Capsule Or Pelleted Or Tablet Patents (Class 424/408)
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Patent number: 6916481Abstract: The invention relates to an active substance vector multiparticulate system and to the production and use thereof. The object of the invention is an active-substance vector multiparticulate system comprising one or several active substances included in a hydrophilic organic matrix comprising at least one hydrosoluble and/or hydrodispersable anionic polymer which is insolubilized by a metallic cation. The invention can be specifically used in the food industry, detergents and agrochemistry.Type: GrantFiled: April 12, 2000Date of Patent: July 12, 2005Assignees: Aventis CropScienceInventors: Christian Prud'Homme, Etienne Fleury, Jean-Paul Michalon, Robert Zerrouk
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Patent number: 6913767Abstract: Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with antigen.Type: GrantFiled: April 30, 1997Date of Patent: July 5, 2005Assignee: Genentech, Inc.Inventors: Jeffrey L. Cleland, Amy Lim, Michael Frank Powell
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Patent number: 6914141Abstract: Pharmaceutical tablets comprising clopidogrel bisulfate and a lubricant selected from zinc stearate, stearic acid, and sodium stearyl fumarate.Type: GrantFiled: November 4, 2002Date of Patent: July 5, 2005Inventor: Bernard Charles Sherman
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Patent number: 6905679Abstract: The present invention relates to the use of a supernatant of lactic acid bacteria or of Bifidobacteria capable of preventing colonization of intestinal cells by Giardia intestinalis, for the preparation of an ingestable carrier for the treatment and/or prophylaxis of disorders associated with the colonization of the gut by Giardia intestinalis. The present invention also pertains to specific strains of Bifidobacterium having the above traits and to the ingestable carrier, such as a food or pharmaceutical composition containing such supernatant or the microorganisms.Type: GrantFiled: October 13, 2000Date of Patent: June 14, 2005Assignee: Nestec S.A.Inventors: Eduardo Schiffrin, Pablo Perez
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Patent number: 6881745Abstract: The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the form of a solid dispersion of the practically insoluble drug and a polymer having acidic functional groups, and the composition may in vitro form a suspension.Type: GrantFiled: June 16, 2003Date of Patent: April 19, 2005Assignee: F H Faulding & Co LimitedInventors: David Hayes, Angelo Mario Morella
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Patent number: 6878309Abstract: A controlled-release additive composition for use in aqueous systems. The composition comprises a core containing at least one additive component and a polymeric coating encapsulating said core. The controlled released cooling additive composition slowly releases the additive components to aqueous system, thereby delivering an effective concentration level of additive components over an extended period.Type: GrantFiled: February 12, 2001Date of Patent: April 12, 2005Assignee: Dober Chemical Corp.Inventors: Thomas J. Blakemore, Yu-Sen Chen
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Patent number: 6875840Abstract: Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.Type: GrantFiled: September 23, 2003Date of Patent: April 5, 2005Assignee: Duke UniversityInventors: Jonathan S. Stamler, Eric J. Toone, Richard S. Stack
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Patent number: 6875440Abstract: Termites can be controlled by applying an effective amount of N-[2-chloro-3,5-bis(trifluoromethyl)phenyl]-N?-(2,6-difluorobenzoyl)urea supported on cellulose.Type: GrantFiled: February 25, 2003Date of Patent: April 5, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Seietsu Aki, Hiromi Eguchi
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Patent number: 6869612Abstract: A purified shilajit composition is provided herein from native shilajit. The composition has an abundance of bioactive components, particularly, at least 0.3%, preferably 0.4-1%, by weight, oxygenated dibenzo-?-pyrones and at least 60%, preferably 65-70%, by weight of fulvic acids of low-to-medium molecular weight ({overscore (M)}n of 700-2000) with an E4/E6 ratio of 8-10 at ?465-665 nm, and whose 2% aqueous solution has a pH of ?7. Personal care, pharmaceutical and nutritional use formulations of the purified shilajit composition also are described.Type: GrantFiled: August 1, 2002Date of Patent: March 22, 2005Assignees: Natreon, Inc., Indian Herbs Research & Supply Company Ltd.Inventor: Shibnath Ghosal
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Patent number: 6861064Abstract: A novel method of encapsulating an active substance in a biodegradable polymer, which comprises: a) dissolving said biodegradable polymer in an organic solvent therefor; b1) dispersing said active substance in the organic solution obtained in step a) to provide a dispersion with the active substance as the inner phase thereof; or alternatively b2) emulsifying said active substance, dissolved in water or other aqueous solvent therefor, in the organic solution obtained in step a) to provide an emulsion with the active substance as the inner aqueous phase thereof; and c) subjecting the dispersion obtained in step b1), or alternatively the emulsion obtained in step b2), to an encapsulation operation with an aqueous polyethylene glycol solution as a continuous phase to provide micro- or nanoparticles having the active substance encapsulated therein. Sustained release particles obtainable thereby.Type: GrantFiled: September 24, 1998Date of Patent: March 1, 2005Assignee: Jagotec AGInventors: Timo Laakso, Mats Reslow
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Patent number: 6852329Abstract: An effective, readily ingested molluscicidal bait poison includes a mollusc bait and a second component. The second component can contain a transition metal compound and a complexing agent, and/or the complex of a transition metal compound and a complexing agent. The complexing agent is preferably iminodisuccinic acid (IDS), including sodium IDS (IDS Na-Salt), iminodifumaric acid (IDF), iminoditartaric acid (IDT), iminodimaleic acid (IDMAL), ethylenediaminedifumaric acid (EDDF), ethylenediaminedimalic acid (EDDM), iminodimalic acid (IDM), ethylenediamineditartaric acid (EDDT), ethylenediaminedimaleic acid (EDDMAL), and salts thereof.Type: GrantFiled: November 6, 2002Date of Patent: February 8, 2005Assignee: W. Neudorff GmbH KGInventors: George S. Puritch, Andreas Prokop, David S. Almond, Robert Matson
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Patent number: 6852328Abstract: A method and device are disclosed which prevents the decay and deterioration of wooden objects caused by pests by using a controlled release device. This controlled release device utilizes polymers which incorporate pesticides. In the disclosed method, the controlled release device is placed in contact with the wood of the wooden object. The pesticide is gradually released from the device and absorbed into the wood structure. The pesticide absorbed by the wood creates a barrier or an exclusion zone to penetration by inserts. The controlled release device maintains a minimal effective level of pesticide in the barrier or exclusion zone for a predetermined period of time.Type: GrantFiled: December 20, 1996Date of Patent: February 8, 2005Assignee: Battelle Memorial Institute K1-53Inventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton
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Patent number: 6852333Abstract: The invention relates to compositions and methods for promoting production gains in animals, and of enhancing the efficacy of therapeutic agents. The gains are achieved through reduction in stress, including through the use of antistress agents. Compositions comprising therapeutic agents such as anthelmintics, and antistress agents are provided.Type: GrantFiled: March 13, 2000Date of Patent: February 8, 2005Assignee: The Horticulture and Food Research Institute of New Zealand LimitedInventor: Christian John Cook
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Patent number: 6849214Abstract: An improved sintered porous thermoplastic filter incorporating a second thermoplastic treated with a non-leaching antimicrobial agent for the purification of liquids. The method of making the filter is also disclosed.Type: GrantFiled: May 31, 2002Date of Patent: February 1, 2005Assignee: Microban Products CompanyInventor: Arvind S. Patil
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Patent number: 6843993Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ?14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.Type: GrantFiled: July 27, 2001Date of Patent: January 18, 2005Assignee: Ramot at Tel-Aviv University, Ltd.Inventors: Itzhak Ofek, Ervin Weiss, Yoel Kashman, Janina Goldhar, Nathan Sharon
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Patent number: 6803051Abstract: A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of time.Type: GrantFiled: July 13, 1999Date of Patent: October 12, 2004Assignee: Battelle Memorial Institute K1-53Inventors: Peter Van Voris, Dominic A. Cataldo, Frederick G. Burton
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Patent number: 6797277Abstract: Water-dispersible, extruded granules for delivering agricultural chemicals, such as pesticides or non-pesticidal materials, to a crop. The granules are extrusion-formed from a blended composition including at least one active chemical ingredient, a solid carrier, and a binder. The active chemical ingredient may or may not be micro-encapsulated. The binder may be added directly to the composition or applied as a coating to the granules after the extrusion process. The binder reduces attrition, chemical volatility, and phytotoxicity. The granules are applied to a crop field by aerial means. The dense granules display good vertical drop characteristics, with little drift. If the crop field has standing water, the water-dispersible granules sink and break up, effecting dispersion of the chemical ingredient. When applied to a dry field, the subsequent exposure to water to the granules effects the same dispersal of chemical ingredient.Type: GrantFiled: May 29, 2002Date of Patent: September 28, 2004Assignee: Wilbur-Ellis CompanyInventors: John L. Heier, David T. Schulteis
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Patent number: 6790453Abstract: Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by: (i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and (ii) extruding the melted mixture, to obtain an extruded mixture.Type: GrantFiled: March 14, 2002Date of Patent: September 14, 2004Assignee: McCormick & Company, Inc.Inventors: Michael A. Porzio, Dmitriy Zasypkin
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Patent number: 6780507Abstract: A method is described for the formation of microcapsules which contain a liquid composition in the core, which is surrounded by a polymeric shell, membrane, or coating. The microcapsules are produced by simultaneously extruding the liquid core material along with a polymerizable liquid through concentrically-aligned nozzles to form spherically-layered biliquid droplets, followed by energy input in the form of heat or light which causes polymerization of the outer layer. The capsules formed by this method are capable of containing a variety of liquid materials having a composition ranging from completely aqueous to completely non-aqueous.Type: GrantFiled: February 9, 2001Date of Patent: August 24, 2004Assignee: Analytical Research Systems, Inc.Inventors: William Toreki, Ara Manukian, Rudolph Strohschein
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Patent number: 6780838Abstract: The broadest aspect of the invention is a composition and method of treatment of fungal pathologies of the oral cavity or fungal growth on the surface of dentures. A preferred embodiment of the is a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV(SEQ ID NO: 1), HFRWGKPV(SEQ ID NO: 3), and SYSMEHFRWGKPV (SEQ ID NO: 4) in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole, imconazole and fluconazole.Type: GrantFiled: January 29, 2001Date of Patent: August 24, 2004Assignee: Zengen, Inc.Inventors: James M. Lipton, Anna P Catania
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Patent number: 6776996Abstract: The present invention provides improved coated pesticidal matrices and a process for their preparation. The present invention also provides a wettable powder pesticidal composition containing the improved coated pesticidal matrices.Type: GrantFiled: June 9, 1998Date of Patent: August 17, 2004Assignee: BASF AktiengesellschaftInventors: Guanglin Sun, Fakhruddin Ahmed, Bruce Christian Black
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Publication number: 20040137031Abstract: The present invention is directed to controlling the release of microencapsulated materials. The microcapsules have a polymer shell, the precursors of which are selected to adjust the rate at which core materials are released. The present invention is further directed to the formulation of said microcapsules in aqueous dispersions, and to the manufacture of said microcapsules.Type: ApplicationFiled: December 5, 2003Publication date: July 15, 2004Applicant: Monsanto Technology LLCInventors: Michael E. Seitz, Ronald J. Brinker
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Publication number: 20040137030Abstract: A solid formulation of an agrochemical is prepared by forming a melt containing at least one agrochemical and at least one thermoplastic binder having a melting point or glass temperature of greater than 35° C., briquetting the melt by dividing it into drops in a first step and solidifying these drops by cooling in a second step, characterised in that the melt additionally comprises a liquid non-volatile solvent for the agrochemical.Type: ApplicationFiled: February 4, 2004Publication date: July 15, 2004Inventors: Richard David Knott, Rowena Roshanthi Landham, Eric Van Der Drift
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Patent number: 6761897Abstract: Chemically stable, insecticidally active pellets having a low moisture content and at least about 95% active ingredient are described, as well as a method for manufacturing them. The active ingredient is selected from a class of N-hydrocarboyl phosphoroamidothioate and phosphoroamidodithioate compounds as described in the specification. The pellets generally have a moisture content of about 0.5% by weight or less, preferably less than about 0.3% by weight. The pellets can be produced by one of two types of processes as described in detail, including a high pressure axial extrusion process and a low pressure basket extrusion process.Type: GrantFiled: November 20, 2001Date of Patent: July 13, 2004Assignees: Valent U.S.A. Corporation, Arvesta CorporationInventors: Gary L. Cummings, Young-Jin Lee, James L. Platt, Jr., Matthew Hikade, Vernell Stornes
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Patent number: 6756428Abstract: A microbe-inhibiting (MI) compound is incorporated into a biodegradable polymer composition most preferably, a starch-based polymer, to inhibit microbial growth and to attenuate the biodegradation of the polymer composition. Such a composition is used to manufacture any of a number of articles, particularly those that come in contact with foods such as foam containers and fruit shock absorber nets as well as packing materials such as loose fill pellets.Type: GrantFiled: March 12, 2003Date of Patent: June 29, 2004Assignee: Seefar Technologies, IncorporatedInventor: Matthew Denesuk
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Publication number: 20040120976Abstract: A microencapsulated insecticidal composition comprising a pyrethrin encapsulated in a wall formed of a synthetic polymer and having an average particle diameter of 5 to 100 &mgr;m and wall thickness of 0.03 to 1 &mgr;m is effective for controlling insects.Type: ApplicationFiled: November 7, 2003Publication date: June 24, 2004Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Keiichiro Inui, Takahiro Shigemura
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Patent number: 6753338Abstract: Methods and compositions are disclosed utilizing the optically pure (−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (−) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (−) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.Type: GrantFiled: July 29, 2002Date of Patent: June 22, 2004Assignee: Sepracor Inc.Inventor: James W. Young
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Patent number: 6747164Abstract: The present invention relates to the use of an amino compound, which is an esteramine or an amidoamine surfactant with improved biodegradability, as an adjuvant for agrochemically active compounds such as pesticides or fertilizers. The adjuvant has Formula (I) where R1 is an aliphatic group containing 7-22 carbon atoms; EO is an ethyleneoxy group; Y is 0 or NH; R2 and R3 is independently CH2CH2OH or an alkyl group with 1-5 carbon atoms, preferably 1-3 carbon atoms; n is a number between 0-10; x is a number 0-1 provided that when Y is O, then x is 1, and when Y is NH, then x is O; and m is a number 2-6, preferably 2-3, provided that when Y is NH, then m is 3-6, preferably 3; or an adduct obtained by reacting one mole of the compound with 1-5 moles of an alkylene oxide having 2-3 carbon atoms.Type: GrantFiled: March 25, 2003Date of Patent: June 8, 2004Assignee: Akzo Nobel N.V.Inventors: Bodil Gustavsson, Burkhard Weuste
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Patent number: 6746684Abstract: A microcapsule characterized by comprising a solid pesticide as a core material coated with a wall material which is a resin formed by polycondensation of a sparingly water-soluble melamine-formaldehyde resin type prepolymer (said sparingly water-soluble melamine-formaldehyde resin type prepolymer dissolves 2000 g or less of water therein per 100 g of solid component of the prepolymer at +25° C.) in the presence of a dispersant which is a condensation product of naphthalenesulfonic acid and/or alkylnaphthalenesulfonic acid and formaldehyde or a salt thereof, a method for producing said microcapsule, and a method for applying said microcapsule are disclosed.Type: GrantFiled: October 15, 2001Date of Patent: June 8, 2004Assignee: Syngenta Crop Protection, Inc.Inventors: Kenichi Kitagaki, Hironori Kataoka
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Patent number: 6737081Abstract: The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.Type: GrantFiled: February 26, 2003Date of Patent: May 18, 2004Inventors: John-Claude Savoir, Juan Angeles, Aurelio De Gyves, Abraham Gomez
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Patent number: 6723331Abstract: Termite controlling composition is provided, which has an excellent residual effect and is suitable for applying to soil. The composition comprises (i) at least one pyrethroid compound selected from the group consisting of &agr;-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate and 3-(2,2-dihalovinyl)-2,2-dimethylcyclopropanecarboxylic acid 3-phenoxybenzyl alcohol ester, the alcohol of which may have a cyano group at &agr;-position and (ii) N-(ethylhexyl)-bicyclo[2.2.1] hept-5-en-2,3-dicarboximide as active ingredient.Type: GrantFiled: June 7, 1995Date of Patent: April 20, 2004Assignee: Sumitomo Chemical Company, LimitedInventors: Hayato Teshima, Takaaki Itoh
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Patent number: 6713077Abstract: A method of preventing damage to the shoots and foliage of a plant by a pest includes treating the seed from which the plant grows with a composition that includes at one pyrethrin or synthetic pyrethroid. In another embodiment, the pesticide is not limited to pyrethrins or synthetic pyrethroids when the seed is a transgenic seed having at least one heterologous gene encoding for the expression of a protein having pesticidal activity against a first pest and the pesticide has activity against at least one second pest. Treated seeds are also provided.Type: GrantFiled: July 20, 2000Date of Patent: March 30, 2004Assignee: Monsanto Technology, LLCInventor: Frank C. Kohn
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Patent number: 6709681Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions. The invention also provides delivery systems for the topical medicament.Type: GrantFiled: June 11, 1999Date of Patent: March 23, 2004Assignee: Aberdeen UniversityInventors: Nigel Benjamin, Hamish Dougall, Anthony Ormerod
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Patent number: 6703036Abstract: A stomach-action molluscicide, which includes a metal complexone and a suitable additive for enhancing the molluscicidal activity of the metal complexone. The additive may be selected from a surfactant or an additional source of ferric ions. Examples of the surfactant include sodium dodecyl sulphate or sorbitan monostearate, while an example of the additional source of ferric ions is ferric orthophosphate.Type: GrantFiled: May 15, 2000Date of Patent: March 9, 2004Inventor: Colin Leslie Young
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Patent number: 6703035Abstract: This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.Type: GrantFiled: March 1, 2002Date of Patent: March 9, 2004Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 6682751Abstract: A granular controlled-release pesticide comprising “core” granules such as ammonium sulfate, an inner polymer membrane formed in situ on said granules of ammonium sulfate, an acephate pesticide applied to the inner polymer membrane on the core granules, and an outer controlled-release polyurethane membrane formed in situ on said pesticide to permit controlled release of the pesticide.Type: GrantFiled: September 12, 2001Date of Patent: January 27, 2004Assignee: RLC Technologies, L.L.C.Inventors: Garrard L. Hargrove, John H. Detrick
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Patent number: 6682755Abstract: A method for controlling insects, such as ants, comprising orally administering to the insects an effective amount of a food energy inhibitor consisting essentially of cellulose spent grain in a particulate form, mixed with an attractant without the addition of an insecticide, pesticide or poison.Type: GrantFiled: October 24, 2000Date of Patent: January 27, 2004Inventor: James E. Chuhran
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Patent number: 6682752Abstract: Compositions for mole control comprise an active ingredient capable of repelling moles prepared such that it can be distributed in a solid form over the mole-invaded areas.Type: GrantFiled: December 19, 2000Date of Patent: January 27, 2004Inventor: Steven P. Wharton
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Patent number: 6680065Abstract: The present invention relates to shaped articles which release agrochemical active compounds, are used for treatment of woody plants and are employed in a hollow preformed in the woody plant, are of a volume which fills the volume of the hollow to the extent of 10 to 95%, are of a volume which does not increase during the period of use to the extent that the preformed hollow space is filled completely, comprise a) agrochemical active compounds, b) water-insoluble thermoplastically processable polymers, c) water-soluble polymers and d) if appropriate further auxiliaries.Type: GrantFiled: April 24, 2001Date of Patent: January 20, 2004Assignee: Bayer AktiengesellschaftInventors: Wolfgang Podszun, Uwe Priesnitz, Jürgen Hölters, Bodo Rehbold, Rafel Israels
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Patent number: 6676954Abstract: Solid compositions containing low water solubility 3-isothiazolone compounds and carbon-based adsorbents that do not rapidly release the 3-isothiazolone when added to a locus to be protected are disclosed. In particular, methods of controlling or inhibiting the growth of marine organisms using the controlled release solid compositions in paints and coatings for marine structures is disclosed.Type: GrantFiled: March 19, 2001Date of Patent: January 13, 2004Assignee: Rohm and Haas CompanyInventors: David Junhui Dai, Gary Lewis Willingham
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Patent number: 6677293Abstract: The invention relates to a method for increasing the efficiency of surfactants and to a method for suppressing lamellar mesophases in microemulsions. Additive block co-polymers with a water-soluble block A and a water-insoluble part B are added to the surfactants. The efficiency of surfactants can be in-creased to a substantial extent by using said compounds as additives. The formation of undesirable lamellar mesophases in microemulsions is suppressed by adding said block co-polymers.Type: GrantFiled: June 11, 2001Date of Patent: January 13, 2004Assignee: Forschungszentrum Jülich GmbHInventors: Jürgen Allgaier, Lutz Willner, Dieter Richter, Britta Jakobs, Thomas Sottmann
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Patent number: 6663895Abstract: The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.Type: GrantFiled: May 29, 2002Date of Patent: December 16, 2003Inventors: John-Claude Savoir, Juan Angeles, Aurelio De Gyves, Abraham Gomez
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Publication number: 20030224031Abstract: Water-dispersible, extruded granules for delivering agricultural chemicals, such as pesticides or non-pesticidal materials, to a crop. The granules are extrusion-formed from a blended composition including at least one active chemical ingredient, a solid carrier, and a binder. The active chemical ingredient may or may not be micro-encapsulated. The binder may be added directly to the composition or applied as a coating to the granules after the extrusion process. The binder reduces attrition, chemical volatility, and phytotoxicity. The granules are applied to a crop field by aerial means. The dense granules display good vertical drop characteristics, with little drift. If the crop field has standing water, the water-dispersible granules sink and break up, effecting dispersion of the chemical ingredient. When applied to a dry field, the subsequent exposure to water to the granules effects the same dispersal of chemical ingredient.Type: ApplicationFiled: May 29, 2002Publication date: December 4, 2003Inventors: John L. Heier, David T. Schulteis
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Patent number: 6645192Abstract: A parasiticidal pellet system which delivers both immediate and long term control of parasite infestation in an animal as part of a single implant procedure. The system includes an implanter apparatus for subcutaneously implanting parasiticidal pellets in an animal through the bore of a hypodermic needle which is operably coupled to a pellet magazine, and a plurality of pellets sized to be implanted through the needle and positioned in the magazine for selective alignment of a pellet with the needle. The pellets include at least one immediate release parasiticidal agent first dose pellet and at least one extended release parasiticidal agent dose second pellet. The combined pellets are packaged in the magazine in sequential order for simultaneous delivery of an immediate dose and an extended dose as part of a single injection.Type: GrantFiled: September 30, 1998Date of Patent: November 11, 2003Assignee: Ivy Animal Health, Inc.Inventors: Dale C. Kenison, Stanford R. Spurlin
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Patent number: 6646014Abstract: The present invention concerns a method for the control of various diseases in bee-hives by applying to the bee-hives an effective amount of an essential oil in a slow-release formulation whereby the term oils embraces but is not limited to oils extractable from plant or the essential component thereof such as monoterpenes like menthol, geraniol, thymol, myrcene, citral, limonene, carene, camphor, eugenol, or cineol (eucalyptol); natural oils like lemon oil, eucalyptus oil, or neem oil; or organic acids like formic acid, acetic acid or oxalic acid. Most preferred are monoterpenes like thymol or menthol. Most preferred is thymol.Type: GrantFiled: January 22, 2001Date of Patent: November 11, 2003Assignee: Vita (Europe) LimitedInventor: Max Watkins
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Patent number: 6641828Abstract: Microbiological control in aqueous media and/or eradication or reduction of biofilm on a surface in contact with such media is achieved by introducing into the aqueous medium a microbiocidally effective quantity of one or more 1,3-dibromo-5,5-dialkylhydantoins where one of the alkyls is methyl and the other is a C1-4 alkyl, wherein (i) the molar quantity of 1,3-dibromo-5,5-dialkylhydantoin introduced is less than the molar quantity of N,N′-bromochloro-5,5-dimethylhydantoin that would be required to effect the same degree of microbiological control in that medium, (ii) the molar quantity of the 1,3-dibromo-5,5-dialkylhydantoin introduced releases an amount of “free chlorine” that is greater than the amount of “free chlorine” that would be released in that medium by an equimolar quantity of N,N′-bromochloro-5,5-dimethylhydantoin, and (iii) the amount of “free chlorine” released by the quantity of the 1,3-dibromo-5,5-dialkylhydantoin introduced is greater than theType: GrantFiled: February 2, 2001Date of Patent: November 4, 2003Assignee: Albemarle CorporationInventors: Jonathan N. Howarth, Christopher J. Nalepa, Michael J. Sanders
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Patent number: 6638536Abstract: The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.Type: GrantFiled: January 15, 2002Date of Patent: October 28, 2003Inventors: John-Claude Savoir, Juan Angeles, Aurelio De Gyves, Abraham Gomez
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Patent number: 6638959Abstract: Microbiological control is achieved by continuously and inexpensively dosing water in contact with biofilm, or that comes into contact with biofilm, using a highly effective biocide that provides very effective microbiocidal control of planktonic microorganisms and of biofilm species, even where the biofilm infestations have been in existence for long periods of time and thus have encased themselves in a substantial quantity of slimy defensive polysaccharide layers or films. In addition, the biocide used makes possible significant reduction in copper and/or iron surfaces in contact with the water as compared to N,N′-bromochloro-5,5-dimethyl hydantoin. Still other advantages are made possible by the described technology.Type: GrantFiled: October 9, 2001Date of Patent: October 28, 2003Assignee: Albemarle CorporationInventors: Jonathan N. Howarth, Christopher J. Nalepa, Michael J. Sanders, David L. Shelton
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Publication number: 20030194418Abstract: A treatment capsule (10) comprising an outer membrane (11), an inner volume (12), and a topical treatment that fills the inner volume (11). In some embodiments, the treatment capsule (10) contains a pesticide for livestock. The method of selecting an animal, determining a dosage to be administered, determining the number of capsules to be administered, and propelling the number of treatment capsules at the selected animal.Type: ApplicationFiled: April 12, 2002Publication date: October 16, 2003Inventor: Donald George Hilton
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Patent number: 6632531Abstract: A method of forming, by polymerization in an aqueous dispersion at pressures in excess of one atmosphere, a plurality of porous particles having at least one polymeric phase and, additionally, having a pore filling phase containing a fugitive substance is disclosed. Replacement of the fugitive substance with a gas is further disclosed. Gas-filled porous particles and their aqueous dispersions are also disclosed.Type: GrantFiled: December 13, 2001Date of Patent: October 14, 2003Assignee: Rohm and Haas CompanyInventor: Robert Mitchell Blankenship