Sulfur Or -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To Acyclic Chalcogen Patents (Class 549/317)
  • Patent number: 11346829
    Abstract: The present disclosure provides methods for detection and quantification of trimethylamine (TMA) or trimethylamine oxide (TMAO) comprising passing a sample over a sensor comprising a substrate having a plurality of chemically responsive dyes selected from the following classes of chemically responsive dyes: metal-containing dyes, pH indicators, or solvatochromic/vapochromic dyes. The disclosure also provides devices and sensors for the detection and quantification of TMA, and methods of diagnosing a subject having trimethylaminuria (TMAU).
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: May 31, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth S. Suslick, Zheng Li, Maria K. LaGasse
  • Patent number: 8987476
    Abstract: The present disclosure relates to compounds of formula I wherein the substituents are as defined in claim 1. The compounds are suitable intermediates in the preparation of herbicidally active 4-phenyl-3,5-pyrandiones, 4-phenyl-3,5-thiopyrandiones and 6-phenylcyclohexane-1,3,5-triones.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 24, 2015
    Assignee: Syngenta Limited
    Inventor: James Nicholas Scutt
  • Patent number: 8895761
    Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: November 25, 2014
    Assignees: Syngenta Limited, Syngenta Crop Protection, LLC
    Inventors: Michel Muehlebach, Christopher John Mathews, James Nicholas Scutt, Stephane Andre Marie Jeanmart, Mangala Govenkar
  • Patent number: 8722729
    Abstract: The present invention relates to a compound with the following general formula (I): in which: R1 is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation; and R2 and R3 are, independently or simultaneously: a hydrogen or a C1-C3 alkyl or a phenyl; and R4: a hydrogen atom or COR1?, where R1? is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation, advantageously 1 to 6 and preferably 1 to 4.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: May 13, 2014
    Assignee: Pierre Fabre Dermo-Cosmetique
    Inventors: Stéphane Poigny, Sylvie Daunes-Marion, Nathalie Castex Rizzi, Patrick Bogdanowicz
  • Patent number: 8703975
    Abstract: The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: April 22, 2014
    Assignees: Wuxi Hongrui Bio-Pharma-Tech Co., Ltd.
    Inventors: Luhong Tang, Ajuan Dai, Ze Wang, Yang Sun, Xinning Liu, Lingyan Xu, Xin Fang, Shuang Qiu, Yaqing Cao, Xiaomin Xu, Ruixia Jiang, Chao Wu
  • Publication number: 20120288461
    Abstract: Ascorbic acid esters of resveratrol and topical compositions containing same.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 15, 2012
    Inventors: Daniel H. Maes, Fatemeh Mohammadi, Lisa Qu, Anna Czarrnota, Thomas Mammone, Lieve Declercq, Julius R. Zecchino
  • Publication number: 20120172580
    Abstract: The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.
    Type: Application
    Filed: September 9, 2010
    Publication date: July 5, 2012
    Applicants: Nippon Soda Co., Ltd., National University Corporation hokkaido University Kita 8-jyo Nishi 5-chome
    Inventors: Chikara Masuta, Hanako Shimura, Shinsuke Sano, Takako Fukagawa
  • Publication number: 20120157370
    Abstract: The invention relates to the use of radical traps in detergents and cleaners in order to improve cleaning performance, in particular for dirt containing polymerizable dyes.
    Type: Application
    Filed: February 23, 2012
    Publication date: June 21, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Andreas Buhl, André Hätzelt
  • Patent number: 8198321
    Abstract: The invention relates to a terpenic composition for use as an anti-micro-organism or anti-viral agent comprising a cyclic terpenic compound obtained from a terpene of the general formula (C5H8)n, n being in the range of 2 to 5; and to a vector-forming organic substance, associated to the said cyclic terpenic compound.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 12, 2012
    Inventor: Aurèle Henri Mannarini
  • Publication number: 20120115897
    Abstract: The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children.
    Type: Application
    Filed: December 24, 2009
    Publication date: May 10, 2012
    Applicants: WUXI HONGRUI BIO-PHARMA-TECH CO., LTD .
    Inventors: Luhong Tang, Ajuan Dai, Ze Wang, Yang Sun, Xinning Liu, Lingyan Xu, Xin Fang, Shuang Qiu, Yaqing Cao, Xiaomin Xu, Ruixia Jiang, Chao Wu
  • Publication number: 20120076744
    Abstract: The present invention relates to a compound with the following general formula (I): in which: R1 is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation; and R2 and R3 are, independently or simultaneously: a hydrogen or a C1-C3 alkyl or a phenyl; and R4: a hydrogen atom or COR1?, where R1? is a hydrocarbon chain of an unsaturated fatty acid from C12 to C24 including at least one unsaturation, advantageously 1 to 6 and preferably 1 to 4.
    Type: Application
    Filed: June 8, 2010
    Publication date: March 29, 2012
    Applicant: PIERRE FABRE DERMO-COSMETIQUE
    Inventors: Stéphane Poigny, Sylvie Daunes-Marion, Nathalie Castex Rizzi, Patrick Bogdanowicz
  • Patent number: 7989642
    Abstract: The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a simple and easy means; highly unsaturated fatty acid esters of ascorbic acid which are improved in stability by powdering; and compositions containing the powdered highly unsaturated fatty acid esters of ascorbic acid. Specifically, a process for powdering a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I): RCO-A [wherein RCO— is acyl derived from a highly unsaturated fatty acid; and A is an ascorbic acid residue bonded through an —O— linkage resulting from an hydroxyl group of ascorbic acid], characterized by mixing a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I) with an aqueous solution of a water-soluble filler to form an emulsion and dehydrating and drying the emulsion by a spray drying method.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: August 2, 2011
    Assignee: Suntory Holdings Limited
    Inventor: Harukazu Fukami
  • Publication number: 20100255117
    Abstract: The instant invention provides methods and compositions for the treatment of cancer.
    Type: Application
    Filed: April 6, 2008
    Publication date: October 7, 2010
    Applicant: The Johns Hopkins University
    Inventors: Shyam Biswal, Anju Singh, Deepti Malhotra
  • Publication number: 20100167936
    Abstract: The invention relates to the use of at least one ascorbic acid derivative for the functionalisation of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.
    Type: Application
    Filed: June 27, 2007
    Publication date: July 1, 2010
    Inventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
  • Publication number: 20090214452
    Abstract: The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligo arginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 27, 2009
    Inventor: Jacob M. Waugh
  • Patent number: 7074826
    Abstract: The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition comprising a compound mentioned above, or a pharmaceutically acceptable salt thereof where salt formation occurs, is administered to the mammal in an amount sufficient to elicit a chemopreventative effect or a chemoprotective effect or a therapeutic effect or a prophylactic effect.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: July 11, 2006
    Assignee: Encore Pharmaceuticals, Inc.
    Inventors: William J. Wechter, Elaine Benaksas Schwartz
  • Patent number: 7045546
    Abstract: Novel derivatives of ascorbic acid and compositions comprising them are provided. The novel derivatives are of the following general formula (I): where R1 is a C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl ; R2 is a group of the following formula (II) wherein R5 or R6 are the same or different and represent hydrogen, a C1–C4 alkyl, or R5 is C1–C4 alkyl group and R6 is a metal cation or ammonium cation; R3 or R4 are the same or different and represent hydrogen, C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: May 16, 2006
    Assignee: Tagra Biotechnologies Ltd.
    Inventors: Vladimir Babtsov, Yury Shapiro, Emma Kvitnitsky, Valery Belakhov
  • Patent number: 6828348
    Abstract: L-Ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; and a process for producing the above-described adduct characterized by comprising extracting a solution containing L-ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester with a solvent, distilling off the solvent, and adding to the residue 1-propanol mixed with an organic solvent followed by crystallization.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: December 7, 2004
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Kazumi Ogata, Noriko Saito, Kazuhiko Yamada, Genta Maruyama
  • Publication number: 20030119753
    Abstract: A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxident, and is used for treating damage to skin comprising applying the topical composition to the skin.
    Type: Application
    Filed: August 23, 2002
    Publication date: June 26, 2003
    Inventors: Waheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
  • Publication number: 20030113362
    Abstract: A biochemical compound is described comprising ascorbic acid and at least one essential aminoacid, wherein the ascorbic acid is covalently bound to the aminoacid. The present invention provides a method of use of a biochemical compound where ascorbate molecules are covalently bound to essential amino acids, nonessential amino acids and amino acids that do not occur in protein to prevent oxidation.
    Type: Application
    Filed: August 23, 2002
    Publication date: June 19, 2003
    Inventors: Waheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
  • Publication number: 20020037923
    Abstract: The invention provides a resorcinol derivative and a method of using the resorcinol derivative to attenuate the growth of a neoplasm.
    Type: Application
    Filed: August 13, 2001
    Publication date: March 28, 2002
    Inventor: Craig R. Travis
  • Patent number: 6136832
    Abstract: The present invention relates to synthetic methods for the production of both optically active and racemic 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones; 5-[(4-aryl)-3-butynyl]-3,4-dihydroxy-2(5H)-furanones; 5-(2-arylthio)ethyl-3,4-dihydroxy-2(5H)-furanones; and 5-(2-aryloxy)ethyl-3,4-dihydroxy-2(5H)-furanones. This invention further relates to the use of the above mentioned compounds as anti-inflammatory agents through their action as mixed inhibitors of lipid peroxidation, 5-lipoxygenase, cyclooxygenase-1 and cyclooxygenase-2. The invention further relates to the use of such compounds in the treatment of chronic inflammatory disorders such as asthma, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, acute respiratory distress syndrome, and central nervous system disorders such as Alzheimer's and Parkinson's disease wherein reactive oxygen species and inflammatory mediators are contributing deleterious factors.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: October 24, 2000
    Assignee: Oxis International Inc.
    Inventors: Allen T. Hopper, John A. Ziemniak, Robert E. Johnson
  • Patent number: 5679801
    Abstract: There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R;Y is --O-- or --S--;R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof;which by virtue of their ability to inhibit PLA.sub.2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: October 21, 1997
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, James M. Rinker
  • Patent number: 5516919
    Abstract: Metal salts or substitutted or non-substituted ammonium salts of ascorbic acid derivatives can be produced in high yield by treating an acidic aqueous solution containing ascorbic acid-2-phosphate or ascorbic acid-2-sulfate with a porous adsorbent such as activated carbon, followed by treating the adsorbent with a basic aqueous solution containing e.g. a metal salt of an organic acid or substituted or non-substituted ammonium salt ion to elute the desired salt of ascorbic acid derivative.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: May 14, 1996
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Atsunori Sano, Kuniaki Okamoto, Jun Ebashi
  • Patent number: 5242945
    Abstract: There are disclosed compounds of the formula: ##STR1## wherein X is --CH.sub.2 R;R is ##STR2## and further when Y=S, R may also be --(CH.sub.2).sub.e CH.sub.3 ; Y is --O--or --S--;R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl;R.sup.3 is indolyl, furyl, phenyl or phenyl optionally mono- or disubstituted independently by alkyl of 1-7 carbon atoms, --C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3, --C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3, haloloweralkyl, perfluoroalkyl, lower alkoxy, aryl alkoxy, halo or nitro;R.sup.4 and R.sup.5 are, independently, --COCH.sub.2 R.sup.7, --CO.sub.2 R.sup.7, --CONHR.sup.7, geranyl or CH.sub.2 R.sup.3 ;R.sup.6 is hydrogen or lower alkyl;R.sup.7 is geranyl and any moiety selected from R other than ##STR3## A and B are, independently, --O--, --S-- or --NR.sup.6 --; and a is 0-8;b is 1-10 when Y=S, and 2-10 when Y=O;c is 1-3;d is 0-9; ande is 3-18;which by virtue of their ability to inhibit PLA.sub.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: September 7, 1993
    Assignee: American Home Products Corporation
    Inventors: Craig E. Caufield, James M. Rinker
  • Patent number: 5239087
    Abstract: The present invention relates to a process for the production of dipotassium-ascorbate-2-sulfate-dihydrate, a vitamin C derivative. It is used, among other things, as an additive to fish feed. In the process according to the process according to the invention, trimethylamine-sulfur-trioxide complex is added in only slight molar excess to a concentrated solution of potassium-L-ascorbate in water, and the pH value of this reaction mixture is set by successive additions of potassium hydroxide at a value in the range between 9.5 and 10.5, and is kept at this value for the duration of the reaction. The process permits the profitable production of dipotassium-ascorbate-2-sulfate-dihydrate on a large industrial scale. It is also explained how trimethylamine-sulfur-trioxide complex can be recovered from trimethylamine which occurs as a by-product during the production of dipotassium-ascorbate-2-sulfate.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: August 24, 1993
    Assignee: Enco Engineering Chur AG
    Inventors: Guberovic Zeljko, Marijan Hohnjec, Josip Kuftinec, Milan Oklobdzija
  • Patent number: 5189057
    Abstract: A compound of the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each is a hydrocarbon residue, R.sub.3 is a sulfo group or phosphono group, --CO--R.sub.4 is an esterified carboxyl group, a thiol-esterified carboxyl group or an amidated carboxyl group; and .about. represents the absolute configuration of R or S, or its salt, which is useful for preventing and treating thrombosis.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: February 23, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Koichi Kato, Hirotomo Masuya, Moriya Norihiko
  • Patent number: 4997958
    Abstract: A process for the manufacture of 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid by esterifying the ascorbic acid with an aliphatic C.sub.2-20 -carboxylic acid halide in the presence of a N,N-dialkyl-alkanecarboxylic acid amide, of a cyclic amide of the 1-methyl-2-pyrrolidone type, of a tetraalkylcarbamide such as tetramethylurea, of a cyclic carbamide of the 1,3-dimethyl-2-imidazolidinone type or of a phosphoric acid triamide of the hexamethylphosphoric acid triamide type. The 6-ascorbyl linolate which can be manufactured in this manner is novel and is likewise an object of the present invention. The thus-manufacturable 6-aliphatic C.sub.2-20 -carboxylic acid esters of ascorbic acid are important alternative application forms of L-ascorbic acid (vitamin C).
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: March 5, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Horst Pauling, Christof Wehrli
  • Patent number: 4876273
    Abstract: New polyether antibiotic A80577, its acyl ester and alkyl ether derivatives, and salts thereof, are useful antibacterial agents and increase feed-utilization efficiency in animals. Methods of making A80577 by culture of Actinomadura verrucosospora, NRRL 18236, and compositions containing an A80577 compound also are provided.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: October 24, 1989
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Raymond C. Yao
  • Patent number: 4822898
    Abstract: An ascorbic acid or erythorbic acid derivative represented by the following general formula: ##STR1## wherein n represents an integer of 4 to 20; and a process for producing said ascorbic acid or erythorbic acid derivative which comprises heat-treating 2,5,6-triacyl-substituted-ascorbic acid or -erythorbic acid represented by the following general formula: ##STR2## wherein n represents an integer of 4 to 20, in the presence of water and/or a lower aliphatic alcohol at a temperature of 30.degree. C. to 100.degree. C. and thereby selectively eliminating only the acyl group of the 2-position.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: April 18, 1989
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kazuo Kamaya, Yukihisa Takisawa
  • Patent number: 4727164
    Abstract: A solution of L-ascorbic acid and a solution of para amino benzoic acid are mixed and the mixture evaporated to permit recovery of a solid compound. The compound is administered to a host to reduce thrombotic tendencies.
    Type: Grant
    Filed: January 9, 1986
    Date of Patent: February 23, 1988
    Inventors: Philip N. Sawyer, Leon D. Freeman
  • Patent number: 4705869
    Abstract: Fatty acid esters of ascorbic acid are prepared by a process in which a homogeneous mixture of(a) ascorbic acid,(c) concentrated sulfuric acid having a concentration of not less than 96% and(c) a methyl or ethyl ester of a fatty acid of 12 to 18 carbon atomsis reacted at from 20.degree. to 50.degree. C.Using the novel process, the fatty acid esters of ascorbic acid, in particular ascorbyl palmitate, which are very desirable antioxidants are obtained by a procedure which is technically simpler and hence cheaper than the conventional processes, but in equally good yields.
    Type: Grant
    Filed: August 2, 1985
    Date of Patent: November 10, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Helmut Nickels, Alfred Hackenberger
  • Patent number: 4423236
    Abstract: Novel condensation products between enediol ketolactones such as 5,6-0-isopropylidene ascorbic acid and 2-chloroethyl isocyanates are shown to have potent antitumor activity probably without the release of alkylating agents in vivo. While the structures of the products are not readily elucidated, activity is found to exceed that of BCNU (bis-(2-chloroethyl)-N-nitrosourea) and parallel that of the toxic and highly effective nitrosourea, MeCCNU (1-(4-trans-methylcyclohexyl)-3-(2-chloroethyl)-3-nitrosourea). Preferred compounds are condensation products of ##STR1## wherein R.sub.2 and R.sub.3 are a lower alkyl group containing 1 to 3 carbon atoms or H andhal--CH.sub.2 --CH.sub.2 --N.dbd.C.dbd.O (B)wherein hal is I, Br or Cl.
    Type: Grant
    Filed: October 23, 1981
    Date of Patent: December 27, 1983
    Assignee: National Foundation for Cancer Research, Inc.
    Inventor: Andrew J. Welebir