Double Bond Between Ring Members Of The Lactone Ring Or Chalcogen Double Bonded Directly At The 3- Or 4-position Of The Lactone Ring (e.g., Ascorbic Acid, Etc.) Patents (Class 549/315)
  • Patent number: 11097206
    Abstract: Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 24, 2021
    Assignee: Orochem Technologies Inc.
    Inventors: Babu Siddegowda Antharavally, Anil R. Oroskar, Asha A. Oroskar
  • Patent number: 10413894
    Abstract: This invention discloses a method for preparing a catalyst for catalyzing the degradation of organic pollutants in printing and dyeing wastewater by ozone, wherein the catalyst comprises a porous carbon material as a substrate and metal oxide nanoparticles deposited on the surface of the substrate. The method comprises the steps of: allowing a mixture of resorcinol, formaldehyde, trimethylhexadecyl ammonium bromide, multi-walled carbon nanotubes and deionized water to react to form cured product, which is then calcinated and carbonized at high temperature to produce the porous carbon material; impregnating the resulting porous carbon material with nitrate solution, drying the porous carbon material, and calcinating it at high temperature, wherein the absorbed nitrate is decomposed into metal oxide and embedded into the porous carbon material.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: September 17, 2019
    Assignee: The Hong Kong Research Institute of Textiles and Apparel Limited
    Inventors: Songmin Shang, Enling Hu, Xiao-ming Tao
  • Patent number: 9023889
    Abstract: The invention relates to the use of at least one ascorbic acid derivative for the fictionalization of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
  • Patent number: 8957111
    Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 17, 2015
    Assignee: Nutraceutical Corporation
    Inventors: Shayne Morris, Richard Bush
  • Publication number: 20150045426
    Abstract: A complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative covalently bonded with at least one hydrocarbon radical with formula (A) as follows: wherein: •-m 1=1, 2, 3, 4, 5 or 6; •-m 2=0, 1, 2, 3, 4, 5 or 6; and represents the site of the bond with the molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or derivative.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Inventors: Patrick Couvreur, Fatima Zouhiri, Ruxandra Gref, Didier Desmaele
  • Patent number: 8946280
    Abstract: The present invention relates to novel strigolactam derivatives of formula (I) to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants and/or promoting the germination of seeds.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: February 3, 2015
    Assignee: Syngenta Participations AG
    Inventors: Mathilde Denise Lachia, Alain De Mesmaeker, Hanno Christian Wolf, Pierre Joseph Marcel Jung
  • Publication number: 20150011138
    Abstract: The present invention provides a composition, a gypsum board and their preparation method and the use of ascorbic acid as an anti-sagging additive in a gypsum board. Said gypsum board comprises set gypsum prepared from the composition; while said composition comprises hemi-hydrate gypsum, water and a compound comprising group and no carboxylate groups. The set gypsum prepared from the said composition shows better anti-sagging or deformation resisting property. The gypsum board of the present invention is hardly distorted and has stronger stability even in the condition of high humidity, thus improve the quality of the gypsum board to meet the demands of the customer.
    Type: Application
    Filed: December 3, 2012
    Publication date: January 8, 2015
    Applicant: SAINT-GOBAIN PLACO
    Inventors: Xiaotong Gao, Huifen Li, Hao Song, Ke Zhang
  • Publication number: 20140309415
    Abstract: The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a topology of a 12 membered-ring or larger, an ordered mesoporous silica material, or an amorphous silica, said structure containing Lewis acidic Ti4+ or Zr4+ or both Ti4+ and Zr4+ framework centers, said contacting conducted under reaction conditions sufficient to isomerize the glucose to sorbose. The sorbose may be (b) separated or isolated; or (c) converted to ascorbic acid.
    Type: Application
    Filed: March 5, 2014
    Publication date: October 16, 2014
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: MARK E. DAVIS, RAJAMANI GOUNDER
  • Patent number: 8841465
    Abstract: The present invention relates to a method for selective functionalization of metallic single-walled carbon nanotubes with a diazonium derivative. The present invention also relates to the use of the mixture of metallic single-walled carbon nanotubes selectively functionalized and to the semiconducting single-walled carbon nanotubes obtained by means of the method according to the invention, for producing transistor channels in particular in electronics, electron acceptor materials, in particular in photovoltaic systems, nonlinear infrared photon emitters or absorbers, current-conducting electrodes, flexible transparent electrodes, antistatic coatings, chemical detectors, and solar cells.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: September 23, 2014
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventor: Pascale Chenevier
  • Publication number: 20140235684
    Abstract: A metal-salen complex compound responsive drug, which has an antidotal property capable of neutralizing cytotoxicity of a metal-salen complex compound, and an intra-corporeal behavior control system for the metal-salen complex compound are provided. This metal-salen complex compound responsive drug contains an effective amount of a metal chelating agent to suppress side effects by the metal-salen complex compound.
    Type: Application
    Filed: September 19, 2012
    Publication date: August 21, 2014
    Inventors: Yoshihiro Ishikawa, Haruki Eguchi
  • Publication number: 20140194536
    Abstract: The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following general formula (I): wherein X and Y each denotes a hydrogen atom or together denote an oxygen atom, n denotes an integer from 0 to 2, m denotes the integer 1 or 2, and R denotes a hydrophilic group generated by removal of one hydroxyl group from any one selected from the group consisting of glycerol, erythritol, pentaerythritol, diglycerol, triglycerol, xylose, sorbitol, ascorbic acid, glucose, galactose, mannose, dipentaerythritol, maltose, mannitol, and xylitol; as well as a base for injection formulations and depot formulation comprising the same.
    Type: Application
    Filed: February 28, 2014
    Publication date: July 10, 2014
    Applicant: Chemgenesis Incorporated
    Inventors: Yutaka Ikeda, Jun Yamashita, Ichiro Hijikuro, Satoshi Imuta, Yasuhiro Hiroki, Takashi Takahashi
  • Patent number: 8759030
    Abstract: The object of the present invention is to provide a method and a process for producing 2-O-?-glucopyranosyl-L-ascorbic acid where 5-O-?-glucopyranosyl-L-ascorbic acid and 6-O-?-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-?-glucopyranosyl-L-ascorbic acid comprising the steps of allowing ?-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an ?-glucosyl saccharide to form 2-O-?-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-?-glucopyranosyl-L-ascorbic acid.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: June 24, 2014
    Assignee: Hayashibara Co., Ltd.
    Inventors: Kazuhisa Mukai, Keiji Tsusaki, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20140114079
    Abstract: The present invention relates to a method for selective functionalization of metallic single-walled carbon nanotubes with a diazonium derivative. The present invention also relates to the use of the mixture of metallic single-walled carbon nanotubes selectively functionalized and to the semiconducting single-walled carbon nanotubes obtained by means of the method according to the invention, for producing transistor channels in particular in electronics, electron acceptor materials, in particular in photovoltaic systems, nonlinear infrared photon emitters or absorbers, current-conducting electrodes, flexible transparent electrodes, antistatic coatings, chemical detectors, and solar cells.
    Type: Application
    Filed: June 7, 2012
    Publication date: April 24, 2014
    Applicant: Commissariat A L'Energie Atomique et aux Energies Alternatives
    Inventor: Pascale Chenevier
  • Publication number: 20140113963
    Abstract: An antibiotic composition including erythorbyl laurate as an active ingredient and a use thereof are disclosed. Erythorbyl laurate is confirmed to have antibiotic effects on Gram-positive bacteria and thus is used as an antibiotic agent in foods, cosmetics, feeds, and the like and utilized in the form of a hand cleaner and other medicines for external application.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 24, 2014
    Applicant: SNU R&DB Foundation
    Inventors: Pahn Shick Chang, Kyung Min Park, Da Eun Lee, Dong Hyun Kang
  • Publication number: 20140011845
    Abstract: Disclosed are cyclic dione derivatives represented by formula (I), wherein the substituents are as defined in the description. The preparation method, intermediate and use thereof are also provided.
    Type: Application
    Filed: December 30, 2011
    Publication date: January 9, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Stephane Andre Marie Jeanmart, Long Lu, Yaming Wu, Lisheng Mao, Michel Muehlbeach
  • Patent number: 8598228
    Abstract: The invention relates to specific cinnamic acid ascorbates and to the use thereof as UV filters which bond to the skin, and to a process for the preparation thereof, and to preparations comprising these compounds.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: December 3, 2013
    Assignee: Merck Patent GmbH
    Inventors: Thomas Rudolph, Philipp Buehle
  • Publication number: 20130237509
    Abstract: A compound of formula (ascorbate)2Sr:(Ma)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Application
    Filed: February 11, 2013
    Publication date: September 12, 2013
    Applicant: NUTRACEUTICAL CORPORATION
    Inventors: Shayne Morris, Richard Bush
  • Publication number: 20130228192
    Abstract: The invention relates to the use of specific ascorbic acid derivatives for dyeing keratin-containing fibres or as direct dyes for the preparation of a composition for dyeing keratin-containing fibres, and to methods for dyeing keratin-containing fibres, in particular for dyeing human hair.
    Type: Application
    Filed: October 19, 2011
    Publication date: September 5, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Michaela Oberle
  • Publication number: 20130171271
    Abstract: Methods for treating cancers, tumors, and neoplasms using a composition comprising one or more generally regarded as safe (GRAS) compounds selected from the group of components consisting of vitamins, selenium, fatty acids, fatty acid salts, and fatty acid esters, and mixtures of two or more said components, either as a stand-alone treatment or in combination with one or more anti-cancer drugs or devices or other anti-neoplastic agents, treatments, or devices are provided. In some instances, concomitant hyperthermia therapy is employed. Also provided are compositions and kits containing the compositions, for implement various aspects of the invention.
    Type: Application
    Filed: July 25, 2011
    Publication date: July 4, 2013
    Applicant: CHEMOTHERAPEUTICS, LLC
    Inventors: Gary Keeling, Keith B. Hoffman
  • Publication number: 20130149250
    Abstract: The present invention provides a MRI probe of use in detecting and characterizing redox systems in vivo. Also provided are methods of using the probe in MR imaging experiments for diagnosis of disease in a subject, for drug discovery and for probing the redox states of biological systems in vitro.
    Type: Application
    Filed: June 25, 2012
    Publication date: June 13, 2013
    Applicant: The Regents of the University of California
    Inventors: David M. WILSON, Kayvan KESHARI, John KURHANEWICZ, Daniel VIGNERON
  • Patent number: 8404743
    Abstract: Disclosed are compounds comprising a zinc oxide molecule chemically bound to one or more molecules having an acidic hydrogen, such as an organic acid. The invention also provides compositions comprising such compounds and methods of preparing such compounds. The compounds of the invention may be provided in, for example, topical skin formulations, pharmaceutical compositions, or delivery systems for active ingredients.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: March 26, 2013
    Assignee: Mary Kay Inc.
    Inventor: James Swanzy
  • Patent number: 8383837
    Abstract: The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: February 26, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Werner Bonrath, Jocelyn Fischesser
  • Patent number: 8378126
    Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: February 19, 2013
    Assignee: Nutraceutical Corporation
    Inventors: Shayne Morris, Richard Bush
  • Patent number: 8372992
    Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: February 12, 2013
    Assignee: Nutraceutical Corporation
    Inventors: Richard Bush, Shayne Morris
  • Publication number: 20120294866
    Abstract: The present invention provides a liquid pharmaceutical formulation comprising a therapeutic protein, a surfactant and at least an antioxidant selected from the group of radical scavengers, chelating agents or chain terminators.
    Type: Application
    Filed: January 14, 2010
    Publication date: November 22, 2012
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Hanns-Christian Mahler, Satya Krishna Kishore Ravuri
  • Publication number: 20120277180
    Abstract: Provided herein are methods and systems for identifying one or more cofactors such as vitamins for individuals based on the genetic makeup of the individual by detecting the presence or absence of at least one genetic variant, determining a predisposition to cofactor remediable condition, generating a personalized nutritional advice plan based on the genetic variant. Also provided herein are formulations of cofactors determined by the genetic make-up of the individual and methods of determining and producing these formulations.
    Type: Application
    Filed: September 30, 2010
    Publication date: November 1, 2012
    Applicants: VITAPATH GENETICS, INC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Nicholas Marini, Jasper Rine, Dennis Austin Gilbert, Bruce Cohen
  • Patent number: 8278350
    Abstract: An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: October 2, 2012
    Assignee: Showa Denko K.K.
    Inventors: Eiko Kato, Tadashi Yoneda, Eiji Ogata
  • Publication number: 20120220580
    Abstract: Compounds having the structure of general formula I or pharmaceutically acceptable salts thereof which are derivatives of fucoxanthin and fucoxanthol are disclosed. A preparation method of the compound and its use in weight reducing are also disclosed.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 30, 2012
    Applicant: BEIJING GINGKO GROUP BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: YANMEI LI, QINGHUA LIU
  • Patent number: 8242169
    Abstract: An emulsion composition of the present invention includes (A) a salt of a higher fatty acid ester of ascorbic acid-2-phosphoric acid ester, (B) a polyglycerin fatty acid monoester including polyglycerin having a mean polymerization degree of 8 to 12 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, (C) a polyglycerin fatty acid monoester comprising polyglycerin having a mean polymerization degree of 2 to 6 and an unsaturated fatty acid residual group of 14 to 22 carbon atoms, and (D) a hydrocarbon oil, wherein the blending ratio by mass between the component (B) and the component (C) is in the range of 1:1 to 3:1, and the blending ratio by mass between the total of the components (B) and (C) and the component (D) is in the range of 10:1 to 1:4.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: August 14, 2012
    Assignee: Showa Denko K.K.
    Inventors: Tadashi Yoneda, Naoko Ito, Kazuo Furuya
  • Publication number: 20120172580
    Abstract: The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.
    Type: Application
    Filed: September 9, 2010
    Publication date: July 5, 2012
    Applicants: Nippon Soda Co., Ltd., National University Corporation hokkaido University Kita 8-jyo Nishi 5-chome
    Inventors: Chikara Masuta, Hanako Shimura, Shinsuke Sano, Takako Fukagawa
  • Publication number: 20120157370
    Abstract: The invention relates to the use of radical traps in detergents and cleaners in order to improve cleaning performance, in particular for dirt containing polymerizable dyes.
    Type: Application
    Filed: February 23, 2012
    Publication date: June 21, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Andreas Buhl, André Hätzelt
  • Patent number: 8198321
    Abstract: The invention relates to a terpenic composition for use as an anti-micro-organism or anti-viral agent comprising a cyclic terpenic compound obtained from a terpene of the general formula (C5H8)n, n being in the range of 2 to 5; and to a vector-forming organic substance, associated to the said cyclic terpenic compound.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 12, 2012
    Inventor: Aurèle Henri Mannarini
  • Patent number: 8163939
    Abstract: Disclosed is an ascorbic acid derivative or a salt thereof wherein at least one of hydrogen atoms in hydroxy groups at the 2-position and the 3-position of ascorbic acid is substituted by R—O—CH2—CH(OH)—CH2—, R—O—CH2—CH(CH2OH)—, R—CH(CH2OH)—, R—CH(OH)—CH2— (wherein R represents an alkyl group, an alkenyl group or a phenyl group), or a hydroxycyclohexyl group. Also disclosed is a method for producing an ascorbic acid derivative or a salt thereof, which is characterized by reacting ascorbic acid with an epoxy compound such as an alkyl glycidyl ether, an epoxy alkane or an alicyclic epoxy.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: April 24, 2012
    Assignee: Seikwa Kasei Company, Limited
    Inventors: Masato Yoshioka, Norihisa Taira, Akane Kamiyama, Keiichi Uehara, Naoya Hashimoto
  • Publication number: 20120077992
    Abstract: The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of solid, for example metallic, structure which allows cross-flow of the material through the porous element. The invention also relates to various types of uses of the device. A device in accordance with the invention is particularly useful to carry out chemical reactions under homogenous and heterogeneous conditions. Such a device hereinafter also referred as reactor may comprises a tube (1) having a cylindrical wall (2) with one inlet end (3) and one outlet end (4). Arranged in the tube (1) is at least one cylindrical porous element (5) consisting of solid metal structure, wherein said porous element (5) comprises a plurality of hollow spaces that are connected to each other and form an interconnected cavity network and wherein the at least one porous element (5) and the cylindrical wall (2) are made in one piece.
    Type: Application
    Filed: June 14, 2010
    Publication date: March 29, 2012
    Inventors: Cédric Hutter, Francesco Mascarello, Philipp Von Rohr, David Ruppen
  • Publication number: 20120052028
    Abstract: The invention relates to specific cinnamic acid ascorbates and to the use thereof as UV filters which bond to the skin, and to a process for the preparation thereof, and to preparations comprising these compounds.
    Type: Application
    Filed: April 12, 2010
    Publication date: March 1, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Thomas Rudolph, Philipp Buehle
  • Publication number: 20110306133
    Abstract: Disclosed are a culture medium, an additive, and a method for efficiently inducing the differentiation of mammalian somatic stem cells into cells having the characteristics of adipocytes under conditions of serum-free or low-serum culture medium. The culture medium for inducing the differentiation of mammalian somatic stem cells into adipocytes comprises a basal medium for culturing mammalian cells, an agent for inducing the differentiation of mammalian somatic stem cells into adipocytes, biotin, a ligand for endothelial cell differentiation gene (Edg) family receptors, vitamin C, and HEPES, which culture medium is serum-free or contains a low concentration of serum.
    Type: Application
    Filed: February 18, 2010
    Publication date: December 15, 2011
    Inventor: Yoshiyuki Hotta
  • Publication number: 20110059034
    Abstract: Disclosed is an ascorbic acid derivative or a salt thereof wherein at least one of hydrogen atoms in hydroxy groups at the 2-position and the 3-position of ascorbic acid is substituted by R—O—CH2—CH(OH)—CH2—, R—O—CH2—CH(CH2OH)—, R—CH(CH2OH)—, R—CH(OH)—CH2— (wherein R represents an alkyl group, an alkenyl group or a phenyl group), or a hydroxycyclohexyl group. Also disclosed is a method for producing an ascorbic acid derivative or a salt thereof, which is characterized by reacting ascorbic acid with an epoxy compound such as an alkyl glycidyl ether, an epoxy alkane or an alicyclic epoxy.
    Type: Application
    Filed: August 21, 2008
    Publication date: March 10, 2011
    Inventors: Masato Yoshioka, Norihisa Taira, Akane Kamiyama, Keiichi Uehara, Naoya Hashimoto
  • Publication number: 20110021626
    Abstract: The invention relates to a conjugated dendrimer that comprises at least one water-soluble dendrimer and at least one vitamin C molecule. The conjugated dendrimer can be used e.g. for preparing cosmetic or pharmaceutical compositions. The dendrimers have a good vitamin C load capacity and are biocompatible.
    Type: Application
    Filed: January 21, 2009
    Publication date: January 27, 2011
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
    Inventors: Didier Astruc, Jaime Ruiz Aranzaes, Élodie Boisselier
  • Publication number: 20110008306
    Abstract: The present invention provides methods of treating creatine responsive states, such as a neurological disorder (i.e., Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis and creatine transporter defect) or a skin disorder, by administering a creatine-ligand compound, alone or in combination with an anti-inflammatory compound, to a subject.
    Type: Application
    Filed: February 2, 2010
    Publication date: January 13, 2011
    Inventor: Belinda Tsao NIVAGGIOLI
  • Publication number: 20100322881
    Abstract: The invention relates to compounds of formula (I), wherein R1, R2, R3, R4 have the meaning cited in the claims, to methods for the production thereof, agents containing said compounds and to their use for the functionalisation of matrices, in particular their use as skin and/or hair-binding UV filters.
    Type: Application
    Filed: January 15, 2009
    Publication date: December 23, 2010
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventors: Thomas Rudolph, Philipp Buehle
  • Patent number: 7851526
    Abstract: Polymers initiated with furanones and compositions containing such polymers are suitable for use in making textiles, medical devices, delivery agents, packaging materials, coatings for such items, and the like.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: December 14, 2010
    Assignee: Tyco Healthcare Group LP
    Inventors: Joshua B. Stopek, Joseph Hotter, Steve Tsai
  • Patent number: 7846903
    Abstract: A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wherein R represents a hydrophilic group; X and Y each independently represent a hydrogen atom or together form an oxygen atom; n is an integer of 0 to 4; and m is an integer of 0 to 3.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: December 7, 2010
    Assignees: National Institute of Advanced Industrial Science and Technology, Kuraray Co., Ltd., Cytopathfinder, Inc.
    Inventors: Masakatsu Hato, Yoshiji Fujita, Toshitaka Ota, Masahisa Tanomura, Manzo Shiono
  • Publication number: 20100297261
    Abstract: A food product comprising a source of at least one metal ion selected from Fe and Cu ions and an ascorbic acid derivative substituted in the 2-position, wherein the molar ratio of the metal ion or metal ions in the source of metal ions to the ascorbic acid derivative is from 1:0.5 to 1:15.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 25, 2010
    Inventors: Salomon Leendert Abrahamse, van Amelsvoort Netherlands Johannes, van Buuren Nicodemus M. Bernardus, Duchateau Servaac M.J.E. Gustaaf
  • Patent number: 7838690
    Abstract: The present invention relates to a method for preparing 3-O-substituted ascorbic acid derivatives represented by formula 1, in which 5,6-O-isopropylidene ascorbic acid is reacted with a halide in an organic solvent in the presence of the anion exchange resin absorbed with multi-iodine anions and then deprotected. The method of the present invention has an advantage of providing a target compound with high purity and high yield by finishing the reaction within a short period of time at room temperature.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: November 23, 2010
    Assignee: Cosmol Co. Ltd
    Inventors: Sung-Ryoung Park, Geon-Min Lee
  • Publication number: 20100217017
    Abstract: The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a poly-hydroxy compound in the presence of a catalyst containing gold in a solvent.
    Type: Application
    Filed: June 5, 2008
    Publication date: August 26, 2010
    Inventors: Werner Bonrath, Jocelyn Fischesser
  • Publication number: 20100203135
    Abstract: Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses.
    Type: Application
    Filed: March 14, 2006
    Publication date: August 12, 2010
    Inventors: Paul Kemp, David Shering, Andrew Shering, Penny Johnson, Damian Marshall
  • Patent number: 7741496
    Abstract: The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: June 22, 2010
    Assignee: Corum Inc.
    Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu
  • Publication number: 20100113590
    Abstract: Disclosed is an ADAM inhibitor which enables to prevent or improve conditions caused by increase in ADAM activity. Specifically disclosed is an ascorbic acid derivative represented by the general formula (1) below or a salt thereof. [chemical formula 1] (1), wherein R represents a linear or branched alkyl group having 1 to 22 carbon atoms.
    Type: Application
    Filed: December 27, 2007
    Publication date: May 6, 2010
    Applicant: Shiseido Company, Ltd.
    Inventors: Takuya Hiruma, Hirotada Fukunishi, Masaru Suetsugu, Yukiko Matsunaga, Satoshi Amano, Michio Shibata
  • Patent number: 7696360
    Abstract: The invention relates to a method for the separation of ascorbic acid from a mixture containing ascorbic acid and 2-keto-L-gulonic acid in a polar, preferably aqueous solvent, by means of liquid/liquid extraction using an amide. The method preferably also comprises steps for the back-extraction of the ascorbic acid, recycling of the extraction solvent and/or the back extraction solvent and for isolation of the ascorbic acid from the back extraction solvent. The invention further relates to a method for the production of ascorbic acid from KGA and isolation of the ascorbic acid so produced.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: April 13, 2010
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Kaibel, Martin Merger, Thomas Domschke, Petra Deckert, Friedrich Sauer
  • Publication number: 20100056809
    Abstract: The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 4, 2010
    Applicant: CORUM INC.
    Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu