Ammonia, Amine, Or Derivative Thereof (e.g., Urea, Etc.) Patents (Class 424/54)
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Patent number: 5244652Abstract: High viscosity fluids comprising amphoteric surfactants and Type A gelatin. These compositions can be used in shampoos, dentrifices and cosmetic and pharmaceutical preparations.Type: GrantFiled: March 22, 1991Date of Patent: September 14, 1993Assignee: E. B. Michaels Research Associates, Inc.Inventor: Edwin B. Michaels
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Patent number: 5236699Abstract: An antiplaque mouth rinse conducive to oral hygiene. The mouth rinse composition includes a water-alcohol vehicle having dissolved therein two antibacterial agents that coact to promote the delivery of these agents and their retention on the teeth and soft tissue in the dental region of the oral cavity of the user, thereby inhibiting the formation of plaque. One agent, Triclosan, is water-insoluble and noncationic, a solubilizer therefor being included in the composition. The other agent, cetyl pyridinium chloride (CPC) is soluble in water and alcohol and is cationic. When the combination of Triclosan and CPC is delivered to the dental region, it is adsorbed and retained thereby to afford enhanced antibacterial activity.Type: GrantFiled: June 22, 1992Date of Patent: August 17, 1993Inventor: Barry M. Libin
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Patent number: 5221683Abstract: The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: January 17, 1992Date of Patent: June 22, 1993Assignees: The Rockefeller University, Alteon Inc.Inventors: Peter C. Ulrich, Anthony Cerami, Dilip R. Wagle
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Patent number: 5208009Abstract: An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a water-soluble or water swellable polymer having a molecular weight of about 1,000-2,000,000, such as a linear copolymer of maleic anhydride and vinyl methyl ether or a polyvinyl phosphonate. The polymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials. Also within the invention is a process for applying such compositions to the teeth, and it has been shown by both in vitro and in vivo testing that significant repeatable improvements in anticalculus effects are obtained by such processes, compared to control processes in which either of the active components mentioned is employed alone in the described oral compositions.Type: GrantFiled: November 25, 1991Date of Patent: May 4, 1993Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, John J. Afflito, Marilou T. Joziak
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Patent number: 5202113Abstract: A purified, characterized surface protein from Bacteroides loeschei is an adhesin which is useful in inhibiting plaque formation. The adhesin is also useful in a diagnostic assay for gingivitis, a diagnostic indicator for changes in the surface components of certain human tissues, and as a binding agent to purify polysaccharides.Type: GrantFiled: April 30, 1990Date of Patent: April 13, 1993Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Jack London
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Patent number: 5192533Abstract: A method and composition for controlling tartar and plaque formation in the mouth is reported which has a relatively low irritation to the mucosae. The oral composition includes (1) a hypophosphite-containing cotelomer in an amount effective for controlling tartar; and (2) an antibacterial agent selected from the group consisting of diphenyl ethers, bis-biguanides, halogenated carbanilides and salicylamides.Type: GrantFiled: March 25, 1992Date of Patent: March 9, 1993Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.Inventors: David L. Elliott, Esther Patrick
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Patent number: 5189987Abstract: The invention provides a liquid composition for deodorizing animal wastes by contact therewith. The composition comprises an aqueous dispersion which contains an ammonia-controlling-effective amount of pine oil and a dispersion aid. The dispersion aid is selected from anionic, nonionic, cationic, amphoteric surfactants, and mixtures of these surfactants.Type: GrantFiled: May 20, 1991Date of Patent: March 2, 1993Assignee: The Clorox CompanyInventors: Anna G. Stanislowski, J. Bruce England
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Patent number: 5190743Abstract: Plaque disclosing compositions containing a cobalamin compound such as Vitamin B.sub.12 as the disclosant and the process of treating the oral cavity therewith.Type: GrantFiled: October 10, 1991Date of Patent: March 2, 1993Assignee: Colgate-Palmolive CompanyInventors: Alexander J. Simone, Thomas G. Polefka
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Patent number: 5188822Abstract: Oral composition containing an oil-in-water emulsion, wherein the oil phase of the emulsion includes an aminoalkyl silicone and a lipophilic compound and the aqueous phase includes an emulsifier. The lipophilic compound is soluble in the aminoalkyl silicone. Preferably, a lipophilic antimicrobial agent or a lipophilic flavorant is employed. The aminoalkyl silicone forms a substantive film on the teeth surface and the lipophilic compound is deposited, along with the aminoalkyl silicone, on the teeth surface. Thus, the enhanced deposition of the lipophilic compound is attained. The pH of the compositions is preferably at least 7.0. The compositions are preferably applied by brushing.Type: GrantFiled: August 7, 1991Date of Patent: February 23, 1993Assignee: Chesebrough-Pond's USA Co., Division of Conopco Inc.Inventors: John P. Viccaro, John S. Bajor, Alla Tartakovsky
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Patent number: 5182101Abstract: Toothpastes which contain 10-60 wt. % of polishing agents, 2-20 wt. % of humectants, 0.5-5 wt. % of water-soluble consistency regulators and 0.05-0.5 wt. % of antimicrobial biguanides, as well as 1-5 wt. % of other additives from the group of surface-active substances, aromatic oils, and sweeteners, have a particularly high biguanide availability if the polishing agent consists mainly of calcium carbonate, the consistency regulators are non-ionic polysaccharide derivatives and the surface-active substances are cationic surfactants with a linear alkyl group containing 12-18 carbon atoms and one or two tertiary amino groups or quaternary ammonium groups. Optionally a non-ionogenic solubilizer for the aromatic oil may also be present in the toothpastes.Type: GrantFiled: February 20, 1992Date of Patent: January 26, 1993Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Peter Wuelknitz, Rudolf Lehmann, Hans-Juergen Klueppel
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Patent number: 5180577Abstract: An oral composition is provided and a method for making the same. The composition comprises a cationic antibacterial agent, an anionic active ingredient and, as a stabilizing agent, a stabilizing quantity of a betaine surfactant.Type: GrantFiled: October 9, 1990Date of Patent: January 19, 1993Assignee: Colgate-PalmoliveInventors: Thomas G. Polefka, Deborah S. Sanai, Brian S. Jannone
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Patent number: 5176901Abstract: Dentifrices containing cationic antibacterial agents are disclosed herein.Type: GrantFiled: April 10, 1991Date of Patent: January 5, 1993Assignee: SmithKline Beecham CorporationInventors: Andrew R. Gallopo, Nader I. Ibrahim, Salvatore Mazzanobile
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Patent number: 5175192Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylatin. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: April 3, 1990Date of Patent: December 29, 1992Assignee: The Rockefeller UniversityInventors: Peter C. Ulrich, Anthony Cerami
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Patent number: 5174989Abstract: An oral composition comprising (i) at least one fluoride compound and (ii) at least one 5- or 6-membered, substituted heterocyclic compound which contains 1 to 3 nitrogen atoms as ring hetero atoms, which may contain an oxygen or sulfur atom as a ring hetero atom, and which may be condensed with one or two 6-membered carbocyclic or heterocyclic rings, or a salt thereof. This oral composition is very effective for preventing carries of the teeth.Type: GrantFiled: August 21, 1990Date of Patent: December 29, 1992Assignee: Shiseido Company Ltd.Inventors: Kumiko Tanaka, Seishiro Fujii
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Patent number: 5171564Abstract: An aqueous abrasive oral composition which exhibits heightened and rapid whitening of teeth is obtained when using a combination of a dicalcium phosphate compound, a metal ion free peroxide, a chelating agent and a thickening agent.Type: GrantFiled: September 13, 1991Date of Patent: December 15, 1992Assignee: Colgate-PalmoliveInventors: Salim A. Nathoo, Mary B. Chmielewski, Sahar Fakhry-Smith
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Patent number: 5167952Abstract: This invention relates to novel oral compositions for dental hygiene in the form of a dental rinse and methods of application, effective in the prevention of the formation and buildup of dental plaque on the teeth, causing dental Caries, Calculus and Periodontal disease Gingivitis, and Periodontitis, by stimulating and increasing the rate of Prostaglandin synthesis in the mouth to levels many times higher than that occurring naturally, thereby enhancing and reconstituting the person's Immune System Response and ability to resist bacterial infection so as to effectively control, combat and destroy the natural bacteria in the mouth that cause plaque.Type: GrantFiled: October 4, 1991Date of Patent: December 1, 1992Inventor: John E. McHugh
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Patent number: 5160737Abstract: The invention relates to a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: March 28, 1990Date of Patent: November 3, 1992Assignees: Perio Products Ltd., Yissum Research Development CompanyInventors: Michael Friedman, Amnon Sintov
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Patent number: 5158763Abstract: An oral composition is provided which comprises an oral vehicle and contains at least one antibacterial antiplaque agent which can stain or discolor dental surfaces. Provided in such oral composition is an effective stain-inhibiting amount of an antistaining additive, such additive being azacycloalkane disphosphonic acid or an orally acceptable salt thereof.Type: GrantFiled: October 9, 1990Date of Patent: October 27, 1992Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, Thomas G. Polefka
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Patent number: 5154915Abstract: Dentifrices, including toothpastes and mouthwashes, are provided which include aminoalkyl silicones and sarcosine surfactants. In the mouth, the aminoalkyl silicones form a lasting hydrophobic film on the teeth for prevention of cavities and stain. Antimicrobial compounds such as chlorhexidine may be included.Type: GrantFiled: April 23, 1990Date of Patent: October 13, 1992Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.Inventors: Thomas R. Weber, Nancy H. Krysiak, John P. Viccaro, Samuel Lin, Todd Domke
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Patent number: 5147632Abstract: Compositions having improved anti-plaque activity comprise a synergistic combination of a) a morpholinoamino alcohol, such as 3-(4-propylheptyl)-4-(2-hydroxyethyl) morpholine, and b) a chelating agent such as ethylenediaminetetraacetic acid.Type: GrantFiled: October 31, 1990Date of Patent: September 15, 1992Assignee: Warner-Lambert CompanyInventors: Pauline H. Pan, Linda D. Sturdivant
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Patent number: 5145664Abstract: There is described an improved alcohol free mouthwash comprising sodium chloride, sodium bicarbonate and water.Type: GrantFiled: June 25, 1991Date of Patent: September 8, 1992Assignee: Thompson McKay Pharmaceuticals, Ltd.Inventor: William J. Thompson
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Patent number: 5139768Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: February 28, 1991Date of Patent: August 18, 1992Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Michael Friedman
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Patent number: 5130337Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel amidrazones and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: May 7, 1991Date of Patent: July 14, 1992Assignees: The Rockefeller University, Alteon Inc.Inventors: Peter C. Ulrich, Anthony Cerami
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Patent number: 5130324Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain 2-alkylidene aminoguanidines and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.Type: GrantFiled: May 7, 1991Date of Patent: July 14, 1992Assignees: The Rockefeller University, Alteon Inc.Inventors: Peter C. Ulrich, Anthony Cerami
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Patent number: 5128122Abstract: The present invention relates to methods and agents for preventing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Both oral and parenteral administration ft the agents are disclosed. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rinses and toothpastes, and include compounds capable of reacting with the carbonyl moiety of the early glycosylation product resulting from the initial reaction of a target protein in the nonenzymatic browning reaction. Preferred agents are those having an active nitrogen-containing substituent, as well as amino acids, their esters and amides. These preparations may further include known anti-plaque agents such as chlorhexidine.Type: GrantFiled: October 26, 1990Date of Patent: July 7, 1992Assignee: The Rockefeller UniversityInventors: Anthony Cerami, Michael A. Yamin
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Patent number: 5120460Abstract: A dental cleaner material comprises as a main component an aqueous solution containing 0.1 to 2.0% by weight of ethylenediaminetetraacetic acid or at least one of its alkali metal salts. The cleaner material is gelled by the addition of a carboxyvinyl polymer, carboxymethylcellulose or sodium carboxymethylcellulose as a raiser in viscosity showing thixotropy, further contains 0.01 to 0.3% by weight fo a p-hydroxybenzoic acid ester as an antibacterial agent, and is regulated to pH of 7.0.+-.0.5.Type: GrantFiled: March 29, 1990Date of Patent: June 9, 1992Assignees: G-C Dental Industrial Corp., Yasuhiro AsaiInventors: Yasuhiro Asai, Kiyoko Nakamura, Masayuki Takahashi
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Patent number: 5108735Abstract: An oral composition comprising mutanase and, as surfactants, a N-acyl sarcosinate or a N-acyl-L-glutamate together with one or more of nonionic surfactants selected from the group consisting of polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene lanolin derivative, polyoxyethylene nonyl phenyl formaldehyde condensate, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil and polyethylene glycol fatty acid ester.Type: GrantFiled: May 3, 1990Date of Patent: April 28, 1992Assignee: Sunstar Kabushiki KaishaInventors: Hidehiko Ohtsuki, Sayuri Tanii, Satoko Ozawa
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Patent number: 5100650Abstract: The invention provides an anti-bacterial oral composition such as mouthrinse which includes a bis-biguanido hexane compound such as chlorhexidine and compounds thereof, certain non-ionic surfactants which are poly(oxyethylene)-poly(oxypropylene) block copolymers having an HLB of between 10 and 30 or an ethoxylated hydrogenated caster oil containing from about 10 to 200 moles of added ethylene oxide and sorbitol in high concentrations. The oral composition is found to increase the activity of the bis-biguanido compound from 25% to 150%.Type: GrantFiled: June 30, 1987Date of Patent: March 31, 1992Assignee: Warner-Lambert CompanyInventors: Edward J. Carlin, Anil K. Talwar, Linda T. Principe, Steven S. Dills
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Patent number: 5100653Abstract: A pharmaceutical product for topical treatment of diseases and infections of parodental areas in which trometamol in a concentration of less than 3% is combined with sulfur and allantoin to obtain the desired acid neutralizing effects of trometamol without the undesired side effects.Type: GrantFiled: February 8, 1991Date of Patent: March 31, 1992Inventor: Giovanni Campo
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Patent number: 5100649Abstract: A plaque-inhibiting and/or caries-inhibiting, aqueous composition for use in the oral cavity, such as a toothpaste or mouthwash composition, comprising a water carrier and a therapeutic, effective amount of a perfluoroalkyl surfactant having a perfluoroalkyl group and containing a cationic group, such as a cationic perfluoroalkyl thio ether quaternary tri-methyl ammonium compound or an amphoteric perfluoroalkyl anionic-cationic compound.Type: GrantFiled: November 15, 1990Date of Patent: March 31, 1992Assignee: Forsyth Dental Infirmary for ChildrenInventors: Vera B. Caslavsky, Poul Gron
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Patent number: 5098691Abstract: Plaque disclosing compositions containing a cobalamin compound such as Vitamin B.sub.12 as the disclosant and the process of treating the oral cavity therewith.Type: GrantFiled: May 6, 1991Date of Patent: March 24, 1992Assignee: Colgate-Palmolive CompanyInventors: Alexander J. Simone, Thomas G. Polefka
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Patent number: 5096700Abstract: The subject invention involves halogenated amino acid derivatives useful as antimicrobial agents having the structure: ##STR1## wherein --R is hydrogen or 2-aminoethyl; --R' is hydroxy, alkoxy, aryloxy, or an amino acid residue bonded at the amino nitrogen; --R" is hydrogen or an amino acid residue bonded at the carbonyl carbon; --X is halogen; and --Y is hydrogen or halogen.Type: GrantFiled: September 28, 1990Date of Patent: March 17, 1992Assignee: The Procter & Gamble CompanyInventors: William L. Seibel, Joseph H. Gardner
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Patent number: 5096699Abstract: An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a polymeric polycarboxylate, which is preferably a linear copolymer of maleic anhydride and vinyl methyl ether of a molecular weight in the range of about 5,000-2,000,000, preferably about 30,000-1,500,000. The copolymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials.Type: GrantFiled: December 20, 1990Date of Patent: March 17, 1992Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, John J. Afflitto, Marilou T. Joziak
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Patent number: 5096703Abstract: The present invention relates to methods and agents for preventing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Both oral and parenteral administration of the agents are disclosed. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rinses and toothpastes, and include compounds capable of reacting with the carbonyl moiety of the early glycosylation product resulting from the initial reaction of a target protein in the nonenzymatic browning reaction. Preferred agents are those having an active nitrogen-containing substituent, as well as amino acids, their esters and amides. These preparations may further include known anti-plaque agents such as chlorhexidine.Type: GrantFiled: October 30, 1990Date of Patent: March 17, 1992Assignee: The Rockefeller UniversityInventors: Anthony Cerami, Michael A. Yamin
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Patent number: 5082653Abstract: Compositions having improved anti-plaque and anti-gingivitis activity comprises a synergistic combination of a) a morpholinoamino alcohol, such as 3-(4-propylheptyl)-4-(2-hydroxyethyl)morpholine and b) and antibiotic, such as the aminoglycosides, amphenicols, ansamycins, carbapenems, cephalosporins, cephamycins, monobactams, oxacephems, penicillins, lincosamides, macrolides, polypeptides and tetracyclines.Type: GrantFiled: October 31, 1990Date of Patent: January 21, 1992Assignee: Warner-Lambert CompanyInventors: Pauline E. Pan, Linda D. Sturdivant
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Patent number: 5080887Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncatationic antibacterial agent such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (Triclosan).Type: GrantFiled: August 8, 1991Date of Patent: January 14, 1992Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, Nuran Nabi, Brian S. Jannone
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Patent number: 5078988Abstract: Dentifrices including modified amino alkyl silicones are provided. The aminoalkyl silicones are modified with epoxides to alkylate the nitrogen atoms and decrease their reactivity to flavors and other aldehydes present in the dentifrice. The modified silicones form a hydrophobic layer on the teeth for prevention of caries and stain.Type: GrantFiled: November 28, 1988Date of Patent: January 7, 1992Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc.Inventors: Samuel Lin, Colleen Parriott, John P. Viccaro, Todd Domke
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Patent number: 5079288Abstract: Oral hygiene compositions effective for preventing the adherent deposition of cariogenic bacteria on teeth comprise as active constituents polymers having defined repeating units comprising hydrocarbyl groups with pendant carboxyl and pendant polyalkylene oxide groups in defined ratio. The polymers themselves, their prepartion, and a process for treating teeth with the compositions are also claimed.Type: GrantFiled: March 19, 1990Date of Patent: January 7, 1992Assignee: Imperial Chemical Industries PLCInventors: Martyn Humphries, Jozef Nemcek, Joseph F. Jaworzyn, John B. Cantwell, John J. Gerrard
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Patent number: 5073368Abstract: Mouthrinses containing sanguinaria of improved anti microbial efficacy and stability are attained by including in the mouthrinse a surfactant combination of an amidobetaine and poly(oxyethylene)-poly(oxypropylene) block copolymer.Type: GrantFiled: May 15, 1991Date of Patent: December 17, 1991Assignee: Colgate-Palmolive CompanyInventor: Malathy Subramanian
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Patent number: 5066483Abstract: Mouthrinses containing sanguinarine of superior efficacy and increased uptake into dental plaque are attained by the development of stable mouthrinses adjusted to a pH in the range of 4.0 to 5.6, preferably about 4.5. The compositions may contain a zinc salt as an optional ingredient. Various types of buffer systems are described.Type: GrantFiled: September 17, 1990Date of Patent: November 19, 1991Assignee: Vipont Pharmaceutical, Inc.Inventors: Ronald J. Harkrader, Richard R. Jones, Kenneth S. Peterson
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Patent number: 5063046Abstract: A dentifrice composition contains, as an anti-caries agent, at least one water-soluble polycationic polymer, containing units which contain at least one quaternized nitrogen which is part of the macrochain, and in which at least 5% of the cationic charges are balanced by fluoride anions; and use of such polycationic polymer fluorides as anti-caries agents.Type: GrantFiled: May 17, 1990Date of Patent: November 5, 1991Assignee: L'OrealInventor: Jean-Francois Grollier
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Patent number: 5059416Abstract: A new delivery system for zinc compounds and the process for its preparation is disclosed, which has use in a variety of products including comestibles such as chewing gum compositions, confections, pharmaceuticals, food products such as vitamin preparations, dentifrice compositions and throat lozenges. More particularly, this invention relates to a process for preparing a zinc compound delivery system comprised of a zinc core material coated with a first hydrophilic coating comprising a hydrocolloid material and a second hydrophobic coating selected from the group consisting of fats, waxes and mixtures thereof. The delivery system provides enhanced masking of the bitter flavor characteristic of zinc compounds, as well as reduced grittiness with retained stability at the elevated temperatures of product formulation.Type: GrantFiled: June 26, 1989Date of Patent: October 22, 1991Assignee: Warner-Lambert CompanyInventors: Subraman R. Cherukuri, Tommy L. Chau
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Patent number: 5051401Abstract: A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure:poly (X).sub.m (Y).sub.nwhereeach X independently is aspartate, glutamate, glutamine, asparagine, or anionic derivatives of these amino acids, or phosphoserine,each Y independently is a phosphorylated amino acid such as phosphoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, or mixtures of these residues,m is 2 to 150,n is 1 to 3, andn+m is .gtoreq.5, andsalts of these peptides.Type: GrantFiled: April 7, 1989Date of Patent: September 24, 1991Assignee: University of South AlabamaInventor: C. Steven Sikes
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Patent number: 5045306Abstract: N-alkylamide of DL and L(-)-carnitine having general formula (I) ##STR1## wherein: x.sup.- is OH.sup.- or the anion of a pharmacologically acceptable acid (preferably Cl.sup.-`), andR is a straight C.sub.10 -C.sub.16 alkyl radicalare prepared via transamination by reacting DL or L(-)-carnitinamide halogenide with an amine of formula NH.sub.2 R wherein R has the above-identified meaning in an acid environment (e.g. H.sub.3 PO.sub.4) in the presence of a high-boiling solvent (e.g. ethylene glycol).N-alkylamides (I) are endowed with potent antibacterial activity and are suitable for preparing pharmaceutical and cosmetic compositions.Type: GrantFiled: November 4, 1988Date of Patent: September 3, 1991Assignee: Avantgarde S.p.A.Inventors: Paolo Cavazza, Giulio Fiorentini
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Patent number: 5043154Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (Triclosan).Type: GrantFiled: May 1, 1989Date of Patent: August 27, 1991Assignee: Colgate-Palmolive Co.Inventors: Abdul Gaffar, Nuran Nabi, Brian S. Jannone
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Patent number: 5041280Abstract: A toothpaste composition having the following ingredients, by weight:______________________________________ Dicalcium Phosphate dihydrate: From 1.0% to 50% Calcium Carbonate From 1.0% to 50% Sodium Bicarbonate From 1.0% to 50% Magnesium Carbonate From 1.0% to 25% Sorbitol 70% From 1.0% to 50% Corn Starch From 0.5% to 10% Cellulose Gum From 0.5% to 5.0% Calcium Peroxide From 0.5% to 5% Lathanol LAL (Sodium Lauryl From 0.1% to 5% Sulfoacetate) Aluminum Hydroxide From 0.01 to 1% Saccharinate (Sodium Salt) From 0.05% to 2% Flavoring material From 0.05% to 2% Alkylparaben From 0.05% to 1.0% Sodium monofluorophosphate From 0.70% to 0.80% Titanium Dioxide From 0.Type: GrantFiled: October 1, 1987Date of Patent: August 20, 1991Assignee: Epilady USA, Inc.Inventor: Irwin E. Smigel
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Patent number: 5037637Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-tricholoro-2.sup.1 -hydroxydiphenyl ether (Triclosan).Type: GrantFiled: December 8, 1989Date of Patent: August 6, 1991Assignee: Colgate-Palmolive CompanyInventors: Abaul Gaffar, Nuran Nabi, Brian S. Jannone
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Patent number: 5037634Abstract: An oral composition is provided having exceptional anti-plaque action, the composition comprising a bicarbonate salt, a copper compound and a complexing agent to stabilize the copper.Type: GrantFiled: August 16, 1990Date of Patent: August 6, 1991Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc.Inventors: David R. Williams, Alexander G. Ziemkiewicz
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Patent number: 5035881Abstract: A dentifrice composition containing a bactericide selected from the group consisting of biguanido bactericides and N-alkyldiaminoethylglycine, a polyoxyethylenepolyoxypropylene block copolymer surfactant and a N-higher acylamino acid or its salt is disclosed. The dentifrice composition maintains bactericidal activities of the bactericide added.Type: GrantFiled: April 16, 1990Date of Patent: July 30, 1991Assignee: Sunstar Kabushiki KaishaInventors: Shigeki Mori, Chiho Makino
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Patent number: 5035880Abstract: A dentifrice composition stably containing cetylpyridinium chloride and having improved shape retention at a low temperature in the form of an aqueous gel is disclosed. The composition comprises 15 to 80% by weight of a polyoxyethylene-polyoxypropylene block copolymer surfactant based on the total weight of the composition, 0.001 to 5% by weight of cetylpyridinium chloride based on the total weight of the composition, and polyethylene glycol having an average molecular weight of 2,000 to 20,000 in a proportion of 1/200 to 1/4 based on the weight of the polyoxyethylene-polyoxypropylene block copolymer.Type: GrantFiled: August 6, 1990Date of Patent: July 30, 1991Assignee: Sunstar Kabushiki KaishaInventors: Shigeki Mori, Naomi Yokosuka