Abstract: A method for delivering radiation treatment may include defining a preliminary trajectory including a plurality of control points. Each control point may be associated with position parameters of a gantry and a couch. The method may also include generating a treatment plan based on the preliminary trajectory by optimizing an intensity and position parameters of a collimator and MLC leaves for each control point. The method may also include decomposing the treatment plan into a delivery trajectory including the plurality of control points. Each of the plurality of control points may be further associated with the optimized intensity, the optimized position parameters of the collimator and the MLC leaves, an output rate, and a motion parameter of each of the gantry, the couch, the collimator, and the MLC leaves. The method may further include instructing a radiation delivery device to deliver the treatment plan according to the delivery trajectory.

Abstract: A medical image-processing apparatus according to an embodiment includes processing circuitry configured to determine a position of a feature point of a device in a first X-ray image, and generate a superimposed image in which a 3D model expressing the device is superimposed on the first X-ray image or a second X-ray image that is acquired later than the first X-ray image. The processing circuitry is configured to superimpose the 3D model on the first X-ray image or the second X-ray image at a position based on the position of the feature point.

Abstract: A radiotherapy apparatus for the delivery of an energetic beam to a target tissue in a treatment zone, including: a rotatable gantry for rotating the end of a beam delivery system about a circle centered on an isocentre and normal to an axis of rotation Z1 of the gantry, the path between the end of the beam delivery system and the isocentre defining a central beam axis Z2 at every rotation angle of the gantry about the axis of rotation Z1; an imaging ring having a central bore and an imaging system for acquiring images of a patient in an imaging zone of the imaging system, wherein the imaging ring is located in the radiotherapy apparatus such that its imaging zone intersects the axis of rotation Z1 of the gantry, and wherein the imaging ring is mechanically coupled to the rotatable gantry through a mechanical structure.

Abstract: A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least 0.05 mm, and optionally administering schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.

Abstract: The present disclosure provides a radiation therapy device and system. The radiation therapy device includes a first treatment head and a second treatment head. A beam emitted from the second treatment head intersects with a beam emitted from the first treatment head at an intersection point. The first treatment head is an X-ray treatment head, and the second treatment head is an X-ray treatment head, a multi-source focusing treatment head, or an intensity-modulated treatment head. The radiation therapy device may increase a dose rate at the intersection point.

Abstract: A radiation therapy system comprising a therapeutic radiation system (e.g., an MV X-ray source, and/or a linac) and a co-planar imaging system (e.g., a kV X-ray system) on a fast rotating ring gantry frame. The therapeutic radiation system and the imaging system are separated by a gantry angle, and the gantry frame may rotate in a direction such that the imaging system leads the MV system. The radiation sources of both the therapeutic and imaging radiation systems are each collimated by a dynamic multi-leaf collimator (DMLC) disposed in the beam path of the MV X-ray source and the kV X-ray source, respectively. In one variation, the imaging system identifies patient tumor(s) positions in real-time. The DMLC for the imaging radiation source limits the kV X-ray beam spread to the tumor(s) and/or immediate tumor regions, and helps to reduce irradiation of healthy tissue (e.g., reduce the dose-area product).

Abstract: A system for adjusting radiation target sites dynamically according to the moving states of a target object and for creating a lookup table of the moving states includes a detection chip, a radiation generation device, and a lookup table. The detection chip can be fixed on the target object to detect the current moving state of the target object. The detection chip or the radiation generation device, both configured for wireless signal transmission to each other, can activate or deactivate the radiation emitters of the radiation generation device individually according to the current moving state of the target object and the contents of the lookup table. As the system uses wireless transmission, and the lookup table has recorded the working state of each radiation emitter in each moving state of the target object, radiotherapy can be performed without a large number of tubes or sensors.

Abstract: Systems and methods for quality control in image-guided radiotherapy are provided. In some aspects, a method includes acquiring treatment images from a patient using an imaging system, and performing a registration using the treatment images and simulation images acquired during a simulation process. The method also includes computing at least one similarity metric based on the registration performed, and determining a conformance of the at least one similarity metric to predetermined limits. The method further includes generating a report indicative of the conformance.

Abstract: Disclosed is a computer-implemented method of determining a treatment plan, encompassing acquiring patient image data, acquiring target data describing targets, acquiring position data describing control points which define one or more arcs, and determining target projection data which describes outlines of the target in a beam's-eye view. Margin data is acquired. For the outlines, margins are applied to determine auxiliary outlines. Beam shaping device data is determined describing configurations of the collimator leaves so that irradiation of the auxiliary outlines is enabled. Based on these configurations, the irradiation amount is simulated for voxels of the patient image data. Constraints to be fulfilled by the treatment plan may be set. Configurations of blockings, arc-weights and margins are proposed. Only different combinations of these parameters are proposed while additional possible parameters are neglected. An optimization algorithm is used to minimize an objective function.

Abstract: An improved x-ray cone-beam CT image reconstruction by end-to-end training of a multi-layered neural network is proposed, which employs cone-beam CT images of many patients as input training data, and precalculated scattering projection images of the same patients as output training data. After the training is completed, scattering projection images for a new patient are estimated by inputting a cone-beam CT image of the new patient into the trained multi-layered neural network. Subsequently, scatter-free projection images for the new patient are obtained by subtracting the estimated scattering projection images from measured projection images, beam angle by beam angle. A scatter-free cone-beam CT image is reconstructed from the scatter-free projection images.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: A patient irradiation treatment plan verification system, the system constituted of: a treatment irradiation source arranged to output a treatment irradiation beam; a first detector; and a patient support member arranged to support a patient, the patient support member positioned between the treatment irradiation source and the first detector, wherein the first detector is arranged to detect the output treatment irradiation beam after the output treatment irradiation beam has irradiated the supported patient and output information regarding the detected irradiation beam.

Abstract: Example methods for adaptive radiotherapy treatment planning using deep learning engines are provided. One example method may comprise obtaining treatment image data associated with a first imaging modality and planning image data associated with a second imaging modality. The treatment image data may be acquired during a treatment phase of a patient. Also, planning image data associated with a second imaging modality may be acquired prior to the treatment phase to generate a treatment plan for the patient. The method may also comprise: in response to determination that an update of the treatment plan is required, processing, using the deep learning engine, the treatment image data and the planning image data to generate output data for updating the treatment plan.

Abstract: The present invention relates to the field of radiation therapy and methods, software and systems for treatment planning. A target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit is obtained. A first isocenter location procedure is performed including inter alia evaluating potential isocenter locations along normal directions of the surface and respective isodistance surfaces in respective starting voxels in a direction inwards from the surface, and a second isocenter location procedure is performed including inter alia identifying a median axis of the target volume or center point of the target volume, placing isocenters at locations along the median axis, and placing isocenters in the target volume based on a distance to existing isocenters and to the target surface.

Abstract: A system and method for optimizing fractionation schemes in planning radiation therapy are provided, as well as a computer program and a computer program product for carrying out the method, and an arrangement for planning radiation therapy. For optimizing the fractionation schemes, the following steps are performed. Anatomical image data of a subject to be treated is received by a biological impact calculation module as well as a predetermined radiation therapy treatment plan comprising a dose distribution to be delivered to the subject. A first set of reference parameters of a fractionation scheme is received, and also a second set of parameters of a fractionation scheme is received. Based on this, the module calculates the biological impact of the radiation therapy treatment. The calculated biological impact results are provided simultaneously for the first and the second sets of received parameters.

Abstract: A method of performing a radiological biopsy and associated system includes scanning a living human subject with a CT scanner to locate coordinates of an area of potential pathology and then using the coordinates to direct synchrotron radiation to a location at, or proximate the coordinates to obtain a high-resolution image of the area of potential pathology. The CT scan is accomplished with a CT scanner such as a C-Arm, vertical or horizontal CT scanner. A synchrotron radiation source emits synchrotron radiation through the subject and is processed by a processing system. The method and system allow for concurrent or sequential scanning of the subject by the CT scanner and synchrotron radiation scanner. The resulting images provide histological resolution of areas of potential pathology.

Abstract: A radiotherapy equipment is provided. The radiotherapy equipment comprises at least two radiation apparatuses, the radiation apparatuses are configured to be capable of emitting radiation beams, the radiation beams emitted by at least two of the radiation apparatuses intersect at an intersection point, the radiation apparatuses are rotatable circumferentially about a rotation axis, and radiation positions of at least two of the radiation apparatuses are positioned at different cross-sections with respect to the rotation axis.

Abstract: A radiation therapy system comprises a magnetic resonance imaging (MRI) system combined with an irradiation system, which can include one or more linear accelerators (linacs) that can emit respective radiation beams suitable for radiation therapy. The MRI system includes a split magnet system, comprising first and second main magnets separated by gap. A gantry is positioned in the gap between the main MRI magnets and supports the linac(s) of the irradiation system. The gantry is rotatable independently of the MRI system and can angularly reposition the linac(s). Shielding can also be provided in the form of magnetic and/or RF shielding. Magnetic shielding can be provided for shielding the linac(s) from the magnetic field generated by the MRI magnets. RF shielding can be provided for shielding the MRI system from RF radiation from the linac.

Abstract: Through the present invention, three-dimensional coordinates of a tracking object moving in an irradiation object can be calculated from fluoroscopic X-ray images captured and acquired from various angles in a single fluoroscopic X-ray device mounted to a radiation therapy apparatus. The three-dimensional coordinates of the tracking object are calculated on a straight tracking object presence line connecting an X-ray generating device for fluoroscopy and the position in an X-ray plane detector of the tracking object on the fluoroscopic X-ray image acquired by the X-ray generating device for fluoroscopy and the X-ray plane detector, and using line segment information included in a movement region of the tracking object set in advance.

Abstract: New techniques are described herein for providing a user-friendly interface for adjusting dose distribution values during optimization of a radiation application plan. In an embodiment, a graphical user interface is provided that provides an image of a target area for a radiation application, and a graphical overlay of a dose distribution disposed over the target area that visually represents the optimized dose distribution according to the input dose parameters. In one or more embodiments, the dose distribution may be automatically calculated from input parameters supplied by a user through the graphical user interface prior to optimization. A user (such as a clinician, radiation oncologist, or radiation therapy operator, etc.) is able to modify the visualization of the dose distribution volume during optimization via a user input device in conjunction with the graphical user interface and have the modification adjusted in real-time.

Abstract: A remote diagnostic monitoring of operating states for physical components of a particle accelerator system includes obtaining, by a processor at a first physical location, one or more operating states corresponding to one or more physical components associated with a particle emitting system and a particle delivery system each located at a second physical location remote from the first physical location, associating the operating states with corresponding operating indicators, generating a component hierarchy corresponding to a physical arrangement of the physical components of the particle emitting system and including the corresponding operating indicators, identifying a faulted physical component among the physical components, identifying fault path components among the physical components, the fault path components corresponding to a portion of the physical arrangement associated with the faulted physical component, modifying the operating indicators of the fault path components to fault state indicators

Abstract: A computer-implemented method of performing a treatment fraction of radiation therapy comprises: determining a current position of a target volume of patient anatomy; based on the current position of the target volume, computing an accumulated dose for non-target tissue proximate the target volume; determining that the accumulated dose is less than a current value for a dose budget of the non-target tissue; and in response to the accumulated dose being less than the current value for the dose budget, applying a treatment beam to the target volume while the target volume is in the current position.

Abstract: A radiographing apparatus includes a selecting unit configured to select a target dose index for radiographing based on a radiographing imaging mode, a dose index acquiring unit configured to acquire a dose index from image data based on radiation transmitted through a subject, and a calculating unit configured to calculate a deviation index of the dose index with respect to the target dose index. Alternatively, the radiographing apparatus may include a display control unit configured to display, on a display unit, information regarding the imaging mode, the target dose index and the dose index.

Abstract: A treatment planning apparatus 501 or a clinical decision support apparatus 701 calculates a dose distribution, calculates the damage to a normal tissue for a plurality of number of times of radiation irradiation based on the calculated dose distribution, and displays at least one or more calculated damages to the normal tissues on display apparatuses 603 and 703 or outputs the same to an outside of the apparatuses 501 and 701. Accordingly, since effects can be calculated for a plurality of number of times of irradiation, the optimum number of time of irradiation can be presented, and an operator and a doctor can be presented with a suitable decision material of a radiation irradiation planning.

Abstract: A medical or dental system with at least one first transmitting and/or receiving unit and at least one second transmitting and/or receiving unit, wherein the at least two transmitting and/or receiving units are designed for the capacitive coupling of electric signals into and/or out of a human body, so that an electric path which extends through the human body of the user and/or of the person to be treated can be established for the transmission of electric signals between the at least one first transmitting and/or receiving unit and the at least one second transmitting and/or receiving unit, in order to transmit data between the at least two transmitting and/or receiving units.

Abstract: A polymeric radiation-source with customized geometries to maximize receipt of radiation into treatment areas that is formed from either radioisotopes molecularly bonded to a polymer or radioisotopes encased within a polymer.

Abstract: An apparatus for producing a fundus image includes: a processor and a memory; an illumination component including a light source and operatively coupled to the processor; a camera including a lens and operatively coupled to the processor, wherein the memory stores instructions that, when executed by the processor, cause the apparatus to capture fundus images and provide controls for re-imaging the fundus.

Abstract: These teachings serve to facilitate radiating a treatment target in a patient during a radiation treatment session with a radiation treatment platform having a moving source of radiation and using an optimized radiation treatment plan. These teachings in particular provide for configuring the radiation treatment platform in a half-fan trajectory arrangement. These teachings then provide for beginning the radiation treatment session with the source of radiation in a first location and an isocenter for the treatment target in a first position. Then, during the radiation treatment session, these teachings provide for moving the source of radiation from that first location in synchronization with moving the isocenter from the aforementioned first position.

Abstract: A plurality of methods of registering and matching biological tissue images from a dynamic 3D medical model generated using medical images taken of biological tissues of a particular patient with a live video feed of the biological tissues of the particular patient, and a computer system for implementing such methods.

Abstract: The invention relates to a system for assisting in evaluating a contour of an anatomic structure (22) with respect to a dose distribution corresponding to a treatment plan for a radiation therapy treatment of a patient. The system comprises an evaluation unit particularly configured to evaluate the dose distribution in varying distances from the contour of the anatomic structure (22) to determine at least one point where the evaluated dose distribution fulfills a predetermined condition, and to determine the distance between the at least one point and the contour and/or to visualize the at least one point to a user of the system.

Abstract: A radiotherapy delivery device is provided. The device includes a source of therapeutic radiation and a first detector positioned to receive radiation from the source of therapeutic radiation. The device also includes a source of imaging radiation and a second detector positioned to receive radiation from the source of imaging radiation. A collimator assembly is positioned relative to the second source of radiation to selectively control a shape of a radiation beam emitted by the second radiation source to selectively expose part or the whole of the second radiation detector. A reconstruction processor can be operatively coupled to the detector and configured to generate patient images based on radiation received by the second detector from the second source of radiation. The device is configured to move from one imaging geometry to another using all or part of the second detector.

Abstract: The present disclosure provides methods for user adaptive radiation therapy planning and a system for using the same. In some aspect, method for generating a radiation therapy plan is provided. The method includes receiving imaging information acquired from a patient and producing a preliminary radiation therapy plan, using a treatment planning system, based on the imaging information. The method also includes generating an indication for modifying the preliminary radiation therapy plan in accordance with a predetermined clinician profile, wherein the predetermined clinician profile is based on a trained learning machine. The method further includes producing, using the indication, an updated radiation therapy plan that is adapted to the predetermined clinician profile.

Abstract: The present disclosure generally relates to an applicator for radiotherapy and a method for determining a thickness of a scattering foil and modulator therein. According to one embodiment, an applicator for radiotherapy may comprise a housing having a hollow structure with an opening, a scattering foil disposed at an opening of the hollow structure and configured to receive a first radiation and convert a portion of the first radiation into a second radiation while scattering the first radiation, and a modulator disposed inside the hollow structure and configured to modulate an intensity of mixed radiation including the first radiation and the second radiation.

Abstract: A treatment planning system for performing treatment planning of a charged particle beam treatment includes a calculation unit that calculates a dose distribution and an irradiation time required for the irradiation in a case where an irradiation target body is irradiated with a charged particle beam, corresponding to a plurality of predetermined cut-off dose values, and an output unit that outputs each of the cut-off values, data based on the dose distribution corresponding to each of the cut-off dose values, and the irradiation time corresponding to each of the cut-off dose values, to a display unit. The calculation unit cuts off an irradiation location having a dose which is equal to or smaller than the cut-off dose value, from doses required in respective irradiation locations of the irradiation target body, and thereafter, sets a current value of the charged particle beam when the dose distribution is calculated.

Abstract: Methods for dose or treatment planning for a radiotherapy system including a radiotherapy unit are provided. A spatial dose delivered can be changed by adjusting beam shape settings, and the delivered radiation is determined using an optimization problem that steers the delivered radiation according to objectives reflecting criteria for regions of interest including at least one of: targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes determining an inner set of voxels and providing a first frame description for the inner set of voxels, where the first frame description reflects criteria for the inner set of voxels. Determining an outer set of voxels encompassing the target volume and the inner set of voxels and a frame description for the outer set of voxels is provided where each reflecting criteria for the outer set of voxels. The frame descriptions are then used in the optimization problem that steers the delivered radiation.

Abstract: The present invention relates to the use of an inhibitor of HER-3 for the treatment of a hyperproliferative disease in combination with radiation treatment.

Abstract: Systems and methods for real-time target validation during radiation treatment therapy based on real-time target displacement and radiation dosimetry measurements.

Abstract: A method of operating a radiation apparatus is described that selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The method generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The method generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The method performs targeting tracking based on the first tracking image and the second tracking image.

Abstract: A medical image diagnostic system according to an embodiment includes processing circuitry configured to acquire first information related to an exposure dose of a subject by a radioactive agent administered to the subject, and display reference information for determining imaging conditions of X-ray CT imaging to be performed with respect to the subject on a display, based on the first information and second information related to a reference dose.

Abstract: The present disclosure discloses a laser verification apparatus employed in a radiotherapeutic device which comprises a plurality of radioactive sources, a collimator comprising a plurality of collimating holes, and a couch. The radioactive sources are capable of aligning in respect to the collimating holes respectively.

Abstract: A respiratory gating phantom device includes a first airbag, a second airbag, a first catheter, a second catheter, a fixture, and an air pressure gating device. The first catheter and the second catheter are respectively installed in the first airbag and the second airbag. The fixture is provided with a phantom tumor and adjustably installed in the first catheter or the second catheter, thereby installing the phantom tumor in the first catheter or the second catheter. The air pressure gating device, connected to the first airbag and the second airbag, inflates and deflates the first airbag and the second airbag to simulate breathing. The first catheter and the second catheter respectively move along three-dimensional direction and two-dimensional direction in response to motions of the first airbag and the second airbag.

Abstract: A method and a system are for calculating an output from a tomographic scrollable image stack, including a large number of generated sectional images of a tissue to be examined. In this context, a tomographic scrollable image stack is received. An output for a display is calculated. The output includes a primary image that is intended for representing the received image stack, and the output includes a secondary image with additional information. The secondary image is displayed overlaid on the primary image once an unhide signal or hide signal is received. In this context, a reference may be provided between the additional information of the secondary image and the slice of tissue for examination that is shown in the sectional image of the image stack.

Abstract: A method of optimizing a radiotherapy treatment plan is disclosed, comprising the steps of: a. obtaining a deliverable input treatment plan; b. optimizing the deliverable input treatment plan to obtain an optimized treatment plan, using an objective function and at least one constraint, wherein i. the objective function is related to reducing the plan complexity in terms of minimizing the machine output (MU) and/or minimizing the time required to deliver the plan and/or maximizing the segment area, and/or minimizing jaggedness of the MLC shapes, ii. to ensure that the quality is maintained, the at least one constraint is based on the dose distribution of the input plan, related to maintaining an acceptable dose distribution.

Abstract: Generating a plan for radiation treatment of multiple target volumes such as, for example, multiple brain tumors, involves optimizing a grouping of the target volumes into subsets and generating treatment plans for each subset. Resulting treatment plans may minimize radiation dose to tissues outside of the target volumes. A radiation treatment planning system may be configured to operate in this manner and to upload control signals which cause a radiation therapy device such as a linear accelerator to execute the radiation treatment plans.

Abstract: A radiation dosimeter for measuring radiation dose within a region includes a structure having a scintillating material that emits light when exposed to radiation. Deformable radio-luminescent elements are located within the structure and configured to generate optical energy in response to irradiation.

Abstract: The present invention provides electron beam therapies with improved feedback control that delivers controlled and adjustable doses of electron beam radiation to variable shallow depths with little radiation exposure to both nearby tissues and tissues below the target. In order to control radiation to accurately penetrate to shallow depths and to allow the radiation to be adjusted to other depth settings in very small or even continuous increments, the present invention senses a plurality of different electron beam characteristics and then uses these to derive a composite characteristic, or analog, of the electron beam energy. The composite analog provides a strong correlation to energy that allows this precision. In another aspect, the present invention relates to implementing this feedback control by adjusting power levels used to establish the electron beam.

Abstract: Biometric health monitoring of a specific user or population is performed during biometric authentication for granting access to physical or digital assets. If biometric authentication, biometric verification and biometric health monitoring is acceptable, access to the physical or digital assets is allowed. Likewise, if a health anomaly is detected in a specific user or if an outbreak is detected in a specific community, an electronic notification can be sent to the individual, a health administrator, or to a government official, and access may be denied to the specific user.

Abstract: According to one embodiment, the radiotherapy system includes a medical image collecting device, a body surface data collecting device and processing circuitry. The medical image collecting device collects medical three-dimensional image data of the patient at the time of treatment planning. The body surface data collecting device collects body surface data representing a three-dimensional body surface of the patient at the time of treatment planning. The processing circuitry may generate integrated data in which at least one of the medical three-dimensional image data and the treatment target region data included in the medical three-dimensional image data, and the body surface data are integrated into an identical three-dimensional coordinate system.

Abstract: Systems and methods for powering a medical imaging machine and a workstation are provided. A vehicle houses the medical imaging machine and workstation. A combustion engine for the vehicle is connected to a generator and a drivetrain for moving said vehicle. One or more electrical panels receive electrical power from said generator and provide a first output at a first voltage to the medical imaging machine and a second output at a second voltage to the workstation controls of the medical imaging machine.

Abstract: Systems and methods are provided for radiation delivery. An exemplary method includes receiving an image depicting anatomical data of a target region of patient tissue and determining an initial prescribed dose of radiotherapeutic radiation to be delivered to the target region. The method also includes discretizing the arc for VMAT into a plurality of arc segments and performing an iteration process for determining an arc dose according to radiation delivered in the arc segments. The method further includes determining whether a condition for terminating the iteration process is met and terminating the iteration process based on a result of the determination that the condition for terminating the iteration process is met.