Automated System Patents (Class 422/509)
  • Patent number: 8383061
    Abstract: Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: February 26, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Manu Prakash, Neil Gershenfeld
  • Publication number: 20130045145
    Abstract: A structure for holding sample-containing receptacles includes a cover with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element adjacent each opening engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 21, 2013
    Applicant: GEN-PROBE INCORPORATED
    Inventor: Gen-Probe Incorporated
  • Patent number: 8377396
    Abstract: Gripping tool for automatic laboratory machines, with gripping appliances for gripping vessels, an appliance for converting and/or transferring of movements, the power take-off of which is coupled with the gripping appliances in order to drive them, a coupling appliance for detachable connection with a drive appliance of a tool support of an automatic laboratory machine, which is coupled with the drive of the appliance for converting and/or transferring in order to drive it, and a mounting appliance for detachable mounting of the gripping tool on the tool support of the automatic laboratory machine, while the coupling appliance is connected with the drive appliance of the tool support.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: February 19, 2013
    Assignee: Eppendorf AG
    Inventors: Matthias Meinicke, Jens Wilmer
  • Patent number: 8372356
    Abstract: A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: February 12, 2013
    Assignee: Integra Biosciences Corp.
    Inventors: Julian Warhurst, Gary Nelson, Richard Cote
  • Patent number: 8371181
    Abstract: A continuous flow syringe pump includes a first syringe configured for at least one of loading or dispensing at least one fluid, a second syringe configured for at least one of loading or dispensing the at least one fluid, and a first valve connected to the first syringe and the second syringe. The continuous flow syringe pump also includes a second valve connected to the first valve. The continuous flow syringe pump further includes at least one outlet connected to the first valve. The at least one outlet is configured to alternate output of the at least one fluid between the first syringe and the second syringe in a substantially continuous operation.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: February 12, 2013
    Assignee: Elemental Scientific, Inc.
    Inventor: Daniel R. Wiederin
  • Patent number: 8366997
    Abstract: A modular laboratory automation system for monitoring and controlling laboratory experiments, the modular laboratory automation system including a controller, an interface board, and a portable power supply. Power levels of standard laboratory equipment can be automatically controlled, and conditions and parameters of experiments can be automatically monitored and recorded. The laboratory automation system is modular and can be configured to operate with laboratory experiments having varying setups and equipment.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: February 5, 2013
    Assignee: Shoto Technologies LLC
    Inventor: Richard James Degroot
  • Patent number: 8367022
    Abstract: A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: February 5, 2013
    Assignee: Integra Biosciences Corp.
    Inventors: Julian Warhurst, Richard Cote
  • Patent number: 8361387
    Abstract: A method and system for automatically processing of liquid samples involving mixing of the samples with fluids are disclosed. The system includes a storing and handling device for storing and handling of fluid containers, which includes: a storing member provided with a plurality of storing positions, adapted for accommodating the fluid containers, the storing member having at least two storing levels, each of which extending in a plane, which are being stacked in a direction orthogonally aligned to the plane; and a handler, adapted for automatically transferring the fluid containers at least with respect to the storing positions. A method for operating such storing and handling device is also disclosed, wherein individual fluid containers are transferred between storing positions of a same or different storing levels in accordance with processing of the liquid samples.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: January 29, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gottlieb Schacher, Rolf Sigrist
  • Patent number: 8361396
    Abstract: Embodiments of the present invention are directed to automated-polymer-synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent-solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different output paths. The automated-polymer-synthesis systems that represent embodiments of the present invention generally include an input spur and output spur in addition to a main loop, allowing carriers containing only completed polymers to be removed and new carriers input, so that carriers traverse the automated-polymer-synthesis systems independently from one another.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: January 29, 2013
    Assignee: Oligoco, Inc.
    Inventors: Hsing-Yeh Parker, John C. Tabone, John Mulligan
  • Patent number: 8364315
    Abstract: The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: January 29, 2013
    Assignee: Advanced Liquid Logic Inc.
    Inventors: Ryan A. Sturmer, Gregory F. Smith, Michael Fogleman, Keith R. Brafford, Sai Ram Rongali
  • Patent number: 8361415
    Abstract: An inertial particle focusing system for use with a particle having diameter (a) includes a curved microchannel into a substrate, said microchannel having a radius of curvature (r), and a channel hydraulic diameter (Dh), wherein the ratio of r to Dh satisfies the following criterion: 2ra2/Dh3?0.037.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: January 29, 2013
    Assignee: The Regents of the University of California
    Inventors: Dino Di Carlo, Daniel R. Gossett
  • Publication number: 20130017128
    Abstract: Embodiments include integrated robotic sample transfer devices and components thereof which are used for reliably and accurately transferring small samples of material from one registered position to another registered position. Such transfers of material may be carried out by a single pin tool or an array of pin tools of a pin tool head assembly of robotic sample transfer devices. Some embodiments also include automated cleaning of the pin tools used to transfer the sample material. Some embodiments are fully integrated units having internal fluid supply and waste tanks, vacuum source, fluid pumps, controllers and user interface devices.
    Type: Application
    Filed: September 24, 2012
    Publication date: January 17, 2013
    Applicant: SEQUENOM, INC.
    Inventors: Rolf SILBERT, Richard Capella, Justin Cuzens
  • Publication number: 20130017127
    Abstract: A dispensing apparatus includes: a dish mounting portion having a mounting surface mounted with a dish having a bottom surface and a side surface surrounding the bottom surface; a syringe, arranged above the dish mounting portion, having a nozzle configured to discharge liquid toward an interior of the dish; and a first driving portion configured to change the syringe in direction with respect to a first axis as a center, wherein the first axis is orthogonal to a normal to the mounting surface of the dish mounting portion.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 17, 2013
    Applicant: PANASONIC HEALTHCARE CO., LTD.
    Inventor: Tomoyoshi TOKUMARU
  • Patent number: 8354078
    Abstract: The present invention is to present a liquid dispensing apparatus which is capable of preventing contamination by previously aspirated liquid, even when residual liquid in a pipette tip separated from the dispensing apparatus is scattered. The liquid dispensing apparatus includes: sample dispensing arm 5 which comprises a dispensing nozzle 54b for aspirating and discharging sample on which a pipette tip 200 is attached; tip separating section 140 for separating the pipette tip 200 from the dispensing nozzle 54b; and nozzle wiping section 16 for cleaning a tip of the dispensing nozzle 54b.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: January 15, 2013
    Assignee: Sysmex Corporation
    Inventors: Keiichiro Shohmi, Tomoyuki Nishida, Yoshinori Ooi
  • Patent number: 8354079
    Abstract: The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: January 15, 2013
    Assignee: CyBio AG
    Inventor: Uwe Naumann
  • Patent number: 8354064
    Abstract: Disclosed herein are an apparatus for producing liposomes and a method of producing liposomes by which it is made possible to produce liposomes under sterile conditions during the manufacturing process while monitoring in line the particle diameter of liposomes.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: January 15, 2013
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Koji Nakamura, Keisuke Yoshino, Yasuo Kurosaki
  • Publication number: 20130011880
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kristopher Barbee, Maximilian Carpino, Ray Alan Wheeling, Nicholas Peter Bajka
  • Patent number: 8343443
    Abstract: A micro-fluidic device comprises a body. The body defines pneumatic ports, chambers for receiving liquids, and a connecting conduit. Each port is sealed with a seal and is shaped to couple to a pneumatic conduit through the seal. At least some of the chambers each have a top opening and a bottom opening. The top openings are in fluid communication with corresponding ports. The bottom openings are in fluid communication with one another through the connecting conduit, which is above the bottom openings. Selective application of pneumatic pressures to the chambers through the pneumatic conduits can transfer a liquid from one chamber to another through the connecting conduit, for example, for processing bio-samples within the device.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: January 1, 2013
    Assignee: Agency for Science, Technology and Research
    Inventors: Jackie Y. Ying, Guolin Xu, Hock Ming Jeremy Loh
  • Patent number: 8343423
    Abstract: A diluted sample is reused to remeasure a sample whose measurement has been completed, which is to be manually performed. An automatic analyzer can set hold and discard conditions and manage the elapsed time after a diluted sample is pipetted. It is possible to check, before measurement is performed, whether or not each requested measurement item can be measured, and the length of time it takes before measurement of all samples is completed. The automatic analyzer has functions of: setting diluted sample hold and discard conditions; allowing an operator to specify a kind of sample, for example, to select between a parent sample and a diluted sample; separately executing pipetting or measurement; and displaying each requested measurement item for which a sample or a reagent is insufficient, and displaying the length of time it takes until measurement of all samples is completed.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: January 1, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroki Mori, Yasuo Kaneko, Toshihide Orihashi
  • Patent number: 8337779
    Abstract: A reagent open mechanism of the luminescence measurement system comprises a triaxial actuator and a reagent dispensing nozzle which is driven by the triaxial actuator. A reagent cartridge where a reagent to be divided by the reagent dispensing nozzle is filled in a concave and the opening of the concave is sealed by an aluminum sheet can be set in. This reagent open mechanism comprises an open needle which is driven by the triaxial actuator and makes a hole in the aluminum sheet and a fixation block between the reagent dispensing nozzle and the open needle which arranges the reagent dispensing nozzle and the open needle in such location that the reagent dispensing nozzle or the open needle does not contact with a structure including the reagent cartridge in a Z-axis operation during opening time or reagent dividing and dispensing time.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: December 25, 2012
    Assignee: Hitachi Plant Technologies, Ltd.
    Inventor: Noe Miyashita
  • Patent number: 8337781
    Abstract: The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can be filled into a liquid container (7, 11a-11d, 13, 15). A plurality of cassettes (5) can be held by a transport device (4). Using the transport apparatus (6), a transport device (4) can be brought to a liquid container (7, 11a-11d, 13, 15) and/or moved away from a liquid container (7, 11a-11d, 13, 15). A sequence of operations (8) can be prescribed in which a transport device (4) runs through the liquid containers (7, 11a-11d, 13, 15) of the tissue infiltration device (1).
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: December 25, 2012
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Hermann Ulbrich, Marc Konrad, Peter Richter
  • Patent number: 8333936
    Abstract: The present invention provides for a reagent splitting/dispensing device and method that can prevent contamination of an operation fluid when a reagent dispensing nozzle is in a waiting state and prevent falling of a droplet. The reagent splitting/dispensing method includes disposing and adjusting an air layer between an interface of an operation fluid and a reagent aspirated and subsequently dispensed from a nozzle tip end in an reagent dispensing nozzle.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: December 18, 2012
    Assignee: Hitachi Plant Technologies, Ltd.
    Inventors: Noe Miyashita, Hideyuki Noda, Masahiro Okanojo
  • Patent number: 8329114
    Abstract: Devices, instruments, systems and methods are provided in which a primary line that receives a biological fluid is selectively sampled by a plurality of collection chambers. Selective sampling occurs by selectively accessing the primary line and selective engagement of a sampling pump under control of a microprocessor. Further, the instrument housing reversibly houses a drive assembly and sample collection housing to permit the interchangeability of drive assemblies and collection housings and thus enhance sterility or reduction of cost.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: December 11, 2012
    Assignee: Hemobotics, LLC
    Inventor: John Temple
  • Patent number: 8322199
    Abstract: The present invention provides an automatic sampling and dilution apparatus for use in a polymer analysis system. The apparatus comprises (a) a primary mixing chamber; (b) a primary pump capable of continuously withdrawing a variable viscosity liquid from a reactor at a selectable, fixed withdrawal rate over a varying viscosity range of about 50 to about 5,000,000 centipoise (cP) for continuously conveying the variable viscosity polymer-containing liquid into the primary mixing chamber; (c) a first dilution pump for continuously delivering a first dilution solvent into the primary mixing chamber at a selectable, fixed flow rate to mix with the variable viscosity liquid in the mixing chamber and thereby form a diluted polymer-containing liquid therein; and (d) a secondary pump for continuously conveying the diluted polymer-containing liquid into a flow-through detector. A polymer analysis system utilizing the automatic sampling and dilution apparatus is also provided.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: December 4, 2012
    Assignee: The Administrators of the Tulane Educational Fund
    Inventor: Wayne F. Reed
  • Patent number: 8309357
    Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: November 13, 2012
    Assignee: Bayer HealthCare, LLC
    Inventor: Kevin Chang
  • Patent number: 8303895
    Abstract: An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: November 6, 2012
    Assignee: Capheid
    Inventors: Ronald Chang, Douglas B. Dority, Lee A. Christel, Robert Yuan, Kurt E. Petersen
  • Patent number: 8303894
    Abstract: The fluidic system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone to a waste container, in which the flow rate of the sheath fluid is different from the flow rate of the waste fluid thereby drawing a sample fluid from a sample container into the interrogation zone, a detection system that provides a data set of input signals from the sample fluid, an analysis engine that recognizes aggregate particle events in the data set, and a controller that automatically adjusts the flow rate of the sample fluid into the interrogation zone based on the recognition of aggregate particle events, by controlling at least one of the flow rates of the sheath fluid and the waste fluid.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: November 6, 2012
    Assignee: Accuri Cytometers, Inc.
    Inventor: Collin A. Rich
  • Patent number: 8303909
    Abstract: Embodiments of a microfluidic assembly comprise at least two adjacent microstructures and a plurality of interconnecting fluid conduits which connect an outlet port of one microstructure to an inlet port of an adjacent microstructure. Each microstructure comprises an inlet flow path and an outlet flow path not aligned along a common axis. Moreover, the microfluidic assembly defines a microfluidic assembly axis along which respective inlet ports of adjacent microstructures are oriented or alternatively along which respective outlet ports of adjacent microstructures are oriented, and each microstructure is oriented relative to the microfluidic assembly axis at a nonorthogonal angle.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: November 6, 2012
    Assignee: Corning Incorporated
    Inventor: Mark Stephen Friske
  • Patent number: 8303913
    Abstract: A tissue processor for treating tissue samples comprises a process chamber (10) in which the tissue samples can be treated with at least one liquid. The process chamber (10) is formed as a vessel of a magnetic stirrer. In the process chamber, a stirring body (16) for stirring the liquid is arranged, wherein the stirring body (16) comprises at least one magnet (40a, 40b) with the aid of which the stirring body (16) can be set in rotation by a drive unit (20) of the magnetic stirrer, and at least one vane (28a to 28f) by which the liquid to be stirred is stirred when the stirring body (16) rotates. According to a first aspect of the invention, the stirring body (16) has at least three vanes (28a to 28f), according to a second aspect of the invention, the stirring body (16) has at least one further magnet (40b). The north pole (46) of the one magnet (40a) and the south pole (50) of the further magnet (40b) face the drive unit (20).
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 6, 2012
    Assignee: Leica Instruments (Singapore) Pte. Ltd.
    Inventor: Claus Haberkorn
  • Patent number: 8298497
    Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: October 30, 2012
    Assignee: The Secretary of State for Defence
    Inventor: David James Squirrell
  • Patent number: 8293191
    Abstract: The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: October 23, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Yoshinobu Kohara, Masataka Shirai, Hideyuki Noda, Tomoyuki Sakai, Kenko Uchida
  • Patent number: 8287806
    Abstract: A pipetting apparatus has a fluidic space to which a pressure transducer with a pressure sensor is attached with a gas filled space. The fluidic space is defined by a pipette tip, a first tubing that connects the pipette tip to a pump, and an active part of the pump. The pipetting apparatus further has an impulse generating mechanism that is in operative contact with a column of system liquid inside the fluidic space. The impulse generating mechanism induces a vertical movement in the system liquid column, which results in a pressure variation in the gas filled space that is pneumatically connected with the fluidic space. This pressure variation, as recorded with the pressure transducer and as processed by a first data processing unit during utilization of this pipetting apparatus, is taken as an indicator for the detection of penetration or of quitting of a surface of a liquid, with an orifice of the pipette tip, of which liquid an amount is to be aspirated and dispensed.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: October 16, 2012
    Assignee: Tecan Trading AG
    Inventors: Torleif Ove Bjornson, Robert Liebhard, Adi Zuppiger, Dirk Heerklotz
  • Patent number: 8287820
    Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: October 16, 2012
    Assignee: HandyLab, Inc.
    Inventors: Jeff Williams, Kerry Wilson
  • Patent number: 8282895
    Abstract: A reagent cabinet for an automated processing apparatus. The reagent cabinet has a housing, and a drawer slidably mounted in the housing. The drawer has a lower deck adapted to receive a fluid reservoir, and an upper deck located above the lower deck and adapted to receive a fluid supply container. A supply connection hose is provided to selectively connect the fluid supply container to the fluid reservoir. A reservoir connection hose is provided to selectively connect to the fluid reservoir and to convey fluid from the fluid reservoir to a downstream location outside the cabinet. A pump is mounted on the drawer. The pump is adapted to convey fluid through either the supply connection hose or the reservoir connection hose.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: October 9, 2012
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Jonathan Matthew Miller, Yancy Kenan Ragin
  • Patent number: 8277758
    Abstract: In an assembly for actuating a syringe, two gripping devices are designed to receive and withhold a containment cylinder and, respectively, a piston of the syringe, and are defined by respective pairs of jaws for gripping a flange of the containment cylinder and, respectively, of an end head of the piston, the jaws of at least one gripping device being mobile with respect to one another between a gripping position and a release position under the thrust of a corresponding actuation device.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: October 2, 2012
    Assignee: AEA, S.r.l.
    Inventor: Graziano Mattioli
  • Patent number: 8268261
    Abstract: A pipette core member is used in a pipette for sampling a sample. This pipette core member includes: a pump body including a reservoir communicated with one suction/discharge port of an electroosmotic flow pump, the electroosmotic flow pump and the reservoir being integrally formed; and a capillary connected to the electroosmotic flow pump and communicated with the other suction/discharge port of the electroosmotic flow pump. The capillary is secured to the pump body.
    Type: Grant
    Filed: November 22, 2007
    Date of Patent: September 18, 2012
    Assignees: Altair Corporation, Nano Fusion Technologies, Inc., Kazusa DNA Research Institute
    Inventors: Mamoru Hirafuji, Ichiro Tominaga, Shigeto Eda, Ichiro Yanagisawa, Osamu Ohara
  • Patent number: 8263023
    Abstract: A microfluidic system and method for sorting cell clusters, and for the continuous and automated encapsulation of the clusters, once sorted, in capsules of sizes suitable for those of these sorted clusters is provided. The microfluidic system comprises a substrate in which a microchannel array comprising a cell sorting unit is etched and around which a protective cover is bonded, and the sorting unit comprises deflection means capable of separating, during the flow thereof, relatively noncohesive cell clusters, each of size ranging from 20 ?m to 500 ?m and of 20 to 10 000 cells approximately, such as islets of Langerhans, at least two sorting microchannels arranged in parallel at the outlet of said unit being respectively designed so as to transport as many categories of sorted clusters continuously to a unit for encapsulation of the latter, also formed in said array.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: September 11, 2012
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Sophie Le Vot, Jean Berthier, Florence Rivera
  • Patent number: 8256645
    Abstract: A fluid dispenser is disclosed where a backoff distance is determined and implemented to prevent leakage while dispensing sequentially an accurate, precise amount of fluid substantially independent of the fluid remaining in a syringe-type dispenser. The fluid characteristics of the fluid, e.g. viscosity, surface tension, etc. affect the backoff distance that may be determined heuristically for fluid type, amount of fluid remaining in the syringe and amount to be dispensed. Once the fluid characteristics are known, the dispensing may be accomplished automatically with a processor loading new drive and backoff steps to a motor controller.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: September 4, 2012
    Assignee: Fishman Corporation
    Inventor: W. Scott Beebe
  • Patent number: 8257664
    Abstract: A dispensing apparatus includes a probe that sucks or discharges a liquid; a pressure generating unit that generates a pressure necessary for the probe to suck or discharge the liquid; and a pressure measuring unit that measures the pressure generated by the pressure generating unit and applied to the probe. The apparatus also includes a setting unit that sets a correction coefficient used when correcting a physical amount based on characteristics of the dispensing apparatus using a result of the measuring by the pressure measuring unit; a storage unit that stores therein information including the correction coefficient set by the setting unit; and a correcting unit that corrects the physical amount using the correction coefficient stored in the storage unit.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: September 4, 2012
    Assignee: Beckman Coulter, Inc.
    Inventor: Hiroyuki Ogusu
  • Publication number: 20120220044
    Abstract: A biopsy pipette with a filter attached in an internal compartment of a pipette designed to prevent lodging and possible loss of the tissue specimen for analysis. A biopsy test tube may be provided with a biopsy bag attached in the internal compartment of the test tube. Further, a biopsy cassette may be provided with an opening configured to receive a pipette. An automated and non-automated system and method of using the biopsy pipette, biopsy test tube, and biopsy cassette in the processing of biopsy specimen is also disclosed.
    Type: Application
    Filed: February 27, 2011
    Publication date: August 30, 2012
    Inventors: Shree G. Sharma, Manisha Singh
  • Publication number: 20120214156
    Abstract: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
    Type: Application
    Filed: February 23, 2012
    Publication date: August 23, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Debjyoti BANERJEE, Konrad Faulstich, Aldrich N.K. Lau, Umberto Ulmanella, Jun Xie
  • Patent number: 8236256
    Abstract: A device for automatically aspirating and/or dispensing liquids with precision, comprising a housing having an opening at a lower end with a fixed tip protruding out of the lower end; an interchangeable cartridge disposed inside the housing, the cartridge having a holding frame and a spool of tubing provided in the frame such that one end of the tubing is aligned with the tip; and an actuator enabled to automatically extrude part of the tubing so as to accommodate a preselected volume of liquid, aspirate and/or dispense the liquid through the extruded tubing, and disconnect the extruded tubing from the device.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: August 7, 2012
    Inventor: Thomas Friedlander
  • Patent number: 8236257
    Abstract: This invention provides a biological component-measuring device, enabling the operator to easily calibrate the entire device and capable of measuring biological components accurately, and a method for calibrating the device. The device measures a sample including a body fluid taken through a body fluid sampler by sending it with a pump through a sample channel to a sensor. The device further includes a calibrating liquid channel through which a calibrating liquid can be supplied to the sensor via the sample channel by a switching of a first flow path changeover valve placed in the sample channel at a location upstream of the pump and connected to the channel. The method includes introducing the calibrating liquid in the calibrating liquid channel, via other channels, into the sensor by switching the valve.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: August 7, 2012
    Assignee: Nikkiso Co., Ltd.
    Inventor: Motoaki Murakami
  • Patent number: 8216525
    Abstract: A modular microfluidic system includes modules which are arranged next to each other in a row. Every module has a microfluidic part which rests on a contact surface of the module in a locally limited area and is forced against the contact surface by a fastening element. The microfluidic part includes a fluid channel system with fluid connections that are arranged on the top surface of the microfluidic part in edge areas relative to the adjoining microfluidic parts. The fluid connections of adjoining microfluidic parts are interlinked by respective connecting channels in a connecting part bridging the microfluidic parts, wherein the connecting part rests on the microfluidic parts in the edge areas. A clamping part rests against the lower surfaces of the adjoining microfluidic parts and is connected to the connecting part via an additional fastening element in the area between the microfluidic parts.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: July 10, 2012
    Assignee: Siemens Aktiengesellschaft
    Inventors: Astrid Lohf, Reinhold Schneeberger, Robert Sendner
  • Patent number: 8216517
    Abstract: A control system includes an estimator configured to determine a present state of a device and compare the present state of the device with an expected state of the device. The control system further includes a predictor operatively coupled to the estimator, and configured to predict an event for execution by the device to reach the expected state of the device. The control system also includes a supervisory control unit operatively coupled to the predictor and the device, and configured to facilitate execution of the predicted event by the device.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: July 10, 2012
    Assignee: General Electric Company
    Inventors: Vijaysai Prasad, Amol Rajaram Kolwalkar, Sunil Shirish Shah, Frederick Liberatore, Rajendra Naik
  • Patent number: 8216526
    Abstract: A microfluidic device is described, capable of generating multiple spatial chemical gradients simultaneously inside a microfluidic chamber. The chemical gradients are generated by diffusion, without convection, and can either be maintained constant over long time periods, or modified dynamically. A representative device is described with a circular chamber in which diffusion occurs, with three access ports for the delivery and removal of solutes. A gradient typically forms in minutes, and can be maintained constant indefinitely. Gradients overlapping with different spatial location, and a controlled rotation of a gradient formed by diffusion are demonstrated. The device can also be used to evaluate chemotactic responses of bacteria or other microorganisms in the absence of convective flow.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: July 10, 2012
    Assignee: The United States of America, as represented by the Secretary of Commerce, The National Institute of Standards and Technology
    Inventors: Laurie E. Locascio, Francisco Javier Atencia-Fernandez
  • Patent number: 8216827
    Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: July 10, 2012
    Assignees: Commissariat a l'Energie Atomique, Biomerieux SA
    Inventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
  • Patent number: 8211585
    Abstract: A seal structure is disclosed for forming a substantially fluid tight seal between a UEA and a plate of a fuel cell system, the seal structure including a sealing member formed in one fuel cell plate, a seal support adapted to span feed area channels in an adjacent fuel cell plate, and a seal adapted to cooperate with a UEA disposed between the fuel cell plates, the sealing member, and the seal support to form a substantially fluid tight seal between the UEA and the one fuel cell plate. The seal structure militates against a leakage of fluids from the fuel cell system, facilitates the maintenance of a velocity of a reactant flow in the fuel cell system, and a cost thereof is minimized.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: July 3, 2012
    Assignee: GM Global Technology Operations LLC
    Inventors: Jeffrey A. Rock, Gerald W. Fly, Steven G. Goebel, Jeff D. Williams
  • Patent number: 8211301
    Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: July 3, 2012
    Assignee: Abbott Laboratories
    Inventors: Scott G. Safar, Charles M. Galitz, Stephen L. Herchenbach, Chadwick M. Dunn, Larry L. McDowell
  • Publication number: 20120164026
    Abstract: A needle (300) for handling a fluid in an analysis system (10), the needle (300) comprising a needle body (302) made of a ceramic material and having a fluid conduit (304) extending between a fitting end (306) and a seat end (308), the fitting end (306) being connectable to a fitting (402) and the seat end (308) being insertable into a seat (602), wherein the needle body (302) is tapering, particularly conically tapering, towards the fitting end (306), a fixing body (310) arranged on the needle body (302) next to the fitting end (306) for exerting an axial force when the needle body (302) is connected to the fitting (402), and a slide-on element (312) to be slid over the needle body (302) so as to push the fixing body (310) towards the fitting end (306).
    Type: Application
    Filed: November 30, 2011
    Publication date: June 28, 2012
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Bernhard Dehmer, Joachim-Richard Wagner