Purification Or Recovery Patents (Class 536/127)
  • Patent number: 10329523
    Abstract: The subject matter herein provides a biotic method for recovering one or more hydrocarbons from a feedstock that includes one or more of oil shale, bituminous tar sand, coal and cellulous at atmospheric temperature and pressure. The method comprises loading the feedstock into a container, treating the feedstock in the container with a biomedium of micro-organisms, and forming an essentially liquid mixture from the feedstock and the biomass by rotary tumbling the feedstock and the biomedium in the container. The essentially liquid mixture is then separated into the one or more hydrocarbons by centrifuging.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: June 25, 2019
    Inventor: Raymond Roger Wallage
  • Patent number: 10227367
    Abstract: There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1? and 6? positions thereof; (v) quenching said mixture to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises perfluorooctane.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: March 12, 2019
    Assignee: Tate & Lyle Technology Limited
    Inventors: Thomas Eilers, Halil Aktas
  • Patent number: 10113155
    Abstract: The present invention provides steviol glycosyltransferase and a method for producing a steviol glycoside using this enzyme. The present invention provides a transformant transformed with a gene for steviol glycosyltransferase and a method for preparing such a transformant.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: October 30, 2018
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Eiichiro Ono
  • Patent number: 10113154
    Abstract: The invention provides a method for producing steviol glycosides. The invention provides a transformant having introduced therein the steviol glucosyltransferase and a method for producing steviol glycosides using the transformant.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 30, 2018
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Eiichiro Ono
  • Patent number: 10080372
    Abstract: The invention relates to a process for separating milk components, wherein proteins, sugars and minerals are separated into different fractions. The lactose of milk is first hydrolyzed completely or partially, after which proteins, minerals and sugars are separated into fractions in a phased nanofiltration. The obtained fractions may also be further processed by chromatography, membrane techniques, and/or evaporation to further improve the separation of said components. The invention also relates to a low-lactose or lactose-free milk composed of these fractions. By means of the invention, calcium and protein losses can be minimized. Also, the energy content of the product can be reduced.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: September 25, 2018
    Assignee: VALIO LTD.
    Inventors: Harri Kallioinen, Reetta Tikanmäki
  • Patent number: 10047168
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill. Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10047170
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10047169
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160°C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10035863
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a to pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 31, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 9919289
    Abstract: The present invention relates to a zeolite-based adsorbent comprising at least one zeolite of FAU structure of LSX type and comprising barium and/or potassium, in which the outer surface area of said zeolite-based adsorbent, measured by nitrogen adsorption, is between 20 m2·g?1 and 100 m2·g?1, limits inclusive. The present invention also relates to the use of such a zeolite-based adsorbent as an adsorption agent, and also to the process for separating para-xylene from aromatic isomer fractions containing 8 carbon atoms.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: March 20, 2018
    Assignees: IFP Energies Nouvelles, Arkema France
    Inventors: Ludivine Bouvier, Cécile Lutz, Catherine Laroche, Julien Grandjean, Arnaud Baudot
  • Patent number: 9663589
    Abstract: Disclosed herein are processes for providing a biopolymer from a biomass or source of chitin using ionic liquids. The processes involve contacting a biomass or source of chitin with an ionic liquid to produce a biopolymer comprising solution and precipitating the biopolymer from the solution with supercritical CO2, gaseous CO2, or combinations thereof.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: May 30, 2017
    Assignees: The Board of Trustees of The University of Alabama, The Intellectual Property Office of Institute of Process Engineering, Chinese Academy of Sciences
    Inventors: Robin D. Rogers, Patrick S. Barber, Chris S. Griggs, Gabriela Gurau, Xingmei Lu, Suojiang Zhang
  • Patent number: 9562064
    Abstract: Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage of the Stevia rebaudiana Bertoni plant, purification of steviol glycoside mixtures, Rebaudioside D and Rebaudioside A from a commercial Stevia extract, and purification of Rebaudioside D from remaining solutions obtained after isolation and purification of Rebaudioside A and a high purity mixture of steviol glycosides. The methods are useful for producing high purity Rebaudioside D, Rebaudioside A, and steviol glycoside mixtures. The high purity steviol glycosides are useful as non-caloric sweeteners in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 7, 2017
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9492547
    Abstract: The present invention relates to a new polymorphic form of inulin, designated delta inulin (dIN), to methods for the preparation of dIN, compositions comprising dIN and uses thereof. The present invention also relates to the use of dIN and compositions comprising dIN in the preparation of gamma inulin (gIN), compositions comprising gIN and uses thereof.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: November 15, 2016
    Assignee: VAXINE PTY LTD
    Inventors: Peter D. Cooper, Nikolai Petrovsky
  • Patent number: 9234051
    Abstract: Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: January 12, 2016
    Assignees: BAXALTA INCORPORATED, BAXALTA GMBH
    Inventors: Patrick N. Shaklee, Jennifer Bahr-Davidson, Srinivasa Prasad, Kirk W. Johnson
  • Patent number: 9102764
    Abstract: Disclosed are methods relating to monitoring the processing of polysaccharides and, in particular, monitoring the processing of guar in order to improve guar yield and/or lower impurity concentration in the wash effluent fluid.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: August 11, 2015
    Assignee: RHODIA OPERATIONS
    Inventors: Marie-Pierre Labeau, Kraig Luczak, Vincent Monin, Serge Henrot, Aziz Boukhelifa, Simon Firkins
  • Patent number: 9073959
    Abstract: A process for the production of sucrose-6-ester is disclosed. The process includes, in order, the steps of: (a) providing a first reaction mixture including sucrose, a reaction vehicle, and an organotin-based acylation promoter; (b) removing water from the first reaction mixture to afford a second reaction mixture that is substantially free from water; and (c) adding a carboxylic acid anhydride to the second reaction mixture to afford a third reaction mixture, thereby producing a sucrose-6-ester; wherein: during step (b), the removing of water includes distillation of water with the reaction vehicle using an apparatus supplying a heat flux of from 500 to 25,000 BTU/hrft2 (1577 to 78865 W/m2) selected from the group consisting of wiped film evaporators, agitated thin film evaporators, falling film evaporators and rising film evaporators.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: July 7, 2015
    Assignee: TATE & LYLE TECHNOLOGY LIMITED
    Inventors: Edward Micinski, David Coleman
  • Patent number: 9045515
    Abstract: The present invention relates to an improved process for the purification of tiacumicin B. Specifically, the invention relates to a simplified, optimised process for the purification of tiacumicin B from a fermentation broth, using chromatography techniques. In particular, the invention relates to a method for purifying tiacumicin B which comprises subjecting a liquid containing tiacumicin B to at least one hydrophobic interaction chromatography step. The process according to the invention is simpler than the processes according to the prior art, and can easily be used on a large scale for commercial production.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: June 2, 2015
    Assignee: OLON S.P.A.
    Inventors: Piera Fonte, Giovanni Lazzari
  • Patent number: 9012625
    Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: April 21, 2015
    Assignee: Glycom A/S
    Inventors: Gyula Dékany, Károly Ágoston, Istvan Bajza, Julien Boutet, Marie Bøjstrup, Mette Fanefjord, Ignacio Pérez Figueroa, Markus Hederos, Ferenc Horvath, Piroska Kovács-Pénzes, Lars Kröger, Johan Olsson, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas
  • Publication number: 20150093820
    Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 2, 2015
    Applicant: General Electric Company
    Inventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
  • Patent number: 8993749
    Abstract: A process for producing an eriocitrin-containing material comprises the steps of: preparing an eriocitrin-containing citrus extract from a citrus fruit using an extractant; and separating eriocitrin from the citrus extract. The step of separating eriocitrin from the citrus extract comprises the steps of: bringing the citrus extract into contact with a porous synthetic adsorption resin such that eriocitrin in the citrus extract is adsorbed on the porous synthetic adsorption resin, the porous synthetic adsorption resin comprising a phenol-formaldehyde resin as a main framework and having amino and phenolic hydroxyl groups; and eluting the eriocitrin adsorbed on the porous synthetic adsorption resin using an elution solvent.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: March 31, 2015
    Assignee: Pokka Corporation
    Inventors: Masanori Hiramitsu, Toshikazu Omori, Kenji Yamaguchi, Hiroaki Bessho
  • Publication number: 20150065698
    Abstract: There is described a method of isolating one or more of pectin, d-limonene, a flavour compound, a flavonoid, a soluble monosaccharide, a decomposition product of a monosaccharide and cellulose, from citrus material wherein said method comprises the microwave assisted hydrothermal low temperature treatment of citrus material.
    Type: Application
    Filed: April 4, 2013
    Publication date: March 5, 2015
    Inventors: James Hanley Clark, Lucie Anne Pfaltzgraff, Vitaliy Lvovich Budarin, Mario De Bruyn
  • Patent number: 8921541
    Abstract: The invention relates to an improved nanofiltration process for separating and recovering components, such as sugars and sugar alcohols from multicomponent mixtures. The process of the invention is characterized by collecting the nanofiltration retentate/permeate in several fractions with different purity, optional recycling of at least one of the collected nanofiltration retentate/permeate fractions to the nanofiltration and recovering the desired component from the nanofiltration permeate/retentate fractions by different methods. In one embodiment of the invention, the process comprises a combination of nanofiltration and chromatography.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: December 30, 2014
    Assignee: DuPont Nutritional Biosciences APS
    Inventors: Heikki Heikkila, Hannu Koivikko, Jari Lewandowski, Mika Manttari, Jari Mattila
  • Patent number: 8901291
    Abstract: The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: December 2, 2014
    Assignee: Glycom A/S
    Inventors: Julien Boutet, Gyula Dekany, Ágnes Jànosi, Gergely Pipa, Ferenc Horvàth, Krisztián Kovàcs, Ignacio Pérez Figueroa, Markus Hederos, Andreas Schroven, Ioannis Vrasidas, Piroska Kovács-Pénzes, Christian Risinger, Sándor Demkò, Lars Kröger, Christoph Röhrig
  • Publication number: 20140350222
    Abstract: Disclosed herein is a process for extracting lipid containing products from microalgal biomass, the process comprising: (i) treating an aqueous mixture comprising microalgal biomass with microwave radiation and (ii) recovering lipid containing products from the treated microalgal biomass.
    Type: Application
    Filed: October 19, 2012
    Publication date: November 27, 2014
    Inventors: Wei Zhang, Peng Su
  • Publication number: 20140336338
    Abstract: A process of treating polymeric nanofiltration membranes before separation of low molecular weight compounds from a solution comprising the same by nanofiltration, wherein the treatment of the nanofiltration membranes is performed with an treatment liquid under conditions which enhance the flux of the low molecular weight compounds to the nanofiltration permeate.
    Type: Application
    Filed: December 5, 2012
    Publication date: November 13, 2014
    Inventors: Jari Mattila, Hannu Koivikko
  • Patent number: 8877920
    Abstract: Described is a method for preparing a purified liquid containing carbohydrates. The method comprises the steps of: hydrolysing starch to a dextrose equivalent (DE) of 10 or above, thus obtaining a liquid of carbohydrates; removing a heavy weight sludge fraction from the light weight liquid of carbohydrates using centrifugation; filtering the remaining liquid of carbohydrates, the filter being capable of retaining coarser particles while allowing particles with a diameter less than 2 ?m to pass; performing membrane separation on the filtered liquid of carbohydrates using a membrane having a pore size at 2 ?m or below; and recovering a permeate stream of purified liquid containing carbohydrates. Also disclosed in a plant for performing the method.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: November 4, 2014
    Assignee: Alfa Laval Corporate AB
    Inventors: Frank Lipnizki, Wim Van Der Ham, Reiné Van Eldik
  • Patent number: 8871924
    Abstract: This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: October 28, 2014
    Assignee: Eastman Chemical Company
    Inventors: Charles Michael Buchanan, Norma Lindsey Buchanan, Elizabeth Guzman-Morales
  • Publication number: 20140316108
    Abstract: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.
    Type: Application
    Filed: November 1, 2012
    Publication date: October 23, 2014
    Inventors: Mary J. Wirth, Yirmin Hua, Zhaorui Zhang
  • Patent number: 8865923
    Abstract: A method for separating neutral and polar lipids from an oil of biological material, wherein the oil is fractionated using a mixture of a polar solvent comprising at least one carbon atom, water and an additional substance selected from the group consisting of: mono-, di- and oligosaccharides comprising from 3 to 10 monosaccharide units, said additional substance is present in an amount of at least 0.1 wt % calculated on the total weight of solvent, water and additional substance, to form at least two liquid fractions having different densities, wherein one fraction is rich in polar lipids and another fraction is rich in neutral lipids. An oil rich in polar lipids obtained from the method is disclosed, said oil I contains at least 40, preferably at least 50 lipid % polar lipids as calculated on the total amount of lipids in said oil and that the total amount of polar solvent and water in said oil is between 20 and 30 wt %. An oat oil containing high amounts of estolides of DGDG can further be obtained.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: October 21, 2014
    Assignee: Swedish Oat Fiber AB
    Inventor: Magnus Härröd
  • Publication number: 20140309416
    Abstract: In one aspect, provided herein are efficient methods for using ionic liquids. In some embodiments, only a small amount of ionic liquid is lost in a chemical process. For example, described herein is a method for separating one or more biomass components from an ionic liquid comprising contacting a composition comprising an ionic liquid and a biomass component with a fluid.
    Type: Application
    Filed: September 7, 2012
    Publication date: October 16, 2014
    Applicant: HYRAX ENERGY INC.
    Inventors: Rodrigo E. Teixeira, Kurtis G. Knapp, Travis A. Fixmer
  • Patent number: 8852606
    Abstract: Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilization of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide:MenC saccharide is >1.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: October 7, 2014
    Assignee: Novartis AG
    Inventor: Paolo Costantino
  • Publication number: 20140288299
    Abstract: The present invention relates to a process for preparing a short oligonucleotide comprising the steps of: (i) preparing a crude mixture comprising the oligonucleotide (ii) subjecting the mixture formed in step (i) to a desalting step; wherein the process does not comprise a chromatographic purification step.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 25, 2014
    Applicant: SANTARIS PHARMA A/S
    Inventors: Michael Meldgaard, Marianne Mogensen, Christian Frauendorf, Christoph Rosenbohm
  • Patent number: 8841441
    Abstract: The invention relates to a method for producing regenerated biopolymers in the form of carbohydrates, using a solvent system that contains the biopolymers dissolved therein. The solvent system is based on a melted ionic liquid and optionally a protic solvent or a mixture thereof. The biopolymers dissolved in the solvent system are precipitated in a coagulation medium, said medium comprising a protic coagulant or a mixture of protic coagulants. The method according to the invention is characterized in that the surface tension ? of the coagulant or the mixture of coagulants is 99% to 30% of the surface tension ? of water, the surface tension being measured according to ASTM D 1590-60 at a temperature of 50° C. The method according to the invention is economical and flexible and leads to advantageous products, especially in the form of staple fibers which are especially not fibrillated and have an advantageous wet to dry strength ratio.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: September 23, 2014
    Assignee: BASF SE
    Inventors: Eric Uerdingen, Michael Siemer, Michael Lutz, Thomas Wisniewski, Frank Hermanutz, Frank Gaehr
  • Publication number: 20140275519
    Abstract: A method for obtaining solutions of non-structurally modified salts of alginate, with endotoxin content less than 20 EU/g includes obtaining an alginate solution having a concentration ranging from 1.6 to 2.0% by weight by adding commercial grade alginate powder to a saline solution. The alginate solution obtained is filtered on at least one hydrophilic filter, and a filtered alginate solution is recovered. The filtered alginate solution obtained is further filtered on a charge-modified hydrophobic filter, and an alginate solution having an endotoxin content less than 20 EU/g is recovered.
    Type: Application
    Filed: May 30, 2014
    Publication date: September 18, 2014
    Applicant: GH Care, Inc. d/b/a Altucell, Inc.
    Inventors: Giuseppe Pietro Pio Basta, Riccardo Calafiore
  • Publication number: 20140256931
    Abstract: The present disclosure relates carbonaceous materials and to methods of using such carbonaceous materials for purifying oligomers produced from depolymerized biomass, such as lignocellulosic biomass.
    Type: Application
    Filed: October 18, 2012
    Publication date: September 11, 2014
    Applicants: BP CORPORATION NORTH AMERICA INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Po-Wen Chung, Alexandre Charmot, Alexander Katz, Amit A. Gokhal
  • Patent number: 8828732
    Abstract: The method of labeling a sugar chain from a biological sample employs a single reaction vessel for the sequential performance of the following steps of (a) isolating a sugar chain from a sample using a sugar-trapping substance; (b) washing the sugar-trapping substance having the sugar chains trapped thereon; (c) releasing the sugar chain from the sugar-trapping substance; and (d) labeling the released sugar chain with UV/visible or fluorescent compound having an amino group forming a stable labeled sugar in fewer steps than a conventional ion exchange based technique.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: September 9, 2014
    Assignee: Sumitomo Bakelite Co., Ltd.
    Inventors: Midori Abe, Hideyuki Shimaoka, Hiromitsu Kuramoto
  • Patent number: 8802843
    Abstract: Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: August 12, 2014
    Assignee: OROCHEM Technologies, Inc.
    Inventors: Anil R. Oroskar, Omkar M. Kulkarni, David W. House, Deepak Sharma, Rakesh Vikraman Nair Rema
  • Patent number: 8802842
    Abstract: The invention relates to a method for the preparation for a crystalline form of 1-chloro-4-(?-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: August 12, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Dirk Weber, Svenja Renner, Tobias Fiedler, Simone Orlich
  • Patent number: 8796434
    Abstract: ?-Lactosamine hydrochloride, substantially free of ?-lactosamine hydrochloride; a method of preparing ?-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallization of ?-lactosamine hydrochloride monohydrate; a method of preparing anhydrous ?-lactosamine hydrochloride; and use of ?-lactosamine hydrochloride as a food supplement or intermediate in synthesis.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: August 5, 2014
    Assignee: Glycom A/S
    Inventors: Gyula Dekany, Károly Ágoston, István Bajza, Marie Bøjstrup, Ignacio Fegueroa Pérez, Lars Kröger, Christoph H. Röhrig
  • Patent number: 8778689
    Abstract: We disclose the synthesis and use of chiral ionic liquids based on a substituted pentose, furanose, hexose, or pyranose sugar. The compounds and processes to make or use them are provided.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: July 15, 2014
    Assignee: The University of the West Indies
    Inventors: Gurdial Singh, Patrice G. J. Plaza, Bhoomendra A. Bhongade
  • Patent number: 8765937
    Abstract: A process for the ultrapurification of alginates is provided. In particular, the process may be used for microencapsulation in human cell transplants.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: July 1, 2014
    Assignee: GH Care, Inc.
    Inventors: Giuseppe Pietro Pio Basta, Riccardo Calafiore
  • Patent number: 8748595
    Abstract: Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: June 10, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Patrick N. Shaklee, Jennifer Bahr-Davidson, Srinivasa Prasad, Kirk Johnson
  • Patent number: 8742095
    Abstract: The present invention relates to a method of manufacturing a cereal bran product containing beta-glucan. According to the method, a plastic mass is formed from cereal bran by means of a thermo-mechanical treatment, and the mass is brought into contact with an enzyme that breaks up beta-glucan, with or without an enzyme that breaks up starch. After inactivating the enzyme, the bran is dried and, when so needed, ground. The cereal bran product manufactured according to the method has an essentially inextensible structure in a water environment. The product is suitable to be added to aqueous foodstuffs or to foodstuffs, the manufacture of which employs water.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: June 3, 2014
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Ilkka Lehtomäki, Olavi Myllymäki
  • Publication number: 20140147904
    Abstract: The present invention relates to a filtering apparatus and method for mixing a compound of solid and fluid phases, separating the phases and/or extracting fluid from the compound. One embodiment of the invention discloses a filtering apparatus comprising a first filter section accommodating a first group of filter members, and a second filter section accommodating a second group of filter members, a piping system providing pipelined fluid communication between the filter sections and between a filter section and said filter section's corresponding group of filter members, the piping system configured such that the filter members form filtered fluid openings of the filtering apparatus, and circulation means, such as a pump, configured for passing fluid in a forward flow and/or in a reverse flow between the filter sections. In particular the invention may be used for the mashing process in a beer brewing procedure.
    Type: Application
    Filed: August 13, 2012
    Publication date: May 29, 2014
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Peter Stubbe, Preben Bøje Hansen
  • Patent number: 8691559
    Abstract: A micro channel for recovering nucleic acid from a biological sample treated with a chaotropic ion, include an integrated portion composed of silica micro beads having a pore size of from 6 to 29 nm is formed in the channel.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: April 8, 2014
    Assignee: Sony Corporation
    Inventors: Michihiro Ohnishi, Yuta Kan, Tomoteru Abe
  • Patent number: 8674087
    Abstract: The present disclosure relates to processes useful in the isolation and purification of enfumafungin, which is classified as a triterpene glycoside antifungal compound and acts as a glucan synthase inhibitor. Enfumafungin has application in the treatment of conditions caused by fungal infection and is also useful as an intermediate in the preparation of other compounds useful as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthesis.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: March 18, 2014
    Assignee: Scynexis, Inc.
    Inventors: Jennifer M. Pollard, Rebecca A. Chmielowski, Lisa M. Dietrich, Francis P. Gailliot, Kent Goklen
  • Patent number: 8663654
    Abstract: The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. The invention also relates to the use of the PS/A as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative staphylococci and organisms carrying the ica (intracellular adhesin) locus, and to the use of antibodies directed to PS/A for inducing passive immunity to the same class of infections.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: March 4, 2014
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Julia Wang, David McKenney
  • Patent number: 8629267
    Abstract: A method for producing starch hydrolysate that includes processing in a high shear device a hydrolytic solution having a component selected from the group consisting of acids, hydrolytic enzymes, and combinations thereof, and an aqueous starch solution to produce a dispersion, wherein the high shear device is configured with a rotor and a stator; and transferring the dispersion from the high shear device to a reactor from which a starch hydrolysate product comprising dextrose is removed, wherein the operating temperature within the reactor is maintained at a temperature of less than about 160° C.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: January 14, 2014
    Assignee: H R D Corporation
    Inventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford G. Anthony, Gregory Borsinger, Aziz Hassan
  • Patent number: 8613858
    Abstract: The invention relates to a nanofiltration process for enriching and concentrating a neutral organic compound into the permeated liquid with negative retention.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: December 24, 2013
    Assignee: Dupont Nutrition Biosciences APS
    Inventors: Mika Mänttäri, Elina Sjöman, Heikki Heikkilä, Hannu Koivikko, Jutta Lindell
  • Publication number: 20130338086
    Abstract: Disclosed herein are methods for separating ionic impurities from monosaccharide processing streams using simulated moving bed chromatography.
    Type: Application
    Filed: January 7, 2013
    Publication date: December 19, 2013
    Applicant: Aptalis Pharma Canada Inc.
    Inventor: Aptalis Pharma Canada Inc.