Chalcogen Attached Directly To The Polycyclo Ring System By Nonionic Bonding Patents (Class 548/259)
  • Publication number: 20100204280
    Abstract: A compound of Formula, (I) or Formula: (II)
    Type: Application
    Filed: May 29, 2008
    Publication date: August 12, 2010
    Applicant: UNIVERSITE DE MONTREAL
    Inventors: Christophe Pardin, Jeffrey W. Keillor, William D. Lubell
  • Publication number: 20100197806
    Abstract: The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups; and (ii) reacting the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups with a water-soluble and non-peptidic polymer having three or more primary amino groups under conditions effective to form a cross-linked polymer composition.
    Type: Application
    Filed: April 8, 2010
    Publication date: August 5, 2010
    Applicant: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 7750028
    Abstract: The invention relates to the novel modifications B and C of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide of the formula its use and pharmaceutical preparations comprising this crystal modifications.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: July 6, 2010
    Assignee: Novartis AG
    Inventors: Robert Portmann, Urs C Hofmeier, Andreas Burkhard, Walter Scherrer, Martin Szelagiewicz
  • Publication number: 20100168188
    Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.
    Type: Application
    Filed: September 29, 2006
    Publication date: July 1, 2010
    Inventors: Mark L. Greenlee, Dongfang Meng, Dann L. Parker, JR., Wanying Sun, Kenneth J. Wildonger, Robert R. Wilkening
  • Publication number: 20100163813
    Abstract: The instant invention relates to novel benzotriazole UV-absorbers having a long wavelength shifted absorption spectrum with significant absorbance up to 410-420 nm. Further aspects of the invention are a process for their preparation, a UV stabilized composition containing the new UV-absorbers and the use of the new compounds as UV-light stabilizers for organic materials.
    Type: Application
    Filed: June 18, 2007
    Publication date: July 1, 2010
    Inventors: Katharina Fritzsche, Markus Grob, Adalbert Braig, Iloan Marion Kienzle, GĂ©rard Daniel Georges Vilain
  • Publication number: 20100137280
    Abstract: The present invention relates to compounds of formula (I) wherein A is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-hydroxyalkyl, C2-C6-alkenyl, C2-C6-halo-alkenyl, C3-C6-cycloalkyl, aryl-C1-C4-alkyl, aryl-C2-C4-alkenyl, aryl or hetaryl, is a single or double bond; X1 and X2 are N, CRx1, NRx2, or CRx3Rx4; Rx1, Rx3 and Rx4 are H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylcarbonyl, etc. or two geminal radicals Rx3 and Rx4 together with the carbon atom to which they are bound may form a carbonyl group or a 3- to 6-membered carbocyclic or heterocyclic spiro-annulated ring; Rx2 is hydrogen, C1-C6-alkyl, C1-C6-alkylcarbonyl, C1-C6-haloalkyl, etc.; or two vicinal radicals Rx1, Rx2, Rx3 or Rx4 together with X1 and X2 form a five- or six-membered carbocyclic or heterocyclic fused ring; Y1, Y2 and Y3 are N or CRy; Ry is H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylcarbonyl, C1-C6-haloalkyl, etc.
    Type: Application
    Filed: March 20, 2008
    Publication date: June 3, 2010
    Applicant: ABBOTT GMBH & CO. KG
    Inventors: Thomas Schultz, SR., Wilfried Braje, Sean Colm Turner, Andreas Haupt, Udo Lange, Karla Drescher, Karsten Wicke, Liliane Unger, Mario Mezler, Matthias Mayrer
  • Publication number: 20100113641
    Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 6, 2010
    Applicant: Alcon, Inc.
    Inventor: Walter R. Laredo
  • Patent number: 7695643
    Abstract: The invention relates to novel benzotriazole UV-absorbers having a long wavelength shifted absorption spectrum with significant absorbance up to 410-420 nm. Further aspects of the invention are a process for their preparation, a UV stabilized composition containing the new UV-absorbers and the use of the new compounds as UV-light stabilizers for organic materials.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: April 13, 2010
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Katharina Fritzsche, Adalbert Braig, Markus Frey, Walter Fischer
  • Patent number: 7655805
    Abstract: A method for synthesizing benzotriazole comprises acts of: preparing a first solvent comprising 2-(2-hydroxy-5-methylphenyl) benzotriazole, a basic agent and molecular sieves and a second solvent comprising 3-chloro-2-alkyl propylene; mixing the solvents; and heating the solvents. This method requires only one reaction vessel and produces few by-products, therefore is simpler and cheaper to produce. Furthermore, the molecular sieves are cheaper than catalysts in conventional reactions and may be recycled, giving even greater economic benefits.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: February 2, 2010
    Assignee: UFC Corporation
    Inventors: Ling Lu, Po-Hsuan Wei, Chung-Ning Fan, Yu-Cheng Lee, Hui-Ling Yang, Yu-Chin Lee
  • Patent number: 7652043
    Abstract: Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states in cells having Wnt receptors.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: January 26, 2010
    Assignee: The Johns Hopkins University
    Inventors: Philip A. Beachy, James K. Chen, Ronald K. Mann
  • Publication number: 20100004428
    Abstract: The invention provides methods for preparing polymers bearing a terminal propionic acid. The method involves first reacting a water soluble and non-peptidic polymer comprising at least one hydroxyl group with a tertiary alkyl acrylate in the presence of a catalyst to form a propionic acid ester of the polymer, wherein the polymer has a weight average molecular weight of at least about 10,000 Da; and then treating the propionic acid ester of the polymer with a strong acid to form a propionic acid of the polymer.
    Type: Application
    Filed: September 15, 2009
    Publication date: January 7, 2010
    Applicant: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus
  • Publication number: 20090215910
    Abstract: The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotriazolylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid, such as lysine, to form an amino acid derivative.
    Type: Application
    Filed: April 30, 2009
    Publication date: August 27, 2009
    Applicant: Nektar Therapeutics AL, Corporation
    Inventor: Antoni Kozlowski
  • Patent number: 7511152
    Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: March 31, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Mark L. Greenlee, Dongfang Meng, Donald M. Sperbeck, Kenneth J. Wildonger
  • Patent number: 7507776
    Abstract: Plastic articles can be coated with polymerizable compositions containing a vinyl-functional crosslinkable film former, a large amount of benzotriazole and a copolymerizable monomer that solubilizes the benzotriazole. The cured compositions help protect the article from UV exposure and other weathering effects.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: March 24, 2009
    Assignee: 3M Innovative Properties Company
    Inventors: Steven J. McMan, Stephen A. Johnson, Clinton L. Jones, Eric W. Nelson, Emily S. Goenner
  • Patent number: 7464965
    Abstract: The present invention relates to a water-based fluorescent ink for the purpose of measurement or judgment of the fluorescence emission in a visible light region by an excitation wavelength in a predetermined ultraviolet range, containing water, a coloring material dissolved or dispersed in water, and an organic solvent, having a plurality of fluorescent groups in the coloring material structure of the coloring material, and using a water-soluble coloring material having a sulfonic acid group as the water-soluble group in the state of a free acid, capable of improving the water resistance and the light resistance, dramatically increasing the content of the fluorescent coloring material in the ink, which has conventionally been included only by a small amount in the ink due to the concentration quenching problem, obtaining preferable fluorescence emission and water resistance of the recorded image, and providing preferable adhesion resistance to the recording medium of the coloring material and reliability.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: December 16, 2008
    Assignee: Canon Kabushiki Kaisha
    Inventors: Masako Udagawa, Shoji Koike, Makoto Aoki, Akira Nagashima, Shinichi Hakamada
  • Publication number: 20080157025
    Abstract: The invention relates to novel benzotriazole UV-absorbers having a long wavelength shifted absorption spectrum with significant absorbance up to 410-420 nm. Further aspects of the invention are a process for their preparation, a UV stabilized composition containing the new UV-absorbers and the use of the new compounds as UV-light stabilizers for organic materials.
    Type: Application
    Filed: January 23, 2006
    Publication date: July 3, 2008
    Inventors: Katharina Fritzsche, Adalbert Braig, Markus Frey, Walter Fischer
  • Patent number: 7381762
    Abstract: Hydroxybenzotriazole-based compounds are useful for ultraviolet light absorbing additives for a variety of applications. Such compounds have particular usefulness in various applications, including plastics, automotive, coatings, and food packaging applications. Such inventive compound exhibit excellent UV radiation absorbing activity, high thermal stability, excellent low fogging, low extraction/low migration rates, and high lightfastness levels, particularly when incorporated within certain media and/or on the surface of certain substrates, particularly polyesters, polyolefins, and polyurethanes. Block copolymer chain or chains consisting of poly(oxyalkylene) and/or aliphatic polyester segments can be conveniently tailored to increase the solubility or compatibility in different solvents or resins thereby permitting the introduction of such excellent UV absorbing chromophores within diverse media and/or or diverse substrates.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: June 3, 2008
    Assignee: Milliken & Company
    Inventor: Jusong Xia
  • Patent number: 7326744
    Abstract: The present invention relates to a low dusting crystalline 2,2?-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] type I crystal transformation which exhibits diffraction peaks at diffraction angles (2?±0.1°) of 7.1°, 8.6°, 14.3°, 16.1°, 18.1° and 23.0° in powder X-ray diffraction analysis with Cu-K? radiation; a low dusting 2,2?-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol] type II crystal transformation which does not exhibit a distinct diffraction peak but an amorphous halo in powder X-ray diffraction analysis with Cu-K? radiation; a mixture thereof; a method for preparing them; and a UV light absorber, an emulsion composition and a polymer material using them.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: February 5, 2008
    Assignee: Chempiro Kaei Kaisha, Limited
    Inventors: Naohiko Fukuoka, Yoshinori Ohmae, Yuichi Kaneko, Masayuki Nishimatsu
  • Patent number: 7282590
    Abstract: A compound having the formula Y-A-Z, wherein: A is a 5, 6, or 7 member ring that is monocyclic or is fused to 1 to 3 additional 4 to 8 member rings; wherein ring A and, independently, the fused additional rings are carbocyclic or heterocyclic, and saturated or unsaturated, wherein unsaturated rings are aromatic or non-aromatic; wherein Y and Z are substituents at adjacent positions on ring A; Y represents: Z represents: X and E represent O, S, or NRa or NRb; each of a, b, c, d, e and f independently represents 0 or 1; a+c equals 0, 1, or 2; b+d equals 0, 1, or 2; a+b+c+d+e+f equals 1, 2, or 3; provided that when f is 1, then d is 1, and when d is 0, then f is 0; and when both e and b are 0, then neither R1 nor R2 is chloro or bromo; v represents 0 or 1, provided that when v is 0, then J is hydrogen, a metal ion, or a quaternary ammonium ion; and X is O and G is H; either G is hydrogen, a metal ion, a quaternary ammonium ion, lower alkyl, or comprised of a pharmaceutically active chemica
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: October 16, 2007
    Assignee: The Research Foundation of State University of New York
    Inventor: Iwao Ojima
  • Patent number: 7157586
    Abstract: Benzotriazole UV absorbers substituted with a ultra long ester or amide moiety wherein the ester or amide group is a hydrocarbyl group of 25 to 100 carbon atoms or is a group of alkyl of 25 to 100 carbon atoms interrupted by 5 to 39 oxygen atoms and terminated with an omega-OH or an omega-OR group exhibit excellent stabilization efficacy while they concomitantly do not bloom when incorporated into polyolefin films. These benzotriazole UV absorbers also provide excellent protection to white, dyed, dipped, unscented and/or scented candle wax from discoloration and degradation.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: January 2, 2007
    Assignee: Ciba Specialty Chemcials Corporation
    Inventors: Mervin Wood, Ramanathan Ravichandran, Douglas Wayne Horsey, Anunay Gupta, Deborah DeHessa, Luther A. R. Hall, Andrea Smith, Stephen Mark Andrews
  • Patent number: 7094872
    Abstract: The present invention relates to the preparation of polyethylene glycol carbonate active esters useful for the PEGylation of biological active and pharmaceutically useful peptides and proteins. The invention involves the use of activated carbonate and oxalate esters in the formation of polyethylene glycol mixed carbonate active esters that then react with a linker or directly with a target peptide or protein.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: August 22, 2006
    Assignee: Pharmacia Corporation
    Inventor: Foe S. Tjoeng
  • Patent number: 7084280
    Abstract: The invention relates to benzotriazol-1-yl-aminoacetonitrile compounds and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: August 1, 2006
    Inventors: Pierre Ducray, Thomas Goebel, Noelle Gauvry
  • Patent number: 7078424
    Abstract: This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: July 18, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • Patent number: 6974850
    Abstract: Plastic articles can be coated with polymerizable compositions containing a vinyl-functional crosslinkable film former, a large amount of benzotriazole and a copolymerizable monomer that solubilizes the benzotriazole. The cured compositions help protect the article from UV exposure and other weathering effects.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: December 13, 2005
    Assignee: 3M Innovative Properties Company
    Inventors: Steven J. McMan, Stephen A. Johnson, Clinton L. Jones, Eric W. Nelson, Emily S. Goenner
  • Patent number: 6908936
    Abstract: The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: June 21, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kuo-Long Yu, Rita Lee Civiello, Mark R. Krystal, Kathleen F. Kadow, Nicholas A. Meanwell
  • Patent number: 6841563
    Abstract: Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group. R4 and R5 are independently —H, a C1-C4 straight chained or branched alkyl group or, taken together with the nitrogen atom to which each is bonded, a non-aromatic heterocyclic ring. Ring A and Ring B are independently further substituted with zero, one or two substituents. Physiologically acceptable salts of structural formula shown above are also included. Also disclosed is a method promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal. The method comprises administering to the animal an effective amount of one or more compounds represented by the structural formula as shown or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: January 11, 2005
    Assignee: Eli Lilly and Company
    Inventors: Randall Bruce Hopkins, Deana Lori Hancock, Michael Eugene Quimby
  • Publication number: 20040242735
    Abstract: Plastic articles can be coated with polymerizable compositions containing a vinyl-functional crosslinkable film former, a large amount of benzotriazole and a copolymerizable monomer that solubilizes the benzotriazole. The cured compositions help protect the article from UV exposure and other weathering effects.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 2, 2004
    Inventors: Steven J. McMan, Stephen A. Johnson, Clinton L. Jones, Eric W. Nelson, Emily S. Goenner
  • Patent number: 6800676
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by a phenyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: October 5, 2004
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Stephen D. Pastor, Jacqueline Lau, Michael DiFazio, Joseph Suhadolnik
  • Publication number: 20040131827
    Abstract: A cyanoacrylate adhesive composition having a toughening agent comprising poly(vinylidene-co-acrylonitrile) in combination with fumed silica. A useful amount of poly(vinylidene-co-acrylonitrile) is about 1.0% by weight to about 20.0% by weight fumed silica is usefully present in amounts of 1-10% by wt.
    Type: Application
    Filed: January 6, 2003
    Publication date: July 8, 2004
    Applicant: LOCTITE (R&D) LIMITED
    Inventor: Hanns Roland Misiak
  • Patent number: 6756499
    Abstract: The invention pertains to a process for the preparation of a novel UV absorbing diol of the general formula: wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy; R2 is C1 to C8 linear or branched alkyl.
    Type: Grant
    Filed: December 27, 2000
    Date of Patent: June 29, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Paragkumar Nathalal Thanki, Raj Pal Singh
  • Patent number: 6689771
    Abstract: The present application describes novel amides and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jingwu Duan, Carl P. DeCicco, David J. Nelson, Chu-Biao Xue
  • Patent number: 6653308
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: November 25, 2003
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Patent number: 6653484
    Abstract: Triazine, benzotriazole and benzophenone derivatives which are substituted or bridged with polyoxyalkylene groups, according to claim 1, and their use as UV absorbers, especially in photographic materials, in inks, including inkjet inks and printing inks, in transfer prints, in paints and varnishes, organic polymeric materials, plastics, rubber, glass, packaging materials, in sunscreens of cosmetic preparations and in skin protection compositions.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: November 25, 2003
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Vien Van Toan, Andreas Valet, Pascal Hayoz
  • Patent number: 6610743
    Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: August 26, 2003
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi
  • Patent number: 6605604
    Abstract: The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R1, R2, R3, R4 represent a hydrogen or an alkyl group, or R1 and R3 together form a cycloalkyl group; R5 represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a —CO—R6 group; and R6 represents R7 or OR7 or NR7R8, with R7 representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R8 representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R5 and R6 form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R10 represents a hydrogen atom or a hydroxy group, and in the latter case R1, R2, R
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: August 12, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Patrick Casara, Anne Marie Chollet, Thierry Le Diguarher, Ghanem Atassi, Jacqueline Bonnet, Alain Pierre, Massimo Sabatini, Gordon Tucker, Nicolas Guilbaud
  • Publication number: 20030116059
    Abstract: Lightfast additives for inkjet inks are provided. These additives exhibit excellent lightfastness of many dyestuffs (both water-soluble and water-insoluble). The lightfast additives exhibit good water solubility and significant effect on dye and pigment molecules which fade most when exposed to UV, ambient light, etc., and are suitable for improving permanence of inkjet inks, including thermal inkjet ink, piezo inkjet ink, and the like. The lightfast additive comprises a molecule which is composed of three parts or moieties: A-X—B, where (a) moiety A is an aryl sulfonic acid or aryl carboxylic acid, either in acid form or salt form, with or without substituents (e.g.
    Type: Application
    Filed: November 26, 2002
    Publication date: June 26, 2003
    Inventors: Khe C. Nguyen, Sivapackia Ganapathiappan
  • Patent number: 6559311
    Abstract: The present invention relates to a process for the preparation of a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), and derivatives and intermediates thereof.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: May 6, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Shroj Al Mohitkumar Desai, Raj Pal Singh
  • Publication number: 20030069237
    Abstract: The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Application
    Filed: April 26, 2002
    Publication date: April 10, 2003
    Inventors: John M. Fevig, Joseph Cacciola, Charles G. Clark, Qi Han, Patrick Yuk Sun Lam, Donald J.P. Pinto, James R. Pruitt, Mimi L. Quan, Karen A. Rossi
  • Patent number: 6498176
    Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: December 24, 2002
    Assignee: SmithKlineBeecham Corporation
    Inventors: Karen Elizabeth Lackey, Robert Walton McNutt, Jr.
  • Patent number: 6489486
    Abstract: The present invention relates to a process for the manufacture of compounds of Formula (I): wherein R1 is alkyl; R2, R3, R4, R5 and R6 are, independently, hydrogen, alkyl or alkenyl; X is hydrogen, halogen, alkyl or alkoxy; and the dotted bond is an optional bond. The present invention also relates to novel light screening compositions containing certain of the compounds of Formula (I) and to certain novel compounds of Formula (I), as well as other novel 2-substituted phenyl-benzotriazole compounds.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: December 3, 2002
    Assignee: Roche Vitamins Inc.
    Inventor: Ulrich Huber
  • Patent number: 6469051
    Abstract: A compound represented by the following general formula: wherein R1 and R2 represent amino groups present at adjacent positions each other on the phenyl ring; R3, R4, R5 and R6 independently represent a C1-6 alkyl group; R7, R8, R9 and R10 independently represent a hydrogen atom, a C1-6 alkyl group, an allyl group, or a halogen atom; R11 represents a hydrogen atom or a C1-18 alkyl group; and X− represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: October 22, 2002
    Inventors: Tetsuo Nagano, Hirotatsu Kojima
  • Patent number: 6462060
    Abstract: Compounds with heterocyclic-hydroxyimino-fluorene nuclei that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: October 8, 2002
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Wesley Kwon Mung Chong, Rohit Kumar Duvadie
  • Publication number: 20020143191
    Abstract: Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.
    Type: Application
    Filed: July 16, 2001
    Publication date: October 3, 2002
    Inventors: Gilles Guichard, Marc Rodriguez, Vincent Semetey, Jean-Paul Briand, Marie-Christine Galas-Rodriguez, Pierre Rodriguez, Elisa Rodriguez, Romain Rodriguez
  • Patent number: 6451887
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by &agr;-cumyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: September 17, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Joseph Suhadolnik, Ramanathan Ravichandran, Jacqueline Lau, Carmen Hendricks-Guy, Christophe Bulliard
  • Patent number: 6452018
    Abstract: 2-(2′-hydroxyphenyl)benzotriazoles having general formula (I). The above 2-(2′-hydroyzphenyl)benzotriazoles having general formula (I) are useful as heat, oxygen and light stabilizers for organic polymers. In particular they are useful as UV stabilizers for organic polymers.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: September 17, 2002
    Assignee: Great Lakes Chemical Italia S. r. L.
    Inventors: Rosa Maria Riva, Carlo Neri, Barbara Granelli
  • Patent number: 6409771
    Abstract: The present invention provides a process for removal of excess dye from newly manufactured printed or dyed fabric or yarn, comprising treatment with a rinse liquor comprising at least one enzyme selected from the group consisting of enzymes exhibiting peroxidase activity or laccase activity, an oxidation agent, and at least one mediator comprising N-hydroxyacetanilide.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: June 25, 2002
    Assignee: Novozymes A/S
    Inventors: Ture Damhus, Uwe Vogt, Palle Schneider
  • Patent number: 6403521
    Abstract: A catalyst is for use in a reaction using an oxygen-atom-containing reactant and includes a nitrogen-containing heterocyclic compound of the following formula (1): wherein each of R1 and R2 is, identical to or different from each other, a hydrogen atom, a halogen atom, an alkyl group, a haloalkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, and R1 and R2 may be combined to form a double bond or to form an aromatic or non-aromatic ring with the adjacent two carbon atoms, where one or two of heterocyclic ring containing three nitrogen atoms indicated in the formula may be further formed on the R1 or R2, or on the double bond or aromatic or non-aromatic ring formed by R1 and R2; X is an oxygen atom or a hydroxyl group; and Y is a single bond, a methylene group, or a carbonyl group. This catalyst can introduce an oxygen-atom-containing group into an organic substrate under mild conditions.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: June 11, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano
  • Patent number: 6387992
    Abstract: Compounds of formula I or II where R is a heteroaryl moiety, such as 3-pyridyl, or T is a heteroaryl moiety, such as thien-2,5-diyl, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like, are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a heteroarylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: May 14, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Stephen D. Pastor, Anthony DeBellis, Mervin G. Wood, Joseph Suhadolnik, Deborah DeHessa, Ramanathan Ravichandran
  • Patent number: 6380142
    Abstract: The invention relates to novel storage-stable formulations containing at least one peroxide compound, at least one specific mediator, and at least one pH stabilizer. The invention further relates to the use of such storage-stable formulations as a component in enzymatic two-component bleaching systems.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: April 30, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Vogt, Markus Schindler
  • Patent number: 6380225
    Abstract: Novel benzotriazoles of the formula in which R, X1, X2, X3, X4 and Y have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for the preparation of these substances and their use as microbicides in crop protection and in material protection.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: April 30, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Lutz Assmann, Ralf Tiemann, Martin Kugler, Heinrich Schrage, Klaus Stenzel