Abstract: The invention relates to an oral composition for the treatment and prevenn of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.

Abstract: A process for enhancing oral hygiene by reducing oral microflora and for inhibiting the formation of dental plaque in a subject by applying to the oral cavity a composition containing 0.1 to 40 parts, by weight, of a higher alkyl-N-sulfobetaine having the structure ##STR1## where R is a higher alkyl group of from 10 to 18 carbon atoms and b) 0.1 to 40 parts, by weight, of a higher alkyl-N,N-dimethylamine oxide, a higher alkyl-N,N-dihydroxylethylamine oxide, or an acylamide t-amine oxide having the respective structures: ##STR2## wherein R is a higher alkyl of from 10 to 18 carbon atoms, or mixtures of said amine oxides.

Abstract: An oral anti-halitosis preparation adapted to desorb microorganisms and to absorb materials causing halitosis, includes as an active ingredient a synthetic oil, preferably one containing the ester of an alcholol and an aliphatic acid of at least six carbon atoms. Particularly good results were obtained when the synthetic oil is caprylic triglyceride, capric triglyceride, or mixtures thereof.

Abstract: A chlorhexidine adduct is described, which comprises one molecule of chlorhexidine with three molecules of hydrogen fluoride and one molecule of hydrogen tin trifluoride. The adduct displays a high antibacterial effectiveness against Streptococcus mutans even in very low concentrations.

Abstract: Antimicrobial etchant compositions exhibiting good stability and antimicrobial and tooth decalcification are disclosed. The claimed compositions, kits and methods comprise use of antimicrobially effective amounts of benzalkonium chloride, preferably between about 0.1% to about 4.0% together with from about 5% to about 55% phosphoric acid or other concentration of other suitable etchants. The claimed compositions and methods provide concomitant tooth etching and impartation of antimicrobial activity, simplifying the tooth restorative process.

Abstract: The present invention relates to oral compositions in the form of microcapsules which reduce oral bacteria and provide long lasting breath protection.

Abstract: Pathogenic microorganisms such as Staphylococcus aureus are differentiated and identified by observing the selective inhibition of the microorganism which occurs when it is contacted with Alphazurine A dye.

Abstract: A composition for use in the oral cavity is disclosed. The composition comprises (A) an antibacterial compound represented by the following general formula (1),A.sup.m+ .multidot.X.sub.m.sup.- (1)wherein A.sup.m+ is a nitrogen-containing antibacterial cation and the counter anion X.sup.- represents a monoalkyl phosphate ion, a monoalkenyl phosphate ion, a monoalkyl phosphonate ion, or a monoalkenyl phosphonate ion having a linear or branched alkyl or alkenyl group with 8 to 20 carbon atoms, and m is a valence of the cation A, and (B) a vehicle for use in the oral cavity. It exhibits a remarkablely rapid and continued disinfection effect action against oral cavity bacteria, while providing a good taste. Its disinfection effect is not reduced in the presence of surfactants. In addition, it does not color the tooth.

Abstract: A dentifrice for desensitizing sensitive teeth wherein a potassium salt of a synthetic anionic polymer is present to close off subsequent penetration of pain to dental pulp.

Abstract: A composition for use in the oral cavity comprising a monophosphate represented by the following general formula (1), ##STR1## wherein R.sup.1 is a linear or branched alkyl or alkenyl group with 6 to 20 carbon atoms, and may have a substituted fluorine atom; one of X.sup.1 or X.sup.2 is a basic amino acid residual group, while the other is a hydrogen atom, an alkali metal, an ammonium, an alkyl amine, an alkanol amine, or a basic amino acid residual group; and n is an integer from 0 to 4. The composition exhibits a superior action in protecting the tooth surface, is stable, and has a pleasant taste.

Abstract: An antiplaque composition comprising a bacteriocin such as nisin and a polyphosphonate.

Abstract: Oral composition containing an effective amount of N-methylpyrrolidone alone or in combination with a noncationic antibacterial agent such as Triclosan for topical application for the prevention of plaque, gingivitis and/or caries.

Abstract: The subject invention relates to methods for prevention or treatment of gingivitis or periodontitis comprising topical administration, to gingival tissues of the oral cavity, of a composition comprising a safe and effective amount of a selective histamine-2 receptor antagonist compound, and oral care compositions used therefore.

Abstract: A method of treating aphthous ulcers and other mucocutaneous disorders is disclosed. The method comprises contacting the mucocutaneous disorder with a composition in the form of a paste, solution, gel, quick-disintegrating tablet, mouthwash, ointment, cream, powder, adhesive patch, aerosolized spray, lozenge, troche, dentifrice, or dental floss that contains an effective amount of an active compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy, carboxyalkyl (i.e. esters), cyano, acylamino, or amino group which may be unsubstituted or substituted by up to two alkyl groups; m is 0, 1 or 2 and R.sub.2 is alkyl, alkenyl, alkoxy, halgoen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms, cyano, carboxyalkyl, trifluoromethyl, or amino group which may be unsubstituted or substituted by at least one alkyl; and R.sub.

Abstract: Oral hygiene antiplaque compositions which include as an active ingredient an amino sugar containing a sugar moiety recognized by lectins on oral bacteria (e.g., .beta.-D-galactose, .beta.-D-N-acetyl galactosamine, L-rhamnose and .beta.-D-fucose) and in which nitrogen is linked to carbon number 1. The amino sugars singly or in combination with each other provide enhanced inhibition of bacterial aggregation, surfactancy, and antimicrobial activity.

Abstract: The subject invention encompasses methods and compositions comprising N-acetylated amino acid complexes for reducing or preventing dental plaque, calculus, or gingival or periodontol diseases of the oral cavity in humans or lower animals.

Abstract: This invention provides a mouthwash composition which is in the form of a concentrated aqueous ethanolic formulation of ingredients. An essential aspect of an invention mouthwash is an alkali metal bicarbonate ingredient which is present as a suspension phase of ultrafine particles. The suspension phase also can have a content of colloidal zinc oxide. Oral hygiene is practiced by diluting an invention mouthwash concentrate with water, and rinsing the oral cavity with the diluted liquid medium.

Abstract: The invention relates to an oral composition for plaque prevention or tooth hypersensitivity comprising either an antibacterial agent or a hypersensitivity agent embedded in a sustained release carrier such as an acrylic polymer, and a method for the use of said compositions in preventing dental caries, periodontal disease, and tooth hypersensitivity.

Abstract: Oral compositions and methods effective in promoting oral hygiene containing in an effective amount at least one cyclic alkylamine or cyclic amine as an antiplaque and/or antigingivitis agent.

Abstract: Oral compositions containing an effective amount as an anticalculus agent at least one cyclic alkylamine or cyclic amine in the presence or absence of a cationic antimicrobial agents.

Abstract: An oral composition comprises a nonionic antimicrobial or germicidal agent and at least one amphoteric surface active agent selected from the group consisting of compounds of the following general formulae (1) and (2): ##STR1## wherein R represents an alkyl group having 1 to 18 carbon atoms, and n and m are independently an integer of from 1 to 10. The composition preferably further comprises an alkyl sulfate.

Abstract: Dentifrice compositions including specific aldobionamides having a .beta.-galactosidic linkage e.g., lactobionamides, which act as antimicrobial agents and/or inhibitors of bacterial adhesion.

Abstract: A chlorohexidine adduct comprising one molecule of chlorohexidine with six molecules of hydrogen fluoride and a process for its preparation are described, said adduct displaying a high anti-bacterial effectiveness vis-a-vis Streptococcus mutans even in very small concentrations and being valuable as anti-plaque agent and for caries prevention.

Abstract: An anti-microbial composition includes particles having an outer surface onto which an anti-microbial agent has been adsorbed. The particles can be used, for example, for coating the bristles of toothbrushes.

Abstract: Oral compositions containing phytic acid or a physiologically acceptable salt thereof, a cationic antimicrobial compound and a compatibilizing agent are disclosed for controlling dental calculus, dental plaque, gingivitis, periodontitis and/or oral malodor.

Abstract: An oral composition of acceptable taste substantially non-irritating to oral tissue and stable to viscosity change during storage is disclosed wherein the composition contains a surfactant system comprised of a sodium lauryl sulfoacetate surfactant purified to contain less than 18% by weight impurities and an C.sub.12 -C.sub.22 alkyl glycoside.

Abstract: The subject invention relates to methods for prevention or treatment of gingivitis or periodontitis comprising topical administration, to gingival tissues of the oral cavity, of a composition comprising a safe and effective amount of a selective histamine-2 receptor antagonist compound, and oral care compositions used therefore.

Abstract: A non-alcoholic, aqueous mouthwash composition is provided which contains a dispersion system containing a non-ionic surfactant selected from an hydrogenated castor oil and a polyoxyethylene polyoxypropylene block copolymer having about 50% to about 90% ethylene oxide, a humectant and a cationic antimicrobial agent. The composition exhibits a homogeneous, uniform appearance and a high degree of bacterial efficacy.

Abstract: There is disclosed an oral composition including an organosilicon-type quaternary ammonium salt immobilized on a water-insoluble solid carrier. In particularly, an oral composition in an aqueous system according to the present invention includes an organosilicon-type quaternary ammonium salt immobilized on a water-insoluble solid carrier in combination with at least one surfactant selected from the group consisting of polyoxyethylene-polyoxypropylene block copolymers and alkylolamides as a stabilizing agent; at least one thickening agent selected from the group consisting of nonionic thickening agents and cationic thickening agents; and optionally at least one alcohol selected from the group consisting of ethanol, propanol and isopropanol as a dispersing agent.

Abstract: An oral composition of acceptable taste substantially non-irritating to oral tissue, the composition containing an effective amount of a sodium lauryl sulfoacetate surfactant purified to contain less than 18% by weight impurities. An amount of a nonionic or amphoteric compound is included in the composition to enhance the foaming ability of the purified sodium lauryl sulfoacetate surfactant as well as to further reduce its irritancy potential.

Abstract: A tooth whitening formulation comprising urea peroxide (1:1) in a concentration of 22-32% based on the total weight of the formulation, in combination with a gelling agent, is provided in accordance with the present invention. The invention also provides a method for whitening the teeth using said formulation wherein the formulation is applied to the teeth using a splint which keeps the formulation in contact with the teeth for a period of time sufficient to cause whitening thereof.

Abstract: The subject invention encompasses methods and compositions comprising N-acetylated amino acid complexes for reducing or preventing dental plaque, calculus, or gingival or periodontol diseases of the oral cavity in humans or lower animals.

Abstract: An oral composition for suppressing mouth odors comprising from about 0.001 to about 10 percent by weight of a copper salt and from about 0.001 to about 10 percent by weight phytic acid or a physiologically acceptable salt thereof. A cationic antimicrobial compound is added to the oral composition to aid in the prevention of plaque formation and gingivitis provided the oral composition contains from about 0.01 to about 20 percent by weight of a compatibilizing agent.

Abstract: The invention relates to alcohol-free, oral pre-rinse and rinse emulsions containing cleaning and coating compositions that are non-irritating and low foaming thus allowing a residence time sufficient to condition teeth and gums and disruptively affect the plaque matrix. Such disruption allows for the reduction of plaque build-up by either of two efficacious and convenient mechanisms: (1) immediate removal of disrupted plaque matrix by normal brushing or (2) interruption of plaque forming activity in the mouth by frequently cleaning out plaque and plaque precursors, coupled with reduced attachment of plaque by altering the tooth surfaces with the coating compositions.

Abstract: The present invention relates to compositions and methods which are effective against alveolar bone resorption and enhance the ability of a tooth moved in orthodontic therapy to remain in its new position or to stay in its original position when adjacent teeth are moved.

Abstract: Combinations of fluoride or monofluorophosphate with phosvitin or soluble salts thereof provide superior protection against demineralization of tooth enamel when used in oral hygiene compositions such as toothpastes and mouthwashes.

Abstract: An antiplaque oral composition such as a gel, paste or mouthrinse which is comprised of a vehicle having incorporated therein as the antiplaque agent an effective amount of an antibacterial salicylanilide compound and a surfactant mixture of an anionic surfactant, a polyoxyethylene/polyoxypropylene block copolymer and a taurate salt, the pH of the composition being adjusted to a pH of at least 8.0. An antibacterial-enhancing agent such as an anionic polymeric polycarboxylate which enhances the delivery of the salicylanilide compound to and retention on oral tissue surfaces is optionally incorporated in the composition to improve the efficacy of the salicylanilide compound.

Abstract: A process for enhancing oral hygiene by reducing oral microflora and for inhibiting the formation of dental plaque by applying, to the oral cavity a composition containing (a)0.1 to 40 parts, by weight, of a higher acyl-N-betaine having the structure ##STR1## where R is a higher alkyl group of from 10 to 18 carbon atoms, or mixtures thereof, and (b) 0.

Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain 2-alkylidene aminoguanidines and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Abstract: This invention claims a method for treating periodontal disease in mammals, including humans, by administering an effective amount of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or a pharmaceutically acceptable salt including the monosodium salt tridydrate (alendronate) of the formula: ##STR1## The compounds are useful in the treatment of alveolar bone loss associated with peridontitis and periodontal disease.

Abstract: Copolymers of polyamino acids formed by reaction of polysuccinimide with alkyl, alkenyl, aromatic amines or alkyl and alkenyl polyamines are useful as inhibitors of tartar deposition. Such compounds may be used in conventional dentrifice compositions to prevent tartar deposition on natural or false teeth.

Abstract: An oral composition comprising cetylpyridinium chloride and a N.sup..alpha. -longer acyl basic amino acid lower alkyl ester or a salt thereof. The oral composition of the present invention promotes adsorption of cetylpyridinium chloride as a bactericide to the surfaces of teeth and shows excellent prevention of formation of dental plaque and dental caries.

Abstract: Pneumocystis carinii pneumonia may be prevented in a subject susceptible to infection by Pneumocystis carinii by administering to the subject an amount of a pentamidine in aerosol form effective to prevent infection by Pneumocystis carinii and thus prevent Pneumocystis carinii pneumonia. Also, this invention provides a composition for the prevention of Pneumocystis carinii pneumonia which comprises an amount of a pentamidine effective to prevent infection by Pneumocystis carinii and thus prevent Pneumocystis carinii pneumonia in aerosol form and a pharmaceutically acceptable carrier.

Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) which contain novel amidrazones and derivatives thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Abstract: Polypeptides of the formulapoly (X).sub.m (Y).sub.n,whereinX is selected from the group consisting of aspartate, glutamate, glutamine, asparagine, mixtures and block polymers thereof,Y is selected from the group consisting of phosphoserine, sulfoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, serine, alanine, dehydroalanine and mixtures thereof,m=5-199 andn=1-10have been demonstrated to inhibit mineral deposition, and can be employed in the inhibition of mineral deposition in both in vitro and in vivo applications. Serine-containing polypeptides can be thermally synthesized by combining the necessary amino acid residues in a reaction vessel, eliminating oxygen to preclude charring, and heating said reaction vessel in a heating medium to a temperature of about 155.degree. C.

Abstract: N-alkylamide or D(+)-carnitrine having general formula ##STR1## wherein X.sup.- is OH.sup.- or the anion of a pharmacologically acceptable acid (preferably Cl.sup.-), andR is a straight C.sub.10 -C.sub.16 alkyl radical are prepared via transamination by reacting (D(+)-carnitinamide halogenide with an amine or formula NH.sub.2 R wherein R has the above-identified meaning in an acid environment (e.g. H.sub.3 PO.sub.4) in the presence of a high-boiling solvent (e.g. ethylene glycol).N-alkylamides (I) are endowed with potent anti-bacterial activity and are suitable for preparing pharmaceutical and cosmetic compositions.

Abstract: In accordance with the teachings of this invention, a composition and method for the topical application of a water dispersible active ingredient to a surface of a warm blooded animal is provided. Specifically, such composition is provided to have the properties of being readily flowable upon filling a container therewith, maintaining such flowable condition after storage for a substantial length of time and being readily flowable upon application to the desired animal situs. Uniquely, upon contact with the warm surface of the animal then, and only then, does the composition quickly forms into a non-flowable relatively substantive gel. Specifically such composition comprises:(a) a water soluble non-ionic block copolymer of ethylene oxide and propylene oxide of the formula HO(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b (C.sub.2 G.sub.4 O).sub.c H;(b) the active ingredient to be topically delivered; and(c) water.

Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Abstract: A method of desensitizing a hypersensitive tooth by topically applying to the tooth a composition including an amount of a barbiturate effective to desensitize the tooth. This desensitizing composition may be included in an excipient or in a sustained-release matrix or microbeads that can be incorporated into toothbrushes, dental floss, dentifrices, dental rinses, etc.

Abstract: The propagation of mouse population in a given area of actual or potential mice infestation is prevented as inhibited by treating such area with an effective amount of male mouse sesquiterpenic pheromone or a derivative thereof, wherein such pheromone has male mouse aversion signalling properties, and the pheromone is not used in the form of male mouse urine.