Sulfur Or Oxygen Containing Patents (Class 568/13)
-
Patent number: 6576684Abstract: Disclosed are compositions from which radically initiated oligomers/polymers having a controlled molecular weight, low polydispersity and a vinyl or dienyl end group are prepared. Further subjects of the invention are a process for controlled radical polymerization, oligomers/polymers obtainable by said process and the use of specific addition fragmentation agents for the polymerization process. The addition fragmentation agents are new in part and these are also subject of the present invention. The addition fragmentation agents are of the formula (Ia), (Ib) or (Ic) where Y is a group which activates the double bond towards Michael addition.Type: GrantFiled: February 15, 2001Date of Patent: June 10, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Vincent Desobry, Peter Murer, Anne Schuwey
-
Patent number: 6573318Abstract: Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan.Type: GrantFiled: August 5, 1999Date of Patent: June 3, 2003Assignee: Rohm and Haas CompanyInventors: Tod C. Duvall, Paul B. Adams, Gene K. Norris
-
Publication number: 20030096189Abstract: Disclosed are novel onium salts represented by general formula (R) 3S+M, wherein three R's may be the same or different, each being an aryl group, provided that at least one of R's is a t-alkoxy substituted phenyl group, and M is an anion capable of foxing the sulfonium salts; and high energy radiation-responsive positive resist materials using said novel onium salts as acid generator.Type: ApplicationFiled: March 11, 1997Publication date: May 22, 2003Inventors: FUJIO YAGIHASHI, TOMOYOSHI FURIHATA, JUN WATANABE, AKINOBU TANAKA, YOSHIO KAWAI, TADAHITO MATSUA
-
Patent number: 6548707Abstract: Halogen-containing polymer compositions comprising a latent mercaptan-containing heat stabilizer composition substantially free from the offensive odor typically associated with mercaptans are protected during processing by the degradation products of the latent (i.e., blocked) mercaptan which include a free mercaptan. Other products of the degradation are believed to include carbocations of the blocking moiety which are stabilized by a molecular structure in which the electron deficiency is shared by several groups. The latent mercaptan may be the sole heat stabilizer additive but the free mercaptan released during processing may also synergize the activity of metal-based heat stabilizers such as metal salts and organometallic stabilizers such as organotin carboxylates and mercaptides in the polymer composition. The odor of primary mercaptan-containing heat stabilizers in halogenated polymer compositions is masked by a small amount of a latent mercaptan.Type: GrantFiled: August 4, 1999Date of Patent: April 15, 2003Assignee: Rohm and Haas CompanyInventors: Tod C. Duvall, Paul B. Adams, Gene K. Norris
-
Patent number: 6548708Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P—M, R2P—L and R3P, and the novel cation R2P+(L)—X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P—L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P—L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: GrantFiled: February 2, 2001Date of Patent: April 15, 2003Assignee: SRI InternationalInventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Wolf Eilenberg
-
Publication number: 20030009046Abstract: A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia 1Type: ApplicationFiled: July 22, 2002Publication date: January 9, 2003Inventors: Carsten Bingel, Markus Goeres, Volker Fraaije, Andreas Winter
-
Patent number: 6462200Abstract: The invention relates to the preparation and use as catalysts of diphosphines of the formula (I) in which R is C6-C14-aryl or C4-C13-heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the aryl and heteroaryl radicals may optionally be substituted by halogen, C1-C6-alkyl, C1-C6-alkoxy, and/or trimethylsilyl, and R1 to R4, independently of one another, are each hydrogen, C1-C10-alkyl, C1-C10-alkoxy, F, Cl, or Br.Type: GrantFiled: September 7, 2001Date of Patent: October 8, 2002Assignee: Bayer AktiengesellschaftInventors: Birgit Driessen-Hölscher, Joachim Kralik, Inga Ritzkopf, Christian Steffens, Guido Giffels, Claus Dreisbach, Thomas Prinz, Walter Lange
-
Publication number: 20020086920Abstract: Flexible and semi-rigid vinyl chloride resin compositions comprising a combination of a latent mercaptan and a zinc salt of oxidized polyethylene (a zinc ionomer) as a heat stabilizer are substantially free from the offensive odor typically associated with mercaptans and are protected during processing by the degradation products of the latent mercaptan and the zinc ionomer. The oxidized polyethylene is split out from the ionomer to act as an adhesion promoter for aqueous inks and paints, and the residual zinc carboxylate functions as a co-stabilizer with the latent mercaptan in the composition. The latent mercaptan is exemplified by a 2-S-(tetrahydropyranyl)thioalkanol, a carboxylic acid ester thereof, a 2-S-(tetrahydropyranyl)thiocarboxylic acid, an ester thereof, and the furanyl homologs of each.Type: ApplicationFiled: May 26, 1999Publication date: July 4, 2002Inventors: TOD C. DUVALL, JEFFREY L. CARPENTER
-
Publication number: 20020087030Abstract: A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second aromatic in a palladium-catalyzed cross-coupling reaction to give a biaryl and converting the ester or benzylic OH groups into polymerizable groups in one or more steps. The biaryls obtained are suitable for preparing polymers which are used as electroluminescence materials.Type: ApplicationFiled: October 16, 2001Publication date: July 4, 2002Inventors: Hubert Spreitzer, Willi Kreuder, Heinrich Becker, Jochen Krause
-
Publication number: 20020072637Abstract: A single-stage method for producing &agr;-hydroxy ethers by oxidizing olefinic substrates with organic hydroperoxides and opening the resultant oxirane ring by means of monovalent or polyvalent alcohols wherein a molybdenum compound in combination with a compound selected from the group consisting of boron trifluoride, aluminum oxides, 1,8-diazabicyclo-[5.4.0]-undec-7-ene or 1,4-diazabicyclo-[2.2.2]-octane, and mixtures thereof is used as a catalyst system.Type: ApplicationFiled: November 8, 2001Publication date: June 13, 2002Inventors: Mark Rusch gen. Klaas, Siegfried Warwel, Hans-Martin Zillmann, Klaus Kwetkat
-
Patent number: 6395916Abstract: One aspect of the present invention relates to novel, electron-rich bidentate ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.Type: GrantFiled: July 10, 1998Date of Patent: May 28, 2002Assignee: Massachusetts Institute of TechnologyInventors: Stephen L. Buchwald, John P. Wolfe, David W. Old, Ken Kamikawa, Michael Palucki
-
Publication number: 20020058837Abstract: A novel 2,2-(diaryl)vinylphosphine compound represented by the following general formula (1): 1Type: ApplicationFiled: June 27, 2001Publication date: May 16, 2002Inventors: Ken Suzuki, Tohru Kobayashi, Takenobu Nishikawa, Yoji Hori, Toshimitsu Hagiwara
-
Publication number: 20020055584Abstract: A method of preparing a sterile article is disclosed. A polymer having a halogen-containing repeating unit is prepared that contains about 0.Type: ApplicationFiled: October 9, 2001Publication date: May 9, 2002Applicant: Occidental Chemical CorporationInventors: Qi Wang, Sandor Nagy
-
Patent number: 6380277Abstract: The present invention relates to iodonium salts containing urethane groups of reduced crystallization tendency, to a process for their preparation, and to their use for the radiation curing of cationically curing compositions.Type: GrantFiled: September 19, 2000Date of Patent: April 30, 2002Assignee: Goldschmidt AGInventors: Sascha Oestreich, Andreas Weier, Stefanie Volkmer
-
Patent number: 6350910Abstract: The present invention describes a method for stereospecific isomerisation of prochiral allylamines into enamines and chiral imines, by using catalysts of Rh, Ir and Ru having phosphine chiral ligands immobilised on a solid material. The immobilised ligands are derivatives of phosphines of the type bis(diphenylphosphino)biaryl such as, for example, the phosphine known by the name BINAP. The method is particularly suitable for the production of optically active citronellal which may be obtained in optical purities above 95%.Type: GrantFiled: June 7, 2000Date of Patent: February 26, 2002Assignee: Firmenich SAInventor: Christian Chapuis
-
Patent number: 6348184Abstract: Novel radiopharmaceutical compositions comprising, in combination with a pharmaceutically acceptable carrier, a radioactive salt of pyrophosphoric acid. Also provided are novel radiopharmaceutical compositions comprising, in combination with one or more polymeric resins, a radioactive salt of pyrophosphoric acid. The compositions and matrices are suitable, inter alia, for use in treatment methods involving brachytherapy.Type: GrantFiled: October 18, 2000Date of Patent: February 19, 2002Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Jorge Osvaldo Nicolini, Ricardo Julio Ughetti
-
Publication number: 20020012631Abstract: This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly functionalized phosphine ligated 99mTc labeled HYNIC-conjugated biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.Type: ApplicationFiled: April 5, 2001Publication date: January 31, 2002Inventor: Shuang Liu
-
Patent number: 6339103Abstract: The new compound, dimethy[3-(propoxycarbonylamino)propyl]ammonium O-ethylphosphonate, having fungicidal activity, its preparation, compositions comprising it and methods for its use in agriculture.Type: GrantFiled: December 12, 2000Date of Patent: January 15, 2002Assignee: Aventis CropScience UK LimitedInventors: Norman John De'Ath, John Klostermyer, Albert Schirring, Michael Alan Webb, Geoffrey Gower Briggs
-
Publication number: 20010031898Abstract: 1Type: ApplicationFiled: February 5, 2001Publication date: October 18, 2001Inventors: Jean-Pierre Wolf, Beat Michael Aebli, Gebhard Hug
-
Patent number: 6281390Abstract: Compounds of formula III, wherein R6 und R7 signify identical or different secondary phosphino; R8 is —CH2—OH, —CH2—NH2—, —CH2O——B—FU, —CH2—NH2—B—FU, or —O—B—FU; R9 has the same significance as R8 or is C1-C4-alkyl or C1-C4-alkoxy; or R8 and R9 together signify HOCH(CH2—O—)2, H2NCH—(CH2—O—)2, FU—B—OCH(CH2—O—)2 or FU—B—HNCH(CH2—O—)2; B is a bridging group; and FU is a functional group. The compounds may be bonded to inorganic or organic carriers. Their d-8 metal complexes are valuable catalysts for the enantioselective hydrogenation of prochiral organic compounds with carbon multiple bonds or carbon/hetero atom multiple bonds.Type: GrantFiled: November 17, 1999Date of Patent: August 28, 2001Assignee: Solvias AGInventors: Benoît Pugin, Ivo Steiner, Rhony Niklaus Aufdenblatten, Antonio Togni
-
Patent number: 6225487Abstract: A new ligand having a backbone comprised of PCCC, where the last carbon atom is sp3 hybridized can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including C—N bond formation.Type: GrantFiled: April 17, 1998Date of Patent: May 1, 2001Assignee: Symyx Technologies, Inc.Inventor: Anil Guram
-
Patent number: 6211397Abstract: A process for the preparation of &agr;-chloromethylene-triorganylphosphorane derivatives I (radicals R are C-organic substituents and A stands for CN or CO-B where B is a C-organic or O-organic radical which is inert under chlorination conditions) by chlorination of phosphoranes II with chlorine, wherein the chlorination is carried out in the presence of a mineral base as hydrogen chloride acceptor and the chlorine and base are fed to the reaction mixture concurrently but separately at the rates at which they are consumed. The reaction products I are important intermediates for plant protectants.Type: GrantFiled: March 2, 1994Date of Patent: April 3, 2001Assignee: BASF AktiengesellschaftInventors: Bernd Schaefer, Ernst Buschmann, Gernot Reissenweber
-
Patent number: 6169179Abstract: A method for manufacturing (3S,4R)-4-[(R)-1′-formylethyl]azetidin-2-one derivatives represented by formula (3) wherein R1 represents a hydrogen atom or a protective group, through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1) wherein R1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2) wherein R2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom. By use of both an inexpensive optically active diphosphine compound and a rhodium complex as catalysts, intermediate compounds important for carbapenem antibiotics can be manufactured with high selectivity and efficiency.Type: GrantFiled: June 10, 1999Date of Patent: January 2, 2001Assignee: Takasago International CorporationInventors: Howard Alper, Takao Saito, Takashi Miura
-
Patent number: 6166234Abstract: Novel tripodal cyclopentadiene derivatives have the formula (I) ##STR1## where E are identical or different and are --N(R)(R), --P(R)(R), --As(R)(R), --Sb(R)(R), --OR, --SR, --SeR, --TeR, where R are identical or different and are each hydrogen, a C.sub.1 -C.sub.20 -carboorganic radical or a C.sub.1 -C.sub.30 -organosilicon radical, or E is a leaving group X andR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 are identical or different and are each hydrogen, a C.sub.1 -C.sub.20 -carboorganic radical or a C.sub.1 -C.sub.30 -organosilicon radical,Z is a cyclopentadienyl radical or a substituted cyclopentadienyl structural unit andT is hydrogen, a C.sub.1 -C.sub.20 -carboorganic radical or a C.sub.1 -C.sub.30 -organosilicon radical or a group E--Y--, where E is --N(R)(R), --P(R)(R), --As(R)(R), --Sb(R)(R), --OR, --SR, --SeR, --TeR or a leaving group X, where R are identical or different and are each hydrogen, a C.sub.1 -C.sub.20 -carboorganic radical or a C.sub.1 -C.sub.Type: GrantFiled: January 13, 1998Date of Patent: December 26, 2000Assignee: BASF AktiengesellschaftInventors: Gottfried Huttner, Joachim Vogelgesang, Ute Winterhalter, Bjorn Antelmann
-
Patent number: 6162951Abstract: Compounds of Formula (I) wherein R, R.sup.1, R.sup.2 and R.sup.9 are as herein defined, processes for their preparation and transition metal complexes comprising such compounds are disclosed. The complexes may be attached to insoluble supports and are useful as asymetric catalysts.Type: GrantFiled: March 19, 1999Date of Patent: December 19, 2000Assignee: Oxford Asymmetry International plcInventors: Mario Eugenio Cosamino Polywka, Edwin Moses, Daniel John Bayston, Anthony David Baxter, Mark Richard Ashton
-
Patent number: 6160180Abstract: A compound is disclosed having the formula (I), in which m equals 1 to 1000; x equals 0 to 4; W is a group of formulas --CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)CH.sub.2 -- or --CH.sub.2 CH(CH.sub.3)--; R is hydrogen, a straight-chain or branched-chain C.sub.1 -C.sub.5 alkyl radical; or a group of formulas (a) or (b), in which a, b, c, d and e independently represent a number from 0 to 1000, at least one of the numbers represented by a, b, c, d and e being higher than 0; R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.5 alkyl or a group of formula (c); R.sup.1 and R.sup.2 are the same or different and represent a straight-chain, a branched-chain or a cyclic C.sub.1 -C.sub.30 alkyl radical or C.sub.6 -C.sub.10 aryl radical which is non-substituted or substituted by one to five C.sub.1 -C.sub.3 alkyl radicals, or R.sup.1 and R.sup.Type: GrantFiled: April 22, 1999Date of Patent: December 12, 2000Assignee: Celanese Chemicals Europe GmbHInventors: Steffen Haber, Hans-Jerg Kleiner, Sandra Bogdanovic, Helmut Bahrmann, Carl-Dieter Frohning
-
Patent number: 6140310Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.Type: GrantFiled: May 6, 1998Date of Patent: October 31, 2000Assignee: Drug Innovation & Design, Inc.Inventor: Arnold Glazier
-
Patent number: 6124476Abstract: The present invention discloses new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds. The invention also relates to the field of catalysis. In particular, this invention relates to new compounds which when combined with suitable metals or metal precursor compounds provide useful catalysts for various bond-forming reactions, including Suzuki cross-coupling reactions. The invention also relates to performing Suzuki cross coupling reactions with unreactive aryl-chlorides.Type: GrantFiled: February 18, 1999Date of Patent: September 26, 2000Assignee: Symyx Technologies, Inc.Inventors: Anil Guram, Xiaohong Bei, Timothy S. Powers, Bernd Jandeleit, Thomas Crevier
-
Patent number: 6037500Abstract: The present invention relates to rigid chiral ligands usefull in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed into catalysts to provide high selectivity of the enantiomeric structure of the end-product.Type: GrantFiled: June 13, 1997Date of Patent: March 14, 2000Assignee: The Penn State Research FoundationInventor: Xumu Zhang
-
Patent number: 6002029Abstract: Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.Type: GrantFiled: December 8, 1997Date of Patent: December 14, 1999Inventors: Karl Y. Hostetler, Ganesh D. Kini
-
Patent number: 5932770Abstract: A process for separating off phosphine oxides and alkylarylphosphines from an organic reaction mixture of a homogeneous hydroformylation carried out with the use of a catalyst system, which reaction mixture contains organometallic complex compounds and, in a molar excess, ammonium salts of aromatic phosphines as ligands comprising subjecting the organic reaction mixture to an extraction treatment with a 0.001-0.5% strength by weight of an alkali metal hydroxide or alkaline earth metal hydroxide solution and separating off the aqueous phase containing the phosphine oxides and alkylarylphosphines to decrease markedly the concentration of the phosphine oxides and alkylarylphosphines in the hydroformylation mixture, which process is particularly suitable for continuously operated hydroformylations.Type: GrantFiled: August 11, 1997Date of Patent: August 3, 1999Assignee: Hoechst AktiengesellschaftInventors: Helmut Bahrmann, Thomas Muller
-
Patent number: 5929273Abstract: The present invention provides novel water-soluble diphosphines having the formula ##STR1## wherein X, Y, R.sub.1-18 and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.Type: GrantFiled: April 18, 1996Date of Patent: July 27, 1999Assignee: Celanese International CorpInventors: Christian W. Kohlpaintner, Brian E. Hanson, Hao Ding
-
Patent number: 5925785Abstract: The invention relates to secondary and tertiary phosphines of the formula ##STR1## in which R is hydrogen, an aryl or benzyl group or a straight-chain or branched alkyl group, n is 1 or 2 and M is potassium or sodium.These phosphines are prepared by reacting either alkali metal salts of fluorobenzene-2,4-disulfonic acid with phosphine or with primary or secondary phosphines, or secondary phosphines of the type HP?C.sub.6 H.sub.3 -2,4-(SO.sub.3 M).sub.2 !.sub.2 with a compound RX in which R is an alkyl, aryl or benzyl group and X is a halogen, in an aprotic solvent in the presence of at least stoichiometric quantities of a solid, powdered alkali metal hydroxide at temperatures of from 0 to 100.degree. C.Type: GrantFiled: March 20, 1997Date of Patent: July 20, 1999Assignee: Celanese GmbHInventors: Othmar Stelzer, Oliver Herd, Norbert Weferling
-
Patent number: 5908931Abstract: The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: December 14, 1990Date of Patent: June 1, 1999Assignee: Mallinckrodt Inc.Inventors: Raghavan Rajagopalan, William L. Neumann, Dennis L. Nosco
-
Patent number: 5874628Abstract: The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. The general reaction scheme is shown below: ##STR1## wherein R.sup.1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; R.sup.2 and R.sup.3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CoNR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R.Type: GrantFiled: March 26, 1997Date of Patent: February 23, 1999Assignee: Monsanto CompanyInventors: Scott A. Laneman, David J. Ager, Amihia Eisenstadt
-
Patent number: 5856558Abstract: The present invention relates to novel stabilized phosphorous ylides and processes for their preparation. More particularly, the present invention relates to a process for substituting the carbonyl oxygen of 2-formyl- or 2-oxoalkylidenetriphenyl-phosphoranes (OATP) by other stabilizing groups to form novel compounds having an increased tendency to form complexes or compounds which absorb in the visible region of the spectrum.The compounds according to the present invention areCompounds of the formula (1)Ph.sub.3 .dbd.CH--C(R).dbd.Nu (1)wherein R is hydrogen, a C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.3 -fluoroalkyl or perfluoroalkyl radical, an unfluorinated or fluorinated C.sub.6 -C.sub.14 -aryl radical or a group OCH.sub.3 ; andNu is S, Se, C(CN).sub.2, NH, PhN, PhNHN, ##STR1## or a radical of the formulae (a), (b), (c), (d) or (e) ##STR2## wherein Z is C(CH.sub.3).sub.2, S or N(CH.sub.3) and n=1 or 2 (provided that the combinations R.dbd.Ar, SAlk or OAlk and Nu.dbd.NPh, and the combinations R.dbd.Type: GrantFiled: August 18, 1997Date of Patent: January 5, 1999Assignee: Hoechst AktiengesellschaftInventors: Sergej Pasenok, Wolfgang Appel
-
Patent number: 5834611Abstract: In a process for the telomerization of dienes with nucleophiles in a liquid two-phase system, use is made as catalysts of complexes comprising a transition metal as central atom and at least one tris-(hydroxyalkyl)-phosphine or -phosphine oxide as ligand. The use as catalysts of compounds comprising a transition metal as central atom and at least one tris-(hydroxy-C.sub.2 -C.sub.5 -alkyl)-phosphine or -phosphine oxide as ligand, new compounds of this type and aqueous solutions of such compounds are likewise described.Type: GrantFiled: June 19, 1997Date of Patent: November 10, 1998Assignee: Bayer AktiengesellschaftInventors: Birgit Driessen-Holscher, Wilhelm Keim, Thomas Prinz, Hans-Joachim Traenckner, Jorg-Dietrich Jentsch
-
Patent number: 5817848Abstract: The invention relates to a bidentate phosphine ligand, the phosphorus atoms of the phosphine being connected via a bridge group, the bridge group of the bidentate phosphine ligand consisting of an ortho-anellated annular system, comprising two aryl groups, which aryl groups are connected by two bridges, the first bridge consisting of an --O-- or an --S-- atom and the second bridge being a group that contains an oxygen, sulphur, nitrogen, silicon or carbon atom or a combination of these atoms, the two phosphorus atoms being connected to the two aryl groups of the bridge group at the ortho-position relative to the --O-- or --S-- atom of the first bridge.The invention also relates to the use of this bidentate phosphium ligand in a catalyst system comprising also a transition metal compound which is used in the following type of reactions: hydroformylation hydrogenation, hydrocyanation, polymerization, isomerisation, carboxylation, cross coupling and metathesis.Type: GrantFiled: November 6, 1996Date of Patent: October 6, 1998Assignee: DSM N.V.Inventors: Paulus C. J. Kamer, Mirko Kranenburg, Petrus W. N. M. van Leeuwen, Johannes G. de Vries
-
Patent number: 5789608Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.Type: GrantFiled: December 11, 1996Date of Patent: August 4, 1998Assignee: Drug Innovation and Design, Inc.Inventor: Arnold Glazier
-
Patent number: 5789609Abstract: Disclosed are an optically active diphosphine represented by formula: ##STR1## wherein R represents a lower alkyl group having 1 to 4 carbon atoms; Ar represents a phenyl group which may be substituted with a lower alkyl group having 1 to 4 carbon atoms and/or a lower alkoxy group having 1 to 4 carbon atoms, a transition metal complex containing the diphosphine as a ligand, and a process for producing an optically active .delta.-oxo-.alpha.-cyano ester using the transition metal complex as a catalyst.Type: GrantFiled: October 22, 1997Date of Patent: August 4, 1998Assignee: Takasago International CorporationInventors: Kyoko Tamao, Koji Inagaki, Noboru Sayo
-
Patent number: 5767276Abstract: A chiral ligand having the following structure: ##STR1## wherein AR is any aromatic and/or ring structure, and R is selected from the group consisting of aryl, oxygenated aryl, alkyl, oxygenated alkyl, AR, oxygenated AR and combinations thereof.Type: GrantFiled: October 11, 1996Date of Patent: June 16, 1998Assignee: The Penn State Research FoundationInventor: Xumu Zhang
-
Patent number: 5696277Abstract: Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.Type: GrantFiled: November 15, 1994Date of Patent: December 9, 1997Assignee: Karl Y. HostetlerInventors: Karl Y. Hostetler, Ganesh D. Kini
-
Patent number: 5693868Abstract: The present invention provides a method for producing novel optically active diphosphine compounds ?2,2'-bis(di-substituted phosphino)-1,1'-binaphthyl compounds! having a selectivity (chemoselectivity or enantioselectivity) and catalytic activity different from those of conventional BINAP compounds. In a method of the present invention for producing an optically active diphosphine compound (i.e., 2,2-bis(di-substituted phosphino)-1,1'-binaphthyl), 2,2'-bis(trifluoromethanesulfonyloxy)-1,1'-binaphthyl is reacted, in the presence of a transition metal-phosphine complex, with a phosphineoxide compound represented by the following general formula:A.sub.Type: GrantFiled: October 30, 1996Date of Patent: December 2, 1997Assignee: Takasago International CorporationInventors: Noboru Sayo, Xiaoyong Zhang, Tatsuya Ohmoto, Akifumi Yoshida, Tohru Yokozawa
-
Patent number: 5684181Abstract: The sulfonation of arylphosphines, which contain at least one aromatic radical which can be sulfonated, is carried out with an anhydrous mixture of sulfuric acid and orthoboric acid. By choosing the appropriate reaction temperature, the process allows selective introduction of the desired number of sulfonic acid radicals into the phosphine molecule and avoids the formation of phosphine oxides. When separating the sulfonation mixture, the orthoboric acid can be separated off together with the sulfuric acid.Type: GrantFiled: October 2, 1995Date of Patent: November 4, 1997Assignee: Hoechst AktiengesellschaftInventors: Guido Albanese, Rainer Manetsberger, Wolfgang A. Herrmann, Christine Schwer
-
Patent number: 5627165Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.Type: GrantFiled: September 23, 1994Date of Patent: May 6, 1997Assignee: Drug Innovation & Design, Inc.Inventor: Arnold Glazier
-
Patent number: 5623089Abstract: Novel triphenylbis(fluoroalkoxy)phosphoranes and a process for their preparation are disclosed. Also disclosed is a process for making fluorinated ketals by reacting phosphoranes with fluorinated ketones.Type: GrantFiled: May 22, 1995Date of Patent: April 22, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventor: Zhen-Yu Yang
-
Patent number: 5616785Abstract: Hydroformylation of alkenes to aldehydes in the presence of a rhodium complex catalyst is improved by the addition of a novel bidentate ligand of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.1.sup.' are organic radicals selected from alicyclic, aliphatic and aromatic groups of which at least one is preferably substituted with at least one electronegative moiety and the methylene groups are present at the trans-2,3 positions on the norbornane moiety. The invention also provides a novel method for producing the bidentate ligand and novel intermediate phosphine oxide and phosphinous acid compounds.Type: GrantFiled: April 10, 1996Date of Patent: April 1, 1997Assignee: Hoechst Celanese CorporationInventors: Jerry D. Unruh, Brigitte E. Segmuller, Gabriel R. Chapa, Kent E. Pryor
-
Patent number: 5576461Abstract: The present invention provides a process for preparing a sulphoxonium salt from the corresponding sulphonium salt which comprises oxidising the sulphonium salt using a peracid, under basic conditions, in a solvent other than a ketone.Some of the sulphoxonium salts are new compounds.Type: GrantFiled: December 6, 1990Date of Patent: November 19, 1996Assignee: Ciba-Geigy CorporationInventors: Edward Irving, Robert J. Lunn, David A. Taylor, Alan H. Haines, John P. Innocenzi
-
Patent number: 5554795Abstract: In accordance with the present invention there is provided a cyclopentadienyl-type ligand represented by the formula ZA, wherein Z is a cyclopentadienyl-type group, wherein A is --YPR.sub.2, --YNR.sub.2, or --NR.sub.2, wherein Y is an alkylene group containing 1 to 24 carbon atoms, wherein each R is individually selected from alkyl groups containing 1 to 20 carbon atoms. Another aspect of the invention is to provide a metallocene represented by the formula ZAMX.sub.3, wherein Z and A are as described above, M is a Group IVB or VB transition metal, and X is a halide. Other aspects of the present invention include catalyst systems comprising the metallocenes and an organoaluminoxane, processes for preparing the above defined ligands, metallocenes and catalyst systems, and polymerization processes employing the catalyst systems.Type: GrantFiled: May 19, 1995Date of Patent: September 10, 1996Assignee: Phillips Petroleum CompanyInventors: Krisztina Frey, Gabriele von Massow, Helmut G. Alt, M. Bruce Welch
-
Patent number: 5534557Abstract: The composition of the present invention is excellent in compatibility, transparency and curability and give a cured coat of excellent gloss and of less smell, and cured products of excellent properties can be obtained by curing the composition.The present invention relates to an onium salt represented by the following formula (1): ##STR1## wherein Ar is a mono- to tetra-valent aromatic group, X is a bisphenylsulfonio group which may have a substituent, a is 1-4, b is 0 or 1-3, a+b is 1-4, n is 1-4, and Z is a halide represented by the following formula (3): ##STR2## where M is a boron atom, a phosphorus atom, an arsenic atom or an antimony atom, Q is a halogen atom, m is 3-6, l is 0 or 1, and m+l is 4-6; a photopolymerization initiator containing the onium salt as an active ingredient; an energy ray-curable composition containing the initiator; and a cured product.Type: GrantFiled: June 2, 1995Date of Patent: July 9, 1996Assignee: Nippon Kayaku Kabushiki KaishaInventors: Tetsuya Abe, Kazuhiko Ishii, Minoru Yokoshima