Unsubstituted Or Hydrocarbyl Substituted Only, Or Salt Thereof Patents (Class 546/348)
-
Patent number: 5714605Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: GrantFiled: October 10, 1995Date of Patent: February 3, 1998Assignees: Monsanto Company, G. D. SearleInventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
-
Patent number: 5714491Abstract: Peptidyl derivatives are disclosed that are orally active metalloproteinase inhibitors. The peptidyl derivatives have a selective gelatinase action, have a long duration of action, and are useful in the prophylaxis or treatment of diseases or disorders in which stromelysis, collagenase or gelatinase have a role, for example, in the treatment of cancer to control the development of tumor metastases.Type: GrantFiled: February 6, 1995Date of Patent: February 3, 1998Assignee: Celltech Therapeutics LimitedInventors: John Richard Morphy, Thomas Andrew Millican
-
Patent number: 5691381Abstract: The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and inhibit the production of tumor necrosis factor alpha, and for the treatment of arthritis and other related inflammatory diseases.Type: GrantFiled: April 16, 1996Date of Patent: November 25, 1997Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Irina Cipora Jacobson, Carl Peter Decicco, Robert Joseph Cherney
-
Patent number: 5676923Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.Type: GrantFiled: June 7, 1995Date of Patent: October 14, 1997Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
-
Patent number: 5670440Abstract: A catalyst composition comprisinga) a palladium compound,b) an anion, andc) an asymmetric phosphorus bidentate ligand of the general formula R.sup.5 R.sup.6 P-Q-CHR.sup.9 -PR+7R.sup.8, wherein Q is a 1,2-ferrocenyl bridging group, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are identical or different optionally polar substituted hydrocarbyl groups and R.sup.9 is hydrogen or an optionally polar substituted hydrocarbyl group;a process for the preparation of linear alternating copolymers of carbon monoxide with an aliphatic -olefin having at least 3 and at most 10 carbon atoms, which process comprises contacting a mixture of the monomers with a said catalyst composition; and a linear alternating copolymer of carbon monoxide with an aliphatic -olefin having at least 3 and at most 10 carbon atoms which copolymer has an isotacticity of 95% or more.Type: GrantFiled: October 22, 1996Date of Patent: September 23, 1997Assignee: Shell Oil CompanyInventors: Simona Bronco, Giambattista Consiglio, Silvia Di Benedetto, Eit Drent, Hero Jan Heeres, Johannes Adrianus Maria Van Broekhoven, Marinus Johannes Reynhout
-
Patent number: 5633257Abstract: Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR.sup.1, wherein R.sup.1 is an optionally substituted alkyl group; X is --O--, --S--, or --N(R.sup.6), wherein R.sup.6 is a hydrogen atom or an optionally substituted alkyl group; R.sup.2 is an optionally substituted cycloalkyl or cycloalkenyl group; R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or an optionally substituted alkyl, --CO.sub.2 R.sup.7 (wherein R.sup.7 is a hydrogen atom, am optionally substituted alkyl, aralkyl, aryl, aryloxyalkyl, alkanoyloxyalkyl or aroyloxyalkyl group), --CONR.sup.8 R.sup.9 (where R.sup.8 and R.sup.9, which may be the same or different, is as defined for R.sup.7), --CSNR.sup.8 R.sup.9, --CN or --CH.sub.2 CN group; Z is --(CH.sub.2).sub.n -- where n is zero or an integer 1, 2 or 3; R.sup.Type: GrantFiled: March 9, 1994Date of Patent: May 27, 1997Assignee: Celltech Therapeutics LimitedInventors: Graham J. Warrellow, Valerie A. Cole, Rikki P. Alexander
-
Patent number: 5629323Abstract: Amide Derivatives of formula (I) wherein R.sup.1 is a mono or bicyclic heteroaryl radical, R.sup.2 is cycloalkyl, R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl, and R.sup.5 is a group of formula (A) or (B) or (C): R.sup.8 --CH.sub.2 --CH.sub.2 -- or (D) or (E): R.sup.9 OCH.sub.2 CHOHCH.sub.2 -- or (F): R.sup.9 OCH.sub.2 CH.sub.2 -- and their pharmaceutically acceptable salts are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics.Type: GrantFiled: May 25, 1995Date of Patent: May 13, 1997Assignee: John Wyeth & Brother, Ltd.Inventors: Ian A. Cliffe, Anderson D. Ifill
-
Patent number: 5618931Abstract: Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification have retinoid-like biological activity.Type: GrantFiled: December 29, 1994Date of Patent: April 8, 1997Assignee: AllerganInventors: Richard L. Beard, Min Teng, Alan T. Johnson, Vidyasagar Vuligonda, Roshantha A. Chandraratna
-
Patent number: 5608112Abstract: Nitrogen-containing substituents of aliphatic or aromatic compounds can be reduced by treatment with a reagent comprising (i) at least one complex of a transition metal of group 4 or 5 with a multidentate or unidentate organic or inorganic ligand and (ii) a reducing agent. The reaction is conducted optionally in the presence of an aliphatic or aromatic amine, and/or in the presence of an inert organic solvent.Type: GrantFiled: July 10, 1995Date of Patent: March 4, 1997Assignee: The Trustees of Princeton UniversityInventor: Jeffrey Schwartz
-
Patent number: 5599522Abstract: A radical compound of formula Ia.C(Ar.sup.12).sub.3 (Ia)wherein:each Ar.sup.12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar.sup.12 being a group Ar.sup.1 ;each group Ar.sup.1 represents a 6-membered ring optionally substituted at the or any ortho carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4, at the or any meta carbon by a group R.sup.2 or R.sup.3, and at any para carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4,with the proviso that no more than two ring carbons are unsubstituted;each of R.sup.1, R.sup.2, R.sup.3 or R.sup.4, which may be the same or different, independently represents a group of formula --M, --XM, --XAr.sup.2 or --Ar.sup.2 ;M represents a water solubilizing group, each group X, which may be the same or different, represents an oxygen or sulphur atom or a NH or CH.sub.2 group.Type: GrantFiled: September 2, 1992Date of Patent: February 4, 1997Assignee: Nycomed Imaging ASInventors: Mikkel J.o slashed.rgensen, Frode Rise, Sven Andersson, Torsten Almen, Klaes Golman
-
Patent number: 5578595Abstract: Novel 2-(2,2-difluorocyclopropyl)-acetic acid derivatives of formula I ##STR1## wherein A is oxygen or --NR.sub.1 --,B is C.sub.2 -C.sub.6 alkylene,D is oxygen, sulfur or --O--CH.sub.2 --,E is phenyl; phenyl substituted by from one to three substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 haloalkyl and C.sub.1 -C.sub.4 alkoxy; a five-membered aromatic heterocycle having from one to three hetero atoms selected from the group nitrogen, oxygen and sulfur; a five-membered aromatic heterocycle having from one to three hetero atoms selected from the group nitrogen, oxygen and sulfur that is substituted by one or two substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.3 haloalkyl; a six-membered aromatic heterocycle having from one to three nitrogen atoms; or a six-membered aromatic heterocycle having from one to three nitrogen atoms that is substituted by one or two substituents selected from the group halogen, C.sub.1 -C.sub.4 alkyl and C.Type: GrantFiled: March 21, 1995Date of Patent: November 26, 1996Assignee: Ciba-Geigy CorporationInventor: Manfred B oger
-
Patent number: 5569660Abstract: 3-(2,2-Dimethyl-propyl)-pyridine is used to impart, improve or modify the odor properties of a variety of consumer products. In particular, it develops fruity-fresh type notes.Type: GrantFiled: May 17, 1995Date of Patent: October 29, 1996Assignee: Firmenich SAInventors: Roger L. Snowden, Pierre-Alain Blanc
-
Patent number: 5565573Abstract: The present invention provides a method to prepare epibatidine or an analog thereof comprising reacting a bicyclic olefin or diene, such as an azanorbornene, with an aryl or heteroaryl halide or triflate in the presence of a catalytic amount of Pd(O) and a formate salt.Type: GrantFiled: November 12, 1993Date of Patent: October 15, 1996Assignee: Iowa State University Research Foundation, Inc.Inventor: Richard C. Larock
-
Patent number: 5559248Abstract: This invention relates to a compound of formula I ##STR1## in which T is --CONH-- or --CH.dbd.CH--;R.sup.a and R.sup.b are independently C.sub.1-6 alkyl;R.sup.c is C.sub.1-6 alkyl or hydrogen; andR is heteroaryl and these compounds are useful in preventing and treating skin disorders.Type: GrantFiled: April 5, 1995Date of Patent: September 24, 1996Assignee: Bristol-Myers Squibb Co.Inventors: John E. Starrett, Jr., David R. Tortolani, Muzammil M. Mansuri, Nicholas A. Meanwell
-
Patent number: 5552549Abstract: Chlorinated aromatic compounds are dechlorinated in a simple and inexpensive manner by heating them to 300.degree. to 450.degree. C. in a salt melt in the presence of water and/or water vapor and carbon.Type: GrantFiled: September 29, 1994Date of Patent: September 3, 1996Assignee: Bayer AktiengesellschaftInventors: Christian Rasp, Helmut Waldmann, Hans-Joachim Traenckner
-
Patent number: 5525436Abstract: The subject invention relates to solid polymer electrolyte membranes comprising proton conducting polymers stable at temperatures in excess of 100.degree. C., the polymer being basic polymer complexed with a strong acid or an acid polymer. The invention further relates to the use of such membranes in electrolytic cells and acid fuel cells. Particularly, the invention relates to the use of polybenzimidazole as a suitable polymer electrolyte membrane.Type: GrantFiled: November 1, 1994Date of Patent: June 11, 1996Assignee: Case Western Reserve UniversityInventors: Robert F. Savinell, Morton H. Litt
-
Patent number: 5523469Abstract: This invention relates to levogyral isomers of alkylammonium (amino-3 phenyl)-1 ethanesulphonate derivatives of formula (I) in which R+ denotes a tetraalkylammonium or trialkylphenylalkylammonium residue. The invention also concerns the preparation and use of said derivatives.Type: GrantFiled: March 10, 1995Date of Patent: June 4, 1996Assignee: Rhone-Poulenc Rorer S.A.Inventor: Claude Guyon
-
Patent number: 5521309Abstract: An anionic polymerization initiator includes the C-lithio reaction product of an organolithium compound and a tertiary-amino allyllithium or a tertiary-amino xylyllithium. When used in an anionic polymerization, a functional group from the initiator is incorporated onto the head of the growing polymer and a lithium atom is incorporated at the "living" end of the polymer chain prior to quenching. The initiator may be used to polymerize a monomer(s) including diolefin monomers, monovinyl aromatic monomers and trienes, and the living ends of the polymers are effectively maintained even at temperatures of up to 300.degree. F. and higher. Such polymers exhibit an increased efficiency in coupling termination reactions, and products prepared from such polymers exhibit improved hysteresis characteristics. Products such as tires and the like can be prepared from such polymers and from vulcanizable elastomer compositions employing the polymers.Type: GrantFiled: December 23, 1994Date of Patent: May 28, 1996Assignee: Bridgestone CorporationInventors: Thomas A. Antkowiak, James E. Hall, David F. Lawson, John R. Schreffler, Mark L. Stayer, Jr.
-
Patent number: 5514683Abstract: The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.Type: GrantFiled: August 9, 1994Date of Patent: May 7, 1996Assignee: James Black Foundation LimitedInventors: Sarkis B. Kalindjian, Caroline M. R. Low, Iain M. McDonald, Robert A. D. Hull, Nigel P. Shankley, Ildiko M. Buck, Katherine I. M. Steel, Jonathan M. R. Davies, David J. Dunstone, Elaine A. Harper, Michael J. Pether, Michael J. Bodkin, Matthew J. Tozer, Martin L. Hudson
-
Patent number: 5498718Abstract: A process for preparing certain 1,3,4,4-tetrasubstituted-1,2,3,4-tetrahydropyridines is provided as well as certain 4-carbonate-1,3,4-trisubstituted piperidines.Type: GrantFiled: December 20, 1994Date of Patent: March 12, 1996Assignee: Eli Lilly and CompanyInventor: John A. Werner
-
Patent number: 5459264Abstract: A method for reducing an .alpha.,.beta.-unsaturated ketone of the present invention includes the step of treating the .alpha.,.beta.-unsaturated ketone with a silyl compound in the presence of a Lewis acid and alcohol to selectively reduce the carbonyl group of the .alpha.,.beta.-unsaturated ketone. According to this method, a deoxy-compound can be obtained from the .alpha.,.beta.-unsaturated ketone by selectively reducing the carbonyl group without reducing an .alpha.,.beta.-unsaturated bond.Type: GrantFiled: December 17, 1993Date of Patent: October 17, 1995Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Mitsuru Imuta, Makoto Kobayashi, Teruo Iizuka
-
Patent number: 5401856Abstract: A cyclocarbonylation process for making pyrrolidones under mild temperature and pressure conditions is disclosed. In the process, an allylic amine reacts with carbon monoxide in the presence of a rhodium carbonyl catalyst and an amount of a pyridine promoter effective to enhance the yield of pyrrolidone obtained in the process compared with the yield obtained in the absence of the promoter. The process can be used to make N-methyl-2-pyrrolidone from N-methylallylamine.Type: GrantFiled: February 28, 1994Date of Patent: March 28, 1995Assignee: ARCO Chemical Technology, L.P.Inventors: Roger A. Grey, Diandre Armstead
-
Patent number: 5380713Abstract: This invention relates to novel arginine aldehydes, their salts and hydrates, which compounds selectively exhibit serine proteases inhibitory activity, are highly stable in aqueous solutions, and are useful for anti-trypsin and anti-thrombin activity.Type: GrantFiled: April 11, 1994Date of Patent: January 10, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Neelakantan Balasubramanian, Denis R. St. Laurent
-
Patent number: 5374732Abstract: A substituted N-fluoropyridiniumsulfonate of the formula: ##STR1## in which R.sup.1 is a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl or haloalkyl group, and R.sup.2 is a C.sub.1 -C.sub.4 alkyl or haloalkyl group, which is an effective fluorinating agent.Type: GrantFiled: July 31, 1992Date of Patent: December 20, 1994Assignee: Daikin Industries, Ltd.Inventors: Teruo Umemoto, Ginjiro Tomizawa
-
Patent number: 5360911Abstract: A novel process is disclosed for producing stilbazolium salts. Said novel process employs a heterocyclic amine catalyst, such as pyrrolidine, an alkylated pyridine salt and a substituted benzaldehyde which unexpectedly results in increased reaction rates and product yields.Type: GrantFiled: June 17, 1993Date of Patent: November 1, 1994Assignee: General Electric CompanyInventors: Eugene P. Boden, Peter D. Phelps, Kevin R. Stewart
-
Patent number: 5336441Abstract: A method for inhibiting corrosion of ferrous surfaces in an acidic, aqueous medium is disclosed. The method comprises incorporating into the medium a corrosion-inhibiting amount of a pyridine salt composition (comprising a quaternary pyridine salt composition and/or a pyridine.HCL salt composition) and a cationic surfactant that forms a bilayer on the ferrous surfaces in the medium. Highly quaternized pyridine salt compositions useful in such method and a method for preparation of such compositions are also disclosed.Type: GrantFiled: May 29, 1991Date of Patent: August 9, 1994Assignee: Petrolite CorporationInventors: Sayed S. Shah, William F. Fahey, Bernardus A. Oude Alink
-
Patent number: 5292761Abstract: The invention relates to compounds of formula I: ##STR1## in which R.sub.1 represents a naphthyl radical, a dihydronaphthyl radical, a tetrahydronaphthyl radical, a quinolyl radical or a 1,4-benzodioxanyl radical, A represents a single bond, a double bond, a methylene radical, a radical of formula z.sub.1 :--CH.dbd. (z.sub.1)or a radical of formula z.sub.2 :.dbd.Ch-- (z.sub.2)the ring B represents a piperidyl radical, a pyrrolidinyl radical, or a 1,2,3,6-tetrahydropyridyl radical, and R.sub.2 represents: a hydrogen atom, a benzyl radical, or an alkyl radical having 1 to 6 carbon atoms, on condition that in one of these cases R.sub.1 is other than a naphthyl (y.sub.1), dihydronaphthyl (y.sub.2) or tetrahydronaphthyl (y.sub.3) radical and B is other than a piperidinyl radical, or an aminoalkyl radical having 1 to 6 carbon atoms, a cyanoalkyl radical having 1 to 6 carbon atoms, or a radical of formula w.sub.1 : ##STR2## in which n is 1-6 and R.sub.Type: GrantFiled: November 5, 1992Date of Patent: March 8, 1994Assignee: Adir et CompagnieInventors: Gilbert Lavielle, Michel Laubie, Francis Colpaert
-
Patent number: 5254712Abstract: The invention relates to a process for the preparation of high yields of 5-oxohexane nitriles with minimum formation of 1 undesired isomer. Such nitriles may be utilized as starting materials for the preparation of pharmaceutical and agrochemical intermediates and as well as final products. The process comprises reacting a methyl ketone and an .alpha.,.beta.-unsaturated nitrile in the presence of a catalytically effective amount of a strong base. One of the products which may be created by the process is 2,4-dimethyl-5-oxohexane nitrile.Type: GrantFiled: June 24, 1992Date of Patent: October 19, 1993Assignee: Stamicarbon B.V.Inventors: Anna M. C. F. Castelijns, Henricus J. Arts, Richard Green
-
Patent number: 5250711Abstract: Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfatoethyl)amides of the Formula IHOC(O)--(CH.sub.2).sub.n --C(O)--N(R.sub.1)--CH.sub.2 CH.sub.2 SO.sub.3.sup.--+ HN(R.sub.2).sub.3 Iwherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl and phenyl, R.sub.2 is C.sub.1 -C.sub.8 alkyl or (R.sub.2).sub.3 when taken together with the nitrogen atom is pyridinyl; and n is an integer from 4 to 20, their preparation and use to prepare water-soluble esters of corticosteroids.Type: GrantFiled: January 12, 1990Date of Patent: October 5, 1993Assignee: The Upjohn CompanyInventor: Bruce A. Pearlman
-
Patent number: 5237116Abstract: A process and catalyst are disclosed for the catalyzed reaction of an organometallic reagent with a reactive halide in the presence of a diphosphine complex of a nickel carboxylate or sulfonate. The process can be employed in the synthesis of aromatic compounds such as bisbenzocyclobutenes.Type: GrantFiled: April 3, 1991Date of Patent: August 17, 1993Assignee: Shell Oil CompanyInventor: Larry S. Corley
-
Patent number: 5214027Abstract: Described is pyridine derivatives defined according to one of generic formula (I) ##STR1## wherein R.sup.2 represents isopropenyl group when R.sup.1 is methyl or ethyl group, R.sup.2 represents isopropenyl or acetyl group when R.sup.1 is isopropenyl group, R.sup.2 represents methyl group when R.sup.1 is isopropyl group and R.sup.2 represents isopropenyl, or isopropyl group when R.sup.1 is acetyl group; and perfumery composition containing the derivatives.Type: GrantFiled: April 3, 1992Date of Patent: May 25, 1993Assignees: Shiono Koryo Kaisha, Ltd., Lion CorporationInventors: Masakazu Ishihara, Tomoyuki Tsuneya, Minoru Shiga, Hiroshi Sato, Fumio Yoshida, Keiichi Yamagishi
-
Patent number: 5194619Abstract: The compounds of the formula I or Ia ##STR1## in which R.sup.1 is alkyl, aryl, alkoxy, alkenyl, arylalkyl, alkylaryl, aryloxy, fluoroalkyl, halogenoaryl, alkynyl, trialkylsilyl or a heteroaromatic radical,R.sup.2, R.sup.3 and R.sup.4, in addition to hydrogen, have the meanings given under R.sup.1 andR.sup.5 is hydrogen, alkyl, fluoroalkyl or alkenyl, can be obtained in a one-stage process by reaction of a compound II ##STR2## with (substituted) cyclopentadiene in the presence of a base. The compounds I and Ia are suitable as ligands for metallocene complexes which are used as catalysts in olefin polymerization.Type: GrantFiled: February 14, 1992Date of Patent: March 16, 1993Assignee: Hoechst AktiengesellschaftInventors: Dieter Reuschling, Jurgen Rohrmann, Gerhard Erker, Reiner Nolte, Michael Aulbach, Astrid Weiss
-
Patent number: 5175244Abstract: An improved process for the production of linear alternating polymers of carbon monoxide and at least one ethylenically unsaturated hydrocarbon employs a novel catalyst composition formed from a compound of palladium, the anion of a strong non-hydrohalogenic acid and a novel bidentate phosphine ligand wherein each phosphorus has an aliphatic group as one monovalent substituent and as another monovalent substituent a heteroaromatic group connected to the phosphorus by a ring carbon atom. The polymers are useful as thermoplastics.Type: GrantFiled: May 9, 1991Date of Patent: December 29, 1992Assignee: Shell Oil CompanyInventors: Petrus H. M. Budzelaar, Eit Drent
-
Patent number: 5159082Abstract: A process for producing an aromatic compound is disclosed, which comprises coupling an aromatic sulfinic acid or a salt thereof with an aromatic halogen compound having at least one halogen atom attached to the carbon atom of the aromatic nucleus thereof or a vinyl group-containing halogen compound having at least one halogen atom attached to the carbon atom of said vinyl group in the presence of a catalyst compound containing an element selected from platinum metals.Type: GrantFiled: June 25, 1990Date of Patent: October 27, 1992Assignee: Mitsubishi Kasei CorporationInventors: Keiichi Sato, Toru Okoshi
-
Patent number: 5148817Abstract: This invention provides tobacco and non-tobacco smoking compositions which contain a heterocyclic-hydroxy-substituted carboxylate compound as a flavorant additive.In one of its embodiments, this invention provides tobacco compositions which contain a heterocyclic-hydroxy-substituted carboxylic acid flavorant additive such as 2-(2-butyl)-3-hydroxy-3-methyl-3-(3-pyridyl)propionic acid: ##STR1## Under smoking conditions the above illustrated heterocyclic-hydroxy-substituted carboxylate additive and its pyrolysis products flavor the mainstream and sidestream smoke.Type: GrantFiled: November 7, 1980Date of Patent: September 22, 1992Assignee: Philip Morris IncorporatedInventors: Yoram Houminer, Harvey J. Grubbs
-
Patent number: 5149705Abstract: Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH or an ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.1 or a ketal derivative thereof where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 13, 1987Date of Patent: September 22, 1992Assignee: Allergan, Inc.Inventor: Roshantha A. S. Chandraratna
-
Patent number: 5134151Abstract: The present invention relates to novel 2-picolylamine derivatives of general formula I ##STR1## wherein R.sub.1 represents an alkyl or phenylalkyl radical; R.sub.2 is hydrogen, C.sub.1 -C.sub.4 acyl or C.sub.1 -C.sub.4 alkoxycarbonyl; R.sub.3 is either an electron pair, in which case t means nothing and q is 0, or R.sub.3 is hydrogen or C.sub.1 -C.sub.4, in which case t is (+) and q=1; Z is oxygen or an aminocarboniloxy group; X is O or S; m and n are 2-6; p is 0-3; A.sup.- is a pharmaceutically acceptable ion. These compounds are PAF antagonists and, consequently, useful in the treatment of the diseases in which this substance is involved.Type: GrantFiled: March 2, 1990Date of Patent: July 28, 1992Assignee: J. Uriach & CiaInventors: Javier Bartroli, Manuel Anguita, Elena Carceller
-
Patent number: 5126461Abstract: Process for ring opening compounds of the formula ##STR1## in which R.sup.1 is heteroaryl or aryl, R.sup.2 is a leaving group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently selected from hydrogen, alkyl, aralkyl, aryl, heteroaryl and alkenyl, provided that at least one of the groups R.sup.3 to R.sup.6 is other than hydrogen, by breaking the bond joining the carbon atom attached to R.sup.3 and the carbon atom attached to R.sup.6 in organic solution using silica, giving useful diene or allyl derivatives, certain of which are novel.Type: GrantFiled: November 14, 1990Date of Patent: June 30, 1992Assignee: Shell Research LimitedInventors: Mark S. Baird, Ian Bruce
-
Patent number: 5082940Abstract: Aromatic tertiary amines are oxidized by means of hydrogen peroxide in an inert solvent medium in the presence of a catalyst selected from metal selenium and compounds of selenium.The process is applied to the preparation of oxides of heterocyclic aromatic tertiary amines and oxides of non-heterocyclic tertiary amines, in which the nitrogen atom is substituted by at least 1 aromatic nucleus.Type: GrantFiled: September 5, 1990Date of Patent: January 21, 1992Assignee: Interox (Societe Anonyme)Inventors: Franz Legrand, Andre Lecloux, Paul Deschrijver
-
Patent number: 5080719Abstract: This invention privdes novel heteroaromatic compounds, and smoking compositions which contain an invention heteroaromatic compound as a flavorant-release additive as illustrated by the following additive structure: ##STR1## Under typical cigarette smoking conditions, 2-isopropylpyrazine and acetophenone are released as pyrolysis products, and enhance the flavor and aroma of the mainstream and sidestream smoke.Type: GrantFiled: September 24, 1987Date of Patent: January 14, 1992Assignee: Philip Morris IncorporatedInventors: Yoram Houminer, Henry V. Secor, Jeffrey I. Seeman
-
Patent number: 5071802Abstract: Carbonaceous materials deposited on solid catalysts and produced, for example, in Beckmann rearrangement in a gaseous phase are burned off by effecting the treatment in the presence of alcohols such as methanol or ethanol together with molecular oxygen-containing gas in order to regenerate the catalyst activity.Type: GrantFiled: March 7, 1990Date of Patent: December 10, 1991Assignee: Sumitomo Chemical Co., Ltd.Inventors: Shinkichi Shimizu, Takayasu Niwa, Nobuyuki Abe, Masanori Doba, Akira Iguchi, Hiroshi Ichihashi, Masaru Kitamura
-
Patent number: 5057518Abstract: The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.Type: GrantFiled: May 24, 1990Date of Patent: October 15, 1991Assignee: Medice Hem.-Pharm. Fabrik Putter GmbH & Co. KGInventor: Henrich H. Paradies
-
Patent number: 5047171Abstract: A liquid crystal compound suitable as a material for ferroelectric liquid crystal display elements and a liquid crystal composition containing the same are provided, which liquid crystal compound is an optically active-2,5-diphenylpyridine expressed by the formula (I) ##STR1## wherein one of R.sup.1 and R.sup.2 is 1-20C alkenyl, alkynyl, alkoxy, alkenyloxy or alkynyloxy and the other is an optically active group; and X and Y each independently represent H, halogen or CN and at least one of X and Y is H.Type: GrantFiled: September 1, 1988Date of Patent: September 10, 1991Assignee: Chisso CorporationInventors: Kouji Ohno, Shinichi Saito, Hiromichi Inoue
-
Patent number: 4970307Abstract: A process for formation of a base from a base precursor, which comprises decomposing the base precursor in the presence of a catalyst. The base precursor has the following formula (I) or (II):(R.sup.1 --C.tbd.C--CO.sub.2 H).sub.x .multidot.B (I)R.sup.2 (--C.tbd.C--CO.sub.2 H).sub.2 .multidot.B.sub.y (II)wherein R.sup.1 is a monovalent group selected from the group consisting of hydrogen, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aryl group, a heterocyclic group, an aralkyl group, an acyl group, an alkoxycarbonyl group, carbamoyl, --CO.sub.2 M (M is an alkali metal) and --CO.sub.2 H.B, each of which may have one or more substituent groups; R.sup.Type: GrantFiled: August 13, 1987Date of Patent: November 13, 1990Assignee: Fuji Photo Film Co., Ltd.Inventors: Keiji Takeda, Jiro Tsukahara, Kozo Sato
-
Patent number: 4965357Abstract: The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10.sup.-5 -10.sup.-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components have pharmacological activities and can act as antimetabolites.Type: GrantFiled: August 6, 1987Date of Patent: October 23, 1990Assignee: Medice Chem.-Pharm. Fabrik Putter GmbH & Co. KGInventor: Henrich H. Paradies
-
Patent number: 4960934Abstract: The reaction of aqueous hydrogen peroxide with tert-amines to yield tert-amine oxides is catalyzed by the addition of a promoter amount of ammonium carbonate, ammonium bicarbonate or ammonium carbamate or mixtures thereof.Type: GrantFiled: October 27, 1989Date of Patent: October 2, 1990Assignee: Ethyl CorporationInventors: Kim R. Smith, Joe D. Sauer
-
Patent number: 4950671Abstract: A heterocyclic compound having the structural formula ##STR1## where R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.6 cycloalkyl, trifluoromethyl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, benzyl or substituted benzyl; and R.sup.1 is at least a partially saturated monocyclic or bicyclic heterocycle of nitrogen which may be substituted with lower alkyl and physiologically acceptable salts thereof is disclosed. A process for forming this compound which involves the reaction of an amine of the formula HR.sup.1 where R.sup.1 has the meanings given above with a substituted 2-propenyl halide having the structural formula ##STR2## where R has the meanings given above; and X is a halogen atom is described. The invention embodies the above-mentioned novel 2-propenyl halide utilized as an intermediate in the formation of the heterocyclic compound of this invention.Type: GrantFiled: March 9, 1989Date of Patent: August 21, 1990Assignees: Uniroyal Chemical Company, Inc., Uniroyal Chemical Ltd/LteeInventors: Hoi Kiong Lai, Robert A. Davis
-
Patent number: 4929733Abstract: N-heterocycles of the general formulae (I) and (II) ##STR1## where R.sup.1 and R.sup.4 to R.sup.9 are each hydrogen, alkyl, aryl, aralkyl, alkylaryl or cycloalkyl and R.sup.2 and R.sup.3 are each an alkyl, alkylaryl, substituted alkyl or cycloalkyl group, are prepared by a process in which an olefin of the formula (III) or (IV) ##STR2## where R.sup.2 to R.sup.9 have the above meanings, is reacted with NH.sub.3 or with a primary amine of the formula H.sub.2 NR.sup.1, where R.sup.1 has the above meanings, in the presence of a zeolite as a catalyst.Type: GrantFiled: June 17, 1988Date of Patent: May 29, 1990Assignee: BASF AktiengesellschaftInventors: Michael Hesse, Wolfgang Hoelderich, Matthias Schwarzmann
-
Patent number: 4895992Abstract: A process for iodinating aromatic compounds by reacting an aromatic compound with oxygen at low temperatures in the presence of a non-acid catalyst containing an oxidation catalyst. The catalyst may be regenerated by heating the catalyst in the presence of oxygen.Type: GrantFiled: September 19, 1988Date of Patent: January 23, 1990Assignee: Eastman Kodak CompanyInventors: Mark Rule, Gerald C. Tustin, Donald L. Carver, Jerry S. Fauver
-
Patent number: 4889865Abstract: Mono, di and tri-esters of 1,8-dihydroxy-10-phenyl-9-anthrone or -9-anthranol have the formula ##STR1## wherein p is 0 or 1,(a) when p=0, t=1 and R.sub.2 represents hydrogen or --COR.sub.3,(b) when p=1, t=0 and R.sub.1 and R.sub.2 each independently represent hydrogen or --COR.sub.3,R.sub.3 represents linear or branched alkyl having 1-17 carbon atoms, cycloalkyl, phenyl or phenyl substituted by lower alkyl, lower alkoxy, halogen, a nitro function, --CF.sub.3 or a hydroxyl function, and mixtures of said esters. These esters are prepared by reacting 1,8-dihydroxy-10-phenyl-9-anthrone with an activated form of an acid. The esters are useful in human or veterinary medicine and in cosmetic compositions.Type: GrantFiled: February 21, 1989Date of Patent: December 26, 1989Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Gerard Lang, Jean Maignan, Serge Restle, Christopher Hensby, Michel Colin