Methionine; Cysteine; Cystine Patents (Class 435/113)
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Publication number: 20120183993Abstract: The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally pre-treatment b) optionally washing; c) enzymatic hydrolysis; d) fermentation; and e) optionally recovery of a fermentation product; wherein in step c) an enzyme composition is used that has a temperature optimum of 55 degrees C. or more, the hydrolysis time is 40 hours or more and the temperature is 50 degrees C. or more.Type: ApplicationFiled: October 5, 2010Publication date: July 19, 2012Applicant: DSM IP ASSETS B.V.Inventors: Johannes Petrus Smits, Elisabeth Maria Gierveld, Fop Cornelis Van Der Hor
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Patent number: 8222008Abstract: Pharmaceutical compositions and kits useful for the treatment of cancer include certain alkyl esters of cystine and certain alkyl-substituted cystamine derived esters, including, for example, cystine dimethyl ester and a di-alkyl peptidyl cystamine ester, among others. These compounds may be employed in methods of treating cancers or methods of determining sensitivity of certain cancer cells to apoptosis alone, or in combination with other chemotherapeutic, radiological or apoptotic agents.Type: GrantFiled: April 28, 2009Date of Patent: July 17, 2012Assignee: The Administrators of The Tulane Educational FundInventor: Jess G. Thoene
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Publication number: 20120178128Abstract: The invention provides a process for the conversion of cystine to cystein and/or glutathione comprising contacting cystine with a microorganism. The invention also relates to a yeast extract comprising at least 1.8 mg/g cystein and a yeast autolysate comprising at least 1.3 mg/g cystein.Type: ApplicationFiled: September 28, 2010Publication date: July 12, 2012Applicant: DSM IP ASSETS B.V.Inventor: Bertus Noordam
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Publication number: 20120178966Abstract: A method comprising: (a) enzymatically processing an O-acetylhomoserine (OAHS) fermentation liquor to produce L-methionine and an acetate source; (b) separating at least a portion of said L-methionine from at least a fraction of said acetate source to form separated L-methionine and a residual liquor comprising an acetate-source; and (c) recovering at least a portion of said acetate source from said residual liquor as recovered acetate.Type: ApplicationFiled: December 29, 2011Publication date: July 12, 2012Applicant: CJ CHEILJEDANG CORPORATIONInventors: Soon Won HONG, In Seok HWANG, Sang Mok LEE, Youn Jae LEE, Jun Young JUNG, Aharon Eyal
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Publication number: 20120164698Abstract: The invention relates to a method for preparing organic-chemical compounds, characterized in that the following steps are carried out: a) fermentation of a microorganism secreting an L-amino acid, which microorganism contains an overexpressed polynucleotide coding for a polypeptide having polyphosphate-dependent NAD+ kinase activity, in a fermentation medium, to form a fermentation broth, b) accumulation of said compound in said fermentation broth and/or in the cells of said microorganism. The invention relates to a method for preparing organic-chemical compounds by fermentation of a microorganism in which a polypeptide having polyphosphate-dependent NAD+ kinase is overexpressed.Type: ApplicationFiled: June 18, 2010Publication date: June 28, 2012Applicant: EVONIK DEGUSSA GMBHInventors: Volker F. Wendisch, Steffen Lindner, Brigitte Bathe, Wilfried Claes
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Patent number: 8187850Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.Type: GrantFiled: January 30, 2008Date of Patent: May 29, 2012Assignee: Ajinomoto Co., Inc.Inventors: Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative
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Publication number: 20120123158Abstract: The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.Type: ApplicationFiled: February 26, 2010Publication date: May 17, 2012Applicant: CJ CHEILJEDANG CORPORATIONInventors: So Young Kim, Yong Uk Shin, In Kyung Heo, Hyun Ah Kim, Ju Eun Kim, Chang Il Seo, Sung Kwang Son, Sang Mok Lee, Sung Hoo Jhon, Han Jin Lee, Kwang Ho Na, Il Chul Kim
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Patent number: 8178322Abstract: A method is described for producing an L-amino acid or a nucleic acid by culturing a microorganism having an ability to produce the L-amino acid or nucleic acid in a liquid medium in a fermentation tank containing a stirring impeller, and optionally adding seed crystals to the medium as required to produce and accumulate crystals of the L-amino acid or nucleic acid in the medium, and collecting crystals of the L-amino acid or nucleic acid from the culture. The power density of the stirring impeller is controlled to be 2.4 kW/m3 or lower after either precipitation of the crystals or addition of the seed crystals.Type: GrantFiled: August 14, 2009Date of Patent: May 15, 2012Assignee: Ajinomoto Co., Inc.Inventors: Masayuki Araki, Yusuke Takahashi, Akihiro Watanabe, Fumito Ohnishi, Takahiro Asano, Kazuya Kondo, Wataru Hibino, Shintaro Iwatani, Satoshi Okutani
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Publication number: 20120115186Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia, and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.Type: ApplicationFiled: July 6, 2010Publication date: May 10, 2012Applicant: DSM IP ASSETS B.V.Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Bianca Elisabeth Maria Gielesen, Nicolette Jasmijn Broers, Beate Wiedemann, Wilhelmus Theodorus Antonius Maria De Laat
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Patent number: 8163532Abstract: The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.Type: GrantFiled: May 27, 2009Date of Patent: April 24, 2012Assignee: Evonik Degussa GmbHInventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, R. Rogers Yocum, Thomas A. Patterson, Mark Williams
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Patent number: 8148117Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.Type: GrantFiled: October 23, 2006Date of Patent: April 3, 2012Assignee: Evonik Degussa GmbHInventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Patent number: 8143031Abstract: The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.Type: GrantFiled: February 12, 2009Date of Patent: March 27, 2012Assignee: Metabolic ExplorerInventors: Rainer Figge, Guillaume Barbier, Gwénaëlle Bestel-Corre
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Patent number: 8114649Abstract: L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of L-cysteine in the medium, and collecting L-cysteine from the medium.Type: GrantFiled: December 10, 2009Date of Patent: February 14, 2012Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Takagi, Shigeru Nakamori, Masaru Wada, Hirotada Mori
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Patent number: 8114639Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.Type: GrantFiled: October 17, 2008Date of Patent: February 14, 2012Assignee: Ajinomoto Co., Inc.Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
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Publication number: 20120015409Abstract: The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid.Type: ApplicationFiled: February 9, 2010Publication date: January 19, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko Tabata, Akihiro Senoo
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Publication number: 20110318792Abstract: The object of the present invention is to provide a microbial mutant capable of producing S-adenosylmethionine (hereinafter referred to as SAM) in a large amount with no change in growth characteristics and a method of efficiently producing SAM by incubating the microbial mutant. The method of producing S-adenosylmethionine comprises incubating a microorganism having a loss or a reduction in the function of an enzyme relating to synthesis of phosphatidylcholine and recovering S-adenosylmethionine accumulated in the culture.Type: ApplicationFiled: August 14, 2007Publication date: December 29, 2011Applicant: ISHIHARA SANGYO KAISHA, LTD.Inventors: Toshio Ohsuga, Kuni Fushikida
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Patent number: 8076106Abstract: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.Type: GrantFiled: August 6, 2009Date of Patent: December 13, 2011Assignee: Richmond Chemical CorporationInventors: Ian Fotheringham, Nicholas Oswald
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Patent number: 8071331Abstract: A method of producing amino acid metal chelates includes producing an amino acid ligand by enzymatically hydrolyzing bacterial cells, and reacting the amino acid ligand with a metal cation.Type: GrantFiled: June 3, 2009Date of Patent: December 6, 2011Assignee: Ajinomoto U.S.A., Inc.Inventors: Paul Summer, Shinya Tachibana, Randall Vos
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Publication number: 20110269185Abstract: The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified so as to yield a residual having greater value that a residual produced in the process by a microorganism not so modified. In particular, the present invention contemplates using microorganisms in a fermentation process that have been modified to increase production of a nutrient, such as an essential amino acid, thereby reducing the need to supplement the nutrient in the animal's diet. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals.Type: ApplicationFiled: April 27, 2011Publication date: November 3, 2011Inventor: Peter R. David
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Patent number: 8048651Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.Type: GrantFiled: July 31, 2009Date of Patent: November 1, 2011Assignee: BASF SEInventors: Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner, Burkhard Kröger, Patrick Kiefer, Elmar Heinzle, Christoph Wittmann
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Publication number: 20110229937Abstract: Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.Type: ApplicationFiled: January 31, 2011Publication date: September 22, 2011Applicant: Evonik Degussa GMBHInventors: Markus Pompejus, Burkhard Kröger, Hartwig Schröder, Oskar Zelder, Gregor Haberhauer, Stefan Haefner, Corrinna Klopprogge
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Publication number: 20110223284Abstract: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.Type: ApplicationFiled: October 14, 2010Publication date: September 15, 2011Applicant: Ambrozea, Inc.Inventor: Peter R. David
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Patent number: 8017362Abstract: The present invention provides a method for producing L-methionine by culturing a microorganism in a medium to produce and accumulate L-methionine in the medium, and collecting the L-methionine from the medium, where the microorganism is deficient in a repressor of L-methionine biosynthesis system and has L-methionine productivity.Type: GrantFiled: September 8, 2009Date of Patent: September 13, 2011Assignee: Ajinomoto Co., Inc.Inventors: Yoshihiro Usuda, Osamu Kurahashi
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Patent number: 8012722Abstract: L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetylase activity is enhanced.Type: GrantFiled: July 25, 2008Date of Patent: September 6, 2011Assignee: Ajinomoto Co., Inc.Inventors: Akito Chinen, Hisashi Yasueda, Jun Nakamura
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Publication number: 20110212496Abstract: An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and inherently has a native activity of a glucose dehydrogenase that uses pyrroloquinoline quinone as a coenzyme, but has been modified so that the activity of the glucose dehydrogenase is reduced, in a medium, and collecting the L-amino acid from the medium.Type: ApplicationFiled: March 1, 2011Publication date: September 1, 2011Inventors: Rie Takikawa, Yoshihiko Hara, Gen Nonaka, Kazuhiro Takumi
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Patent number: 8008048Abstract: The present invention provides a bacterium belonging to the family Enterobacteriaceae which has L-cysteine-producing ability and has been modified to decrease the activity of the protein encoded by the yhaM gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, their derivatives, or a mixture thereof is collected from the medium.Type: GrantFiled: March 4, 2009Date of Patent: August 30, 2011Assignee: Ajinomoto Co., Inc.Inventors: Gen Nonaka, Kazuhiro Takumi
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Publication number: 20110207184Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.Type: ApplicationFiled: January 3, 2011Publication date: August 25, 2011Applicant: CJ CHEILJEDANG CORPORATIONInventors: Chul Ha Kim, So Young Kim, Young Uk Shin, Hye Won Um, Jin Sook Chang, Young Wook Cho, Han Jin Lee, In Kyung Heo, Chang II Seo, Kwang Ho Na
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Publication number: 20110207183Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.Type: ApplicationFiled: April 28, 2009Publication date: August 25, 2011Applicant: BASF SEInventors: Andrea Herold, Hartwig Schröder, Weol Kyu Jeong, Corinna Klopprogge, Oskar Zelder, Stefan Haefner, Ulrike Richter, Judith Becker, Christoph Wittmann
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Publication number: 20110183383Abstract: Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed.Type: ApplicationFiled: April 11, 2007Publication date: July 28, 2011Applicant: CJ Cheijedang CorporationInventors: Brian Brazeau, Jin-Sook Chang, Kwang Myung Cho, Young Wook Cho, Mervyn Desouza, Holly J. Jessen, So-Young Kim, Wei Niu, Fernando A. Sanchez-Riera, Yong-Uk Shin, Hyewon Um
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Publication number: 20110177566Abstract: A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine.Type: ApplicationFiled: January 11, 2011Publication date: July 21, 2011Inventors: Ekaterina Alekseevna Savrasova, Natalia Viktorovna Stoynova, Gen Nonaka, Shunsuke Yamazaki, Kazuhiro Takumi
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Patent number: 7951565Abstract: The present invention relates to a process for the production of methionine in an organism such as a microorganism, a non-human animal or plant. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.Type: GrantFiled: March 30, 2005Date of Patent: May 31, 2011Assignee: Metanomics GmbHInventors: Marcus Ebneth, Piotr Puzio, Astrid Blau, Tilmann B. Walk, Volker Haake, Klaus Däschner, Gunnar Plesch
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Publication number: 20110117614Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine.Type: ApplicationFiled: April 27, 2009Publication date: May 19, 2011Applicant: EVONIK DEGUSSA GMBHInventors: Oskar Zelder, Hartwig Schöder, Corinna Klopprogge, Andrea Herold, Stefan Haefner
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Publication number: 20110111466Abstract: The present invention relates to a transformed microorganism producing an L-amino acid using sucrose as a main carbon source, and a method for producing an L-amino acid using the same.Type: ApplicationFiled: February 11, 2010Publication date: May 12, 2011Applicant: CJ Cheiljedang CorporationInventors: Jae Yeong Ju, Kwang Ho Lee, Hyun Ae Bae, Hyo Jin Kim, Keun Chul Lee, Young Bin Hwang, Kyu Soo Cho, Hye Min Park, Hyun Ah Kim
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Publication number: 20110053227Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the yjcG-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.Type: ApplicationFiled: January 22, 2010Publication date: March 3, 2011Inventor: Nicole DUSCH
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Patent number: 7892798Abstract: Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins from Corynebacterium glutamicum are described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g.Type: GrantFiled: November 29, 2002Date of Patent: February 22, 2011Assignee: Evonik Degussa GmbHInventors: Markus Pompejus, Burkhard Kröger, Hartwig Schröder, Oskar Zelder, Gregor Haberhauer, Stefan Haefner, Corrinna Klopprogge
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Patent number: 7888077Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kefB gene.Type: GrantFiled: November 5, 2007Date of Patent: February 15, 2011Assignee: Ajinomoto., Inc.Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
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Publication number: 20110033902Abstract: L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2, (b) a protein comprising the amino acid sequence of SEQ ID NO: 2, but wherein one or several amino acid residues are substituted, deleted, inserted or added, increase of which activity in the bacterium improves the ability of the bacterium to produce L-cysteine.Type: ApplicationFiled: August 18, 2010Publication date: February 10, 2011Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu
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Publication number: 20110033896Abstract: The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention.Type: ApplicationFiled: April 9, 2009Publication date: February 10, 2011Applicant: BASF SEInventors: Matthias Boy, Stephan Freyer, Julia Brodersen
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Publication number: 20100330623Abstract: The present invention relates generally to compositions and methods useful for, inter alia, production of commercial biologic products such as amino acids. More specifically, the present invention relates to genetically modified strains of microorganisms and the use thereof for the production of commercial products. The present invention also provides, inter alia, novel isolated DNA, nucleic acid, vectors and reduced genome bacteria.Type: ApplicationFiled: February 19, 2009Publication date: December 30, 2010Applicant: SCARAB GENOMICS LLCInventors: Frederick R. Blattner, Sun Chang Kim, Jun Hyoung Lee
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Patent number: 7850852Abstract: According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so that a free amino acid is adsorbed on a carbonate-type anion exchange resin packed in the pressure tight column. Subsequently, in the elution step, eluent liquid containing a hydrogen carbonate ion and/or a carbonate ion is injected into the pressure tight column in a pressurized state to elute the amino acid adsorbed on the anion exchange resin and simultaneously to regenarate the anion exchange resin into the carbonate-type. In the case of purifying an acidic amino acid, an aqueous ammonium carbonate solution is employed as the eluent liquid. In the case of purifying a neutral amino acid, an aqueous carbonic acid solution, an aqueous hydrogen carbonate solution, an aqueous ammonium hydrogen carbonate solution or an aqueous ammonium carbonate solution is employed as the eluent liquid.Type: GrantFiled: August 24, 2007Date of Patent: December 14, 2010Assignee: Ajinomoto Co., Inc.Inventors: Yasuhiro Kusunose, Kenji Takahashi
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Patent number: 7846887Abstract: Cysteine derivatives of formula (I) wherein R1-R7 are as defined in the description, and their use as malodor counteractant. Furthermore, a process of their production and consumer products comprising them are described.Type: GrantFiled: June 18, 2008Date of Patent: December 7, 2010Assignee: Givaudan SAInventors: Felix Flachsmann, Markus Gautschi, Thomas McGee, Richard P. Sgaramella
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Publication number: 20100279362Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.Type: ApplicationFiled: January 30, 2008Publication date: November 4, 2010Inventors: Konstantin Vyacheslavovich Rybak, Marina Evgenievna Sheremet'eva, Aleksandra Yurievna Skorokhodova, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov
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Publication number: 20100267094Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.Type: ApplicationFiled: June 28, 2010Publication date: October 21, 2010Inventors: Yury Ivanovich Kozlov, Akito Chinen, Hiroshi Izui, Yoshihiko Hara, Hisashi Yasueda, Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Joanna Yosifovna Katashkina
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Publication number: 20100255544Abstract: The invention relates to coryneform bacteria which, instead of the singular copy of an open reading frame (ORF), gene or allele naturally present at the particular desired site (locus), have at least two copies of the open reading frame (ORF), gene or allele in question, preferably in tandem arrangement, and optionally at least a third copy of the open reading frame (ORF), gene or allele in question at a further gene site, and processes for the preparation of chemical compounds by fermentation of these bacteria.Type: ApplicationFiled: September 3, 2009Publication date: October 7, 2010Applicant: Evonik Degussa GmbHInventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach
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Publication number: 20100248311Abstract: Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.Type: ApplicationFiled: September 25, 2008Publication date: September 30, 2010Applicant: METABOLIC EXPLORERInventor: Rainer FIGGE
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Publication number: 20100233765Abstract: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine, and has been modified to decrease activity of the YdjN protein, or the activities of the YdjN and the FliY protein. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture of these can be collected from the medium.Type: ApplicationFiled: March 11, 2010Publication date: September 16, 2010Inventor: Gen Nonaka
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Patent number: 7790424Abstract: Disclosed herein are a method of preparing an L-methionine production strain by overexpressing proteins involved in L-methionine biosynthesis in an L-threonine production strain, a strain prepared by the method, and a method of producing L-methionine using the strain.Type: GrantFiled: June 16, 2005Date of Patent: September 7, 2010Assignee: CJ Cheiljedang CorporationInventors: Young Hoon Park, Kwang Myung Cho, Yong-Uk Shin, Hyewon Um
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Publication number: 20100221792Abstract: An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is decreased in a medium containing glycerol as the carbon source, and collecting the L-amino acid from the culture.Type: ApplicationFiled: March 30, 2010Publication date: September 2, 2010Inventors: YURI NAGAI, YOSHIHIRO USUDA
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Patent number: 7785846Abstract: The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food supplements or feed supplements.Type: GrantFiled: December 17, 2004Date of Patent: August 31, 2010Assignee: Evonik Degussa GmbHInventors: Matthias Boy, Daniela Klein, Hartwig Schröder
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Publication number: 20100216196Abstract: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof can be collected from the medium.Type: ApplicationFiled: February 24, 2010Publication date: August 26, 2010Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu, Natthawut Wiriyathanawudhiwong, Takeshi Nakatani