Abstract: An oral composition and method for use thereof, comprising in an orally acceptable vehicle, an effective antiplaque amount of a noncationic antibacterial agent, and an anionic copolymer formed from monomers of which about 40 to about 90% by weight are hydrophilic type capable of attachment to oral surfaces and about 10 to about 60% by weight are of a hydrophobic type; such oral composition being effective in increasing the uptake of the antibacterial compound to dental tissue so as to enhance the therapeutic efficacy of the administered antibacterial compound.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.

Abstract: This invention relates to a method and composition for inhibiting or destroying viruses or retroviruses in a mammalian host. The method comprises contacting the viruses or retroviruses with a composition. The composition comprises an active ingredient capable of inhibiting or destroying viruses or retroviruses, for example, a surfactant, and an activating ingredient capable of inhibiting or destroying one or more enzymes associated with viruses or retroviruses, for example, a fluorinated compound capable of releasing fluoride anions, and an excipient.

Abstract: New compositions comprising an abrasive system comprising an alkali metal bicarbonate and a surfactant system comprising a non-ionic poly(hydroxypropyl ether) surfactant, which are characterized in that the said surfactant system further comprises an alkali metal, alkaline-earth metal or ammonium lauryl sulphate, particularly a sodium lauryl sulphate or a magnesium lauryl sulphate. Such compositions are in particular oral hygiene compositions.The invention also relates to the use of these compositions as, or for the manufacture of, a dentifrice in the form of a paste, a gel, a liquid or a chewing gum.

Abstract: Shaving compositions for use in the personal shaving process with a razor blade assembly include insoluble solid particulate additives. The shaving compositions may include one or more of the following: wetting agents, cleansing agents, lather producing compositions, emollients and mixtures thereof; and further includes at least one solid, insoluble particulate additive in a well dispersed suspension throughout said shaving composition. The solid additives are present in an effective amount to produce physical microscopic support for the blade of a razor blade assembly during the personal shaving process. By providing micro-support of the razor blade parallel to skin surface and above surface irregularities, the solid particulate additives provide improved razor blade glide, thereby preventing nicks and cuts, and also enhancing exfoliation of dead skin and removal of grease and oils, as well as improving hair extraction prior to cutting, thereby improving overall smoothness of the post-shaven skin.

Abstract: An anti-microbial composition includes particles having an outer surface onto which an anti-microbial agent has been adsorbed. The particles can be used, for example, for coating the bristles of toothbrushes.

Abstract: Disclosed is streptococcus suis adhesin protein, a method for producing it, and antibodies against the adhesin protein. Pigeon ovomucoid or a synthetic derivative is used in the identification of the adhesin protein. The adhesin protein and the antibodies may be used both diagnostically and therapeutically. The adhesin protein and its derivatives and fragments and the corresponding polynucleotides can also be used as a vaccine.

Abstract: The present invention relates to oral hygiene and specifically to an improved method for adding chemotherapeutic agents to dental floss containing several multi-fiber bundles, to methods of treating the oral cavity with the improved dental floss and to the improved dental flosses per se.

Abstract: An oral hygiene composition comprises a cationic antimicrobial agent (such as chlorhexidine gluconate), an anionic active agent (such as an alkali metal pyrophosphate) and both a non-ionic surfactant having a high hydrophilic/lipophilic balance (such as an ethoxylated castor oil) and an amphoteric surfactant (such as cocoamidopropyl betaine).

Abstract: An oral composition comprising in an orally acceptable vehicle, an effective antiplaque amount of an halogenated diphenyl ether or phenolic antibacterial compound, and an amount of an mixed anionic/nonionic surfactant system at weight ratios of about 14:1 to 9:1 which ratios are effective to increase the uptake of the antibacterial compound to dental tissue so as to enhance the therapeutic efficacy of the administered antibacterial compound.

Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.

Abstract: New lysine derivatives containing a containing an alkylsulphonyl or alkylaminocarbonyl group of formula (I):COOH--CH(NH.sub.2)--(CH.sub.2).sub.4 --NH--Xin which X represents an --SO.sub.2 R or --CONHR group, where R represents a linear or branched, saturated or unsaturated, alkyl radical having from 8 to 22 carbon atoms, salts thereof, and mixtures of the derivatives and the salts. A process for the preparation of these derivatives, salts, and mixtures and use of such derivatives, salts, and mixtures, especially in cosmetics. Compositions, especially cosmetic compositions, comprising the derivatives, salts, and mixtures.

Abstract: The present invention relates to a mouthrinse and methods of use providing improved antimicrobial activity and thereby reducing oral bacteria, mouth malodor and further promoting oral health.

Abstract: The present invention relates to a mouthrinse and methods of use providing improved antimicrobial activity and thereby reducing oral bacteria, mouth malodor and further promoting oral health.

Abstract: Oral compositions comprising the combination of an effective surface tension reducing amount of an amphoteric surfactant and an effective antimicrobial amount of a blend of phenolic agents is disclosed. These compositions are indicated in the management or control of dental plaque.

Abstract: The present invention discloses applicators containing cationic surface active agents, hydrophobic barrier-forming materials and antimicrobial compounds which form, upon application to dental surfaces, a protective and bacteria-inhibiting film.

Abstract: A process is provided which is useful in alleviating inflammation of gums, bone loss and detachment of teeth in a patient in need of such treatment. The process comprises administering a vasodilator to the inflamed gum tissue and other affected tissue, either topically or by injection. Advantageously, the vasodilator is papaverine or a pharmaceutically acceptable salt thereof such as papaverine hydrochloride. Advantageously, the papaverine hydrochloride may be administered topically in a composition comprising a carrier such as an aqua based transparent gel dental vehicle. The carrier dissolves the papaverine hydrochloride and enables it to penetrate the soft tissue of the gums and be absorbed into the inflamed tissue.

Abstract: Antimicrobial compositions useful in the treatment of microbial infections and as general cleansers are provided along with methods for their administration. The antimicrobial compositions are aqueous based and preferably contain a quaternary ammonium compound as a antimicrobial agent. The antimicrobial compositions also preferably contain a surfactant such as a cationic, nonionic, or amphoteric surfactant or mixtures thereof. A keratolytic agent, such as allantoin, is also preferably blended into the antimicrobial compositions. The antimicrobial compositions are ideally suited for subcutaneous, cutaneous, or mucosal membrane administration.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: An oral composition exhibiting reduced irritability to oral tissue is disclosed wherein the composition contains a surfactant system comprised of a combination of an anionic surfactant such as sodium lauryl sulfate and a C.sub.12 -C.sub.22 alkyl glycoside.

Abstract: The present invention relates to anti-bacterial compositions comprising particular compounds, to the use of the compounds as anti-bacterial agents, to the preparation of therapeutic or medicinal compositions comprising the compounds and to a method of disinfecting matter including the step of treating matter with the compounds. The compounds are identified as peptides having a molecular weight of at least 5 kD, comprising at least 15% by number of residues of arginine, lysine, ornithine or a mixture thereof and at least 15% by number of residues of arginine, lysine, ornithine, phenylalanine, tyrosine, tryptophan or a mixture thereof. Although the invention is described with reference to used in the fields of food and oral hygiene, the invention has particular utility in the field of household and/or industrial hygiene.

Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.

Abstract: In an oral composition comprising a cationic bactericide, either one or both of cyclodextrin and a water-soluble flavor obtained by extracting an oil-soluble flavor with an aqueous ethanol solution are blended. The composition allows the cationic bactericide to exert its activity to a full extent, presents a pleasant feel on use without any peculiar taste, and is stable during storage. The invention eliminates the use of anionic and nonionic surfactants.

Abstract: A method for inhibiting bacteria in the mouth of a patient which includes placing a particle containing a degradable material and an anti-microbial agent in the mouth of the patient. The exterior of the particle is water-stable. The particles may be coated on dental floss or the bristles of a toothbrush, or incorporated into an oral rinse. Once placed in the mouth, the degradable material degrades to cause release of the anti-microbial agent, resulting in the inhibition of bacteria in the mouth.

Abstract: Copolymers of polyaspartic acid which are suitable for the inhibition of scale deposition were obtained by reacting maleic acid, an additional polycarboxylic acid and ammonia in a stoichiometric excess, at 120.degree.-350.degree. C., preferably 180.degree.-300.degree. C., to provide copolymers of polysuccinimide. In a second embodiment, a polyamine was added to the reaction mix. These intermediate polysuccinimide copolymers could then be converted to the salts of copolymers of polyaspartic acid by hydrolysis with a hydroxide.Such copolymers are useful in preventing deposition of scale from water and find applications in treating water. Other applications include scale prevention additives for detergents. In addition, such copolymers inhibit dental tartar and plaque formation.

Abstract: This invention provides a single-phase aqueous solution of a zinc-polyamine complex which is stable and has a clear transparency. The aqueous solution can be incorporated as a component of an oral care product such as a mouthwash or toothpaste. The zinc-polyamine complex enhances the control of oral malodor, plaque, calculus and gingivitis in dental applications, and decreases the astringency and metallic taste which is characteristic of zinc ions in an oral cavity.

Abstract: Shaving compositions for use in the personal shaving process with a razor blade assembly include insoluble solid particulate additives. The shaving compositions include a mixture of at least one wetting agent, at least one cleansing agent, at least one lather producing composition, and at least one emollient; and further include at least one solid, insoluble particulate additive in a well dispersed suspension throughout said shaving composition. The solid additives are present in an effective amount to produce physical microscopic support for the blade of a razor blade assembly during the personal shaving process. By providing micro-support of the razor blade parallel to skin surface and above surface irregularities, the solid particulate additives provide improved razor blade glide, thereby preventing nicks and cuts, and also enhancing exfoliation of dead skin and removal of grease and oils, as well as improving hair extraction prior to cutting, thereby improving overall smoothness of the post-shaven skin.

Abstract: Oral compositions, such as oral gels, toothpastes and mouthwashes, containing a chelating agent and a hydrophobic anionic surfactant.

Abstract: An anti-microbial composition includes particles having an outer surface onto which an anti-microbial agent has been adsorbed. The particles can be used, for example, for coating the bristles of toothbrushes.

Abstract: A pleasant tasting antimicrobial mouthwash formulation which maintains clarity for removal of dental plaque where no alcohol, sugar, artificial sweeteners are used making it suitable for safe use by alcoholics, diabetics, persons under medical treatment or taking medications which prelude the use of alcohol, hospitalized patients, prison inmates, minors and all other persons who can not or should not subject themselves to alcohol, sugar, or artificial sweeteners. The formulation consists of water, glycerin, sodium benzoate, cetylpyridinium chloride, citric acid, maltol, xylitol, a flavoring agent to give a pleasant though biting taste, and a coloring agent.

Abstract: A pharmaceutical composition contains chlorhexidine and glutaraldehyde in a pharmaceutically acceptable carrier; in the form of a mouthwash, the composition is effective in controlling fungal or yeast infections in the oral cavity, such as associated with subjects suffering from AIDS, cancer and periodontal diseases; in particular the composition is effective against fungi of the genus Candida including Candida albicans and Candida krusei.

Abstract: The present invention relates to a low-irritation anesthetic and antiseptic mouth rinse. The mouth rinse is freeze-thaw stable and is prepared using polyethylene glycol having a number average molecular weight of 200 to 300 which have been found to be compatible with local anesthetics and other ingredients commonly used in mouth rinses.

Abstract: The present invention relates to a method of reducing the adherence of bacteria to tooth surfaces, to compositions for use in such a method and to processes for the preparation thereof.

Abstract: Oral composition containing an effective amount of N-methylpyrrolidone alone or in combination with a noncationic antibacterial agent such as Triclosan for topical application for the prevention of plaque, gingivitis and/or caries.

Abstract: An improved tooth, gel or paste which includes silicon dioxide, aloe vera and allantoin which cures and prevents the formation of lesions and aphthous ulcers minor and other ailments on the oral mucosa.

Abstract: A chewing gum or wax base is mixed with a tooth whitening agent such as carbamide peroxide and is conditioned into pieces of chewing gum or wax. Mastication of these on a regular basis helps in whitening teeth in a person in need of a tooth whitening treatment.

Abstract: A solid, oral, anticariogenic composition in the form of a chewing gum or a lozenge and beyond the conventional chewing gum or lozenge ingredients containing as dental plaque acid-neutralizing ingredient urea in an amount from 0.5% by weight to 80% by weight, based on the total weight of the composition, an optional coating not being taken into account.The composition is used for reducing the risks of dental caries subsequently to eating and drinking as it causes a neutralization of the plaque acids.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: Composition for the treatment of gingivitis and other afflictions of the oral cavity, as well as for the reduction of dental plaque. These are in the form of gels, solutions or similar forms which comprise a therapeutically active agent in a polymeric carrier which contains a solvent. The nature of the preparation is such that when these are applied to an aqueous environment of the oral cavity, the polymer and the active agent precipitate and form a coating.

Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

Abstract: The invention relates methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.

Abstract: Dentifrices, including toothpaste creams and gels, and mouthwashes, are provided including aminoalkyl silicones. In the mouth, the aminoalkyl silicones form a lasting hydrophobic film on the teeth for prevention of cavities and stain. Antimicrobial compounds such as chlorhexidine may be included.

Abstract: Dental caries are prevented by contacting teeth with an edible composition containing micellar casein which has been isolated from an animal milk and which is incorporated in the composition in an amount sufficient to inhibit oral colonization by Streptococcus sobrinus.

Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.

Abstract: A method for suppressing a bitter taste of material to be placed in mouth or in contact with mouth, such as foods, drinks, pharmaceuticals, comprises adding an acidic phospholipid or an acidic lysophospholipid to the material.

Abstract: A non-alcoholic, aqueous mouthwash composition is provided which contains a dispersion system containing a non-ionic surfactant selected from an hydrogenated castor oil and a polyoxyethylene polyoxypropylene block copolymer having about 50% to about 90% ethylene oxide, a humectant and a cationic antimicrobial agent. The composition exhibits a homogeneous, uniform appearance and a high degree of bacterial efficacy.

Abstract: Concentrated mouthrinse, methods of use and methods of manufacturing the mouthrinse for efficient delivery of antimicrobials wherein the composition is concentrated and substantially free of non-cationic surfactants.