Mineral Oil-water Type Patents (Class 514/939)
  • Patent number: 5925364
    Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or aligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: July 20, 1999
    Assignee: L'Oreal
    Inventors: Alain Ribier, Jean-Thierry Simonnet, Jacques Michelet
  • Patent number: 5925681
    Abstract: Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic constituents to provide a disinfecting effect, and are non pine-oil containing. Working strength dilutions of the concentrated aqueous liquid disinfectant compositions are effective against gram positive type pathogenic bacteria such as Staphylococcus aureus, as well as gram negative type pathogenic bacteria such as Salmonella choleraesuis.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: July 20, 1999
    Assignee: Reckitt & Colman Inc.
    Inventors: Michael George Crisanti, Dennis Thomas Smialowicz
  • Patent number: 5902591
    Abstract: Stable topical emulsions for cosmetic/pharmaceutical purposes can be made from a two component system of a powdered ascorbic acid phase and a liquid phase, the liquid phase containing an emulsion stabilizingly effective amount of an organoclay material.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: May 11, 1999
    Assignee: La Prairie SA
    Inventor: Morris Herstein
  • Patent number: 5902590
    Abstract: A cosmetic or pharmaceutical composition containing an emulsifier comprising an ester of palmitic acid and technical grade triglycerol with the proviso that the monoester content of the ester is from 30% to 50% by weight.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: May 11, 1999
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Heike Thomas, Achim Ansmann, Rolf Kawa, Armin Wadle, Reinhard Bunte, Udo Hees, Alfred Westfechtel
  • Patent number: 5888482
    Abstract: An emulsifying composition comprising from 10 to 40 weight % of a mixture alkylpolyglycosides and from 90 to 60 weight % of at least one fatty alcohol of formula R'OH, where R' is a saturated or unsaturated alkyl radical having from 12 to 18 carbon atoms, where the mixture of alkylpolyglycosides comprises:R.sub.1 O(G.sub.1)X.sub.1 (I)in which R.sub.1 is a saturated or unsaturated alkyl radical having 12 or 14 carbon atoms, G.sub.1 is the residue of a sugar and X.sub.1 is between 1 and 5;(ii) an alkylpolyglycoside of formula (II)R.sub.2 O(G.sub.2)X.sub.2 (II)in which R.sub.2 is a saturated or unsaturated alkyl radical having 16 carbon atoms, G.sub.2 is the residue of a sugar and X.sub.2 is between 1 and 5; and(iii) an alkylpolyglycoside of formula (III)R.sub.3 O(G.sub.3)X.sub.3 (III)in which R.sub.3 is a saturated or unsaturated alkyl radical having 18 carbon atoms, G.sub.3 is the residue of a sugar and X.sub.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: March 30, 1999
    Assignee: Societe d'Exploitation de Produits Pour l'Industrie Chimique SEPPIC
    Inventors: Chantal Amalric, Nelly Michel
  • Patent number: 5879689
    Abstract: A skin care composition in the form of an oil-in-water dispersion or emulsion is disclosed. The composition contains an emulsifier capable of forming liquid crystals in water which comprises a fatty acid ester blend of sorbitan fatty acid ester and sucrose fatty acid ester. The ratio of primary oil phase to fatty acid ester blend is in the range of about 6:1 to about 1:1.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: March 9, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Robert Francis Date, Elise Courpron, Zahid Nawaz, Richard George A. Rolls
  • Patent number: 5871754
    Abstract: A make-up composition in the form of water-in-oil or oil-in-water emulsion comprising an acidic anti-active dissolved in the aqueous phase and a pigment or mixture of pigments dispersed in the oil phase. The make-up composition exhibits anti-effectiveness and product and color stability.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: February 16, 1999
    Assignee: The Procter & Gamble Company
    Inventors: Gillian Scott Briggs, Teresa Barbara Crook, Karen Fish, George Endel Deckner
  • Patent number: 5814321
    Abstract: A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40.degree. C. and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a non-reducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: September 29, 1998
    Assignees: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, NOF Corporation
    Inventors: Tokuji Miyahara, Kozo Takase, Koichi Saito, Yoko Kishimoto, Satoru Tokuyama
  • Patent number: 5780517
    Abstract: The present invention relates to solid lipophilic compositions suitable for topical application to human skin and to methods for preparing and using such compositions. The solid lipophilic compositions of the invention comprise dibenzyl monosorbitol acetal (DBMSA), lipophilic materials and one or more cosmetic materials.
    Type: Grant
    Filed: January 8, 1997
    Date of Patent: July 14, 1998
    Assignee: Estee Lauder Inc.
    Inventors: Isaac D. Cohen, Andrew J. Bevacqua, Daniela Toma, Konstantinos M. Lahanas
  • Patent number: 5756108
    Abstract: Composition in the form of a stable dispersion. This composition comprises:(a) from 60 to 98% by weight of an aqueous phase, and (b) from 2 to 40% by weight of an oily phase, said oily phase being dispersed in said aqueous phase and stabilized using cubic gel particles, said particles being essentially formed of:(i) 0.1 to 15% by weight, relative to the total weight of the composition, of at least one component selected from the group consisting of 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol or phytanetriol, N-2-alkoxycarbonyl derivatives of N-methylglucamine and unsaturated fatty acid monoglycerides, and(ii) 0.05 to 3% by weight, relative to the total weight of the composition, of a dispersing and stabilizing agent, said agent being selected from the group consisting of surface-active agents which are water-soluble at room temperature, containing a linear or branched, saturated or unsaturated fatty chain having from 8 to 22 carbon atoms.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: May 26, 1998
    Assignee: L'Oreal
    Inventors: Alain Ribier, Bruno Biatry
  • Patent number: 5753210
    Abstract: A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches to a container of the lotion, e.g., a sunscreen. The pH indicator mixes with the lotion as it is applied to the skin.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: May 19, 1998
    Assignee: SeeUV
    Inventors: John McEleney, Wende Reenstra, Curtis A. Vock
  • Patent number: 5750142
    Abstract: The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component of an oil, about 0.1 to 5 weight percent of a second component of an emulsifier, about 0.25 to 25 weight percent of a cryoprotectant of an amino compound, such as one or more amino acids, peptides or protein hydrolysates, and an aqueous component, wherein the amino compound is present in an amount that is equal to or greater than that of the first component. Optionally, a co-emulsifier, a suspension agent, a preservative, an antioxidant and a drug can be added to these emulsions. Thereafter, the emulsion is lyophilized to form dry compositions that have from about 40 to about 90 weight percent of the amino compound; from about 0.1 to about 20 weight percent of the emulsifier; and from about 0.2 to about 40 weight percent of the oily component.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: May 12, 1998
    Assignee: Pharmos Corporation
    Inventors: Doron Friedman, Yanir Aldouby
  • Patent number: 5747009
    Abstract: Stable skin coloring cosmetic emulsion comprising A) from 50 to 92% by weight, based on the total emulsion weight, of an aqueous phase containing from 0.5 to 10% by weight, based on the total emulsion weight, of dihydroxyacetone and B) from 8 to 50% by weight, based on the total emulsion weight, of a fatty phase comprising from 5 to 15% by weight of isoparaffin or poly-.alpha.-olefin, from 3 to 7% by weight of an emulsifying agent consisting of a mixture of saturated or unsaturated sorbitol and glycerol esters of C.sub.18 fatty acids with a straight or branched chain, optionally including hydroxyl, said esters being oxyethylenated and oxypropylenated, the total number of ethylene oxide and propylene oxide being less than or equal to 5, and from 0 to 15% by weight of the additional fatty bodies, all of the percentages being based on the total emulsion weight. The water-in-oil emulsion can be used to obtain a triple water-in-oil-in-water emulsion.
    Type: Grant
    Filed: March 14, 1996
    Date of Patent: May 5, 1998
    Assignee: L'Oreal
    Inventor: Isabelle Hansenne
  • Patent number: 5744137
    Abstract: A composition of a mixture of nonionic surfactants in water-in-oil emulsion vaccines allows the use of animal, vegetable, and synthetic oils as well as mineral oil and pristane. These non-mineral oil vaccines are as efficacious as mineral oil-containing vaccines without the problems associated with the use of mineral oil.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: April 28, 1998
    Assignee: The United States of America as represented by the Secretary of the Agriculture
    Inventor: Henry D. Stone
  • Patent number: 5738839
    Abstract: The present invention relates to gelled emulsion particles obtained when predetermined volumes, especially drops, of an emulsion with an aqueous external phase, containing an appropriate reagent in solution in the said aqueous phase, are added to a gelling solution and left therein for a period of time which depends on the degree of gelling desired for the said particles.It further relates to compositions--especially solutions, gels or emulsions with an aqueous external phase--in which the said particles are present.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 14, 1998
    Assignee: Helene Rubenstein, Inc.
    Inventors: Anne Clement, Pierre Fodor, Gerard Guth, Nathalie Thiollet
  • Patent number: 5736581
    Abstract: Disclosed are novel polyglycerine polyricinoleates as emulsifiers obtained by the esterification of polyricinoleic acid with a natural condensation rate of from 2 to 10 with a polyglycerine mixture comprising 5-35 wt. % glycerine, 15-40 wt. % diglycerines, 10-30 wt. % triglycerines, 8-20 wt. % tetraglycerines, and 3-10 wt. % pentaglycerines, and the remainder being oligoglycerines. The materials have improved emulsifying capacity.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: April 7, 1998
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Achim Ansmann, Rolf Kawa, Helga Gondek, Gabriele Strauss, Rainer Von Kries
  • Patent number: 5693317
    Abstract: Hair rinse compositions, in emulsion or dispersion form, which condition the hair and facilitates setting thereof, includes a hair conditioning and emulsifying cationic compound, a water insoluble acrylic or acrylate polymer and a solvent which is a stabilizing and compatibilizing proportion of the composition comprising a higher aliphatic alcohol and/or alcohol ethoxylate, in an aqueous medium. The cationic compound is a quarternary ammonium salt preferably a higher alkyl trimethyl ammonium chloride and the polymer is preferably an acrylamide acrylate copolymer. Preferably solvents in the compositions are C.sub.9-20 aliphatic alcohols and/or C.sub.9-20 alcohol ethoxylates having less than 2 ethoxy groups per mole.The preferred emulsion, which is normally of the oil-in-water type, preferably includes propylene glycol and a nonionic surfactant, and the aqueous medium is preferably water, or is essentially water. The invention also includes processes for making and using the invented hair rinse compositions.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignee: Colgate-Palmolive Company
    Inventors: Charles Reich, Donna A. Hartnett, Clarence R. Robbins, Kurt T. Sackariasen, Amrit M. Patel
  • Patent number: 5679351
    Abstract: A clove oil formulation which inhibits soil-borne fungal diseases is disclosed. The formulation includes about 70-90% by weight rectified clove oil, and about 2-30% by weight surfactant. The surfactant includes about 15-95% by weight nonionic compounds such as ethoxylated monoglycerides, ethoxylated diglycerides, ethoxylated alcohols, silicone glycol copolymers, sorbitan fatty acid esters, ethoxylated alkyl phenols, ethylene oxide block copolymers, and propylene oxide block copolymers. The surfactant further includes about 5-85% by weight anionic compounds such as amine alkylaryl sulfonate, calcium alkylaryl sulfonate and phosphate esters. The formulation may also include up to about 30% by weight of a solvent such as alcohol, esters, glycol ethers, mineral oil, methyl esters and hydrocarbon solvents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 21, 1997
    Assignee: Thermo Trilogy Corporation
    Inventors: James Frederic Walter, James Charles Locke, Michele Carter Normoyle
  • Patent number: 5674475
    Abstract: Emulsifier composition is a mixture of polyglycerol fatty acid ester (n.gtoreq.4) and the lactylate of a fatty acid (C.gtoreq.8) or its salt and is used to manufacture a wide range of different O/W emulsions, e.g. sunscreen emulsions for cosmetics. The polyglycerol fatty acid ester preferably has an HLB value.ltoreq.8. The emulsifier composition can additionally contain a lipophilic emulsifier.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: October 7, 1997
    Assignees: IFAC GmbH, Nikko Chemicals Co., Ltd.
    Inventors: Gerd H. Dahms, Masato Tagawa
  • Patent number: 5670139
    Abstract: Stable and homogeneous, topically applicable sunscreen/cosmetic compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-A and/or UV-B irradiation, particularly solar radiation, and which display excellent transparency on the skin, comprise a storage-stable, ultrafine oil-in-water emulsion resistant to phase separation/settling, of a photoprotecting effective amount of homogeneously and finely dispersed particulates of at least one inorganic nanopigment which comprises a metal oxide, for example titanium dioxide, as well as a stabilizing amount of at least one mixed silicate which comprises alkali and/or alkaline earth metals, and further wherein the average particle size of the globules comprising the oily phase of the emulsion characteristically ranges from 100 nm to 1,000 nm.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: September 23, 1997
    Assignee: L'Oreal
    Inventors: Delphine Allard, Jean-Marc Ascione
  • Patent number: 5645842
    Abstract: Cosmetic or pharmaceutical preparations, which contain natural or synthetic oils having ester groups or mineral oils, are characterized by containing a selected organopolysiloxanes with long-chain alkyl or alkoxy groups for improving the spreading behavior of the oils, particularly on the human skin. The organopolysiloxanes are added to the oil in amounts of 0.003 to 20% by weight, based on the total weight of oil and organopolysiloxane.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: July 8, 1997
    Assignee: Th. Goldschmidt AG.
    Inventors: Burghard Gruning, Christian Weitemeyer
  • Patent number: 5629314
    Abstract: This invention is directed to a method for reducing pyrimidine photoproducts comprising applying an effective amount of melanin to human skin prior to exposure to ultraviolet rays, wherein said melanin is in a vehicle suitable for topical application and measuring the amount of pyrimidine photoproducts as compared to a control sample. Another embodiment of this invention is where the vehicle is an ointment, cream or lotion. For the purpose of this invention, measuring also means determining, and/or quantifying.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: May 13, 1997
    Inventor: Frances C. Gaskin
  • Patent number: 5618519
    Abstract: A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: April 8, 1997
    Assignee: Yale University
    Inventors: John M. Pawelek, Seth J. Orlow
  • Patent number: 5610187
    Abstract: Disclosed are conditioning compositions for the hair and skin containing compounds of the formula (R.sup.1)(R.sup.2)N(CHCH.sub.2 OC(O)R).sub.2 X.sup.- wherein R.sup.1 is alkyl containing 1 to 6 carbon atoms, or hydroxyalkyl containing 1 to 6 carbon atoms; R.sup.2 is alkyl containing 1 to 6 carbon atoms, or benzyl; X.sup.- is an anion; and R is alkyl and alkylene of 12 to 22 carbon atoms having 0 to 3 carbon--carbon double bonds, provided that at least 2 different chain lengths R are present and 0, 1 and 2 such double bonds are present.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 11, 1997
    Assignee: Witco Corporation
    Inventors: Monna M. Manning, Andrea S. Allardice, Floyd Friedli
  • Patent number: 5610199
    Abstract: The present invention relates to solid lipophilic compositions suitable for topical application to human skin and to methods for preparing and using such compositions. The solid lipophilic compositions of the invention comprise dibenzyl monosorbitol acetal (DBMSA), lipophilic materials and one or more cosmetic materials.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: March 11, 1997
    Assignee: Estee Lauder Inc.
    Inventors: Isaac D. Cohen, Andrew J. Bevacqua, Daniela Toma, Konstantinos M. Lahanas
  • Patent number: 5607979
    Abstract: Creams formed from about 35% to about 50% fine particulates of certain poly(tetrafluoroethylene) (PTFE) resins dispersed in perfluorinated polyether oils having viscosities from about 20 cSt to about 350 cSt afford good protection against chemical warfare agents such as sulfur mustard (HD), lewisite (L), sulfur mustard/Lewisite mixtures (HL), pinacolyl methylphosphonofluoridate (soman or GD), thickened soman (TGD) and O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (vx).
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: March 4, 1997
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Michael J. McCreery
  • Patent number: 5603940
    Abstract: The present invention relates to a stable oil-in-water emulsions comprising an oily phase dispersed in an aqueous phase with an emulsifying system. More precisely, the emulsifying system contains a first ester chosen from the fatty acid esters of glucose and the fatty acid esters of alkylglucose and at least one second fatty acid ester of sucrose. The emulsion according to the invention may be used in the cosmetic field and in the field of dermatology in order to obtain a skin cream.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: February 18, 1997
    Assignee: L'Oreal
    Inventors: Didier Candau, Pascal Simon
  • Patent number: 5602182
    Abstract: There is provided a taste masked liquid pharmaceutical composition for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the composition comprises a taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of a normally solid polyethylene glycol and sodium carboxymethylcellulose.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 11, 1997
    Assignee: American Home Products Corporation
    Inventors: Shankar D. Popli, Zenaida O. Go
  • Patent number: 5580579
    Abstract: Nanoparticulate crystalline therapeutic or diagnostic substances formulated with stabilizers and high molecular weight, linear poly(ethylene oxide) polymers, enhance contact between the crystalline therapeutic or diagnostic substances and the gastrointestinal tract providing site-specific and extended therapeutic or diagnostic effect.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: December 3, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge
  • Patent number: 5578310
    Abstract: A topical bioadhesive ointment composition comprising an aqueous mineral oil emulsion which is readily spread able and film-forming, and, upon application to moist skin or a mucosal surface, forms a stable, coherent layer thereon which resists removal therefrom by water or a body fluid associated with the mucosal surface to which the ointment composition is applied is disclosed. Also disclosed are pharmaceutical compositions containing the ointment compositions and a pharmaceutically active agent, e.g. , TGF.alpha.; and methods of using and methods of preparing the compositions.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: November 26, 1996
    Assignee: Berlex Laboratories Inc.
    Inventors: Thabiso M'Timkulu, Ze'ev Shaked, Richard Hsu
  • Patent number: 5569465
    Abstract: An aqueous cosmetic or dermo-pharmaceutical composition contains, in suspension in the continuous phase, hydrated spheroids of a hydrophilic lipidic substance. The hydrated spheroids have an average particle diameter ranging from 50 to 10,000 .mu.m. A process for the preparation of this composition is described.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: October 29, 1996
    Assignee: L'Oreal
    Inventor: Myriam Kauffmann
  • Patent number: 5567427
    Abstract: Emulsified, low pH cosmetic compositions having improved pH stability and phase stability are disclosed. The emulsified cosmetic compositions have a pH of about 3.7 to about 4.5, and contain about 10% to about 50% by weight of a dispersed oil phase, about 2% to about 20% by weight of an acid, like a hydroxycarboxylic acid, and about 0.5% to about 2% of a quaternized phosphate ester, like linoleamidopropyl PG-dimonium chloride phosphate. The emulsified cosmetic compositions are phase stable over an extended storage period and maintain an essentially constant pH by exhibiting a pH drift of about 0.15, and usually 0.1, pH unit or less.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: October 22, 1996
    Assignee: Helene Curtis, Inc.
    Inventor: Marcelline C. Papadakis
  • Patent number: 5560931
    Abstract: Nanoparticulate crystalline drug substances formulated in an aqueos phase emulsified in oil, are able to be made at less than 1000 nm size and provide increased bioavailability and lymphatic uptake following oral administration.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: October 1, 1996
    Assignee: NawoSystems L.L.C.
    Inventors: W. Mark Eickhoff, Karl R. Mueller, David A. Engers
  • Patent number: 5558872
    Abstract: A clear, gelled mineral oil based skin protectant especially adapted for irritated skin is provided. The product is clear so the underlying compromised skin can be seen, does not have the normal high drag of petrolatum based products and does not dry out. It contains a mineral oil gel blend which is a hydrocarbon mineral oil blended with di- and tri-block copolymers of hydrogenated butylene/ethylene/styrene copolymer and hydrogenated ethylene/propylene/styrene copolymer.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: September 24, 1996
    Assignee: Healthpoint Medical Limited Partnership
    Inventors: David P. Jones, William H. Woller, Cynthia W. Jewett
  • Patent number: 5534554
    Abstract: A stable, efficacious therapeutic cream wherein a principal therapeutic compounds are one or more C-20 to C-28 long chain aliphatic alcohols, of which n-docosanol is exemplary, comprising sucrose cocoate, sucrose stearates or sucrose distearate, or mixtures thereof, is disclosed.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: July 9, 1996
    Assignee: Lidak Pharmaceuticals
    Inventors: David H. Katz, Mohammed H. Khalil, John F. Marcelletti, Laura E. Pope, Lee R. Katz
  • Patent number: 5531993
    Abstract: Oil-in-water type emulsions having a pH below or equal to 3.5, especially a pH below or equal to 3, and comprising as a stabilizing agent a substantially water-soluble crosslinked anionic copolymer consisting of units derived from the reaction between (i) acrylamide, (ii) 2-acrylamido-2-methylpropanesulfonic acid and (iii) at least one compound possessing multiple olefinic unsaturation (crosslinking agent), in which the compound possessing multiple olefinic unsaturation is present in the copolymer at a concentration of between 0.06 and 1 mmol per mole of the collective monomer units, are stable.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: July 2, 1996
    Assignee: L'Oreal
    Inventor: Jacqueline Griat
  • Patent number: 5532000
    Abstract: An aqueous cosmetic or dermo-pharmaceutical composition contains, in suspension in the continuous phase, hydrated spheroids of a hydrophilic lipidic substance. The hydrated spheroids have an average particle diameter ranging from 50 to 10,000 .mu.m. A process for the preparation of this composition is described.
    Type: Grant
    Filed: April 4, 1991
    Date of Patent: July 2, 1996
    Assignee: L'Oreal
    Inventor: Myriam Kauffmann
  • Patent number: 5508022
    Abstract: The present invention relates to gelled emulsion particles obtained when predetermined volumes, especially drops, of an emulsion with an aqueous external phase, containing an appropriate reagent in solution in the said aqueous phase, are added to a gelling solution and left therein for a period of time which depends on the degree of gelling desired for the said particles.It further relates to compositions--especially solutions, gels or emulsions with an aqueous external phase--in which the said particles are present.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 16, 1996
    Assignee: Helena Rubinstein Inc.
    Inventors: Anne Clement, Pierre Fodor, Gerard Guth, Nathalie Thiollet, married name Lilienthal
  • Patent number: 5500217
    Abstract: A personal care formulation which contains, as an anti-microbial agent, a compound containing the structure --C(S)--N(OR)-- or a salt or complex thereof, for example a 2:1 complex or salt of 3-hydroxy-4-methylthiazol-2(3H)thione and zinc. The personal care formulation may be an oil-in-water or water-in-oil emulsion such as hand lotions and emollient creams, or may be shampoos and the like. The anti-microbial agent has good activity against micro-organisms together with a low toxicity.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: March 19, 1996
    Assignee: Zeneca Limited
    Inventors: Peter W. Austin, Michael Singer
  • Patent number: 5500224
    Abstract: A pharmaceutical composition in the form of a colloidal suspension of nanocapsules, comprising an oily phase consisting essentially of an oil containing dissolved therein a surfactant and suspended therein a plurality of nanocapsules having a diameter of less than 500 nanometers, said nanocapsules encapsulating an aqueous phase consisting essentially of a solution or a suspension of a therapeutically active substance, a surfactant and optionally ethanol; a process for preparing the said composition is also described. The walls of said nanocapsules are formed from a poly(alkyl 2-cyanoacrylate) wherein the alkyl radical has 1 to 6 carbon atoms. This composition is particularly suitable for oral administration of polypeptides and polysaccharides.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: March 19, 1996
    Assignee: U C B S.A.
    Inventors: Henri Vranckx, Martine Demoustier, Michel Deleers
  • Patent number: 5478561
    Abstract: The invention relates to a novel process for the preparation of stable complex multiple emulsions of the water-oil-water type which are well suited for use in cosmetic preparations. The primary emulsions of the W/O type are prepared in the presence of both a non-ionic polymeric lipophilic emulsifier and a non-ionic polymeric stabiliser each preferably having an HLB value in the range from 6 to 10. In a second process step more water containing a hydrophilic emulsifier having a higher HLB value, preferably in the range from 12 to 25, is added to the primary emulsion until phase inversion occurs. It is important that the procedure in this second process step is not reversed, i.e. that the primary emulsion is not added to the aqueous phase. Further active substances, such as UV filters and vitamins, may be added to the aqueous or oil phase respectively.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: December 26, 1995
    Assignee: Lancaster Group AG
    Inventor: Louis Ferrero
  • Patent number: 5472706
    Abstract: The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component of an oil, about 0.1 to 5 weight percent of a second component of an emulsifier, about 0.25 to 25 weight percent of a cryoprotectant of an amino compound, such as one or more amino acids, peptides or protein hydrolysates, and an aqueous component, wherein the amino compound is present in an amount that is equal to or greater than that of the first component. Optionally, a co-emulsifier, a suspension agent, a preservative, an antioxidant and a drug can be added to these emulsions. Thereafter, the emulsion is lyophilized to form dry compositions that have from about 40 to about 90 weight percent of the amino compound; from about 0.1 to about 20 weight percent of the emulsifier; and from about 0.2 to about 40 weight percent of the oily component.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: December 5, 1995
    Assignee: Pharmos Corp.
    Inventors: Doron Friedman, Yanir Aldouby
  • Patent number: 5438041
    Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: August 1, 1995
    Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.
    Inventors: Shuming Zheng, Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
  • Patent number: 5407920
    Abstract: A method of treating wood and timber is disclosed. Wood or timber is treated with a pesticidal microemulsion or other water-miscible formulation that has an average particle size of at most 200 nm. The treatment is particularly effective in protecting wood and timber against the common furniture beetle (Anobium punctatum), the house longhorn (Hylotrupes bajulus), the death watch beetle (Xestobium rufovillorum), dry rot (Serpula (merulius) lacrymans) and wet rot (Coniophora puteena).
    Type: Grant
    Filed: August 26, 1993
    Date of Patent: April 18, 1995
    Assignee: NC Development, Inc.
    Inventor: Howard B. Dawson
  • Patent number: 5385605
    Abstract: This invention relates to methods and compositions for obtaining synergistic anti-microbial (biocidal) activity using a combination of methylene(bisthiocyanate) and 2-bromo-2-nitropropane-1,3-diol. The methods and compositions of the invention are very effective in preventing microbial spoilage of latex carpet backing compounds and in paper and pulp preparation, particularly with respect to latex paper coatings. Compositions containing the active ingredients in ratios of from 0.001 parts methylene(bisthiocyanate) to 1 part 2-bromo-2-nitro-propane-1,3-diol to 10 parts methylene(bisthiocyanate) to 1 part 2-bromo-2-nitro-propane-1,3-diol.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: January 31, 1995
    Assignee: Nalco Chemical Company
    Inventor: Allen R. Syrinek
  • Patent number: 5382381
    Abstract: The present invention relates to a process for the preparation of stable oil in water emulsions which comprises (a) mixing an oil with effective emulsifying concentration of a silicone based phosphate ester (b) subsequently adding water and in a final step (c) homogenizing the resulting mixture to obtain an surprisingly stable emulsion.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: January 17, 1995
    Assignee: John Imperante
    Inventors: John Imperante, John H. Hannon
  • Patent number: 5364632
    Abstract: A pharmaceutical composition being an oil in water type emulsion which comprises an effective amount of a lypophilic drug is provided. The composition comprises a synergistic combination consisting of about 3-50% of an oily carrier consisting of MCT oil optionally in combination with vegetable oil, about 0.05%-20% of a phospholipid, about 0.03-10% of a non-ionic surfactant, and about 0.05-5% of an ionic surfactant selected from the group consisting of bile-duct surface active agent, cholic acid and their derivatives.
    Type: Grant
    Filed: March 9, 1993
    Date of Patent: November 15, 1994
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Simon Benita, Menashe Levy
  • Patent number: 5362418
    Abstract: A gel-like emulsion is prepared by adding an oil to a surfactant continuous phase formed of a monoalkyl phosphate salt, polyhydric alcohol and water.The gel-like emulsion is scarcely dependent on temperature, and a fine and uniform O/W emulsion prepared from the gel-like emulsion reveals excellent stability at the time of production and at storage. The gel-like emulsion contains only a small amount of alkyl phosphate surface active agent of low irritativeness, so that it is usable for cosmetics, pharmaceuticals, industrial products and the like, which are required to have low irritation and high safety.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: November 8, 1994
    Assignee: Kao Corporation
    Inventors: Seiji Yamasaki, Toshiyuki Suzuki, Chikako Hirata
  • Patent number: 5330681
    Abstract: Stable diphase emulsions consisting of:a) perfluoropolyethers having perfluoroalkyl end groups;b) a conventional surfactant, dispersed inc) a continuous dispersing phase consisting of glycerol or of a polyhydroxylated compound containing at least three hydroxyl groups, selected from polyalcohols and saccharides, dissolved in a hydrophile solvent and/or water.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: July 19, 1994
    Assignee: Ausimont S.r.l.
    Inventors: Fabio Brunetta, Giovanni Pantini
  • Patent number: 5324507
    Abstract: The invention relates to a composition for washing keratinous materials, in particular the hair and/or the skin, comprising, in an aqueous medium, at least one hydrocarbon oil, at least one surface-active agent possessing detergent properties and at least one alcohol having 17 to 44 carbon atoms and containing one or two ether and/or thioether or sulphoxide groups, of the formula (I):R.sub.1 --X--[C.sub.2 H.sub.3 (OH)]--CH.sub.2 --Y--R.sub.2 (i)in whichR.sub.1 and R.sub.2, which are identical or different, denote linear C.sub.12 to C.sub.20 alkyl groups;X denotes an oxygen atom, a sulphur atom or a sulphoxide group;Y denotes an oxygen atom, a sulphur atom, a sulphoxide group or a methylene group;in the case where Y denotes a methylene group, the sum of then umber of carbon atoms in R.sub.1 to R.sub.2 ranges from 24 to 40, and when Y does not denote a methylene group, the sum of the carbon atoms in R.sub.1 and R.sub.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: June 28, 1994
    Assignee: L'Oreal
    Inventors: Claude Dubief, Daniele Cauwet