Abstract: An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles.
Type:
Grant
Filed:
November 13, 2003
Date of Patent:
October 28, 2014
Assignee:
pSivida US, Inc.
Inventors:
Kang-Jye Chou, Hong Guo, Paul Ashton, Robert W. Shimizu, David A. Watson
Abstract: A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive incorporated into the first biodegradable and/or bioabsorbable material. The second biodegradable and/or bioabsorbable material has a degradation rate that is faster than the degradation rate of the first biodegradable and/or bioabsorbable material such that the structure experiences a period of accelerated degradation upon release of the degradation additive following sufficient degradation of the second biodegradable and/or bioabsorbable material.
Abstract: Provided is a method for treating a periodontal disease affecting a periodontal pocket of a patient. The method includes inserting an oral delivery device into the periodontal pocket at a frequency of about once every 4 days to about once every 6 weeks. The oral delivery device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, including a therapeutically effective amount of at least one anti-inflammatory agent, at least one antibacterial agent, or the combination of at least one anti-inflammatory agent and at least one antibacterial agent.
Type:
Grant
Filed:
October 20, 2011
Date of Patent:
October 21, 2014
Assignee:
Dexcel Pharma Technologies Ltd.
Inventors:
Avi Avramoff, Eyal Shoshani, Adel Penhasi, Dan Oren
Abstract: Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
Type:
Grant
Filed:
November 13, 2008
Date of Patent:
October 14, 2014
Assignee:
Intersect ENT, Inc.
Inventors:
Donald J. Eaton, Thomas R. Tice, David B. Downie, Patrick A. Arensdorf, Rodney Brenneman, Danielle L. Biggs
Abstract: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.
Type:
Grant
Filed:
January 3, 2013
Date of Patent:
October 14, 2014
Assignee:
Technion Research & Development Foundation Limited
Abstract: A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii) an end-graft polymer chain comprising a polylactone. Also disclosed are a method for treating bleeding from bone or bony structures using the composition, a method for filling a void or correct a defect in a bone using the composition, and a method for producing the biocompatible, polymeric composition of the present application.
Type:
Grant
Filed:
April 12, 2012
Date of Patent:
October 14, 2014
Assignee:
Poly-Med, Inc.
Inventors:
Kenneth David Gray, Jr., Michael Scott Taylor
Abstract: The subject invention provides a drug delivery system comprising at least one compartment consisting of (i) a drug-loaded thermoplastic polymer core, (ii) a drug-loaded thermoplastic polymer intermediate layer and (iii) a non-medicated thermoplastic polymer skin covering the intermediate layer, wherein said intermediate layer is loaded with (a) crystals of a first pharmaceutically active compound and with (b) a second pharmaceutically active compound in dissolved form and wherein said core is loaded with said second compound in dissolved form.
Type:
Grant
Filed:
November 9, 2012
Date of Patent:
October 14, 2014
Assignee:
Merck Sharp & Dohme B.V.
Inventors:
Rudolf Johannes Joseph Groenewegen, Wouter de Graaff, Henk Jan Out
Abstract: The present invention relates to an implantable paste comprising bioactive glass spheres having a size distribution of 50-425 ?m, low molecular weight polyethylene glycol having a molecular weight range of 200-700 g/mol, medium molecular weight polyethylene glycol having a molecular weight range of 700-2500 g/mol and high molecular weight polyethylene glycol having a molecular weight range of 2500-8000 g/mol, with the proviso that the molecular weight of the low molecular weight polyethylene glycol and of the medium molecular weight polyethylene glycol differ from each other by at least 80 g/mol and that the molecular weight of the medium molecular weight polyethylene glycol and of the high molecular weight polyethylene glycol differ from each other by at least 300 g/mol.
Type:
Grant
Filed:
November 12, 2010
Date of Patent:
October 14, 2014
Assignee:
Bonalive Biomaterials Oy
Inventors:
Jukka Tuominen, Timo Lehtonen, Fredrik Ollila
Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
Type:
Grant
Filed:
March 12, 2010
Date of Patent:
October 14, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.
Type:
Application
Filed:
June 23, 2014
Publication date:
October 9, 2014
Inventors:
Thomas J. WEBSTER, Hicham FENNIRI, Usha Devi HEMRAZ
Abstract: A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.
Type:
Application
Filed:
October 12, 2012
Publication date:
October 2, 2014
Applicant:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Jordan J. Green, Corey J. Bishop, Daniel Peng, Stephany Yi Tzeng
Abstract: Provided in one embodiment is an implantable support material for culturing cells, wherein at least some of the cells substantially maintain at least one of (i) phenotype and (ii) genotype thereof after being cultured on the support material.
Type:
Application
Filed:
June 13, 2014
Publication date:
October 2, 2014
Inventors:
Gonzalo Serafica, Constance Ace, Jessica Donlin, Junping Wang
Abstract: A matrix for tissue growth includes: (a) a first layer including a first assembly of collagen fibers; (b) a plurality of projections on a top surface of the first layer; and (c) a second layer bonded to a bottom portion of the first layer and including a second assembly of collagen fibers, wherein the second layer has a lower density than the first layer, and the matrix includes pores effective to support cell growth into the matrix. A method for providing the matrix is also described.
Type:
Grant
Filed:
January 12, 2007
Date of Patent:
September 30, 2014
Assignee:
Integra LifeSciences Corporation
Inventors:
Simon J. Archibald, Mark Spilker, Ronald T. Ingram, Jeffrey M. Brittan
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
Type:
Grant
Filed:
April 19, 2010
Date of Patent:
September 30, 2014
Assignee:
Abbott Cardiovascular Systems Inc.
Inventors:
Syed F.A. Hossainy, Yiwen Tang, Eugene T. Michal, Thierry Glauser, Stephen D. Pacetti, Jessica DesNoyer
Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
September 30, 2014
Assignee:
Warsaw Orthopedic, Inc.
Inventors:
Amira Wohabrebbi, William F. McKay, Vanja Margareta King, Danielle L. Biggs, Katara Shaw, Christopher M. Hobot, Phillip Edward McDonald
Abstract: The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders.
Type:
Application
Filed:
September 7, 2012
Publication date:
September 25, 2014
Applicant:
MOUNT SINAI SCHOOL OF MEDICINE
Inventors:
Edward H. Schuchman, Calogera M. Simonaro
Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
Type:
Application
Filed:
January 20, 2014
Publication date:
September 25, 2014
Inventors:
Timothy A. Ringeisen, William Christopher Wattengel
Abstract: Slow-release excipients which comprise an association of at least one glycogen and at least one alginate with an alkaline-earth metal salt are useful for the preparation of slow-release pharmaceutical formulations.
Type:
Grant
Filed:
December 23, 2008
Date of Patent:
September 23, 2014
Assignee:
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
Abstract: An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.
Type:
Grant
Filed:
July 15, 2013
Date of Patent:
September 23, 2014
Assignees:
Cook Medical Technologies LLC, Cook Biotech Incorporated
Inventors:
David N. Armstrong, Brian L. Bates, Mark W. Bleyer, F. Joseph Obermiller, Umesh H. Patel
Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
Type:
Application
Filed:
June 2, 2014
Publication date:
September 18, 2014
Applicants:
A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS, CORIUM INTERNATIONAL, INC.
Inventors:
Parminder Singh, Adrian Faasse, Gary W. Cleary, Sri Mudumba, Mikhail M. Feldstein, Danir F. Bayramov
Abstract: The invention relates to a preparation for manufacturing an implant, preferably a bone implant, a process for said manufacture and mouldings obtainable therefrom.
Abstract: The invention described herein solves the challenges encountered in providing a safe, efficacious, and satisfactory option for the treatment of opioid addiction. Methods and devices of the invention allow a subject to receive an implantable formulation comprising an opioid receptor ligand, buprenorphine, or a metabolite thereof as a treatment for opioid addiction. The invention preempts several difficulties encountered with conventional methods for the treatment of opioid addiction, and by doing so the invention improves treatment adherence, compliance, patient satisfaction, and overall success rate.
Abstract: The invention described herein solves the challenges encountered in providing a safe, efficacious, and satisfactory option for the treatment of opioid addiction. Methods and devices of the invention allow a subject to receive an implantable formulation comprising an opioid receptor ligand, buprenorphine, or a metabolite thereof as a treatment for opioid addiction. The invention preempts several difficulties encountered with conventional methods for the treatment of opioid addiction, and by doing so the invention improves treatment adherence, compliance, subject satisfaction, and overall success rate.
Abstract: This invention discloses bioerodible delivery compositions for delivering peptide therapeutic agents. The delivery compositions comprise a porous silicon-based carrier material loaded with the therapeutic agent. The delivery compositions may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The delivery compositions may be used for treating or preventing conditions of a patient such as chronic diseases.
Abstract: The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.
Type:
Application
Filed:
April 2, 2014
Publication date:
September 18, 2014
Applicant:
BOARD OF TRUSTEES UNIVERSITY OF ARKANSAS
Inventors:
Cassandra L. Quave, Mark S. Smeltzer, Cesar M. Compadre, Howard Hendrickson
Abstract: Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.
Abstract: The invention provides medical devices comprising high-strength alloys which degrade over time in the body of a human or animal, at controlled degradation rates, without generating emboli and which have enhanced degradation due to the presence of a halogen component. In one embodiment the alloy is formed into a bone fixation device such as an anchor, screw, plate, support or rod. In another embodiment the alloy is formed into a tissue fastening device such as staple. In yet another embodiment, the alloy is formed into a dental implant or a stent.
Abstract: Lung volume reduction by isolating a target lung portion from the rest of the lung with a mass of extracellular matrix (“ECM”) material. The procedure can be performed by locating a tube within the lumen of an airway to be obstructed and depositing an amount of flowable or other ECM in the open space until the lumen is occluded. Optionally, the procedure may be performed by delivering a plug substantially comprised of ECM material into the lumen of an airway to be obstructed. Further optionally, the ECM plug may include a one-way valve to allow air and mucous to escape from the isolated lung portion.
Type:
Application
Filed:
March 14, 2014
Publication date:
September 18, 2014
Inventors:
UMESH H. PATEL, BHAVIN SHAH, MICHELLE CHUTKA
Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
Type:
Grant
Filed:
February 28, 2012
Date of Patent:
September 16, 2014
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services
Inventors:
Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcelo J. A. Amar, Edward B. Neufeld, H. Bryan Brewer, Fairwell Thomas
Abstract: A device for use in combination with a fluid flow having a biologic component and subject to an adverse response to shear stress includes a surface in contact with the flow of the fluid. The surface has a longitudinal direction extending from a leading end toward a trailing end and aligned with a direction of the flow. The surface is susceptible to inducing boundary layer formation within the flow sufficient for a resulting shear stress to induce the response. The surface includes a surface feature sufficient to induce boundary layer tripping in the flow to retard growth of boundary layer formation along the length.
Type:
Grant
Filed:
November 15, 2007
Date of Patent:
September 16, 2014
Assignee:
Georgia Tech Research Corporation
Inventors:
Ari Glezer, Ajit P. Yoganathan, Lakshmi Prasad Dasi
Abstract: A pouch for forming an implantable artificial organ, including a closed shell provided in a semi-pervious membrane. The pouch further includes a sheet contained within the shell, the sheet including projections on the surface thereof for maintaining a space for cells between the sheet and the shell.
Abstract: A medical device has a structure made of one biodegradable and/or bioabsorbable material. A degradation additive is encapsulated by another biodegradable and/or bioabsorbable material forming a nanoparticle or microparticle. The nanoparticle or microparticle is together with the one biodegradable and/or bioabsorbable material of the structure. The other biodegradable and/or bioabsorbable material of the nanoparticle or microparticle has a degradation rate that is faster than a degradation rate of the one biodegradable and/or bioabsorbable material. The structure experiences a period of accelerated degradation upon release of the degradation additive from the nanoparticle or microparticle.
Abstract: An implant material on the basis of a polymer system has a first component and a second component that react with one another when mixed to form a polymer-based solid. The first component is a paste that contains at least one biocompatible polymer powder and a starter component for initiating a polymerization reaction upon mixing, wherein the paste has a carrier liquid, wherein under normal conditions in the carrier liquid the at least one biocompatible polymer powder does not dissolve or significantly swell and the starter component remains stable until mixing with the second component of the polymer system. The second component of the polymer system contains at least one reactive organic liquid or a solution or a suspension of a reactive organic liquid and of a polymer.
Abstract: Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site.
Abstract: One aspect of the present invention relates to a method of occluding a vascular site in a mammal, comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding a vascular site of said mammal, wherein said temporarily occluded vasculature site is kept in a substantially cylindrical shape.
Abstract: In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block.
Type:
Application
Filed:
May 7, 2014
Publication date:
August 28, 2014
Applicant:
BOSTON SCIENTIFIC SCIMED, INC.
Inventors:
Liliana Atanasoska, Jan Weber, Robert W. Warner
Abstract: Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer.
Type:
Application
Filed:
February 28, 2014
Publication date:
August 28, 2014
Applicant:
Purdue Research Foundation
Inventors:
Corey P. Neu, Tyler A. Novak, Garrett Shannon
Abstract: A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal.
Abstract: The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
Type:
Grant
Filed:
June 4, 2009
Date of Patent:
August 26, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Jessica R. DesNoyer, Stephen D. Pacetti, Lothar W. Kleiner, Syed F. A. Hossainy, Yung-Ming Chen, Gordon Stewart, Gina Zhang
Abstract: Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed for treatment of the obstructive sleep apnea event.
Type:
Grant
Filed:
September 22, 2008
Date of Patent:
August 26, 2014
Assignee:
Medtronic Xomed, Inc.
Inventors:
Nikhil D. Bhat, Charisse M. Yung, Anant V. Hegde, George Y. Choi
Abstract: In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.
Type:
Grant
Filed:
July 27, 2007
Date of Patent:
August 26, 2014
Assignee:
Boston Scientific SciMed, Inc.
Inventors:
Liliana Atanasoska, Robert W. Warner, Michael S. Arney, Jan Weber
Abstract: Synthetic composite materials for use, for example, as orthopedic implants are described herein. In one example, a composite material for use as a scaffold includes a thermoplastic polymer forming a porous matrix that has continuous porosity and a plurality of pores. The porosity and the size of the pores are selectively formed during synthesis of the composite material. The example composite material also includes a plurality of a anisometric calcium phosphate particles integrally formed, embedded in, or exposed on a surface of the porous matrix. The calcium phosphate particles provide one or more of reinforcement, bioactivity, or bioresorption.
Type:
Application
Filed:
November 13, 2013
Publication date:
August 21, 2014
Inventors:
Ryan K. Roeder, Gabriel L. Converse, Stephen M. Smith
Abstract: A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an outer surface. There is a second discontinuous polymeric coating containing an antimicrobial agent, which is on top of and covering part of the outer surface of the first coating. The second discontinuous coating has a microstructure.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
August 19, 2014
Assignee:
Ethicon, Inc.
Inventors:
Frank Cichocki, Michael (Jake) Hamilton, Xintian Ming
Abstract: Provided are methods of improving the stability of antiseptic compositions that include elemental iodine and certain hydroxycarboxylic acids, as well as stable, ready to use antiseptic compositions suitable for use in the nose and anterior nares.
Type:
Grant
Filed:
June 29, 2010
Date of Patent:
August 19, 2014
Assignee:
3M Innovative Properties Company
Inventors:
Matthew T. Scholz, Kevin D. Landgrebe, Katie F. Wlaschin
Abstract: In some embodiments the present disclosure provides a method of inactivating a RNA virus of the family retroviridae in a biological sample. Such a method comprises contacting the biological sample with an effective amount of an antiviral composition comprising PD 404,182. In an embodiment of the present disclosure the RNA virus is selected from the group consisting of HIV pseudotyped lentiviruses, primary human immunodeficiency virus-1 isolates (HIV-1), human immunodeficiency virus-2 (HIV-2), and simian immunodeficiency virus (SIV). Further embodiments of the present disclosure pertain to a method of treating a subject infected by a RNA virus of the family retroviridae. Another embodiment of the present invention pertains to a method of preventing transmission of a RNA virus of the family retroviridae in a subject in need thereof.
Type:
Application
Filed:
September 10, 2013
Publication date:
August 14, 2014
Inventors:
Zhilei Chen, Karrupiah Chockalingam, Ana M. Chamoun-Emanuelli, Rudo Simeon, Michael Bobardt, Philippe Gallay
Abstract: Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
Type:
Grant
Filed:
August 14, 2009
Date of Patent:
August 12, 2014
Assignee:
Intersect ENT, Inc.
Inventors:
Patrick A. Arensdorf, Danielle L. Biggs, Rodney Brenneman, David B. Downie, Donald J. Eaton, Thomas R. Tice
Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
Type:
Grant
Filed:
August 11, 2006
Date of Patent:
August 12, 2014
Assignees:
Massachusetts Institute of Technology, Children's Medical Center Corporation
Inventors:
Heejin Lee, Karen Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim
Abstract: Silane-functionalized hydrophobic ?(1?4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic ?(1?4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
Type:
Grant
Filed:
June 2, 2010
Date of Patent:
August 12, 2014
Assignee:
Surmodics, Inc.
Inventors:
Aleksey V. Kurdyumov, Nathan A. Lockwood, Joram Slager, Dale G. Swan, Robert Hergenrother