Processes Patents (Class 536/124)
  • Patent number: 11084797
    Abstract: The invention relates to a process for converting a feedstock comprising at least one sugar into 5-hydroxymethylfurfural, wherein said feed is brought into contact with one or more inorganic dehydration catalysts and one or more chloride sources in the presence of at least one aprotic polar solvent alone or as a mixture, at a temperature of between 30° C. and 200° C., and at a pressure of between 0.1 MPa and 10 MPa.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 10, 2021
    Assignee: IFP Energies nouvelles
    Inventors: Justine Denis, Marc Jacquin, Damien Delcroix
  • Patent number: 11078173
    Abstract: The invention relates to a novel process for converting a feedstock comprising at least one sugar into 5-hydroxymethylfurfural, wherein said feedstock is brought into contact with one or more organic dehydration catalysts and one or more chloride sources in the presence of at least one aprotic polar solvent alone or as a mixture, at a temperature of between 30° C. and 200° C., and at a pressure of between 0.1 MPa and 10 MPa.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 3, 2021
    Assignee: IFP Energies nouvelles
    Inventors: Justine Denis, Marc Jacquin, Damien Delcroix
  • Patent number: 11067569
    Abstract: The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: July 20, 2021
    Assignee: MCMASTER UNIVERSITY
    Inventors: Carlos Filipe, John D. Brennan, Robert Pelton, Sana Jahanshahi-Anbuhi, Yingfu Li
  • Patent number: 11066558
    Abstract: The present invention relates to an asphalt composition enabling one to provide an asphalt pavement in which the occurrence of rutting and fatigue cracking is inhibited and a method for producing the same, and to an additive for asphalt. The asphalt composition contains asphalt and cellulose, wherein the content of the cellulose is 0.01 part by mass or more and 10 parts by mass or less based on 100 parts by mass of the asphalt, and a crystallization index of the cellulose is 50% or less.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: July 20, 2021
    Assignee: KAO CORPORATION
    Inventors: Kazutomo Osaki, Keiko Fukaya, Tomoya Wada, Kohei Yamada
  • Patent number: 11034713
    Abstract: A process for the preparation of C4 oxygenate compounds such as threose, erythrose or erythrulose starting from a composition comprising C1-3 oxygenate compounds such as formaldehyde, glycolaldehyde, glyoxal, pyruvaldehyde or acetol, wherein the process is carried out in the presence of a crystalline microporous material having a ring pore structure selected from an eight-membered ring pore structure or a ten-membered ring pore structure.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: June 15, 2021
    Assignee: Haldor Topsoe A/S
    Inventors: Saravanamurugan Shunmugavel, Irantzu Sadaba Zubiri, Esben Taarning, Martin Spangsberg Holm
  • Patent number: 11020512
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: June 1, 2021
    Assignee: ALLERGAN INDUSTRIE, SAS
    Inventor: Pierre F. Lebreton
  • Patent number: 10981135
    Abstract: The invention relates to a method for treating a nanofibrillar cellulose hydrogel, wherein the method comprises the steps of: providing a nanofibrillar cellulose hydrogel, wherein the nanofibrillar cellulose is oxidized nanofibrillar cellulose, wherein the oxidation has been carried out through N-oxyl mediated catalytic oxidation of cellulose-based raw material, and has at most 50 ?mol of aldehyde groups per gram of dry nanofibrillar cellulose; and subjecting the nanofibrillar cellulose hydrogel to a heat treatment.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 20, 2021
    Assignee: UPM-KYMMENE CORPORATION
    Inventor: Isko Kajanto
  • Patent number: 10934367
    Abstract: Provided is a method for producing HPMCAS capable of reducing the average particle size of HPMCAS particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose acetate succinate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension, a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate, and a drying step of drying the liquid-removed hypromellose acetate succinate.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 2, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Mitsuhiro Yoshida, Junichi Matsubara, Kazuki Kikuchi
  • Patent number: 10870710
    Abstract: This disclosure relates to synthetic oligosaccharide subunits of the Pseudomonas exosaccharide Psi and uses thereof, e.g., for epitope mapping of anti-Psl antibodies, for identification of anti-Psl antibodies, and for use as vaccines. In one aspect a synthetic oligosaccharide subunit of a Pseudomonas aeruginosa Psl oligosaccharide is provided, comprising the trisaccharide of formula I.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 22, 2020
    Assignees: MedImmune Limited, University of Georgia Research Foundation, Inc.
    Inventors: Antonio DiGiandomenico, Qun Wang, Charles K. Stover, Geert-Jan Boons, Kai-For Mo, Huiqing Li
  • Patent number: 10844141
    Abstract: The present invention relates to a process for obtaining polysaccharides from jatoba seeds, comprising the steps of: a) seed processing (dry process); b) aqueous extraction at 1% to 5% of powder mass per volume, preferably 2% of powder mass per volume; c) precipitation with ethanol 969GL using 1 to 3 times the aqueous extract volume; d) press filtration of the precipitate obtained in (c); e) solublization of the polysaccharides obtained in step (d) with water; and f) drying the polysaccharides obtained in step (e). In another embodiment, the present invention relates to a cosmetic composition containing polysaccharides obtained according to the process defined above and to the use of said polysaccharides.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: November 24, 2020
    Assignee: NATURA COSMÉTICOS S.A.
    Inventors: Pamela Araujo Rodrigues Muchiutti, Cintia Rosa Ferrari, César Gustavo Serafim Lisboa, Patrícia da Luz Moreira, Kelen Fabiola Arroteia, Vanessa de Moura Sá Rocha
  • Patent number: 10806825
    Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: October 20, 2020
    Assignee: SpineOvations, Inc.
    Inventors: Stuart Young, Neville Alleyne, Nicholas John Manesis
  • Patent number: 10736967
    Abstract: Aspects of the disclosure feature a method that comprises preparing an agent-cyclodextrin complex. Preparing the agent-cyclodextrin complex includes contacting a first composition comprising an agent with a porous cyclodextrin-metal organic framework to form a second composition comprising an agent-cyclodextrin-metal organic framework complex, the cyclodextrin-metal organic framework including a plurality of cyclodextrin molecules and at least one metal cation. Preparing the agent-cyclodextrin complex also includes dissolving the agent-cyclodextrin-metal organic framework complex in an aqueous solvent to form a third composition including the agent-cyclodextrin complex.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 11, 2020
    Assignee: PanaceaNano, Inc.
    Inventors: Benjie N. Limketkai, Youssry Y. Botros
  • Patent number: 10654887
    Abstract: The invention relates to a separation matrix comprising at least 11 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein: a) the ligands comprise multimers of alkali-stabilized Protein A domains, and b) the porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50,v) of 56-70 micrometers and a dry solids weight of 55-80 mg/ml.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 19, 2020
    Assignee: GE Healthcare Bio-Process R&D AB
    Inventors: Gustav Jose Rodrigo, Tomas Bjorkman, Mats Ander, Jesper Ulf Hansson
  • Patent number: 10577359
    Abstract: The present invention provides (i) processes for preparing a 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2?-deoxy-2?-fluoro-2?-C-methyl-ß-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: March 3, 2020
    Assignee: Gilead Pharmasset LLC
    Inventors: Byoung-Kwon Chun, Jinfa Du, Suguna Rachakonda, Peiyuan Wang
  • Patent number: 10485896
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: November 26, 2019
    Assignee: ALLERGAN INDUSTRIE SAS
    Inventor: Pierre F. Lebreton
  • Patent number: 10426184
    Abstract: Provided are methods of making high quality seaweed meal suitable for food applications. The method comprises the steps of cleaning the fresh, dried, or rehydrated red seaweed, pretreating the red seaweed with alkali, pre-treating the red seaweed with acid, hydrolyzing the red seaweed with cellulase, and drying and grinding the treated red seaweed to obtain the seaweed meal. The seaweed meal produced by the disclosed technology has light color, good flavor and taste, good mouthfeel, high gelling capability, great stability, and ideal smoothness and slipperiness suitable for food applications.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 1, 2019
    Assignee: NUTRIOMIX, INC.
    Inventor: Lijun Sun
  • Patent number: 10391202
    Abstract: Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 27, 2019
    Assignee: Allergan Industrie SAS
    Inventor: Pierre F. Lebreton
  • Patent number: 10311993
    Abstract: The present invention includes composition and methods for a core matrix comprising a dissolved cellulose fiber of, e.g., high molecular weight (DP>5000) or microcrystalline cellulose of low molecular weight (DP: 150-300), printed into a two or three dimensional pattern; a conductive material comprising a carbon nanotube or graphene oxide disposed on or about the cellulose fiber or microcrystalline cellulose; and an enhancer or stabilizer that stabilizes the dissolved cellulose or microcrystalline cellulose disrupted during a printing process, wherein the conductive material and the cellulose or microcrystalline cellulose forms one or more features in or on the cellulose fiber or microcrystalline cellulose.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 4, 2019
    Assignee: Texas Tech University System
    Inventors: Noureddine Abidi, Yang Hu
  • Patent number: 10239915
    Abstract: This invention is intended to produce a novel functional material through solubilization and molecular weight reduction of a water-insoluble polymeric compound, such as a water-insoluble protein or water-insoluble polysaccharide, in a simple and efficient manner.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: March 26, 2019
    Assignees: JELLYFISH RESEARCH LABORATORIES, INC., MARUWA OIL & FAT CO., LTD.
    Inventors: Satoshi Shinohara, Takayuki Baba, Koji Kihira
  • Patent number: 10179799
    Abstract: A method for producing P1,P4-di(uridine 5?-)tetraphosphate (UP4U) that can avoid reduction of the synthetic efficiency without using UTP free is developed. A method for producing UP4U comprising reacting a phosphoric acid-activating compound represented by formula [II] or [III] with a phosphoric acid compound selected from the group consisting of UMP, UDP, UTP and a pyrophosphoric acid or a salt thereof (excluding UTP free) in water or a hydrophilic organic solvent, in the presence of a metal ion selected from the group consisting of an iron (II) ion, an iron (III) ion, a trivalent aluminum ion, a trivalent lanthanum ion, and a trivalent cerium ion. where, in the formula [II], R1 represents a uridyl group binding to the 5?-position, X represents a heterocyclic group, and n represents an integer of 1 or 2, where, in the formula [III], X represents a heterocyclic group selected from the group consisting of an imidazolyl group, a benzimidazolyl group, and a 1,2,4-triazolyl group.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: January 15, 2019
    Assignee: YAMASA CORPORATION
    Inventor: Kohei Yamada
  • Patent number: 10131908
    Abstract: The present invention provides nucleosides and oligonucleotides comprising a 5? phosphate mimics of formula (IVc) or (Vc), One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: November 20, 2018
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Marija Prhavc, Ivan Zlatev
  • Patent number: 10100376
    Abstract: Methods are provided for the purification of isoidide. The methods comprise subjecting an at least partially deionized isoidide composition comprising isoidide and other isohexides to chromatographic separation of isoidide from other isohexides, removal of solvent from the isoidide, and crystallization of the isoidide. Isoidide of monomer-grade purity is obtained.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: October 16, 2018
    Inventors: Stephen Howard, Brennan Smith, Josh Terrian
  • Patent number: 10065910
    Abstract: The present disclosure relates generally to ceramic materials suitable for use as catalyst support materials, catalysts using such materials and methods for using them, such as methods for converting sugars, sugar alcohols, glycerol, and bio-renewable organic acids to commercially-valuable chemicals and intermediates. One aspect of the invention is a ceramic material including zirconium oxide and one or more metal oxides selected from nickel oxide, copper oxide, cobalt oxide, iron oxide and zinc oxide, the ceramic material being at least about 50 wt. % zirconium oxide. In certain embodiments, the ceramic material is substantially free of any binder, extrusion aid or additional stabilizing agent.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: September 4, 2018
    Assignee: Clariant Corporation
    Inventors: Wenqin Shen, Franz Petzold, Karen Libby, Wayne Turbeville, Matthew Purcell, Marc K. Born
  • Patent number: 10053397
    Abstract: The present disclosure relates generally to processes and systems for the hydrodeoxygenation of an oxygenate feedstock that increases the conversion of oxygenates to hydrocarbons while avoiding detrimental effects resulting from increasing the severity of the hydrodeoxygenation reaction.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: August 21, 2018
    Assignee: Phillips 66 Company
    Inventors: Alexandru Platon, Edgar Lotero Alegria
  • Patent number: 10005849
    Abstract: A process for producing a cellulose derivative, comprising: a first step including reacting a cellulose and a first reactant comprising a long-chain reactant for reacting with a hydroxy group of the cellulose to introduce a long-chain organic group having 5 or more carbon atoms, in a solid-liquid heterogeneous system, to form a cellulose derivative in a swollen state, the cellulose derivative having the long-chain organic group having 5 or more carbon atoms introduced therein and having a part of hydroxy groups of the cellulose remained, and performing solid-liquid separation to obtain the cellulose derivative as an intermediate; and a second step including reacting the intermediate cellulose derivative and a second reactant comprising a short-chain reactant for reacting with a remaining hydroxy group of the intermediate cellulose derivative to introduce a short-chain organic group having 4 or less carbon atoms to form a final cellulose derivative having the short-chain organic group having 4 or less carbon a
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: June 26, 2018
    Assignee: NEC Corporation
    Inventors: Kiyohiko Toyama, Masatoshi Iji, Shukichi Tanaka
  • Patent number: 9926384
    Abstract: This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: March 27, 2018
    Assignee: EASTMAN CHEMICAL COMPANY
    Inventors: Charles Buchanan, Norma Buchanan, Elizabeth Guzman-Morales
  • Patent number: 9927334
    Abstract: Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the disclosed hydrogel compositions are disclosed, including methods of utilizing the compositions in microfluidic devices.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: March 27, 2018
    Assignee: Northeastern University
    Inventors: Shashi K. Murthy, Adam Hatch, George Hansmann
  • Patent number: 9826768
    Abstract: A process for preparing an aqueous solution of a methylcellulose having anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups, comprises the step of mixing the methylcellulose with an aqueous liquid at a temperature of not higher than 10° C. at a shear rate of at least 1000 s?1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 28, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Puspendu Deo, Kathryn Brown, David E. Wallick, Robert L. Sammler, Yongfu Li
  • Patent number: 9693960
    Abstract: A method of controlling or adjusting release of an active ingredient from a dosage form comprising the active ingredient and a polysaccharide derivative has been found. The method comprises the steps of a) providing a composition comprising a polysaccharide derivative and a controlled amount of a liquid diluent, based on the dry weight of the polysaccharide derivative, b) subjecting the composition to a dry-grinding operation to provide a dry-ground polysaccharide derivative, and c) incorporating the dry-ground polysaccharide derivative and an active ingredient into a dosage form.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: July 4, 2017
    Inventors: Yvonne M. Goerlach-Doht, Juergen Hermanns, Nicholas S. Grasman
  • Patent number: 9688845
    Abstract: A method to produce an aqueous solution of carbohydrates containing C5- and/or C6-sugar-containing oligomers and/or C5- and/or C6-sugar monomers in which biomass or a biomass-derived reactant is reacted with a solvent system having an organic solvent, and organic co-solvent, and water, in the presence of an acid. The method produces the desired product, while a substantial portion of any lignin present in the reactant appears as a precipitate in the product mixture.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: June 27, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Ali Hussain Motagamwala
  • Patent number: 9637560
    Abstract: A reactive extrusion process for the production of substituted polysaccharides, in particular, cellulose acetate, starch acetate, carboxymethyl cellulose, and carboxymethyl starch.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: May 2, 2017
    Assignee: NUtech Ventures
    Inventors: Milford Hanna, Pratik Bhandari
  • Patent number: 9580516
    Abstract: When a combination of pulps having different alkali metal hydroxide solution absorption rates is as a raw material, contact conditions such as a contact temperature and a contact time have to be changed frequently, depending on the absorption rate of pulps currently processed, thereby causing a problem of reduced productivity. For solving the problem, provided is a method for producing alkali cellulose, comprising at least the steps of: bringing two or more types of pulps having different alkali metal hydroxide solution absorption rates into contact with an alkali metal hydroxide solution to obtain a contact product; and draining the contact product, wherein the highest absorption rate is not more than 4.0 times as fast as the lowest absorption rate.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: February 28, 2017
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Mitsuo Narita
  • Patent number: 9481738
    Abstract: Provided is a method for producing cellulose ether whose aqueous solution is transparent and contains a smaller amount of water-insoluble portion. The method comprises at least the steps of: providing at least two alkali cellulose materials having different compositions, each of the materials having been prepared by bringing a pulp into contact with a solution of alkali metal hydroxide and draining; and mixing the at least two alkali cellulose materials having different compositions, wherein each weight ratio of the alkali metal hydroxide in each of the alkali cellulose materials having different compositions to a solid component in the pulp (alkali metal hydroxide/solid component in pulp) is equal to 0.4 to 2.5 times of a weight ratio of alkali metal hydroxide in the alkali cellulose obtained in the step of mixing to solid components in a sum of pulps used for preparation of the alkali cellulose materials.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 1, 2016
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Mitsuo Narita
  • Patent number: 9464142
    Abstract: A process is disclosed for recovering pure cellulose from a cellulose-containing sludge, the process comprising treating a sludge cellulose source under conditions permitting dissolution of non-cellulose material and suspension of the cellulose, wherein said dissolution conditions do not alter cellulose morphology.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: October 11, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Oded Shoseyov, Arnon Heyman, Shaul Lapidot, Sigal Meirovitch, Yuval Nevo, Amit Rivkin
  • Patent number: 9428590
    Abstract: Reduction of the energy burden in a step of drying hydrous low-substituted hydroxypropyl cellulose (L-HPC), reduction of water content of a cake obtained by dehydration, and others are targeted. More specifically, provided is a method for dehydrating hydrous L-HPC with a compression type dehydrator by feeding the hydrous L-HPC to a screw conveyer connected to the inlet of the dehydrator, including steps of: starting the operation of the conveyer to fill the conveyer and the dehydrator with the hydrous L-HPC, starting the operation of the filled dehydrator, and feeding the hydrous L-HPC to the conveyer, while discharging dehydrated L-HPC from an outlet of the dehydrator, wherein a feed rate of feeding the hydrous L-HPC to the conveyer is equal to a discharge rate of discharging the dehydrated L-HPC in terms of net weight of cellulose ether, and a method for producing L-HPC by using the above method.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 30, 2016
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Junichi Matsubara, Atsuhiko Yonemochi, Mitsuo Narita
  • Patent number: 9371399
    Abstract: A degree of polymerization of cellulose ether is accurately controlled, and quality and a manufacturing process of the cellulose ether are stabilized. There is provided a method for producing depolymerized alkali cellulose having a degree of polymerization controlled, comprising at least a step of depolymerizing, in the presence of an oxygen-containing gas flow, alkali cellulose obtained by bringing a pulp into contact with an alkali solution, while measuring feeding and discharging amounts of oxygen in the oxygen-containing gas flow. There is also provided a method for producing cellulose ether, comprising at least a step of adding an etherifying agent to the depolymerized alkali cellulose having a degree of polymerization controlled.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: June 21, 2016
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Mitsuo Narita
  • Patent number: 9371349
    Abstract: Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1?, and 6? positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1?,6?-trichloro-4,1?,6?-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: June 21, 2016
    Assignee: Lexington Pharmaceuticals Laboratories, LLC
    Inventors: William Randal Erickson, Stephen Craig Fields
  • Patent number: 9364552
    Abstract: The present invention relates to a composition for inhibiting after-cataract including a hydrophilic sulfasalazine; a high content of hyaluronic acid; and a carrier containing an aqueous solution, and a method of preparing a composition for inhibiting after-cataract including the steps of adding hyaluronic acid powder to a hydrophilized sulfasalazine; and mixing the same with a specific condition.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: June 14, 2016
    Assignees: BMI KOREA CO., LTD, CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Yeong-Jun Baik, Choun-Ki Joo, Sung-Hee Lee, Jun-Sub Choi, Koo Woo
  • Patent number: 9321784
    Abstract: A process is described for making isohexides, comprising dehydrating one or more hexitols with an acid catalyst to form a crude dehydration product mixture including one or more isohexides, further processing the mixture to separate out one or more fractions of a greater purity or higher concentration of at least one of the isohexides, and hydrogenating at least one of a) the crude dehydration product mixture, b) a neutralized crude dehydration product mixture, following a neutralization of the crude dehydration product mixture, c) the product mixture following a neutralization step and further following a step to remove ionic species therefrom, d) a greater purity or higher concentration fraction, and e) a lesser purity or concentration fraction, by reaction with a hydrogen source in the presence of a hydrogenation catalyst. Hydrogenation improves the color and/or color stability of the material, especially of a finished isohexide product.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: April 26, 2016
    Assignee: Archer Daniels Midland Co.
    Inventors: Erik Hagberg, Erin M. Rockafellow, Brennan Smith, Kenneth F. Stensrud
  • Patent number: 9321703
    Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 26, 2016
    Assignee: Siluria Technologies, Inc.
    Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
  • Patent number: 9321702
    Abstract: Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 26, 2016
    Assignee: Siluria Technologies, Inc.
    Inventors: Greg Nyce, Peter Czerpak, Carlos Faz, Jarod McCormick, William Michalak, Bipinkumar Patel, Guido Radaelli, Tim A. Rappold, Ron Runnebaum, Erik C. Scher, Aihua Zhang, Joel Cizeron
  • Patent number: 9259480
    Abstract: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: February 16, 2016
    Assignee: Fina BioSolutions LLC
    Inventor: Andrew Lees
  • Patent number: 9254337
    Abstract: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: February 9, 2016
    Assignee: Fina BioSolutions, LLC
    Inventor: Andrew Lees
  • Patent number: 9238013
    Abstract: Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: January 19, 2016
    Assignee: Allergan Industrie, SAS
    Inventor: Pierre Lebreton
  • Patent number: 9212372
    Abstract: A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: December 15, 2015
    Assignees: Medicago Inc., Centre National de la Recherche Scientifique, Université De Rouen
    Inventors: Thomas Paccalet, Muriel Bardor, Christophe Rihouey, Véronique Gomord, Loïc Faye, Patrice Lerouge, Stéphanie Aquin, Louis-Philippe Vezina, Marc-André D'Aoust
  • Patent number: 9181293
    Abstract: A method of synthesising Aspalathin and its analogues or derivatives is disclosed. The method comprises synthesising a compound of formula 1 or its analogues or derivatives: wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of —H, —OH, hydrocarbyl groups, saccharide moieties and —OR15; R15 is selected from the group consisting of hydrogen, a hydrocarbyl group (e.g. methoxy or ethoxy), an acyl group and a benzyl group; and R11, R12, R13 and R14 are independently selected from the group consisting of —H, hydrocarbyl groups, saccharide moieties, an acyl group and a benzyl group.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: November 10, 2015
    Assignee: South African Medical Research Council
    Inventors: Jan Hendrik Van der Westhuizen, Daneel Ferreira, Elizabeth Joubert, Sussana Lucia Bonnet
  • Patent number: 9175323
    Abstract: This invention is directed to a process for treating biomass. The biomass is treated with a biomass swelling agent within the vessel to swell or rupture at least a portion of the biomass. A portion of the swelling agent is removed from a first end of the vessel following the treatment. Then steam is introduced into a second end of the vessel different from the first end to further remove swelling agent from the vessel in such a manner that the swelling agent exits the vessel at a relatively low water content.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: November 3, 2015
    Assignee: THE MICHIGAN BIOTECHNOLOGY INSTITUTE
    Inventors: Timothy J. Campbell, Farzaneh Teymouri
  • Patent number: 9162998
    Abstract: A process for preparing 5-hydroxymethylfurfural (HMF), which comprises a) feeding solutions (hereinafter called starting solution) comprising one or more saccharides and an organic solvent having a boiling point greater than 200° C. (at standard pressure) (called high boiler for short) and water, ?and a solvent having a boiling point greater than 60° C. and less than 200° C. (at standard pressure, called low boiler for short) to a reaction vessel, b) effecting a conversion of hexose to HMF in the reaction vessel in the presence of water vapor with simultaneous distillative removal of the HMF and c) obtaining, as the distillate, an aqueous, HMF-comprising solution (hereinafter called distillate).
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: October 20, 2015
    Assignee: BASF SE
    Inventors: René Backes, Benoit Blank, Alois Kindler, Carmen Feldner
  • Patent number: 9145350
    Abstract: There are provided methods for the valorization of carbohydrates. The methods comprise reacting a fluid comprising at least one carbohydrate with at least one metal catalyst or at least one metal catalytic system in a fluidized bed reactor so as to obtain at least one organic acid or a derivative thereof.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: September 29, 2015
    Assignee: POLYVALOR, LIMITED PARTNERSHIP
    Inventors: Gregory Patience, Ali Shekari, Youssef Farrie
  • Patent number: 9120876
    Abstract: A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Sugammadex is disclosed in the invention. The process involves reacting Gamma cyclodextrin with phosphorous halide in the presence of organic solvent.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: September 1, 2015
    Inventors: Ramamohan Rao Davuluri, Ravi Ponnaiah, Ravi Kanth Sribhashyam, Nandkumar Mecherili Valsan, Naresh Dongari, Prasad Chlnv, Guruswamy Batthini