Chalcogen Attached Directly To The Polycyclo Ring System By Nonionic Bonding Patents (Class 548/259)
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Patent number: 6350747Abstract: The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways in general, and in particular in the pathological processes which involve aberrant cellular proliferation, such as tumor growth. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful in inhibiting tumor growth via inhibition of tumor-related angiogenesis.Type: GrantFiled: February 28, 2000Date of Patent: February 26, 2002Assignee: Glaxo Wellcome Inc.Inventors: Kimberley Caroline Glennon, Lee Frederick Kuyper, Karen Elizabeth Lackey, Robert Walton Mcnutt, Jr.
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Patent number: 6337402Abstract: Asymmetrical bisbenzotriazoles of the formula I where G2′ is perfluoroalkyl of 1 to 12 carbon atoms, preferably CF3, and where G2 does not contain said group are red-shifted and due to the asymmetry are particularly soluble and useful in a host of applications including automotive coatings, thermoplastics and especially in adhesive compositions, themselves useful in solar panels and other laminate structures.Type: GrantFiled: January 22, 2001Date of Patent: January 8, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin Wood, Jacqueline Lau, Ramanathan Ravichandran
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Patent number: 6329445Abstract: An ocular lens material comprising a polymer prepared by polymerizing a component containing a benzotriazole compound (A) represented by the formula (I): wherein X is hydrogen, a halogen, an alkyl having 1 to 3 carbons or an alkoxy having 1 to 3 carbons, R1 is an alkylene having 2 to 10 carbons, R2 is hydrogen, methyl or a halogenated methyl, R3 is hydrogen, an alkyl or an aryl, and each of R4 and R5 is independently an alkyl having 1 to 8 carbons. The material shows excellent ultraviolet-ray absorbing power and oxidation inhibiting power at the same time.Type: GrantFiled: February 29, 2000Date of Patent: December 11, 2001Assignee: Menicon Co., LTDInventors: Akiko Okumura, Kazuhiko Nakada, Akinori Okumura
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Patent number: 6320056Abstract: The invention also pertains to a process for their preparation of bromo functionalised benzotriazole UV absorber of the general formula 1 wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy by reacting a benzotriazole having formula 2 wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy with bromine in the presence of a free radical initiator in a non-polar solvent to produce a bromo functionialized benzotriazole.Type: GrantFiled: December 27, 2000Date of Patent: November 20, 2001Assignee: Council of Scientific and Industrial ResearchInventors: Paragkumar Nathalal Thanki, Raj Pal Singh
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Patent number: 6307055Abstract: The invention pertains to novel UV absorbing diol of the general formula: wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy; R2 is C1 to C8 linear or branched alkyl, and to a process for the preparation thereof.Type: GrantFiled: December 27, 2000Date of Patent: October 23, 2001Assignee: Council of Scientific and Industrial ResearchInventors: Paragkumar Nathalal Thanki, Raj Pal Singh
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Patent number: 6284895Abstract: The invention pertains to bromo functionalized benzotriazole UV absorber of the general formula 1 wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halogen, tert-butyl and C1 to C12 alkoxy.Type: GrantFiled: December 27, 2000Date of Patent: September 4, 2001Assignee: Council of Scientific and Industrial ResearchInventors: Paragkumar Nathalal Thanki, Raj Pal Singh
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Patent number: 6281313Abstract: The present invention provides a 2,2′-bis(6-benzotriazolylphenol) compound represented by the formula wherein A represents a methylene group or the like, R1 and R5 each represent a hydrogen atom, an alkyl group or the like, R2 represents a hydrogen atom or the like, R3 represents an alkylene group or the like, and R4 represents a hydrogen atom or a methyl group. The compound of the invention is useful as an UV absorber. Further, the compound of the invention can be incorporated into a copolymer by copolymerization with a vinyl monomer, and a polymer composition containing the copolymer can be used as an UV absorber.Type: GrantFiled: May 11, 2000Date of Patent: August 28, 2001Assignee: Otsuka Chemical Co., Ltd.Inventors: Shinji Nakano, Emiko Daimon, Minoru Yamamoto, Mitsuo Akada
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Patent number: 6261676Abstract: An ultraviolet light absorbing material that resists blooming and migration is made up of a fluoropolymer and an amide functional ultraviolet light absorbing compound, wherein the polymer and the amide functional ultraviolet light absorbing compound are hydrogen bonded to one another. Polymeric films that contain a polymeric matrix and the ultraviolet light absorbing material are useful as the top layer in multilayer constructions such as retroreflective sheetings and conformable marking sheets.Type: GrantFiled: August 3, 1999Date of Patent: July 17, 2001Assignee: 3M Innovative Properties CompanyInventors: David B. Olson, David M. Burns, Bruce B. Wilson
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Patent number: 6248134Abstract: The present invention provides a process for removal of excess dye from newly manufactured printed or dyed fabric or yarn, comprising treatment with a rinse liquor comprising at least one enzyme selected from the group consisting of enzymes exhibiting peroxidase activity or laccase activity, an oxidation agent, and at least one mediator selected from the group consisting of aliphatic, cyclo-aliphatic, heterocyclic or aromatic compounds containing the moiety >N—OH, in particular 1-hydroxybenzotriazole.Type: GrantFiled: February 8, 2000Date of Patent: June 19, 2001Assignees: Novozymes A/S, Bayer AGInventors: Ture Damhus, Uwe Vogt
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Patent number: 6245915Abstract: Asymmetrical bis benzotriazoles of the formula I where G2′ is perfluoroalkyl of 1 to 12 carbon atoms, preferably CF3, and where G2 does not contain said group are red-shifted and due to the asymmetry are particularly soluble and useful in a host of applications including automotive coatings, thermoplastics and especially in adhesive compositions, themselves useful in solar panels and other laminate structures.Type: GrantFiled: April 17, 2000Date of Patent: June 12, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin Wood, Jacqueline Lau, Ramanathan Ravichandran
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Patent number: 6204380Abstract: Carboxylic acid ester derivatives of formula (1): wherein R is C1-C6 alkyl, R2 and R3 are independently hydrogen or C1-C3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): wherein R3 and Q are as defined above, with malonic acid monoester derivatives of formula (6): wherein R and R2 are as defined above, in the presence of a base.Type: GrantFiled: April 21, 1999Date of Patent: March 20, 2001Assignee: Sumitomo Chemical Company, LimitedInventor: Takashi Furukawa
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Patent number: 6187845Abstract: Adhesive compositions are rendered stable against degradation caused by ultraviolet light through the incorporation of selected highly soluble, red-shifted, photostable benzotriazole UV absorbers which absorb light strongly in the 350 to 400 nm range. These UV absorbers exhibit excellent photostability and are highly soluble in adhesive formulations. The laminated articles derived from these compositions include, for example, solar control films, films and glazings, UV absorbing glasses and glass coatings, windscreens, retroreflective sheetings and signs, solar reflectors, optical films and the like.Type: GrantFiled: May 3, 1999Date of Patent: February 13, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Walter Renz, Mervin Gale Wood, Jr., Joseph Suhadolnik, Ramanathan Ravichandran, Revathi Iyengar
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Patent number: 6172092Abstract: Novel benzotriazoles of the formula in which R, X1, X2, X3, X4 and Y have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for the preparation of these substances and their use as microbicides in crop protection and in material protection.Type: GrantFiled: April 22, 1999Date of Patent: January 9, 2001Assignee: Bayer AktiengesellschaftInventors: Lutz Assmann, Ralf Tiemann, Martin Kugler, Heinrich Schrage, Klaus Stenzel
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Patent number: 6156891Abstract: Carboxylic acids of formula (1): ##STR1## wherein R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1 -C.sub.3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): ##STR2## The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): ##STR3## wherein R.sup.3 and Q are as defined above, with malonic acid derivatives of formula (6):R.sup.2 CH(COOH).sub.2wherein R.sup.2 is as defined above in the presence of a base.Type: GrantFiled: April 9, 1999Date of Patent: December 5, 2000Assignee: Sumitomo Chemical Company, LimitedInventor: Takashi Furukawa
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Patent number: 6153760Abstract: A method for preparing a lens having UV-absorbing properties involves charging to a mold a monomer mixture comprising lens-forming monomers and an essentially non-UV-absorbing compound, and curing the monomer mixture to form a lens, followed by treating the lens to convert the essentially non-UV-absorbing compound to a UV-absorbing agent.Type: GrantFiled: March 19, 1999Date of Patent: November 28, 2000Assignee: Bausch & Lomb IncorporatedInventor: Jay F. Kunzler
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Patent number: 6147163Abstract: A durability enhancing agent comprising the reaction product of an acrylic oligomer or acrylic polymer and an ultraviolet light absorbing compound, a hindered amine light stabilizer or mixture thereof, said durability enhancing agent further comprising more than one carbamate functional group, or group convertible to a carbamate group, and optionally, including other reactive functionality capable of undergoing a crosslinking reaction. Also included is a curable coating composition comprising the durability enhancing agent, a method for obtaining a coated substrate and the coated article obtained thereby.Type: GrantFiled: December 18, 1996Date of Patent: November 14, 2000Assignee: BASF CorporationInventors: John E. Boisseau, Donald L. St. Aubin, Patricia K. Oberg, John W. Rehfuss
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Patent number: 6130225Abstract: The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each as defined in the description, to a process for their preparation and to their use as herbicides.Type: GrantFiled: February 2, 1999Date of Patent: October 10, 2000Assignee: Bayer AktiengesellschaftInventors: Mark-Wilhelm Drewes, Roland Andree, Markus Dollinger
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Patent number: 6083515Abstract: Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.Type: GrantFiled: January 22, 1999Date of Patent: July 4, 2000Assignee: NitroMed, Inc.Inventors: David S. Garvey, L. Gordon Letts, H. Burt Renfroe, Sang William Tam
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Patent number: 6084104Abstract: The present invention provides a 2,2'-bis(6-benzotriazolylphenol) compound represented by the formula ##STR1## wherein A represents a methylene group or the like,R.sup.1 and R.sup.5 each represent a hydrogen atom, an alkyl group or the like,R.sup.2 represents a hydrogen atom or the like,R.sup.3 represents an alkylene group or the like, andR.sup.4 represents a hydrogen atom or a methyl group.The compound of the invention is useful as an UV absorber. Further, the compound of the invention can be incorporated into a copolymer by copolymerization with a vinyl monomer, and a polymer composition containing the copolymer can be used as an UV absorber.Type: GrantFiled: January 8, 1999Date of Patent: July 4, 2000Assignee: Otsuka Chemical Co., Ltd.Inventors: Shinji Nakano, Emiko Daimon, Minoru Yamamoto, Mitsuo Akada
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Patent number: 6040455Abstract: 5-Sulfonyl substituted benzotriazole UV absorbers are prepared from the corresponding 5-chlorobenzotriazole in a two step, but one-pot process where the second step involves the oxidation of the non-isolated 5-thio substituted benzotriazole using sodium tungstate, hydrogen peroxide and formic acid. The 5-sulfonyl substituted benzotriazoles exhibit enhanced absorption in the near-visible range (over 350 nm) thus providing effective protection to substrates in this critical area of the spectrum.Type: GrantFiled: January 21, 1999Date of Patent: March 21, 2000Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, William Wiggins, Catherine Blake, Albert Carpenter, Wha Chen
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Patent number: 6022937Abstract: This invention relates to novel polyether polyols and to a process for their production. These polyether polyols are prepared by forming a polyhydroxyl group containing component in a first step by the reaction of a triazole-group containing compound with a compound that contains at least one functional group that is capable of reacting with the amine groups of the triazole group containing compound, and reacting the hydroxyl-group containing component with an alkylene oxide to form the polyether polyol of the invention. The present invention also relates to isocyanate-reactive compositions comprising these novel polyether polyols, and to a process for the production of a polyurethane comprising reacting a polyisocyanate with the novel polyether polyols of the present invention.Type: GrantFiled: November 24, 1998Date of Patent: February 8, 2000Assignee: Bayer CorporationInventors: Rick L. Adkins, Harold R. Parsons
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Patent number: 5998628Abstract: Preparations consisting of 5 to 90%, relative to the total weight of the preparations, of mainly neutralized 1-hydroxy-benzotriazole of the formula ##STR1## in which R.sup.1 and R.sup.2, independently of one another, represent hydrogen or methyl andM.sup..sym. is one equivalent of an alkali metal or alkaline earth metal cation or H.sup..sym., whereby M.sup..sym. is present in the range of 85-100 equivalent-% as alkali metal or alkaline earth metal cation and in the range of 15-0 equivalent-% as H.sup..sym.,and the remainder to 100% of water, whereby the water containing preparations have a pH value of from 3 to 11 are nonexplosive and can be handled without danger.For the preparation, unsubstituted 1-hydroxy-benzotriazole is neutralized with an aqueous solution or suspension of a hydroxide, bicarbonate or carbonate of an alkali metal or alkaline earth metal. These preparations may be present as solutions, suspensions or pastes.Type: GrantFiled: March 16, 1998Date of Patent: December 7, 1999Assignee: Bayer AktiengesellschaftInventors: Ferdinand Hagedorn, Helmut Fiege
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Patent number: 5985444Abstract: An ultraviolet light absorbing material that resists blooming and migration is made up of a fluoropolymer and an amide functional ultraviolet light absorbing compound, wherein the polymer and the amide functional ultraviolet light absorbing compound are hydrogen bonded to one another. Polymeric films that contain a polymeric matrix and the ultraviolet light absorbing material are useful as the top layer in multilayer constructions such as retroreflective sheetings and conformable marking sheets.Type: GrantFiled: April 3, 1998Date of Patent: November 16, 1999Assignee: 3M Innovative Properties CompanyInventors: David B. Olson, David M. Burns, Bruce B. Wilson
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Patent number: 5985903Abstract: Novel benzotriazoles of the formula ##STR1## in which R, X.sup.1, X.sup.2, X.sup.3, X.sup.4 and Y have the meanings given in the description,and their acid addition salts and metal salt complexes,a process for the preparation of these substances and their use as microbicides in crop protection and in material protection.Type: GrantFiled: December 19, 1997Date of Patent: November 16, 1999Assignee: Bayer AktiengesellschaftInventors: Lutz Assmann, Ralf Tiemann, Martin Kugler, Heinrich Schrage, Klaus Stenzel
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Patent number: 5962484Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise a photoprotecting effective amount of a novel benzotriazole-substituted polyorganosiloxane/polyorganosilane having one of the formulae (1) to (3): ##STR1## wherein A is a monovalent benzotriazole radical bonded directly to a silicon atom and having the formula (4): ##STR2## the compounds of formulae (1) to (3) are prepared, e.g.Type: GrantFiled: April 9, 1997Date of Patent: October 5, 1999Assignee: Societe L'Oreal S.A.Inventors: Herve Richard, Madeleine Leduc, Alain Lagrange
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Patent number: 5962656Abstract: A photographic element comprising a support having situated thereon at least one silver halide emulsion layer, the layer containing a photographic coupler represented by the formulaCOUP--T.sup.1 --T.sup.2 --(T.sup.3).sub.b --PUGwhereinCOUP is a coupler moiety having a coupling site to which T.sup.1 is attached;T.sup.1 and T3 are timing or linking groups;T.sup.2 is an indazole timing or linking group which, after release from T.sup.1, functions by electron transfer down a conjugated chain to release T.sup.3 or PUG, and which is represented by the formula: ##STR1## wherein ** denotes the point of attachment to T.sup.1 and *** denotes the point of attachment to T.sup.3 or PUG;R.sup.1 and R.sup.2 are independently selected from hydrogen, or an aliphatic, carbocyclic, or heterocyclic group, or may be bonded together to form a 5, 6, or 7 membered ring;V is independently a substituent group as further defined;q is 0, 1, 2, 3 or 4;b is 0 or 1; andPUG is a photographically useful group.Type: GrantFiled: June 10, 1997Date of Patent: October 5, 1999Assignee: Eastman Kodak CompanyInventors: William James Begley, Teh Hsuan Chen, Donald Singleton, Jr., Frank Dino Coms
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Patent number: 5942626Abstract: 2-(2-Hydroxyphenyl)-2H-benzotriazole UV-absorbers substituted at the 5-position of the benzo ring by a thioether group exhibit enhanced absorption in the near visible range (over 350 nm) allowing said compounds to be particularly effective in protecting polymer systems which are prone to degradation caused by actinic irradiation with wavelengths over 350 nm.Type: GrantFiled: April 10, 1996Date of Patent: August 24, 1999Assignee: Ciba Specialty Chemicals CorporationInventors: Roland A.E. Winter, Volker H. von Ahn, Tyler A. Stevenson, Mark S. Holt, Ramanathan Ravichandran
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Patent number: 5932142Abstract: A process for preparing benzotriazolyl-alkylene bisphenol compounds which comprises reacting a 2-hydroxyphenylbenzotriazole and a 2,4-substituted phenol with an aldehyde in the presence of a basic catalyst and an amine compound; benzotriazolyl-alkylene bisphenol compounds obtained by the process; and stabilized organic materials containing the resulting benzotriazolyl-alkylene bisphenol compounds in an amount of 0.01-10 percent by weight. It is possible to prepare the benzotriazolyl-alkylene bisphenol compounds at a high yield, and organic materials can be effectively stabilized with the resulting compounds.Type: GrantFiled: December 8, 1997Date of Patent: August 3, 1999Assignee: Johoku Chemical Co., Ltd.Inventors: Toshiyuki Yamauchi, Eisuke Kanagawa, Hideo Aoki, Kazuyuki Ishihara
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Patent number: 5866635Abstract: A reactive monomer for preparing ultraviolet absorbing polymers has formula (I) wherein R.sup.1 is a halogen or C.sub.1 -C.sub.6 straight or branched chain alkoxy group; and R is a --(CH.sub.2).sub.3 O--, --(CH.sub.2).sub.2 O--, --CH(CH.sub.3)CH.sub.2 O--, --CH.sub.2 CH(CH.sub.3)O(--, --(CH.sub.2).sub.3 OCH.sub.2 --, --(CH.sub.2).sub.2 OCH.sub.2 --, --CH(CH.sub.3)CH.sub.2 OCH.sub.2 --, or --CH.sub.2 CH(CH.sub.3)OCH.sub.2 --group. The compound can be used to produce ultraviolet absorbing polymers, such as those used for ocular devices including contact and intraocular lenses.Type: GrantFiled: February 4, 1998Date of Patent: February 2, 1999Assignee: Wesley Jessen CorporationInventors: Theresa A. Collins, John T. Mulvihill
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Patent number: 5840738Abstract: The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity.Type: GrantFiled: June 25, 1997Date of Patent: November 24, 1998Assignee: Eli Lilly and CompanyInventors: Michael Gregory Bell, Thomas Alan Crowell, Christine Ann Droste, Cynthia Darshini Jesudason, Donald Paul Matthews, John Hampton McDonald, III, David Andrew Neel, Christopher John Rito, Anthony John Shuker, Mark Alan Winter
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Patent number: 5821256Abstract: Novel compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties.Type: GrantFiled: August 15, 1996Date of Patent: October 13, 1998Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus J. Schmitges, Maria Christadler
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Patent number: 5808086Abstract: A 2-hydroxyphenylbenzotriazole is reacted with a formaldehyde and an amino alcohol in an organic solvent in the presence of a basic catalyst. It is thereby possible to obtain bis(2-hydroxyphenyl-3-benzotriazole) methanes efficiently and at a high yield.Type: GrantFiled: July 28, 1997Date of Patent: September 15, 1998Assignee: Johoku Chemical Co., Ltd.Inventors: Naoyuki Sugii, Toshiyuki Yamauchi, Eisuke Kanagawa, Hideo Aoki, Kazuyuki Ishihara
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Patent number: 5786301Abstract: This invention relates to substituted N-benzotriazoles of the formula ##STR1## in which: R.sup.1, R.sup.2, R.sup.3,R.sup.4, R.sup.5,R.sup.6, R.sup.7, X are as defined in the specification. The compounds exhibit herbicidal activity.Type: GrantFiled: August 8, 1996Date of Patent: July 28, 1998Assignee: Zeneca LimitedInventors: Donald R. James, Raymond A. Felix
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Patent number: 5763615Abstract: This invention is directed to certain substituted aryloxy benzotriazole compounds which are herbicidal agents. The invention is further directed to methods for the preparation of the aryloxy benzotriazole compounds.Type: GrantFiled: June 25, 1997Date of Patent: June 9, 1998Assignee: American Cyanamid CompanyInventor: Thomas Andrew Lies
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Patent number: 5750711Abstract: The dicarboxylic acid derivatives according to the invention have the following structure ##STR1## wherein X denotes O, S, (CF.sub.2).sub.m, C(CF.sub.3).sub.2 or CF.sub.2 --CF(CF.sub.3) (m=1 to 10), and R stems from the following compounds: fluoro- or trifluoromethyl- and nitro- or cyanophenols, thiophenols or -aminobenzenes, 4-hydroxy-, 4-mercapto- or 4-aminocoumarins, N-hydroxysuccinimides or N-hydroxymaleimides, 2-hydroxy- or 2-mercaptobenzoxazoles or -benzothiazoles and 1-hydroxy- or 1-mercaptobenzotriazoles.Type: GrantFiled: August 28, 1996Date of Patent: May 12, 1998Assignee: Siemens AktiengesellschaftInventors: Racai Sezi, Hellmut Ahne, Eberhard Kuehn
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Patent number: 5739348Abstract: A method for preparing a compound of formula (III): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, L, Z and p are as defined in the specification;said process preferably comprising either a noble metal catalyzed hydrogenation or a non-catalytic reductive ring closure of an azo dye compound of formula (IV): ##STR2## where R11 is as defined in the specification, thereby performing a reductive ring closure and selective O-deacylation in a single process step.Type: GrantFiled: October 23, 1996Date of Patent: April 14, 1998Assignee: Eastman Kodak CompanyInventors: Lal Chand Vishwakarma, Victor LaVonne Mylroie
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Patent number: 5729322Abstract: A reactive monomer for preparing ultraviolet absorbing polymers has formula (I) wherein R.sup.1 is a halogen or C.sub.1 -C.sub.6 straight or branched chain alkoxy group; and R.sup.2 is a --(CH.sub.2).sub.3 O--, --(CH.sub.2).sub.2 O--, --CH(CH.sub.3)CH.sub.2 O--, --CH.sub.2 CH(CH.sub.3)O--, --(CH.sub.2).sub.3 OCH.sub.2 --, --(CH.sub.2).sub.2 OCH.sub.2 --, --CH(CH.sub.3)CH.sub.2 OCH.sub.2 --, or --CH.sub.2 CH(CH.sub.3)OCH.sub.2 -- group. The compound can be used to produce ultraviolet absorbing polymers, such as those used for ocular devices including contact and intraocular lenses.Type: GrantFiled: November 27, 1996Date of Patent: March 17, 1998Assignee: Wesley-Jessen CorporationInventors: Theresa A. Collins, John T. Mulvihill
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Patent number: 5693460Abstract: This invention provides a silver halide photographic element comprising a silver halide emulsion in reactive association with a dioxide compound represented by the following formula: ##STR1## wherein b is C(O), C(S), C(Se), CH2 or (CH2)2; and R.sup.1 and R.sup.2 are independently H, or aliphatic, aromatic or heterocyclic groups, or R.sup.1 and R.sup.2 together represent the atoms necessary to form a five or six-membered ring or a multiple ring system. This invention further provides a method of making silver halide emulsions containing the dioxide compounds.Type: GrantFiled: June 24, 1996Date of Patent: December 2, 1997Assignee: Eastman Kodak CompanyInventor: Roger Lok
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Patent number: 5686617Abstract: This invention is directed to certain substituted aryloxy benzotriazole compounds which are herbicidal agents. The invention is further directed to methods for the preparation of the aryloxy benzotriazole compounds.Type: GrantFiled: April 5, 1995Date of Patent: November 11, 1997Assignee: American Cyanamid CompanyInventor: Thomas Andrew Lies
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Patent number: 5675015Abstract: 2-(2'-Hydroxyphenyl)-2H-benzotriazoles of formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and Z are defined in the specification, are prepared by catalytic hydrogenation of a suitable o-nitroazo dye compound in the presence of a PtS, Pt, Pd, Pt/Pd or other noble metal hydrogenation catalyst, in the presence of a base, an acid and a hydroxylic solvent.Type: GrantFiled: March 7, 1996Date of Patent: October 7, 1997Assignee: Eastman Kodak CompanyInventors: Lal Chand Vishwakarma, Victor LaVonne Mylroie, Louis Francis Valente, Barry Francis Briffa
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Patent number: 5674670Abstract: A photographic element comprising a light sensitive portion and an ultraviolet absorbing polymer comprising repeating units of a 2'-hydroxphenyl benzotriazole with a 5- or 6-substituent selected from halogen, cyano, carboxy or a sulfonyl, and a 4'-alkoxy group in which the alkylene portion of the alkoxy is linked, in sequence through a first optional bivalent linking group, then an oxygen, sulfur or amino group, then a second optional bivalent linking group, to the polymer chain, provided that the 3'-position is unsubsituted and the 4'-substituent does not have any --NH--, --OH or --SH substituents.Type: GrantFiled: March 18, 1996Date of Patent: October 7, 1997Assignee: Eastman Kodak CompanyInventors: Lal Chand Vishwakarma, Hwei-Ling Yau, Tienteh Chen
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Patent number: 5670654Abstract: A method for preparing a compound of formula (VII): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are defined in the specification;the method comprising:protecting at least --XH on a compound of formula (IV) below to form a protected formula (IV) compound, by forming --X(PG) where PG is a group other than H which is not removed during a subsequent ring closure step: ##STR2## performing a ring closure by reacting the protected formula (IV) compound with a reducing agent to form a compound of formula (VI): ##STR3## wherein Z is H or a protecting group; deprotecting the compound of formula (VI) to form the compound of formula (VII) by replacing PG with H and, when Z is not H, also replacing Z with H.Type: GrantFiled: February 16, 1996Date of Patent: September 23, 1997Assignee: Eastman Kodak CompanyInventor: Lal Chand Vishwakarma
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Patent number: 5637726Abstract: A reactive monomer for preparing ultraviolet absorbing polymers has formula (I) wherein R.sup.1 is a halogen or C.sub.1 -C.sub.6 straight or branched chain alkoxy group; and R is a --(CH.sub.2).sub.3 O--, --(CH.sub.2).sub.2 O--, --CH(CH.sub.3)CH.sub.2 O--, --CH.sub.2 CH(CH.sub.3)O--, --(CH.sub.2).sub.3 OCH.sub.2 --, --(CH.sub.2).sub.2 OCH.sub.2 --, --CH(CH.sub.3)CH.sub.2 OCH.sub.2 --, or --CH.sub.2 CH(CH.sub.3)OCH.sub.2 -- group. The compound can be used to produce ultraviolet absorbing polymers, such as those used for ocular devices including contact and intraocular lenses.Type: GrantFiled: February 7, 1996Date of Patent: June 10, 1997Assignee: Wesley-Jessen CorporationInventors: Theresa A. Collins, John T. Mulvihill
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Patent number: 5631381Abstract: Process for preparing complex pesticidal 1-(haloaryl)heterocyclic compounds by reacting 1-(nitroaryl)heterocycles with metallic halide salts.Type: GrantFiled: June 28, 1996Date of Patent: May 20, 1997Assignee: Rhone-Poulenc Inc.Inventors: Jamin Huang, Scot K. Huber, Philip H. G. Smith, John H. Wilkinson
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Patent number: 5605754Abstract: A thermoplastic article having on the outer surface thereof a protective layer having in admixture a trihydricphenol-benzotriazole ultra violet light absorber and a thermoplastic resin preferably a polycarbonate. The protective layer may be coated on the thermoplastic substrate or it may be co-extruded with the thermoplastic substrate.Type: GrantFiled: November 30, 1995Date of Patent: February 25, 1997Assignee: General Electric CompanyInventors: Josef G. Berndsen, Luca P. Fontana
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Patent number: 5571924Abstract: 2-(2-Hydroxyphenyl)-2H-benzotriazoles can be prepared particularly advantageously by catalytically reducing a suitable o-nitroazobenzene compound to the corresponding N-oxybenzotriazole compound in the presence of hydrazine hydrate, a metal catalyst selected from the group consisting of Raney-Ni and the noble metals, an organic or inorganic base, an organic solvent, and optionally water; followed by isolating said N-oxybenzotriazole compound and converting it to the corresponding 2-(2-hydroxyphenyl)-2H-benzotriazole.Type: GrantFiled: July 12, 1995Date of Patent: November 5, 1996Assignee: Ciba-Geigy CorporationInventors: Jere K. Kaplan, Wolfgang J. Tritschler, Gary Clauson
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Patent number: 5554759Abstract: An ultraviolet absorbing monomer of formula (A): ##STR1## wherein: R.sub.4 and R5 are, independently, a substituted or unsubstituted alkylene with or without intervening oxygen, sulfur or nitrogen atoms; R.sub.6 is H or a substituted or unsubstituted methyl; and the benzo ring, the hydroxy substituted phenyl ring and the phenyl ring of the styryl group may be further substituted or unsubstituted. A method of making such monomers and photographic elements containing UV absorbing polymers formed from such monomers are also provided.Type: GrantFiled: March 9, 1995Date of Patent: September 10, 1996Assignee: Eastman Kodak CompanyInventor: Lal C. Vishwakarma
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Patent number: 5545742Abstract: There is provided a 6-heterocyclyl-1-(substituted phenyl)benzotriazole compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.Type: GrantFiled: May 5, 1995Date of Patent: August 13, 1996Assignee: American Cyanamid Co.Inventors: Michael E. Condon, Alvin D. Crews, Jr., Mark C. Manfredi
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Patent number: 5541204Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.Type: GrantFiled: December 2, 1994Date of Patent: July 30, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Philip M. Sher, William N. Washburn, Kathleen M. Poss
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Patent number: 5523277Abstract: There is provided a 6-heterocyclyl-1-(substituted phenyl)benzotriazole compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that compound for the control of undesirable plant species.Type: GrantFiled: February 10, 1995Date of Patent: June 4, 1996Assignee: American Cyanamid CompanyInventors: Michael E. Condon, Alvin D. Crews, Jr., Mark C. Manfredi