Glutamic Acid; Glutamine Patents (Class 435/110)
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Patent number: 8354254Abstract: An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability in a medium containing a processed product of a microalga which promotes production and accumulation of the L-amino acid by the bacterium. The process product is produced by disrupting the culture of the microalga, and/or extracting the culture of the microalga, or fractionating the culture of the microalga or the disrupted culture. The processed product contains a mixture of organic substances produced by the microalga, a hydrolysate of the disrupted microalga culture, and/or an extract or fractionation product of the microalga culture. The processed product can also contain a saccarification product of starch or a hydrolysate of fats and oils. The bacterium is cultured to produce and accumulate the L-amino acid in culture, and the L-amino acid is collected from the culture.Type: GrantFiled: July 23, 2010Date of Patent: January 15, 2013Assignee: Ajinomoto Co., Inc.Inventors: Shigeo Suzuki, Yoshihiro Usuda, Shuhei Hashiro
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Publication number: 20120329095Abstract: Provided is a method of producing succinic acid in which a microorganism having a succinic acid-producing ability is allowed to react with a sugar, the method being characterized in that the ratio of the oxygen transfer rate to the succinic acid production rate (mmol-O2/mol-SA) is 0.1 to 240 and that the doubling time of the microorganism during the reaction is not shorter than 40 hours.Type: ApplicationFiled: September 7, 2012Publication date: December 27, 2012Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Katsunori YOSHIKAWA, Daisuke KIDO, Makoto MURASE
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Publication number: 20120329106Abstract: Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus Escherichia. According to the present invention, a process for producing an L-amino acid comprising; culturing a microorganism in which an activity of the protein of any of the following [1]-[3] is increased compared with that of the parent strain in a medium, producing and accumulating the L-amino acid in the medium, and recovering the L-amino acid from the medium: [1] a protein comprising the amino acid sequence shown in SEQ ID NO: 2 [2] a protein consisting of an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity [3] a protein consisting of an amino acid sequence having 80% or more homology to the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity.Type: ApplicationFiled: January 7, 2011Publication date: December 27, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Mikiro Hayashi, Kazuhiko Tabata
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Publication number: 20120322115Abstract: Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.Type: ApplicationFiled: January 7, 2011Publication date: December 20, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Mikiro Hayashi, Kazuhiko Tabata, Yoshiyuki Yonetani
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Patent number: 8318465Abstract: A process for integrated utilization of the energy and material contents of hydrolysates and solids obtained in the enzymatic hydrolysis of renewable raw materials, in which the resulting hydrolysis solution is used as a carbon source in fermentations and the unhydrolysed solids are sent to biogas production.Type: GrantFiled: April 11, 2008Date of Patent: November 27, 2012Assignee: Evonik Degussa GmbHInventors: Murillo Villela Filho, Isabelle Schaarschmidt, Bernd Wahl, Elmar Rother, Hartmut Zimmermann, Andreas Karau
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Patent number: 8313933Abstract: An L-amino acid can be produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the expression of a yggG gene is enhanced.Type: GrantFiled: August 25, 2009Date of Patent: November 20, 2012Assignee: Ajinomoto Co., Inc.Inventors: Masahito Taya, Motomu Nishioka, Yoshihiro Ojima, Mizuho Komaki, Shintaro Iwatani
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Publication number: 20120276594Abstract: The present invention relates to cellobiohydrolase variants having improved thermostability and/or thermoactivity in comparison to wild-type Myceliophthora thermophila CBH2b.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Applicant: Codexis, Inc.Inventors: Rama Voladri, Xiyun Zhang, Sachin Patil, David Elgart, Gregory Miller, Louis Clark, Kui Chan
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Publication number: 20120276585Abstract: The present invention relates to a method for producing a hydrolysate of from lignocellulose-containing material, comprising pre-treatment with low temperature, hydrolysis and fermentation, wherein hydrolysis is performed by contacting the lignocellulose-containing material with an enzyme composition comprising at least 10% xylanase enzyme protein w/w%.Type: ApplicationFiled: December 21, 2010Publication date: November 1, 2012Applicants: COFCO CORPORATION, NOVOZYMES A/SInventors: Haiyu Ren, Dongmin Li, Yun Wang, Chuanji Fang, Hong Zhi Huang
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Publication number: 20120252075Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.Type: ApplicationFiled: April 3, 2012Publication date: October 4, 2012Applicant: Evonik Degussa GmbHInventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
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Patent number: 8278074Abstract: A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or cells.Type: GrantFiled: March 14, 2011Date of Patent: October 2, 2012Assignee: Ajinomoto Co., Inc.Inventors: Jun Nakamura, Seiko Hirano, Hisao Ito
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Publication number: 20120237979Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: September 30, 2010Publication date: September 20, 2012Applicant: NOVOZYMES A/SInventors: Junxin Duan, Kirk Matthew Schnorr, Wenping Wu
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Publication number: 20120237985Abstract: A method for producing an L-amino acid by culturing a coryneform bacterium having an L-amino acid-producing ability in a medium to produce and accumulate the L-amino acid in the medium or cells of the bacterium, and collecting the L-amino acid from the medium or cells, wherein said coryneform bacterium has been modified to enhance carbonic anhydrase activity.Type: ApplicationFiled: February 24, 2012Publication date: September 20, 2012Inventors: Takeshi Nagahiko, Jun Nakamura
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Publication number: 20120214197Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 30, 2010Publication date: August 23, 2012Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/SInventors: Sara Landvik, Marc Dominique Morant, Keiichi Ayabe, Guillermo Coward-Kelly
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Publication number: 20120214196Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: November 30, 2010Publication date: August 23, 2012Applicants: NOVOZYMES NORTH AMERICA, INC., NOVOZYMES A/SInventors: Sara Landvik, Marc Dominique Morant, Keiichi Ayabe, Guillermo Coward-Kelly
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Patent number: 8222007Abstract: The present invention describes an L-glutamic acid-producing bacterium which belongs to the genus Pantoea, Enterobacter, Klebsiella or Erwinia, wherein the bacterium has been modified by gene recombination to inactivate the rpoS gene. A method is also described for culturing the bacterium in a medium to cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium.Type: GrantFiled: February 18, 2009Date of Patent: July 17, 2012Assignee: Ajinomoto Co., Inc.Inventors: Yoshihiko Hara, Hiroshi Izui
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Patent number: 8211688Abstract: The present invention provides a microorganism belonging to the genus Escherichia in which the activities of glutamine-synthetase adenylyltransferase (GlnE protein) and PII regulatory protein for glutamine synthetase are reduced or lost and which has the ability to form and accumulate L-glutamine or a substance biosynthesized utilizing nitrogen supplied by L-glutamine, and a process for producing L-glutamine or the substance biosynthesized utilizing nitrogen supplied by L-glutamine using the microorganism.Type: GrantFiled: June 24, 2005Date of Patent: July 3, 2012Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata
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Patent number: 8211674Abstract: In a method of making theanine, glutaminase is derived from microbes of one or more of Bacillus, mold and yeast is caused to act on glutamine and ethylamine derivative.Type: GrantFiled: June 22, 2005Date of Patent: July 3, 2012Assignee: Taiyokagaku Co., Ltd.Inventors: Yukitaka Okada, Makoto Ozeki, Nobuyuki Aoi
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Patent number: 8192963Abstract: A bacterium is described which belongs to the Enterobacteriaceae family, and has an ability to produce an L-amino acid, such as L-glutamic acid, L-arginine and L-threonine. The bacterium is modified so that the activity of a protein encoded by ydcI gene is decreased, thereby producing and accumulating the L-amino acid selected from L-glutamic acid, L-arginine, and L-threonine in the culture medium or cells of the bacterium when cultured in a culture medium. Subsequently, the L-amino acid is collected from the culture medium or the bacterium.Type: GrantFiled: March 1, 2011Date of Patent: June 5, 2012Assignee: Ajinomoto Co., Inc.Inventors: Yousuke Nishio, Yoshihiro Usuda
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Patent number: 8187850Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.Type: GrantFiled: January 30, 2008Date of Patent: May 29, 2012Assignee: Ajinomoto Co., Inc.Inventors: Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative
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Patent number: 8187843Abstract: According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.Type: GrantFiled: August 30, 2007Date of Patent: May 29, 2012Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Yugo Adachi, Mikiro Hayashi, Akihiro Senoo, Yoshiyuki Yonetani, Shin-ichi Hashimoto
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Patent number: 8178722Abstract: A method for producing theanine including reacting a glutamic acid alkyl ester represented by general Formula (1): where R1 represents an alkyl group, with a ketone represented by general Formula (2): where R2 represents a hydrogen atom, R3 represents a lower alkanoyl group or a benzoyl group, and R2 and R3 may form a cycloalkanone ring in combination with the vicinal carbon atom, in the presence of t-butylamine, a secondary amine or a tertiary amine, reacting the resultant compound represented by general Formula (3): where R1, R2 and R3 are the same as defined above, with ethylamine, and then being subjected to heating in the presence of the ethylamine or reaction with a fatty acid.Type: GrantFiled: February 1, 2006Date of Patent: May 15, 2012Assignee: Junsei Chemical Co., Ltd.Inventors: Fumio Tonegawa, Kimio Ueda
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Patent number: 8178322Abstract: A method is described for producing an L-amino acid or a nucleic acid by culturing a microorganism having an ability to produce the L-amino acid or nucleic acid in a liquid medium in a fermentation tank containing a stirring impeller, and optionally adding seed crystals to the medium as required to produce and accumulate crystals of the L-amino acid or nucleic acid in the medium, and collecting crystals of the L-amino acid or nucleic acid from the culture. The power density of the stirring impeller is controlled to be 2.4 kW/m3 or lower after either precipitation of the crystals or addition of the seed crystals.Type: GrantFiled: August 14, 2009Date of Patent: May 15, 2012Assignee: Ajinomoto Co., Inc.Inventors: Masayuki Araki, Yusuke Takahashi, Akihiro Watanabe, Fumito Ohnishi, Takahiro Asano, Kazuya Kondo, Wataru Hibino, Shintaro Iwatani, Satoshi Okutani
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Patent number: 8143103Abstract: A method for manufacturing a package stacking system includes: providing a package substrate; mounting an integrated circuit over the package substrate; forming a step-down interposer over the integrated circuit; and molding a stack package body, having a step profile, on the package substrate and the step-down interposer.Type: GrantFiled: January 31, 2011Date of Patent: March 27, 2012Assignee: Stats Chippac Ltd.Inventors: Young-Joon Kim, YoRim Lee
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Patent number: 8129151Abstract: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Pantoea or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.Type: GrantFiled: January 17, 2007Date of Patent: March 6, 2012Assignee: Ajinomoto Co., Inc.Inventors: Mika Moriya, Hiroshi Izui, Eiji Ono, Kazuhiko Matsui, Hisao Ito, Yoshihiko Hara
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Patent number: 8114639Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.Type: GrantFiled: October 17, 2008Date of Patent: February 14, 2012Assignee: Ajinomoto Co., Inc.Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
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Publication number: 20120034659Abstract: Embodiments of the present disclosure relate to a process for producing downstream products, such as fermentable sugars and end products, from a starch substrate by saccharification and/or fermentation. The saccharification is effectively catalyzed by a glucoamylase at a pH in the range of 5.0 to 8.0. At a pH of 6.0 or above, the glucoamylase possesses at least 50% activity relative to its maximum activity. The saccharification and fermentation may be performed as a simultaneous saccharification and fermentation (SSF) process.Type: ApplicationFiled: August 5, 2011Publication date: February 9, 2012Applicant: Danisco US Inc.Inventors: Martien H. Bergsma, Gopal K. Chotani, William A. Cuevas, Gang Duan, Sung Ho Lee, Ying Qian, Vivek Sharma, Jayarama K. Shetty, Bruce A. Strohm, Paula Johanna Maria Teunissen, Hongxian Xu
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Patent number: 8110381Abstract: A method for producing L-glutamic acid by culturing a coryneform bacterium in which the gluX is inactivated in a medium to produce L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium.Type: GrantFiled: February 20, 2008Date of Patent: February 7, 2012Assignee: Ajinomoto Co., Inc.Inventors: Seiko Hirano, Jun Nakamura, Hisao Ito
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Publication number: 20120015409Abstract: The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid.Type: ApplicationFiled: February 9, 2010Publication date: January 19, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko Tabata, Akihiro Senoo
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Publication number: 20110312042Abstract: According to the present invention, a process for producing an amino acid using a microorganism in which aspartate aminotransferase activity is decreased or deleted, and which has the capability of producing and accumulating the amino acid is provided.Type: ApplicationFiled: February 9, 2010Publication date: December 22, 2011Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Hajime Ikeda, Makoto Yagasaki
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Patent number: 8080396Abstract: A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase ?-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.Type: GrantFiled: September 8, 2009Date of Patent: December 20, 2011Assignee: Ajinomoto Co., Inc.Inventors: Seizaburo Shiraga, Noriko Murayama, Hiroshi Izui, Hisao Ito, Hisashi Yasueda, Yoshihiro Usuda, Kazuhiko Matsui
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Patent number: 8076106Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.Type: GrantFiled: August 6, 2009Date of Patent: December 13, 2011Assignee: Richmond Chemical CorporationInventors: Ian Fotheringham, Nicholas Oswald
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Patent number: 8071331Abstract: A method of producing amino acid metal chelates includes producing an amino acid ligand by enzymatically hydrolyzing bacterial cells, and reacting the amino acid ligand with a metal cation.Type: GrantFiled: June 3, 2009Date of Patent: December 6, 2011Assignee: Ajinomoto U.S.A., Inc.Inventors: Paul Summer, Shinya Tachibana, Randall Vos
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Patent number: 8067211Abstract: A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacterium producing the polypeptide has L-glutamine productivity, a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism comprising the DNA or the recombinant DNA, and a process for producing L-glutamine using the microorganism are provided.Type: GrantFiled: December 27, 2006Date of Patent: November 29, 2011Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Mikiro Hayashi, Masaki Maeda, Yoshiyuki Yonetani
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Patent number: 8058035Abstract: A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and ?-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected from the medium or cells to produce the L-amino acid.Type: GrantFiled: June 4, 2009Date of Patent: November 15, 2011Assignee: Ajinomoto Co., Inc.Inventors: Yoshihiko Hara, Hiroshi Izui, Jun Nakamura, Ranko Nishi
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Publication number: 20110244525Abstract: The present invention relates to a transformed microorganism capable of (a) a higher xylose isomerase activity than the equivalent microorganism prior to transformation; and/or (b) a higher growth rate in or on a growth medium comprising xylose than the equivalent microorganism prior to transformation; and/or (c) a faster metabolism of xylose than the equivalent microorganism prior to transformation; and/or (d) a higher production of ethanol when grown anaerobically on xylose as the carbon source than the equivalent microorganism prior to transformation.Type: ApplicationFiled: December 10, 2009Publication date: October 6, 2011Applicant: TERRANOL A/SInventors: Birgitte Rönnow, Thomas Hvid Andersen, Ole Sibbesen
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Publication number: 20110212496Abstract: An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and inherently has a native activity of a glucose dehydrogenase that uses pyrroloquinoline quinone as a coenzyme, but has been modified so that the activity of the glucose dehydrogenase is reduced, in a medium, and collecting the L-amino acid from the medium.Type: ApplicationFiled: March 1, 2011Publication date: September 1, 2011Inventors: Rie Takikawa, Yoshihiko Hara, Gen Nonaka, Kazuhiro Takumi
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Patent number: 8003368Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.Type: GrantFiled: January 7, 2009Date of Patent: August 23, 2011Assignee: Ajinomoto Co., Inc.Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
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Publication number: 20110201062Abstract: A bacterium is described which belongs to the Enterobacteriaceae family, and has an ability to produce an L-amino acid, such as L-glutamic acid, L-arginine and L-threonine. The bacterium is modified so that the activity of a protein encoded by ydcl gene is decreased, thereby producing and accumulating the L-amino acid selected from L-glutamic acid, L-arginine, and L-threonine in the culture medium or cells of the bacterium when cultured in a culture medium. Subsequently, the L-amino acid is collected from the culture medium or the bacterium.Type: ApplicationFiled: March 1, 2011Publication date: August 18, 2011Inventors: Yousuke Nishio, Yoshihiro Usuda
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Publication number: 20110201061Abstract: Disclosed are a method of hydrolysis of wet fiber and a method for preparing ethanol. Generally, an agricultural plant material, such as corn hulls, distiller's dried grains, or spent germ, is treated to at least partially hydrolyze the fiber. The process may include a maceration step followed by a shearing operation in the presence of steam to yield a treated product, in which, in many embodiments, saccharides will be released and unbound from fibrous portions of the agricultural product. In some embodiments, the process includes macerating the material to provide a slurry having a solids content of at least 10 percent and jet cooking the slurry. A mixture of saccharides prepared in this fashion may be fermented to yield ethanol and/or biochemicals.Type: ApplicationFiled: February 16, 2011Publication date: August 18, 2011Inventors: Sarjit Johal, Steven L. Ramsden, Zachary J. Halloran, Albert J. Pollmeier
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Publication number: 20110183382Abstract: This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.Type: ApplicationFiled: December 15, 2010Publication date: July 28, 2011Applicant: Qteros, Inc.Inventors: Matthias Schmalisch, Chelsea Ju, Francis H. Verhoff, Gregory S. Coil
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Publication number: 20110177567Abstract: The invention relates to a method for the production of a fermentation product from lignocellulosic biomass, to a reactor to carry out the method and to use of the reactor to produce a fermentation product.Type: ApplicationFiled: August 12, 2008Publication date: July 21, 2011Inventors: Robert Reurd Christophor Bakker, Edserd De Jong, Ronald Hubertus Wilhelmus Maas, Ruud Alexander Weusthuis, Diana Visser, Hendrik Martinus Winkelaar, Mickel Leonardus August Jansen
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Publication number: 20110177566Abstract: A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine.Type: ApplicationFiled: January 11, 2011Publication date: July 21, 2011Inventors: Ekaterina Alekseevna Savrasova, Natalia Viktorovna Stoynova, Gen Nonaka, Shunsuke Yamazaki, Kazuhiro Takumi
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Publication number: 20110151522Abstract: The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.Type: ApplicationFiled: February 28, 2011Publication date: June 23, 2011Applicant: Novozymes A/SInventor: Allan Svendsen
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Patent number: 7955823Abstract: Disclosed herein are mutant strains, KCCM-10784P and KCCM-10785P, which are obtained through gene manipulation of Corynebacterium glutamicum KFCC-11074, and a process of producing L-glutamic acid using the mutant strains. The mutant strains are capable of producing L-Glutamic acid at high yield.Type: GrantFiled: October 11, 2007Date of Patent: June 7, 2011Assignee: CJ CheilJedang CorporationInventors: Chang hyun Jin, Ki-Hoon Oh, Kwang Myung Cho, Young Hoon Park
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Publication number: 20110124059Abstract: According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.Type: ApplicationFiled: August 30, 2007Publication date: May 26, 2011Applicant: Kyowa Hakko Bio Co., Ltd.Inventors: Yugo Adachi, Mikiro Hayashi, Akihiro Senoo, Yoshiyuki Yonetani, Shin-ichi Hashimoto
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Patent number: 7947303Abstract: A supplement to be administered enterally to maintain or restore the intestinal intestinal barrier of the critically or chronically ill and people with malnutrition is described. This contains as solution, in each case based on a daily dose, a) glutamine and/or glutamine precursors in an amount in the range from 15 to 70 g, b) at least two representatives from the group of substances having antioxidant activity, and c) short-chain fatty acids and/or precursors of short-chain fatty acids in an amount of from 0.5 to 10 g.Type: GrantFiled: November 14, 2001Date of Patent: May 24, 2011Assignee: Fresenius Kabi Deutschland GmbHInventors: Barbara Kessler, Angelika Riedel, Ulrich Suchner
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Patent number: 7943364Abstract: L-glutamine is produced by culturing a coryneform bacterium having L-glutamine-producing ability and modified so that intracellular glutaminase activity is reduced, and preferably also modified so that intracellular glutamine synthetase activity is enhanced. The method of production includes culturing the bacterium in a medium, followed by accumulation of L-glutamine in the medium and collecting the L-glutamine from the medium.Type: GrantFiled: November 25, 2003Date of Patent: May 17, 2011Assignee: Ajinomoto Co., Inc.Inventors: Jun Nakamura, Kayo Akiyama
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Patent number: 7927844Abstract: A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or cells.Type: GrantFiled: August 31, 2009Date of Patent: April 19, 2011Assignee: Ajinomoto Co., Inc.Inventors: Jun Nakamura, Seiko Hirano, Hisao Ito
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Publication number: 20110053227Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the yjcG-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.Type: ApplicationFiled: January 22, 2010Publication date: March 3, 2011Inventor: Nicole DUSCH
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Patent number: RE42350Abstract: A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at the pH. Also provided is a method for producing L-glutamic acid by fermentation, which comprises culturing the microorganism in a liquid medium of which pH is adjusted to a pH at which L-glutamic acid is precipitated, to produce and accumulate L-glutamic acid and precipitate L-glutamic acid in the medium.Type: GrantFiled: April 24, 2009Date of Patent: May 10, 2011Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Izui, Mika Moriya, Seiko Hirano, Yoshihiko Hara, Hisao Ito, Kazuhiko Matsui