Sulfur Or -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To Acyclic Chalcogen Patents (Class 549/317)
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Patent number: 11346829Abstract: The present disclosure provides methods for detection and quantification of trimethylamine (TMA) or trimethylamine oxide (TMAO) comprising passing a sample over a sensor comprising a substrate having a plurality of chemically responsive dyes selected from the following classes of chemically responsive dyes: metal-containing dyes, pH indicators, or solvatochromic/vapochromic dyes. The disclosure also provides devices and sensors for the detection and quantification of TMA, and methods of diagnosing a subject having trimethylaminuria (TMAU).Type: GrantFiled: May 17, 2017Date of Patent: May 31, 2022Assignee: The Board of Trustees of the University of IllinoisInventors: Kenneth S. Suslick, Zheng Li, Maria K. LaGasse
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Patent number: 8987476Abstract: The present disclosure relates to compounds of formula I wherein the substituents are as defined in claim 1. The compounds are suitable intermediates in the preparation of herbicidally active 4-phenyl-3,5-pyrandiones, 4-phenyl-3,5-thiopyrandiones and 6-phenylcyclohexane-1,3,5-triones.Type: GrantFiled: January 17, 2014Date of Patent: March 24, 2015Assignee: Syngenta LimitedInventor: James Nicholas Scutt
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Patent number: 8895761Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.Type: GrantFiled: December 11, 2008Date of Patent: November 25, 2014Assignees: Syngenta Limited, Syngenta Crop Protection, LLCInventors: Michel Muehlebach, Christopher John Mathews, James Nicholas Scutt, Stephane Andre Marie Jeanmart, Mangala Govenkar
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Patent number: 8722729Abstract: The present invention relates to a compound with the following general formula (I): in which: R1 is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation; and R2 and R3 are, independently or simultaneously: a hydrogen or a C1-C3 alkyl or a phenyl; and R4: a hydrogen atom or COR1?, where R1? is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation, advantageously 1 to 6 and preferably 1 to 4.Type: GrantFiled: June 8, 2010Date of Patent: May 13, 2014Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Stéphane Poigny, Sylvie Daunes-Marion, Nathalie Castex Rizzi, Patrick Bogdanowicz
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Patent number: 8703975Abstract: The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children.Type: GrantFiled: December 24, 2009Date of Patent: April 22, 2014Assignees: Wuxi Hongrui Bio-Pharma-Tech Co., Ltd.Inventors: Luhong Tang, Ajuan Dai, Ze Wang, Yang Sun, Xinning Liu, Lingyan Xu, Xin Fang, Shuang Qiu, Yaqing Cao, Xiaomin Xu, Ruixia Jiang, Chao Wu
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Publication number: 20120288461Abstract: Ascorbic acid esters of resveratrol and topical compositions containing same.Type: ApplicationFiled: November 11, 2011Publication date: November 15, 2012Inventors: Daniel H. Maes, Fatemeh Mohammadi, Lisa Qu, Anna Czarrnota, Thomas Mammone, Lieve Declercq, Julius R. Zecchino
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Publication number: 20120172580Abstract: The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.Type: ApplicationFiled: September 9, 2010Publication date: July 5, 2012Applicants: Nippon Soda Co., Ltd., National University Corporation hokkaido University Kita 8-jyo Nishi 5-chomeInventors: Chikara Masuta, Hanako Shimura, Shinsuke Sano, Takako Fukagawa
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Publication number: 20120157370Abstract: The invention relates to the use of radical traps in detergents and cleaners in order to improve cleaning performance, in particular for dirt containing polymerizable dyes.Type: ApplicationFiled: February 23, 2012Publication date: June 21, 2012Applicant: Henkel AG & Co. KGaAInventors: Christian Kropf, Andreas Buhl, André Hätzelt
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Patent number: 8198321Abstract: The invention relates to a terpenic composition for use as an anti-micro-organism or anti-viral agent comprising a cyclic terpenic compound obtained from a terpene of the general formula (C5H8)n, n being in the range of 2 to 5; and to a vector-forming organic substance, associated to the said cyclic terpenic compound.Type: GrantFiled: November 16, 2007Date of Patent: June 12, 2012Inventor: Aurèle Henri Mannarini
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Publication number: 20120115897Abstract: The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children.Type: ApplicationFiled: December 24, 2009Publication date: May 10, 2012Applicants: WUXI HONGRUI BIO-PHARMA-TECH CO., LTD .Inventors: Luhong Tang, Ajuan Dai, Ze Wang, Yang Sun, Xinning Liu, Lingyan Xu, Xin Fang, Shuang Qiu, Yaqing Cao, Xiaomin Xu, Ruixia Jiang, Chao Wu
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Publication number: 20120076744Abstract: The present invention relates to a compound with the following general formula (I): in which: R1 is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation; and R2 and R3 are, independently or simultaneously: a hydrogen or a C1-C3 alkyl or a phenyl; and R4: a hydrogen atom or COR1?, where R1? is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation, advantageously 1 to 6 and preferably 1 to 4.Type: ApplicationFiled: June 8, 2010Publication date: March 29, 2012Applicant: PIERRE FABRE DERMO-COSMETIQUEInventors: Stéphane Poigny, Sylvie Daunes-Marion, Nathalie Castex Rizzi, Patrick Bogdanowicz
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Patent number: 7989642Abstract: The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a simple and easy means; highly unsaturated fatty acid esters of ascorbic acid which are improved in stability by powdering; and compositions containing the powdered highly unsaturated fatty acid esters of ascorbic acid. Specifically, a process for powdering a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I): RCO-A [wherein RCO— is acyl derived from a highly unsaturated fatty acid; and A is an ascorbic acid residue bonded through an —O— linkage resulting from an hydroxyl group of ascorbic acid], characterized by mixing a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I) with an aqueous solution of a water-soluble filler to form an emulsion and dehydrating and drying the emulsion by a spray drying method.Type: GrantFiled: February 27, 2004Date of Patent: August 2, 2011Assignee: Suntory Holdings LimitedInventor: Harukazu Fukami
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Publication number: 20100255117Abstract: The instant invention provides methods and compositions for the treatment of cancer.Type: ApplicationFiled: April 6, 2008Publication date: October 7, 2010Applicant: The Johns Hopkins UniversityInventors: Shyam Biswal, Anju Singh, Deepti Malhotra
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Publication number: 20100167936Abstract: The invention relates to the use of at least one ascorbic acid derivative for the functionalisation of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.Type: ApplicationFiled: June 27, 2007Publication date: July 1, 2010Inventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
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Publication number: 20090214452Abstract: The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligo arginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related.Type: ApplicationFiled: December 28, 2006Publication date: August 27, 2009Inventor: Jacob M. Waugh
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Patent number: 7074826Abstract: The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition comprising a compound mentioned above, or a pharmaceutically acceptable salt thereof where salt formation occurs, is administered to the mammal in an amount sufficient to elicit a chemopreventative effect or a chemoprotective effect or a therapeutic effect or a prophylactic effect.Type: GrantFiled: October 3, 2003Date of Patent: July 11, 2006Assignee: Encore Pharmaceuticals, Inc.Inventors: William J. Wechter, Elaine Benaksas Schwartz
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Patent number: 7045546Abstract: Novel derivatives of ascorbic acid and compositions comprising them are provided. The novel derivatives are of the following general formula (I): where R1 is a C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl ; R2 is a group of the following formula (II) wherein R5 or R6 are the same or different and represent hydrogen, a C1–C4 alkyl, or R5 is C1–C4 alkyl group and R6 is a metal cation or ammonium cation; R3 or R4 are the same or different and represent hydrogen, C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl.Type: GrantFiled: July 26, 2001Date of Patent: May 16, 2006Assignee: Tagra Biotechnologies Ltd.Inventors: Vladimir Babtsov, Yury Shapiro, Emma Kvitnitsky, Valery Belakhov
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Patent number: 6828348Abstract: L-Ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; and a process for producing the above-described adduct characterized by comprising extracting a solution containing L-ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester with a solvent, distilling off the solvent, and adding to the residue 1-propanol mixed with an organic solvent followed by crystallization.Type: GrantFiled: November 25, 2003Date of Patent: December 7, 2004Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Noriko Saito, Kazuhiko Yamada, Genta Maruyama
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Publication number: 20030119753Abstract: A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxident, and is used for treating damage to skin comprising applying the topical composition to the skin.Type: ApplicationFiled: August 23, 2002Publication date: June 26, 2003Inventors: Waheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
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Publication number: 20030113362Abstract: A biochemical compound is described comprising ascorbic acid and at least one essential aminoacid, wherein the ascorbic acid is covalently bound to the aminoacid. The present invention provides a method of use of a biochemical compound where ascorbate molecules are covalently bound to essential amino acids, nonessential amino acids and amino acids that do not occur in protein to prevent oxidation.Type: ApplicationFiled: August 23, 2002Publication date: June 19, 2003Inventors: Waheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
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Publication number: 20020037923Abstract: The invention provides a resorcinol derivative and a method of using the resorcinol derivative to attenuate the growth of a neoplasm.Type: ApplicationFiled: August 13, 2001Publication date: March 28, 2002Inventor: Craig R. Travis
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Patent number: 6136832Abstract: The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones; 5-[(4-aryl)-3-butynyl]-3,4-dihydroxy-2(5H)-furanones; 5-(2-arylthio)ethyl-3,4-dihydroxy-2(5H)-furanones; and 5-(2-aryloxy)ethyl-3,4-dihydroxy-2(5H)-furanones. This invention further relates to the use of the above mentioned compounds as anti-inflammatory agents through their action as mixed inhibitors of lipid peroxidation, 5-lipoxygenase, cyclooxygenase-1 and cyclooxygenase-2. The invention further relates to the use of such compounds in the treatment of chronic inflammatory disorders such as asthma, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, acute respiratory distress syndrome, and central nervous system disorders such as Alzheimer's and Parkinson's disease wherein reactive oxygen species and inflammatory mediators are contributing deleterious factors.Type: GrantFiled: May 19, 1999Date of Patent: October 24, 2000Assignee: Oxis International Inc.Inventors: Allen T. Hopper, John A. Ziemniak, Robert E. Johnson
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Patent number: 5679801Abstract: There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R;Y is --O-- or --S--;R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof;which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals.Type: GrantFiled: May 15, 1995Date of Patent: October 21, 1997Assignee: American Home Products CorporationInventors: Craig E. Caufield, James M. Rinker
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Patent number: 5516919Abstract: Metal salts or substitutted or non-substituted ammonium salts of ascorbic acid derivatives can be produced in high yield by treating an acidic aqueous solution containing ascorbic acid-2-phosphate or ascorbic acid-2-sulfate with a porous adsorbent such as activated carbon, followed by treating the adsorbent with a basic aqueous solution containing e.g. a metal salt of an organic acid or substituted or non-substituted ammonium salt ion to elute the desired salt of ascorbic acid derivative.Type: GrantFiled: April 18, 1995Date of Patent: May 14, 1996Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Atsunori Sano, Kuniaki Okamoto, Jun Ebashi
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Patent number: 5242945Abstract: There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R;R is ##STR2## and further when Y=S, R may also be --(CH.sub.2).sub.e CH.sub.3 ; Y is --O--or --S--;R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl;R.sup.3 is indolyl, furyl, phenyl or phenyl optionally mono- or disubstituted independently by alkyl of 1-7 carbon atoms, --C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3, haloloweralkyl, perfluoroalkyl, lower alkoxy, aryl alkoxy, halo or nitro;R.sup.4 and R.sup.5 are, independently, --COCH.sub.2 R.sup.7, --CO.sub.2 R.sup.7, --CONHR.sup.7, geranyl or CH.sub.2 R.sup.3 ;R.sup.6 is hydrogen or lower alkyl;R.sup.7 is geranyl and any moiety selected from R other than ##STR3## A and B are, independently, --O--, --S-- or --NR.sup.6 --; and a is 0-8;b is 1-10 when Y=S, and 2-10 when Y=O;c is 1-3;d is 0-9; ande is 3-18;which by virtue of their ability to inhibit PLA.sub.Type: GrantFiled: April 12, 1991Date of Patent: September 7, 1993Assignee: American Home Products CorporationInventors: Craig E. Caufield, James M. Rinker
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Patent number: 5239087Abstract: The present invention relates to a process for the production of dipotassium-ascorbate-2-sulfate-dihydrate, a vitamin C derivative. It is used, among other things, as an additive to fish feed. In the process according to the process according to the invention, trimethylamine-sulfur-trioxide complex is added in only slight molar excess to a concentrated solution of potassium-L-ascorbate in water, and the pH value of this reaction mixture is set by successive additions of potassium hydroxide at a value in the range between 9.5 and 10.5, and is kept at this value for the duration of the reaction. The process permits the profitable production of dipotassium-ascorbate-2-sulfate-dihydrate on a large industrial scale. It is also explained how trimethylamine-sulfur-trioxide complex can be recovered from trimethylamine which occurs as a by-product during the production of dipotassium-ascorbate-2-sulfate.Type: GrantFiled: July 17, 1990Date of Patent: August 24, 1993Assignee: Enco Engineering Chur AGInventors: Guberovic Zeljko, Marijan Hohnjec, Josip Kuftinec, Milan Oklobdzija
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Patent number: 5189057Abstract: A compound of the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each is a hydrocarbon residue, R.sub.3 is a sulfo group or phosphono group, --CO--R.sub.4 is an esterified carboxyl group, a thiol-esterified carboxyl group or an amidated carboxyl group; and .about. represents the absolute configuration of R or S, or its salt, which is useful for preventing and treating thrombosis.Type: GrantFiled: July 19, 1991Date of Patent: February 23, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Koichi Kato, Hirotomo Masuya, Moriya Norihiko
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Patent number: 4997958Abstract: A process for the manufacture of 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid by esterifying the ascorbic acid with an aliphatic C.sub.2-20 -carboxylic acid halide in the presence of a N,N-dialkyl-alkanecarboxylic acid amide, of a cyclic amide of the 1-methyl-2-pyrrolidone type, of a tetraalkylcarbamide such as tetramethylurea, of a cyclic carbamide of the 1,3-dimethyl-2-imidazolidinone type or of a phosphoric acid triamide of the hexamethylphosphoric acid triamide type. The 6-ascorbyl linolate which can be manufactured in this manner is novel and is likewise an object of the present invention. The thus-manufacturable 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid are important alternative application forms of L-ascorbic acid (vitamin C).Type: GrantFiled: March 10, 1989Date of Patent: March 5, 1991Assignee: Hoffmann-La Roche Inc.Inventors: Horst Pauling, Christof Wehrli
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Patent number: 4876273Abstract: New polyether antibiotic A80577, its acyl ester and alkyl ether derivatives, and salts thereof, are useful antibacterial agents and increase feed-utilization efficiency in animals. Methods of making A80577 by culture of Actinomadura verrucosospora, NRRL 18236, and compositions containing an A80577 compound also are provided.Type: GrantFiled: July 18, 1988Date of Patent: October 24, 1989Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Raymond C. Yao
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Patent number: 4822898Abstract: An ascorbic acid or erythorbic acid derivative represented by the following general formula: ##STR1## wherein n represents an integer of 4 to 20; and a process for producing said ascorbic acid or erythorbic acid derivative which comprises heat-treating 2,5,6-triacyl-substituted-ascorbic acid or -erythorbic acid represented by the following general formula: ##STR2## wherein n represents an integer of 4 to 20, in the presence of water and/or a lower aliphatic alcohol at a temperature of 30.degree. C. to 100.degree. C. and thereby selectively eliminating only the acyl group of the 2-position.Type: GrantFiled: September 12, 1986Date of Patent: April 18, 1989Assignee: Sumitomo Chemical Company, LimitedInventors: Kazuo Kamaya, Yukihisa Takisawa
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Patent number: 4727164Abstract: A solution of L-ascorbic acid and a solution of para amino benzoic acid are mixed and the mixture evaporated to permit recovery of a solid compound. The compound is administered to a host to reduce thrombotic tendencies.Type: GrantFiled: January 9, 1986Date of Patent: February 23, 1988Inventors: Philip N. Sawyer, Leon D. Freeman
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Patent number: 4705869Abstract: Fatty acid esters of ascorbic acid are prepared by a process in which a homogeneous mixture of(a) ascorbic acid,(c) concentrated sulfuric acid having a concentration of not less than 96% and(c) a methyl or ethyl ester of a fatty acid of 12 to 18 carbon atomsis reacted at from 20.degree. to 50.degree. C.Using the novel process, the fatty acid esters of ascorbic acid, in particular ascorbyl palmitate, which are very desirable antioxidants are obtained by a procedure which is technically simpler and hence cheaper than the conventional processes, but in equally good yields.Type: GrantFiled: August 2, 1985Date of Patent: November 10, 1987Assignee: BASF AktiengesellschaftInventors: Helmut Nickels, Alfred Hackenberger
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Patent number: 4423236Abstract: Novel condensation products between enediol ketolactones such as 5,6-0-isopropylidene ascorbic acid and 2-chloroethyl isocyanates are shown to have potent antitumor activity probably without the release of alkylating agents in vivo. While the structures of the products are not readily elucidated, activity is found to exceed that of BCNU (bis-(2-chloroethyl)-N-nitrosourea) and parallel that of the toxic and highly effective nitrosourea, MeCCNU (1-(4-trans-methylcyclohexyl)-3-(2-chloroethyl)-3-nitrosourea). Preferred compounds are condensation products of ##STR1## wherein R.sub.2 and R.sub.3 are a lower alkyl group containing 1 to 3 carbon atoms or H andhal--CH.sub.2 --CH.sub.2 --N.dbd.C.dbd.O (B)wherein hal is I, Br or Cl.Type: GrantFiled: October 23, 1981Date of Patent: December 27, 1983Assignee: National Foundation for Cancer Research, Inc.Inventor: Andrew J. Welebir