Abstract: Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
Type:
Application
Filed:
June 2, 2011
Publication date:
December 8, 2011
Inventors:
Herbert de Groot, Ursula Rauen, Gernot Koehler, Wilfried Bruns
Abstract: The field of colonic diagnostic and surgical procedures is hampered by the lack of optimal means available to cleanse the colon. A compromise between convenient, distasteful, solid or low volume, hyperosmotic solutions which cause considerable fluid and electrolyte imbalances in patients and large volume, difficult to consume, iso-osmotic solutions has had to be made heretofore. This invention describes a low volume, hyper-osmotic solution consisting of sulfate salts with and with out polyethylene glycol, and further comprising a sweetener and/or flavoring. Unlike prior art, this composition is useful for the cleansing of the bowel and, in lower volumes, as a laxative, without producing clinically significant changes in bodily function.
Abstract: A method of preventing or treating conditions of peri-menopausal, menopausal, or post-menopausal skin comprising applying to the skin tissue, a safe and effective amount of a composition comprising between 1.0% to 3% by weight of S-palmitoyl glutathione and a dermatologically acceptable carrier.
Abstract: A composition for the treatment of bruising is disclosed. The composition can include an antioxidant, one or more citrus flavanoids, as active agents along with a pharmaceutically acceptable excipient or filler. The compositions are nutriceutical formulations having the capacity to reduce the number of bruises that occur over time and that reduce the healing time of bruises. The compositions are preferably in tablet form for oral consumption one or more times per day. A method of reducing bruising is also disclosed in which a patient in need of a treatment for bruising or at risk of developing bruises is identified. The composition can then be administered orally to the patient.
Abstract: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.
Abstract: The present invention provides compositions and methods for improving stool quality of a puppy by adjusting the balance of metabolizable cations to metabolizable anions consumed by the puppy.
Abstract: A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.
Type:
Application
Filed:
April 21, 2011
Publication date:
November 17, 2011
Applicant:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors:
Josef Miller, Colleen LePrell, Jochen Schacht, Diane Prieskorn
Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a metal salt (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. In particular the combinations according to the invention are useful to obtain plants with greener leaf color.
Type:
Application
Filed:
April 14, 2011
Publication date:
November 17, 2011
Applicant:
Bayer CropScience AG
Inventors:
Thomas Seitz, Ulrike Wachendorff-Neumann
Abstract: The present invention provides compositions and methods for improving stool quality of a puppy by adjusting the balance of metabolizable cations to metabolizable anions consumed by the puppy.
Abstract: Described herein are compositions that comprise cranberry extract and are potent and low in calories. Methods of preventing or treating infections by administering the described compositions are also provided.
Type:
Application
Filed:
May 12, 2011
Publication date:
November 17, 2011
Inventors:
Alexander S. Herzlinger, Tina Shih-Ping Wu
Abstract: Nutritional approaches for the control of inflammation can involve the administration of therapeutic amounts of calcium. The administration of appropriate amounts of calcium to an individual results in a reduction in inflammatory processes and markers associated with the inflammatory processes. The therapeutic amount of calcium can be selected to change a level of inflammation in the individual. The approach for reducing inflammation can comprise a step of measuring the C-reactive protein marker level and administering calcium in amounts selected to induce a change in the C-reactive protein level. The calcium can be incorporated into a product with corresponding instructions to induce a desired inflammation reduction.
Type:
Application
Filed:
July 22, 2011
Publication date:
November 17, 2011
Inventors:
Eric T. Gugger, Carolyn Good, Ellen M. Silva
Abstract: Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
Type:
Application
Filed:
July 13, 2011
Publication date:
November 3, 2011
Applicant:
WARSAW ORTHOPEDIC, INC.
Inventors:
David Knaack, John Winterbottom, David Kaes, Todd Boyce, Lawrence A. Shimp
Abstract: Methods for facilitating joint immobilization or fusion using selective estrogen receptor modulator (SERM) such as raloxifene are disclosed. The SERM may be administered systemically or locally. In conjunction with SERM, other therapeutic agents such as calcium, vitamin D, bone morphogenetic protein may be administered simultaneously. The method can similarly be applied to facilitate bone repair, bone healing, and connective tissue healing processes in a patient.
Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
Type:
Application
Filed:
July 24, 2009
Publication date:
October 27, 2011
Applicant:
NOVENTIS, INC.
Inventors:
Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
Abstract: Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one predetermined phase of the subject's menstrual cycle to alter the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, including various disease conditions, that increase in severity and/or occurrence during one or more phases of the menstrual cycle. Also provided are systems and kits for use in practicing the subject methods.
Type:
Application
Filed:
June 27, 2011
Publication date:
October 20, 2011
Inventors:
Yun Anthony Joonkyoo, Patrick Yuarn-Bor Lee
Abstract: The present invention relates to a pearl pigment obtained by coating the surface of a flaky powder with a colored metal or a colored metal oxide and further coating the surface of the above colored metal- or colored metal oxide-coated flaky powder with a colorless metal or a colorless metal oxide, wherein when the pearl pigment is applied onto the surface of black artificial leather in an average amount of 0.05 mg/cm2 and the intensity of light reflected from the pearl pigment is measured using illuminant C at a 2° viewing angle with a spectrophotometric colorimeter which is provided with a sheet polarizer S on the light incident side and a sheet polarizer P on the light receiving side, the powder reflection light which is incident to the pearl pigment as a measurement sample at an angle of 45° to the direction normal to the surface of the sample and is received in the direction normal to the surface of the sample has absolute values a* and b* of 10 or less, and make-up cosmetics containing the pearl pigment.
Abstract: Three types of trisiloxane surfactants having the basic formula: MDM? are described wherein the substituents on the differing M and M? groups, in conjunction with pendant polyalkylene oxide substituents on the D group render the surfactant resistant to hydrolysis under either basic or acidic conditions outside the pH range of 6.0 to 7.5. The compositions are useful in agricultural, household and cosmetic applications.
Type:
Application
Filed:
June 22, 2011
Publication date:
October 13, 2011
Applicant:
Momentive Performance Materials Inc.
Inventors:
George A. Policello, Mark D. Leathermani, Wenqing Peng, Suresh K. Rajaraman, Sophia Xia
Abstract: Provided are methods and compositions for treating and preventing hyperproliferative disorders such as psoriasis by administration of a cardiac glycoside alone or in combination locally or systemically with a calciotropic agents and/or a diffusion-limiting component, such a vasoconstrictor or collagen barrier.
Abstract: Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that alter soluble endoglin levels or biological activity.
Abstract: The invention provides a solid, self-bioadhesive composition for topical application that adheres to the oral mucosal tissue comprising a therapeutically effective amount of at least one herbal or homeopathic active agent; and a pharmaceutically acceptable solid bioadhesive carrier in an amount from about 40 to 99 percent based on the weight of the whole composition.
Abstract: The invention provides compositions and methods of treating various conditions, including neurological conditions, with pharmaceutical compositions including a sulfamate (e.g., topiramate) and magnesium.
Abstract: The invention provides compositions and methods for treating pulmonary diseases and conditions. The provided compositions and methods utilize either low concentrations of selective ?-2 adrenergic receptor agonists having a binding affinity of 300 fold or greater for ?-2 over ?-1 adrenergic receptors or ketamine at specific pH. The compositions preferably comprise brimonidine and/or dexmedetomidine and/or ketamine.
Abstract: The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.
Type:
Application
Filed:
September 24, 2009
Publication date:
September 29, 2011
Inventors:
Luke Anthony O'Neill, John O'Leary, Sean Daly, Andrea Scharfe Nugent
Abstract: Provided herein is a method for treating diabetes, said method comprising administering to a subject with diabetes a composition comprising calcium.
Abstract: Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and/or phosphatides and one or more di- or tri-carboxylic acids.
Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of an aptamer and to methods for treating or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions.
Abstract: The invention relates to a drug or a dermatological composition containing an avocado peptide extract for treating and/or preventing pruritus, in particular gravidic pruritus, pruritus sine materia, pruritus in newborns, and pruritus originating from a drug.
Type:
Application
Filed:
November 6, 2009
Publication date:
September 8, 2011
Inventors:
Philippe Msika, Caroline Baudoin, Stéphanie Bredif
Abstract: Multivitamin/Multimineral supplements are provided for supplementing iron and desirable nutrients in the diet of mammals. The supplements include an iron-amino acid chelate, a form of iron more bioavailable than traditional iron salts. The supplements may further include a pharmaceutically accepted salt form of iron as well as other nutritional vitamins and minerals. The supplements are useful for providing iron for pregnant and lactating females as well as for persons suffering from anemia.
Type:
Grant
Filed:
February 27, 2003
Date of Patent:
August 9, 2011
Assignee:
Xanodyne Pharmaceuticals, Inc.
Inventors:
Prasad Nidamarty, William R. Hurd, Roland J. Bydlon, William C. Williams, Michael Dempsey, Amy Erbskorn
Abstract: The present invention provides compositions, systems, kits, and methods for preparation prior to a colonoscopy or other gastrointestinal procedure. In particular, the present invention provides a colon lavage system comprising an aqueous portion and a solid portion.
Abstract: Disclosed herein is a composition containing a high concentration of PG is unexpectedly capable of quickly killing other bacteria, fungi, and/or virus in vitro that is indicative of its potential high efficacy in treating various skin infection. Embodiments disclosed herein relate to a composition and method for effective topical treatment of inflammatory skin lesions in mammals, comprising of a high concentration of propylene glycol alone, or in combination with an astringent. The PG at high concentrations can be regarded as an extremely effective, safe, topical, universal, microbicide.
Abstract: A pure lactoferrin polypeptide containing no more than two metal ions per molecule, or a mixture of the polypeptide and a fragment thereof. The polypeptide or the mixture stimulates skeletal growth and inhibits bone resorption. Also disclosed is a method of treating a bone-related disorder with the polypeptide or the mixture.
Type:
Application
Filed:
April 7, 2011
Publication date:
July 28, 2011
Inventors:
JILLIAN CORNISH, IAN REGINALD REID, KATE PATRICIA PALMANO, NEILL WARD HAGGARTY
Abstract: The present invention provides compositions and methods for treatment of abnormal conditions in a subject, wherein the abnormal condition affects the musculoskeletal joints of the subject.
Type:
Application
Filed:
July 20, 2009
Publication date:
July 28, 2011
Applicant:
Hills Pet Nutrition, Inc.
Inventors:
Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Samer Al-Murrani
Abstract: The present invention relates to a cardioplegic preparation. According to a preferred embodiment of the invention, the preparation is made of two solutions, the first containing magnesium sulfate, potassium and xylitol, and the other containing procaine.
Type:
Application
Filed:
August 10, 2009
Publication date:
July 28, 2011
Inventors:
Erich Gygax, Thierry Carrel, Hendrik Tevaearai
Abstract: A wound or surgical dressing is disclosed. The wound or surgical dressing is configured to cover or surround a wound, a surgical incision, or any type of skin irritation. In accordance with the present disclosure, the wound or surgical dressing is treated with a bacteriostatic composition that is capable of binding and trapping negatively charged matter, such as bacteria, pathogens, and the like. The bacteriostatic composition comprises a cationic polymer, a cationic oligomer, or particles coated with a cationic material. The bacteriostatic composition is bonded to the wound or surgical dressing in a manner such that the bacteriostatic composition is not substantially transferred to a patient being treated.
Type:
Grant
Filed:
December 15, 2005
Date of Patent:
July 26, 2011
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Julie M. Villanueva, Curtis Neil Sayre, Lei Huang, Kevin Peter McGrath, Ning Wei
Abstract: The invention relates to a non-thermal plasma for treatment of a surface, particularly for the treatment of a wound (1), wherein the plasma comprises a partially ionized carrier gas and at least one additive, which preferably has a sterilizing effect on the treated surface and/or improves the healing of the wound (1). Further, the invention relates to a corresponding apparatus and method.
Type:
Application
Filed:
August 17, 2009
Publication date:
July 14, 2011
Applicant:
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V
Inventors:
Gregor Morfill, Bernd Steffes, Tetsuji Shimizu, Rene Pompl, Tetiana Nosenko, Wilhelm Stolz, Georg Isbary, Hans-Ulrich Schmidt
Abstract: Nutritional compositions, formulations, and intermediates are provided which may be utilized to formulate various sweeteners and other products. The formulations described herein are made from constituents found in soils or fossilized soils.
Abstract: A product and method for administering daily micronutrient requirements (DMRs) comprising vitamins, minerals and essential fatty acids targeted to reduce appetite and/or the risks associated with aging and associated cognitive impairment. The DMRs are administered to individuals via food products. In an embodiment of the present invention, the DMRs are offered in the form of a health bar, smoothie, or drink. The DMRs may be incorporated into other forms without departing from the scope of the present invention. By way of illustration and not as a limitation, the constituents may be incorporated into a fruit or yogurt “smoothie,” a frozen desert such as an ice cream or sorbet, and a beverage.
Abstract: Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.
Type:
Grant
Filed:
April 24, 2007
Date of Patent:
July 12, 2011
Assignee:
Medtronic Xomed, Inc.
Inventors:
Matthew F. Myntti, Dana A. Oliver, Cecil O. Lewis
Abstract: The present invention relates to methods and compositions for reducing Distress Dysfunction by restoring and maintaining homeostatic balance in the neurotransmitter systems underlying the Stress Response and the experience of distress and hedonic tone. Distress Dysfunction refers to the experience of dysfunctional emotional and physical distress that interferes with the individual's quality of life and functioning.
Type:
Application
Filed:
December 20, 2010
Publication date:
June 30, 2011
Inventors:
Steven Crain, William E. Crain, Stanley M. Crain, Michael Crain
Abstract: The present invention generally relates to bioactive antibacterial materials and composites that enhance bone growth while preventing surgical site infection. The present invention also relates to bioactive antibacterial materials and composites that include a bimodal bioactive glass particle size distribution. The bioactive antibacterial composite finds utility in a variety of clinical applications including spine and orthopaedic procedures.
Type:
Application
Filed:
December 21, 2009
Publication date:
June 23, 2011
Inventors:
Theodore D. Clineff, Marissa M. Darmoc, Lauren Brown
Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.
Abstract: This disclosure relates to methods of predicting and diagnosing preeclampsia and eclampsia in pregnant subjects. These methods include detecting a decrease of soluble c-kit in a sample obtained from the pregnant subject. A significantly reduced concentration of soluble c-kit in the sample as compared to a gestational age-adjusted control indicates that the pregnant subject will develop or has preeclampsia or eclampsia.
Type:
Application
Filed:
November 29, 2010
Publication date:
June 2, 2011
Inventors:
Carl A. Hubel, Janet M. Catov, Robin E. Gandley, James M. Roberts, Augustine Rajakumar
Abstract: The invention relates to a substance mixture on the basis of a mixture of essential oils, wherein the oil mixture contains juniper oil and turpentine oil, in particular turpentine oil of the duster pine type or substantially comprises them, and wherein the substance mixture preferably furthermore contains a liquid and/or dissolved active ingredient or a mixture of a plurality thereof and/or an active ingredient in powder form or a mixture of a plurality thereof.
Abstract: Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable ?-TCP and a resorbable polymer, wherein the ?-TCP has a total porosity of about 50% or greater and wherein the ?-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject.
Type:
Application
Filed:
November 18, 2010
Publication date:
May 19, 2011
Applicant:
AFFINERGY, INC.
Inventors:
Mora Carolynne Melican, Paul Theodore Hamilton, Jonathan Allen Hodges, Shrikumar Ambujakshan Nair, Yuchen Chen
Abstract: Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.
Type:
Application
Filed:
November 18, 2010
Publication date:
May 19, 2011
Applicant:
AFFINERGY, INC.
Inventors:
Mora Carolynne Melican, Isaac Gilliam Sanford, Jonathan Allen Hodges, Shrikumar Ambujakshan Nair, Martyn Kerry Darby
Abstract: The invention provides compositions and devices for altering biological field effects and methods for their use in therapeutic and agricultural applications. In particular, the invention provides compositions including one or more elemental metals coated with one or more non-conducting or semi-conducting materials and methods for their application to animals (including humans) and/or plants.
Abstract: The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible bronchospasm, severe acute bronchospasm, or acute exacerbation of asthma. The method includes administering to an individual suffering from an acute respiratory attack an effective amount of bedoradrine or a pharmaceutically acceptable salt thereof in combination with a standard of care (SOC) treatment regimen.
Type:
Application
Filed:
November 17, 2010
Publication date:
May 19, 2011
Inventors:
Kazuko MATSUDA, Yuichi Iwaki, Kirk W. Johnson
Abstract: A composition and method for treating a bone condition of an animal. The composition includes a nanoformulation of active ingredients. The active ingredients include Lepidium Sativum or other Lepidium extracts, calcium, vitamin D, and antioxidants. The method for treating a bone condition includes introducing the composition into the animal.
Type:
Application
Filed:
October 27, 2010
Publication date:
May 5, 2011
Inventors:
Shaker A. Mousa, Mohammed H. Qari, Mohammed S. Ardawi
Abstract: Black beans B are coated with a mineral layer 1 containing calcium powder and dolomite powder, a dough layer 2 formed by roasting a dough mixture containing flour, and an outside layer 3 formed by solidifying a seasoning mixture containing, for example, soymilk powder and powdered tea with hardened fat or oil. In 30 parts by weight of black beans, from 2 to 5, both inclusive, parts by weight of the calcium powder, from 30 to 45, both inclusive, parts by weight of the dolomite powder, and from 5 to 15, both inclusive, parts by weight of the soymilk powder, are contained.