Purification Or Recovery Patents (Class 536/127)
  • Patent number: 8207284
    Abstract: Strongly acidic cation exchangers with high mechanical, osmotic and oxidation stability can be prepared by sulfonating bead polymers formed from one or more vinylaromatic monomer(s), one or more crosslinker(s) and from 0.2 to 20% by weight of one or more vinyl ethers and/or vinyl esters.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: June 26, 2012
    Assignee: LANXESS Deutschland GmbH
    Inventors: Pierre Vanhoorne, Hans-Jurgen Wedemeyer
  • Patent number: 8197699
    Abstract: The present invention describes a process for preparing methylhydroxyalkylcellulose having a small number of colored particles by separation of methylhydroxyalkylcellulose from aqueous suspension with subsequent washing of the methylhydroxyalkylcellulose using a specially equipped rotary pressure filter.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: June 12, 2012
    Assignee: Dow Global Technologies LLC
    Inventors: Martin Kowollik, Wolfgang Dannhorn, Erik-Andreas Klohr, Hartwig Schlesiger, Bernhard Kranz, Helmut Holste, Gerd Sonnenberg
  • Patent number: 8192775
    Abstract: The present invention relates to microcrystallized polyol comprising at least two polyols, wherein said polyols are selected from the group consisting of maltitol, xylitol and lactitol and wherein said composition contains at least 35% by weight of each of at least two of said polyols microcrystallized together into a solid microcrystalline product. The present invention also relates to a process for the microcrystallization of polyols into a polyol composition. The microcrystallized polyol composition can be used in confectionery, foodstuffs, oral hygiene products and pharmaceuticals and in dietetic products.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: June 5, 2012
    Assignee: Danisco Sweeteners Oy
    Inventors: Olli-Pekka Eroma, Johanna Nygren, Heikki Heikkila, Per Bo Sorensen, Marja-Leena Sarkki, Ian Fairs, Hakan Gros
  • Publication number: 20120130066
    Abstract: A solute is precipitated from a solution of a solute, a solvent and a non-solvent by preparing the solutions and introducing the solution into a precipitation chamber contain a supercritical fluid.
    Type: Application
    Filed: November 22, 2010
    Publication date: May 24, 2012
    Inventors: Yi Li, Footim Chau, Aizheng Chen, Junyan Hu, Tsuiyan Lau
  • Publication number: 20120115167
    Abstract: A method for isolating a target bioentity from a biological sample, comprises contacting the biological sample with a magnetically-labelled ligand having selective binding affinity for the target bioentity, or for a determinant on the target bioentity, to form a target bioentity/labelled ligand complex, locating a separation module having a defined fluid flow path in the magnetic field of a magnetic module, the magnetic module comprising an array of at least two magnets in which adjacent magnets in the array are aligned with opposing polarity; passing the biological sample through the separation module to subject the biological sample to the magnetic field while the sample is passing through the defined fluid flow path to magnetically capture the target bioentity/labelled ligand complex by arresting or hindering movement of the complex within the defined fluid flow path; removing the separation module from the magnetic field; and recovering the target bioentity/labelled ligand complex from the fluid flow path
    Type: Application
    Filed: April 22, 2010
    Publication date: May 10, 2012
    Inventors: Howard Milne Chandler, Michael Bruce Chandler
  • Patent number: 8173799
    Abstract: A composition of a loose mass of comminuted raw cotton linter fibers has a bulk density of at least 8 g/100 ml and at least 50% of the fibers in the mass passes through a US standard sieve size #10 (2 mm opening). This composition is made by obtaining a loose mass of first cut, second cut, third cut, or mill runs raw cotton linters or mixtures thereof and comminuting the loose mass of raw cotton linters to a size wherein at least 50% pass through a US standard sieve size #10 (2 mm opening). This composition is used to make cellulose ether derivatives.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: May 8, 2012
    Assignee: Hercules Incorporated
    Inventors: Paul C Gillette, Thomas G. Majewicz, Arjun C. Sau
  • Publication number: 20120077285
    Abstract: The present invention relates to a method for purifying biomolecules or for analyzing whether an aqueous phase contains biomolecules by means of magnetic separation. The invention further relates to uses, to devices, and to kits that relate to the method according to the invention.
    Type: Application
    Filed: March 25, 2010
    Publication date: March 29, 2012
    Inventor: Janina Cramer
  • Patent number: 8143392
    Abstract: A method of extracting starch from corn. The method comprises steeping ground corn in a mixture of ammonium hydroxide and water, for a period of between 45 minutes and 20 hours wherein the mixture has a pH level between about 11.3 and 11.4. This method provides the advantage of extracting starch from corn with higher yields in less time.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: March 27, 2012
    Inventor: Michael Madson
  • Publication number: 20120071414
    Abstract: The present invention relates to a method for extracting organic molecules and/or organic minerals from a limestone material, including placing said limestone material in contact with a solution including at least one organic solvent, water and at least one acid, as well as to the organic molecules and/or organic minerals produced by the method. The products produced by the method can be used, for example, in therapeutic and non-therapeutic fields, in particular the agri-food, cosmetic and medical fields.
    Type: Application
    Filed: April 9, 2010
    Publication date: March 22, 2012
    Applicants: Centre National De La Recherche Scientifique-CNRS-, Universite D'Orleans, Museum National D'Histoire Naturelle
    Inventors: Xavier Bourrat, Evelyne Lopez, Marthe Rousseau
  • Patent number: 8124758
    Abstract: A process is described for the preparation of N-Acetyl-D-mannosamine monohydrate of formula (I) a specific intermediate in the synthesis of N-Acetyl-neuraminic acid, that is an important starting product for the synthesis of various pharmaceutically active products.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 28, 2012
    Assignee: Inalco S.p.A.
    Inventors: Giovanni Cipolletti, Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci
  • Publication number: 20120046460
    Abstract: The invention relates to a method of purifying glucose polymers for the production of peritoneal dialysis solutions, characterized in that it includes at least one step of processing activated carbon and/or granular black, at least one sterilizing filtration step, at least one heat treatment step, and at least one ultrafiltration step.
    Type: Application
    Filed: April 29, 2010
    Publication date: February 23, 2012
    Applicant: ROQUETTE FRERES
    Inventors: Marc Biguet, Stéphane Bourdain, Pierrick Duflot
  • Publication number: 20120045802
    Abstract: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, sequentially adding solvent sets to the algal biomass, and sequentially separating solid biomass fractions from liquid fractions to arrive at a liquid fraction comprising neutral lipids. The method also includes esterifying the neutral lipids, separating a water miscible fraction comprising glycerin from a water immiscible fraction comprising fuel esters, carotenoids, and omega-3 fatty acids. The method also includes obtaining a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising carotenoids and omega-3 fatty acids. The method includes hydrogenating and deoxygenating at least one of (i) the C16 or shorter fuel esters to obtain a jet fuel blend stock and (ii) the C16 or longer fuel esters to obtain a diesel blend stock.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 23, 2012
    Applicant: Heliae Development, LLC.
    Inventor: Aniket Kale
  • Publication number: 20120029100
    Abstract: Strongly acidic cation exchangers with high mechanical, osmotic and oxidation stability can be prepared by sulfonating bead polymers formed from one or more vinylaromatic monomer(s), one or more crosslinker(s) and from 0.2 to 20% by weight of one or more vinyl ethers and/or vinyl esters.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Inventors: Pierre Vanhoorne, Hans-Jürgen Wedemeyer
  • Publication number: 20120029184
    Abstract: A method of isolating nutraceuticals products from algae is provided. A method of isolating carotenoids and omega-3 rich oil from algae includes dewatering substantially intact algal cells to make an algal biomass and adding a first ethanol fraction to the algal biomass. The method also includes separating a first substantially solid biomass fraction from a first substantially liquid fraction comprising proteins and combining the first substantially solid biomass fraction with a second ethanol fraction. The method further includes separating a second substantially solid biomass fraction from a second substantially liquid fraction comprising polar lipids and combining the second substantially solid biomass fraction with a third ethanol solvent fraction.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Applicant: Heliae Develoopment, LLC
    Inventor: Aniket Kale
  • Publication number: 20120021481
    Abstract: Methods and electroporation devices for electrical treatment of algal cell cultures for release of lipids and proteins are described herein. The method of the present invention exploits the differences in electrical time constants for the media inside the cell and outside the cell to produce a net force to cause cellular lysis and extract cellular components. The method of the present invention can be used in the treatment of flocculated as well as unflocculated algal cell cultures. The device of the present invention provides efficient cell lysing in a low-energy cost set-up.
    Type: Application
    Filed: July 19, 2011
    Publication date: January 26, 2012
    Inventors: Robert E. Hebner, Kent Davey, Michael D. Werst, Rhykka Connelly
  • Publication number: 20120009624
    Abstract: The invention relates to a protein particle comprising chimeric protein having an aggregating part capable of forming or aggregating into a substantially insoluble protein particle when expressed by a cell; and a functional part capable of binding to, or being bound by, a target compound. Affinity matrixes comprising the protein particle are also provided.
    Type: Application
    Filed: December 3, 2007
    Publication date: January 12, 2012
    Inventors: Jens Sommer-Knudsen, Moreland D. Gibbs
  • Publication number: 20120004592
    Abstract: Tissue solubilizing compositions are provided. The compositions comprise 3-(decyl dimethyl ammonio) propane sulfonate and polyethylene glycol dodecyl ether, such as tetraethylene glycol dodecyl ether. The compositions may be useful to solubilize tissue, including skin, mucosal membrane, and other tissue. The compositions may be further useful to preserve and recover analytes contained within the solubilized skin, mucosal membrane, and other tissue.
    Type: Application
    Filed: April 27, 2011
    Publication date: January 5, 2012
    Applicant: The Regents of the University of California
    Inventors: Samir Mitragotri, Sumit Pallwal, Makoto Ogura, Russell M. Lebovitz
  • Patent number: 8084068
    Abstract: The present invention describes a process to produce a composition containing 5?-ribonucleotides wherein a microorganism is subjected to autolysis under conditions at which a substantial part of the RNA remains in a form degradable into 5?-ribonucleotides and at which a substantial part of the RNA remains associated with the cell wall fraction. Said cell wall fraction is recovered by a solid/liquid separation method and the RNA associated with said wall fraction is converted into 5?-ribonucleotides. The present invention also describes compositions containing 5?-ribonucleotides and their use in food or feed.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: December 27, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Bertus Noordam, Jan Gerrit Kortes
  • Publication number: 20110294181
    Abstract: The invention provides a process for producing alcohol from a cellulosic material, said process comprising the steps of: (i) hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; (ii) extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first aqueous acidic solution containing said extraction solvent and (b) a residue containing sugars, (iii) subjecting said residue to an oligosaccharide cleavage reaction to yield an aqueous solution of fermentable sugars; (iv) fermenting said fermentable sugars and distilling alcohol from the resulting fermented mixture; (v) evaporating said extraction solvent from said first solution to yield (a) a second aqueous acid solution containing no more than 10% wt., preferably no more than 5% wt.
    Type: Application
    Filed: October 2, 2009
    Publication date: December 1, 2011
    Applicant: WEYLAND AS
    Inventor: Karl Ragnar Weydahl
  • Patent number: 8052953
    Abstract: A method for recovering sulfuric acid from concentrated acid hydrolysate of plant cellulose material is disclosed. In some of the examples, the concentrated acid hydrolysate is mixed with a liquid organic precipitant, with the sugars in the hydrolysate being precipitated and separated out. The remainder is sulfuric acid and an organic solvent solution. The organic solvent is then separated by distillation or extraction, thereby obtaining the pure sulfuric acid solution. This precipitation method can recover above 90% sugars and acids with a small amount of organic precipitant, which greatly reduces the recovery cost.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: November 8, 2011
    Inventor: Peihao Chen
  • Publication number: 20110245491
    Abstract: The invention relates to a three-profile chromatographic sequential SMB process of separating and recovering products such as sugars and betaine from multicomponent feed solutions. In the process of the invention, product fractions and optionally recycle fractions are collected from several positions of the chromatographic separation system. The process of the invention may be applied to the separation of sucrose and betaine from sugar beet based solutions and to the separation of sugars, e.g. xylose, from plant-based hydrolysates, for example.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 6, 2011
    Applicant: Danisco A/S
  • Patent number: 8030481
    Abstract: Exemplary embodiments of this invention encompass a method for purifying a substantially crude stevioside, methods for preparing polymorphic and amorphous forms of stevioside, and the polymorphic and amorphous forms prepared therefrom.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: October 4, 2011
    Assignee: The Coca-Cola Company
    Inventors: Indra Prakash, Mani Upreti
  • Publication number: 20110237790
    Abstract: The present invention relates to a method of producing D-psicose crystals from a D-psicose solution by using supersaturation.
    Type: Application
    Filed: March 22, 2011
    Publication date: September 29, 2011
    Inventors: Kang Pyo LEE, Sang Hoon SONG, Seung Won PARK, Sung Bo KIM, Young Ho HONG, Joo Hang LEE, Taek Beom KIM, Jun Gap AN, Jung Hoon KIM
  • Patent number: 8003352
    Abstract: The invention relates to a process for obtaining a product sugar stream from a cellulosic biomass, comprising pretreating the cellulosic biomass to hydrolyze a portion of the cellulose and hemicellulose to produce glucose, acetic acid and a sugar monomer, adding base to the pretreated cellulosic biomass to produce inorganic salt and acetate salt; hydrolyzing the neutralized cellulosic biomass with cellulase enzymes and separating insoluble residue from the resulting sugar stream; treating the clarified sugar stream using exclusion chromatography at a pH of 5 to 10 to produce a product sugar stream.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: August 23, 2011
    Assignee: Iogen Energy Corporation
    Inventors: Brian Foody, Jeffrey S. Tolan
  • Publication number: 20110201023
    Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 18, 2011
    Inventors: Thomas Braulke, Sven Müller-Loennies
  • Patent number: 7998937
    Abstract: The present invention relates to a flavonoid compound having an antiviral activity, more particularly to a flavonoid compound obtained by extracting Houttuynia cordata with methanol and separating/purifying with chromatography, a method for efficient extraction and purification of the same and an antiviral composition comprising the compound as an active ingredient.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: August 16, 2011
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Dur Han Kwon, Wha Jeong Choi, Choong Hwan Lee, Jin Hee Kim, Man Bae Kim
  • Publication number: 20110184165
    Abstract: The invention relates to aggregate zeolitic adsorbents based on faujasite X type zeolite powder having a low silica content and small crystals, exchanged with barium or based on faujasite X type zeolite having a low silica content and small crystals, exchanged with barium and potassium. The invention also relates to the method for preparing said aggregate zeolitic adsorbents, and also their uses for separating sugars, polyhydric alcohols, isomers of substituted toluene, cresols, or for recovering very high purity paraxylene.
    Type: Application
    Filed: December 16, 2008
    Publication date: July 28, 2011
    Applicants: Ceca S.A., Institut Francais Du Petrole
    Inventors: Ludivine Bouvier, Stéphane Kieger, Catherine Laroche, Philibert Leflaive, Tom Frising
  • Patent number: 7985874
    Abstract: A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: July 26, 2011
    Assignee: Sumitomo Bakelite Company, Ltd.
    Inventors: Shinichiro Nishimura, Hideyuki Shimaoka
  • Publication number: 20110178290
    Abstract: A process for the co-production of gaseous HCl and a salt product comprising a cation and an anion, which process comprises the steps of a. providing an aqueous solution comprising protons, chloride anions, and cations and anions of the salt product, b. bringing the solution into contact with a substantially immiscible extractant, the extractant comprising: 1) an oil soluble amine, which amine is substantially water insoluble both in free and in salt form; and 2) a carrier solvent for the amine; whereupon HCl selectively transfers to the extractant to form an HCl-carrying extractant and a chloride depleted aqueous solution containing the salt product; c. separating the HCl-carrying extractant from the chloride-depleted aqueous solution; and d. distilling HCl from the separated HCl-carrying extractant to form gaseous HCl and HCl depleted extractant.
    Type: Application
    Filed: February 28, 2011
    Publication date: July 21, 2011
    Applicant: HCL CLEANTECH LTD.
    Inventors: Avram BANIEL, Aharon EYAL
  • Publication number: 20110172411
    Abstract: A process for the separation of a xylose-containing, lignosulphonate-containing Ca-sulfite spent liquor is provided. The process comprises a first step of: (A) chromatographic separation of the Ca- or Mg-sulfite spent liquor using a single pass through a batch-type long resin bed chromatography column having a strong acid cation exchange resin as a separation medium. The ratio of the bed length:mean resin bead diameter of the column is 10,000-40,000. This step yields •a first xylose-rich fraction having a xylose content 50-70 wt. % based on dry solids and • a lignosulphonate-rich fraction. The process further comprises a step of: (B) crystallizing xylose from the first xylose rich fraction by using a crystallization method comprising (i) boiling crystallization; (ii) cooling crystallization or (iii) a combination of (i) and (ii) to obtain a first batch of crystalline xylose and a first xylose run-off.
    Type: Application
    Filed: June 26, 2008
    Publication date: July 14, 2011
    Applicant: DANISCO A/S
    Inventors: Heikki Heikkila, Jari Lewandowski
  • Publication number: 20110159040
    Abstract: An aspect of the present invention provides for methods for identifying novel immunogens that when administered as vaccines elicit a cellular or humoral immunogenic response. In a particular embodiment, a method identified pneumococcal T-cell immunogens that elicit systemic IL-17A responses, and reduce or protect against pneumococcal colonization.
    Type: Application
    Filed: December 30, 2010
    Publication date: June 30, 2011
    Inventors: Richard Malley, Yingjie Lu, Kristin L. Moffitt
  • Patent number: 7968705
    Abstract: The present invention describes a composition comprising at least 55% w/w (on sodium chloride free dry matter weight) of 5?-ribonucleotides and a process for the production of this composition comprising the steps of: (i) treating microbial cells to release the cell contents comprising RNA; (ii) separating the RNA present in the released cell content from other soluble cell material; and (iii) converting the separated RNA into 5?-ribonucleotides.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: June 28, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Bertus Noordam, Jan Gerrit Kortest
  • Patent number: 7955819
    Abstract: A process for preparing asparagine-linked oligosaccharide derivatives including the steps of: (a) treating a delipidated egg yolk with a protease to obtain a mixture of peptide-linked oligosaccharides, (b) treating the mixture of peptide-linked oligosaccharides with a peptidase to obtain a mixture of asparagine-linked oligosaccharides, (c) introducing a lipophilic protective group into the asparagine-linked oligosaccharides in the mixture to obtain a mixture of asparagine-linked oligosaccharide derivatives, and (d) subjecting the mixture of asparagine-linked oligosaccharide derivatives to chromatography to separate the mixture into individual asparagine-linked oligosaccharide derivatives.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: June 7, 2011
    Assignee: Otsuka Chemical Holdings Co., Ltd.
    Inventor: Kazuhiro Fukae
  • Publication number: 20110130551
    Abstract: A one-step process for the lysis of microalgae cell walls and separation of the cellular lipids for use in biofuel production by utilizing a hydrophilic ionic liquid, 1-butyl-3-methylimidazolium. The hydrophilic ionic liquid both lyses the microalgae cell walls and forms two immiscible layers, one of which consists of the lipid contents of the lysed cells. After mixture of the hydrophilic ionic liquid with a suspension of microalgae cells, gravity causes a hydrophobic lipid phase to move to a top phase where it is removed from the mixture and purified. The hydrophilic ionic liquid is recycled to lyse new microalgae suspensions.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 2, 2011
    Applicant: Streamline Automation, LLC.
    Inventors: Roberto Di Salvo, Alton Reich, H. Waite H. Dykes, Rodrigo Teixeira
  • Patent number: 7951937
    Abstract: A process of azeotropic removal of dimethylformamide, abbreviated as DMF, from a process stream containing DMF requiring its removal, is described wherein the said Process Stream being obtained in a process for preparation of 4,1?,6? trichlorogalactosucrose, abbreviated as TGS, or TGS-6-ester including TGS-6-acetate or TGS-6-benzoate, comprising steps of (a) evaporation of the said process stream under reduced pressure to a concentrate to effect removal of a part of DMF azeotropically, (b) diluting the concentrate obtained at the end of step (a.) of this claim with water, preferably to about 5 to 10 times the volume of the said concentrate, and (c) repeating the cycles of evaporation under reduced pressure and dilution with water for more number of times until content of DMF in the concentrated mass is reduced to 0.5% or less of the concentrate.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: May 31, 2011
    Assignee: V.B. Medicare Private Limited
    Inventors: Rakesh Ratnam, Sundeep Aurora, Batchu Chandrasekhar
  • Publication number: 20110124034
    Abstract: The subject invention relates to novel methods for treating microbial biomass and uses thereof. In particular, this invention provides methods for production of lipids using ionic liquid solutions, and subsequent uses of biomass components in food, biofuels, and as chemical precursors. Further, this invention provides methods for recovering the ionic liquids using an antisolvent, thus enables subsequent reuse of the ionic liquids In addition, this invention provides practical methods for determining the lipid content of a biomass and screening potential lipid-producing microbial classes. This invention also provides a method of chemical dewatering the lipid-rich algae cells by ionic liquids with its subsequent reuse.
    Type: Application
    Filed: November 24, 2010
    Publication date: May 26, 2011
    Inventors: ADELHEID R. KUEHNLE, Norie Anne B. Nolasco
  • Patent number: 7943766
    Abstract: A novel low-carbohydrate digestible hydrocolloidal composition is separated from a cereal-based substrate by means of a specific sequence of steps for treating an aqueous slurry of the substrate. These all-natural compositions are low in digestible carbohydrates, principally starches, and rich in soluble fiber, principally ?-glucan, as well as proteins. The hydrocolloidal products are recovered in high yields, are smooth in texture, have unexpected thickening properties, have a bland flavor, and are useful for texturizing food, especially bakery products. These hydrocolloidal products can also be used as food ingredients for increasing the nutritional level of foods and supplements.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: May 17, 2011
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: George E. Inglett
  • Patent number: 7943764
    Abstract: A method for isolating sulphated glycosaminoglycans washes a mechanically cleaned tissue, exposes tissue in a solution of 0.1M phosphate pH 5.8-6.0 buffer heated to a temperature of 65° C. for 30 minutes, overcooks the tissue in activated 0.1-0.4% papain at 65° C. for 6-24 hours, cools the papain digest to 4° C., removes fats and undigested tissue residues, selectively isolates the sulphated glycosaminoglycans for 4-10 hours on a solid carrier, obtained from bone tissue collagen with particle sizes ranging from 0-01 to 0.35 cm3, washes the carrier with 0.05-0.1 N-hydrochloric acid, degreases and eluates the carrier with a solution of 0.6-0.15 N-mineral salt in 0.8 N-acetic acid or in 0-01-0-025 N-alkali liquor, precipitates the sulphated glycosaminoglycans with ethanol, centrifuges with 1500 r.p.m. for 15 minutes at a temperature of 4° C., washes the precipitate with ethanol or acetone, and dries and sterilizes the precipitate.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: May 17, 2011
    Inventor: Andrey Fedorovich Panasyuk
  • Publication number: 20110089033
    Abstract: A method of preparing a sugar chain sample, for reducing unreacted labeling reagent in a sample solution containing a labeled sugar chain, includes (process 1) a process of bringing the sample solution containing the labeled sugar chain into contact with monolithic silica, so as to allow the monolithic silica to adsorb a sugar chain component; (process 2) a process of washing the monolithic silica with a washing liquid; and (process 3) a process of bringing the monolithic silica into contact with an eluant, so as to elute the adsorbed sugar chain.
    Type: Application
    Filed: June 10, 2009
    Publication date: April 21, 2011
    Applicant: Sumitomo Bakelite Co., Ltd.
    Inventors: Hideyuki Shimaoka, Midori Abe
  • Patent number: 7923552
    Abstract: The invention provides a high throughput, high purity, high yield system and method of isolating and purifying rebaudioside A (“Reb A”), with acceptable water solubility for all commercial uses, from commercially available Stevia rebaudiana starting material. The invention also provides a means of maximizing yields of 99+% purity Reb A based on the attributes of a given batch of Stevia starting material. The Reb A produced by the invention is water soluble, devoid of bitterness heretofore associated with rebaudioside sweeteners, non-caloric, and suitable for use as a reagent and as an ingredient in orally consumed products, e.g., as a sweetener, flavor enhancer, and flavor modifier.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: April 12, 2011
    Assignee: SGF Holdings, LLC
    Inventors: Mel Clinton Jackson, Gordon James Francis, Robert Gordon Chase
  • Publication number: 20110077393
    Abstract: Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.
    Type: Application
    Filed: August 9, 2010
    Publication date: March 31, 2011
    Inventors: Gerald B. Hammond, Bo Xu
  • Publication number: 20110065159
    Abstract: High-yielding method for chemical hydrolysis of lignocellulose into monosaccharides. The process of the invention can additionally be applied to cellulose, xylan and related biomass polysaccharides, such as galactan, mannan, or arabinan. The method is employed for hydrolysis of a biomass polysaccharide substrate. The process is carried out in an ionic liquid in which cellulose is soluble in the presence of catalytic acid at a temperature sufficiently high to initiate hydrolysis. Water is added to the reaction mixture after initiation of hydrolysis at a rate controlled to avoid precipitation yet avoid undesired sugar dehydration products such ad HMF. Hydrolysis product is useful as feedstock for fermentations including fermentation processes for ethanol, butanol and other fuels.
    Type: Application
    Filed: June 24, 2010
    Publication date: March 17, 2011
    Inventors: Ronald T. RAINES, Joseph B. BINDER
  • Publication number: 20110065148
    Abstract: The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in particular Aleuria aurantia lectin. Furthermore the invention relates to methods for producing the peptides, assays using the peptides for diagnosis of disorders, as well as methods using the peptides for separation and detection of fucose-containing compounds.
    Type: Application
    Filed: May 8, 2009
    Publication date: March 17, 2011
    Inventors: Peter Pahlsson, Ingvar Ryden
  • Publication number: 20110053868
    Abstract: Disclosed is L-glucose monohydrate and compositions thereof. Also disclosed are methods for making L-glucose monohydrate and compositions thereof. Further disclosed are methods for colonic cleansing using L-sugars, such as L-glucose monohydrate, and compositions and kits useful for colonic cleansing.
    Type: Application
    Filed: June 3, 2010
    Publication date: March 3, 2011
    Applicant: Axcan Pharma, Inc.
    Inventors: Edward DELANEY, Mohammad Rahman, Michael Caswell
  • Publication number: 20110046364
    Abstract: The present invention relates to a method of labeling a sugar chain, used for labeling a sugar chain contained in a biological sample, aimed at simplifying a process of isolating a sugar chain from a biological sample and labeling it, which includes (a) trapping a sugar chain in a sugar-trapping substance, which is a substance for specifically trapping a sugar chain from a biological sample; (b) washing the sugar-trapping substance having the sugar chains trapped thereon; (c) releasing the sugar chain from the sugar-trapping substance; and (d) labeling the released sugar chain, wherein the processes (a), (b), (c) and (d) are conducted sequentially in a single reaction vessel.
    Type: Application
    Filed: April 28, 2009
    Publication date: February 24, 2011
    Inventors: Midori Abe, Hideyuki Shimaoka, Hiromitsu Kuramoto
  • Patent number: 7868166
    Abstract: A process is described for the continuous preparation and/or workup of polysaccharide derivatives by reaction and/or conditioning in a suspension with liquid reaction partners, in which, in accordance with FIG. 1, a) a preferably pumpable suspension stream of solids SE and liquid phase LE, if appropriate preheated to 185° C.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: January 11, 2011
    Inventors: Volker Eckhardt, Martin Lohrie, Bernd Schriewer, Holger Tanneberger
  • Patent number: 7862744
    Abstract: The present invention provides a method for preparing DMF for sucralose production, including, e.g., isolating DMF from a composition comprising DMF, water, and methanol, using a single-tower rectification system. In various embodiments of the present invention, the composition, after the removal of water and methanol, may be further dried/dehydrated, such as, by using a dehydration agent and/or filtration. The resulting substantially pure DMF may comprise at least about 98-99% DMF. The present invention further provides a method of preparing a composition comprising anhydrous sucrose for sucralose production, which may comprise mixing regular sucrose with a water-containing DMF composition, and drying the resulting sucrose-DMF composition. Also provided is a single-tower separation system for isolating DMF from a composition comprising DMF, water, and methanol.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: January 4, 2011
    Assignee: Mamtek International Limited
    Inventors: David Losan Ho, Zhenghao Wan
  • Publication number: 20100324282
    Abstract: This invention provides a method for separating a heteropolyacid from a monosaccharide in the presence of water. The method comprises separating a heteropolyacid from a mixture containing a monosaccharide, the heteropolyacid and water using an organic solvent selected from the group consisting of linear C2-4 alkyl ethyl ether and linear or branched C6-12 alcohol.
    Type: Application
    Filed: June 16, 2010
    Publication date: December 23, 2010
    Inventors: Masayoshi MURAMATSU, Satoshi Yoneda, Tsuruyo Shimazaki, Shusei Obata
  • Publication number: 20100317847
    Abstract: The invention relates to a crystalline form of 4-(?-D-glucopyranos-1-yl)-1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
    Type: Application
    Filed: October 26, 2007
    Publication date: December 16, 2010
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Tanja M. Butz, Hans-Juergen Martin
  • Publication number: 20100298265
    Abstract: There is described an inclusion complex of raloxifene hydrochloride and ?-cyclodextrin in the solid phase having a specific X-ray powder diffraction spectrum. The invention also relates to a process for obtaining the raloxifene hydrochloride inclusion complex with ?-cyclodextrin of the invention. The complex of the invention is employed as a pharmaceutical ingredient in the treatment of osteoporosis, specifically postmenopausal osteoporosis.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 25, 2010
    Inventors: Massimo Ferrari, Pietro Carlo Gargani