Sample Mechanical Transport Means In Or For Automated Analytical System Patents (Class 422/63)
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Patent number: 9363991Abstract: A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software.Type: GrantFiled: March 21, 2014Date of Patent: June 14, 2016Assignees: President and Fellows of Harvard College, Northeastern UniversityInventors: Dale Larson, Jeffrey Ruberti, John Slusarz, Nicholas Goulas, Erin Rush, Trevor Ehret
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Patent number: 9354147Abstract: An apparatus including at least one of a stainer module and a coverslipper module; an imaging module; a storage module; an automated transport module for transporting at least one slide between at least one of the stainer module and the coverslipper module, the imaging module and the storage module; and a controller. A method including processing at least one slide; determining whether an imaging module is available for imaging of a biological specimen on the at least one slide; transporting the at least one slide to the imaging module using an automated transport module; and transporting the at least one slide to a storage module using the automated transport module when it is determined that the imaging module is not available. A system including a processing module for processing at least one slide including a biological specimen thereon. A machine readable medium.Type: GrantFiled: May 28, 2014Date of Patent: May 31, 2016Assignee: Sakura Finetek U.S.A., Inc.Inventor: Gilles Lefebvre
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Patent number: 9347966Abstract: In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water. Such being the case, the invention provides an automatic analyzer capable of sufficient stirring regardless of items to be analyzed. To sufficiently stir a substance to which a reagent has been added, the automatic analyzer is designed to alter stirring conditions after a given amount of time has passed since the addition of that reagent.Type: GrantFiled: May 1, 2009Date of Patent: May 24, 2016Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Chie Sugiyama, Shigeki Matsubara
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Patent number: 9316660Abstract: This reagent preparation apparatus prepares a reagent supplied to a measurement portion measuring a specimen with the reagent. The reagent is prepared from a first liquid and a second liquid different from the first liquid. The reagent preparation apparatus comprises a reagent preparation portion preparing the reagent and a control portion acquiring reagent information related to the reagent prepared by the reagent preparation portion, acquiring supply time information related to a time when the reagent prepared by the reagent preparation portion was supplied to the measurement portion and outputting the reagent information and the supply time information.Type: GrantFiled: August 26, 2011Date of Patent: April 19, 2016Assignee: SYSMEX CORPORATIONInventors: Tomoyuki Asahara, Kouichi Ookubo, Noriyuki Nakanishi
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Patent number: 9273306Abstract: Disclosed is an automatic nucleic acid purification apparatus which can prevent pollution due to aerosol generated from a biological sample containing high concentration target nucleic acid when the biological sample containing the high concentration target nucleic acid is mixed with other biological sample containing low concentration target nucleic acid or not containing the target nucleic acid. Further, disclosed is an automatic nucleic acid purification apparatus which can be applied to all kinds of nucleic acid purification equipments for purifying a plurality of biological samples using a magnet rode or a multi-pipette block moving in two or three axial directions, and which can minimize pollution due to the aerosol generated from the biological sample containing high concentration target nucleic acid and also can obtain accurate results.Type: GrantFiled: November 18, 2011Date of Patent: March 1, 2016Assignee: BIONEER CORPORATIONInventors: Han Oh Park, Byung Rae Jeong, Kwon Sic Kim
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Patent number: 9273344Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.Type: GrantFiled: October 28, 2014Date of Patent: March 1, 2016Assignee: LUMINEX CORPORATIONInventors: Steve Jia Chang Yu, Jesus Ching, Phillip You Fai Lee, David Hsiang Hu
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Patent number: 9274034Abstract: The invention relates to a processing apparatus (100) for processing tissue samples, having a control unit (140) configured to control at least one apparatus function of the processing apparatus (100); and a communication device (130, 135) configured to read at least one information item from a user identification unit (151, 152, 153) and convey the at least one information item to the control unit (140). The control unit (140) is configured to control the at least one apparatus function of the processing apparatus (100) based on the at least one information item conveyed.Type: GrantFiled: September 5, 2013Date of Patent: March 1, 2016Assignee: Leica Biosystems Nussloch GmbHInventor: Markus Berberich
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Patent number: 9255939Abstract: A sample analyzer comprises a pipette, a pipette moving mechanism and a position confirming member disposed at a position where the pipette can be moved by the pipette moving mechanism. The position confirming member comprises a space into which a tip end of the pipette can be inserted. When the sample analyzer carries out the position confirmation process, the tip end of the pipette is moved by the pipette moving mechanism so as to be inserted into the space of the position confirming member. When a sensor sensed that the tip end of the pipette collides with the position confirming member, the sample analyzer stops the movement of the pipette and notify that the pipette of the pipette moving mechanism has a problem.Type: GrantFiled: October 21, 2008Date of Patent: February 9, 2016Assignee: SYSMEX CORPORATIONInventors: Tomoyuki Nishida, Takatomo Kudo, Hiroto Toyoshima
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Patent number: 9250164Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: GrantFiled: February 5, 2014Date of Patent: February 2, 2016Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay Shivayogi Magavi
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Patent number: 9229017Abstract: A transport apparatus includes: a first transport line configured to transport a rack downstream along the transporting route; a second transport line configured to transport the rack upstream along the transporting route; and a controller including a processor and a memory that stores programs executable by the processor to: determine where to transport a post-tested rack according to whether or not retesting is necessary on any sample held in the post-tested rack; and according to a determination, instruct the transport apparatus to transport the post-tested rack selectively (i) along the first transport line either back to first sample processing unit, where the rack has been tested, or to a second sample processing unit located downstream of the first sample processing unit, or (ii) along the second transport line back from the first sample processing unit.Type: GrantFiled: December 23, 2010Date of Patent: January 5, 2016Assignee: SYSMEX CORPORATIONInventor: Nobuhiro Kitagawa
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Patent number: 9222927Abstract: Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates.Type: GrantFiled: August 2, 2011Date of Patent: December 29, 2015Assignee: Rohm and Haas CompanyInventors: Lyn Hughes, Donald Frederick Wright
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Patent number: 9207249Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.Type: GrantFiled: July 29, 2013Date of Patent: December 8, 2015Assignee: Caliper Life Sciences, Inc.Inventors: Michael Greenstein, Colin B Kennedy, James C Mikkelsen, Jr.
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Patent number: 9201085Abstract: A reagent loading mechanism includes a reagent loading unit and a reagent holding unit serving as a rotating mechanism. A reagent cover opening mechanism and a reagent transferring mechanism are disposed on the circumference of the reagent holding unit. A position at which the reagents can be continuously loaded from the reagent loading unit can be selected from accommodating positions in the reagent holding unit by setting the number (X) of held reagents and an offset number (Y) of the opening mechanism and the transferring mechanism to satisfy a relationship of X=nY+1 (n is arbitrary). In addition, the opening operation and the transferring operation are performed during the same period so that unnecessary operations of the mechanisms can be suppressed by controlling the sequence such that opening of the reagent covers and transferring of the reagents can be continuously performed.Type: GrantFiled: December 3, 2010Date of Patent: December 1, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventor: Masashi Akutsu
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Patent number: 9164113Abstract: A method adapted to transfer a sample container such as a capped sample tube is disclosed. In one aspect, the method includes gripping a sample tube body with a first gripper pair and a cap with a second gripper pair of a gripper apparatus. In another aspect, a seating member may contact the cap to aid in the positioning of the sample container. Apparatus and systems for carrying out the method are provided, as are other aspects.Type: GrantFiled: August 6, 2010Date of Patent: October 20, 2015Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Glenn M. Friedman, Erich Kling
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Patent number: 9134332Abstract: An automated instrument and process for processing samples is presented. The instrument comprises a sampling area for receiving samples and reaction vessels; an analytical area with a first device resource comprising at least one analyzer; a reaction area comprising a conveyor for reagent containers; an incubator; a second device resource comprising first functional devices, the first functional devices having access to the sampling area and the incubator such as to transfer reaction vessels from the sampling area to the incubator and/or to pipette samples and/or reagents into the reaction vessels; a third device resource comprising second functional devices, the second functional devices having access to the incubator and the analytical area such as to transfer the reaction vessels from the incubator to the analytical area and/or to dispense liquids or withdraw liquids from the reaction vessels.Type: GrantFiled: July 12, 2012Date of Patent: September 15, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Rolf Frey, Gottlieb Schacher
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Patent number: 9121795Abstract: The present invention provides devices, apparatuses and methods for automated processing of biological samples. This invention provides automated devices and automated methods of sequentially treating a biological sample with processing fluids in more than one washing basin. In some embodiments, the invention provides automated devices and automated methods of western blot processing. In some embodiments, the invention provides automated devices and automated methods of Southern blot processing. In some embodiments, the invention provides automated devices and automated methods of northern blot processing. In some embodiments, the invention provides automated devices and automated methods of staining biomolecules on solid supports. In some embodiments, the invention provides automated devices and automated methods of nucleic acid separation and isolation.Type: GrantFiled: October 29, 2010Date of Patent: September 1, 2015Inventors: Feng Tian, Daniel Liang Zou, Lingyun Ji
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Patent number: 9116090Abstract: The invention relates to a method for preparing tissue material. The method comprises placing a quantity of tissue material in a closable but liquid-permeable assembly of a mold and enclosing element, enclosing the tissue material, guiding the tissue material placed in the receiving space at least through a hydrophilic liquid such as an alcohol solution, wherein water is extracted from the tissue material; and embedding the tissue material placed in the receiving space by at least partially filling the receiving space with a matrix material; wherein the assembly of mold and enclosing element has an orientation relative to a reference direction, and the orientation in one treatment step differs from the orientation in another treatment step. The invention also relates to a device and mold for performing the method.Type: GrantFiled: October 6, 2011Date of Patent: August 25, 2015Assignee: Klinipath B.V.Inventors: Ronald Johannes Wilhelmus Kusters, Maricus Johannes Van Dijk
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Patent number: 9103809Abstract: An automated liquid handling system is disclosed. A system includes a first pipetting group, which includes at least one pipettor, movably arranged on a first arm; and a second pipetting group, which includes at least one pipettor, movably arranged on a second arm, wherein the first arm and the second arm are movably arranged on at least one track such that the first arm and the second arm can independently move along the at least one track while keeping the first arm parallel with the second arm, wherein the at least one pipettor of the first pipetting group is arranged on a side of the first arm facing the second pipetting group, wherein the at least one pipettor of the second pipetting group is arranged on a side of the second arm facing the first pipetting group.Type: GrantFiled: April 23, 2012Date of Patent: August 11, 2015Assignee: Agilent Technologies, Inc.Inventors: Daniel West, David Knorr, James E. Young, Kimberly Subrahmanyan, Nicholas Fleming, Randy K. Roushall
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Patent number: 9097627Abstract: A punching device is provided for processing samples applied to a sample card comprising at least one punching head with a punch and a lower die, the punch being movable between a resting position and a punching position. The punching head has a receiving opening into which a sample card can be introduced by a movable gripping unit, and a punching drive, which drives the movement of the punch between the resting position and the punching position. A piece of sample punched out from the sample card can be discharged at an outlet opening of the lower die into a receiving recess of a receiving container. The punching device has a receiving plate, which forms a cover of an outwardly sealed housing for a drive unit, by which a transport frame resting on the receiving plate is moved in a plate plane relative to the punching head.Type: GrantFiled: April 29, 2012Date of Patent: August 4, 2015Assignee: HAMILTON BONADUZ AGInventors: Nando Giovanoli, Reto Menzi
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Patent number: 9063038Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and ?l-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.Type: GrantFiled: March 13, 2013Date of Patent: June 23, 2015Assignee: Roche Diagnostics Operations, Inc.Inventors: Carlo Effenhauser, Patrick Griss, Stephan Korner, Emad Sarofim
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Publication number: 20150147820Abstract: A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir. The local reservoir for storing a bulk liquid for impending use can be a trough. The use of troughs for storing a reagent, a diluent, or some other treating agent for impending use enables an aspirating/dispensing device having a plurality of pipettes to aspirate and dispense the reagent,diluent, or other treating agent at a high rate of throughput. The controller can monitor the level of a liquid in (a) a local reservoir for storing a bulk liquid for imminent use and the level of liquid in a (b) container for holding a bulk liquid before the liquid is transferred to a local reservoir.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Inventors: Patrick P. Fritchie, Gregory E. Gardner, Richard W. Mahoney
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Publication number: 20150148549Abstract: The present disclosure sets forth incorporating microfluidic chips Interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.Type: ApplicationFiled: June 10, 2013Publication date: May 28, 2015Inventors: R. Michael Van Dam, Gaurav Shah, Pei-Yuin Keng
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Publication number: 20150147230Abstract: A configuration of detecting light from the front face of a light source is the best for confirming the variation of a light quantity, but when a plurality of light sources are present, as many detectors for checking a light quantity as the light sources are necessary and the apparatus configuration becomes complex. In the present invention, a detector for checking a light source light quantity is installed in a reaction container transfer mechanism used commonly for a plurality of detection sections, and the light quantities of light sources are checked with the detector.Type: ApplicationFiled: May 24, 2013Publication date: May 28, 2015Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Keiko Yoshikawa, Akihisa Makino
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Patent number: 9040303Abstract: An apparatus for measuring a volume of fluid includes at least one emitter configured to project a signal toward a predetermined position of a sample container, at least one receiver configured to receive the signal after the signal interacts with the sample container and a fluid transfer device in communication with the receiver and sample container. A change in the signal received by the receiver indicates when the fluid has dropped below the predetermined position. The apparatus determines a volume of fluid that the fluid transfer device has removed from the sample container when the receiver detects that the fluid has dropped below the predetermined position.Type: GrantFiled: March 18, 2013Date of Patent: May 26, 2015Assignee: Argos Therapeutics, Inc.Inventors: Simon Jonathon Spence, Richard Alexander Grant
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Publication number: 20150140669Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.Type: ApplicationFiled: November 3, 2014Publication date: May 21, 2015Inventors: Christoph Boehm, Peter Kupser, Norbert Oranth, Juergen Spinke, Thursten Brueckner, Timo Klein
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Patent number: 9034278Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.Type: GrantFiled: August 29, 2012Date of Patent: May 19, 2015Assignee: Battelle Memorial InstituteInventors: Andrew P. Bartko, Johnway Gao
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Patent number: 9034651Abstract: This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.Type: GrantFiled: June 22, 2010Date of Patent: May 19, 2015Assignee: Schlumberger Technology CorporationInventors: Li Jiang, Timothy Gareth John Jones, Andrew Meredith, Markus Pagels, Amilra Prasanna De Silva
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Patent number: 9028778Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.Type: GrantFiled: December 21, 2012Date of Patent: May 12, 2015Assignee: Abbott LaboratoriesInventors: Abe S. Mamaghani, Koshy T. Chacko, Rupa Rao, Rene Nieves
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Device for storing and handling Petri dishes, storage device and storage slot for laboratory objects
Patent number: 9028752Abstract: A device for storing and handling Petri dishes having a base with a base wall arranged on a circumference of the base, and a lid. The device includes a storage device structured and arranged for storing the Petri dishes in an upside-down orientation so that respective lids are oriented below their respective bases, an inspection device structured and arranged for automatic inspection of the Petri dishes without their respective lids, and a transfer device structured and arranged for transferring the Petri dishes between the storage device and the inspection device. The transfer device includes a gripper, with which a respective Petri dish without the lid can be grasped laterally on the base wall.Type: GrantFiled: January 27, 2012Date of Patent: May 12, 2015Assignee: Liconic AGInventor: Cosmas G. Malin -
Patent number: 9028756Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: GrantFiled: August 30, 2013Date of Patent: May 12, 2015Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
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Publication number: 20150125940Abstract: Disclosed is a container cleaning device which cleans a container for holding a sample. The device comprises: a container holding section for holding the container which has a substantially spherical inner bottom; a discharge section which is inserted into the container; and a cleaning nozzle which discharges a cleaning liquid into the container. The discharge section comprises an aperture at the bottom, and comprises a discharge flow path which is connected to the aperture and discharges the sample or the cleaning liquid in the container, and the discharge section is insertable to the deepest part of the container, and the bottom part of the discharge section conforms to the shape of the substantially spherical inner bottom of the container.Type: ApplicationFiled: October 29, 2014Publication date: May 7, 2015Inventors: Masahiko OGURO, Ryuichiro EBI
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Patent number: 9023278Abstract: A device (600) for performing at least part of an analytical process comprises a communicator (605) to facilitate communication with the device, and a data handler (610) to handle data of the analytical process and/or the device. In an embodiment, the device (600) is a consumable device and/or a microfluidic device. A method for performing at least part of an analytical process using a device comprises the steps of: (a) introducing a sample into the device; (b) handling data associated with the test using a data handler of the device; and (c) facilitating communications about the test using a communicator of the device. In another embodiment, the method is performed using a consumable device and/or a microfluidic device.Type: GrantFiled: January 11, 2007Date of Patent: May 5, 2015Inventor: Micah James Atkin
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Patent number: 9023279Abstract: A self-contained assay facility housed in a fixed-wing or rotary wing aircraft that is completely equipped to melt and assay precious metals, particularly gold and silver. An induction furnace melts the metal that is then poured into an ingot. The ingot is weighed and analyzed using an XRF alloy analyzer and the percentage of gold and/or other metals recorded. The value of the gold at current market prices is calculated and the assay and the value of the ingot is printed and given to the seller. The seller may opt to receive the ingot and pay the assayer an assay fee. Alternately, the seller may ask to be paid in cash, in bullion, by wire transfer, or by an open hedge. A transfer or hedge is initiated and confirmed from the assay facility. The ingots are securely stored in a safe within the assay facility.Type: GrantFiled: April 16, 2013Date of Patent: May 5, 2015Assignee: AOW Holdings, LLCInventor: Chris M. Noyes
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Patent number: 9016332Abstract: An apparatus for safety-compliant emptying and filling of a reagent container (24, 40) for a tissue processor (20) comprises a suction line (30, 42) for aspirating a reagent out of the reagent container (24, 40) and a delivery line (32, 44) for filling the reagent container (24, 40) with the reagent, a terminating opening (31, 43) of the suction line (30, 42) being spaced away from a terminating opening (33, 45) of the delivery line (32, 44).Type: GrantFiled: October 14, 2011Date of Patent: April 28, 2015Assignee: Leica Biosystems Nussloch GmbHInventors: Claus Haberkorn, Hermann Ulbrich
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Patent number: 9020782Abstract: A method and apparatus for controlling of ski vibration consisting an accelerator/actuator sub-system attached to the ski and a adaptive vibration control application residing in the user smart-phone and communicating with the accelerometer/actuator sub-system over Bluetooth radio interface is disclosed. The adaptive vibration control application extracts vibration frequencies and amplitudes from signal received from an accelerometer, separates such frequencies according to their types—bending or torsional, and after thresholding and scaling by the ski calibration parameters and by the user desired ski response, apply such signal to the control loop and consequently to the actuators to provide vibration dampening force. In one embodiment, such actuators are attached to the ski, while in another embodiment such actuators are embedded into the ski.Type: GrantFiled: October 28, 2013Date of Patent: April 28, 2015Assignee: IPCommInventors: Stanislaw Czaja, Grzegorz Staszczuk, Muhammad Afsar
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Publication number: 20150111202Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Inventors: Xuan S. Bui, Anthony L. Hartman, Toshiyuki Fujimaki, Shinji Tokudaiji, Yoshitake Okabe, Yoshitada Mizusawa
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Patent number: 9011770Abstract: The present invention provides a device for detecting the presence of an analyte in a liquid sample. The device has an opening for introducing the liquid sample into a first chamber for collecting the liquid sample, and a second chamber connected to the first chamber by a passageway and containing a test element. The device also has a third chamber connected to the second chamber by a channel and containing a movable member having first and second positions. The third chamber is divided by the movable member into first and second zones, and the first zone has a vent hole. The movable member is in contact with at least one wall of the third chamber to prevent gas communication between the first and second zones.Type: GrantFiled: October 26, 2005Date of Patent: April 21, 2015Assignee: Alere Switzerland GmbHInventors: Yuzhang Wu, Haipeng Hu, Jielin Dai, Lijian Gou
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Patent number: 9011771Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.Type: GrantFiled: May 17, 2010Date of Patent: April 21, 2015Assignee: Gen-Probe IncorporatedInventors: Norbert D. Hagen, Byron J. Knight, David Opalsky
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Patent number: 9011772Abstract: Provided herein is a bioprocessing device, bioprocessing card, and fluidics cartridge for performing automated bioprocessing of a sample. The bioprocessing card may include a plurality of pipette tips; and at least one pump in fluid communication with the plurality of pipette tips. In some embodiments, the pumps and the pipette tips are in fluid communication through a processing channel which may be a microscale channel. Also provided herein is an automated bioprocessing device comprising: at least one bioprocessing card; at least one fluidic cartridge; and an automated control system configured to control automated bioprocessing of a sample. Further provided herein are methods of use of the device, card, and cartridge.Type: GrantFiled: May 11, 2010Date of Patent: April 21, 2015Assignee: Life Technologies CorporationInventors: Lars Norderhaug, Morten Egeberg, Tommy Rivrud, Lars Nokleby, Espir Kahatt, Jamie Hogan, Kornelija Zgonc, Norman Trolson
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Patent number: 9011773Abstract: An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface.Type: GrantFiled: December 21, 2012Date of Patent: April 21, 2015Assignee: Abbott LaboratoriesInventors: John Scott Shoffner, Koshy T. Chacko, Roei Solomon
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Publication number: 20150104350Abstract: An apparatus, system for analyzing, and process for separating cuvettes supplied in bulk form are presented. The apparatus comprises a reservoir with an inlet for supplying cuvettes in bulk form to a reservoir space, a separator with an outlet for outputting separated cuvettes from a separator space communicating with the reservoir space, a reservoir spiral contained in the reservoir space to transport cuvettes to the separator space by rotating the reservoir spiral, and a separator spiral contained in the separator space to transport cuvettes to the outlet by rotating the separator spiral. Adjacent turns of the separator spiral have an inter-distance dimensioned such that a cuvette can be held in a holding position in which projections projecting outwards from a body for receiving liquid rest on adjacent turns, with the body dipping into a spiral groove between the adjacent turns.Type: ApplicationFiled: October 7, 2014Publication date: April 16, 2015Inventor: Gottlieb Schacher
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Patent number: 9005980Abstract: A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.Type: GrantFiled: October 18, 2013Date of Patent: April 14, 2015Assignee: Sakura Finetek U.S.A., Inc.Inventors: Robert E. Evans, Anthony L. Hartman, Richard A. Suchter, Gilles Lefebvre
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Patent number: 9005525Abstract: A transportable, self-contained assay facility built in a modified standard shipping container that is completely equipped to melt and assay precious metals, particularly gold and silver. An induction furnace melts the metal that is then poured into an ingot. The ingot is weighed and analyzed using an XRF alloy analyzer and the percentage of gold and/or other metals recorded. The value of the gold at current market prices is calculated and the assay and the value of the ingot is printed and given to the seller. The seller may opt to receive the ingot and pay the assayer an assay fee. Alternately, the seller may ask to be paid in cash, by bullion, wire transfer, or by an open hedge. A transfer or hedge is initiated and confirmed from the assay facility. The ingots may be securely stored in a safe within the assay facility.Type: GrantFiled: December 31, 2012Date of Patent: April 14, 2015Assignee: AOW Holdings, LLCInventors: Chris M. Noyes, Walter Nadonza
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Patent number: 8999240Abstract: An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.Type: GrantFiled: July 11, 2012Date of Patent: April 7, 2015Assignee: Hitachi High-Technologies CorporationInventors: Noriko Maeda, Kyoko Imai, Taku Sakazume, Yukie Tokiwa, Kantaro Suzuki
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Patent number: 8999264Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.Type: GrantFiled: September 26, 2011Date of Patent: April 7, 2015Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Michael J. Pugia
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Patent number: 8999241Abstract: A specimen analyzer comprising: a reagent refrigerator configured to store and cool a reagent container; a measurement unit configured to measure a specimen by using a reagent in the reagent container cooled by the reagent refrigerator; wherein the reagent refrigerator comprises: a housing configured so that an upper portion of the housing is openable and closable; a reagent container table configured so that the reagent container is set thereon, wherein the reagent container table is arranged within the housing so as to space away from a bottom of the housing; a first member arranged so as to face a side surface of the reagent container set on the reagent container table; and a second member arranged lower than the reagent container table, wherein the second member has a higher thermal conductivity than that of the first member.Type: GrantFiled: March 12, 2012Date of Patent: April 7, 2015Assignee: Sysmex CorporationInventors: Hironori Katsumi, Tsuyoshi Fukuzaki
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Patent number: 8999270Abstract: An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.Type: GrantFiled: May 23, 2014Date of Patent: April 7, 2015Assignee: BioPath Automation, L.L.C.Inventors: Warren P. Williamson, IV, Stephen P. Whitlatch
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Patent number: 8999269Abstract: The present invention relates to a glass plate (2) for use in a device (1) for stretching sample sections having a sectioning knife, the glass plate (2) being arranged at the back (3) of the sectioning knife in such a way that a defined gap (4) for reception of the sectioned sample is formed between the back (3) of the sectioning knife and the plate (2), the glass plate (2) possessing, at least on one of its longitudinal sides (21, 22), edges (211, 212; 221, 222) ground and polished to optical flatness.Type: GrantFiled: April 18, 2013Date of Patent: April 7, 2015Assignee: Leica Microsystems CMS GmbHInventors: Ralf Unger, Frank Eisenkrämer
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Publication number: 20150093834Abstract: A method is described for supplying consumables to an automated analyzer by providing at least one reagent and at least one solid consumable from a supply module which is docked to the analyzer, followed by undocking the supply module from the analyzer and removing it therefrom. Also described is a respective system and a supply module for supplying consumables to an automated analyzer.Type: ApplicationFiled: December 9, 2014Publication date: April 2, 2015Inventors: Urs Knecht, Siegfried Mueller, Markus Rinderknecht
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Patent number: 8992866Abstract: An automated, refrigerated specimen management system (ARSIMS) to hold sealed and/or opened sample/specimen tubes and/or containers that can be in the pre-analytical, in-process, or post-analytical phase of processing. The ARSIMS ensures that each sample/specimen tube, whether it is sealed, capped, closed or open, can be stored at an ideal storage temperature according to the particular phase of processing and as appropriate for the combination of sample/specimen type and analyte(s) to be tested.Type: GrantFiled: November 23, 2010Date of Patent: March 31, 2015Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Alexander Gelbman, Mark Edwards, Matthew Rosmarin, Ilya Malyarov, Benjamin Pollack, Elizabeth Bononno