Abstract: Oral hygiene compositions comprising chlorhexidine are described for treating halitosis.

Abstract: The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer forms of compounds of formula La and Ib, wherein R1, R2, R3, R4 and n have the meaning cited in claim 1. Said compounds can be used advantageously in a preparation suitable for oral care.

Abstract: It has been found that a mouthrinse comprising CPC and zinc ions is a very effective mouthrinse. It has an antibacterial effect that removes odor creating bacteria from the oral cavity. The CPC and zinc ions preferably are used in combination with an ionone terpene such as alpha ionone or a beta ionone.

Abstract: An oral hygiene composition comprising chlorhexidine is described which has reduced bitterness.

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.

Abstract: A mouth hygienic composition effective in treating halitosis. The composition comprises a chelate comprising a metal ion, preferably a zinc ion, and an amino acid, preferably glycine.

Abstract: A method of preventing mucositis of mucosal tissues in patients is disclosed which is based on contacting the affected area with an amount of composition which comprises triclosan in amounts which are effective to prevent the symptoms of mucositis.

Abstract: The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

Abstract: Disclosed is a composition for delivering an oral care substance to the oral cavity, comprising: (a) an organosiloxane resin; (b) a volatile carrier capable of solubilizing the organosiloxane resin; (c) a rheology modifier; and (d) at least one oral care substance. The present invention is also directed to such compositions comprising: (a) an organosiloxane resin; (b) a fluid diorganopolysiloxane polymer; (c) a volatile carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane polymer; (d) a rheology modifier; and (e) at least one oral care substance. Further disclosed is a method of using these compositions.

Abstract: A water based liquid tooth cleaning gel is presented with a viscosity below 50 Pa·s (20° C.) comprising 1 10-20% by weight of a silica polish 40-60% by weight of a humectant selected from the group consisting of sorbitol, glycerol, polyethylene glycol and mixtures thereof, 0.01 to 0.2% by weight of magnesium in the form of a dissolved 0.

Abstract: The present invention relates to a product comprising tooth whitening substance which comprises a high concentration of water, a peroxide, a gelling agent, and carrier materials. The tooth whitening substance will remain stable when stored as a thin layer. The present invention also relates to a method of storage of a tooth whitening substance and a method producing a stable thin layer of tooth whitening substance on a strip of material. Additionally, the present invention relates to the benefits obtained from the tooth whitening composition.

Abstract: Periodontic compositions in gel or foam form for treating gum diseases or used in the extraction of teeth, which are alcohol free. The composition is a mixture of a tertiary amine oxide and an antimicrobial betaine compound. The composition is useful for treating gum disease and after the extraction of teeth.

Abstract: The present invention relates to a mouthspray formulation, which reduces oral bacteria and is effective against dental plaque, gingivitis and oral malodor. The preferred formulation has a bactericidal agent with cetyl pyridinium chloride and domiphen bromide, an alcohol, a sweetener component, and a flavor system. The flavor system may also have or more of the following: a flavorant, a humectant, a surfactant, a sweetener, and a colorant agent.

Abstract: There is provided a water-based liquid tooth cleaning gel with a viscosity below 50 Pa·s (20° C.

Abstract: A water based composition having triclosan in an amount of 0.01 to 3% by weight in combination with from 5-35% by weight of a non-toxic polyhydric alcohol and from 0.5-5% by weight of a poloxamer.

Abstract: Novel aqueous slurries capable of removing calculus, plaque or stains, adherent to tooth surfaces of a warm-blooded animal, when used in methods that are self-practicable by an individual human or practicable by an individual human on another warm-blooded animal, combine finely-divided charcoal; water; and alcohol, ammonia or hydrogen peroxide to form the slurries. Also disclosed are self-practicable methods that utilize the disclosed aqueous slurries by applying to, and contacting affected tooth surfaces with, the same, then removing the treated calculus, plaque or stains by means of devices and techniques that are safe to use according to the methods. Further, kits are disclosed that comprise the disclosed aqueous slurries, as well as apparatus, devices and tools for effectively using the same for the above purposes.

Abstract: A method of remineralizing teeth by using an oral hygiene composition comprising a polyvinyl acetal diethylaminoacetate and a fluoride ion-feeding compound; and the composition for use in the method.

Abstract: The present invention provides a calcified tissue facing preparation characterized by having a polymerizable resin, and an antimicrobial agent of formula (I) where R1 is a hydrocarbon radical having between 1 and 16 carbon atoms, n is an integer between 1 and 8 inclusive and X is a halogen atom selected from fluorine, chlorine or bromine. It is appreciated that R1 includes unsaturated hydrocarbon radicals, as well as heteroatom containing radicals. Preferably, the molecule of formula (I) is associated with an adduct species. A solvent and the complementary spectrum antimicrobial benzalkonium chloride are also optionally added. An antimicrobial oral rinse excluding the polymerizable resin contains at least 0.2% by weight of the antimicrobial agent.

Abstract: A water based composition having triclosan in an amount of 0.01 to 3% by weight in combination with from 5-35% by weight of a non-toxic polyhydric alcohol and from 0.5-5% by weight of a poloxamer.

Abstract: The invention relates to a tooth coating composition comprising (A) a polymer having one or more carboxyl or carbonyloxycarbonyl groups in its molecule, a weight average molecular weight of 10,000 to 5,000,000, a solubility of 1 g or higher in 100 g of absolute ethanol at 20° C. and a solubility of 10 g or lower in 100 g of water at 20° C., and (B) water or an alcohol having 1 to 5 carbon atoms. When coating teeth with the composition, the coating is not easily peeled by eating and drinking, but can be easily removed if necessary.

Abstract: This invention concerns a disinfectant composition containing chlorophenyl biguanide and/or chlorobenzyl biguanide compounds and benzoic acid or the salts thereof in an aqueous alcoholic solution and use thereof in the dental field.

Abstract: A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.

Abstract: A toothpaste composition containing an effective amount of cetylpyridinium chloride and a mixture of toothpaste forming ingredients including at least one amphoteric surfactant and optionally at least one sweetener.

Abstract: Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl &bgr;-cyclodextrin, hydroxyethyl &bgr;-cyclodextrin, hydroxypropyl &ggr;-cyclodextrin, hydroxyethyl &ggr;-cyclodextrin, &agr;-cyclodextrin, methyl &bgr;-cyclodextrin, and mixtures thereof. These compositions are useful in retarding the development of plaque, treating gingivitis, and in treating the presence of micro-organisms in the oral cavity.

Abstract: Amine hydrofluorides of the general formula (I): R—N(CH2CH2OH)2.HF   (I) In which R is a straight-chain hydrocarbon residue having 10 to 20 carbon atoms exhibit antibacterial and caries-prophylactic activity and can be prepared in high purity. The amine hydrofluorides of the formula (I) can be formulated, optionally in combination with tin fluoride, into oral hygiene compositions such as toothpastes, mouthwashes or chewable tablets.

Abstract: The invention provides a composition for desorbing bacteria from solid surfaces and from living tissues, which is in the form of a two-phase preparation, and which upon shaking forms a temporary oil-in-water emulsion of limited lifetime, the composition comprising: a) about 50 to about 97% w/w of an aqueous phase; b) about 3 to about 50% w/w of a water immiscible oily phase, comprising a vegetable oil, a mineral oil, a pharmacologically acceptable aliphatic hydrocarbon or a mixture thereof; and c) about 0.003 to about 2.0% w/w of an amphipathic cationic moiety in an effective amount to enable the formation of the temporary oil-in-water emulsion which emulsion breaks down and separates within a period of about 10 seconds to thirty minutes of the formation thereof.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: Devices, coating compositions and methods for making such compositions are provided, wherein the coatings deliver chlorhexidine gluconate from a stable non-aqueous system.

Abstract: A method of cleaning or protecting surfaces by treatment with compositions comprising N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) blocking compounds and/or N-butyryl-L-homoserine lactone (BHL) analogs, either in combination or separately.

Abstract: A dual component antiplaque oral composition having superior foaming properties in which a first component contains a cationic antibacterial agent and the second component contains a anionic surfactant normally incompatible with the cationic antibacterial agent, the first and second components are simultaneously combined for application to the teeth, the first and second components being physically segregated prior to use, the components when mixed upon application to teeth providing substantially unimpaired antiplaque effect with superior foaming properties.

Abstract: An antiplaque mouth rinse conducive to oral hygiene. The mouth rinse composition includes a water-alcohol vehicle having dissolved therein two antibacterial agents that coact to promote the delivery of these agents and their retention on the teeth and soft tissue in the dental region of the oral cavity of the user, thereby inhibiting the formation of plaque. One agent, Triclosan, is water-insoluble and noncationic, a solubilizer therefor being included in the composition. The other agent, cetyl pyridinium chloride (CPC) is soluble in water and alcohol and is cationic. When the combination of Triclosan and CPC is delivered to the dental region, it is adsorbed and retained thereby to afford enhanced antibacterial activity.

Abstract: The invention provides a composition whitening teeth, using a bleaching compound and a catalytic activator, where the catalytic activator catalyzes the reaction of a significant portion of the bleaching compound within in a short period of time. A method for whitening teeth by providing a bleaching compound, providing a catalytic agent, and combining the bleaching agent with the catalytic agent so that a reaction of a significant portion of the bleaching agent occurs in a short period of time is also disclosed. A device for whitening teeth, consisting of a toothbrush where at least one of the bristles contains a catalytic activator is also provided. The handle of this device has a reservoir for a bleaching compound and a means for dispensing the bleaching compound. Another device for whitening teeth, consisting of a toothbrush with a catalytic activator capable of catalyzing the reaction of a bleaching compound applied to the head of the device, is further provided.

Abstract: Oral composition comprises a wintergreen flavor imparting ingredient and having an alkaline pH, wherein the wintergreen flavor imparting ingredient is 2′-hydroxypropiophenone.

Abstract: Anti-plaque emulsions and methods of use are provided. The emulsion comprises a surfactant, emulsifier, and triclosan.

Abstract: Disclosed is a color changing toothpaste which contains color reagents for interacting to provide a color change indicative of tooth brushing time. The color reagents comprise two separate color components which may be an FD&C dye, and FD&C lake or a natural food color, the two separate color components being adapted to interact after a predetermined brushing time to produce a third color. Optionally, the toothpaste may contain up to approximately 0.05% by weight of a foaming agent and other components such as a fluoride and a flavoring agent or flavor burst component.

Abstract: The invention relates to a preparation for use in chemical-mechanical treatment of caries in the form of a two-component caries dissolving liquid in which one of the components consists of sodium hypochlorite and the other component of amino acids, preferably three amino-acids with different charge states; one neutral, one with a negative net charge and one with a positive net charge. A viscosity increasing substance in the form of 3% carboxy methyl cellulose, or any other polysaccharide, as well as a coloring agent, 0.04% Erythrosin, which is able to interact with carious tooth substance has been added to the amino acid component. This means that less liquid is spent, the liquid becomes easier to control and handle and the suspended material becomes more visible.

Abstract: Anti-plaque emulsions and methods of use are provided. The emulsion comprises a surfactant, emulsifier, and triclosan.

Abstract: Compositions for adsorbing sulfur-containing compounds and eliminating or reducing odors associated with the ingestion of foods or medicines causing sulfur odor, such as garlic and onions, contain a metal complex of a substrate and a ligand. The complex may be contained in a carrier, such as a silica gel, and has low solubility in an aqueous environment. The ligand of the compositions may comprise an amino acid containing sulfur, nitrogen, or a carboxylic acid, such as cystine, and the substrate is a metal which may be copper, zinc, or iron.

Abstract: The invention relates to a preparation for use in chemical-mechanical treatment of caries in the form of a two-component caries dissolving liquid in which one of the components consists of sodium hypochlorite and the other component of a substance with the ability to reduce the aggressive influence of sodium hypochlorite on mucous membranes. The other component is a gel component which consists of a gel substance without any amino acids or a gel substance mixed with one or more amino acids.

Abstract: Dental compositions are provided with a fluoride releasing material that is a metal complex described by formula M(G)g(F)n or M(G)g(ZFm)n where M represents an element capable of forming a cationic species and having a valency of 2 or more, G is an organic chelating moiety capable of complexing with the element M Z is hydrogen, boron, nitrogen, phosphorus, sulfur, antimony, arsenic F is a fluoride atom g, m and n are at least 1.

Abstract: The present invention relates to an anti-microbial packaging polymer and its method of use, and more particularly to a contact anti-microbial such as quaternary ammonium and phosphonium salts covalently bound to a polymeric material that may be suitable in a variety of applications such as film and container packaging of foodstuffs, cosmetics, medical equipment and devices, environmental, hygienic and sanitary applications, as well as other consumer and commercial use. This anti-microbial polymer has the benefit of being bactericidal, fungicidal, and/or viricidal. For example, this anti-microbial feature may result in additional shelf life of the foodstuff contained in the anti-microbial packaging polymer of the present invention.

Abstract: An oral composition comprises an antibacterial effective amount of cetylpyridinium chloride, an effective amount of guar hydroxypropyltrimonium chloride, sufficient to bind to compounds which undesirably bind to cetylpyridinium chloride thereby enabling the cetylpyridinium chloride to effectively bind to tooth surfaces and perform an antibacterial function, and an orally acceptable carrier.

Abstract: Oral composition for inhibiting oral malodor, containing an antibacterial agent and a zinc compound, in the form of a mouthwash containing 0.005-0.05% w/v of an antibacterial agent selected from bis-guanides and quaternary ammonium compounds, and 0.05-0.5% w/v of zinc acetate.

Abstract: A flavor composition comprising 8-ocimenyl esters of the formula wherein one of the two radicals R1 and R2 is methyl and the other is vinyl and one of the two radicals R3 and R4 is methyl and the other is wherein R5 is hydrogen, alkyl or alkenyl. Such flavor composition can also be mint and/or fruit flavor compositions, wherein the 8-ocimenyl esters have a flavor-enhancing action.

Abstract: Composition and methods that include potassium nitrate for whitening and/or reducing tooth sensitivity. The dental compositions may optionally include a dental bleaching agent, such as hydrogen peroxide or carbamide peroxide. The dental compositions may be applied directly to the person's teeth, or they may be loaded into a comfortable fitting, flexible, thin-walled dental tray and placed over the person's teeth. In that case, the dental compositions will include a tackifying agent, such as carboxypolymethylene, dispersed within a solvent, which assists the composition in retaining the dental tray over the person's teeth as a result of the adhesive properties of the dental composition rather than due to mechanical interlocking of the tray over the person's teeth. The dental compositions may further include anticariogenic and antimicrobial agents.

Abstract: Composition and methods that include potassium nitrate for whitening and/or reducing tooth sensitivity. The dental compositions may optionally include a dental bleaching agent, such as hydrogen peroxide or carbamide peroxide. The dental compositions may be applied directly to the person's teeth, or they may be loaded into a comfortable fitting, flexible, thin-walled dental tray and placed over the person's teeth. In that case, the dental compositions will include a tackifying agent, such as carboxypolymethylene, which assists the composition in retaining the dental tray over the person's teeth as a result of the adhesive properties of the dental composition rather than due to mechanical interlocking of the tray over the person's teeth. The dental compositions may further include anticariogenic and antimicrobial agents.

Abstract: Pharmaceutical composition comprising as essential ingredients proline, lysine and glycine, suitable for the dental treatment of various periodontal diseases, based upon the local injection of an aqueous solution of the composition itself or on the topical application of its formulations, such as mouth-washes, toothpastes, and gengival gels.

Abstract: Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels.

Abstract: Disclosed herein is a dentifrice composition for imparting good gloss to teeth, comprising wax or shellac. The composition may further contain a fluorinated oil and/or a disinfectant. Examples of the wax include carnauba wax, sugar-cane wax, rice bran wax, hydrogenated rice bran wax, and the like.

Abstract: Amine hydrofluorides of the general formula (I):