Abstract: An improved antimicrobial composition is described as a liquid concentrate. The liquid concentrate includes a complex resulting from an in-situ reaction of a cation source, an oxidant, a halide source having at least one iodine atom, and a non-mineral acid, or a mixture of a non-mineral acid to about 50% of a hydrophilic solvent by volume.

Abstract: Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression are measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.

Abstract: The present invention is directed to frozen biocidal compositions. Specifically, the biocidal compositions comprise a frozen aqueous solution of a plurality of ions selected from the group consisting of halide and oxyhalide ions. The frozen biocidal compositions are useful in preserving or extending the shelf-life of perishable articles.

Abstract: An animal model for inflammatory bowel disease is described. The model is based on a mammal not expressing a functional mdr1a gene product, or wherein the mdr1a gene product is inhibited, which develops inflammatory bowel disease when subjected to elevated chlorine concentrations, e.g. given chlorinated drinking water. Methods of screening for compounds useful for the treatment of inflammatory bowel disease, as well as methods to identify, for example, new targets for new compounds for the treatment of inflammatory bowel disease are also described.

Abstract: Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

Abstract: Ophthalmic compositions include a carrier component, an oxy-chloro component present at an amount effective in preserving the composition, and at least one additional component, e.g. a borate component and/or a glycerin component present in an amount effective to enhance a preservative efficacy of the composition. The compositions preferably also include one or more other components, such as therapeutic components, e.g., quinoxaline components, and polyanionic components effective to provide the compositions with one or more functionalities.

Abstract: The present invention provides a bactericide composition comprising hypochlorous acid or a salt thereof. In particular, the present invention provides a liquid bactericide composition comprising an aqueous solution comprising hypochlorous acid and/or a salt thereof, a surfactant (B) and a pH adjusting agent (C), and having a ph valve in the range of 3 to 8 at 25° C.

Abstract: Compositions including a liquid medium, a cyclodextrin component and a preservative component which has a reduced tendency to being complexed with the cyclodextrin component. In one embodiment, the preservative component is a chlorite component. Active components, such as pharmaceutically active components or drugs, preferably are included in the compositions.

Abstract: A gel rehydration electrolyte composition provides a convenient and effective way of replenishing lost fluid and electrolytes. The gel rehydration electrolyte composition masks unpleasant tastes of electrolyte and is readily consumed by young children and elderly who cannot tolerate the liquid or frozen forms of electrolytes.

Abstract: A sodium chlorite solution is admixed with a second solution containing an acid to make a reacted mixture. The reacted mixture is introduced into a water system, viz. a conduit in which water flows or a tank containing water. The reacted mixture is added to the water system to inhibit and/or eliminate bacterial fouling in the system, and/or inhibiting and/or removing mineral deposits from the system, and/or for reducing or eliminating microorganisms from the system. The second component is acidic enough to convert the sodium chlorite into chlorine dioxide while remaining unaffected in the reacted mixture and at the same time being a mineral antiscalant. Optimum conversion of the sodium chlorite component into active chlorine dioxide requires at least several minutes reaction time and, preferably, the use of a suitable catalyst, such as sodium molybdate.

Abstract: Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride.

Abstract: The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of the compound Xm(ClO3)n, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia species.

Abstract: The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.

Abstract: The present invention relates to compositions for water treatment based on biodegradable polymers containing repeating succinyl units, biocidal oxidizing agents and unsubstituted or substituted amidosulphonic acid, their use in, and the process for, conditioning water of cooling circuits.

Abstract: Methods of treating tumors, lesions, and cancers comprising delivering to the affected site a combination of peroxide and hypochlorite anion. Hydrogen peroxide and sodium hypochlorite are possible sources of peroxide and hypochlorite anion, respectively. The reactants may be injected simultaneously or sequentially, and combine at the site to produce singlet oxygen. Singlet oxygen may be delivered to the treatment site or generated at the treatment site. Isotopes are also synergistically used in conjunction with singlet oxygen. The isotopes may be radioactive isotopes, non-radioactive isotopes, or both.

Abstract: The invention provides for a nasal spray which is an aqueous solution containing a broad spectrum microbicide which may be applied in nasal passages in the manner of a decongestant type nose spray in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents. The solution contains active agents which are based on a chlorine or hypochlorite solution, or a solution of chlorine or hypochlorite plus a salt of chloride, bromide or iodide. Alternatively, the solution may contain a bromine solution, or a solution of bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide. The chlorine, hypochlorite, bromine, chloride, bromide, and iodide may originally come from inorganic compounds or organic compounds, which are then dissolved in the water. Further, the solution may contain glycerin or another moisturizing or wetting agent for the nasal mucosa.

Abstract: The invention relates to a process for the synthesis of monochloramine by reaction of an ammonium chloride solution with a sodium hypochlorite solution. The sodium hypochlorite solution is basified beforehand with an inorganic base and the ratio of the concentration of ammonium chloride in the reaction medium to the concentration of sodium hypochlorite in the reaction medium is between 1 and 1.5. This ratio is preferably equal to 1.1.

Abstract: Compositions including a liquid medium, a cyclodextrin component and a preservative component which has a reduced tendency to being complexed with the cyclodextrin component. In one embodiment, the preservative component is a chlorite component. Active components, such as pharmaceutically active components or drugs, preferably are included in the compositions.

Abstract: A method is disclosed of practicing nasal hygiene comprising the steps of applying to a person's nostril a non-irritating hygienic composition consisting essentially of a product of compounding under homogenizing conditions water, 0.01% to 5% by weight, as chlorine dioxide, of a source of chlorine dioxide; 0.01% to 3% by weight of at least one olfactory stimulant, 0 to 5% by weight of at least one fixative compound less volatile than the olfactory stimulant 0.1 to 2.5% by weight of at least one inorganic salt selected from the group consisting of alkali metal chloride, alkali metal bicarbonate, and alkali metal chlorate; and 0.0002 to 0.006% (as aluminum) by weight of at least one water soluble aluminum compound, provided that the total concentration of inorganic salt is in the range from 0.6% by weight to 2.5% by weight, holding the composition within the nostril for a hygienic holding period, and discharging the composition from the treated nostril.

Abstract: A new, novel and useful disinfection and purification system comprised of organic compounds in synergistic action with selected metal ions and method of manufacture and use. One of the benefits that is derived from this system is the ability to quickly and easily treat a surface, fluid or medium for disinfection of bacteria, fungi, viruses, algae and protozoans, with a non-toxic, non-chlorinated mixture that effectively kills all such organisms in minutes or hours. The disinfection and purification system remains effective for long periods of time maintaining its disinfection capacity making it highly effective for stored or transported mediums such as potable drinking water. The disinfection and purification system may be incorporated with carbon block or membrane filters to disinfect filtered liquids such as water to render it potable.

Abstract: Raw water is treated with chlorine, chlorine dioxide and ammonia in various stages as it proceeds from raw water acquisition through clarification (e.g., coagulation, flocculation, sedimentation, and filtration) to storage of finished water from which the treated water can be introduced into a distribution system. Chlorine dioxide can be used as a pre-oxidant or disinfectant. Chlorine can be used as a disinfectant or to react with ammonia to produce monochloramine.

Abstract: Composition of Hypochlorous acid characterized because it has the following chemical composition

Abstract: A biocide composition is formed from a peroxide and a hypochlorite, wherein the biocide composition is formed by adding the peroxide to the hypochlorite in an amount so that the weight ratio of the hypochlorite to the peroxide is no less than about 10:1. A method of producing a biocide composition is carried out by charging to a vessel a quantity of a hypochlorite, and then adding to the hypochlorite so charged a quantity of a peroxide, the weight ratio of the hypochlorite so charged to the peroxide added thereto being no less than about 10:1. A related method is practiced by applying a biocidally effective amount of the biocide composition of the invention to a surface to be decontaminated.

Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.

Abstract: An anti-microbial composition for providing a therapeutic application onto a living being. The composition includes from about 0.001 wt. % to about 0.20 wt. % chlorite compound and from about 0.001 wt. % to about 0.05 wt. % peroxy compound. The anti-microbial composition of the present invention is composed to remain intact without being degraded to generate chlorine dioxide during storage at about a room temperature. The anti-microbial composition of the present invention is at a pH range between about 6.0 and about 8.8.

Abstract: The present invention relates to antimicrobial compositions including a critical, near critical, or supercritical (densified) fluid and an antimicrobial agent, to methods of forming these compositions, and to methods employing these compositions. An antimicrobial agent can be generated in the presence of a densified fluid, for example, by reacting an oxidizing agent with a precursor to the antimicrobial agent.

Abstract: The invention concerns pharmaceutical composition including (i) at least a halogenated compound and (ii) at least N-halogenated derivative of at least a compound selected from zwitterionic compounds and/or amino acids. The halogenated compound is advantageously an alkaline metal hypochlorite, and preferably sodium hypochlorite, and N-halogenated derivative is preferably an N-halogenated taurine derivative and particularly a taurine N-haloamine derivative and even more preferably taurine N-chloramine. The invention also concerns the preparation of the compositions and their uses as very large spectrum antiseptic, anti-inflammatory agent and as immunity modulator, without stimulating myeloperoxidase activity.

Abstract: A polymeric body covering article that generates and releases gas upon activation by electromagnetic energy and/or moisture. The gas provides antimicrobial and/or antiodor protection to objects in contact or in proximity to the interior surface of the article and/or to objects in contact or in proximity to the exterior surface of the article.

Abstract: The present invention relates to a biocidal composition, designed for the generation of chlorine dioxide, comprising at least one iodo-compound having at least one iodine atom and a source of chlorite ions. The molar ration of chlorite ions to iodine atoms is 2 or greater. The composition finds use in a variety of applications including methods of cleaning, sanitizing, deodorizing, and disinfecting various surfaces.

Abstract: The invention provides for a nasal spray which is an aqueous solution containing a broad spectrum microbicide which may be applied in nasal passages in the manner of a decongestant type nose spray in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents. The solution contains active agents which are based on a chlorine or hypochlorite solution, or a solution of chlorine or hypochlorite plus a salt of chloride, bromide or iodide. Alternatively, the solution may contain a bromine solution, or a solution of bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide. The chlorine, hypochlorite, bromine, chloride, bromide, and iodide may originally come from inorganic compounds or organic compounds, which are then dissolved in the water. Further, the solution may contain glycerin or another moisturizing or wetting agent for the nasal mucosa.

Abstract: The present invention is directed to a composition for inhibiting microbial growth, which includes a biocide (other than a triamine) and a triamine. The biocide is an oxidizing biocide, a non-oxidizing biocide, or a combination thereof. This composition is particularly effective at preventing the growth of various microorganisms in aqueous solutions, such as industrial waters. The present invention also relates to a method of controlling the growth of microorganisms in an aqueous composition by adding the composition of the present invention to the solution.

Abstract: Expanded amorphous aluminum silicate (EAAS) is used as a vehicle for a chlorite salt. This vehicle, when exposed to moisture, will release chlorine dioxide (ClO2) for purposes of deodorization or microbial suppression. Thus, where a particular area or volume is to be deodorized or made less microbially contaminated, the EAAS-chlorite salt (most preferably sodium chlorite) is placed in the area or volume to be treated and moisture is permitted to interact with the material. The result of the moisture is to permit the chemical reaction (presumably acidification) of the chlorite salt to yield dioxide gas. While normal EAAS has some inherent acidity, the inherent acidity is low enough so that, even when a chloride salt is encapsulated in the EAAS and the resultant mixture exposed to moisture, ClO2 release is very slow and over an extended period.

Abstract: The present invention relates to a composition for the treatment of acne comprising chlorine dioxide or chlorine dioxide generating compounds as acne reduction agents. The invention also relates to a method for treating acne by topically administering one of the compositions in an amount therapeutically effective to reduce the redness and blemishes associated with acne.

Abstract: Compositions and methods for destroying biological agents such as toxins and bacteria are provided wherein the substance to be destroyed is contacted with finely divided metal oxide or hydroxide nanocrystals. In various embodiments, the metal oxide or metal hydroxide nanocrystals have reactive atoms stabilized on their surfaces, species adsorbed on their surfaces, or are coated with a second metal oxide. The desired metal oxide or metal hydroxide nanocrystals can be pressed into pellets for use when a powder is not feasible. Preferred metal oxides for the methods include MgO, SrO, BaO, CaO, TiO2, ZrO2, FeO, V2O3, V2O5, Mn2O3, Fe2O3, NiO, CuO, Al2O3, SiO2, ZnO, Ag2O, [Ce(NO3)3—Cu(NO3)2]TiO2, Mg(OH)2, Ca(OH)2, Al(OH)3, Sr(OH)2, Ba(OH)2, Fe(OH)3, Cu(OH)3, Ni(OH)2, Co(OH)2, Zn(OH)2, AgOH, and mixtures thereof.

Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.

Abstract: The present compositions advantageously treat hyperemia with substantially no added irritation to the eye. In one embodiment, the compositions include an ophthalmically acceptable carrier component, a vasoconstrictor component in an amount effective to treat hyperemia when the composition is administered to an eye, and a polyanionic component in an amount effective to provide lubrication to an eye when the compositions are administered to the eye.

Abstract: The present invention provides an antimicrobial composition. The composition comprises a cell-permeabilising agent and at least one compound of general formula (I) wherein R1 and R2 are independently H, halogen, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more heteroatoms, straight chain or branched chain, hydrophilic fluorophilic; R3 and R4 are independently H, halogen, alkyl, aryl or arylalkyl, alkoxy; R3 or R4+R2 can be saturated or an unsaturated cycloalkane; and “” represents a single bond or a double bond provided that at least one of R1, R2, R3 and R4 is a halogen.

Abstract: Peptide compositions and methods for inhibiting and controlling the growth of microbes using peptides possessing antimicrobial activity are described. The composition comprises at least one antimicrobial peptide in combination with at least one biocide, germicide, preservative or antibiotic. The method comprises administering an amount of the peptide composition effective for the prevention, inhibition or termination of microbes in industrial and clinical settings.

Abstract: An improved antimicrobial composition is described as a liquid concentrate. The liquid concentrate includes a complex resulting from an in-situ reaction of a cation source, an oxidant, a halide source having at least one iodine atom, and a non-mineral acid, or a mixture of a non-mineral acid to about 50% of a hydrophilic solvent by volume.

Abstract: Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride.

Abstract: The invention pertains to a device for generating aqueous chlorine dioxide solutions when the device is contacted with liquid water. The device comprises an alkali metal or alkaine earth metal chlorite, e.g, sodium chlorite, and a chemical reagent comprising an acid or a material capable of releasing an acid upon exposure to liquid water, e.g., sodium bisulfate. The chlorite and the reagent are either combined as a mixture or are disposed as separate components adhered to the surface of one or more substrates. Upon exposure to liquid water, the chlorite and the reagent produce boundary layers. The chlorite and the reagent are disposed upon, and adhered to, the surface(s) of the substrates in a manner such that upon exposure to liquid water, the chlorite boundary layer comes into contact with the reagent boundary layer to thereby produce an aqueous chlorine dioxide solution.

Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid and an optional oxidizable colorant, and wherein the first part, the second part, or both the first and second parts comprise an alpha olefin sulfonate.

Abstract: The present invention provides a method of treating a grain or seed to reduce the contamination level of a seed-associated pathogen.

Abstract: The invention relates generally to a method which utilizes iodine as a broad spectrum microbicide wherein the active agent may be applied in nasal passages in the manner of a decongestant type nose spray. The spray is intended particularly for human use. It is to be applied in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents including for example, bacteria, viruses, rickettsia, and even mold and fungus. The active agent is based on an iodine solution and may also contain one or more of the following: sodium hypochlorite solution, or a solution of chlorine or hypochlorites plus a salt of chloride, bromide or iodide. Alternatively, the solution may further contain iodine and a bromine solution, or a solution of iodine, bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide.

Abstract: Polymer mini-emulsions are provided comprising a dispersed phase which comprises particles of a biocompatible hydrophilic polymer and having an average particle size between 50 and 750 nm, the polymer particles comprising a polymer of at least one ethylenically unsaturated monomer; an aqueous continuous phase in which said dispersed phase is dispersed; at least one co-stabilizer effective to stabilize the mini-emulsion; and optionally, a effective amount of at least one pharmaceutical agent, e.g., an anti-microbial agent. Biocompatible hydrophilic films formed from the mini-emulsions are provided, as are methods for making and using these barrier films on mammalian skin, particularly in the therapeutic treatment of serious skin wounds and burns. The flexible films tenaciously adhere to skin and are durable and washable. They preferably are permeable to air and water vapor, but can be formulated to substantially prevent gas or vapor permeation for use in contaminated environments.

Abstract: The invention provides for a nasal spray which is an aqueous solution containing a broad spectrum microbicide which may be applied in nasal passages in the manner of a decongestant type nose spray in the event of known or suspected exposure of the individual to common cold virus, flu, or other infective microbial agents. The solution contains active agents which arebased on a chlorine or hypochlorite solution, or a solution of chlorine or hypochlorite plus a salt of chloride, bromide or iodide. Alternatively, the solution may contain a bromine solution, or a solution of bromine plus a salt of chloride, bromide or iodide such as sodium chloride, zinc chloride, sodium bromide, zinc bromide, sodium iodide or zinc iodide. The chlorine, hypochlorite, bromine, chloride, bromide, and iodide may originally come from inorganic compounds or organic compounds, which are then dissolved in the water. Further, the solution may contain glycerin or another moisturizing or wetting agent for the nasal mucosa.

Abstract: In producing aqueous microbiocidal solutions by oxidation of a water-soluble alkali metal bromide, an intolerable loss of active halogen species has been found to occur during a 10-day period immediately after the product solution has been formed. Surprisingly, this loss has been found to result from an alcohol impurity in the alkali metal bromide used in the process. By eliminating or at least sharply reducing the amount of alcohol impurity in the reaction mixture, products are formed which do not undergo the intolerable loss of active halogen content during the 10-day period.

Abstract: A dry disinfectant composition for the production of aqueous solutions of chlorine dioxide of predetermined concentration is formulated of a mixture of lithium hypochlorite, sodium bisulfate and sodium chlorite. Special liquid and dry formulations are also contemplated for convenience of use, for quality assurance and for safety.

Abstract: The present invention is directed to disinfecting compositions for dental unit water lines, particularly effective against microbial flora in biofilms which form on the luminal walls of the piping and reservoir components of dental equipment, as well as methods related to the use of such compositions to reduce microbial numbers in water-bearing dental and other equipment and maintain reduced levels on a continuous basis.

Abstract: The present invention provides a method for carrying out a germicidal process on microbes, which uses hypochlorous acid or the like. More specifically, the present invention provides a sterilizing method in which an aqueous solution comprising (A) hypochlorous acid and/or a salt thereof, (B) a surfactant and (C) a pH adjusting agent is made in contact with microbes.