Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include a first sensor member coupled to a base, wherein the first sensor member includes a semiconductor material, a second sensor member coupled to the base; and an active region in contact with at least the first sensor member. In some aspects, the first sensor member may be a fiber, and may have a conductive core and a semiconducting cladding surrounding the core. Manufacturing methods and apparatus utilizing the sensors are provided, as are numerous other aspects.

Abstract: A combinatorial chemical formation and assay disc (1) having a base (20) and an upper surface (26) and a lower surface, one of the upper or lower surfaces being an assay surface and a data surface (40) spaced from the assay surface wherein the data surface is on or within the assay disc. The assay surface has a conductive layer (64) on the base, a dielectric or photo-conductive layer (66) on the conductive layer and a chemically functional layer (68, 69) on the dielectric or photo-conductive layer. The assay surface may be planar or include three dimensional features (100, 168).

Abstract: Nanoparticles which are uniform with respect to the distance between particles, their interval and arrangement, which are capable of being fixed on the solid substrate having a large surface greater than about 10×10 cm2 using the Langmuir-Blodgett method. The nanofilm thus produced can be used as the substrate of an analytical sensor, and when the analytical sensitivity property is measured using the substrate of the analytical sensor thus prepared, it is seen that that the sensitivity or the sensor can be improved.

Abstract: A counterfeit currency detector including a tubular body having a forward end and a rearward end, a contact assembly mounted at the forward end of the tubular body, and a counterfeit solution applicator mounted at the rearward end of the tubular body. The contact assembly includes an ultraviolet light source.

Abstract: A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample.

Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.

Abstract: A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.

Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

Abstract: An optical material is inlaid into a supporting substrate, with the top surface of the optical material flush with the top surface of the substrate, wherein the optical element is used to shape a beam of light travelling substantially parallel to the top surface of the substrate, but with the central axis of the beam below the top surface of the substrate. The optical elements serve to shape the beam of light for delivery to or from a microfabricated structure within the device.

Abstract: A quencher for a flow cell battery is described. The quencher utilizes a quench solution formed from FeCl2 in a dilute HCl solution in order to quench chlorine emissions from the flow cell battery. A quench sensor is further described. The quench sensor monitors the concentration level of FeCl2 in the quench solution and may also monitor the level of the quench solution in the quencher.

Abstract: A flexible IC/microfluidic hybrid integration and packaging method and resulting device. A single flexible elastomer substrate, such as polydimethylsiloxane (PDMS), has dedicated microchannels filled with liquid metals (or low melting point solders) to provide electrical interconnects to a solid-state IC die, such as CMOS, and additional microchannels for hybrid integration with microfluidics without performing any post-processing on the IC die. The liquid metal used can be a gallium-indium-tin eutectic alloy (also called Galinstan).

Abstract: An analytical device for automated determining of a measured variable of a liquid sample, includes: a base module; a replaceable cassette connectable with the base module and having at least one liquid container connectable via a fluid line with a measuring cell and containing a reagent to be added to the liquid sample for forming a measured liquid; and a measuring transducer for registering measured values correlated with the measured variable for the measured liquid accommodated in the measuring cell. The cassette has, associated with the at least one liquid container, a fluid coupling apparatus having a primary component and a secondary component and serving for producing a connection of the fluid line with the liquid container.

Abstract: The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210, Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution, 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.

Abstract: An automatic analyzing apparatus which can make an adjustment to a target temperature so as to stabilize the light intensity of an LED and also can make the adjustment to that temperature in a short time is provided. The automatic analyzing apparatus in which an LED is used for a light source 114 includes a temperature adjusting mechanism 201 for the LED, and the temperature adjusting mechanism 201 includes a metal member 202 provided with the light source 114, a pair of metal pipes (water-flowing pipes) 203 buried in the metal member 202 and allowing constant-temperature bath water to flow therein, and pins (small metal piece members) 204 bringing only a heat-generating lead 252 of the light source 114 into direct contact with the metal member 202. Therefore, the temperature adjusting mechanism 201 can make an adjustment to a target temperature so as to stabilize the light intensity of the LED, and the adjustment to that temperature can be made in a short time.

Abstract: A method may include accessing data regarding a number of events, where the events were detected by a particle detection apparatus, and identifying a number of groups in the events. Each of the groups includes two or more events, and each event includes one or more of a time stamp, a time duration, a fluorescence intensity, a scatter measurement, a radio frequency signal, a magnetic signal, a neutron scattering measurement, a light scattering measurement, an electron scattering measurement, an audio signal, an acoustic signal, a mechanical signal, an electrical resistance, a thermal property, and a width of fluorescence signal. The method may include identifying a subset of the groups as a number of objects detected by the particle detection apparatus, where each object is identified based at least in part upon one or more quantities, where each quantity is identified by or derived from the respective two or more events.

Abstract: Light enhancement devices, applications for the light enhancement devices, and methods for making the light enhancement devices are provided. The light enhancement devices include a substrate and a film of metal disposed over the substrate, the film of metal including at least one cavity. The cavity may be of various shapes depending on the desired application.

Abstract: A system and apparatus for sorting a mixture of stained particles in a fluid flow path, including stained particles. The system can include a pulsed electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the stained particles, a processor for classifying the stained particles; and a photo-damaging laser for damaging selected particles in the flow path.

Abstract: A test element analysis system for the analytical investigation of a liquid sample. The test element comprising a carrier film having a first light guide layer having a flat side, a second light guide layer positioned adjacent to the first light guide layer and opposite of the flat side, and a coupling out zone which is part of the flat side of the first light guide layer. A test field is secured to the flat side and is constructed and arranged to receive a liquid sample. The test field comprises a reagent system having a soluble reagent capable of causing an optically measurable change upon reaction with an analyte of the liquid sample, and a detection zone in optical contact with the coupling out zone.

Abstract: The present invention is to present a sample analyzer which is capable of prevent consumable part which does not adapt to the sample analyzer from being used and maintain measurement precision. The sample analyzer 10 includes barcode reader 60 for obtaining serial number for identifying pipette tip 80 from barcode 83; containing section 21a for containing pipette tips 80 used by a predetermined mechanism section; CPU 34a for obtaining a number of the pipette tips 80 which have been used by the mechanism section; CPU 51a for obtaining a number of the usable pipette tips 80; warning screens 76, 77, 79 for giving a predetermined warning to a user, when the number obtained by CPU 34a is in a predetermined relationship with the number obtained by CPU 51a.

Abstract: Among others, the present invention provides micro-devices for detecting or treating a disease, each comprising a first sorting unit capable of detecting a property of the biological subject at the microscopic level and sorting the biological subject by the detected property; a first detection unit capable of detecting the same or different property of the sorted biological subject at the microscopic level; and a first layer of material having an exterior surface and an interior surface, wherein the interior surface defines a first channel in which the biological subject flows from the first sorting unit to the first detection unit.

Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.

Abstract: A method for measuring iron concentration that includes providing a sensor including a substrate, a ferrozine containing reagent, and a polymer covalently bonding the ferrozine containing reagent on the substrate. The sensor is inserted into an iron (Fe) containing sample. The ferrozine containing reagant reacts with iron (Fe) ions in the iron (Fe) containing sample. The optical properties of the sensor are measured after the ferrozine containing reagent reacts with the iron (Fe) ions in the iron (Fe) containing sample to determine the concentration of the iron (Fe) ions in the iron (Fe) containing sample.

Abstract: The invention concerns a diagnostic tape unit with a test tape that can be wound onto a spool which comprises a transport tape and a plurality of test elements mounted thereon, where the test elements have an analytical reagent layer, a carrier foil supporting the reagent layer and a piece of adhesive tape connecting the carrier foil with the transport tape, and where the front side of the reagent layer facing away from the carrier foil is designed for the application of a sample substance. According to the invention it is proposed that the test elements in combination with the light transmitting transport tape in each case form an optical multi-layer system for a rear-side reflection-photometric measurement of the reagent layer.

Abstract: Systems and methods for testing an engine lubricant are provided. The system includes a heated block having at least one cavity therein, at least one test cylinder receiving the engine lubricant therein, and at least one heated test piston selectively disposable into the engine lubricant of the test cylinder whereby deposits are formable on the test piston. The test cylinder is positionable in the cavity of the heated block and heatable thereby. Taxi oils and/or gases may be added to facilitate testing.

Abstract: The present invention provides a blood analyzer and a blood analyzing method capable of obtaining information regarding B lymphocytes and T lymphocytes without using a fluorescence-labeled antibody. The blood analyzer of the present invention includes a blood specimen supplying portion, a sample preparation portion that prepares a measurement sample without using a fluorescence-labeled antibody by mixing a blood specimen supplied from the blood specimen supplying portion, a hemolyzing agent, and a fluorescent dye that stains nucleic acid, a light source, a first detector that detects fluorescence, a second detector that detects scattered light, and information processing portion that classifies lymphocytes based on the intensity of fluorescence and scattered light, and based on the fluorescence intensity of the classified lymphocytes, obtains information regarding B-lymphocytes and T-lymphocytes.

Abstract: The present invention is directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel defining a chamber and a light source. The chamber has a chamber volume, a first window, an inlet and an outlet. The inlet is placed in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber receives a solution of one or more photo-reactive compounds over time to define a dwell time. The device further includes a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber.

Abstract: A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.

Abstract: A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.

Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.

Abstract: Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition.

Abstract: The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods.

Abstract: The present invention relates generally to the field of analysis, for example biological analysis.

Abstract: The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors—together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches.

Abstract: The present invention generally relates to the field of analysis, for example biological analysis. More specifically, the present invention relates to an article, especially for biological analysis, the article including: a first sheet, a second sheet, superimposed on the first sheet, the first and second sheets being joined on all of their sides in order to form a sealed package, at least one analysis device, placed inside the package, a rigid desiccation device, also constituting a device perforating the first or second sheet of the package, in order to access the analysis device, and one of the first and second sheets contains a notch which constitutes a preferential folding area.

Abstract: A test element for determining a body fluid is provided. The test element, in particular for determining the blood glucose level, includes a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in or adjacent to the detection region for detecting at least one status parameter for the detection region, such that the functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed.

Abstract: An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity.

Abstract: There is disclosed a method for controlling a photometric measuring unit of a measuring device for a bodily fluid sample, wherein a test field partially wetted by a bodily fluid sample is illuminated and light from a measuring area that covers a portion of the test field of the measuring unit is fed to a detector of the measuring unit, and the measuring area is displaced relative to the test field toward a partial surface wetted by the fluid sample and past the partial surface. The intensity of a detector signal is detected during the displacement, an extreme value in the course of the detector signal is determined, the measuring area is brought back to the position in which an extreme detector signal was previously measured, and the position of the measuring area in which the detector signal is extreme is used for a photometric determination of concentration.

Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.

Abstract: The present application provides a channel substrate having a channel provided therein and includes a plurality of detection portions configured to detect a specimen in the channel using an optical device, an introducing portion configured to introduce the specimen into the channel, and a discharging portion configured to discharge the specimen from the channel. The detection portions have, on at least one of the opposite faces of the channel substrate, detection portion surfaces which have distances different from each other to the channel.

Abstract: Techniques, apparatus, material and systems are described for implementing a three-dimensional composite mushroom-like metallodielectric nanostructure. In one aspect, a surface plasmon based sensing device includes a substrate and a layer of an anti-reflective coating over the substrate. The surface Plasmon based sensing device includes a dielectric material on the anti-reflective coating shaped to form a 2-dimensional array of nanoholes spaced from one another. Also, the surface Plasmon based sensing device includes a layer of a metallic film formed on the 2-dimensional array of nanoholes to include openings over the nanoholes, respectively, wherein the sensing device is structured to support both propagating surface plasmon polariton (SPP) waves and localized surface plasmon resonant (LSPR) modes.

Abstract: A method of removing abnormal data in a blood component analysis system using spectroscopy to estimate a concentration of a blood component by analyzing a photo-plethysmographic (PPG) signal obtained by radiating light of first and second wavelengths reacting to the blood component on a subject and detecting light corresponding to the first and second wavelengths output from the subject, includes collecting the PPG signal corresponding to the first and second wavelengths for a predetermined unit period of time, calculating “n” parameters, with respect to “n” pulse data included in the collected PPG signal, where n is a positive integer, calculating an average of the “n” parameters, and comparing a ratio of a number of parameters whose deviation from the average is greater than a predetermined standard deviation to the “n” parameters with a predetermined removal reference value to determine whether the “n” pulse data is valid.

Abstract: When assessing the start time of the limulus reaction between biogenous biologically active substances and LAL and using the reaction start time to determine the concentration of the biogenous biologically active substances, in order to exclude the influence of progressive changes which occur regardless of the conditions of the limulus reaction, the strength of transmitted light or scattered light in the liquid mixture of the measurement sample and LAL is detected, the variation (delta) in the transmittance or number of gel particles is acquired at set intervals, and the time when the variation (delta) crosses a threshold value is taken as the reaction start time. Furthermore, the time intervals when acquiring the abovementioned delta are not uniform, and either change over time from the start of measurement as defined by a time function, or multiple sequences with differing time intervals are prepared in advance.

Abstract: The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.

Abstract: A system and method for a flow cytometer system including a prepared sample fluid with reference beads; an interrogation zone that analyzes the prepared sample fluid; a peristaltic pump system that draws the sample fluid through the interrogation zone; and a processor that monitors a measured volume of sample fluid sampled by the peristaltic pump system and an expected sample volume based on data generated by the analysis of the sample fluid. A system and method is additionally described using an alternative volume sensing fluidic system.

Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size<2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.

Abstract: Large-scale downstream processing of secreted recombinant proteins is provided in a single device, wherein the contents of a plurality of bioreactors are combined simultaneous to their harvesting and purification resulting in significant savings of time and the cost of manufacturing.

Abstract: A portable handheld medical diagnostic device includes a housing forming a protective enclosure. A main circuit board is located in the protective enclosure. The main circuit board includes a controller facilitating a physiologic measurement. A display device is connected to the main circuit board that displays information related to the physiologic measurement. An electronic skin is on the housing. The electronic skin comprises a liquid crystal material and is configured to display a color.

Abstract: A method for sensing a target object using optical mode excitations in microresonators, comprises: preparing at least one cluster including at least two microresonators; obtaining some first spectra of the cluster; adsorbing the target object on a surface of the cluster; obtaining some second spectra of the cluster; and sensing the target object by comparing a lineshape of the first spectra with a lineshape of the second spectra.

Abstract: An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test chamber through the at least one sidewall and to induce a thermoelastic expansion in the one or more analytes, and a sensor configured to detect said thermoelastic expansion in the bodily fluid sample in the test chamber, the sensor configured to measure changes in optical reflectance that result from the thermoelastic expansion.

Abstract: A detection device and a method of detection are disclosed. The device may have a sensor array, a detector array, and a sensor controller. The sensor array may have a plurality of sensors, each sensor being responsive to a different analyte of interest. Each sensor may also be able to emit electromagnetic energy. For example, one or more of the sensors may include an LED. One or more of the sensors may include a sensing compound within a xerogel, which is responsive to an analyte of interest. In the method, one of the sensors is turned on, and one or more of the detectors are activated to receive electromagnetic energy emitted from the sensor.