And Other Blood Constituents Patents (Class 600/326)
  • Patent number: 11951256
    Abstract: An oxygen therapy system receives data for an elapsed time such as a flow rate of oxygen gas, and a blood oxygen level or a carbon dioxide partial pressure in arterial blood (PaCO2) level of a user, from an oxygen supply device, calculates a proportion of a duration for each oxygen gas flow rate during which the blood oxygen level or PaCO2 is in a prescribed range from the acquired data in which the oxygen gas flow rate fluctuates with the blood oxygen level or carbon dioxide partial pressure in arterial blood (PaCO2), and displays the calculated data as a histogram or pie graph on a terminal which a healthcare worker such as a physician operates.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: April 9, 2024
    Assignee: Teijin Pharma Limited
    Inventor: Ryo Koizumi
  • Patent number: 11781972
    Abstract: Techniques for selecting a spectroscopic light source include obtaining a light source dataset and a spectroscopic dataset, initializing a genetic algorithm, selecting a first individual solution and a second individual solution from an initial generation of solutions, generating a new individual solution from the first and second individual solutions by combining their respective chromosome encodings, evaluating a specificity of the new individual solution to a target material, adding the new individual solution to a new generation of solutions, populating the new generation of solutions with a plurality of additional individual solutions, generating one or more descendent generations of solutions by iterating the genetic algorithm, selecting one or more implementation individual solutions exhibiting a threshold specificity to the target material, and outputting the one or more implementation individual solutions.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: October 10, 2023
    Assignee: X Development LLC
    Inventors: Gearoid Murphy, Diosdado Rey Banatao, Artem Goncharuk, Neil Treat
  • Patent number: 11730429
    Abstract: Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.
    Type: Grant
    Filed: January 20, 2022
    Date of Patent: August 22, 2023
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Wesley Scott Harper, Annie C. Tan, Timothy Christian Dunn, Mark Kent Sloan, Kenneth J. Doniger, Michael Love, Phillip Yee, Gary Alan Hayter, R. Curtis Jennewine, Glenn Howard Berman, Erich Yen
  • Patent number: 11707232
    Abstract: A technology for a wearable medical device for monitoring medical parameters. Medical measurement data can be received at the wearable medical device from a medical measurement sensor attached to the wearable medical device or a medical measurement sensor in communication with the wearable medical device. A calibration coefficient can be determined for calibrating the wearable medical device based on the medical measurement data. The wearable medical device can be calibrated based on the calibration coefficient.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: July 25, 2023
    Assignee: Tula Health, Inc.
    Inventors: Devin Warner Miller, David Rich Miller, Jeffrey Michael Lee
  • Patent number: 11571131
    Abstract: A method for localizing gingival inflammation using an oral care device, comprising: (i) simultaneously emitting (520) light by a plurality of light sources (48) of the oral care device, wherein at least some of the plurality of light sources emit light of different wavelengths to result in a plurality of emitted light wavelengths, wherein each of the different wavelengths is modulated with a distinct code; (ii) obtaining (530), by a light detector (40) of the oral care device, reflectance measurements from a location within the user's mouth to generate reflectance data for the location; (iii) demodulating (540), by a controller (30) of the oral care device, the obtained reflectance data; and (iv) determining (560), by the controller using the demodulated reflectance data, whether gingiva at the location is inflamed.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 7, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Steven Charles Deane, Alan James Davie
  • Patent number: 11454589
    Abstract: A method and apparatus of non-invasively determining a blood circulatory hemoglobin value for a subject using a near-infrared spectrophotometric (NIRS) sensing device is provided. The method includes: a) non-invasively sensing tissue of the subject using the NIRS sensing device at about a time T1, and determining at least one NIRS tissue totalHb value; b) acquiring at least one circulatory blood sample from the subject at about the time T1; c) determining at least one blood circulatory THb value; d) calibrating the NIRS sensing device using the at least one blood circulatory THb value and the at least one NIRS tissue TotalHb value; and e) determining at least one blood circulatory hemoglobin value using the calibrated NIRS sensing device and the at least one NIRS tissue totalHb value.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: September 27, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Paul B. Benni
  • Patent number: 11452468
    Abstract: A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 27, 2022
    Assignee: Sorin Group Italia S.r.l.
    Inventor: Marco Ranucci
  • Patent number: 11369280
    Abstract: Among the various aspects of the present disclosure is the provision of systems and methods of velocity-matched ultrasonic tagging in photoacoustic flowgraphy.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 28, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Lihong Wang, Xiaoming Wei
  • Patent number: 11285310
    Abstract: A system and method for determining native cardiac output of a heart while maintaining operation of an intracardiac blood pump includes determining a current drawn by the pump motor, a blood pressure within the ascending aorta, and a change in the blood temperature based on a thermodilution technique. An intracardiac blood pump positioned in the aorta includes at least one sensor for determining a motor current and blood pressure and a thermistor for determining the change in blood temperature after a precise fluid bolus has been introduced into the vasculature. A processor receives current, pressure, and temperature measurements, and calculates a pump flow output and a total cardiac output from which the native cardiac output is calculated. The native cardiac output and other clinically relevant variables derived from the measurements inform decisions related to continued therapeutic care, including increasing or decreasing cardiac assistance provided by the intracardiac pump.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: March 29, 2022
    Assignees: Abiomed, Inc., Icahn School of Medicine at Mount Sinai
    Inventors: Jerald Wayne Curran, Kiyotake Ishikawa, Roger J. Hajjar
  • Patent number: 11259723
    Abstract: A sensor (1) for detection of gas, in particular for detection of CO2. The sensor (1) has a contact face (2) which is directed towards a measuring site. The sensor (1) includes at least one radiation source (3), a measurement volume (4) for receiving the gas to be measured, and at least a first detector (5) for detection of radiation transmitted from the source (3) to the first detector (5) through the measurement volume (4). The sensor has a path (6) of the radiation between radiation source (3) and first detector (5). The radiation propagates along the path in a non-imaging way.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: March 1, 2022
    Assignee: SenTec AG
    Inventors: Dominik Rudmann, Peter Matthias Schumacher, Joseph Lang, Simon Caruel, Christoph Ellenberger-Girard, Ross Stanley, Rolf Eckert, Branislav Timotijevic, Maurizio Tormen
  • Patent number: 11259721
    Abstract: Disclosed are a method and device for detecting the concentration of total hemoglobin in blood. A differential path factor corresponding to a subject is determined according to a physiological parameter of the subject and a predetermined table of a corresponding relation between the physiological parameter and the differential path factor.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: March 1, 2022
    Assignee: BOE Technology Group Co., Ltd.
    Inventors: Xun Zhang, Guangfei Li
  • Patent number: 11109763
    Abstract: A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: September 7, 2021
    Inventors: Ji-xin Cheng, Pu Wang, Yingchun Cao, Jie Hui
  • Patent number: 10987066
    Abstract: A patient monitoring system can have a display screen or portion thereof with graphic user interface for displaying indications of a patient's oxygen state. The indications can include the patient's SpO2, dissolved oxygen index, and/or an increasing or decreasing trend of dissolved oxygen index. The displays of oxygen state indications can be compact, and/or able to provide direct visual information to a user of various aspects of the patient's oxygen state. The display elements can be used to represent any other physiological parameters.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: April 27, 2021
    Assignee: Masimo Corporation
    Inventors: Prashanth Rengaswamy Chandran, Anand Sampath, Keith Ward Indorf, Sebastian T. Frey, Bilal Muhsin
  • Patent number: 10827979
    Abstract: A wearable device includes a housing, at least one optical emitter supported by the housing, wherein the at least one optical emitter is configured to generate modulated light, at least one optical detector supported by the housing, and a tip removably secured to the housing. The tip includes first and second portions, wherein the first portion directs light along a first path from the at least one optical emitter to a body of a subject wearing the device, and wherein the second portion directs light from the body of the subject to the optical detector along a second path that is different from the first path. The device may also include an analog-to-digital converter, a motion sensor, and a processor. The processor executes a first filter that attenuates sunlight noise and a second filter that attenuates motion artifacts.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 10, 2020
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer, Eric Douglas Romesburg, Joseph Norman Morris
  • Patent number: 10729358
    Abstract: We describe a user exercise-tolerance measuring pulse oximeter system, for determining the exercise tolerance or capacity of a user undergoing exercise, the system comprising: a wireless fingerband comprising an optical sensor to provide an oxygen saturation signal, a chargeable power supply, and a wireless transmitter/receiver; a motion detector to provide a user motion signal; and a signal processor coupled to said wireless fingerband to data from said optical sensor, and coupled to said motion detector; wherein said signal processor is configured to: process a combination of said oxygen saturation signal and said user motion signal to determine exercise tolerance data, wherein said exercise tolerance data is dependent upon said oxygen saturation signal and a level of exertion of said user determined from said user motion signal; and to time or count a period or quantity of user motion or movements, during said exercise, identified by said motion detector, to determine said level of exertion; to measure a d
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: August 4, 2020
    Assignee: Aseptika Ltd
    Inventors: Paul Thomas Ryan, Kevin Andrew Auton
  • Patent number: 10674948
    Abstract: Embodiments of the present disclosure provide a hypersaturation index for measuring a patient's absorption of oxygen in the blood stream after a patient has reached 100% oxygen saturation. This hypersaturation index provides an indication of the partial pressure of oxygen of a patient. In an embodiment of the present invention, a hypersaturation index is calculated based on the absorption ratio of two different wavelengths of energy at a measuring site. In an embodiment of the invention, a maximum hypersaturation index threshold is determined such that an alarm is triggered when the hypersaturation index reaches or exceeds the threshold. In another embodiment, an alarm is triggered when the hypersaturation index reaches or falls below its starting point when it was first calculated.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: June 9, 2020
    Assignee: Mastmo Corporation
    Inventors: Mohamed K. Diab, Prashanth Iyengar, Anand Sampath, Ammar Al-Ali
  • Patent number: 10656009
    Abstract: A system is configured to discriminate amongst different environments based in part on characteristics of ambient light. Ambient light intensity is measured using a light-sensitive element configured to generate an output signal indicative of an intensity of light incident on the light-sensitive element. A controller is configured to obtain a set of ambient light measurements using the light-sensitive element, and determine that the measurements correspond to a particular ambient light profile. The particular ambient light profile can be one of multiple ambient light profiles that each correspond to a different environment and/or context.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: May 19, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Russell Norman Mirov, Mark Murphy
  • Patent number: 10653348
    Abstract: A method including placing a portion of a foot of a newborn in a device, the device including a light emitter and a corresponding receiver coupled on opposite sides of the device, the device further including a processor for processing data from the light emitter and receiver; and determining a presence of congenital heart disease. An apparatus including a body including a chamber of a size to accommodate a portion of a newborn's foot; at least one light emitter and a corresponding detector coupled on opposite sides of the body, the emitter configured to emit light of a prescribed wavelength into the chamber; and a processor coupled to the body and configured to receive a signal from the at least one detector.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: May 19, 2020
    Assignee: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER
    Inventors: Ruey-Kang Chang, Yann Ping Pan
  • Patent number: 10653347
    Abstract: A method for estimating a local metabolic parameter of an area of tissue of a patient. The method receives light intensities from the area of tissue in question for at least three different wavelengths selected according to the absorptive power of different types of haemoglobin, on the basis of the absorbancy values calculated using the light intensities measured for the three wavelengths. The method determines a oxyhaemoglobin concentration and a deoxyhaemoglobin concentration and estimates at least one local metabolic parameter on the basis of the calculated oxyhaemoglobin and deoxyhaemo-globin concentrations.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: May 19, 2020
    Assignee: APD ADVANCED PERFUSION DIAGNOSTICS
    Inventors: Jan Beute, Remi Bonidal
  • Patent number: 9775546
    Abstract: Embodiments of the present disclosure provide a hypersaturation index for measuring a patient's absorption of oxygen in the blood stream after a patient has reached 100% oxygen saturation. This hypersaturation index provides an indication of the partial pressure of oxygen of a patient. In an embodiment of the present invention, a hypersaturation index is calculated based on the absorption ratio of two different wavelengths of energy at a measuring site. In an embodiment of the invention, a maximum hypersaturation index threshold is determined such that an alarm is triggered when the hypersaturation index reaches or exceeds the threshold. In another embodiment, an alarm is triggered when the hypersaturation index reaches or falls below its starting point when it was first calculated.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 3, 2017
    Assignee: MASIMO CORPORATION
    Inventors: Mohamed K. Diab, Prashanth Iyengar, Anand Sampath, Ammar Al-Ali
  • Patent number: 9763606
    Abstract: A method including placing a portion of a foot of a newborn in a device, the device including a light emitter and a corresponding receiver coupled on opposite sides of the device, the device further including a processor for processing data from the light emitter and receiver; and determining a presence of congenital heart disease. An apparatus including a body including a chamber of a size to accommodate a portion of a newborn's foot; at least one light emitter and a corresponding detector coupled on opposite sides of the body, the emitter configured to emit light of a prescribed wavelength into the chamber; and a processor coupled to the body and configured to receive a signal from the at least one detector.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: September 19, 2017
    Assignee: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER
    Inventors: Ruey-Kang Chang, Yann Ping Pan
  • Patent number: 9662047
    Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: May 30, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Jonathan Feld, David Feld, Alison Hearn, Chae-Ryon Kong, Jeon Woong Kang
  • Patent number: 9636058
    Abstract: An optical sensor unit (10) for measuring a concentration of a gas is provided, comprising at least one sensing layer (122) adapted to be irradiated with a predetermined radiation; at least one gas-permeable layer (121) adjacent to one side of the at least one sensing layer (122) and adapted to pass gas which concentration is to be measured through the gas-permeable layer (121) towards the sensing layer (122); a removable protective layer (150) covering at least the gas-permeable layer (121) and adapted to be removed before use of the optical sensor unit (10), wherein the optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (122), which optical response depends on the concentration of the gas.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: May 2, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Hans Willem Van Kesteren, Josephus Arnoldus Henricus Maria Kahlman, Nicolaas Lambert
  • Patent number: 9408538
    Abstract: The present invention pertains to a method and apparatus for pressure sore detection. A modulated optical signal based on a digital code sequence is transmitted to human tissue. A temporal transfer characteristic is derived from the modulated optical signal. Tissue characteristics is determined based on the temporal transfer characteristic.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: August 9, 2016
    Assignees: Triple Ring Technologies, Inc., Ocela Technologies, Inc.
    Inventors: Lester John Lloyd, Kate Leeann Bechtel, Joseph Anthony Heanue, Brian Patrick Wilfley
  • Patent number: 9404961
    Abstract: A physiological sensor includes a light source and an age detector circuit in communication with the light source. The age detector circuit is configured to determine an age of the light source based on current-voltage characteristics of said light source. In addition, a method includes measuring an initial I-V characteristic and an actual I-V characteristic of the light source, and comparing the initial I-V characteristic to the actual I-V characteristic since changes in the I-V characteristics indicate aging. Actual I-V characteristics can be compared between light sources when they age at different rates to determine light source aging. Moreover, the method may include updating the memory device with the actual I-V characteristic at predetermined times.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: August 2, 2016
    Assignee: Covidien LP
    Inventors: Oleg Gonopolskiy, Arik Anderson, Bruce J. Barrett, Ronald A. Widman
  • Patent number: 9354165
    Abstract: A method and analyzer for identifying, verifying or otherwise characterizing a sample involves emitting electromagnetic radiation in at least one beam at a sample. The electromagnetic radiation includes at least two different wavelengths. A sample detector detects affected electromagnetic radiation resulting from the emitted electromagnetic radiation affected by the sample and provides output representing the detected affected radiation. A processor determines sample coefficients from the output and identifies, verifies or otherwise characterizes the sample using the sample coefficients and training coefficients determined from training samples. The coefficients reduce sensitivity to a sample retainer variation and/or are independent of concentration.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: May 31, 2016
    Assignee: Klein Medical Limited
    Inventors: Raymond Andrew Simpkin, Donal Paul Krouse, Bryan James Smith
  • Patent number: 9320642
    Abstract: The invention provides a method of selecting one or more patient temperature regulation tools is provided. The method comprises: providing a database storing one or more properties of each of a plurality of temperature regulation tools; selecting one or more patient temperature regulation tools from the database; calculating an estimated patient heat balance taking into account one or more of the one or more properties of the selected patient temperature regulation tool(s); providing an indication of the estimated patient heat balance; and providing a visual aid illustrating the one or more selected patient temperature regulation tools regulating the temperature of a patient. The method may be used for selecting one or more patient temperature tools for a patient who is to undergo a medical procedure. Additionally or alternatively, the method may be use as an e-learning tool.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 26, 2016
    Assignee: THE SURGICAL COMPANY INTERNATIONAL B.V.
    Inventors: Robertus Gerardus Van Oudenallen, Berend Jan Teunissen
  • Publication number: 20150073241
    Abstract: The present disclosure provides systems and methods for calibrating medical devices and processing physiological measurements using a medical device management system. As an example, the medical device can be a handheld glucometer configured for invasive testing and non-invasive testing of physiological parameters of a patient.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 12, 2015
    Inventor: Marcelo M. Lamego
  • Publication number: 20150011852
    Abstract: An optical sensor unit (10) for measuring a concentration of a gas is provided, comprising at least one sensing layer (122) adapted to be irradiated with a predetermined radiation; at least one gas-permeable layer (121) adjacent to one side of the at least one sensing layer (122) and adapted to pass gas which concentration is to be measured through the gas-permeable layer (121) towards the sensing layer (122); a removable protective layer (150) covering at least the gas-permeable layer (121) and adapted to be removed before use of the optical sensor unit (10), wherein the optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (122), which optical response depends on the concentration of the gas.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 8, 2015
    Inventors: Hans Willem Van Kesteren, Josephus Henricus Henricus Maria Kahlman, Nicolaas Lambert
  • Publication number: 20140336478
    Abstract: Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations, vital signs and physiological information such as a malignant condition are provided. In some embodiments, the optical sensor includes an array of photodetectors, where each photodetector is configured to detect a spectrum of light. In some embodiments, the image processing device receives a live still or video electronic image, or alternatively, the electronic image is provided from an electronic storage media. Exemplary physiological parameters include but are not limited to a pulse rate, a biophysical or physiological property of skin, a cardiovascular property, a property related to an organ such as the liver or the kidneys, and a temperature fluctuation.
    Type: Application
    Filed: July 28, 2014
    Publication date: November 13, 2014
    Inventor: Yosef SEGMAN
  • Patent number: 8798704
    Abstract: According to various embodiments, a medical system and method for determining a microcirculation parameter of a patient may include a photoacoustic sensor. Specifically, a signal from a photoacoustic sensor may be used to determine if a patient is likely to have sepsis or shock. Although sepsis and shock present similarly with regard to many patient parameters, they may be differentiated by characteristic microcirculation changes.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: August 5, 2014
    Assignee: Covidien LP
    Inventor: Edward M. McKenna
  • Publication number: 20140163329
    Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The system includes a gaze attractor for attracting the gaze of the subject to cause an eye of the subject to move into alignment with regard to an interrogation signal source and/or response signal sensor to facilitate detection of a signal from the eye of the subject.
    Type: Application
    Filed: December 11, 2012
    Publication date: June 12, 2014
    Applicant: Elwha LLC
    Inventors: Allen L. Brown, JR., Douglas C. Burger, Eric Horvitz, Roderick A. Hyde, Edward K.Y. Jung, Eric C. Leuthardt, Jordin T. Kare, Chris Demetrios Karkanias, John L. Manferdelli, Craig J. Mundie, Nathan P. Myhrvold, Barney Pell, Clarence T. Tegreene, Willard H. Wattenburg, Charles Whitmer, Lowell L. Wood, JR., Richard N. Zare
  • Publication number: 20140114144
    Abstract: A system and method for determining a pH level of blood in a vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator. The sensor measures the pH level of blood downstream of the blood clot. A system and method are also provided for determining a density of a blood clot in a vessel of a patient for subsequent selection of a treatment method. The system includes a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator, wherein the sensor determines the density of the blood clot and the indicator provides an indication of the density of the clot.
    Type: Application
    Filed: October 12, 2013
    Publication date: April 24, 2014
    Inventor: Marc-Alan Levine
  • Patent number: 8625087
    Abstract: Disclosed herein is a packing container including: a packing container body including a leading-out section which contains an optical probe having a first end section for incoming of a laser beam and a second end section for outgoing of the incoming laser beam, which leads out the first end section of the optical probe thus contained to the exterior and which is sealed, and a window section by which the laser beam going out from the second end section of the contained optical probe is led out to the exterior; and a light-transmitting member which closes the window section and permits the laser beam to pass therethrough.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: January 7, 2014
    Assignee: Sony Corporation
    Inventor: Yoshiro Takiguchi
  • Publication number: 20130281806
    Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 24, 2013
    Inventors: Govind Rao, Yordan Kostov, Xudong Ge, Leah Tolosa, Hyung Woo, Rose Viscardi
  • Patent number: 8548549
    Abstract: A method for noninvasively measuring analyte levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: October 1, 2013
    Assignee: GLT Acquisition Corp.
    Inventors: Matthew J. Schurman, Walter J. Shakespeare, William Henry Bennett
  • Patent number: 8532737
    Abstract: Apparatus for automatically monitoring sleep, including a video recorder for recording live images of a subject sleeping, including a transmitter for transmitting the recorded images in real-time to a mobile device, and a computing device communicating with said transmitter, including a receiver for receiving the transmitted images in real-time, a processor for analyzing in real-time the received images and for automatically inferring in real-time information about the state of the subject, and a monitor for displaying in real-time the information inferred by said processor about the state of the subject. A method and a computer-readable storage medium are also described and claimed.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: September 10, 2013
    Inventor: Miguel Angel Cervantes
  • Patent number: 8527023
    Abstract: The device for the transcutaneous determination of blood gases including a transcutaneous sensor for the measurement of at least one of the parameters of skin carbon dioxide partial pressure (PsCO2) and skin oxygen partial pressure (PsO2) includes at least one sensor for the measurement of the tissue blood flow (F) local with respect to the transcutaneous sensor, and includes a device for the calculation of at least one of the parameters of transcutaneous carbon dioxide partial pressure (tcpCO2) and transcutaneous oxygen partial pressure (tcpO2) from the measured skin carbon dioxide partial pressure (PsCO2) or the measured skin oxygen partial pressure (PsO2), with a factor dependent on the local tissue blood flow (F) being taken into account in the calculation of at least one of the parameters of transcutaneous carbon dioxide partial pressure (tcpCO2) and transcutaneous oxygen partial pressure (tcpO2).
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: September 3, 2013
    Assignee: Sentec AG
    Inventors: Josef Hayoz, Rolf Wagner
  • Patent number: 8515514
    Abstract: Provided is a method of calibrating a pulse oximeter, in which the effects caused by tissue of a subject can be taken into account. A detector output signal is measured when living tissue of the subject is present between emitters and the detector in a sensor. Nominal calibration and nominal calibration characteristics are read from a memory, whereupon values for the same nominal characteristics for the sensor on living tissue of the subject are established using the detector output signal. Then, changes in the nominal calibration characteristics induced by the living tissue are calculated and a subject-specific calibration is formed by correcting the nominal calibration with the changes. Finally, the hemoglobin fractions are solved using the corrected nominal calibration.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: August 20, 2013
    Assignee: Datex-Ohmeda, Inc.
    Inventor: Matti Huiku
  • Patent number: 8480581
    Abstract: Methods and systems for implantably determining a patient's anemia status and treating anemia are described. Blood viscosity is compared one or more thresholds to determine a patient's anemia status. Therapy, in the form of electrical stimulation therapy or administration of a pharmaceutical delivered to the patient's kidneys or hypothalamus is controlled based on the anemia status.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: July 9, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yunlong Zhang, Bin Mi, John D. Hatlestad
  • Publication number: 20130096403
    Abstract: The present invention generally relates to a non-invasive biosensor device configured to measure physiological parameters of a subject. In one aspect, a method of determining a training threshold of a subject is provided. The method includes the step of detecting an oxygenation parameter of a tissue of the subject using Near InfraRed Spectroscopy (NIRS). The method further includes the step of processing the oxygenation parameter. Additionally, the method includes the step of determining the training threshold of the subject using the result of the processing. In another aspect, a biosensor device for determining a lactate threshold of a subject during exercise is provided. In a further aspect, a biosensor device for measuring parameters of a subject during exercise is provided.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 18, 2013
    Applicant: UNIVERSITY OF HOUSTON SYSTEM
    Inventor: UNIVERSITY OF HOUSTON SYSTEM
  • Patent number: 8401604
    Abstract: Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: March 19, 2013
    Assignee: Glucovista, LLC
    Inventor: Jonathan Gerlitz
  • Patent number: 8320981
    Abstract: An implantable system includes light sources to transmit toward vascularized tissue, in a time multiplexed manner, light having a first wavelength of approximately 660 nm, light having a second wavelength of approximately 810 nm, light having a third wavelength of approximately 910 nm, and light having a fourth wavelength of approximately 980 nm. The system includes one or more light detector to detect light of the first, second, third and fourth wavelengths scattered by vascularized tissue. Additionally, one or more processor is configured to determine levels of blood oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of tissue oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of hemoglobin concentration based on the detected scattered light of the second wavelength, and determine levels of tissue hydration based on the detected scattered light of the second and fourth wavelengths.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: November 27, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Carl Mayer, Craig Seyl, Joseph Lee Hollmann, Eric Weiss, Lyle Frank Weaver, Timothy A. Fayram
  • Publication number: 20120238834
    Abstract: Assessment of a respiratory condition of a subject, by acquiring a temporally varying hemodynamic waveform signal related to blood flow in a tissue; deriving from the hemodynamic waveform signal an evaluation of blood CO2; acquiring at least one more signal; and determining the medical condition based on the blood CO2 and the at least one more signal. A device for performing the assessment may include an implement disposable on the subject's skin and structured to acquire a temporally varying hemodynamic waveform signal and derive from the signal a blood CO2 value or a close approximation thereof; an oximeter disposable on the subject's skin and structured to provide an oxygen saturation value of the blood of the subject or a close approximation thereof; and an apparatus structured to evaluate the medical condition of the subject based on the blood CO2 and oxygen saturation or close approximations thereof.
    Type: Application
    Filed: December 1, 2010
    Publication date: September 20, 2012
    Applicant: NEETOUR MEDICAL LTD.
    Inventor: Ofer Hornick
  • Patent number: 8233960
    Abstract: The present invention provides a method and device of quantitatively or qualitatively examining and diagnosing chronic fatigue syndrome (CFS) by: irradiating a sample derived from an examinee or other animal with light having a wavelength in a range of 400 nm to 2500 nm or a wavelength in part of the range; detecting reflected light, transmitted light, or transmitted and reflected light to obtain an absorption spectral data; and analyzing absorbance at all measurement wavelengths or at specific wavelengths in the absorption spectral data by using an analytical model prepared beforehand.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: July 31, 2012
    Assignees: Fatigue Science Laboratory Inc., Osaka University
    Inventors: Hirohiko Kuratsune, Akikazu Sakudo, Kazuyoshi Ikuta
  • Patent number: 8206650
    Abstract: Some embodiments of the invention provide a system comprising a meter and a disposable cartridge for analyzing a fluid sample typically blood that is drawn into the cartridge by capillary action, negative pressure, positive pressure, or a combination thereof. The cartridge has at least one flow path, and includes at least one optical chamber for spectroscopic measurement, and at least one biosensor for biosensor measurement. The meter has a sample slot for receiving the disposable cartridge. The cartridges have electrical output contacts, and the meter slot has electrical input contacts. When the output contacts mate with the input contacts, the optical chamber becomes positioned for spectroscopic measurement. The present invention can provide joint-diagnostic spectroscopic and biosensor measurements.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: June 26, 2012
    Assignee: Chromedx Inc.
    Inventor: James Samsoondar
  • Patent number: 8190223
    Abstract: Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor advantageously includes a plurality of display modes enabling more parameter data to be displayed than the available physical display real estate.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: May 29, 2012
    Assignee: Masimo Laboratories, Inc.
    Inventors: Ammar Al-Ali, Joe Kiani, Mohamed Diab, Greg Olsen, Roger Wu, Rick Fishel
  • Publication number: 20120123223
    Abstract: A medical system according to embodiments of the present invention includes at least one sensor configured to monitor physiological status of a patient and to generate sensor data based on the physiological status, a user interface device, a processor communicably coupled to the user interface device, the processor configured to: present via the user interface device an array of two or more possible input elements, the input elements each comprising a class of patients or a diagnosis and treatment pathway; receive a selected input element based on a user selection among the two or more possible input elements; acquire the sensor data and process the sensor data to generate physiological data; and present via the user interface screen the physiological data according to a template that is customized for the selected input element.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Inventors: Gary A. FREEMAN, Guy Robert JOHNSON
  • Patent number: 8175668
    Abstract: An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 8, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Yelena Nabutovsky, Gene A. Bornzin, Taraneh Ghaffari Farazi, John W. Poore
  • Patent number: 8143605
    Abstract: A method and system are presented for use in determining one or more parameters of a subject. A region of interest of the subject is irradiated with acoustic tagging radiation, which comprises at least one acoustic tagging beam. At least a portion of the region of interest is irradiated with at least one electromagnetic beam of a predetermined frequency range. Electromagnetic radiation response of the at least portion of the region of interest is detected and measured data indicative thereof is generated. The detected response comprises electromagnetic radiation tagged by the acoustic radiation. This enables processing of the measured data indicative of the detected electromagnetic radiation response to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and outputting data indicative of the at least one determined parameter.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: March 27, 2012
    Assignee: Or-Nim Medical Ltd.
    Inventors: Yaacov Metzger, Michal Rokni, Revital Pery-Shechter