Acyclic Patents (Class 568/382)
  • Publication number: 20150111811
    Abstract: Branched optionally unsaturated ketones particularly useful in providing typical and characteristic orris facets to perfume compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 23, 2015
    Inventor: Philip Kraft
  • Publication number: 20140249321
    Abstract: The present invention relates in a first aspect to a process for hydrogenation of ketones having at least a carbon-carbon double bond in the y,8-position to the keto group by hydrogen in the presence of at least one chiral iridium complex of formula (I), where R1 represents a group of formula (II) or (III) or (IV). It has been shown that this process leads to a strong increase in preferential formation of a single isomer. The process is particularly suitable for the hydrogenation of y,8-unsaturated ketones which can be used as flavours and fragrances or for the preparation of vitamin E and its derivatives or of flavours and fragrances.
    Type: Application
    Filed: June 13, 2012
    Publication date: September 4, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Marc-André Mueller, Andreas Pfaltz, Jonathan Medlock
  • Publication number: 20140128583
    Abstract: Disclosed is an anti-infective drug-macrolide derivate, preparation and uses thereof. Macrolide derivate, namely erythromycin ethylsuccinate crystalline hydrate, which has less moisture absorption and good storage stability, can be used in the preparation of medicaments for the treatment and prevention of human or animal infectious diseases caused by Gram-positive or negative bacteria.
    Type: Application
    Filed: April 20, 2012
    Publication date: May 8, 2014
    Inventor: Li Liu
  • Publication number: 20140107219
    Abstract: In one aspect, there is provided heptanone (e.g. 2-, 3- or 4-heptanone) or a salt thereof for use as a local anaesthetic. In another aspect, there is provided a pharmaceutical composition comprising heptanone (e.g. 2-, 3- or 4-heptanone) or a salt thereof and one or more pharmaceutically acceptable carriers, excipients or diluents. Also provided is use of heptanone (e.g. 2-, 3- or 4-heptanone) or a salt thereof in the preparation of a medicament for use as a local anaesthetic. Further provided is a method of treating a mammalian subject in need of local anaesthesia, comprising administering a pharmaceutical composition comprising heptanone (e.g. 2-, 3- or 4-heptanone) or a salt thereof in an effective amount to a region of the subject in need of local anaesthesia.
    Type: Application
    Filed: January 26, 2012
    Publication date: April 17, 2014
    Applicant: VITA (EUROPE) LIMITED
    Inventors: Max Watkins, George Theophilidis, Alexandros Papachristoforou
  • Publication number: 20140086879
    Abstract: Disclosed herein is an isolated Muscodor albus strain producing volatile organic compounds such as aristolene, 3-octanone and/or acetic acid ester, as well as cultures of said strain and compositions, metabolites and volatiles derived from said strain or culture as well as methods of obtaining said compositions, metabolites and volatiles and their methods of use for controlling pests. Also disclosed are artificial compositions having the same components and uses as the volatiles derived from the strain. A method for capturing and sampling the volatiles is also disclosed.
    Type: Application
    Filed: September 23, 2013
    Publication date: March 27, 2014
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Gary Strobel, Vu Phong Bui, Hai Su, Phyllis Himmel, Pamela Marrone, Lijuan Xing, Sarah Lewis
  • Publication number: 20140087475
    Abstract: Disclosed herein is a method for identifying compounds contributing to a sour odor emitting from an air conditioner, a method for artificially reproducing the detected sour odor and preparing a corresponding sour odor composition. Through the analysis method of the present invention, the compounds contributing to the sour odor emitted from an air conditioner may be identified and quantified. The detected sour odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sour odor may provide meaningful data required for development of an apparatus and a method for removing specific odors.
    Type: Application
    Filed: December 4, 2012
    Publication date: March 27, 2014
    Applicant: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Publication number: 20140051872
    Abstract: The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 20, 2014
    Applicant: Virent, Inc.
    Inventors: Brian Blank, Randy Cortright, Taylor Beck, Elizabeth Woods, Mike Jehring
  • Publication number: 20130298453
    Abstract: A process for the manufacture of butanol, acetone and/or other renewable chemicals is provided wherein the process utilises one or more of the group comprising by-products of the manufacture of malt whisky, such as pot ale and/or spent lees, biomass substrates, such as paper, sludge from paper manufacture and spent grains from distillers and brewers, and diluents, such as water and spent liquid from other fermentations. The process comprises treating a substrate to hydrolyse it and fermenting the treated. Also provided is a biofuel comprising butanol manufactured according to the process of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: November 14, 2013
    Inventors: Jane Samantha White, Kenneth Alexander Leiper, Martin Tangney, Sandra Messenger
  • Publication number: 20130244267
    Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.
    Type: Application
    Filed: September 6, 2012
    Publication date: September 19, 2013
    Inventors: Ellen May Sletten, Carolyn Ruth Bertozzi
  • Patent number: 8535689
    Abstract: A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: September 17, 2013
    Assignee: The Trustees of Princeton University
    Inventors: Bonnie Bassler, Martin Semmelhack, Douglas A. Higgins, Megan Eileen Bolitho, Kristina M. Kraml, Wai-Leung Ng
  • Publication number: 20130219776
    Abstract: A process for the manufacture of butanol, acetone and/or other renewable chemicals is provided wherein the process utilises one or more of the group comprising by-products of the manufacture of malt whisky, such as draff, pot ale and/or spent lees, biomass substrates, such as paper, sludge from paper manufacture and spent grains from distillers and brewers, and diluents, such as water and spent liquid from other fermentations. The process comprises treating a substrate to hydrolyse it and fermenting the treated substrate at an initial pH in the range of 5.0 to 6.0. Also provided is a biofuel comprising butanol manufactured according to the process of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: August 29, 2013
    Inventors: Jane Samantha White, Kenneth Alexander Leiper, Martin Tangney, Sandra Messenger
  • Publication number: 20130211143
    Abstract: The present invention relates to a cell retaining matrix (CRB) for producing solvents and alcohols and an apparatus comprising said bio-column. The invention also relates to the method for producing solvents and alcohols by using said cell retaining matrix (CRB). Said cell retaining biomatrix (CRB cellulosic fibers, selected from the group consisting wood cellulosic fibers, pulp cellulosic fibers, vegetable cellulosic fibers, such as mechanical pulp, dissolving pulp, lignocellulosic fibers, and cellulosic fibers originated from vegetable peels, and at microbes, which have been immobilized into said cellulosic fibers, and which can save their biological activity in cell retaining biomatrix (CRB).
    Type: Application
    Filed: July 8, 2011
    Publication date: August 15, 2013
    Applicant: AALTO UNIVERSITY FOUNDATION
    Inventor: Tom Granstrom
  • Publication number: 20130196155
    Abstract: A method for surface treating a carbon-containing material in which carbon-containing material is reacted with decomposing ozone in a reactor (e.g., a hollow tube reactor), wherein a concentration of ozone is maintained throughout the reactor by appropriate selection of at least processing temperature, gas stream flow rate, reactor dimensions, ozone concentration entering the reactor, and position of one or more ozone inlets (ports) in the reactor, wherein the method produces a surface-oxidized carbon or carbon-containing material, preferably having a surface atomic oxygen content of at least 15%. The resulting surface-oxidized carbon material and solid composites made therefrom are also described.
    Type: Application
    Filed: February 1, 2012
    Publication date: August 1, 2013
    Applicant: UT-Battelle, LLC
    Inventors: Felix Leonard Paulauskas, Soydan Ozcan, Amit K. Naskar
  • Publication number: 20130101544
    Abstract: The present invention provides a novel compound for counteracting amine-based malodor in consumer, industrial and textile products.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 25, 2013
    Inventors: Johan Gerwin Lodewijk Pluyter, Takashi Sasaki, Xiao Huang
  • Patent number: 8367078
    Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: February 5, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Peter P. Sayeski, György M. Keserü
  • Patent number: 8211664
    Abstract: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 3, 2012
    Assignee: The Regents of the University of California
    Inventors: Yi Tang, Xinkai Xie
  • Patent number: 8188245
    Abstract: This disclosure describes the molecular cloning of an enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, and characterization of individual genes in the gene cluster and the proteins encoded thereby. An enduracidin gene cluster is located within a 116 kilobases genetic locus and includes 25 open reading frames (ORFs). An additional 23 ORFs flank the disclosed enduracidin biosynthetic gene cluster. Enduracidin analogs and a method for producing them by manipulation of the enduracidin gene cluster and specific genes therein are also disclosed.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: May 29, 2012
    Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Xihou Yin, T. Mark Zabriskie
  • Publication number: 20120101304
    Abstract: The invention relates to cells and a method for producing acetone.
    Type: Application
    Filed: February 23, 2010
    Publication date: April 26, 2012
    Applicant: Evonik Degussa GmbH
    Inventors: Franz Ulrich Becker, Gerda Grund, Matthias Orschel, Kai Doderer, Gerd Löhden, Gerd Brand, Peter Dürre, Simone Thum, Hubert Johannes Bahl, Ralf-Jörg Fischer, Antje May
  • Patent number: 8143035
    Abstract: The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary metabolites, such as polyketides.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: March 27, 2012
    Assignee: Rice University
    Inventors: Hei Chan Lee, Jae Kyung Sohng, Ka-Yiu San
  • Publication number: 20120011918
    Abstract: The invention application presents a fast, efficient, reproductive alternative of a non-invasive method for diagnosing the severity of heart failure based on a specific biomarker. An additional object of the present invention is a collector device for the biomarker from exhaled breath that is portable, simple, low cost and does not need to run on electric power. This invention advantageously permits the replacement of invasive diagnosis methods, favoring the patient's comfort in addition to the agility and speed of medical attention at hospitals, and may become a standard method for all suspected cases of circulatory disease and heart failure and, more specifically, decompensated heart failure.
    Type: Application
    Filed: July 16, 2010
    Publication date: January 19, 2012
    Inventors: Fernando Bacal, Fabiana Goulart Marcondes Braga, Ivano Gebhardt Rolf Gutz, Guilherme Lopes Batista
  • Publication number: 20110293553
    Abstract: Compounds, compositions, kits, devices, and methods of attracting, detecting, eradicating, controlling, or killing an insect, such as a bed bug, by utilizing insect attractant, arresting, and/or aggregation compounds and compositions is provided. Insect attractant, arresting, and/or aggregation compounds identified from insect fecal extract by an analytical technique, such as gas chromatography, nuclear magnetic resonance (NMR), Carbon-13 NMR, mass spectroscopy, LC-MS, GC-MS, high performance liquid chromatography (HPLC), or combinations thereof are provided. A bed bug attractant, arresting, and/or aggregation compound identified from bed bug feces and exhibiting a Carbon-13 NMR peak at about ? 159.453 ppm is also provided.
    Type: Application
    Filed: May 28, 2010
    Publication date: December 1, 2011
    Inventors: Tai-Teh Wu, Kenneth Haynes, Joe Harold Hope, III
  • Publication number: 20110262970
    Abstract: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing a cationic polysaccharide to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of a first hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product. The cationic polysaccharide may be a cationic starch.
    Type: Application
    Filed: September 30, 2009
    Publication date: October 27, 2011
    Applicant: Novozymes North America, Inc.
    Inventors: Xin Li, Ye Chen, Jing Luo, Lindsay Jones
  • Publication number: 20110218365
    Abstract: Compositions and methods are provided for enhanced expression of light emitting reporters. Such reporters are used in methods for monitoring cultures for production of target compounds. Additionally, methods are provided for the use of light emitting reporter systems and other reporter systems for selecting desired traits in an organism and for identifying or optimizing culture conditions.
    Type: Application
    Filed: March 11, 2009
    Publication date: September 8, 2011
    Applicant: COBALT TECHNOLOGIES, INC.
    Inventors: Stacy M. Burns-Guydish, Pamela Reilly Contag
  • Publication number: 20110136723
    Abstract: A compound of the general formula X-[Q-W—(CH?CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L represents a leaving group; and m represent an integer of from 1 to 8. The compounds find use in the conjugation of biological molecules.
    Type: Application
    Filed: July 17, 2009
    Publication date: June 9, 2011
    Applicant: POLYTHERICS LIMITED
    Inventor: Antony Godwin
  • Publication number: 20100273890
    Abstract: A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
    Type: Application
    Filed: October 1, 2008
    Publication date: October 28, 2010
    Inventors: Bonnie L. Bassler, Martin Semmelhack, Douglas A. Higgins, Megan A. Pomianek, Kristina M. Kraml, Wai-Leung Ng
  • Publication number: 20100226949
    Abstract: The disclosure provides compounds useful as insect repellents and compositions comprising such repellents. The disclosure further provides insect traps.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 9, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Anandasankar Ray, Stephanie Lynn Turner
  • Publication number: 20100137647
    Abstract: Methods are disclosed for forming heptan-4-one, and, optionally, heptan-4-ol, from fermentable sugars. The sugars are fermented using a bacteria or yeast that predominantly forms butyric acid. The butyric acid is subjected to catalytic ketonization conditions to form heptan-4-one, with concomitant loss of water and carbon dioxide. The heptan-4-one can be subjected to catalytic hydrogenation to form heptan-4-ol, an either of these can be included in gasoline compositions. In one aspect, the fermentable sugars are derived from lignocellulosic materials such as wood products, switchgrass, or agricultural wastes, which are delignified to form lignin, cellulose and hemicellulose. The cellulose and hemicellulose can be depolymerized to form glycose and xylose, either or both of which can be fermented by the bacteria.
    Type: Application
    Filed: June 12, 2008
    Publication date: June 3, 2010
    Inventor: David Bradin
  • Publication number: 20090099384
    Abstract: The present invention provides a method of remedying deterioration of an insulating film which, during the remedial treatment of an insulating film deteriorated by plasma treatment, does not leave residual remedial agent on the wiring material such as the copper wiring layer, can be conducted using a dry process, and exhibits excellent applicability to mass production. The insulating film that has been deteriorated by plasma treatment is brought into contact with a remedial agent composed of a compound with a molecular structure having at least one of a nitro group and a carbonyl group, and at least one of a hydrocarbon group and a hydrogen group.
    Type: Application
    Filed: April 18, 2007
    Publication date: April 16, 2009
    Inventors: Shuji Nagano, Satoshi Hasaka, Minoru Inoue, Toshinori Shibata
  • Publication number: 20090053523
    Abstract: There is provided a method for efficiently manufacturing metal nano particles without condensing laser beams by using a lens etc. In this method, first, metallic foil pieces, which are a starting material, are dispersed in a dispersion liquid. Next, laser beams are irradiated directly to the metallic foil pieces without providing a condensing means, by which many metal fine particles are yielded. The particle diameters of the metal fine particles obtained can be controlled to sizes from nano particles to submicron particles by utilizing the relationship between the shape (especially thickness) of the metallic foil piece which is a starting material and the absorbed energy of the laser beam.
    Type: Application
    Filed: August 22, 2005
    Publication date: February 26, 2009
    Inventors: Mitsuo Kawasaki, Osamu Kajita, Ayu Onishi, Sachiko Masuoka, Takafumi Iwamoto, Eitaro Yasuda
  • Patent number: 7176177
    Abstract: 4,8-dimethyl-3,7-nonadien-2-one has aromatizing properties and increases the extendibility and intensity of the aroma when used in an aroma composition.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: February 13, 2007
    Assignee: Symrise GmbH & Co. KG
    Inventors: Stefan Lambrecht, Günter Kindel, Erich Dilk, Matthias Güntert
  • Patent number: 6603015
    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 5, 2003
    Assignee: University of Kansas
    Inventors: Gunda I. Georg, Sajiv K. Nair, Emily Reiff, Ashok Rao Tunoori
  • Patent number: 6376719
    Abstract: An alkaline earth metal salt of &bgr;-diketo compound is produced using 1 mol of a powdery alkaline earth metal compound and 2.04 mol or more of an aliphatic &bgr;-diketo compound. The reaction may be carried out while supplying both components to a reactor continuously or intermittently, or may be carried out by adding one component to the other continuously or intermittently. The highest temperature during the reaction may be at 50° C. or higher. The reaction mixture may be aged, and then dried at a temperature of at 100 to 180° C. in an atmosphere of an inert gas. The alkaline earth metal compound may be calcium hydroxide, magnesium hydroxide, or barium hydroxide. The aliphatic &bgr;-diketo compound may be represented by the following formula, particularly an acetoacetic acid ester or acetylacetone. According to the production method as mentioned above, highly stable alkaline earth metal salts of &bgr;-diketo compounds of high quality can be produced.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: April 23, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Masayuki Okada
  • Publication number: 20020010373
    Abstract: The invention relates to a process for purifying a crude 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate containing an impurity. The process includes bringing the crude 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate into contact with a poor solvent in which 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate is substantially insoluble, thereby removing the impurity from the crude 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate. Alternatively, the process includes precipitating crystals of 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate from a solution of the crude 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate. Thus, it is possible to produce 1,1,1,5,5,5-hexafluoroacetylacetone dihydrate of high purity. This product makes it easy to produce 1,1,1,5,5,5-hexafluoroacetylacetone of high purity.
    Type: Application
    Filed: December 21, 2000
    Publication date: January 24, 2002
    Inventors: Takeo Komata, Nariaki Ii, Yoshiki Hirotsu
  • Patent number: 6271408
    Abstract: This invention relates to trimethylsilyloxy-cyclopentane derivatives: 3-(1-Acetoxy-1-methylethyl)- 2-formyl-1-methyl-1-trimethylsilyloxy-cyclopentane; 4-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-buten-2-one; 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-1,4-dien-3-ol and alkyl 5-[5-(1-Hydroxy-1-methylethyl)-2-methyl-2-trimethylsilyloxy-cyclopentyl]-3-methyl-penta-2,4-dienoates.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: August 7, 2001
    Assignee: Roche Vitamins Inc.
    Inventors: Hanspeter Pfander, Bruno Traber
  • Patent number: 6201123
    Abstract: A catalyst composition for organic a symmetric synthesis is provided, which comprises: (A) a lanthanoid element ion; (B) a binaphthol, and (C) a nitrogen and/or phosphorus compound such as lutidine-N-oxide, 1,3-dimethyl-2-imidazolldinone, hexamethyl-phosphortriamide, triphenylphosphine oxide, tri(2-methylphenyl)phosphine oxide or tri(4-methylphenyl )phosphine oxide. Asymmetric epoxidation of an enone is conducted by allowing an enone to react with an oxidizing agent in the presence of the catalyst composition or a catalyst solution containing the catalyst composition.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: March 13, 2001
    Assignee: Techno Polymer Co., Ltd.
    Inventors: Kazuhiro Daikai, Masahiro Kamaura, Takeshi Hanamoto, Junji Inanaga
  • Patent number: 6156694
    Abstract: The present invention relates to a Raney catalyst comprising iron, cobalt, a third metal wherein the third metal is selected from the group consisting of nickel, rhodium, ruthenium, palladium, platinum, osmium, iridium and mixtures of any of the metals of this group.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: December 5, 2000
    Assignee: E. I. Dupont De Nemours & Company
    Inventor: Mark Jay Harper
  • Patent number: 6087296
    Abstract: The present invention relates to a Raney catalyst comprising iron, cobalt, a third metal wherein the third metal is selected from the group consisting of nickel, rhodium, ruthenium, palladium, platinum, osmium, iridium and mixtures of any of these metals.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: July 11, 2000
    Assignee: E. I. du Pont de Nemours & Co.
    Inventor: Mark Jay Harper
  • Patent number: 6069261
    Abstract: A process carried out in a reaction column for the chemical reaction of substances the reaction of which is affected by an unfavorable equilibrium position of the main reaction or a preceding equilibrium, wherein during the reaction one or more substances to be separated are continuously removed from the reaction mixture by one or more auxiliaries.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: May 30, 2000
    Assignee: RWE-DEA Aktiengesellschaft fur Mineraloel und Chemie
    Inventors: Ulrich Hoffmann, Ulrich Kunz
  • Patent number: 5936129
    Abstract: A process for making a sterically-hindered beta-diketone involving: (a) providing a solution comprising: (i) an ester; (ii) a base; and (iii) a solvent; (b) adding a ketone selected from the group consisting of an aromatic ketone and a hindered aliphatic ketone, to the solution, to form a condensation reaction mixture, whereby either the ester or the ketone is hindered; (c) reacting the solution with the ketone to form a sterically-hindered beta-diketone; and (d) recovering the sterically-hindered beta-diketone from the condensation reaction mixture.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: August 10, 1999
    Assignee: Henkel Corporation
    Inventors: Kevin V. Martin, Phillip L. Mattison, Michael J. Virnig
  • Patent number: 5914013
    Abstract: A process for selective thermal oxidation or photooxidation of hydrocarbons adsorbed onto zeolite matrices. A highly selective thermal oxidation and photooxidation of unsubstituted or alkyl substituted alkanes, alkenes, aromatics and cycloalkyls in solvent free zeolites under dark thermal conditions or under irradiation with visible light. The process oxidizes hydrocarbons almost completely selectively without substantial production of byproducts.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: June 22, 1999
    Assignee: The Regents of the University of California
    Inventors: Heinz Frei, Fritz Blatter, Hai Sun
  • Patent number: 5902896
    Abstract: A process for preparing bis(hydroxymethyl) compounds of the formula (I) ##STR1## wherein X.sup.1 and X.sup.2 represent identical or different electronegative groups, which process entails reacting C--H-acidic compounds of the formula (II) ##STR2## wherein X.sup.1 and X.sup.2 are as defined above, with formaldehyde, wherein the reaction is carried out in an anhydrous medium.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: May 11, 1999
    Assignee: Huels Aktiengesellschaft
    Inventor: Frank Bauer
  • Patent number: 5856537
    Abstract: Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding .alpha.-keto ethyl ester 8 (1.4 nM) and the trifluoromethyl ketone inhibitor 12 (1.2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: January 5, 1999
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Chi-Huey Wong, Dale L. Boger, Steven J. Henriksen
  • Patent number: 5786515
    Abstract: A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: July 28, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen
  • Patent number: 5723708
    Abstract: A method for producing cyclopentadienes which comprises the step of cyclodehydration of an unsaturated carbonyl compound having a specific chemical structure in a vapor phase in the presence of a specific solid acid catalyst. The cyclopentadienes of the invention can be produced in a high yield from inexpensive starting materials through a simplified reaction process and are useful as intermediate compounds for organic synthesis.
    Type: Grant
    Filed: September 27, 1995
    Date of Patent: March 3, 1998
    Assignee: Nippon Petrochemicals Company, Limited
    Inventors: Yasuo Matsumura, Kazuharu Suyama, Yoshihisa Inomata
  • Patent number: 5663450
    Abstract: This invention encompasses a substantially homogeneous lipid chemoattractant released from stressed mammalian tissue which is a neutral lipid which is acid labile and stable to base and is stable in boiling water. This lipid recruits macrophages but not neutrophils to stressed tissue. The invention also encompasses a method for detecting injured tissue by detecting the presence of the above described lipid chemoattractant in body fluids such as urine, serum and saliva. The invention also includes a method for reducing recruitment of macrophages to injured tissue by reducing the amount of the above lipid chemoattractant or by blocking the interaction of this lipid chemoattractant with its macrophage binding site. The addition of this lipid chemoattractant to injured skin tissue promotes healing.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 2, 1997
    Assignee: CV Therapeutics
    Inventors: George F. Schreiner, Louis G. Lange, III
  • Patent number: 5436372
    Abstract: The invention is intended to provide novel solid state displacement elements that have an extent of displacement. The solid state displacement element has an intercalation compound in which a polar compound (B) is mixed with an inorganic layered compound (A), and produces a strain when a voltage is applied.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: July 25, 1995
    Assignee: Nippon Soken, Inc.
    Inventors: Hiroyuki Yoshida, Eturo Yasuda, Yoshiaki Fukushima
  • Patent number: 5430181
    Abstract: Process for improving a controlled oxidation reaction between at least one reactant and oxygen, in which at least one reactant is reacted with oxygen or an oxygen containing gas, constituting a reaction mixture, in the presence of at least one additional gas which is introduced into said reaction mixture and is selected from methane, ethane and helium, and the resulting reaction product from the oxidation reaction is possibly treated so as to give a final product.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: July 4, 1995
    Assignee: L'Air Liquide Societe Anonyme Pour L'Etude et L'Exploitation des Procedes Georges Claude
    Inventors: Philippe Arpentinier, Jacques Koenig, Yves Torre
  • Patent number: 5319118
    Abstract: Novel volatile barium complexes are disclosed which are very stable and evaporate cleanly at elevated temperatures. Such complexes are highly suited for use as a barium source in OMCVD processes.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: June 7, 1994
    Assignee: Air Products and Chemicals, Inc.
    Inventors: John A. T. Norman, Beth A. Muratore, Paul N. Dyer
  • Patent number: 5208392
    Abstract: The present invention provides a novel Fe-Pd catalyst prepared by impregnating, either together or respectively, an iron source compound and a palladium source compound onto a carrier selected from the group consisting of silica, alumina and silica-alumina, and drying and calcining said Fe-Pd impregnated carrier in a flow of air or H.sub.2 /N.sub.2 ; and a method for preparing a mixture of cyclohexanol and cyclohexanone by selectively oxidizing cyclohexane in a reaction medium provided with hydrogen and oxygen gases in the presence of said Fe-Pd catalyst.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: May 4, 1993
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Kyu-Wan Lee, Ki-Won Jun, Eun-Kyung Shim
  • Patent number: 5017718
    Abstract: A process for preparing a perfluoroalkyl-substituted compound is disclosed. The process comprises reacting a halopolyfluoroalkane having 1 to 20 carbon atoms with a compound selected from the group consisting of (1) a substituted or unsubstituted ethylene, (2) a substituted or unsubstituted acetylene and (3) a substituted or unsubstituted allylsilane, in the presence of a metal-carbonyl complex of the metal of the Group VIII of the Periodic Table. Alternatively, the reaction between the halopolyfluoroalkane and the substituted or unsubstituted allylsilane is effected under radical generating condition.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: May 21, 1991
    Assignee: Sagami Chemical Research Center
    Inventors: Iwao Ojima, Takamasa Fuchikami