planning target volume and one or more organs-at-risk. The data further comprises an amount of radiation delivered to the planning target volume and the one or more organs-at-risk. The system further includes one or more processors programmed to access, from the memory area, the data and to develop a model that predicts dose-volume relationships using the three-dimensional representations of the planning target volume and the one or more organs-at-risk. The model is being derived from correlations between dose-volume relationships and calculated minimum distance vectors between discrete volume elements of the one or more organs-at-risk and a boundary surface of the planning target volume.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: August 4, 2020
    Assignee: Washington University
    Inventors: Kevin L. Moore, Sasa Mutic, Ryan Scott Brame, Lindsey Appenzoller
  • Patent number: 10735427
    Abstract: An electronic device and a program management method therefor are provided. The electronic device includes a communication interface, a memory, at least one processor, and a secure circuitry. The secure circuitry is configured to provide a first public key stored in the secure circuitry to the at least one processor. The at least one processor is configured to transmit the first public key to an external device and receive an encrypted secure program encrypted based on the first public key and a second public key generated by the external device, from the external device. The at least one processor is further configured to transmit the second public key and the encrypted secure program to the secure circuitry. The secure circuitry is configured to decrypt the encrypted secure program based on the second public key and a first private key which is symmetrical to the first public key.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: August 4, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Eun Young Kwon, Yang Keun Kim, Jong Su Kim, Taeck Ki Lee, Dae Haeng Cho, Chol Seo Park, Da Som Lee
  • Patent number: 10722731
    Abstract: A system and method for adapting treatment plan are provided. The method may include: obtaining a planning image of a region of interest relating to a first treatment fraction of a first treatment plan; obtaining a first image of the region of interest relating to a first scan of the region of interest with a first dose level; comparing the planning image with the first image to generate a first comparison result; determining whether the first comparison result satisfies a first replanning condition; causing, in response to a determination that the first comparison result satisfies the first replanning condition, one or more scanners to perform a second scan with a second dose level to provide a second image; and generating a second treatment plan according to the second image, wherein the second dose level is higher than the first dose level.
    Type: Grant
    Filed: September 30, 2017
    Date of Patent: July 28, 2020
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventor: Jonathan S. Maltz
  • Patent number: 10722733
    Abstract: A positioning apparatus and a positioning method has a control element and function 40 includes a radiograph acquisition element 41 that acquires radiograph data detected by two radiography systems selected from a group consisting of a flat panel detector, a DRR (Digital Reconstructed Radiograph) generation element 42 that generates DRR in two different directions by virtually performing fluoroscopic projection relative to the 3-dimensional CT data obtained through the network 17, a positioning element 43 that positions a CT to the X-ray fluoroscopic radiograph obtained from two radiography systems, and a displacement distance calculation element 44 that calculates a displacement distance of the tabletop 31 based on the gap between radiographs for improved positioning.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: July 28, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Wataru Takahashi
  • Patent number: 10716496
    Abstract: A data processing method performed by a computer for determining breathing signal data which represents a breathing cycle of a patient, comprising the steps of: —acquiring image data representing a sequence of training thermal images of at least a part of the surface of the patient's body over time, the sequence covering at least one half breathing cycle and being captured by a thermographic camera; and —tracking at least one tracked point in the image data over the sequence of training thermal images to find a trajectory of the tracked point as the breathing signal data, wherein the tracked point is a point on the surface of the patient's body.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: July 21, 2020
    Assignee: BRAINLAB AG
    Inventors: Hagen Kaiser, Kajetan Berlinger
  • Patent number: 10716954
    Abstract: In one embodiment, a method includes receiving treatment information relating to a treatment plan for proton- or ion-beam therapy intended to irradiate a target tissue; receiving machine-limitation information relating to one or more limitations of one or more machines involved in the proton- or ion-beam therapy; determining a time-optimized beam current for a proton or ion beam based on the treatment information and the machine-limitation information, wherein the time-optimized beam current minimizes the time required to deliver a required quantity of monitor units to one of a plurality of spots, wherein each of the plurality of spots is a particular area of the target tissue; and delivering the time-optimized beam current to the particular area.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 21, 2020
    Assignee: Varian Medical System Particle Therapy GmbH
    Inventors: Holger Goebel, Isabel Huth
  • Patent number: 10709610
    Abstract: Systems and methods for performing laser cataract surgery, for using a biometric system to determine a material property of a structure of the eye, laser pulses in a laser shot pattern having different powers. A therapeutic laser, and laser delivery system having the capability to vary the power of the laser beam.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 14, 2020
    Assignee: Lensar, Inc.
    Inventors: Dustin Morley, Gary P. Gray, Richard Ty Olmstead
  • Patent number: 10709905
    Abstract: Applicant presents an improved manner of modeling and calculating the tongue-and-groove effect in multi-leaf collimators in treatment planning systems and processes. The method is based on subtracting an individualized profile area that is determined for each individual model of MLC. The method also includes how to easily obtain the shape of this non-constant profile based on the tests. The method provides better accuracy, particularly for plans using small MLC gaps.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: July 14, 2020
    Inventor: Victor Hernandez
  • Patent number: 10702708
    Abstract: A radiation-treatment plan to treat a treatment target in a given patient takes into account imaging-based dosing of that patient by, for example, automatically accounting for radiation dosing of the given patient that results from imaging to determine at least one physical position of the given patient when forming the radiation-treatment plan. These teachings are particularly beneficial when applied in application settings where the aforementioned imaging comprises obtaining images using megavoltage-sourced radiation. By one approach these teachings provide for automatically accounting for radiation dosing of the given patient that results from imaging by, at least in part, automatically adjusting therapeutic dosing of the given patient as a function of the radiation dosing of the given patient that results from such imaging.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: July 7, 2020
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG
    Inventors: Mika Miettinen, Stefan J. Thieme-Marti, Jeff Everett, Andres Graf, Joakim Pyyry, Juha Kauppinen
  • Patent number: 10695587
    Abstract: A particle therapy system has an irradiation system attached to a rotary drum of a gantry. A radiation treatment cage disposed in the rotary drum includes a movable floor including a horizontal floor portion. The movable floor includes a number of footboards connected bendably and X-ray transmission plates. The movable floor has a slide member at each end thereof, and the slide member is movably attached to a guide rail that is provided for each of opposite side surfaces of the irradiation system. X-ray sources are disposed outside the rotary drum apart from each other in a circumferential direction of the rotary drum and attached to the outer surface of the rotary drum. The irradiation system includes X-ray detection systems opposite to the X-ray sources.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: June 30, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Tsutomu Yamashita, Tatsuya Fujisawa, Takenori Nishimura