Ammonia, Amine, Or Derivative Thereof (e.g., Urea, Etc.) Patents (Class 424/54)
-
Patent number: 6248309Abstract: Gum compositions containing effective amounts of antimicrobial agents that are released to the oral cavity during chewing. In specific embodiments, the antimicrobial agents are released from the gum at different rates and times.Type: GrantFiled: August 19, 1999Date of Patent: June 19, 2001Assignee: Optiva CorporationInventors: Lokanathan M. Iyer, Dawn E. Barkans, Brian D. Hench
-
Patent number: 6207138Abstract: A method and composition for remineralizing teeth wherein the composition contains a mixture of a casein glycomacropeptide and xylitol.Type: GrantFiled: August 11, 1999Date of Patent: March 27, 2001Assignee: Colgate-Palmolive CompanyInventors: Yun Po Zhang, Abdul Gaffar
-
Patent number: 6207137Abstract: An orally absorbable improved dental formulation is provided. The dental formulation includes a base to which an active component is added. The active component comprises, based on the overall weight thereof, Vitamin C in an amount between about 10 and 25 weight percent, and Co-enzyme Q-10 (or ubiquinone), in an amount between 10 and 25 weight percent, are added.Type: GrantFiled: December 11, 1998Date of Patent: March 27, 2001Assignee: C.S. Bioscience, Inc.Inventors: David J. Shuch, Gerald P Curotola
-
Patent number: 6200551Abstract: A treatment for xerostomia, employing a composition having the active ingredient of carbamide peroxide. The carbamide peroxide compound contains urea and hydrogen peroxide. The hydrogen peroxide remains stable until the carbamide peroxide is applied to the mouth and contacts the water inherent therein. On contact, the hydrogen peroxide is freed from the urea, allowing the hydrogen peroxide to react within the mouth. The resulting chemical and mechanical reaction stimulates saliva within the mouth and thereby relieves the symptoms of xerostomia.Type: GrantFiled: January 27, 2000Date of Patent: March 13, 2001Inventor: Susan Ann Morgan
-
Patent number: 6190642Abstract: Irrigants to be used with vibratory scaling apparatus and lavage are provided. The irrigants of the invention are characterized in that they contain medicaments for the treatment of conditions in the mouth and have a viscosity and deliquescence adapted to substantially optimize the efficiency of the apparatus. The irrigants are formulated so that they have minimal stickiness on drying, minimal foaming and do not gum-up the apparatus in which they are used. Also provided is a method for treating dental diseases comprising applying the irrigants of the invention through a vibratory scaring apparatus to substantially optimize the efficiency of said apparatus and to substantially optimize destruction and removal of infectious bacteria using said apparatus and the removal or inactivation of endotoxins derived from bacteria or the host.Type: GrantFiled: October 18, 1994Date of Patent: February 20, 2001Assignee: Dentsply Research & Development Corp.Inventors: Emery W. Dougherty, John B. Heyde
-
Patent number: 6187296Abstract: An agent, &agr;-difluoromethyl lysine (DEML) or &agr;-monofluoromethyl lysine (MFML), which inhibits activity of lysine decarboxylases produced by bacteria associated with periodontal tissues. Inhibition of the activity of such lysine decarboxylases can prophylactically and therapeutically treat periodontal diseases such as gingivitis and periodontitis. The agent may be incorporated into toothpastes, mouthwashes, irrigation solutions, tablets, periodontal treatment packs, or an adhesive paste or film coatings for applying to the teeth.Type: GrantFiled: February 28, 2000Date of Patent: February 13, 2001Assignee: The Board of Regents of the University of OklahomaInventor: Martin Levine
-
Patent number: 6169083Abstract: The invention relates to agents for treating and preventing stomatitis, comprising an L-carnosine zinc salt or L-carnosine-zinc complex, or such a compound and sodium alginate. The agents are excellent in therapeutic and preventive effects on stomatitis and particularly exhibit marked effects on stomatitis caused by chemotherapy or radiotherapy for cancer.Type: GrantFiled: December 31, 1998Date of Patent: January 2, 2001Assignees: Zeria Pharmaceutical Co., Ltd., Hamari Chemicals Co., Ltd.Inventors: Masaaki Hirano, Shirou Katayama
-
Patent number: 6143281Abstract: The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavor which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.Type: GrantFiled: May 26, 1999Date of Patent: November 7, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Stephan Edward Alexander, Geoffrey Royston Doel, Peter John Edwards
-
Patent number: 6117417Abstract: Mouthwash compositions are described comprising cetylpyridinium chloride and amidobetaine amphoteric surfactants of formula (I): RC(O)NH(CH.sub.2).sub.a N.sup.+ (R.sup.1)(R.sup.2)(CH.sub.2).sub.b CO.sub.2.sup.-, wherein R is C.sub.10-20 alkyl; R.sup.1 and R.sup.2 are independently C.sub.1-4 alkyl; a is an integer from 1 to 4; and b is an integer from 1 to 4.Type: GrantFiled: November 25, 1998Date of Patent: September 12, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Mark Andrew Wicks, Peter Scott McConville, Paula Walsh
-
Patent number: 6117415Abstract: Toothpaste incorporating chlorhexidine bigluconate for improved adhesive onto the surface of the teeth. A second embodiment discusses the use of triclosan and in combination with sodium monofluorphosphate for use in the toothpaste.Type: GrantFiled: June 17, 1999Date of Patent: September 12, 2000Assignee: AlphaRx Inc.Inventor: Joseph Schwarz
-
Patent number: 6113887Abstract: There is disclosed a toothpaste composition containing: (1) a water-soluble bactericide selected from the group consisting of pyridinium compounds, quaternary ammonium compounds and biguanide compounds in an amount of 0.001% to 5.0% by weight, based on the total weight of the composition; (2) a cationically-modified hydroxyethylcellulose having an average molecular weight of 1,000,000 or higher in the hydroxyethylcellulose portion thereof and having a cationization degree of 0.05 to 0.5 mol/glucose in an amount of 0.5% to 5.0% by weight, based on the total weight of the composition; (3) a surfactant selected from the group consisting of polyoxyethylene polyoxypropylene block copolymers and alkylolamide compounds in an amount of 0.5% to 13% by weight, based on the total weight of the composition; and (4) a polishing agent of the non-silica type in an amount of 5% to 50% by weight, based on the total weight of the composition.Type: GrantFiled: December 21, 1993Date of Patent: September 5, 2000Assignee: Sunstar Kabushiki KaishaInventors: Shigeki Mori, Takako Nakajima
-
Patent number: 6103220Abstract: An agent, .alpha.-difluoromethyl lysine (DFML) or .alpha.-monofluoromethyl lysine (MFML), inhibits lysine decarboxylases produced by bacteria associated with periodontal tissues. Inhibition of such lysine decarboxylases can prophylactically and therapeutically treat periodontal diseases such as gingivitis and periodontitis. The agent may be incorporated into toothpastes, mouthwashes, irrigation solutions, tablets, periodontal treatment packs, or an adhesive paste or film coatings for applying to the teeth.Type: GrantFiled: January 22, 1999Date of Patent: August 15, 2000Inventor: Martin Levine
-
Patent number: 6096328Abstract: A system for delivering an oral care substance to the oral surface, the delivery system comprising a strip of flexible material having a sufficient flexibility to form to the contours of the oral surface. The strip of material is readily conformable to oral surfaces without permanent deformation when the delivery system is placed there against. The oral care substance is applied to the strip of material such that when the delivery system is placed on the oral surface the active contacts the surface. The oral care substance also provides adhesive attachment between the strip of material and the oral surface so as to hold the delivery system in place for a sufficient amount of time to allow the active to act upon the oral surface.Type: GrantFiled: November 19, 1998Date of Patent: August 1, 2000Assignee: The Procter & Gamble CompanyInventors: Paul Albert Sagel, Robert Stanley Dirksing, Frederick James Rohman, Satyanarayana Majeti, Elizabeth Ann Reno
-
Patent number: 6086856Abstract: Oral hygiene formulations comprising foaming surfactants are dispensed in the form of foams by means of an air-driven propellantless dispenser. The formulations comprise mouthwashes, rinses and dentifrices containing one or more antimicrobial anti-plaque and anti-cariogenic agents.Type: GrantFiled: September 19, 1995Date of Patent: July 11, 2000Assignee: OralCare Systems, Inc.Inventors: Albert Saferstein, Gary Gerard Fores
-
Patent number: 6084005Abstract: An antimicrobial caries-detecting composition, which comprises(i) water, a water-miscible solvent or a combination thereof, (ii) a dye capable of staining the caries-infected portions of teeth, and (iii) at least one antimicrobial agent.Type: GrantFiled: February 24, 1998Date of Patent: July 4, 2000Assignee: Kuraray Co., Ltd.Inventors: Kyoko Fukunishi, Kenichi Hino
-
Patent number: 6074662Abstract: This invention relates to chewable objects for animals which contain, as a dentally therapeutic ingredient, one or more cationic substances. The inventive therapeutic animal chews are of sufficient durability to allow for a chewing cycle long enough for the release of the aforementioned cationic substances into saliva. Furthermore, the inventive animal chews may contain an effective amount of a counter-ionic compound, such as an alkali metal salt, to allow for rapid solubilization of said cationic antimicrobial substance into the saliva of an animal chewing thereupon, especially when delivered or carried on a carrier having a negatively charged surface.Type: GrantFiled: August 15, 1996Date of Patent: June 13, 2000Inventor: Robert E. Montgomery
-
Patent number: 6056944Abstract: Polar lipid composition of plant origin for conveying an active agent and/or making it penetrate into a target cell, the composition being characterized in that it is comprised of an injectable, intra-articular, topical or ingestable aqueous emulsion of a polar lipid mixture rich in phospholipids, in glycolipids and in ceramides, having a composition which is substantially similar to that of the polar lipids constituents of lipid cytomembranes of cells and obtained from a plant compound such as cereal flour or an extract such as bran or lipids extracted from cereals by means of chlorinated solvants.Type: GrantFiled: June 8, 1998Date of Patent: May 2, 2000Assignee: SynthelaboInventor: Claudine Finidori
-
Patent number: 6024891Abstract: This invention relates to a method of improving the stability of a bleach and lipophile composition comprising an inorganic persalt bleaching agent and a lipophile selected from the group consisting of flavorants, perfumes, coolants, antimicrobial agents, and mixtures thereof, by inclusion of an aminoalkylsilicone, having an aminoalkylsiloxane content of from about 0.1% to 2% on a repeating unit basis.Type: GrantFiled: June 23, 1997Date of Patent: February 15, 2000Assignee: The Procter & Gamble CompanyInventor: Iain Allan Hughes
-
Patent number: 6011067Abstract: The present invention deals with the combination of several synergistic antioxidants including enzymatic co-factors as adjuncts to therapy of desquamating inflammatory disorders, such as psoriasis. These topical compositions are aimed to neutralize free radical species generated by such inflammatory conditions which are responsible for certain clinical signs and symptoms. As such, damage to skin causing destruction of elastin and collagen tissues is reduced. The present synergistic antioxidants may be combined with anti-inflammatories, including corticosteroids, anti-microbials, including zinc pyrithione, and other preparations useful in the therapy of desquamating disorders as psoriasis, seborrhoeic dermatitis and related skin and scalp conditions.Type: GrantFiled: June 11, 1999Date of Patent: January 4, 2000Assignee: Thione International, Inc.Inventor: Theodore Hersh
-
Patent number: 6008171Abstract: A denture cleansing composition comprising an inorganic persalt bleaching agent, an effervescence generator and an aminoalkysilicone. The composition provides improved antiplaque, cleasing and antibacterial activity together with excellent physical and in-use performance characteristics.Type: GrantFiled: August 21, 1997Date of Patent: December 28, 1999Assignee: The Procter & Gamble CompanyInventors: Iain Allan Hughes, Elizabeth Mary Ryan, Christopher David White
-
Patent number: 6007795Abstract: A method for inhibiting bacteria in the mouth of a patient which includes placing a particle containing a degradable material and an anti-microbial agent in the mouth of the patient. The exterior of the particle is water-stable. The particles may be coated on dental floss or the bristles of a toothbrush, or incorporated into an oral rinse. Once placed in the mouth, the degradable material degrades to cause release of the anti-microbial agent, resulting in the inhibition of bacteria in the mouth.Type: GrantFiled: January 16, 1997Date of Patent: December 28, 1999Assignee: Gillette Canada Inc.Inventors: Thomas Craig Masterman, Jean L. Spencer
-
Patent number: 5998390Abstract: Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.Type: GrantFiled: September 28, 1998Date of Patent: December 7, 1999Assignee: The Research Foundation of State University of New YorkInventors: Nungavarm S. Ramamurthy, Lorne M. Golub, Timo A. Sorsa, Olli P. Teronen, Tuula A. Salo
-
Patent number: 5994383Abstract: Antimicrobial compositions and methods for preparing and using same are provided. The antimicrobial compositions are surfactant-based and contain certain benzalkonium chloride homologs. The compositions are useful in treating infections in animals and humans, and can be applied to areas including the skin, nails, and mouth.Type: GrantFiled: November 18, 1997Date of Patent: November 30, 1999Assignee: Woodward Laboratories, Inc.Inventors: David L. Dyer, Kenneth B. Gerenraich
-
Patent number: 5980868Abstract: The present invention discloses applicators containing cationic surface active agents, hydrophobic barrier-forming materials and antimicrobial compounds which form, upon application to dental surfaces, a protective and bacteria-inhibiting film.Type: GrantFiled: March 22, 1996Date of Patent: November 9, 1999Inventors: Andrew M. Homola, Ronald K. Dunton
-
Patent number: 5972312Abstract: A liquid oral composition is disclosed which contains a cationic bactericide as the active ingredient and a hydroxypropyl methyl cellulose. The composition has satisfactory long-term stability and can be ejected from a container and easily applied to oral tissues. It can be kept adherent especially to the surfaces of teeth for a certain period.Type: GrantFiled: March 11, 1998Date of Patent: October 26, 1999Assignee: Sunstar Inc.Inventors: Sayuri Tanii, Tomoko Ito
-
Patent number: 5961958Abstract: The present invention discloses compositions containing a transfer agent and/or bactericidal compounds, and hydrophobic materials which form, upon application to dental surfaces, adhesive, protective and bacteria-inhibiting barriers.Type: GrantFiled: July 16, 1996Date of Patent: October 5, 1999Assignee: Four Star PartnersInventors: Andrew M. Homola, Ronald K. Dunton
-
Patent number: 5958381Abstract: A dual component chlorhexidine dentifrice composition in which the first component contains a bis-biguanide antibacterial agent and the second component contains an abrasive incompatible with the bis-biguanide, wherein maximum antibacterial effect on dental tissue with reduced staining is achieved when the components and are physically separated prior to use and are mixed upon application to dental tissue.Type: GrantFiled: March 12, 1998Date of Patent: September 28, 1999Assignee: Colgate Palmolive CompanyInventors: John P. Curtis, Alexander J. Simone, Susan Greenfeder, Zehra Siddiqui
-
Patent number: 5948390Abstract: A stable oral rinse or clear oral gel composition, comprising:a) about 0.01% by weight to about 1% by weight of hydrated zinc cations;b) about 0.01% by weight to about 4% by weight of fully or partially protonated citrate moieties;c) about 0.01% by weight to about 2% by weight of cetyl pyridinium cations; andd) an orally acceptable vehicle;wherein said composition has a pH of from about 3.0 to about 4.5.Type: GrantFiled: August 18, 1998Date of Patent: September 7, 1999Assignee: Pfizer Inc.Inventors: Dennis G. A. Nelson, Alenjandro V. Ortega, II
-
Patent number: 5945089Abstract: A method of treating mucositis in immunocompromised patients is disclosed which is based on contacting the affected area with an amount of composition which comprises triclosan in an amount which is effective to alleviate the symptoms of mucositis.Type: GrantFiled: November 5, 1998Date of Patent: August 31, 1999Assignee: I-Dent International CorporationInventor: Barry Libin
-
Patent number: 5939050Abstract: Antimicrobial compositions comprising at least two antimicrobial agents exhibit reduced MIC values relative to the MIC for the agents making up the combination when measured alone. The compositions are useful as therapeutic agents such as in oral hygiene products.Type: GrantFiled: April 4, 1997Date of Patent: August 17, 1999Assignee: Optiva Corp.Inventors: Lokanathan M. Iyer, James R. Scott, Douglas F. Whitfield
-
Patent number: 5932193Abstract: Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethyl cellulose and hydrated thickening silica.Type: GrantFiled: September 23, 1997Date of Patent: August 3, 1999Assignee: Hercules IncorporatedInventors: Jean-Paul Lopez, Mohand Melbouci, Gerhard Dewald
-
Patent number: 5925335Abstract: An orally absorbable improved dental formulation is provided. The dental formulation includes a base to which an active component is added. The active component comprises, based on the overall weight thereof, Vitamin C in an amount between about 10 and 25 weight percent, and coenzyme Q-10 (or ubiquinone), in an amount between 10 and 25 weight percent, are added.Type: GrantFiled: June 12, 1997Date of Patent: July 20, 1999Assignee: C.S. Bioscience Inc.Inventors: David J. Shuch, Gerald P. Curatola
-
Patent number: 5906811Abstract: The combination of several synergistic antioxidants, enzymatic co-factors and amino acids in appropriate delivery vehicles employed in aerosol carriers, mist and pump oral sprays, solutions, such as oral irrigators, mouth rinses and mouthwashes, or gels and solid compositions as a means of preventing and ameliorating signs and symptoms and complications to the oro-pharyngeal cavity and mouth including buccal mucosa, gums and tongue and the upper respiratory tract from damage caused by free radical species induced by tobacco smoke, smokeless tobacco, ingested or chewed noxious, malodorous or harmful substances and other inhaled environmental pollutants and particulate matter, including tobacco to secondary smokers.Type: GrantFiled: June 27, 1997Date of Patent: May 25, 1999Assignee: Thione International, Inc.Inventor: Theodore Hersh
-
Patent number: 5904928Abstract: The invention relates to an anti-tartar composition comprising:(a) 0.5 to 5% by weight of at least one compound selected from among zirconium silicate and hydrated silica;(b) 0.5 to 5% by weight of at least one compound selected from among chlorhexidine digluconate and zinc digluconate;(c) 0.5 to 5% by weight of at least one compound selected from among potassium thiocyanate, glucose oxidase, lysozyme, and lactoperoxidase; and(d) 1 to 5% by weight of at least one acid compound selected from among vitamin C and citric acid.It also concerns the use thereof in combination with food supplements or chewable supports for animals as well as the food supplements and chewable articles thus obtained.The invention applies, in particular, to the control of the formation of tartar in domestic animals such as dogs.Type: GrantFiled: April 18, 1997Date of Patent: May 18, 1999Assignee: Societe a Responsabilite LimiteeInventors: Jean-Paul Cyr, Jean-Marc Denoun
-
Patent number: 5902110Abstract: A method for reducing bone resorption at tooth extraction sites by topically applying a prostaglandin inhibitor, such as a non-steroidal anti-inflammatory drug (NSAID) to the affected area. The preferred NSAID is ketoprofen. The composition may also include a penetration enhancer such as vitamin E.Type: GrantFiled: November 3, 1997Date of Patent: May 11, 1999Assignee: The Block Drug CompanyInventors: Michael C. Alfano, Emanual S. Troullos
-
Patent number: 5898037Abstract: This invention provides novel pharmaceutical compositions which comprise magnesium compounds in hypertonic amounts. These compositions are formulated for local application for the treatment of conditions such as acne, arthritis, periodontal disease ophthalmic conditions (e.g., conjunctivitis), hemorrhoids, vaginal infections and inflammation, and ulcerative colitis. The compositions are formulated with an acceptable dermatological, oral, rectal, vaginal, or ophthalmic carrier for use in treating these conditions. Also provided is a method for treating asthma wherein the magnesium compositions are administered by inhalation. Any of these treatments, and especially that for asthma, can be supplemented with oral administration of magnesium.Type: GrantFiled: July 11, 1996Date of Patent: April 27, 1999Inventor: Alvin J. Marx
-
Patent number: 5888480Abstract: The present invention discloses compositions containing lecithin and/or bactericidal compounds, and hydrophobic materials which form, upon application to dental surfaces, adhesive, protective and bacteria-inhibiting barriers.Type: GrantFiled: June 7, 1995Date of Patent: March 30, 1999Assignee: Four Star PartnersInventors: Andrew M. Homola, Ronald K. Dunton
-
Patent number: 5879663Abstract: There is provided a dental composition for relieving dentin hypersensitivity, which occludes dentinal tubules having an opening on the surface of dentin to relieve dentin hypersensitivity thereby to give an immediate relieving effect and to maintain the relieving effect for a long time.The dental composition for relieving dentin hypersensitivity, which comprises (A) a low molecular weight compound which can produce a precipitate which is hardly soluble in water when it reacts with a calcium compound, or which comprises the above component (A), (B) a calcium compound and/or (C) an aqueous polymer emulsion having a particle size smaller than that of a dentinal tubule and forming an agglomerate or a hardly soluble gel larger than the diameter of a dentinal tubule when it reacts with a calcium compound.Type: GrantFiled: August 7, 1996Date of Patent: March 9, 1999Assignees: Sun Medical Co., Ltd., Nobuo NakabayashiInventors: Nobuo Nakabayashi, Takashi Yamamoto, Yasukazu Saimi, Masami Arata, Harumi Tanaka
-
Patent number: 5876701Abstract: A striped and/or speckled dentifrice stable to color bleeding, wherein at least one dentifrice component contains a colorant entrained in a high density polyethylene matrix having a melting point range as measured by DSC is between about 110.degree. C. and about 145.degree. C., whereby on storage substantially no visually observable colorant bleeding is present in any other dentifrice component.Type: GrantFiled: February 27, 1998Date of Patent: March 2, 1999Assignee: Colgate Palmolive CompanyInventors: Mike Wong, Michael Prencipe
-
Patent number: 5874068Abstract: An antiplaque and antigingivitis effective oral composition containing a stabilized N.sup..alpha. -acyl acidic amino acid ester salt is disclosed. Also disclosed is a method for inhibiting plaque buildup in the oral cavity with an oral composition containing the stabilized N.sup..alpha. -acyl acidic amino acid ester salt.Type: GrantFiled: December 8, 1997Date of Patent: February 23, 1999Assignee: Warner-Lambert CompanyInventors: E. Eric Engelman, Lynn Schick, Mona Nair, R. Michael Buch
-
Patent number: 5855872Abstract: A composition for treating diseased tissues resulting from a herpes simplex virus infection. When in ointment form, the composition has dispersed in an oil and water emulsion two distinct antimicrobial agents, one being Triclosan which is non-cationic and water insoluble, the Triclosan being solubilized by a solubilizer. The second antimicrobial agent which is cationic and water-soluble, is combined with the solubilized Triclosan to produce an antimicrobial composite that is polar and retained by the diseased tissues to which it is applied.Type: GrantFiled: September 19, 1997Date of Patent: January 5, 1999Inventor: Barry M. Libin
-
Patent number: 5855870Abstract: The present invention discloses sticky dental compositions and methods for treating sensitive teeth. For maximum comfort, an improved dental tray that is thin-walled, flexible and lightweight is used to hold the dental composition adjacent the desired tooth surfaces. The dental compositions include a sticky matrix material into which is dispersed a desensitizing agent such as KNO.sub.3 and other optional dental agents. The matrix material preferably includes carboxypolymethylene that has been partially neutralized with a base to reduce etching of the enamel. The carboxypolymethylene adds a unique stickiness to the dental composition which helps to adhere and retain the soft tray material against the patient's teeth.Type: GrantFiled: May 30, 1997Date of Patent: January 5, 1999Assignee: Ultradent Products, Inc.Inventor: Dan E. Fischer
-
Patent number: 5853703Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.Type: GrantFiled: January 18, 1996Date of Patent: December 29, 1998Assignees: The Picower Institute for Medical Research, Alteon Inc.Inventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan
-
Patent number: 5851551Abstract: A sustained-release matrix for dental application includes either an anti-microbial agent or a colorant that is released from the matrix when the matrix contacts water. The preferred matrices include a water-soluble polymer and a water-insoluble support resin.Type: GrantFiled: June 21, 1994Date of Patent: December 22, 1998Assignee: The Gillette CompanyInventors: Mingchih M. Tseng, Carl M. Philbrook
-
Patent number: 5849266Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: April 4, 1995Date of Patent: December 15, 1998Assignee: Perio Products Ltd.Inventor: Michael Friedman
-
Patent number: 5840281Abstract: An antiplaque composition comprising a bacteriocin such as nisin and a polyphosphonate.Type: GrantFiled: August 11, 1994Date of Patent: November 24, 1998Assignee: Colgate Palmolive CompanyInventors: Abdul Gaffar, John Afflitto, Malathy Subramanian
-
Patent number: 5833958Abstract: A dentifrice formulation provides a composition which contains and antibacterially effective amount of a lanthocin-type bacyeriocin antibacterial agent such as nisin, gramicidin, or tyrothicin and an orally acceptable low anion or anio-free excipient mixture containing a purified surfactant selected from nonionic surfactant, cationic surfactant and amphoteric surfactant so as to avoid anionic surfactant; a low or anion or anion-free abrasive; a nonionic thickening agent; a humectant; and a fluoride ion producing compound.Type: GrantFiled: June 15, 1994Date of Patent: November 10, 1998Assignee: AMBI Inc.Inventors: Geoffrey Royston Doel, Andrew William Smith
-
Patent number: 5827503Abstract: Oral hygiene is improved and diseases of the oral cavity are treated by oral application of a composition containing 0.02 to 0.25 weight percent alkyldimethylbenzylammonium chloride (BAC) and 0.05 to 2.0 weight percent sodium chloride dissolved in water, in the absence of other active ingredients. The BAC and sodium chloride act synergistically to allow the composition to sorb strongly to oral tissues and remain there for several hours.Type: GrantFiled: August 8, 1996Date of Patent: October 27, 1998Assignee: Collagenex Pharmaceuticals, Inc.Inventor: Christian Schwabe
-
Patent number: 5814331Abstract: A process for inhibiting the growth of pathogenic bacteria and aiding in periodontal tissue healing within the oral cavity by binding therapeutic agents to surfaces is described. The process includes initial coating of hard surfaces in the oral cavity such as tooth roots, dental restorative materials, dental implants, and guided tissue regeneration surgery barrier membranes with a cationic surfactant, tridodecylmethylammonium chloride, and then binding antibiotics such as tetracycline, metronidazole or with Platelet Derived Growth Factor. These surfaces are thereby made unavailable for bacterial colonization. Tooth roots, barrier membranes and other materials used in regenerative periodontal surgery also may be coated with cationic surfactant to bind local or added platelet derived growth factors.Type: GrantFiled: November 13, 1995Date of Patent: September 29, 1998Inventor: Sheldon Holen
-
Patent number: RE36419Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.Type: GrantFiled: March 27, 1998Date of Patent: November 30, 1999Assignee: The Procter & Gamble CompanyInventor: Paul Francis Cavanaugh, Jr.