Purification Or Recovery Patents (Class 536/127)
  • Publication number: 20130338086
    Abstract: Disclosed herein are methods for separating ionic impurities from monosaccharide processing streams using simulated moving bed chromatography.
    Type: Application
    Filed: January 7, 2013
    Publication date: December 19, 2013
    Applicant: Aptalis Pharma Canada Inc.
    Inventor: Aptalis Pharma Canada Inc.
  • Patent number: 8598337
    Abstract: This invention relates to improved methods for purifying polysaccharides from cellular components, such as a cell wall. The method relates to hydrolyzing and separating the polysaccharides, thereby resulting in purified polysaccharides useful for producing antigens, antibodies, and vaccines comprising the polysaccharides alone or conjugated to carrier molecules. This method is simple, rapid, efficient, scalable, and reproducible.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: December 3, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Francis Michon, Catherine Uitz
  • Patent number: 8598338
    Abstract: The present disclosure provides methods for isolating substantially pure and undegraded DNA from biological material via a solid support. The methods may use a DNA lysing solution that comprises a surfactant, a DNA-complexing salt (e.g., a lithium salt), and a buffer. Alternatively, the methods may use a solid support pre-treated with the DNA lysing solution.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: December 3, 2013
    Assignee: QIAGEN North American Holdings, Inc.
    Inventors: Robert Jackson Bair, Kristen Campbell Benedict, Wendy J. Kivens, Robert W. Kwiatkowski, Jr., Kim Paulsen, Daniel A. Strom, John M. Wages
  • Patent number: 8546561
    Abstract: Methods of making glucose and/or furfural from biomass require one or more supercritical fluids that may be used to process biomass, cellulose from the biomass, and/or xylose from the biomass. Examples of supercritical fluids for use in processing biomass include ethanol, water, and carbon dioxide at a temperature and pressure above the critical points for ethanol and carbon dioxide but at a temperature and/or pressure below that of the critical point for water. A supercritical fluid containing carbon dioxide and water may be used to convert cellulose to glucose or convert xylose to furfural. The fluid has a temperature and pressure above the critical point of carbon dioxide, but at least one of the temperature and pressure is below the critical point for water.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: October 1, 2013
    Assignee: Renmatix, Inc.
    Inventor: Srinivas Kilambi
  • Patent number: 8546560
    Abstract: The invention relates to a process for hydrolyzing cellulose, comprising: (a) contacting cellulose with a fluid mixture comprising supercritical CO2 and sub-critical or near-critical water to form a reactant mixture at a first temperature and first pressure for a first time period, wherein a reaction occurs and forms one or more hydrolysis products; (b) quenching the reaction; and (c) recovering at least one hydrolysis product.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: October 1, 2013
    Assignee: Renmatix, Inc.
    Inventor: Srinivas Kilambi
  • Patent number: 8536326
    Abstract: A method for preparing sucralose with high yield, comprising the following preparation steps: First, negative effects of other impurities on reaction are reduced by first preparing a pure Vilsmeier chlorinating reagent. Second, side reactions are prevented by adding composite catalyst to increase selectivity of chlorination reaction. Third, by extracting less polar impurities using less polar solvent when sucralose-6-ester is undergoing deesterification, products are qualified at the very first time so that refining steps are avoided. Accordingly, product loss is reduced and product yield is increased. By using the present invention to prepare sucralose, product yield could be increased to more than 40%.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: September 17, 2013
    Assignee: Hubei Yitai Pharmaceutical Co., Ltd.
    Inventors: Hengbo Liang, Zhengyou Wang, Li Rao
  • Patent number: 8530644
    Abstract: The present invention relates to a method for removing impurities from biopolymer material, e.g. polysaccharides, polypeptides or polynucleotides. More particularly, the present invention provides a method of reducing lipopolysaccharide levels in a lipopolysaccharide containing biopolymer material, comprising the successive steps of: a) providing an aqueous solution containing 0.05-50 wt. % of dissolved lipopolysaccharide-containing biopolymer material; 0.001-10 wt.% of a surfactant; 0.05-15 wt. % of solid adsorbent; and at least 50 wt. % of water; b) allowing the adsorbent to adsorb lipopolysaccharides; c) separating the solid adsorbent containing adsorbed lipopolysaccharides from the remaining aqueous solution; and d) recovering the biopolymer material containing a reduced level of lipopolysaccharide from the separated aqueous solution.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: September 10, 2013
    Assignee: Bender Analytical Holding B.V.
    Inventors: Johannes Caspar Mathias Elizabeth Bender, Pieter Sebastiaan Vermeulen
  • Patent number: 8524889
    Abstract: An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-?-maltosyl- and/or 6-?-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: September 3, 2013
    Assignee: Hayashibara Co., Ltd.
    Inventors: Tomoyuki Nishimoto, Katsuhiko Hino, Takanori Okura, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 8524888
    Abstract: The present invention relates to a method of producing D-psicose crystals from a D-psicose solution by using supersaturation.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: September 3, 2013
    Assignee: CJ Cheiljedang Corp.
    Inventors: Kang Pyo Lee, Sang Hoon Song, Seung Won Park, Sung Bo Kim, Young Ho Hong, Joo Hang Lee, Taek Beom Kim, Jun Gap An, Jung Hoon Kim
  • Patent number: 8524887
    Abstract: This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: September 3, 2013
    Assignee: Eastman Chemical Company
    Inventors: Charles Michael Buchanan, Norma Lindsey Buchanan, Elizabeth Guzman-Morales
  • Patent number: 8518185
    Abstract: Method of producing granulated maltitol, including the stages: preparing maltitol syrup having less than 50 wt.% dry matter and greater than 70 wt.% maltitol, introducing to a fluidized air bed granulator, a pulverulent bed of crystallized maltitol with a concentration at least equal to 99 wt.% and a mean diameter between 30 and 100 ?m, controlling the air inlet temperature between 100 and 120° C. and air velocity between 1 and 2 m/s, fine spraying the maltitol syrup into the granulator, at between 35 and 45° C., onto the moving pulverulent bed; the bed being between 30 and 60° C.; the mass of the bed representing constantly at least 2.5 times the mass of the sprayed syrup, drying, after fine spraying, by raising the air temperature below the melting point of maltitol to obtain a bed temperature between 70 and 80° C., cooling the granulated maltitol to at most 25° C. and collecting.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: August 27, 2013
    Assignee: Roquette Freres
    Inventors: Baptiste Boit, Pierrick Duflot, Jose Lis
  • Patent number: 8487090
    Abstract: A preparation of a kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution containing ginsenoside Rg3 0.5˜10 mg/ml: add 0.1-5% of ginsenoside solution to 0.1˜30% of adjuvant A, B{circle around (1)}{circle around (2)}{circle around (5)} at the temperature of 40˜100° C., the ratio of these two is 1:1˜300, add water after the solvent is recycled under reduced pressure; another kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution contains 0.1˜2 mg/ml of 20(R) of the ginsenoside Rg3, the preparation: add 0.1˜5% of ginsenoside solution to 20˜65% of adjuvant B{circle around (3)}{circle around (4)} at the temperature of 60˜100° C., main material to adjuvant B=1:100˜400, add water after the solvent is recycled under reduced pressure.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: July 16, 2013
    Assignee: Dalian Fusheng Natural Medicine Development Co., Ltd.
    Inventors: Li Fu, Qi Lu
  • Patent number: 8476388
    Abstract: Polymers useful as catalysts in non-enzymatic saccharification processes are provided. Provided are also methods for hydrolyzing cellulosic materials into monosaccharides and/or oligosaccharides using these polymeric acid catalysts.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: July 2, 2013
    Assignee: Midori Renewables, Inc.
    Inventors: John M. Geremia, Brian M. Baynes, Ashish Dhawan
  • Patent number: 8476424
    Abstract: A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary amide solvent, and the contacting step forms a de-acidified phase containing the tertiary amide solvent and a phase containing the extraction medium and the carboxylic acid. Both the liquid that contains the tertiary amide solvent and the de-acidified phase may also contain a sucrose-6-acylate.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: July 2, 2013
    Assignee: Tate & Lyle Technology Limited
    Inventors: John Kerr, Robert Jansen, Christian J. Isaac, James Edwin Wiley, Jr., Duane A. Leinhos
  • Publication number: 20130165632
    Abstract: Provided is a novel method for separating water-soluble biological substances. A separating agent is composed by bonding a polysaccharide such as cellulose or amylose to the surface of a carrier by chemical bonding, and water-soluble biological substances are separated from a mixture of two or more types of water-soluble biological substances by chromatography using the separating agent.
    Type: Application
    Filed: September 9, 2011
    Publication date: June 27, 2013
    Inventors: Atsushi Ohnishi, Ryota Hamasaki
  • Patent number: 8471002
    Abstract: Processes for producing dairy products having lower levels of neutral lipids, and/or higher levels of polar lipids, by extraction using near critical carbon dioxide or dimethyl ether. These products may be used as ingredients in infant formulas. Infant formulas containing beta-serum are also claimed. “Beta-serum” means an aqueous dairy ingredient separated from dairy streams containing greater than 60% fat which have been through phase inversion from an oil-in-water to a water-in-oil emulsion, such as the serum produced during the production of butter oil.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: June 25, 2013
    Assignee: Fonterra Co-Operative Group Limited
    Inventors: Katrina Fletcher, Owen Catchpole, John Bertram Grey, Mark Pritchard
  • Publication number: 20130116414
    Abstract: A method is provided for extraction of chemical compounds from an organism having a cell wall that includes adding nanomaterials, which may be metallic nanofibers such as silver nanofibers, to the organism.
    Type: Application
    Filed: October 19, 2012
    Publication date: May 9, 2013
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Board of Supervisors of Louisiana State Universit
  • Patent number: 8431551
    Abstract: Nutritional compositions, formulations, and intermediates are provided which may be utilized to formulate various sweeteners and other products. The formulations described herein are made from constituents found in soils or fossilized soils.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: April 30, 2013
    Inventors: Albert Duoibes, Carl Nannini
  • Patent number: 8420609
    Abstract: The present invention describes natamycin comprising needle shaped crystals.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: April 16, 2013
    Assignee: DSM IP Assets, B.V.
    Inventors: Ben Rudolf de Haan, Ferdinand Theodorus Jozef van Rijn
  • Patent number: 8410064
    Abstract: The present invention encompasses classical cannabinoid metabolites and uses thereof.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: April 2, 2013
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Anna Radominska-Pandya, Grover Miller, Jeffery Moran
  • Publication number: 20130079509
    Abstract: A process of treating polymeric nanofiltration membranes before separation of low molecular weight compounds from a solution comprising the same by nanofiltration, characterized in that the treatment of the nanofiltration membranes is performed with an organic liquid under conditions which enhance the flux of the low molecular weight compounds to the nanofiltration permeate.
    Type: Application
    Filed: June 7, 2011
    Publication date: March 28, 2013
    Inventors: Jari Mattila, Hannu Koivikko
  • Publication number: 20130072675
    Abstract: The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
    Type: Application
    Filed: May 19, 2011
    Publication date: March 21, 2013
    Applicant: GLYCOM A/S
    Inventors: Julien Boutet, Gyula Dekany, Ágnes Jánosi, Gergely Pipa, Ferenc Horváth, Krisztián Kovács, Ignacio Pérez Figueroa, Markus Hederos, Andreas Schroven, Ioannis Vrasidas, Piroska Kovács-Pénzes, Christian Risinger, Sándor Demkó, Lars Kröger, Christoph Röhrig
  • Patent number: 8399633
    Abstract: During the production of recombinant proteins from gram negative bacteria, lipopolysaccharides (LPS, endotoxin) are released along with the protein of interest. In many instances, LPS will copurify with the target protein due to specific or non-specific protein-ILPS interactions. We have investigated the ability of alkanediols to effect the separation of LPS from protein-LPS complexes while the complexes are immobilized on anion or cation exchange chromatographic media. Alkanediols provide a safer alternative to the use of other organics such as alcohols or acetonitrile due to their lower toxicity and decreased flammability. In addition, they are less costly than many of the detergents that have been used for such purposes. LPS removal efficiency increased with increasing alkane chain length. 1,2-alkanediols were more effective than terminal alkanediols in the separation of LPS from protein LPS complexes.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: March 19, 2013
    Assignee: Fujifilm Diosynth Biotechnologies U.S.A., Inc.
    Inventors: Philip Alfred Ropp, Michael Van Alen Murray
  • Patent number: 8394935
    Abstract: An object of the present invention is to provide a industrially appropriate method for producing the ?-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein ?-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl-1-O-alkyl-ribofuranose and 2,3-di-O-acyl-1-O-alkyl-5-deoxy-ribofuranose.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 12, 2013
    Assignee: API Corporation
    Inventors: Manabu Katsurada, Tomoko Sasaki, Yasuko Nakajima, Nobuo Kyoumura
  • Publication number: 20130048853
    Abstract: An adsorbent that enables solid phase extraction with high efficiency and good selectivity of solutes having a broad chromatographic polarity range including high-polarity solute molecules while suppressing adsorption of impurities, and a solid phase extraction method therefor are provided. A heterocyclic-ring-containing copolymer adsorbent that is provided herein comprises a copolymer that comprises: a multifunctional heterocyclic-ring-containing monomer having a heterocyclic ring containing at least two heteroatoms in the ring system; and a monomer that is copolymerizable with the multifunctional heterocyclic-ring-containing monomer, wherein the multifunctional heterocyclic ring constitutes the main chain structure.
    Type: Application
    Filed: April 28, 2011
    Publication date: February 28, 2013
    Inventors: Jun Nunoshige, Hiroyuki Kagawa, Shinya Ito, Katsuhiro Kanda, Izumi Waki, Kotaro Araya, Terumi Tamura
  • Publication number: 20130045946
    Abstract: The present invention describes sulodexide or at least one of its components for use in the reduction of circulating matrix metalloproteinase (MMPs), in particular MMP-9. Sulodexide and its composition are useful for the treatment of pathologies wherein the MMPs are involved, such as cardiovascular disease, cardiovascular disease caused by diabetes, varicose veins, chronic venous insufficiency (CVI), gastrointestinal ulcers, pulmonary disease, and neoplastic pathologies.
    Type: Application
    Filed: April 20, 2011
    Publication date: February 21, 2013
    Inventors: Giuseppe Claudio Viscomi, Ferdinando Mannello, Cristiana Bruno
  • Patent number: 8372609
    Abstract: Concentrated sugar solutions obtained from polysaccharide enriched biomass by contacting biomass with water and at least one nucleophilic base to produce a polysaccharide enriched biomass comprising a solid fraction and a liquid fraction and then contacting enriched biomass with a dilute mineral acid selected from the group consisting of sulfuric acid, phosphoric acid, hydrochloric acid, nitric acid, or a combination thereof, to produce an intermediate saccharification product, which is contacted with an enzyme consortium to produce a final saccharification product comprising fermentable sugars.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: February 12, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventor: Subramaniam Sabesan
  • Publication number: 20130035471
    Abstract: The present invention relates to a new streptavidin muteins. This mutein is The muteins are capable of oligomerization to form tetramers, with relatively strong subunit interactions, dissociation constant (KD) for biotin in this mutein in the range of 10?7 to 10?8M, off-rate (koff) for the bound biotin in the streptavidin-biotin complex in the range of 10?4 sec?1, stable enough to allow reuse, and producible producable with reasonable production yield via secretion in a soluble functional state without the requirement of refolding streptavidin via the tedious and expensive denaturation and renaturation processes.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 7, 2013
    Inventors: Sui-Lam Wong, Sau-Ching Wu, Isabelle Barrette-Ng, Ken Ng
  • Patent number: 8362182
    Abstract: Strongly acidic cation exchangers with high mechanical, osmotic and oxidation stability can be prepared by sulfonating bead polymers formed from one or more vinylaromatic monomer(s), one or more crosslinker(s) and from 0.2 to 20% by weight of one or more vinyl ethers and/or vinyl esters.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: January 29, 2013
    Assignee: LANXESS Deutschland GmbH
    Inventors: Pierre Vanhoorne, Hans-Jurgen Wedemeyer
  • Patent number: 8357796
    Abstract: A simple, inexpensive, and efficient method for separation and purification of the ?-and ?-forms of penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separation ?-PGG or ?-PGG from a mixture containing ?-PGG and ?-PGG and other chemicals. The method for separation of ?-PGG from a mixture of ?-PGG and ?-PGG comprises the steps of: adding water to a sample containing 50% or more ?-PGG and 50% or less ?-PGG; mixing the PGG and water to dissolve the PGG; filtering out any undissolved particles; and allowing the filtered solution to stand undisturbed until crystals form.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: January 22, 2013
    Assignee: Ohio University
    Inventors: Yulin Ren, Klaus B. Himmeldirk, Xiaozhou Chen
  • Publication number: 20130018183
    Abstract: A method and a device for making reducing sugar firstly combine a bio-substance containing lignocellulose with a solvent, thereby conducting a degradation reaction upon afore mixture through an autoclave so as to promote the bio-substance to solvent ratio during the production. Thus, a reducing sugar solution of a high concentration is produced. In the meantime, the bio-substance containing lignocellulose does not need a high-temperatured steaming after the degradation. Therefore, the water amount and the energy resources that are applied in the present invention are less than those of the conventional technique. Further, the autoclave is a common apparatus in the market, which facilitates in an easy purchase, decreases the producing cost, and benefits the product promotion.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 17, 2013
    Inventors: Alex Chen-Chang Chang, Chiu-Yue Lin, Ying-Hsuan Tu, Ming-Hsiang Huang
  • Publication number: 20120308632
    Abstract: A method comprises preventing or inhibiting bacterial adhesion and/or bacterial biofilm development by treating a substrate with a composition of a soluble group II capsular polysaccharide obtained from a bacterial strain.
    Type: Application
    Filed: May 29, 2012
    Publication date: December 6, 2012
    Inventors: Jean-Marc GHIGO, Jaione Valle, Sandra Da Re
  • Patent number: 8324377
    Abstract: A water-soluble cellulose ether is separated from its suspension by passing a suspension of water-soluble cellulose ether particles in water through a filter of perforated metallic or ceramic filter medium under pressure, removing the filter cake of water-soluble cellulose ether from the filter medium, and cleaning the filter medium with steam, compressed air or water under pressure. The invention enables to separate a water-soluble cellulose ether, especially having a high dissolution temperature, avoids the filter from being clogged, and extends the operative time of the filter.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: December 4, 2012
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Kazuhisa Hayakawa, Shinichi Kurotani, Mitsuo Narita
  • Patent number: 8324374
    Abstract: Disclosed is a novel process which has low facility load, requires a reduced amount of energy, is highly safe, and enables to produce a monosaccharide such as glucose and xylose by decomposing a cellulose-based substance under conditions where a substance used for decomposing the cellulose-based substance (e.g., a solvent, a catalyst) can be separated, collected and re-used readily. Also disclosed is a novel process for producing ethanol from the monosaccharide through ethanol fermentation. Specifically disclosed is a process for producing a monosaccharide, which comprises disaggregating/finely pulverizing a cellulose-based substance, mixing the resulting material with a phosphate solution to disperse the resulting material in the phosphate solution, and decomposing cellulose in the solution at a temperature of 100° C. or lower while irradiating with ultraviolet ray optionally in the presence of titanium dioxide.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: December 4, 2012
    Assignee: Taiyu Kensetsu Kabushiki Kaisha
    Inventor: Takashi Kawasaki
  • Publication number: 20120301948
    Abstract: The present invention provides for a method of hydrolyzing a cellulose, hemicellulose, or ligno-cellulose comprising: (a) contacting (i) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase comprising cellulose, hemicellulose, or ligno-cellulose, or a mixture thereof, and (ii) an acid, such that the cellulose, hemicellulose, or ligno-cellulose is hydrolyzed into sugar, and (b) optionally adding water to the IL or ILA phase wherein the proportion of water in the IL or ILA phase does not exceed about 60% by weight. The present invention also provides for a method of recovering a sugar comprising contacting an IL or ILA phase and an organic phase comprising an organic acid.
    Type: Application
    Filed: March 30, 2012
    Publication date: November 29, 2012
    Inventors: Timothy Charles R. Brennan, Bradley M. Holmes, Blake A. Simmons, Harvey W. Blanch
  • Patent number: 8309711
    Abstract: The method of forming a filter cake from a slurry comprising the steps of feeding the slurry into a filter housing, wherein the filter housing includes a plurality of vertical filter elements; pressing the slurry into the filter housing against the filter elements resulting in i) a filtrate passing through the filter elements and exiting out an exhaust port of the filter housing; ii) forming a solid cake on the filter elements; feeding a wash liquid into the filter housing while draining out the slurry by opening the slurry drain valve; closing the slurry drain valve and then continually feeding wash liquid through the cake and into the filter tube of the filter housing; stopping the feed of wash liquid; introducing a gas into the filter housing and draining out the wash liquid by opening a bottom drain valve; stopping the gas flow and opening a drain to exit most of the gas and remaining wash liquid; opening the bottom cake discharge valve; and back pulsing by a gas to break and to release the filter cake fr
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: November 13, 2012
    Assignee: Corn Products Development Inc.
    Inventor: Nathan Wiley
  • Publication number: 20120282655
    Abstract: Methods are disclosed for increasing the level of soluble C5 saccharides produced from lignocellulosic biomass comprising acidifying fractionated lignocellulosic biomass to prevent the recondensation of soluble C5 saccharides, including C5 oligosaccharides and xylose and arabinose monomers, to insoluble higher molecular weight C5 oligosaccharides.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Applicant: Renmatix, Inc.
    Inventor: Phillip R. Gibbs
  • Publication number: 20120282656
    Abstract: Methods are disclosed for increasing the level of C5 monosaccharides produced from lignocellulosic biomass using a multistage fractionation process to handle recalcitrant C5 oligosaccharides without producing unwanted degradation products. Methods for reducing C5 monosaccharides degradation products produced from lignocellulosic biomass are also disclosed. In addition, compositions and products produced by the methods are disclosed.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Applicant: Renmatix, Inc.
    Inventor: Phillip R. Gibbs
  • Patent number: 8299239
    Abstract: Disclosed is the preparation of 2-deoxy-D-erythro-2,2-difluoro-ribofuranose-3,5-dibenzoate, a known intermediate for the preparation of Gemcitabine, by means of a reduction process; further disclosed is the purification of Gemcitabine by chromatography and the purification of Gemcitabine hydrochloride by crystallization techniques from ternary solvent mixtures. The main advantage of the invention is providing Gemcitabine hydrochloride with purity in conformity with the Pharmacopoeia requirements, as well as a process particularly convenient from the industrial point of view.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: October 30, 2012
    Assignee: Prime European Therapeucials S.p.A.
    Inventors: Alberto Varalli, Paolo Anesa, Maria Argese, Giuseppe Guazzi
  • Patent number: 8298436
    Abstract: Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful as intermediates in the preparation of or as additives to AFFF (aqueous film forming foam) formulations used for the extinguishment of fuel and solvent fires.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: October 30, 2012
    Assignee: Ansul, Incorporated
    Inventor: Jeffrey D. Michael
  • Patent number: 8283463
    Abstract: A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 9, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20120226032
    Abstract: Described is a method for preparing a purified liquid containing carbohydrates. The method comprises the steps of: hydrolysing starch to a dextrose equivalent (DE) of 10 or above, thus obtaining a liquid of carbohydrates; removing a heavy weight sludge fraction from the light weight liquid of carbohydrates using centrifugation; filtering the remaining liquid of carbohydrates, the filter being capable of retaining coarser particles while allowing particles with a diameter less than 2 ?m to pass; performing membrane separation on the filtered liquid of carbohydrates using a membrane having a pore size at 2 ?m or below; and recovering a permeate stream of purified liquid containing carbohydrates. Also disclosed in a plant for performing the method.
    Type: Application
    Filed: June 25, 2010
    Publication date: September 6, 2012
    Inventors: Frank Lipnizki, Wim Van Der Ham, Reiné Van Eldik
  • Publication number: 20120220740
    Abstract: Polymers useful as catalysts in non-enzymatic saccharification processes are provided. Provided are also methods for hydrolyzing cellulosic materials into monosaccharides and/or oligosaccharides using these polymeric acid catalysts.
    Type: Application
    Filed: February 27, 2012
    Publication date: August 30, 2012
    Applicant: Midori Renewables, Inc.
    Inventors: John M. GEREMIA, Brian M. BAYNES
  • Patent number: 8252922
    Abstract: The present application discloses a method for crystallizing sucralose, which uses an alcohol solvent or a mixed solvent of alcohol and other solvent(s) in the crystallization of sucralose.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: August 28, 2012
    Assignee: JK Sucralose Inc.
    Inventors: Fei Wang, Haibing He, Jinshan Wu, Xin Yang, Yongzhu Yu, Zhisong Fan
  • Publication number: 20120214974
    Abstract: A spin column device, which contains a rigid porous filter that retains its shape during centrifugation, chromatography methods using the device to isolate a desired substance, e.g., a biological molecule, from other substances in a mixture, and kits containing the device with one or more reagents for use in the method.
    Type: Application
    Filed: May 2, 2012
    Publication date: August 23, 2012
    Applicant: BIOVENTURES, INC.
    Inventor: Elliott P. Dawson
  • Publication number: 20120190840
    Abstract: The invention provides a process for alcohol production from a cellulosic material wherein a said cellulosic material is subjected to acid hydrolysis to yield an aqueous hydrolysate, said hydrolysate is introduced into a separator at a hydrolysate inlet, an extraction solvent is introduced into said separator at at least two extraction solvent inlets, a residue containing oligosaccharides is removed from said separator at a residue discharge outlet, and acid-containing extraction solvent is removed from said separator at an extraction solvent discharge outlet, wherein removal of said extraction solvent from said separator through said discharge outlet occurs downstream of at least one said extraction solvent inlet and upstream of at least one other said extraction solvent inlet.
    Type: Application
    Filed: April 20, 2010
    Publication date: July 26, 2012
    Applicant: WEYLAND AS
    Inventor: Karl Ragnar Weydahl
  • Patent number: 8227232
    Abstract: Object: To provide a thermostable L-ribose isomerase. Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: July 24, 2012
    Assignees: National University Corporation Kagawa Univeristy, Rare Sugar Production Technical Research Laboratories, LLC., Matsutani Chemical Industry Co., Ltd.
    Inventors: Ken Izumori, Kenji Morimoto, Goro Takata, Masaaki Tokuda, Yoshio Tsujisaka, Kei Takeshita, Keiji Tsusaki, Kazuhiro Okuma
  • Publication number: 20120184721
    Abstract: The present invention provides an apparatus for separating components of a solid feedstock, in particular lignocellulosic solid biomass feedstock, and a method for using the same. The apparatus feeds the solid feedstock in one direction and provides a reaction fluid or an extraction fluid in an opposite direction of the solid feedstock to rapidly separate various components from the solid feedstock.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 19, 2012
    Inventors: Richard C. Wingerson, Chim Yong Chin
  • Patent number: 8212022
    Abstract: A process for the purification of aqueous feed streams containing sucralose and/or sucralose 6-esters includes, providing an aqueous feed stream including the sucralose and/or sucralose 6-esters, concentrating the aqueous feed stream to form a concentrated aqueous feed stream containing at least 10 wt % total carbohydrates and extracting the concentrated aqueous feed stream with an organic solvent and producing an organic extract and an aqueous extract, in which the organic solvent is immiscible with water, and in which the carbohydrate preferentially passes into the organic extract.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: July 3, 2012
    Assignee: Tate & Lyle Technology Limited
    Inventors: Edward Micinski, James Edwin Wiley, Jr.
  • Patent number: 8207298
    Abstract: The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: June 26, 2012
    Assignee: Archemix Corp.
    Inventors: Paul Hatala, William J. Issa