Abstract: The invention relates to an orthopaedic implant made of a ceramic metal composite. The composite includes one phase that is a biocompatible metal or metal alloy and a second phase of ceramic particles examples of which include carbides, nitrides and/or oxides. In some embodiments, the implant comprises a homogeneous ceramic layer as part of a multilayered composition. In some embodiments, the multilayered composition comprises a homogeneous metal layer.

Abstract: The invention relates to a method for preparing a cross-linked sterile and homogeneous hydrogel for injection, characterized in that it comprises the following steps: (a) preparing an aqueous solution containing a polymer derived from cellulose and at least one water-soluble polymer, the total polymer content ranging from 0.5 and 5 wt %, preferably from 1 to 4 wt % and more preferably from 1.5 to 3 wt %; (b) optionally adding sold particles; (c) pouring the resulting liquid mixture with the optional solid particles into a vessel and closing dais vessel using a water-tight and gas-tight system; and (d) exposing said vessel containing the liquid and the optional solid particles to a radiation dose of between 5 and 50 kGy, preferably between 20 and 30 kGy, and more preferably of about 25 kGy. The invention also relates to a hydrogel obtained according to the above method and to the use thereof in medical applications.

Abstract: An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing material 10 according to the present invention comprises molding a substrate 12 containing a radical scavenger and a polymer material; washing at least a part 16 of the substrate 12 with a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the part 16 of the surface after washing so as to form a polymer film 30 on at least the part of the surface.

Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Abstract: The present invention provides a polymerizable composition that is suitably used as a temporary cement for implant use and a mobile tooth-fixing material. The present invention is a polymerizable composition that includes an acrylic block copolymer (a) having at least one polymer block A that mainly contains a (meth)acrylic acid ester unit and that functions as a hard segment and at least one polymer block B that mainly contains an acrylic acid ester unit and that functions as a soft segment, a polymerizable monomer (b), and a polymerization initiator (c).

Abstract: The present application provides a glass composition comprising 10-50% by weight CaO, at least 15% and less than 50% by weight P2O5, less than 3% by weight Al2O3, less than 10% by weight Li2O, Na2O, and K2O combined, and 0-60% by weight of SrO, MgO, BaO, ZnO, or combinations thereof; dental compositions comprising the glass composition, and methods of making and using such dental compositions.

Abstract: A composite material and method of making and using the same is described. In particular a dental (and preferably photocurable) composite material, and the use of a composite material according to the invention as a dental material and a method for preparation of a composite material according to the invention. Also disclosed are novel radically polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a composite material according to the invention.

Abstract: Provided herein is a curable silicone composition that has high optical transparency after being cured and that is in a putty form to be hand-mixable. A curable silicone composition contains: a specific organopolysiloxane as a component (1); a specific organohydrogenpolysiloxane as a component (2); a filler as a component (3); and a catalyst as a component (4). The difference between the refractive index of one of the components (1) to (3) that has the highest refractive index and the refractive index of one of the components (1) to (3) that has the lowest refractive index is 0.1000 or less. The complex viscosity of any of constituent compositions of the curable silicon composition before the curable silicone composition is cured is 10 Pa·s to 100000 Pa·s, as measured under predetermined measurement condition.

Abstract: Hardenable compositions are described comprising at least one multifunctional ethylenically unsaturated isocyanurate monomer and at least one multifunctional ethylenically unsaturated tricyclodecane monomer. In favored embodiments, the compositions further comprise filler and are suitable dental restorations.

Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.

Abstract: The invention provides a high strength dental composition including polymerizable dental resins. The dental composition is useful as restorative material and for making various dental devices, such as artificial teeth, crowns and bridges of high strength dental polymeric material.

Abstract: A dental composite composition is disclosed that includes a polymerizable resin, filler particles, and at least one polymerizable stable radical. A variety of polymerizable stable radicals may be employed, including those that have a 2,2,6,6-tetramethylpiperidinyl-1-oxyl moiety. Compositions as described herein exhibit excellent mechanical strength, hardness, and flexural modulus, while also significantly decreasing shrinkage stress caused by polymerization.

Abstract: The present disclosure relates to a multi-modal shape memory polymer material comprising a blend of at least one polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component.

Abstract: A dual-cure curable material kit comprising: (A) a radical-polymerizable monomer component; (B) a photopolymerization initiator component comprising (b1) an ?-diketone compound, (b2) an aliphatic tertiary amine compound having a tertiary amino group in which three saturated aliphatic groups are bonded to a nitrogen atom and one of the saturated aliphatic groups has an electron-withdrawing group as a substituent, and (b3) an s-triazine compound having a trihalomethyl group as a substituent, or a diaryliodonium salt compound; and a chemical polymerization initiator component (C) comprising (c1) an organic peroxide, and (c2) an N,N-di(hydroxyalkyl)-p-toluidine compound; which is packed separately at least in two packages so that the component (b2) and the component (b3) of the photopolymerization initiator component (B) are not packed together in a single package and the component (c1) and the component (c2) of the chemical polymerization initiator component (C) are not packed together in a single package.

Abstract: The invention relates to a hardenable dental composition comprising component (A) comprising a cationically hardenable compound, component (B) comprising an initiator being able to initiate the hardening reaction of the cationically hardenable compound, and component (C) comprising a filler, wherein the filler comprises a filler body and a filler surface, the filler surface comprising side groups with polar moieties. The invention also relates to a process of producing the dental composition, to the use of the dental composition as dental impression material and to a method of taking an impression of dental tissue.

Abstract: A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of binding to tissue. The sprayable material also possesses functional groups capable of binding to an implant. In embodiments, the functional groups capable of binding to an implant include nucleotides. In such a case, the implant possesses complementary nucleotides capable of binding to the nucleotides on the sprayable material, thereby permitting hydrogen binding between the two. The implant may thus be affixed to tissue, and repositioned as necessary, prior to more permanent attachment utilizing means such as sutures, tacks, etc.

Abstract: A hydroxyapatite ceramic hybrid material includes a hydroxyapatite ceramic structure having pores therein and a biodegradable polymer included in the pores in the hydroxyapatite ceramic structure. The biodegradable polymer can be a poly L-lactic acid polymer. A method for preparing a hydroxyapatite ceramic-biodegradable polymer hybrid material includes preparing a porous hydroxyapatite ceramic containing pores having an average pore diameter of 10 ?m or larger; and forming a biodegradable polymer in the pores of the porous hydroxyapatite ceramic. The porous hydroxyapatite ceramic may be prepared by: preparing a slurry comprising hydroxyapatite fibers and heat-degradable particles in a selected solvent; filtering the slurry to obtain a paste; preparing a molded body using the paste; compacting the molded body to produce a green compact; and firing the green compact at a temperature at least 1000° C. to produce a porous hydroxyapatite ceramic structure.

Abstract: The invention relates to a curable dental composition comprising a curable polyether group containing polymer as component (A), an initiator capable of initiating a curing reaction of component (A) as component (B) and a certain F-containing compound as component (C). The invention also relates to a method of production and use of the curable dental composition or a respective kit of parts for the preparation of or as impression material or for the preparation of crowns and bridges.

Abstract: The invention includes a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. The system of the invention has enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems.

Abstract: The present application provides dental compositions, and methods of making and using dental compositions that include a calcium and phosphorus releasing glass. Such dental compositions can be useful for delivering ions to the oral environment.

Abstract: Disclosed is a dental composition, comprising unsaturated double bond-containing monomers and/or oligomers, a catalytic amount of polymerization initiator to initiate polymerization, and a filler, wherein the dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material to inhibit or prevent tooth decay. The dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material, thus uniformly and continuously exhibiting anticariogenic and antibacterial activities, while avoiding deterioration in physical properties required for the dental material.

Abstract: The invention relates in various embodiments to a composite useful as e.g. a medical implant device, and a method of treating fouling, including biofouling as may occur on an implant. The composite comprises a matrix phase and a patterned phase that comprises an energetically activatable wire intermixed with the matrix phase, the wire when energetically activated, which includes thermal activation, causes modification of at least a portion of the matrix phase to treat fouling that might otherwise occur. The method of treating biofouling may be practiced on a patent while the medical implant of the invention is in situ.

Abstract: A method of making capsules includes forming a mixture including a core liquid, a polyurethane precursor system, a first component of a two-component poly(urea-formaldehyde) precursor system, and a solvent. The method further includes emulsifying the mixture, adding a second component of the two-component poly(urea-formaldehyde) precursor system to the emulsified mixture, and maintaining the emulsified mixture at a temperature and for a time sufficient to form a plurality of capsules that encapsulate at least a portion of the core liquid. The capsules made by the method may include a polymerizer in the capsules, where the capsules have an inner capsule wall including a polyurethane, and an outer capsule wall including a poly(urea-formaldehyde). The capsules may include in the solid polymer matrix of a composite material.

Abstract: The present invention discloses a kit of material for dentin restoration including a combination of a plurality of kinds of curable pastes each having a different hue, wherein each of the curable pastes exhibits L* of 55 to 75 and a fluctuation range of L* of 3 or less in a CIELab color system when the color of a cured body with a thickness of 3.0 mm obtained by curing the pastes is measured against a black background, and a method for producing the kit of material for dentin restoration.

Abstract: The composition for hard tissue repair of the present invention is characterized by comprising 5 to 98.95 parts by weight of a monomer (A), 1 to 75 parts by weight of a (meth)acrylate polymer (B) and 0.05 to 20 parts by weight of a polymerization initiator composition (C) containing an organoboron compound (c1), with the proviso that the total amount of the components (A), (B) and (C) is 100 parts by weight. The composition undergoes small-scale heat generation during curing and can ensure a sufficient working time.

Abstract: Provided are: an organic/inorganic composite, and a manufacturing method therefor; and a dental material and bone substitute material manufactured using the organic/inorganic composite. The organic/inorganic composite includes: (A) 100 parts by mass of a thermoplastic resin containing as a main component at least one kind selected from a polyarylketone resin and a polysulfone resin; and (B) 60 to 300 parts by mass of an inorganic particle mixture dispersed in the thermoplastic resin, in which the inorganic particle mixture contains inorganic particles each having a particle diameter of from 200 to 700 nm at a content of 25 vol % or more, and inorganic particles each having a particle diameter of from 40 to 100 nm at a content of 10 vol % or more.

Abstract: The invention relates to a radically polymerizable monomer of formula (I) wherein W1 and W2 in each case independently represent H or X—R—Y—PG, wherein at least one of W1 and W2 represents X—R—Y—PG, X in each case independently is missing or represents an ether, ester, amide, urethane or urea group, Y in each case independently is missing or represents an ether, ester, amide, urethane or urea group, R in each case independently is missing or represents a C1-C16 alkylene radical which can be interrupted by one or more O atoms, wherein R can be missing only if X and/or Y is simultaneously also missing, and PG in each case independently represents a cyclic, ring-opening polymerizable group, a, b, c and d independently of each other can take the values 3 to 10.

Abstract: Presently described are curable dental compositions comprising a polymerizable ionic liquid. The polymerizable ionic liquid comprises one or more ethylenically unsaturated (e.g. free-radically polymerizable) groups. Various embodiments of curable dental compositions are described. In some embodiments, the polymerizable ionic liquid is a monofunctional polymerizable ionic liquid comprising an ethylenically unsaturated group. In other embodiments, the polymerizable ionic liquid is a multifunctional polymerizable ionic liquid comprising at least two ethylenically unsaturated groups. The curable dental compositions describe herein can be utilized as dental primers, dental adhesives, dental sealants, and dental composites. In many embodiments, the curable dental compositions further comprise an initiator such as a photoinitiator.

Abstract: Improvedly storage stable dental compositions useful for the preparation of dental prostheses and for dental restoration containing a uniquely pretreated dental filler material.

Abstract: The disclosed subject matter can provide a nanotube-reinforced polymer composite material comprising a plurality of nanotubes, each nanotube being formed of a plurality of cyclic peptide molecules, disposed within a polymer matrix, such as a biodegradable polymer matrix. A cyclic polymer, such as a cyclic 8-mer, composed of amino acid residues of alternating absolute configurations (D/L, R/S), can self-assemble into nanotubes useful for preparation of the composite polymer material of the invention. For example, the cyclic peptide (QL)4, wherein the glutamine and leucine residues are of opposite absolute configuration, self-assembles into nanotubes, which when formed into a reinforced polymer composite including poly(caprolactone), provides a biocompatible material of greater tensile strength and Young's modulus compared to the poly(caprolactone) material alone. The nanotubes can be prepared by a vapor equilibration technique or by a solvent-nonsolvent precipitation technique.

Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.

Abstract: The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold.

Abstract: Provided are: a resin composite, which is produced using: 100 parts by mass of a resin having a melting point or fluidization temperature of from 200 to 500° C.; and 40 to 400 parts by mass of inorganic particles surface-treated with a treatment-agent having a reactive double bond group or an aromatic group at an end thereof, the resin composite having an rate of 55% or more a manufacturing method for the resin composite; and a dental material using the resin composite: And the rate (%) represents 100×{EP/(EP+V)}; EP represents the number of the inorganic particles per square region measuring 10 ?m on each side exposed in a polished surface of the resin composite; and V represents the number of voids per square region measuring 10 ?m on each side formed through elimination of the inorganic particles in the square region where the EP is counted.

Abstract: Curable dental compositions, dental articles, and methods of making or using such compositions or articles are described. In one embodiment, the curable dental restoration composition comprises a resin system comprising a free-radically polymerizable semi-crystalline resin having a molecular weight no greater than 3000 g/mole and at least 50 wt-% of nanocluster filler.

Abstract: A method for producing core-shell type particles, including: ring-opening polymerizing a ring-opening polymerizable monomer in a first mixture containing the ring-opening polymerizable monomer, porous particles, and a compressive fluid; and injecting a second mixture containing a polymer obtained in the ring-opening polymerizing, the porous particles, and the compressive fluid to thereby granulate into the core-shell type particles.

Abstract: Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-?Caprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.

Abstract: A method for making a composite material with non-spherical reinforcing particles embedded in a matrix, is disclosed. In this method, in a first step magnetic and/or superparamagnetic nanoparticles are attached to the non-spherical reinforcing particles, in a second step the resulting reinforcing particles are introduced into a liquid matrix material and/or a liquid matrix-precursor material, and in a third step the material of the matrix is solidified and/or polymerized and/or cross-linked. In accordance with the proposed invention prior to and/or during solidification and/or polymerization and/or cross-linking of the matrix material or the matrix precursor material, respectively, a magnetic field is applied so as to align the reinforcing particles in the matrix and this alignment is fixed in the matrix during and after the third step, wherein the non-spherical reinforcing particles preferably have a length (l) in one dimension of at least 0.

Abstract: The present invention relates to a dental material comprising, relative to the total mass of the material: (a) 1 to 95 wt.-% of at least one polymerizable N,O-functionalized acrylic acid hydroxamide, (b) 0 to 70 wt.-% diluent monomer, (c) 0 to 70 wt.-%, cross-linker monomer, (d) 0.1 to 5.0 wt.-% polymerization initiator (e) 0 to 80 wt.-% filler, (f) 0 to 70 wt.-% solvent, and (g) 0 to 70 wt.-% adhesive monomer.

Abstract: The subject matter of the invention is a radically polymerizable dental material comprising at least two components. A first component of the dental material contains the salt of a CH-acidic compound, and an additional component contains an acid with acidity greater than that of the CH-acidic compound of the first component. Both components contain radically polymerizable monomers. When the two components are mixed, the acid of the second component converts the salt of the CH-acidic compound of the first component into a CH-acidic molecule, and the CH-acidic molecule triggers the radical polymerization of the monomers. In addition to the advantages of CH-acidic compounds in dental materials on the basis of a reactive resin, the invention achieves long-term storage stability as a result of an increase in the proportion of the reactive resin matrix in polymerizable dental materials.

Abstract: A biocompatible implantable bone anchor is provided that has a threaded first portion that engages and anchors into a bone. The implant also has a neck region extending from the first portion adapted to promote autologous cell growth thereon at an interface of the bone and one or more epidermal or gum layers, the neck region having a plurality of channels extending about the neck region. The neck region is configured to mechanically engage at least one of an abutment, dental restoration, or osseous device attachment. An in situ bone anchor cell growth assembly includes the bone anchor and a manifold encompassing the neck portion so as to form a seal therebetween and a route of fluid communication between a manifold inlet and at least one of said plurality of channels. A process for growing autologous cells on a neck region of a bone anchor is provided.

Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.

Abstract: A novel nanocomposite having graphene sheets is described. The nanocomposite may be used for medical devices such as bone cement, dentures, paper, paint and automotive industries. A novel Microwave irradiation (MWI) was used to obtain R-(GO-(STY-co-MMA)). The results indicate that the nanocomposite obtained using the MWI had a better morphology and dispersion with enhanced thermal stability compared with the nanocomposite prepared without MWI. An average increase of 136% in hardness and 76% in elastic modulus were achieved through the addition of only 2.0 wt % of RGO nanocomposite obtained via the MWI method.

Abstract: The present invention relates to pharmaceutical compositions comprising one or more amphiphilic polymer lubricants for use in association with artificial orthopaedic implants. Additionally, the invention relates to medical use of the lubricants of the invention in connection with conditions associated with artificial orthopaedic implants. The invention furthermore relates to artificial joint implants comprising the polymer lubricants according to the invention and methods for preparing such implants.

Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. Alternatively, the kit comprises ready-to-use means for carrying out the method of infiltrating enamel, e.g. application strips with delivery pads soaked with conditioner or infiltrant. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.

Abstract: The present invention relates to a process for the preparation of particularly reactive and low-viscosity reaction products of polyisocyanates which contain activated ethylenically unsaturated groups which react by polymerization under the action of actinic radiation, and the use of these reaction products in coating compositions, and particularly scratch-resistant coatings obtainable therefrom.

Abstract: An article comprising two chemically grafted polymer layers comprising a hydrogel layer and an end-functionalized polyurethane layer. The invention also includes methods of making and using the article.

Abstract: One-component heat-curable sealant composition for the protection of exposed dental surfaces, comprising (a) a polymerizable monomer and/or oligomer which has at least two polymerizable double bonds per molecule, and (b) an initiator system comprising benzoylperoxide in an amount of at least 2 wt.-% based on the total composition.

Abstract: A fiber wadding for filling bone defects having a flocculent three-dimensional structure is disclosed. The fiber wadding includes a plurality of fibers that contain a biodegradable resin as a principal component and a siloxane. Outside diameter of the plurality of fibers of the wadding is from about 0.05 ?m to about 30 ?m. Bulk density of the fiber wadding is about 0.005-0.3 g/cm3.

Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z?CH2COO— where z? is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R? is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

Abstract: Described herein is a dental filler material having a core made of a core material and a shell made of a shell material, where the shell material coats or covers at least a portion of the core.