Capsule Or Pelleted Or Tablet Patents (Class 424/408)
  • Patent number: 6287693
    Abstract: The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: September 11, 2001
    Inventors: John-Claude Savoir, Juan Angeles, Aurelio De Gyves, Abraham Gomez
  • Patent number: 6284278
    Abstract: Method for the production of encapsulated water-soluble granulated chemicals (fertilizers, salts, pesticides, etc.) with slow controlled release in water and soil with a uniform distribution of the chemicals in a melted thermoplastic, biodegradable and inert polymer composition, with subsequent formation of clots, granules or other shapes. The uniform cross-linked polymer compositions are produced by combining the process of polymerization of neutralized unsaturated carboxylic acids and the process of polycondensation of thiourea with formaldehyde, and the cross-linking of the obtained macromolecules with sulfur. Thus method makes it possible to obtain encapsulated chemicals with a wide range of use, containing up to 85% of the target product, with a gradual release which lasts for up to 180 and more days.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: September 4, 2001
    Assignee: Contrix Ltd.
    Inventors: Daniel Waldman, Emil Polyansky
  • Patent number: 6280723
    Abstract: The subject invention provides for a method for controlling termites by contacting the termites with a composition comprising Beuveria bassiana No. 447 (ATCC 20872).
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: August 28, 2001
    Assignee: University of Florida
    Inventors: Jerry L. Stimac, Sérgio Batista Alves
  • Patent number: 6280759
    Abstract: Tubules which contain an active agent in their lumen and compositions containing such microtubules are effective for providing a slow, controlled release of the active agent. Such microtubules are useful in the production of coating compositions for the protection of surfaces coming into contact with water, adhesive resins for the production of laminated wood products, and devices for dispensing pesticides.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: August 28, 2001
    Inventors: Ronald R. Price, Joel M. Schnur, Paul E. Schoen, Mary Testoff, Jacque H. Georger, Jr., Alan Rudolph, Robert F. Brady
  • Patent number: 6277393
    Abstract: A method for treating and/or preventing of cerebrovascular diseases, traumas and damages of the nervous system, which method includes local (topical) and/or systemic application of an effective amount of tetracycline and/or tetracycline derivative or a mixture of tetracycline and/or tetracycline derivative(s) (“active agent(s)”), optionally in a pharmaceutically-acceptable diluent, carrier or release system (“active compostition”).
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: August 21, 2001
    Assignee: Bioabsorbable Concepts, Inc.
    Inventors: Juha Yrjänheikki, Pertti Törmäl{umlaut over (a )}, Riitta Keinänen, Nina Vartiainen, Susanna Miettinen, Auvo Kaikkonen, Jari Koistinaho
  • Patent number: 6273929
    Abstract: The present invention provides an improved process for making extruded granules containing an agriculturally active ingredient.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: August 14, 2001
    Assignee: BASF Corporation
    Inventor: David G. Hobbs
  • Patent number: 6264985
    Abstract: A dry-coated tablet for controlled release of active substance, having an erodible core tablet (1) containing at least one active substance, and a substantially erosion-resistant shell consisting of a dry-coated layer (5), is characterized in that the dry-coated layer (5) has at least one opening (6), and one end of the core tablet (1) extends as far as the opening (6).
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: July 24, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventor: Karsten Cremer
  • Publication number: 20010008635
    Abstract: Disclosed is a method for the preparation of a composite material consisting of very fine inclusions of liquid, moderately to strongly hydrophobic active ingredients homogeneously dispersed in a thermoplastic matrix. The interface of the inclusions is fully covered by an emulsifier film.
    Type: Application
    Filed: January 9, 2001
    Publication date: July 19, 2001
    Applicant: GIVAUDAN SA
    Inventors: Christian Quellet, Marc Taschi, Johan Bernard Ubbink
  • Publication number: 20010006668
    Abstract: Compositions and methods for repelling an animal from an area or object are described. The compositions include an animal repellent dissolved or dispersed in a polymer where the repellent is released from the polymer over a period of time in an amount effective to repel an animal from the area. Capture of the repellent in the polymeric matrix allows for concentration of the repellent in an easily movable or removable device. Moreover, the repellent is not diluted by contact with water. The composition is provided in a usable form as a film, a sheet, a shaped article, pellets, or microparticles. The method for repelling an animal from an area or object includes preparing a device incorporating the above compositions and placing the device in an area or near or on an object desired to be protected. The devices can be manufactured by solvent evaporation, solvent removal, coextrusion, spray drying, and hot melt encapsulation.
    Type: Application
    Filed: August 6, 1998
    Publication date: July 5, 2001
    Inventor: LARRY R. BROWN
  • Patent number: 6251417
    Abstract: An inorganic antimicrobial composition has the formula AB2O4, wherein A and B are low temperature far infrared irradiating metals, A is Mg, Zn, Mn, Ni, Co, or Fe(II), B is Al, Cr(III), Mn(III) or Fe(III), and O is oxygen. An antimicrobial article is made by coating said composition on a porous honeycomb-shaped substrate. An organic antimicrobial article is made from a quarternary ammonium salt coated on a porous honeycomb-shaped substrate. Processes of making the antimicrobial articles are provided.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: June 26, 2001
    Inventors: Yen-Kuen Shiau, Chung-Hsun Wu
  • Patent number: 6251313
    Abstract: In the preparation of microcapsules having shell walls of organopolysiloxane and a core material, the shell walls are produced in situ by hydrolysis and polycondensation of organosilanes and/or their condensates having not more than 4 silicon atoms.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: June 26, 2001
    Assignee: Wacker-Chemie GmbH
    Inventors: Bernward Deubzer, Jochen Dauth
  • Patent number: 6248321
    Abstract: Microparticles such as propagules of eukaryotic biocontrol agents are encapsulated in cellular-scale polymer capsules that have a diameter similar to normal eukaryotic cells in a range of about 10 &mgr;m to about 400 &mgr;m. The microparticles are encapsulated by adding a hydrophobic dispersion medium such as a mixture of chloroform and hexane or a mixture of corn oil and n-hexadecane having a specific gravity of about 1 and containing an emulsifier such as lecithin to an aqueous suspension of the microparticles and a polymer matrix precursor such as alginate, agitating vigorously to form a stable emulsion of microscopic globules containing a microparticle, and adding the emulsion to an aqueous solution containing a polymerizing agent such as calcium chloride to polymerize and precipitate the globules to form microparticles encapsulated in polymer matrix capsules that may be of a teardrop shape having a length of 40-200% longer than the diameter.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: June 19, 2001
    Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of Natural Resources, Canadian Forestry Service
    Inventors: Richard Scott Winder, Jeffery Jerome Wheeler
  • Patent number: 6248364
    Abstract: A process for encapsulating a partially water-miscible organic material within a polyurea or polyurethane shell is provided utilizing a water-soluble tertiary amine in the reaction dispersion. Microcapsules and methods of using microcapsules are also provided.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: June 19, 2001
    Assignee: 3M Innovative Properties Company
    Inventors: Ashok Sengupta, Kent E. Nielsen, Galina Barinshteyn, Kai Li
  • Patent number: 6241994
    Abstract: The invention provides a solid TCMTB formulation for controlling the growth of at least one microorganism. The use of a solid TCMTB formulation, as compared to a liquid, minimizes user contact and is more readily packaged. A solid TCMTB formulation of the invention contains TCMTB adsorbed onto a water-soluble, salt carrier matrix, with the TCMTB present in an amount effective to control the growth of at least one microorganism, preferably in an aqueous system. Other microbicides and additives may also be incorporated into a solid TCMTB formulation of the invention. In a preferred embodiment, the formulation contains both TCMTB and one or more other microbicides (e.g., methylene bisthiocyanate (MTC)) and a water-soluble, salt carrier matrix. The TCMTB is adsorbed onto the water-soluble salt carrier matrix. The TCMTB and other microbicide are present in a combined antimicrobial amount effective for the control of at least one microorganism.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: June 5, 2001
    Assignee: Buckman Laboratories International, Inc.
    Inventors: James C. Lee, Luis Fernando Del Corral, Richard A. Clark, Pedro A. Bonilla
  • Patent number: 6235301
    Abstract: The invention provides a method and apparatus for controlling termites. The invention provides a more attractive and durable termite bait by providing a thin flat block of wood with grooves and impregnating the surface of the wood with a slow acting toxicant.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: May 22, 2001
    Assignee: FMC Corporation
    Inventors: James Bruce Ballard, Sherman H. Trimm
  • Patent number: 6225372
    Abstract: Particles have a hydrophilic core, for instance including an enzyme and a polymer, surrounded by a shell formed by interfacial condensation polymerisation in the presence of a polymeric stabiliser. Preferably the polymeric stabiliser is a random copolymer which will concentrate at the interface between oil and water and association by ionic interaction, condensation or otherwise is achieved between the stabiliser and one of the reactants before reaction with the other reactant. Dispersions of aqueous capsules in an aqueous medium are also disclosed.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: May 1, 2001
    Assignee: Ciba Speciality Chemicals Water Treatments, Limited
    Inventors: Mads Lykke, Kishor Kumar Mistry, Ole Simonsen, Kenneth Charles Symes
  • Patent number: 6217892
    Abstract: A regenerative water treatment composition and a process of making a regenerative water treatment composition by retaining a first bacteria killing material such as a zinc in fluid proximity with a second bacteria killing material such as silver chloride for insitu killing of bacteria to allow the silver chloride to continue to kill or damage bacteria that comes into contact with the silver chloride while the zinc carries away the dead bacteria.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: April 17, 2001
    Inventor: Joseph A. King
  • Patent number: 6203786
    Abstract: Compositions of &agr;-pinene in combination with at least one of &agr;-pinene oxide, myrtenol and nonanal are disclosed. In a preferred embodiment, the composition containing &agr;-pinene and &agr;-pinene oxide may additionally include trans-verbenol. A lure for Tomicus piniperda is made up of one or more release devices which dispense &agr;-pinene and at least one of &agr;-pinene oxide, myrtlenol nonanal and trans-verbenol. A method for attracting pine shoot beetles, Tomicus piniperda, uses the composition disclosed, optionally as part of a trap.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: March 20, 2001
    Assignee: The Research Foundation of State University of New York
    Inventors: Stephen A. Teale, Dariusz Czokajlo, Francis X. Webster
  • Patent number: 6200586
    Abstract: A suspension comprising an aqueous structured surfactant having suspended therein particles or droplets of a substantially water insoluble or sparingly soluble biocidal or agrochemical active substance in a weight ratio of total surfactant to said active substance of less than 20:1.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: March 13, 2001
    Assignee: Albright & Wilson Limited
    Inventors: Alan James Lambie, Brian John Akred, William John Nicholson, Jill Elizabeth Newton
  • Patent number: 6197321
    Abstract: A drain sanitizing article (9) for reducing microbiological activity in drain runoff areas having a housing (10), the housing having an inner wall (16) defining an inner opening (18) in the housing, an outer wall (12), and a bottom wall (14) defining a central cavity (15) in the housing (10), a tear strip (20) for destructibly removing the housing outer wall and a portion of the bottom wall (14), a handle (30) spanning the inner opening (18) of the housing (10) and joined to the inner wall (16) of said housing (10); and a chemical sanitizing agent (40).
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: March 6, 2001
    Assignee: Ecolab, Inc.
    Inventors: Francis L. Richter, James Wilson, Daniel E. Pedersen
  • Patent number: 6197320
    Abstract: Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked ionically or covalently to the ester chain which induces autocatalyzed hydrolysis.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: March 6, 2001
    Inventor: Shalaby W. Shalaby
  • Patent number: 6193988
    Abstract: A planting system involving a non-damaging stimulus (3) which is placed in the vicinity of a propagule (2) causes a naturally defensive substance (5) to be produced by the propagule. This substance may exist within an encapsulant (1) for a period of time so that the propagule may have enhanced disease control until it develops sufficiently to fend for itself. In one embodiment a large encapsulant surrounds a potato tuber. This encapsulant may include chitin to cause the release of chitinase through intermediate stimulants such as mRNA and activated carbon to absorb or release particular substances. The encapsulant is bound through the use of pentosan which acts with flaked chitin to achieve an outer casing and further protect the propagule both mechanically and chemically.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: February 27, 2001
    Inventors: Richard J. Stoner, II, Richard J. Stoner, Sr., James C. Linden, Kenneth W. Knutson, John H. Kreisher
  • Patent number: 6193990
    Abstract: The present invention relates to novel dry-blended extrudable pesticidal resin composition, extruded pesticidal resin compositions and pelletized pesticidal resin compositions comprising, as the active ingredient, O,O-diethyl S-[[1,1-dimethylethyl)thio]-methyl]phosphorodithioate, O,O-diethyl S-(ethylthio-methyl)phosphorodithioate or a pesticidal chemical wherein said technical grade of said pesticidal chemical has a dermal and/or oral LD50, as measured on rats or rabbits of less than 50 mg/kg. The novel compositions of the present invention are characterized by markedly reduced mammalian toxicity and increased pesticide stability and are essentially free of dust. Further, the present invention also relates to a process for preparing the present safened pesticidal resin compositions.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: February 27, 2001
    Assignee: American Cyanamid Co.
    Inventor: Joseph Fredrick Cannelongo
  • Patent number: 6180116
    Abstract: Histidine derivatives and processes of preparing the histidine derivatives. The histidine derivatives can be used to combat free radicals. The histidine derivatives may be used in cosmetic and/or dermatological compositions.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: January 30, 2001
    Assignee: L'Oreal
    Inventors: Michel Philippe, Thierry Bordier
  • Patent number: 6174538
    Abstract: Baits useful against diabroticine mature and immature beetles contain (a) an insecticide and (b) a feeding stimulant containing a cucurbitacin in a gelatin binder.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 16, 2001
    Assignee: Micro Flo Company
    Inventors: Keith L. Branly, James M. Gaggero, Chel W. Lew, Cathy S. Lamb
  • Patent number: 6174866
    Abstract: An antiparasitic medication for controlling and treating a wide variety of parasites in a herbivorous domesticated animal. The antiparasitic medication contains a mixture of ivermectin in a base of an alfalfa derivative. The antiparasitic medications are provided as pellets or fine granules or powders or other suitable feed application to avoid the use of injections in the animal, and to avoid stress and dangerous administration practices that could cause severe injury to both the care giver and the animal.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: January 16, 2001
    Inventor: Rosemary Smoter
  • Patent number: 6156329
    Abstract: Spent silver catalysts, from which the recoverable silver has already been stripped, was discovered to be useful for controlling microorganisms such as bacteria and fungi, including microorganisms in fluids such as water, or on surfaces to which coatings containing the stripped, spent silver catalysts are applied, and also in and on products or substrates in which the stripped, spent silver catalysts are incorporated.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: December 5, 2000
    Assignee: Ames Goldsmith Corporation
    Inventor: Ronald F. Davies
  • Patent number: 6156330
    Abstract: The present invention relates to chitin beads having a uniform and fine particle size and comprising microsporidian spores whose principal cell wall substance is chitin; chitosan beads comprising N-deacetylated chitin and having a uniform fine particle size; methods for preparing these beads; carriers comprising these beads; and a method for preparing microsporidian spores.Microsporidian spores are proliferated in insect's bodies or cultured cells to obtain chitin beads having the uniform and fine particle size and whose cell wall substance is mainly composed of chitin. The chitin as the major cell wall substance is subjected to N-deacetylation to give chitosan beads. When the insect is a larva of domesticated silkworm, microsporidian spores are proliferated by orally or percutaneously inoculating the spores into the 2nd instar domesticated silkworm larvae in a concentration of 5.times.10.sup.2 to 5.times.10.sup.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: December 5, 2000
    Assignee: Japan as represented by Director General of National Institute of Sericultural and Entomological Sciences Ministry of Agriculture, Forestry and Fisheries
    Inventors: Masuhiro Tsukada, Akira Shirata, Sho Ji Hayasaka
  • Patent number: 6156343
    Abstract: A controlled release preparation consisting of a tablet containing (a) a mixture of a drug and a water-soluble polymer, or a solid dispersion thereof, (b) polyvinylalcohol and (c) one or more salts selected from the group consisting of trisodium citrate, sodium sulfate and sodium chloride, and the tablet being coated with (d) a coating material consisting of a water-insoluble polymer and a water-soluble polymer and/or an enteric polymer, having the intentionally controllable release pattern and release rate of a drug and being suitable for administration of a drug once or twice a day.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: December 5, 2000
    Assignee: Akzo Nobel N.V.
    Inventors: Ryoichi Morita, Mitsutoshi Arahira, Ritsuko Honda, Yoshiteru Takahashi
  • Patent number: 6149843
    Abstract: Microcapsules containing a biologically active material which is sensitive to ultraviolet light are prepared which contain an ultraviolet light protectant selected from titanium dioxide, zinc oxide and mixtures thereof, suspended and thoroughly dispersed in a liquid.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: November 21, 2000
    Assignee: Zeneca Limited
    Inventors: Herbert B. Scher, Jin Ling Chen
  • Patent number: 6143312
    Abstract: Disclosed is a water-floating microbial pesticide comprising a microorganism, a water-in-oil type surfactant, oil, and powder having a low bulk specific gravity. Also disclosed are a method for producing the water-floating microbial pesticide and a method for using the water-floating microbial pesticide.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: November 7, 2000
    Assignee: Japan Tobacco Inc.
    Inventors: Masatoshi Gohbara, Hiroshi Tsukamoto
  • Patent number: 6136340
    Abstract: A food energy inhibitor for controlling rodents, such as rats and mice, comprises pellets of either crushed or dried corncobs, or, spent grain bound together with an attractant, such as molasses.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: October 24, 2000
    Inventor: James E. Chuhran
  • Patent number: 6113936
    Abstract: A microencapsulation method of a biologically active solid substance that is characterized by polymerizing a monomer that is polymerizable by condensation in a dispersion containing i) a solution containing a nonionic substance and ii) the biologically active solid substance that is insoluble or difficult to dissolve in said solution, wherein the nonionic substance is effective for dispersing the biologically active substance in said solution, is an effective method for producing a microencapsulated composition without aggregation.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: September 5, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshihiro Takebayashi, Nobuhito Ueda, Shugo Nishi
  • Patent number: 6113935
    Abstract: A suspension of microcapsules in an organic liquid, the microcapsules containing an aqueous phase, is produced by interfacial polymerization in the presence of a proton transfer catalyst of a water-in-oil emulsion in which the aqueous phase contains a urea/formaldehyde or melamine/formaldehyde prepolymer.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: September 5, 2000
    Assignee: ZENECA Limited
    Inventors: Maurius Rodson, Herbert B. Scher
  • Patent number: 6103251
    Abstract: A process for the administration of a flowable solid, semisolid, or liquid medium exhibiting a controlled release of at least one active substance to plants by means of injection using needle-free, pressure-actuated devices is characterized in that the medium comprises active substance-containing microparticles of a maximum size of 100 .mu.m including the following components:a) 0.5-70%-wt. of at least one active substance,b) 10-70%-wt. of at least one biodegradable polymer,c) up to 20%-wt. of formulation adjuvants.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: August 15, 2000
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Hans-Rainer Hoffmann, Malgorzata Kloczko, Michael Roreger
  • Patent number: 6093416
    Abstract: A stomach-action molluscicide including a metal complexone as an active ingredient. The term "complexone" as used herein refers to an organic ligand containing at least one iminodiacetic group --N(CH.sub.2 CO.sub.2 H.sub.2).sub.2 or two aminoacetic groups --NHCH.sub.2 CO.sub.2 H which form stable complexes with most cations. Preferably, the complexone is a derivative of ethylenediaminetetraacetic acid.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: July 25, 2000
    Inventor: Colin Leslie Young
  • Patent number: 6086917
    Abstract: The present invention is directed to a tablet, particularly a pharmaceutical dosage form, which contains an encapsulating agent comprising a modified starch which is prepared by enzymatic hydrolysis of a starch molecule after the preparation of a starch derivative containing a hydrophobic group or both a hydrophobic and a hydrophilic group, particularly octenyl succinic anhydride starch hydrolyzed by .beta.-amylase or glucoamylase. Such starch allows for good compressibility and hardness of a pharmaceutical dosage form. In addition, the starch may consistently allow for high load and retention of a variety of active agents as well as oxidative resistance.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: July 11, 2000
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Paul Trubiano, Dennis Boyd
  • Patent number: 6080418
    Abstract: A composition comprising two suspensions: A) an aqueous suspension of microcapsules containing biologically active materials and B) an adhesive suspension of adhesive microspheres. The composition is useful for adhering microencapsulated biologically active material onto an intended substrate.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: June 27, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: Ashok Sengupta, Kent E. Nielsen, Galina Barinshteyn, Kai Li, John P. Banovetz
  • Patent number: 6077522
    Abstract: Microcapsules containing a biologically active material which is sensitive to ultraviolet light are prepared which contain an ultraviolet light protectant selected from titanium dioxide, zinc oxide and mixtures thereof, suspended and thoroughly dispersed in a liquid.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: June 20, 2000
    Assignee: Zeneca Limited
    Inventors: Herbert B. Scher, Jin Ling Chen
  • Patent number: 6074689
    Abstract: Disclosed is a method for delivering an active protein or peptide to the colon. The steps of the method include providing a multiparticulate dosage core particle comprising 3 components, the total weight of the 3 components in dry form defining a batch size. The multiparticulate core particle is produced by the method comprising: a) providing an aqueous PEG solution, the dry weight of the PEG component representing from about 2.5% to about 15% of the batch size (weight/weight), the water component of the aqueous PEG solution representing approximately 30-60% of the batch size (weight/weight); b) providing a homogenous mixture of the active protein or peptide and microcrystalline cellulose, both in dry form, the active protein or peptide comprising from about 50% to about 95% of the batch size (weight/weight) and the microcrystalline cellulose comprising from about 2.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: June 13, 2000
    Assignee: ImmuCell Corporation
    Inventors: Michael S. Luck, Joseph H. Crabb
  • Patent number: 6071538
    Abstract: Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of:(a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states;(b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and(c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 6, 2000
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Evgueni Barantsevitch, Andrea Leone-Bay, Nai Fang Wang, Donald J. Sarubbi, Noemi B Santiago
  • Patent number: 6071529
    Abstract: The invention provides a method and apparatus for controlling termites. The invention provides a more attractive and durable termite bait by providing a thin flat block of wood with grooves and impregnating the surface of the wood with a slow acting toxicant.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: June 6, 2000
    Assignee: FMC Corporation
    Inventors: James Bruce Ballard, Sherman H. Trimm
  • Patent number: 6063393
    Abstract: The present invention relates to a process for the treatment of individual plants with solid shaped plant treatment agents which are introduced into the sap conduction paths of the plants, new solid shaped plant treatment agents and their production.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: May 16, 2000
    Assignee: Nihon Bayer Agrochem K.K.
    Inventors: Shin-ichi Tsuboi, Atsumi Kamochi, Nobuhiro Yamashita, Ikuya Saito, Yuzuru Wada, Kunihiro Isono, Shigeharu Koyama
  • Patent number: 6042843
    Abstract: A novel Plutella xylostella baculovirus (PxMNPV) which is useful for the control of insect pests has been isolated. A variety of insect pests may be controlled by application of an insecticidally effective amount of the baculovirus to the locus or vicinity of the target insect.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: March 28, 2000
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: Arthur H. McIntosh
  • Patent number: 6036970
    Abstract: The present invention relates to rodenticidal foams based on hydrophilic polymers, of the following composition:a) rodenticidal active compound,b) hydrophilic polymers having an average molecular weight of 2,000 to 60,000 (determined by means of gel permeation chromatography (GPC) from the series consisting of ling-chain polyurethanes, polyesters, polyester-polyols, polystyrenes, polybutadienes and maleic acid polymers, which are in each case modified in the polymer chain by carboxylic acid groups or amino groups,c) long-chain aliphatic C.sub.6 -C.sub.22 -fatty acids, such as palmitic acid, dodecanoic acid and stearic acid, or alkali metal, alkaline earth metal and ammonium salts thereof,d) and if appropriate further auxiliaries from the series consisting of dyestuffs, emulsifiers, solvents, perservatives, attractants and baits.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: March 14, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Kirkor Sirinyan, Manfred-Heinrich Schutte, Gerhard Hesse, Reiner Pospischil, Rainer Sonneck, Hans-Jurgen Schnorbach
  • Patent number: 6022501
    Abstract: The present invention provides pH-sensitive microcapsules, compositions containing them, methods for their preparation and methods for their use.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: February 8, 2000
    Assignee: American Cyanamid Company
    Inventors: Robin William Dexter, Brian Eric Benoff
  • Patent number: 6022552
    Abstract: A homogeneous mixture of solid granules cylindrical in shape of one or more groups which have substantially uniform diameters and a longitudinal length of no more than eight times the diameter with the average length being 1.5 to 4 times the diameter and wherein the diameters vary from one group to another by no more than 30%.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: February 8, 2000
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Philip Alexander Brown, Luann Marshall Pugh
  • Patent number: 6022480
    Abstract: The present invention comprises devices and methods for treating a standing water system comprising devices for the administration to the standing water system an admixture comprising calcium hypochlorite and borate salts and acids through a perforated distribution device. The method of treating a standing water system more efficiently provides free chlorine to the system, stabilizes the pH of the standing water system, and reduces the undesired side effects of the addition of calcium hypochlorite alone.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: February 8, 2000
    Assignee: The John Girvan Company, Inc.
    Inventors: Don H. Girvan, Philip R. Reynolds
  • Patent number: 6019971
    Abstract: The invention is directed to a method of treating a T cell-mediated autoimmune disease in animals, including humans, by the oral administration of autoantigens, fragments of autoantigens, or analogs structurally related to those autoantigens, which are specific for the particular autoimmune disease. The method of the invention includes both prophylactic and therapeutic measures.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 1, 2000
    Assignee: AutoImmune Inc.
    Inventors: Howard L. Weiner, David A. Hafler
  • Patent number: 6015571
    Abstract: Microcapsules containing a suspension of a soild, biologically active compound in an organic, water-immiscible liquid and processes for their preparation.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: January 18, 2000
    Assignee: Zeneca Limited
    Inventors: Herbert B. Scher, Jin Ling Chen