Composition Suitable For Use As Tissue Or Body Member Replacement, Restorative, Or Implant Patents (Class 523/113)
-
Patent number: 8641686Abstract: An anti-biofilm catheter comprising a tubing configured to be disposed within a luminal system, wherein the tubing comes in contacting engagement with a blood flow within the luminal system in vivo. The catheter comprises a surface disposed over at least a portion of the tubing, wherein the surface comprises a surface profile having a skewness value of from about ?0.01 to about ?0.6 such that few or no components of the blood flow is capable of attaching themselves to the surface to encourage biofilm formation. The surface profile further comprises a kurtosis value of from about 2.7 to 3.3.Type: GrantFiled: January 20, 2012Date of Patent: February 4, 2014Inventor: Rabie Stephan
-
Patent number: 8642064Abstract: A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture.Type: GrantFiled: November 25, 2004Date of Patent: February 4, 2014Assignee: Curasan AGInventors: Matthias Schnabelrauch, Sebastian Vogt, Ute (Erbe) Reif
-
Publication number: 20140031450Abstract: The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.Type: ApplicationFiled: June 19, 2013Publication date: January 30, 2014Inventors: Csaba Truckai, Andrew Kohm, John Shadduck, Robert Luzzi
-
Publication number: 20140012365Abstract: A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Byron Lambert, Yunbing Wang, James Oberhauser
-
Patent number: 8623986Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.Type: GrantFiled: April 19, 2007Date of Patent: January 7, 2014Assignee: Aertech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay Padsalgikar
-
Publication number: 20140005293Abstract: The present disclosure is directed to polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be advantageously used to make orthopedic implants. The disclosure also provides methods for selecting antioxidants providing desirable properties to the polymer composition. In one embodiment, a measure of OIT can be used to select the antioxidant and antioxidant blend. In another embodiment, measurements of OIT and OI-rate can be used to select the one or more antioxidants. In an other embodiment, the product of OIT and crosslink density can be calculated to predict wear resistance and oxidation resistance of a polymer composition including one or more antioxidants.Type: ApplicationFiled: December 5, 2011Publication date: January 2, 2014Applicant: Zimmer, Inc.Inventors: Brian H. Thomas, Dean M. Acker, Ray Gsell, Norman Stark
-
Publication number: 20140004252Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing said copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettabilty of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.Type: ApplicationFiled: August 11, 2011Publication date: January 2, 2014Applicants: UNIVERSITY OF WESTERN ONTARIO, LANXESS INC.Inventors: Goran Stojcevic, Gilles Arsenault, Elizabeth R. Gillies, Colin V. Bonduelle, Matthew J. McEachran
-
Patent number: 8617519Abstract: An injectable hydrogel composition comprising: water; and poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of: a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof, wherein the cross-linked resin has a degree of cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, and wherein the hydrogel is flowable when heated above its melting point.Type: GrantFiled: July 7, 2011Date of Patent: December 31, 2013Assignee: DePuy Synthes Products, LLCInventors: Valerie R. Binetti, Kristin B. Kita, Garland W. Fussell, Anthony M. Lowman, Michele S. Marcolongo
-
Publication number: 20130345334Abstract: One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer.Type: ApplicationFiled: January 2, 2012Publication date: December 26, 2013Applicant: BENDER ANALYTICAL HOLDING B.V.Inventors: Richard Hoogenboom, Johannes Caspar Mathias Elizabeth Bender, Jan Cornelis Maria van Hest
-
Patent number: 8613877Abstract: Methods relating to polymer-bioceramic composite implantable medical devices are disclosed.Type: GrantFiled: January 25, 2013Date of Patent: December 24, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Bin Huang, David C. Gale
-
Patent number: 8604099Abstract: The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, optionally body derived fluids, and at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-containing diols or polyols in which essentially all of hydroxyl groups are capped with polyisocyanate.Type: GrantFiled: March 16, 2012Date of Patent: December 10, 2013Assignee: Promethean Surgical DevicesInventor: Michael T. Milbocker
-
Publication number: 20130324637Abstract: It is a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.Type: ApplicationFiled: August 9, 2013Publication date: December 5, 2013Applicant: Abbott Cardiovascular Systems Inc.Inventor: Stephen D. Pacetti
-
Publication number: 20130324636Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.Type: ApplicationFiled: August 7, 2013Publication date: December 5, 2013Applicant: Abbott Cardiovascular Systems Inc.Inventors: David C. GALE, Yunbing WANG, Syed Faiyaz Ahmed HOSSAINY, Bin HUANG, Garth WIKES, Vincent J. GUERIGUIAN
-
Patent number: 8597673Abstract: A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.Type: GrantFiled: December 13, 2006Date of Patent: December 3, 2013Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Mikael O. Trollsas, Michael Huy Ngo, Bozena Zofia Maslanka, Syed Faiyaz Ahmed Hossainy, Lothar W. Kleiner
-
Publication number: 20130312764Abstract: A composition for use in occluding a body duct, such as female sterilization or blocking the urethra, in a living creature with a plug prepared in situ from a composition of an addition curable polysiloxane system.Type: ApplicationFiled: May 23, 2013Publication date: November 28, 2013Inventor: Jan Albert de VRIES
-
Publication number: 20130295081Abstract: The presently-disclosed subject matter includes polyurethane composites that include tissue component(s), as well as methods of making such composites and uses thereof. The polyurethane component can comprise a polyisocyanate prepolymer and a polyol. The tissue component can be a polysaccharide. Exemplary composites can be moldable and/or injectable, and can cure into a porous composite that provides mechanical strength and/or supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shaped areas, voids, or the like. Exemplary composites can be used for treating wounds.Type: ApplicationFiled: April 16, 2013Publication date: November 7, 2013Inventors: Scott A. Guelcher, Andrea Hafeman, Jeffrey Davidson, Lillian M. Nanney, Elizabeth Adolph
-
Patent number: 8574611Abstract: The present invention relates to a sliceable composite bone repair material comprising a porous block-shaped ceramic scaffold and a stabilizing polymer disposed therein. Said ceramic scaffold is a synthetic ceramic material or a naturally-derived material. Additionally said scaffold comprises interconnected macropores.Type: GrantFiled: June 30, 2008Date of Patent: November 5, 2013Assignee: Straumann Holding AGInventors: Reinhart Seibl, Aaldert Rens Molenberg, Astrid Sylvia Neidhardt, Nienke Beuling
-
Patent number: 8575229Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.Type: GrantFiled: November 7, 2008Date of Patent: November 5, 2013Assignees: Suntech Co., LtdInventors: Hyung Il Kim, Kazuhiko Ishihara
-
Publication number: 20130287735Abstract: Materials and methods for preparing three dimensional scaffolds are described. The materials, as improved high internal phase emulsions (HIPES), and the polymerization thereof may be suitable for injection prior to curing and when in an injectable form may be for site-directed in vivo use, curing after injection. In addition, said materials before curing may be engineered as a tissue substitution or enhancement and/or to include cell encapsulation. Said materials described herein form a monolith after curing and are biodegradable and porous after curing. Said materials are made from starting molecules using a process that does not rely on toxic solvents or monomers. Making of said materials to form the emulsion take advantage of one or more surfactants for HIPE stability. In addition, said materials cure at temperatures appropriate for use in an in vivo or in situ environment.Type: ApplicationFiled: October 12, 2012Publication date: October 31, 2013Inventor: The Texas A&M University System
-
Patent number: 8569395Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.Type: GrantFiled: July 31, 2012Date of Patent: October 29, 2013Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral
-
Patent number: 8563626Abstract: The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrrole and polyethylenglycol copolymers and iodine-doped and plasma-synthesized pyrrole polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury; this effect was proved in a model involving a complete section of the spinal cord in rats; the results o the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrrole-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord; in addition, the functional recovery of the group with iodine-doped polypyrrole was ten times greater compared to the control group; in the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also obseType: GrantFiled: June 1, 2007Date of Patent: October 22, 2013Assignees: Universidad Autonoma Metropolitana, Instituto Nacional de Neurologia Y Neurocirugia Manuel Velasco Suarez, Instituto Mexicano del Seguro Social, Instituto Nacional de Investigaciones NuclearesInventors: Roberto Olayo Gonzalez, Juan Morales Corona, Rodrigo Lozano Mondragon, Ana Laura Alvarez Mejia, Juan Carlos Axayacatl Morales Guadarrama, Luis Camilo Rios Castañeda, Maria de los Angeles Araceli Diaz Ruiz, Guillermo Jesús Cruz Cruz, María Guadalupe Olayo González, Hermelinda Salgado Ceballos
-
Patent number: 8552088Abstract: A cement for dental use, containing a first agent and a second agent, wherein both of the first agent and the second agent contain a polymerizable monomer (a) and a filler (b), wherein the first agent and/or the second agent further contains a photopolymerization initiator (c), wherein further as a chemical polymerization initiator (d), either one of the first agent and the second agent contains an oxidizing agent (f) and the other contains a reducing agent (g), the oxidizing agent (f) and the reducing agent (g) constituting a redox polymerization initiator, wherein the photopolymerization initiator (c) contains an ?-diketone, and the photopolymerization initiator (c) is contained in a total amount of from 0.010 to 0.100 parts by weight, based on 100 parts by weight of the total amount of the polymerizable monomer (a), wherein the chemical polymerization initiator (d) is contained in a total amount of from 0.Type: GrantFiled: December 25, 2008Date of Patent: October 8, 2013Assignee: Kuraray Noritake Dental Inc.Inventors: Hiroki Shinoda, Mitsuru Takei, Hidemi Nakayama
-
Patent number: 8552139Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.Type: GrantFiled: May 31, 2012Date of Patent: October 8, 2013Assignee: Bezwada Biomedical LLCInventor: Rao S Bezwada
-
Patent number: 8546462Abstract: A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.Type: GrantFiled: June 30, 2011Date of Patent: October 1, 2013Assignee: DePuy Synthes Products, LLCInventors: Andreas Boger, Christoph Sattig, Stefan Deusser
-
Patent number: 8530057Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: GrantFiled: May 12, 2009Date of Patent: September 10, 2013Assignees: The General Hospital Corporation, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
-
Patent number: 8524798Abstract: Compositions for use in treating and repairing orthopedic defects are provided. The compositions are especially useful for performing percutaneous vertebroplasty, percutaneous kyphoplasty and other procedures. When cured, the compositions are relatively solid but compressible, and prior to curing are viscous liquids with a low enough viscosity to fill voids in cavities such as voids within fractured vertebrae. Optionally, the properties of a composition according to the invention can be adjusted taking into account the hardness and density of the orthopedic structure to be repaired. Also disclosed are devices and methods for using the compositions, and a kit containing components for forming and utilizing the composition.Type: GrantFiled: September 25, 2007Date of Patent: September 3, 2013Inventors: Linda M. Trebing, Ralph W. Carmichael
-
Patent number: 8519019Abstract: The invention relates to dental compositions which can be used to produce dental prostheses and for dental restoration.Type: GrantFiled: December 17, 2002Date of Patent: August 27, 2013Assignee: Bluestar Silicones France SASInventors: Didier Dhaler, Jean-Marc Frances
-
Patent number: 8507578Abstract: Methods of producing a composite block intended for the production of a dental prosthesis including the following steps: a) impregnating a porous support with a liquid resin and b) curing the liquid resin impregnating the support are provided. In such methods of producing a composite block intended for the production of a dental prosthesis, a volume of liquid resin that is greater than the volume of the open pores of the support by at least 2% is caused to penetrate into the support and to cure therein, said volumes being measured at a temperature of 20° C. and at a pressure of 1 bar.Type: GrantFiled: September 11, 2009Date of Patent: August 13, 2013Inventor: Michael Sadoun
-
Publication number: 20130197628Abstract: Copolymer-modified nanoparticles produced by a process in which nanoparticles are ablated by laser radiation from a surface of a substrate in a liquid include an amphiphilic copolymer.Type: ApplicationFiled: April 19, 2011Publication date: August 1, 2013Applicants: AESCULAP AG, Max Planck Gesellschaft zur Foerderung der Wissenschaften e.V., LASER ZENTRUM HANNOVER E.V.Inventors: Stephan Barcikowski, Christin Menneking, Markus Klapper, Klaus Müllen, Michael Hoffmann, Simon Stelzig, Dennis Langanke, Helmut Goldmann
-
Publication number: 20130190699Abstract: An anti-biofilm catheter comprising a tubing configured to be disposed within a luminal system, wherein the tubing comes in contacting engagement with a blood flow within the luminal system in vivo. The catheter comprises a surface disposed over at least a portion of the tubing, wherein the surface comprises a surface profile having a skewness value of from about ?0.01 to about ?0.6 such that few or no components of the blood flow is capable of attaching themselves to the surface to encourage biofilm formation. The surface profile further comprises a kurtosis value of from about 2.7 to 3.3.Type: ApplicationFiled: January 20, 2012Publication date: July 25, 2013Inventor: Rabie Stephan
-
Patent number: 8487017Abstract: An implantable orthopedic medical device is disclosed. The medical devices is formed from a biodegradable polymer stereocomplex comprising a biodegradable polymer including a first enantiomer and a second enantiomer, wherein the implantable medical device initially degrades at a first degradation rate and subsequently degrades at a second degradation rate that is faster than the first degradation rate.Type: GrantFiled: June 27, 2011Date of Patent: July 16, 2013Assignee: Covidien LPInventors: Nadya Belcheva, Joshua Stopek
-
Publication number: 20130178555Abstract: The present invention provides optic portions, intraocular lenses, and polymers for use in manufacturing optic portions and intraocular lenses. The optic portions include a polymer that comprises (a) one or more alkoxyalkyl methacrylate monomers and/or one or more alkoxyalkyl acrylate monomers that are incorporated in the polymer; (b) one or more hydroxyalkyl methacrylate monomers and/or one or more hydroxyalkyl acrylate monomers that are incorporated in the polymer; and (c) optionally, one or more crosslinking agents that are incorporated in the polymer.Type: ApplicationFiled: November 19, 2012Publication date: July 11, 2013Applicant: Benz Research and Development CorporationInventor: Benz Research and Development Corporation
-
Patent number: 8465772Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: May 15, 2012Date of Patent: June 18, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
-
Patent number: 8465773Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: May 15, 2012Date of Patent: June 18, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
-
Patent number: 8461227Abstract: A composition of macrocyclic oligomer with at least one polymerizable group, (meth)acrylate, for example.Type: GrantFiled: January 4, 2010Date of Patent: June 11, 2013Assignee: DENTSPLY International Inc.Inventors: Xiaoming Jin, Paul D. Hammesfahr
-
Publication number: 20130143325Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.Type: ApplicationFiled: April 8, 2011Publication date: June 6, 2013Applicant: AXCELON BIOPOLYMERS CORPORATIONInventors: Wankei Wan, Donna Padavan
-
Patent number: 8455565Abstract: Dental compositions and disulfide monomers are described. The disulfide monomer comprise a disulfide backbone group wherein each of the sulfur atoms are bonded to an ethylenically unsaturated group via a divalent linking group and the linking group comprises at least one heteroatom; and at least one other monomer ethylenically unsaturated monomer.Type: GrantFiled: May 18, 2011Date of Patent: June 4, 2013Assignees: 3M Innovative Properties Company, The Regents of the University of ColoradoInventors: Ahmed S. Abuelyaman, Joel D. Oxman, Yizhong Wang, Christopher N. Bowman, Hee Young Park, Christopher J. Kloxin
-
Patent number: 8455564Abstract: A dental composition of the present invention includes: a polymerizable monomer component (A); and an amorphous filler (B) having an average particle size of 1 to 20 ?m and including silica-based fine particles and coatings of an oxide that cover the surfaces of the silica-based fine particles. The oxide contains a zirconium atom, a silicon atom, and an oxygen atom. The dental composition contains 20 to 500 parts by weight of the filler (B) per 100 parts by weight of the polymerizable monomer component (A). The dental composition has a viscosity of 10 to 800 Pa·s. It is preferable that the filler (B) contain spherical particles, and that the percentage of the spherical particles in the filler (B) be at least 60%.Type: GrantFiled: April 28, 2009Date of Patent: June 4, 2013Assignees: Kuraray Noritake Dental Inc., JGC Catalysts and Chemicals Ltd.Inventors: Yoshiko Kuboe, Masaki Okubayashi, Koichi Okada, Keisuke Ohtsuka
-
Patent number: 8454689Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties and; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer are disclosed.Type: GrantFiled: December 18, 2009Date of Patent: June 4, 2013Assignee: Bausch & Lomb IncorporatedInventors: David Paul Vanderbilt, Paul L. Valint, Jr.
-
Patent number: 8440618Abstract: The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA.Type: GrantFiled: January 19, 2012Date of Patent: May 14, 2013Assignees: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, The Trustees of Princeton University, The Texas A&M University SystemInventors: Suzanne A. Maher, Jeffrey Schwartz, Axel Oscar Magnus Hook, Brooke Hageman Russell, Casey Marie Jones
-
Patent number: 8440739Abstract: A dental composition of the present invention includes: a polymerizable monomer (A); an amorphous filler (B) having an average particle size of 1 to 20 ?m and including silica-based fine particles and coatings of an oxide that cover the surfaces of the silica-based fine particles; and inorganic particles (C) having an average particle size of 0.1 to 1.0 ?m. The oxide contains a zirconium atom, a silicon atom, and an oxygen atom. It is preferable that the dental composition contain 50 to 400 parts by weight of the filler (B) and 100 to 400 parts by weight of the inorganic particles (C) per 100 parts by weight of the polymerizable monomer (A).Type: GrantFiled: April 28, 2009Date of Patent: May 14, 2013Assignees: Kuraray Noritake Dental Inc., JGC Catalysts and Chemicals Ltd.Inventors: Masaki Okubayashi, Koichi Okada, Yusuke Takahata, Keisuke Ohtsuka
-
Patent number: 8440737Abstract: The invention relates to a composition for injectable cement, comprising a mineral sold phase, a separate liquid phase and, optionally, microparticles of a biocompatible and biodegradable polymer. The mineral solid phase comprises a mixture of powders with the molar composition: (CP)6 (CaO)y (SrCO3)z, [CP being CaHPO42H2O, CaHPO4, Ca1-xSrxHPO4, an equimolar mixture of bis(Ca(H2PO4)2, H2O and CaO, or a mixture of two or three of said compounds] and y+z=4?1. The liquid phase comprises pure apyrogeneic water or a saline aqueous solution with pH 4 to 9. The ratio L/P [volume of liquid phase/mass of solid mineral phase] is at least 0.4 ml/g. The above is of application as bone replacement.Type: GrantFiled: April 29, 2005Date of Patent: May 14, 2013Assignees: Centre National de la Recherche Scientifique, Universite de Montpellier 1Inventors: Philippe Boudeville, Michel Vert, Sylvie Munier
-
Patent number: 8436201Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: GrantFiled: September 5, 2012Date of Patent: May 7, 2013Assignee: Bezwada Biomedical, LLCInventor: Rao S Bezwada
-
Patent number: 8436070Abstract: The present invention relates to a material for dental products comprising a mixture of at least one polymerizable monomer and at least one polymer based on polysulfones which is preswollen in a portion of the polymerizable monomer.Type: GrantFiled: June 30, 2009Date of Patent: May 7, 2013Assignee: Ivoclar Vivadent AGInventors: Volker Rheinberger, Axel Kammann
-
Patent number: 8436071Abstract: The invention is directed to an improved dental composition useful in the repair of cavities, apex repairs, root perforations and root canals. Disclosed is a dental composition and dental composition additive which have improved handling characteristics, for example improved viscosity and setting time. The addition of effective amounts of a modified cellulose and calcium chloride to available dental repair compounds, such as mineral trioxide compound, results in the improved dental composition without affecting the other characteristics of the dental repair compound.Type: GrantFiled: October 3, 2011Date of Patent: May 7, 2013Assignee: Saint Louis UniversityInventors: John F. Hatton, Benjamin S. Ber, Gregory P. Stewart
-
Publication number: 20130109779Abstract: Polymeric and co-polymeric compositions useful for preparing ophthalmic and ocular devices, such as implantable intraocular lenses (IOL) and contact lenses, and processes of forming the compositions and devices are provided. The disclosed polymeric or co-polymeric composition may include a curcuminoid compound as a UV-blocker, and is derived from a pre-polymerization mixture of monomers which comprises at least 50 weight percents acrylate monomers and exhibiting visible light transparency and ultraviolet light opacity. The disclosed co-polymeric composition may alternatively, or in addition, be derived from a pre-polymerization mixture of defined monomers.Type: ApplicationFiled: July 5, 2011Publication date: May 2, 2013Applicant: POLYMER TECHNOLOGIES INTERNATIONAL (EOU)Inventors: Sanjay Ram Swaroop Argal, Munavvar Tahir Hussain, Vinod Chintamani Malshe, Abhijit Bhagvat Patil
-
Patent number: 8431060Abstract: The invention provides a method of manufacturing a polymeric implantable medical device using gel extrusion of high molecular weight polymers or charge-induced orientation to avoid heat degradation of the polymer that might occur during conventional heat extrusion.Type: GrantFiled: September 14, 2009Date of Patent: April 30, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Bin Huang, David C. Gale
-
Patent number: 8431627Abstract: The present invention provides a composition for crown material including resin and a fine spherized composite glass powder. The fine composite glass powder of the present invention for such a configuration has superior qualities with regard to both sintering and optical characteristics, and can be used as a filler for crown material.Type: GrantFiled: August 14, 2009Date of Patent: April 30, 2013Assignee: Sukgyung AT Co., Ltd.Inventors: Hyung Sup Lim, Hyung Joon Lim, Young Cheol Yoo, Sang Heon Kang, Jeong Won Seo
-
Patent number: 8426489Abstract: Present embodiments include composite dental materials for use in fillings and crowns, and methods of making the same. The composite materials can include biocompatible dental resin matrices and filler materials. The filler materials can include various types of magnetic nanoparticles. Additional embodiments include method of forming composite dental materials using a magnetic field and methods for forming aluminum oxide (Al2O3) nanoparticles. Other embodiments according to present teachings include methods for filling dental cavities and forming dental crowns.Type: GrantFiled: December 15, 2009Date of Patent: April 23, 2013Assignee: STC.UNMInventors: Marwan S. Al-Haik, Tariq A. Khraishi
-
Patent number: 8425815Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.Type: GrantFiled: August 18, 2006Date of Patent: April 23, 2013Assignee: The General Hospital CorporationInventors: Orhun K. Muratoglu, Ebru Oral