Chalcogen Attached Directly To The Polycyclo Ring System By Nonionic Bonding Patents (Class 548/259)
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Patent number: 4948418Abstract: This invention pertains to novel heterocyclic 2,3-dihydrobenzofuran and chromane compounds, including stereoisomers, agriculturally suitable compositions containing them, and their use as broad spectrum herbicides.Type: GrantFiled: August 30, 1989Date of Patent: August 14, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventor: Joseph E. Semple
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Patent number: 4943637Abstract: This invention relates to a method for preparing a 2-phenylbenzotriazole of formula I, ##STR1## (wherein R.sub.1 represents hydrogen or chlorine atom, a lower alkyl group having a carbon number of 1 to 4, a lower alkoxy group having a carbon number of 1 to 4, carboxyl group, or sulfonic acid group; R.sub.2 represents hydrogen or chlorine atom, a lower alkyl group having a carbon number of 1 to 4, or a lower alkoxy group having a carbon number of 1 to 4; R.sub.3 represents hydrogen or chlorine atom, an alkyl group having a carbon number of 1 to 12, a lower alkoxyl group having a carbon number of 1 to 4, phenyl group, a phenyl group substituted with an alkyl group having a carbon number of 1 to 8, phenoxy group, or a phenylalkyl group, the alkyl part of which has a carbon number of 1 to 4; R.sub.4 represents hydrogen or chlorine atom, hydroxyl group, or a lower alkoxy group having a carbon number of 1 to 4; and R.sub.Type: GrantFiled: August 12, 1988Date of Patent: July 24, 1990Assignee: Chemipro Kasei Kaisha, Ltd.Inventors: Shuichi Seino, Tomizo Fujino
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Patent number: 4943574Abstract: (1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.Type: GrantFiled: September 28, 1989Date of Patent: July 24, 1990Assignee: Janssen Pharmaceutica N.V.Inventors: Alfons H. M. Raeymaekers, Eddy J. E. Freyne, Josephu L. H. Van Gelder, Marc G. Venet
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Patent number: 4937348Abstract: A process is provided for preparing 2,2'-methylene-bis-(4-hydrocarbyl-6-benzotriazolyl-phenols) having formula III: ##STR1## wherein: R is selected from the group consisting of alkyl having from one to about twelve carbon atoms; arylalkyl having from seven to about fourteen carbon atoms and cycloalkyl having from three to about twelve carbon atoms;X is selected from the group consisting of hydrogen, halogen, alkyl having from one to about twelve carbon atoms, aryl having from six to ten carbon atoms, arylalkyl having from seven to about sixteen carbon atoms, alkoxy having from one to about twelve carbon atoms, aryloxy having from six to ten carbon atoms; and arylalkoxy having from seven to about sixteen carbon atoms;R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen; alkyl having from one to about six carbon atoms, and R.sub.1 and R.sub.2 taken together to form a four to six member heterocyclic ring including a nitrogen atom; provided, that at least one of R.sub.1 and R.sub.Type: GrantFiled: December 29, 1987Date of Patent: June 26, 1990Assignee: Adeka Argus Chemical Co., Ltd.Inventor: Naohiro Kubota
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Patent number: 4891430Abstract: The invention relates to a new process for preparing active esters or carboyxlic acids, which consists in reacting a carboxylic acid, in the presence of an agent for binding hydrohalic acid, with a carbonate of formula: ##STR1## in which R.sup.1 denotes either a radical of formula ##STR2## in which R.sup.3 and R.sup.4, which may be identical or different, are not hydrogen atoms and denote organic radicals which may be substituted or unsubstituted and saturated or unsaturated, and may or may not be bound to a polymer, and which can be joined together to form a hetero-cyclic system with the nitrogen, atom,or a substituted or unsubstituted aryl radical which may or may not be bound to a polymer,R.sup.2 denotes a hydrogen atom, an aliphatic or cycloaliphatic radical which may be substituted or unsubstituted and saturated or unsaturated, or a substituted or unsubstituted aromatic radical,and X denotes a halogen atom.This process is especially useful for the synthesis of active esters of N-protected amino acids.Type: GrantFiled: September 13, 1988Date of Patent: January 2, 1990Assignee: Societe Internationale Des Poudres et ExplosifsInventors: Gerard Barcelo, Bertrand Castro, Mahmoud Jaouadi, Jean Martinez, Jean-Pierre Senet, Gerard Sennyey
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Patent number: 4891396Abstract: A compound of formula I ##STR1## in which R.sub.1 is selected from C.sub.9-32 alkyl, C.sub.9-32 alkenyl, C.sub.9-32 alkoxy, --CO--R.sub.4 and --(CH.sub.2).sub.1-6 --COOC.sub.6-18 alkyl, where R.sub.4 is C.sub.8-31 alkyl, C.sub.8-31 alkenyl or C.sub.8-31 alkoxy; the alkyl group of each significance of R.sub.1 being uninterrupted or interrupted by one --O--, --S-- --SO.sub.2 -- group and being unsubstituted or substituted by --N(R.sub.5).sub.2, OH or halogen, where each R.sub.5, independently, is selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl and C.sub.1-6 alkoxy;R.sub.2 has a significance of R.sub.1 independently, of R.sub.1 or is --COOH hydrogen, hydroxyC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkoxy, --COOC.sub.1-6 alkyl, OCOC.sub.1-6 alkoxy; Cl, Br, I, OH, C.sub.1-8 alkyl, C.sub.1-8 alkoxy or C.sub.2-8 alkenyl; andR.sub.3 is C.sub.1-6 alkyl, Cl, Br, I, OH, COOH, hydroxyC.sub.1-6 alkyl, C.sub.2-6 alkenyl, hydroxyC.sub.1-6 alkoxy, COOC.sub.1-6 alkyl, --OCOC.sub.1-6 alkoxy or C.sub.Type: GrantFiled: August 26, 1988Date of Patent: January 2, 1990Assignee: Sandoz Ltd.Inventors: Lajos Avar, Helmut Bohnke
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Patent number: 4881967Abstract: This invention pertains to novel heterocyclic 2,3-dihydrobenzofuran and chromane compounds, including stereoisomers, agriculturally suitable composition containing them, and their use as broad spectrum herbicides.Type: GrantFiled: June 2, 1988Date of Patent: November 21, 1989Assignee: E. I. Du Pont De Nemours and CompanyInventor: Joseph E. Semple
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Patent number: 4859726Abstract: Disclosed are bis-benzotriazolylphenol compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 each is a 2-benzotriazolyl radical;R.sup.3 and R.sup.4 each is hydrogen, alkyl, aralkyl, alkoxy, aryl, carboxy, alkoxycarbonyl or halogen; andA is 1,3- or 1,4-phenylene.Also disclosed ae synthetic polymeric materials stabilized with one of the above compounds.Type: GrantFiled: October 24, 1988Date of Patent: August 22, 1989Assignee: Eastman Kodak CompanyInventors: Richard H. S. Wang, Garry L. Myers
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Patent number: 4851542Abstract: N.sub.1 -substituted 1H-benzotriazole hydroxyethyl sulfone compounds, a process for their preparation and their use for the preparation of dyestuffs. Compounds of the general formula ##STR1## in which R is hydrogen or alkyl which has 1 to 6 carbon atoms and can be substituted by hydroxy, sulfo, carboxy, phosphono and/or cyano, W denotes a divalent, optionally substituted aliphatic radical, (C.sub.5 -C.sub.10)-cycloaliphatic radical which is optionally substituted by alkyl, aliphatic-(C.sub.5 -C.sub.8)-cycloaliphatic radical which is optionally substituted by alkyl, optionally substituted araliphatic radical or optionally substituted aromatic carbocyclic radical, it being possible for the aliphatic radicals in W to be interrupted by hetero groups of the formulae --O--, --S--, --SO.sub.Type: GrantFiled: July 23, 1987Date of Patent: July 25, 1989Assignee: Hoechst AktiengesellschaftInventors: Gunther Schwaiger, Hartmut Springer
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Patent number: 4845180Abstract: An ultraviolet absorbing composition comprising a polymer of at least one diisocyantate, at least one polyol and at least one hydroxyl functional, polymerizable ultraviolet absorbing monomer. Included among the preferred ultraviolet absorbing monomers are compounds which have the following structure: ##STR1## and mixtures thereof, wherein X is selected from the group consisting of H, alkoxy radicals and halogen; R.sub.1 is selected from the group consisting of H and alkyl radicals, provided that at least one of X and R.sub.1 is other than H; and R.sub.2 is an organic radical including a functional hydroxyl group.Type: GrantFiled: March 21, 1988Date of Patent: July 4, 1989Assignee: Allergan, Inc.Inventor: Janis C. Henry
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Patent number: 4835167Abstract: The present invention provides new tricyclic benzotriazoles of the general formula: ##STR1## wherein Z is a hydrogen atom or an acyl radical, Y is an oxygen or sulphur atom or two hydrogen atoms and X is an oxygen or sulphur atom or a >CR.sub.1 R.sub.2 or >NR.sub.3 group, R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical, R.sub.2 is a hydrogen atom or an alkyl, alkenyl or cyano group or a carbonyl group substituted by a hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group or R.sub.2, together with R.sub.1, represents a cycloalkylene radical or R.sub.1 and R.sub.2 together form an alkylidene or cycloalkylidene radical and R.sub.3 is a hydrogen atom or an alkyl radical; the tautomers thereof and the physiologically acceptable acid-addition salts thereof with inorganic and organic acids.Type: GrantFiled: August 3, 1987Date of Patent: May 30, 1989Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Von Der Saal, Walter-Gunar Friebe, Alfred Mertens, Bernd Muller-Beckmann, Gisbert Sponer
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Patent number: 4835284Abstract: This invention relates to a method for preparing 2-phenylbenzotriazoles having the formula I, ##STR1##Type: GrantFiled: January 27, 1988Date of Patent: May 30, 1989Assignee: Chemipro Kasei Kaisha, Ltd.Inventor: Shuichi Seino
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Substituted heterocyclic benzamides, methods of preparing them and their application as anti-emetics
Patent number: 4816471Abstract: There are provided substituted heterocyclic benzamides and derivatives thof which exhibit strong anti-emetic properties.Type: GrantFiled: April 30, 1986Date of Patent: March 28, 1989Assignee: Societe d'Etudes Scientifiques et Industrielles de l'Ille-de FranceInventors: Michel Thominet, Jacques Acher, Jean-Claude Monier -
Patent number: 4804765Abstract: The invention concerns a novel process for the synthesis of N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimidobenzamide, which successively comprises the preparation of 2-methoxy-4,5-diaminobenzoic acid, 2-methoxy-4,5-diacetylaminobenzoic acid, N-(2',5'-dihalopentyl)-2-methoxy-4,5-diacetylaminobenzamide, N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-diacetylaminobenzamide and then N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimido benzamide.Type: GrantFiled: December 18, 1985Date of Patent: February 14, 1989Assignee: Societe D'Etudes Scientifiques et Industrielles de L'Ile-d-FranceInventors: Jacques Acher, Jean-Claude Monier
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Patent number: 4788292Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, independently of one another, represent hydrogen, hydroxy or halogen or are alkyl, alkoxy, alkanoyloxy, or alkanoylamino groups which are unsubstituted or substituted by alkoxy, hydroxyl, halogen, aryl, cycloalkyl, azacycloalkyl, cyano or by polyalkyleneoxy, or two or more of adjacent R.sub.1 -R.sub.4 together form one or more fused rings of 5-8 members each; R is alkylene of up to 16 carbon atoms which is unsubstituted or substituted by hydroxy, lower alkoxy, or halo and which may be interrupted by oxygen, sulfur, carboxamido, sulfonamido, aminosulfonyl, aminocarbonyl, carbonyloxy, sulfinyl, or sulfonyl; and R.sub.f is perfluoroalkyl or perfluoroalkoxyalkyl of 4 to 16 carbon atoms; or mixtures thereof. Such compounds are useful as oil soluble corrosion inhibitors.Type: GrantFiled: July 31, 1986Date of Patent: November 29, 1988Assignee: Ciba-Geigy CorporationInventors: Kirtland P. Clark, Athanasios Karydas
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Patent number: 4786728Abstract: Triphendioxazine compounds with properties of fiber-reactive dyestuffs corresponding to the general formula ##STR1## in which T is an optionally substituted alkyl group with 1 to 6 carbon atoms, excluding a radical of the group Y defined below, it also being possible for the alkyl group to be interrupted by hetero atoms, or is an optionally substituted aryl group,B is an oxygen or sulfur atom or an amino group,W is a divalent, optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic-carbocyclic radical or a benzotriazole radical combined with one of these radicals, it being possible for the aliphatic radicals to be interrupted by hetero groups and/or for aliphatic and aryl radicals to be bonded to one another by a hetero group,R is hydrogen, alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 5 carbon atoms, halogen, carboxy or sulfo,X.sup.Type: GrantFiled: September 18, 1986Date of Patent: November 22, 1988Assignee: Hoechst AktiengesellschaftInventors: Gunther Schwaiger, Hartmut Springer, Walter Helmling
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Patent number: 4782164Abstract: The invention relates to a new process for preparing active esters or carboxylic acids, which consists in reacting a carboxylic acid, in the presence of an agent for binding hydrohalic acid, with a carbonate of formula: ##STR1## in which R.sup.1 denotes either a radical of formula ##STR2## in which R.sup.3 and R.sup.4, which may be identical or different, are not hydrogen atoms and denote organic radicals which may be substituted or unsubstituted and saturated or unsaturated, and may be or may not be bound to a polymer, and which can be joined together to form a hetero-cyclic system with the nitrogen atom,or a substituted or unsubstituted aryl radical which may or may not be bound to a polymer,R.sup.2 denotes a hydrogen atom, an aliphatic or cycloaliphatic radical which may be substituted or unsubstituted and saturated or unsaturated, or a substituted or unsubstituted aromatic radical,and X denotes a halogen atom.This process is especially useful for the synthesis of active esters of N-protected amino acids.Type: GrantFiled: November 22, 1985Date of Patent: November 1, 1988Assignee: Societe Nationale des Poudres et ExplosifsInventors: Gerard Barcelo, Bertrand Castro, Mahmoud Jaouadi, Jean Martinez, Jean-Pierre Senet, Gerard Sennyey
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Patent number: 4769383Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are selected from hydrogen, hydroxyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and C.sub.1-4 alkanoyl; G is a hydrogen atom or a hydroxyl group, and m and n are independently integers of from 1 to 3, with the proviso that when G is a hydroxyl grup, m or n is 1;is useful in the treatment of asthma.Type: GrantFiled: September 10, 1986Date of Patent: September 6, 1988Assignee: Beecham Group p.l.c.Inventors: Harry Smith, Derek R. Buckle
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Ultraviolet absorbing polymers comprising 2-(2'-hydroxy-5'-acryloyloxyalkoxyphenyl)-2H-benzotriazole
Patent number: 4716234Abstract: Ultraviolet light absorbing compositions comprising 2-(2'-hydroxy-5'-acryloyloxyalkoxyphenyl(-2H-benzotrizoles, and copolymers thereof with one or more other monomers copolyermizable therewith, particularly acrylic monomers, are useful in the manufacture of ocular devices, particularly intraocular lenses and contact lenses.Type: GrantFiled: December 1, 1986Date of Patent: December 29, 1987Assignee: Iolab CorporationInventors: Gary B. Dunks, Akira Yamada, Charles D. Beard, Namassivaya Doddi -
Patent number: 4692526Abstract: A process for preparing a compound of formula (I) ##STR1## wherein X phenyl optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sup.1 is hydrogen or C.sub.1-6 alkyl; and n is an integer of from 1 to 6; which process comprises, cyclizing a compound of formula (II): ##STR2## wherein X, R.sup.1 and n are as defined in relation to formula (I); Y is an hydroxy or an acid activating group and R.sup.x is hydrogen or an N- protecting group and thereafter if desired carrying out one or more of the following steps: (i) removing any protecting group R.sup.x, (ii) preparing a salt of the compound of formula (I).Type: GrantFiled: November 12, 1985Date of Patent: September 8, 1987Assignee: Beecham Group PLCInventors: Derek R. Buckle, Stephen T. Carpenter
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Patent number: 4681905Abstract: Stabilizer compositions for synthetic resins are provided, improving the resistance of the resin to deterioration when exposed to ultraviolet light, comprising a 2,2,6,6-tetramethylpiperidyl compound and an alkylidene-bis-(benzotriazolyl phenol) having the formula: ##STR1## wherein: R.sub.1 is hydrogen or alkyl having from one to about twelve carbon atoms;R.sub.2 is alkyl having from one to about twelve carbon atoms or arylalkyl having from seven to about sixteen carbon atoms;X is selected from the group consisting of hydrogen, halogen, alkyl having from one to about twelve carbon atoms, aryl having from six to ten carbon atoms, arylalkyl having from seven to about sixteen carbon atoms, alkoxy having from one to about twelve carbon atoms, aryloxy having from six to ten carbon atoms; and arylalkoxy having from seven to about sixteen carbon atoms; as well as synthetic resin compositions containing such stabilizers.Type: GrantFiled: November 6, 1985Date of Patent: July 21, 1987Assignee: Adeka Argus Chemical Co., Ltd.Inventors: Naohiro Kubota, Atsushi Nishimura
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Patent number: 4673686Abstract: There are provided new substituted heterocyclic benzamides and derivatives hereof which provide modifications on the central nervous system.Type: GrantFiled: August 26, 1985Date of Patent: June 16, 1987Assignee: Societe d'Etudes Scientifiques et Industrielle de l'Ile de FranceInventors: Michel Thominet, Jacques Acher, Jean-Claude Monier
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Patent number: 4668278Abstract: A compound of the formula: ##STR1## wherein R is a hydrogen atom, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkenyloxy group, a C.sub.3 -C.sub.4 alkynyloxy group, a C.sub.1 -C.sub.4 alkylthio group, a dichlorocyclopropylmethoxy group or a methyldichlorocyclopropylmethoxy group, X is a chlorine atom or a bromine atom and Y is a hydrogen atom, a fluorine atom or a chlorine atom, which is useful as a herbicide.Type: GrantFiled: October 1, 1984Date of Patent: May 26, 1987Assignee: Sumitomo Chemical Company, LimitedInventors: Toru Haga, Eiki Nagano, Masayuki Takase, Ryo Sato
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Patent number: 4626368Abstract: Benzotriazole or a substituted benzotriazole when reacted with alkyl aldehydes and dialkylhydrogen phosphites provide products which improve the load-carrying, antiwear properties of lubricant oils and greases.Type: GrantFiled: December 10, 1985Date of Patent: December 2, 1986Assignee: Mobil Oil CorporationInventor: Angeline B. Cardis
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Patent number: 4611061Abstract: The compounds 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles are useful as intermediate alcohols in the preparation of corresponding 2'-hydroxy-5'-acrylyloxyphenyl-2H-benzotriazole monomers, which in turn are copolymerizable with ethylenically unsaturated monomers, particularly acrylic monomers, to impart ultraviolet absorbing properties to the resulting copolymers.Type: GrantFiled: March 26, 1984Date of Patent: September 9, 1986Assignee: Iolab CorporationInventors: Charles D. Beard, Namassivaya Doddi, Akira Yamada
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Patent number: 4560688Abstract: Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is substiuted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.Type: GrantFiled: February 8, 1984Date of Patent: December 24, 1985Assignee: Schering CorporationInventor: Frank J. Villani
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Patent number: 4560694Abstract: Alkylene(cycloalkylene)-bis-heterocyclyl-biguanides of the formula ##STR1## in which A and B each independently is a nitrogen-containing heterocyclic radical which is linked via a nitrogen atom,R is an optionally alkyl-substituted cycloalkylene radical, or an alkylene radical which is optionally substituted by cycloalkylene, bicycloalkylene, tricycloalkylene, oxygen, sulphur or the NR.sup.3 group,R.sup.1 and R.sup.2 each independently is hydrogen, alkyl or optionally substituted aralkyl, orR.sup.1 and R.sup.2 together with the two nitrogen atoms on which they are located and R form a heterocyclic ring, andR.sup.3 is hydrogen, alkyl or optionally substituted aralkyl,or salts thereof which possess fungicidal activity.Type: GrantFiled: May 20, 1983Date of Patent: December 24, 1985Assignee: Bayer AktiengesellschaftInventors: Siegfried Oeckl, Hans-Georg Schmitt, Wilhelm Brandes
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Patent number: 4528381Abstract: The invention provides a process for preparing triazoles comprising reacting a compound having the structural formula ##STR1## with a compound having the formulaR--ON.dbd.Oin the presence of C.sub.6 -C.sub.10 alkanol, wherein n is 0, 1 or 2, R is C.sub.6 -C.sub.10 alkyl and R.sup.1 is hydrogen or C.sub.1 -C.sub.10 alkyl.Type: GrantFiled: August 26, 1982Date of Patent: July 9, 1985Assignee: Uniroyal, Inc.Inventors: Richard A. Gencarelli, Edward L. Wheeler
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Patent number: 4528311Abstract: Ultraviolet light absorbing polymer compositions comprising copolymers of 2-Hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles with one or more other monomers copolymerizable therewith, particularly acrylic monomers are useful in the manufacture of occular devices, particularly intraoccular lenses and contact lenses. Polymers of the disclosed benzotriazoles may be added to other organic materials to impart ultraviolet absorbing properties thereo.Type: GrantFiled: July 11, 1983Date of Patent: July 9, 1985Assignee: Iolab CorporationInventors: Charles D. Beard, Akira Yamada, Namassivaya Doddi
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Patent number: 4512795Abstract: Diazatricyclononene compounds of the formula ##STR1## and their intermediates, i.e. norbornane compounds of the formula ##STR2## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, A and n have the meanings given in the claims and in the description, their preparation and their use as plant protection agents or plant growth regulators.Type: GrantFiled: January 11, 1983Date of Patent: April 23, 1985Assignee: BASF AktiengesellschaftInventors: Norbert Rieber, Rolf Platz, Johann Jung
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Patent number: 4508657Abstract: Process for the preparation of peptides including higher polypeptides utilizing indenylmethoxycarbonyl blocking groups and products produced thereby.Type: GrantFiled: April 29, 1983Date of Patent: April 2, 1985Assignee: Research CorporationInventors: Louis A. Carpino, Beri Cohen
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Patent number: 4504628Abstract: An addition polymerizable UV stabilizer is prepared by reacting an isocyanatoalkyl ester of an addition polymerizable carboxylic acid (such as 2-isocyanatoethyl methacrylate) with an UV stabilization functionality bearing an active hydrogen moiety which is reactive with the isocyanate (such as 2-hydroxy-4-(2-hydroxyethoxy)benzophenone).Type: GrantFiled: April 14, 1983Date of Patent: March 12, 1985Assignee: The Dow Chemical CompanyInventor: Mark R. Johnson
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Patent number: 4503063Abstract: Compounds of the formula ##STR1## a pharmaceutically or agriculturally acceptable salt thereof, wherein R is 5-chloro-2-pyridyl or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is CONR.sup.2 R.sup.3 where either(a) R.sup.2 is H or C.sub.1 -C.sub.4 alkyl and R.sup.3 is C.sub.2 -C.sub.4 alkanoyl or optionally substituted benzoyl; or(b) R.sup.2 and R.sup.3 are each (C.sub.1 -C.sub.4 alkoxy)carbonyl; and R.sup.4 and R.sup.5 are each H or CH.sub.3 ; methods for their use in combating fungal infections in plants, seeds and animals, including humans, and pharmaceutical and agricultural compositions containing them.Type: GrantFiled: September 26, 1983Date of Patent: March 5, 1985Assignee: Pfizer Inc.Inventors: Kenneth Richardson, Kelvin Cooper
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Patent number: 4482496Abstract: The invention relates to stilbene compounds of the formula ##STR1## wherein Q is hydrogen; a monocyclic 5- or 6-membered aromatic heterocyclic ring which is unsubstituted or substituted by non-chromophoric groups and which contains no fused benzene rings or one or two fused benzene rings; a bicyclic 9-membered aromatic heterocyclic ring or the radical --CH.dbd.C(R.sub.1)(R.sub.2), in which R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by non-chromophoric groups, and R.sub.2 is alkoxycarbonyl containing altogether 2 to 7 carbons atoms, cyano, carboxyl, carbamoyl, phosphonic acid dialkyl ester, C.sub.1 -C.sub.6 alkyl or arylsulfonyl; or Q may also be ##STR2## R.sub.o is hydrogen or C.sub.1 -C.sub.6 alkyl, R is C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by non-chromophoric groups, C.sub.2 -C.sub.5 alkenyl, C.sub.2 -C.sub.5 alkynyl, di(C.sub.1 -C.sub.4)alkylamino(C.sub.1 -C.sub.4)alkyl, C.sub.1 -C.sub.4 hydroxyalkyl, C.sub.1 -C.sub.Type: GrantFiled: June 1, 1982Date of Patent: November 13, 1984Assignee: Ciba-Geigy CorporationInventor: Kurt Weber
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Patent number: 4474947Abstract: Benzazoles, including benzatriazoles and benzimidazoles are employed in phospate triester oligonucleotide synthesis. The benzazoles form arylbenzazolide coupling agents, and phosphorodibenzazolides. Processes employing these reagents are also disclosed.Type: GrantFiled: April 8, 1982Date of Patent: October 2, 1984Assignee: BiosearchInventors: Derek Hudson, Ronald M. Cook
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Patent number: 4456539Abstract: Oxidation in lubricants is reduced by adding to the lubricant a small portion of a triazole/dithiophosphate reaction product.Type: GrantFiled: July 29, 1982Date of Patent: June 26, 1984Assignee: Mobil Oil CorporationInventor: Joosup Shim
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Patent number: 4452626Abstract: Certain 4-(benzotriazol-1-yl)phenoxy)alkanoic acids, esters and salts, useful as herbicides.Type: GrantFiled: September 20, 1982Date of Patent: June 5, 1984Assignee: Shell Oil CompanyInventors: Kurt H. Pilgram, Richard D. Skiles
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Patent number: 4431589Abstract: These are described compounds of formula (I) ##STR1## or an acid addition salt thereof; in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, halogen, C.sub.1-4 haloalkyl, nitro, C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylthio or phenylsulphonyl; in which R.sup.5 is a group of the formula ##STR2## where R.sup.7 is hydrogen or C.sub.1-6 alkyl, R.sup.8 is hydrogen or C.sub.1-4 alkyl and n is 0 or 1, provided that when R.sup.7 is hydrogen n is 0; and in which R.sup.6 is attached to the 1, 2 or 3 position of the triazole ring and is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, phenyl, benzyl or acyl. These compounds are pharmaceutically active and are especially useful in the treatment of disorders of the central nervous system. They are prepared by reacting an amine of formula R.sup.Type: GrantFiled: December 3, 1981Date of Patent: February 14, 1984Assignee: Lilly HouseInventors: Jiban K. Chakrabarti, Terrence M. Hotten, David J. Steggles
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Patent number: 4424361Abstract: Process for the preparation of compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 which may be the same or different, represent hydrogen, halogen, nitro, lower alkyl or lower alkoxy, where lower means of up to six carbon atoms, or any adjacent two of R.sub.1 to R.sub.4 taken together represent an alkylene group containing from 3 to 5 carbon atoms or a 1,4-buta-1,3-dienylene group, by removal of CH.sub.2 R.sub.5 wherein R.sub.5 is phenyl optionally substituted with one or two groups selected from C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or nitro from a compound of formula (II): ##STR2## with an alkali metal C.sub.1-4 primary alkoxide. The compounds are used to inhibit allergic responses.Type: GrantFiled: January 14, 1981Date of Patent: January 3, 1984Assignee: Beecham Group LimitedInventor: John M. Tedder
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Patent number: 4414393Abstract: Ultraviolet-absorbing stabilizers of the formula E-(G-R).sub.n, L-(G-E).sub.m, or [G-E.sub.1 -G-Q].sub.p where E is a radical derived from an oxanilide, benzalmalonate, .alpha.-cyanocinnamate or o-hydroxyphenylbenzotriazole, E.sub.1 is a radical derived from an oxanilide, G is --OCH.sub.2 CHOH--, R is alkyl, phenyl or --CH.sub.2 OT where T is alkyl or alkenyl, n is 1 or 2, m is 2 or 3, L is a direct bond, alkylene or other bis or tris radical, Q has the same meaning as L when m is 2, and p is 1 to 4, are particularly resistant to loss during weathering of outdoor thermoset or thermoplastic coating systems while exhibiting good stabilization efficacy and compatibility in said systems.Type: GrantFiled: November 5, 1981Date of Patent: November 8, 1983Assignee: Ciba-Geigy CorporationInventors: Martin Dexter, Roland A. E. Winter
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Patent number: 4405620Abstract: Compounds of the formula (I), or pharmaceutically acceptable salts thereof ##STR1## wherein X is phenyl, optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6, pharmaceutical compositions containing them and a process for their preparation. These compounds are useful in the prophylaxis or treatment of diseases due to a histamine-mediated allergic response.Type: GrantFiled: January 19, 1981Date of Patent: September 20, 1983Assignee: Beecham Group LimitedInventors: Derek R. Buckle, Harry Smith
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Patent number: 4398028Abstract: The present invention concerns compounds of formula ##STR1## wherein X is O, S or NH; n is 1 or 2 and A is a 5-membered heterocyclic ring, wherein the bicyclic system may be substituted. The compounds are useful as myotonolytic and anti-hypertensive agents.Type: GrantFiled: June 24, 1981Date of Patent: August 9, 1983Assignee: Sandoz Ltd.Inventor: Peter Neumann
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Patent number: 4387100Abstract: Phenoxy-aminopropanol derivatives of the formula ##STR1## wherein R is lower alkyl, X is oxygen or sulfur, n is the integer zero or 1, Y is methylene, ethylene or propylene or, when n is zero, Y can also be a group of the formula--CH.dbd.CH--C*H.sub.2 -- (a), wherein the double-bond is trans and the carbon atom marked with an asterisk is linked to Z, and Z is a 5-membered aromatic heterocyclic ring which contains one or more nitrogen atoms as the sole hetero atom (s), said heterocyclic ring is linked to Y via a nitrogen atom, and may be substituted by halogen, lower alkyl, lower alkoxy, aryl, cyano or carboxamido, or on adjacent carbon atoms by a group of the formula ##STR2## and pharmaceutically acceptable acid addition salts thereof are described. A process for the preparation of the compound of formula I and pharmaceutical preparations containing them are also described. The aforementioned compounds and salts possess .beta.-adrenergic blocking activity and antihypertensive activity.Type: GrantFiled: February 24, 1981Date of Patent: June 7, 1983Assignee: Hoffmann-La Roche Inc.Inventor: Peter J. Machin
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Patent number: 4378360Abstract: Compounds of formula (I): ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6 and pharmaceutically acceptable salts thereof; pharmaceutical compositions containing them; a process for their preparation; and their use in treating allergy.Type: GrantFiled: April 15, 1981Date of Patent: March 29, 1983Assignee: Beecham Group LimitedInventors: Derek R. Buckle, Harry Smith, John M. Tedder
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Patent number: 4378361Abstract: Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof.Type: GrantFiled: July 22, 1981Date of Patent: March 29, 1983Assignee: Boehringer Ingelheim KGInventors: Kurt Schromm, Anton Mentrup, Ernst-Otto Renth, Armin Fugner, Ilse Streller
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Patent number: 4359469Abstract: N-Sulphenylated oxime-carbamates of the formula ##STR1## in which R is alkyl or optionally substituted cycloalkyl, aryl or aralkyl,R.sup.1 is an optionally substituted N-containing heterocyclic radical or an alkyl or cycloalkyl radical substituted by an optionally substituted N-containing heterocyclic radical,R.sup.2 is alkyl,R.sup.3 is alkyl, halogenoalkyl, optionally substituted phenyl or alkoxycarbonyl, a radical identical to that to which the --(S).sub.n --R.sup.3 group is bonded, or ##STR2## R.sup.4 is alkyl, dialkylamino or optionally substituted phenyl, R.sup.5 is alkyl, andn is 1 or 2,and their salts, which possess arthropodicidal, nematicidal and fungicidal properties.Type: GrantFiled: July 25, 1977Date of Patent: November 16, 1982Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Bernhard Homeyer, Ingeborg Hammann
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Patent number: 4353915Abstract: 2-(Azol-1-yl)-aldoxime-carbamates of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently is alkyl or together form an alkylene bridge,R.sup.3 is hydrogen or alkyl,R.sup.4 is hydrogen, alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, alkoxyalkyl or alkylthioalkyl, andAz is azolyl,which possess arthropodicidal and nematicidal properties.Type: GrantFiled: January 12, 1978Date of Patent: October 12, 1982Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Bernhard Homeyer, Ingeborg Hammann
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Patent number: 4346093Abstract: The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl, hydroxyalkyl, alkoxycarbonyl or alkanoyloxyalkyl radicals or together represent an alkylene radical, R.sub.4 is a hydrogen atom or a lower alkanoyl radical or an aroyl radical, R.sub.5 is a hydrogen atom or a lower alkyl radical or an aralkyl radical, R.sub.6 is a hydrogen atom or a lower alkyl radical, R.sub.7 is a hydrogen atom, a hydroxyl group or a lower alkyl radical, Z is a valency bond, a methylene radical or an oxygen or sulphur atom, Ar is a carbocyclic aryl radical or a pyridyl radical, R.sub.8, R.sub.9 and R.sub.Type: GrantFiled: January 31, 1980Date of Patent: August 24, 1982Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Helmut Michel, Carl H. Ross, Fritz Wiedemann, Wolfgang Bartsch, Karl Dietmann
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Patent number: 4323633Abstract: It is desirable to protect color photographic dye images from ultraviolet radiation which tends to cause dyes to fade.It has been the practice in the art to add materials into or above the silver halide emulsions which will absorb ultraviolet radiation but allow transmission of visible radiation.One of the best classes of compounds are the 2-(2'-hydroxyphenyl)-benzotriazoles. These materials absorb ultraviolet radiation well, but tend to have poor solubility, crystallize out of the coating solution and emulsion, and diffuse through the photographic element.A novel class of substituted 2-(2'-hydroxyphenyl)-benzotriazoles has been found to reduce many of these problems.Type: GrantFiled: November 13, 1980Date of Patent: April 6, 1982Assignee: Minnesota Mining and Manufacturing CompanyInventor: Paolo Beretta
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Patent number: 4319028Abstract: Cephalosporin antibiotics of the formula ##STR1## wherein R is cyclohexadienyl, phenyl or substituted phenyl, 2-thienyl, 3-thienyl, 2-furyl or 3-furyl; R.sub.1 is a substituted phenyl having 1 to 4 hydroxy substituents or 1 to 3 amino substituents; and wherein Q is halo, methoxy, methyl or a group of the formula --CH.sub.2 R.sub.2 wherein R.sub.2 is alkanoyloxy, carbamoyloxy, alkoxy, halo, pyridinium or substituted pyridinium or a group of the formula --SR.sub.3 wherein R.sub.3 is alkyl, phenyl, substituted phenyl or a 5 or 6 membered-heteroaryl group having from 1 to 4 heteroatoms selected from the group consisting of O, S, and N;are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.Type: GrantFiled: August 26, 1976Date of Patent: March 9, 1982Assignee: Eli Lilly and CompanyInventors: David K. Herron, William H. W. Lunn