Elemental Chlorine Or Elemental Chlorine Releasing Inorganic Compound (e.g., Chlorties, Hypochlorites, Etc.) Patents (Class 424/661)
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Patent number: 6132748Abstract: An important and central aspect of the present invention is the use of expanded amorphous aluminum silicate (EAAS) as a vehicle for a chlorite salt. This vehicle, when exposed to moisture, will release chlorine dioxide (ClO.sub.2) for purposes of deodorization or microbial suppression. Thus, where a particular area or volume is to be deodorized or made less microbally contaminated, the EAAS-chlorite salt (most preferably sodium chlorite) is placed in the area or volume to be treated and moisture is permitted to interact with the material. The result of the moisture is to permit the chemical reaction (presumably acidification) of the chlorite salt to yield chlorine dioxide gas. While normal EAAS has some inherent acidity, the inherent acidity is low enough so that, even when a chloride salt is encapsulated in the EAAS and the resultant mixture exposed to moisture, ClO.sub.2 release is very slow and over an extended period. Under most conditions, a more rapid release of ClO.sub.Type: GrantFiled: February 18, 1999Date of Patent: October 17, 2000Assignee: Bio-Cide International, Inc.Inventors: Neeraj Khanna, Theodore D. Head, Bryan D. Lowery
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Patent number: 6123966Abstract: A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid and an alcohol-containing humectant or antifreeze, while the second part contains a salt of an organic acid and an optional metal chlorite. Methods for making a disinfecting composition by mixing the two-part disinfecting system, as well as for disinfecting substrates by contact therewith, are also disclosed.Type: GrantFiled: September 3, 1998Date of Patent: September 26, 2000Assignee: Alcide CorporationInventor: Robert D. Kross
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Patent number: 6106853Abstract: Processes for controlling pollution by: (a) devolatizing vapor phase chemical pollutants (VP's) found in effluents and other bodies and streams of gases and liquids, and (b) stabilizing substrates from which the VP's are released. The offending VP's are converted to less offensive or inoffensive materials by interaction with an appropriately formulated treating agent (VTA/C) containing a primary halogen and at least one additional ingredient selected from the following classes of constituents (optional if bromine is the primary halogen and otherwise required): oligodynamically active metals, cohalogens, adjuncts, and facilitators. The major constituent(s) may be supplied as such, or a source of the constituent may be provided. Actinic radiation can be employed to promote reactions between the VP and the VTA/C, which is often formulated as an aqueous scrubbing medium.Type: GrantFiled: March 20, 1996Date of Patent: August 22, 2000Inventors: James P. Cox, Robert W. Duffy Cox
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Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
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Patent number: 6099855Abstract: The invention relates to improved methods of raising and treating food animals, which employ pH-buffered, redox-stabilized compositions comprising halide and oxyhalide ions. The compositions can be administered to food animals to effect enhanced food utilization, lower mortality, decreased nitrogen excretion, decreased dependence on antibiotics and vaccines, overall enhanced health and immunostimulation in the animals.Type: GrantFiled: June 21, 1996Date of Patent: August 8, 2000Assignee: Bioxy, Inc.Inventors: Jaime Mullerat, William A. Curby, David A. Hazlett, Peter Kilpatrick
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Patent number: 6096350Abstract: Compositions and methods for disinfecting bee colonies for preventing or treating diseases in honey bees, honey bee larvae and honey bee hives are disclosed. Such diseases may arise from a variety of sources, including bacteria, fungi, viruses, protozoa and parasites in the hive. Representative diseases preventable or treatable by this invention include Foulbrood and Chalkbrood. The compositions of the present invention include a protic acid and a chlorite ion, and may further include other optional components such as a gelling agent, colorant and/or preservative. Methods disclosed herein include applying the composition to a surface of a bee-hive. Honey produced by bees administered a composition of this invention is also disclosed.Type: GrantFiled: September 8, 1995Date of Patent: August 1, 2000Assignee: Alcide CorporationInventors: G. Kere Kemp, Robert D. Kross
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Patent number: 6093423Abstract: A chemical agent for use in binding to and insolubilizing the solubilized products of fat digestion in order to prevent absorption of fat from the diet.Type: GrantFiled: April 25, 1997Date of Patent: July 25, 2000Assignee: Kappa Pharmaceuticals LimitedInventor: Alun Roy Williams
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Patent number: 6077502Abstract: The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.Type: GrantFiled: February 27, 1998Date of Patent: June 20, 2000Assignee: The Procter & Gamble CompanyInventors: Jonathan James Witt, Rohan Lalith Wimalasena, Andrew Lee Wong, Eric Altman Goulbourne, Jr.
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Patent number: 6063425Abstract: A method for disinfecting a meat carcass by spray application of an aqueous solution containing from about 0.05-0.12% of a metal chlorite and a sufficient quantity of an acid having a pK.sub.a of from about 2.0-4.4 to adjust the pH of the aqueous solution to about 2.2-4.5 and to maintain the chlorite ion concentration in the form of chlorous acid to not more than about 35% by weight of the aqueous solution, the molar ratio of the acid to metal chlorite being at least equal to the first pK.sub.a of the acid multiplied by the grams/liter concentration of metal chlorite in the aqueous solution. In one embodiment, the meat carcass is poultry.Type: GrantFiled: October 9, 1997Date of Patent: May 16, 2000Assignee: Alcide CorporationInventors: Robert D. Kross, G. Kere Kemp
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Patent number: 6057488Abstract: A method is provided for destroying a target component, such as hydrocarbons, halogenated hydrocarbons, diethyl-4-nitrophenylphosphate (paraoxon), 2-chloroethyl ethyl sulfide (2-CEES), dimethylmethylphosphonate (DMMP), bacteria such as Bacillus Cereus, Bacillus Globigii, Chlamydia and/or Rickettsiae, fungi and viruses, by contacting the target component with an adsorbent such as MgO, CaO, TiO.sub.2, ZrO.sub.2, FeO, V.sub.2 O.sub.5, V.sub.2 O.sub.3, Mn.sub.2 O.sub.3, Fe.sub.2 O.sub.3, NiO, CuO, Al.sub.2 O.sub.3, ZnO and mixtures thereof wherein the adsorbent contains either reactive atoms selected from the group consisting of halogens and alkali metals stabilized on the surfaces of the adsorbent or ozone and wherein the contacting is conducted at a temperature of -40 to 600.degree. C. for a time period of at least about 4 seconds. The adsorbent may be in the form of solids having a size of about 3 to 20 nanometers or in the form of pellets having a size of at least 1 millimeter.Type: GrantFiled: September 15, 1998Date of Patent: May 2, 2000Assignee: Nantek, Inc.Inventors: Olga Koper, Kenneth J. Klabunde
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Patent number: 6039934Abstract: The invention described relates to gelled chlorine dioxide compositions comprising water, an acid, a water-soluble chlorite salt and a gelling agent in two parts A and B, wherein the gelling agent is xanthan gum or a mixture of xanthan gum and an acid stable gelling agents. Compositions according to the invention are storage stable for at least 6 months, preferably at least about year.Type: GrantFiled: August 4, 1998Date of Patent: March 21, 2000Inventor: Howard Alliger
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Patent number: 6024954Abstract: Compositions for disinfecting contact lenses include a liquid medium containing a chlorite component, preferably a water soluble chlorite component, in a contact lens disinfecting amount, and a polyanionic component, preferably a water soluble polyanionic component, in an amount effective to do at least one of the following: inhibit formation of protein deposit material on a contact lens immersed in the composition; reduce the toxicity of the composition to the human eye, and reduce the damage to a contact lens caused by immersing the contact lens in the composition. The composition has a viscosity of less than 50 cps at 25.degree. C., an osmolality of at least about 200 mOsmol/kg, and preferably a pH in the range of about 6 to about 9.Type: GrantFiled: August 2, 1996Date of Patent: February 15, 2000Assignee: AllerganInventors: John Y. Park, Lin Peng, Daniel P. Cafaro, Anthony J. Dziabo
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Patent number: 6017554Abstract: A stable solution cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonoas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.Type: GrantFiled: September 21, 1998Date of Patent: January 25, 2000Assignee: Micropure, Inc.Inventor: Perry A. Ratcliff
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Patent number: 6008238Abstract: Disclosed is a stable dilute solution composition of a 3-isothiazolone compound selected from the group consisting of 5-chloro-2-methyl-3-isothiazolone, 2-methyl-3-isothiazolone, 5-chloro-2-ethyl-3-isothiazolone, 2-ethyl-3-isothiazolone, 4,5-dichloro-2-methyl-3-isothiazolone, and mixtures thereof in water having extremely low levels of copper ion and an oxidant.Type: GrantFiled: February 13, 1998Date of Patent: December 28, 1999Assignee: Rohm and Haas CompanyInventors: Beverly Jean El A'mma, John Robert Mattox
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Patent number: 6004587Abstract: The invention relates to methods employing pH-buffered, redox-stabilized compositions comprising halide and oxyhalide ions. The compositions can be administered to food animals to effect enhanced food utilization, lower mortality, decreased nitrogen excretion, decreased dependence on antibiotics and vaccines, overall enhanced health and immunostimulation in the animals. Additionally, the compositions can be used to treat food animal carcasses to reduce foodborne pathogens and spoilage organisms.Type: GrantFiled: October 28, 1998Date of Patent: December 21, 1999Assignee: Bioxy Inc.Inventors: Jaime Mullerat, David A. Hazlett, William A. Curby, Peter Kilpatrick
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Patent number: 5997911Abstract: A composition and method for reducing the incidence of Poult Enteritis Mortality Syndrome in young turkeys, flushing in mature turkeys, and scours in swine. The composition of the present invention comprises, in combination, a simple copper (II) salt, a hydroxycarboxylic acid, and a buffering agent solubilized within the drinking water of turkeys and/or swine in an antidiarrheal effective dosage as preventative maintenance in avoiding the diarrheal conditions associated with PEMS, flushing, and scours. In a preferred embodiment, the simple copper (II) salt comprises copper sulfate pentahydrate, the hydroxycarboxylic acid comprises anhydrous citric acid, and the buffering, agent comprises ammonium carbonate.Type: GrantFiled: August 27, 1996Date of Patent: December 7, 1999Assignee: Brinton Veterinary Supply, Inc.Inventors: Gene Brinton, Jackie Brinton Mourning
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Patent number: 5993864Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.Type: GrantFiled: July 11, 1997Date of Patent: November 30, 1999Inventor: Robert D. Kross
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Patent number: 5989497Abstract: A process and apparatus are provided for deodorizing malodorous solids, liquids, and/or gases by contacting them with a mist of an aqueous deodorizing solution consisting of an alkali metal or alkaline earth metal chlorite, buffering agent(s), water, and optionally an alkali metal or alkaline earth metal chlorate and/or an alkali metal alkaline earth metal chloride. The preferred alkali metal is sodium. The deodorizing solution contains available chlorine dioxide and has a pH of about 8.5-9.5. In the process a concentrated solution of the deodorizing solution is diluted and mixed with water and misted into or onto the substance(s) to be deodorized, for example, the sewer gases from a sewage lift station. The apparatus consists of a rotameter which measures the amount of the concentrated deodorizing solution introduced into an eductor for dilution in a passing water stream which is then transported to spray nozzles for misting the malodorous substance(s).Type: GrantFiled: July 31, 1997Date of Patent: November 23, 1999Inventor: Roland R. Labonte, Jr.
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Patent number: 5985302Abstract: Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.Type: GrantFiled: July 10, 1998Date of Patent: November 16, 1999Assignee: Supergen, Inc.Inventors: Robert T. Dorr, David S. Alberts
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Patent number: 5976509Abstract: A liquid composition for use as an odontostomatological aid comprises a water solution of suitable amounts of calcium hypochlorite and potassium chloride. The composition is valuable in therapy owing to its many properties as disinfectant, lubricant, stabilizer, enzyme activator, immunosuppressor, analgesic and haemostatic agent.Type: GrantFiled: May 26, 1998Date of Patent: November 2, 1999Inventors: Thomas Abbondi, Marco Rotondi, Alfredo Capellino
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Patent number: 5955486Abstract: Stable microbicidal compositions containing a 3-isothiazolone compound, chlorate or perchlorate salts, copper salts and water are disclosed. Also disclosed are methods of preventing or reducing precipitate formation in 3-isothiazolone compositions.Type: GrantFiled: February 13, 1998Date of Patent: September 21, 1999Assignee: Rohm and Haas CompanyInventor: John Robert Mattox
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Patent number: 5948315Abstract: A sunlight-ultraviolet-stable biocide composition for use in treating recreational and industrial water systems is disclosed which comprises an oxidizing halogen compound and a stabilizer, wherein the stabilizer is either benzenesulfonamide or a derivative thereof.Type: GrantFiled: April 14, 1998Date of Patent: September 7, 1999Assignee: Nalco Chemical CompanyInventors: Shunong Yang, William F. McCoy
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Patent number: 5945449Abstract: A sterile bicarbonate concentrate for use in the present invention relates to a sterile calcium-free bicarbonate concentrate for use in peritoneal dialysis, hemofiltration, cardiac bypass surgery and in electrolyte replacement therapy.Type: GrantFiled: October 31, 1997Date of Patent: August 31, 1999Assignee: Dialysis Solutions Inc.Inventors: Larry Joseph Purcell, Sheldon William Tobe
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Patent number: 5935592Abstract: A stable solution, cream, salve, or spray composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the treatment of vaginitis and endometriosis by reducing any of Candida, Actinobacillus actinomycetemcomitans, Pseudomonades, and Porphyromonas gingivalis present in the vagina or the uterus. The preferred concentration ranges are in the range of about 0.005% to about 2.0% of chlorine dioxide, and in the range of about 0.02% to about 3.0% of phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.Type: GrantFiled: May 6, 1998Date of Patent: August 10, 1999Assignee: Micropure, Inc.Inventor: Perry A. Ratcliff
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Method for treating the epithelium of bodily orifices with chlorine dioxide and a phosphate compound
Patent number: 5902575Abstract: A stable solution, cream, salve, or spray composition containing chlorine dioxide and a phosphate, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices brought about by any of leukoplakia, hairy leukoplakia, vaginitis, endometriosis, Candida Albicans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Pseudomonades, Candida species, and leukoplakia vulvae. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.Type: GrantFiled: April 27, 1998Date of Patent: May 11, 1999Assignee: Micropure, Inc.Inventor: Perry A. Ratcliff -
Patent number: 5855922Abstract: Compositions and processes for the prophylaxis and therapeutic treatment of wounds, chronic non-healing wounds, burns, disease and other dermal disorders are disclosed. The compositions of the present invention comprise aqueous solutions of a metal chlorite having a concentration of from about 0.002% to about 0.5% by weight of metal chlorite. The process of the present invention comprises treating the dermal disorder with an aqueous solution of from about 0.002% to about 0.5% by weight of a metal chlorite. Wounds, chronic non-healing wounds, burns and other dermal disorders treated in this manner heal more quickly and with reduced scar formation. The antiseptic compositions and processes of the present invention exhibit anticollagenous activity such that the characteristics of the healed skin, such as elasticity and tensile strength, are similar to undamaged skin.Type: GrantFiled: December 7, 1995Date of Patent: January 5, 1999Assignee: Bio-Cide International, Inc.Inventors: Bobby C. Danner, Hampar L. Karageozian, James P. Ringo
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Patent number: 5834003Abstract: A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices to maintain the epithelial barrier and reduce penetration of any of Candida, Actinobacillus actinomycetumcomitans, Pseudomonades, and Porphyromonas gingivalis, said method comprising the step of applying to the orifices a composition comprising a topical preparation selected from the group consisting of liquid solutions, suspensions, semi-solids, salves, creams, and suppositories, wherein the topical preparation contains chlorine dioxide in a concentration in the range of about 0.005% to about 2.0% and a phosphate compound selected from the group consisting of disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodiuit phosphate, or sodium monofluorophosphate in a concentration in the range of about 0.02% to about 3.Type: GrantFiled: April 2, 1997Date of Patent: November 10, 1998Assignee: Micropure, Inc.Inventor: Perry A. Ratcliff
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Patent number: 5830511Abstract: The invention relates to methods employing pH-buffered, redox-stabilized compositions comprising halide and oxyhalide ions. The compositions can be administered to food animals to effect enhanced food utilization, lower mortality, decreased nitrogen excretion, decreased dependence on antibiotics and vaccines, overall enhanced health and immunostimulation in the animals. Additionally, the compositions can be used to treat food animal carcasses to reduce foodborne pathogens and spoilage organisms.Type: GrantFiled: December 23, 1994Date of Patent: November 3, 1998Assignee: Bioxy Inc.Inventors: Jaime Mullerat, David A. Hazlett, William A. Curby, Peter Kilpatrick
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Patent number: 5814346Abstract: The compound, in use, is sprinkled over the excrement for treatment to neutralize and eliminate the odour, spores, fungi, bacteria and microorganisms therein, and presents a first subcompound in powder comprising a mixture of diatoms (often referred to as infusorial earth), a calcium-based substance and a sulphur-based substance.Type: GrantFiled: June 6, 1996Date of Patent: September 29, 1998Assignee: Progetto Emme S.r.l.Inventor: Bruno Gamberini
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Patent number: 5811113Abstract: Methods, compositions and a kit for deactivating spills or leaks of HIV infected blood or anticancer drugs by applying to the leak or spill an aqueous solution containing calcium hypochlorite or sodium hypochlorite as the active ingredient. In order to thicken the aqueous solution and thus keep it from spreading beyond its intended area of application, the solution of calcium hypochlorite contains methylcellulose. In addition to chemically deactivating the active anticancer drug, the solution of the invention also effectively decolorizes it, thus preventing permanent stains on any surface or fabric with which the anticancer drug comes into contact.Type: GrantFiled: November 6, 1992Date of Patent: September 22, 1998Assignee: Cancer Technologies, Inc.Inventors: Robert T. Dorr, David S. Alberts
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Patent number: 5811115Abstract: A stable solution, cream, salve, or spray composition containing chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are in the range of about 0.005% to about 2.0% chlorine dioxide, and in the range of about 0.02% to about 3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of about 6.0 to about 7.Type: GrantFiled: April 2, 1997Date of Patent: September 22, 1998Assignee: Micropure, Inc.Inventor: Perry A. Ratcliff
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Patent number: 5772985Abstract: Compositions and methods for the treatment of mammalian skin lesions are provided. The compositions contain a protic acid and a chlorite ion, and may be applied topically to a lesion to promote healing. The compositions and methods are particularly useful in the dairy industry for the treatment of bovine hairy heel warts.Type: GrantFiled: September 8, 1995Date of Patent: June 30, 1998Assignee: Alcide CorporationInventors: G. Kere Kemp, Robert D. Kross
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Patent number: 5753217Abstract: A method of reducing oral malodor includes providing a solution of sodium chlorite and a metal ion capable of complexing with sulfur and applying the solution as mouth rinse.Type: GrantFiled: August 14, 1996Date of Patent: May 19, 1998Assignees: William C. Christopfel, M. E. SaremiInventor: William C. Christopfel
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Patent number: 5738840Abstract: An aqueous composition for the treatment and prevention of malodor of the oral cavity has molecular chlorine dioxide at a concentration of about 1 ppm to about 200 ppm and a pH in the range of about 5.0 to about 7.5. The oral rinse may be used as part of a specific regimen of professional care and/or home use. The oral rinse may be prepared by mixing sodium hypochlorite or other chlorine-releasing agent with sodium chlorite. A convenient kit for preparing the oral rinse treatment contains aqueous sodium chlorite and aqueous sodium hypochlorite in buffered solutions.Type: GrantFiled: February 14, 1997Date of Patent: April 14, 1998Assignee: Profresh Properties, Inc.Inventor: Jon L. Richter
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Patent number: 5736165Abstract: Disclosed are in-the-eye uses of chlorine dioxide-containing compositions as effective ophthalmic antiseptics and as effective ophthalmic surgical irrigants. Surprisingly low concentrations of chlorine dioxide are effective in such applications. In addition, the presently useful compositions are ophthalmically acceptable.Type: GrantFiled: July 20, 1994Date of Patent: April 7, 1998Assignee: AllerganInventors: Paul S. Ripley, Anthony J. Dziabo, Claude B. Anger
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Patent number: 5731008Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections contains an electrolyzed saline containing regulated amounts of ozone and active chlorine species wherein the ozone content is between about 5 and 100 mg/L and the active chlorine species content of between about 5 and 300 ppm. The active chlorine species contains free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the desired active ingredients. The solution is preferably utilized at an isotonic saline concentration and may be adjusted with hypertonic saline. The solution may be used for the in vitro treatment of infected whole blood, blood cells or plasma to reduce contamination and is effective in treatment of fluids infected with HIV, hepatitis and other viral, bacterial and fungal agents.Type: GrantFiled: August 30, 1996Date of Patent: March 24, 1998Assignee: Medical Discoveries, Inc.Inventor: Robert E. Morrow
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Patent number: 5707739Abstract: A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.Type: GrantFiled: June 5, 1995Date of Patent: January 13, 1998Assignee: Southwest Research InstituteInventors: Stephen T. Wellinghoff, Joel J. Kampa, Darren E. Barlow
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Patent number: 5688515Abstract: Disclosed is a water stable tablet for disinfecting recirculating water systems comprising chlorinated isocyanurate, sodium bromide and a stabilizer which regulates the rate at the chlorinated isocyanurate and the sodium bromide are dissolved or dispersed in flowing water. The stabilizer may be an active chlorine stabilizer compound that is compatible with chlorinated isocyanurates in the solid state, capable of binding active halogen (chlorine or bromine in the +1 valence state), and less soluble when fully chlorinated than in the less than chlorinated state.Type: GrantFiled: December 21, 1994Date of Patent: November 18, 1997Assignee: Occidental Chemical CorporationInventors: Thomas C. Kuechler, Lawrence F. Rakestraw
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Patent number: 5679378Abstract: The invention is directed to Dead Sea mud for restoration of hair growth and retardation of hair loss for those suffering from alopecia and a hair therapy method of topically applying to the scalp of a human or other mammal scalp an effective amount of the Dead Sea mud. Dramatic results in overall hair therapy have been obtained by those individuals that have practiced the present method for a relatively short period of time.Type: GrantFiled: November 18, 1996Date of Patent: October 21, 1997Assignee: Olim Industries of Israel, North America, Ltd.Inventor: Raymond Robert Fischer
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Patent number: 5674537Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections containing an electrolyzed saline solution having a content of regulated amounts of ozone and active chlorine species. The ozone content is 5 to 100 mg/L (milligram per liter) and the chlorine species content is 5 to 300 parts per million (ppm). The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the active ingredients. The solution is used at an isotonic saline concentration and my be adjusted with hypertonic saline. The solution is used in vitro treatments of infected whole blood, blood cells or plasma to reduce contamination. The solution may also be administered to warm blooded animals, including humans by intravenous injection.Type: GrantFiled: June 7, 1995Date of Patent: October 7, 1997Assignee: Medical Discoveries, Inc.Inventor: Robert E. Morrow
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Patent number: 5670059Abstract: A novel method and compositions are disclosed for the treatment of water in recirculating water systems. The method includes providing a boron level of at least 20 ppm in the water, continually eroding into the water a compressed sanitizer/algicide component including a halogen source material, a boron source material, and glycoluril, and periodically adding to the water an oxidizing clarifier comprising a chlorine source material, a non-halogen, chlorine source material, and a boron source material. The invention also provides novel water treatment chemicals including the compressed sanitizer/algicide component and the clarifier useful in the foregoing system. The system and compositions are safe and reliable, control algal and fungal growth and generally provide improved water quality for recirculating water systems.Type: GrantFiled: September 20, 1995Date of Patent: September 23, 1997Assignee: Bio-Lab, Inc.Inventors: Ronald L. Jones, Stephen L. Carlyle, Susan M. Shelor, Presley K. Mitchell, Ellwood LeRoy Lines, Jr.
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Patent number: 5667817Abstract: Methods for preventing and treating microbial infections in the mammalian female lower genital tract such as vulvitis, vaginitis, cervicitis, and endometritis involve the intra-vaginal and/or intra-uterine infusion of a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions exhibit a pH compatible with the lower genital tract, e.g., a pH from about 5 to about 7.5. In many embodiments, chlorine dioxide in the solution is produced by reacting a chlorite with a mineral acid and adjusting the pH, by reacting a chlorite with an organic acid having a pK of about 2.8 to 4.2, or by reacting a chlorite at a pH below about 5.5 with a heat-activated saccharide in the presence of an organic acid having a pK of about 2.8 to about 4.2. Sodium chlorite is employed in preferred embodiments.Type: GrantFiled: August 28, 1996Date of Patent: September 16, 1997Assignee: Alcide CorporationInventor: Robert D. Kross
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Patent number: 5662940Abstract: Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20.Type: GrantFiled: June 7, 1995Date of Patent: September 2, 1997Assignee: University of HoustonInventors: Terry V. T. Hight, Jack V. Matson, Lawrence F. Rakestraw, Zhihe Zhang, Thomas C. Kuechler
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Patent number: 5651996Abstract: The present invention relates to a method for producing chlorine dioxide (ClO.sub.2) disinfecting solution which preferably minimizes the amount of residual chlorite ion (ClO.sub.2 --) so that the disinfecting solution can be used in a number of industries, preferably including the food, food processing, drinking water, pharmaceutical production, medical and dental industries. Chlorine dioxide generating solutions which are substantially corrosion free as well as gel formulations are also disclosed.Type: GrantFiled: December 19, 1994Date of Patent: July 29, 1997Assignee: ARCO Research Co., Inc.Inventor: Habib Roozdar
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Patent number: 5648314Abstract: A slow-dissolving sanitizing and clarifying puck for use in water such as swimming pool water preferably includes about 63% to about 80% trichloro-s-triazinetrione, about 4% to about 12% sodium tetraborate, about 10% to about 22% aluminum sulfate, and about 1% to 5% glycoluril.Type: GrantFiled: May 15, 1995Date of Patent: July 15, 1997Assignee: Bio-Lab, Inc.Inventors: Thomas M. Lachocki, Oscar T. Ragin, Presley K. Mitchell
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Patent number: 5648074Abstract: Compositions and methods for disinfecting contact lenses are disclosed. In one embodiment, the present compositions include a liquid medium containing chlorine dioxide precursor in an amount effective to form, when activated, a chlorine dioxide-containing composition including a contact lens disinfecting amount of chlorine dioxide. A polyanionic component, preferably a water soluble polyanionic component, is included in the composition in an amount effective to inhibit the formation of proteinaceous deposit material on a contact lens immersed in the chlorine dioxide-containing composition. Thus, effective contact lens disinfection is achieved while, at the same time, reducing the risk of forming proteinaceous deposit material on the contact lens during the disinfecting processing.Type: GrantFiled: December 12, 1994Date of Patent: July 15, 1997Assignee: AllerganInventors: John Y. Park, Lin Peng, Anthony J. Dziabo
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Patent number: 5641520Abstract: A method for providing aqueous solutions of HOBr or HOCl which includes adding bleach (NaOCl) to a solution of HBr or HCl an identified absorbance or color change in the resulting solution is detected. Dialkylhydantoins are optionally added to the resulting solution to suppress the formation of halate ions. The method provides a simple and reliable method for producing accurately defined solutions of hypohalous acids, which are useful in a variety of ways, including for disinfecting, cleaning, and odor control purposes.Type: GrantFiled: June 7, 1995Date of Patent: June 24, 1997Assignee: Great Lakes Chemical CorporationInventors: Jonathan N. Howarth, Enrico J. Termine, Alan M. Yeoman
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Patent number: 5639295Abstract: A process for preparing a composite which provides sustained release of chlorine dioxide which includes mixing a hydrophilic material containing an amine and a base with a hydrophobic material containing an acid releasing agent, the hydrophilic and hydrophobic materials being adjacent and substantially free of water, to form a mixture. The mixture is exposed to chlorine dioxide which reacts with the amine to form iminium chlorite which is decomposed by the base to form a chlorite salt within the hydrophilic material. The hydrophilic material is capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.Type: GrantFiled: October 3, 1996Date of Patent: June 17, 1997Assignee: Southwest Research InstituteInventors: Stephen T. Wellinghoff, Joel J. Kampa
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Patent number: 5637497Abstract: A lens storage container having an interior coated with an enzymatic cleaning composition useful for cleaning and disinfecting contact lenses.Type: GrantFiled: June 28, 1995Date of Patent: June 10, 1997Assignee: Alcon Laboratories, Inc.Inventor: Ralph P. Stone
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Patent number: 5624636Abstract: The invention is directed to improving the disinfection of dental impressions following removal from the patient's mouth and before entering the dental laboratory to prevent contamination. It involves the use of a pH-adjusted hypochlorite solution, which is highly effective in killing microorganisms, and also relatively inexpensive. Using the solution of the instant invention for disinfection causes no damage to the impression, no loss of accuracy, and does not destroy the details on the impression surface.Type: GrantFiled: November 7, 1994Date of Patent: April 29, 1997Assignee: Univ. of Texas Board of RegentsInventor: Richard S. Schwartz