Blood Glucose Patents (Class 600/347)
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Patent number: 8865249Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.Type: GrantFiled: September 28, 2012Date of Patent: October 21, 2014Assignee: DexCom, Inc.Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
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Patent number: 8864664Abstract: A medical device for carrying out at least one medical function. The medical device comprises at least one control part, which can be applied to a body surface of a user, and at least one functional element, which can be inserted into a body tissue of the user at at least one insertion site. The functional element can be connected to the control part. The functional element is designed to carry out at least one medical function. The control part has at least one base part with at least one supporting surface, which faces the body surface. The base part has at least one collection channel for collecting bodily fluid emerging from the insertion site.Type: GrantFiled: August 1, 2011Date of Patent: October 21, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Stephan-Michael Frey, Marc Arnold, Tobias Brugger, Jürgen Braun
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Publication number: 20140309509Abstract: A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.Type: ApplicationFiled: June 24, 2014Publication date: October 16, 2014Inventors: Timothy T. Goodnow, Lei (Lawrence) He
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Publication number: 20140309510Abstract: A wire extends through a ceramic body. The wire comprises a material selected from the group consisting of platinum, palladium, rhodium, iridium, osmium and alloys of platinum, palladium, rhodium, iridium, and osmium. The wire directly contacts the ceramic body to form a substantially hermetic seal between the ceramic body and the wire.Type: ApplicationFiled: June 25, 2014Publication date: October 16, 2014Inventors: Joseph Y. Lucisano, Richard E. Calou, Mark B. Catlin, Joe T. Lin, Timothy L. Routh
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Patent number: 8862197Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.Type: GrantFiled: February 15, 2013Date of Patent: October 14, 2014Assignee: Dexcom, Inc.Inventors: Apurv Ullas Kamath, Peter C. Simpson, Mark Brister
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Patent number: 8862198Abstract: Method and apparatus for providing an integrated analyte sensor and data processing unit assembly is provided.Type: GrantFiled: December 17, 2012Date of Patent: October 14, 2014Assignee: Abbott Diabetes Care Inc.Inventor: Gary Ashley Stafford
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Patent number: 8858435Abstract: An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biologicType: GrantFiled: July 23, 2010Date of Patent: October 14, 2014Assignee: Diabetes Tools Sweden ABInventors: Lars Gustaf Liljeryd, Ulf Frederik Magnusson
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Patent number: 8858434Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 10, 2005Date of Patent: October 14, 2014Assignee: DexCom, Inc.Inventors: Apurv Ullas Kamath, James Brauker, J. Michael Dobbles
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Patent number: 8858768Abstract: The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer.Type: GrantFiled: February 4, 2010Date of Patent: October 14, 2014Assignee: ARKRAY, Inc.Inventors: Koji Katsuki, Yoshiaki Fujinawa, Masashi Tsukada, Yosuke Murase
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Publication number: 20140303465Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.Type: ApplicationFiled: May 19, 2014Publication date: October 9, 2014Applicant: DexCom, Inc.Inventors: Peter C. Simpson, James H. Brauker
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Patent number: 8845530Abstract: A device, system, and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin and receiving, analyzing, and displaying signals from the device such as a sensor are disclosed. A system in accordance with embodiments of the present invention includes a reusable sensor assembly including a transmitter, microcontroller, and housing plus a disposable sensor assembly including a housing having an opening for receiving both the distal end of a biosensor, a sensor insertion guidance structure, and a transmission apparatus for transmitting signals received from the sensor to a reusable sensor assembly for transmission to an external electronic monitoring unit.Type: GrantFiled: December 28, 2007Date of Patent: September 30, 2014Assignee: iSense CorporationInventors: Robert Bruce, Richard G. Sass, W. Kenneth Ward
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Publication number: 20140288402Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: ApplicationFiled: June 2, 2014Publication date: September 25, 2014Applicant: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, James H. Brauker
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Patent number: 8843187Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.Type: GrantFiled: June 1, 2010Date of Patent: September 23, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James Patrick Thrower, Victoria Carr-Brendel
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Patent number: 8840552Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.Type: GrantFiled: December 8, 2009Date of Patent: September 23, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Mark Shults, Mark A. Tapsak
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Publication number: 20140275900Abstract: A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.Type: ApplicationFiled: May 29, 2014Publication date: September 18, 2014Applicant: DexCom, Inc.Inventors: Mark Shults, James H. Brauker, Victoria Carr-Brendel, Mark Tapsak, Dubravka Markovic
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Publication number: 20140275898Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Abbott Diabetes Care Inc.Inventors: Marc Barry Taub, Erwin Satrya Budiman, Xuandong Hua, Michael Love
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Publication number: 20140275896Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: DexCom, Inc.Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring, Huashi Zhang, Mark Wu, David Sze
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Publication number: 20140275899Abstract: Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: April 8, 2014Publication date: September 18, 2014Applicant: MEDTRONIC MINIMED, INC.Inventors: Rebecca K. Gottlieb, Rajiv Shah, Eric A. Larson, Chia Chiu
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Publication number: 20140275897Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Sano Intelligence, Inc.Inventors: Ashwin Pushpala, Alan Szmodis, Matthew Chapman, Weldon Hall, Scott Miller, Hooman Hafezi
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Patent number: 8834384Abstract: Apparatus is provided of locating the fossa ovalis in a patient by locating at least one of the His bundle, the plane of the interatrial septum, and the coronary sinus ostium in a patient, and thereafter locating the fossa ovalis on the basis of one or more predetermined distances between these locations. Software is also provided that can determine and display the location of the fossa ovalis in a patient based on predetermined distances between the locations. Such software can for example be provided within an electroanatomical system. Methods of determining the location of the fossa ovalis, performed by either a clinician or a central processing unit-controlled surgical system, are also provided and determined using predetermined measurements from defined locations. An apparatus for locating the fossa ovalis and performing a transseptal puncture is also provided.Type: GrantFiled: October 12, 2010Date of Patent: September 16, 2014Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.Inventor: Subramaniam C. Krishnan
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Patent number: 8834691Abstract: The objective of the invention is to enhance measurement accuracy in a device for measuring a biological sample. To attain this objective, the invention is provided with a main case (2) having a sensor insertion section (1), a measurement section (7) connected to the sensor insertion section (1), a controller (8) connected to the measurement section (7), and a display (3) connected to the controller (8). An acceleration sensor (5) is furnished for detecting a shock applied to the sensor insertion section (1).Type: GrantFiled: March 28, 2012Date of Patent: September 16, 2014Assignee: Panasonic Healthcare Co., Ltd.Inventors: Reiko Kondo, Takashi Miki, Atsushi Watanabe
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Patent number: 8834366Abstract: Methods and apparatus for providing data processing and control for use in verifying the stability of sensor sensitivity of an analyte sensor.Type: GrantFiled: July 31, 2007Date of Patent: September 16, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Gary Hayter, Geoffrey V. McGarraugh, Andrew H. Naegeli, John C. Mazza, Benjamin J. Feldman, Scott Harper
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Publication number: 20140257065Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: DexCom, Inc.Inventors: Mark Brister, Steve Masterson, John Michael Dobbles, Michael Robert Mensinger, Sean T. Saint, Apurv Ullas Kamath, James H. Brauker, James Patrick Thrower
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Patent number: 8828330Abstract: The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.Type: GrantFiled: January 28, 2010Date of Patent: September 9, 2014Assignee: Abbott Diabetes Care Inc.Inventors: John R. Galasso, Matthew Simmons, Gary Ashley Stafford, Cherie Bulala, Christopher Myles, Philip Justus Wunderle, III, Bonita Song, Richard G. Ries, Morvarid G. Shafie
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Patent number: 8825127Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: May 14, 2010Date of Patent: September 2, 2014Assignee: DexCom, Inc.Inventors: Apurv Ullas Kamath, James Brauker, J. Michael Dobbles
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Patent number: 8821811Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.Type: GrantFiled: September 26, 2012Date of Patent: September 2, 2014Assignee: Google Inc.Inventors: Zenghe Liu, James Etzkorn
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MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING
Publication number: 20140243634Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.Type: ApplicationFiled: February 27, 2013Publication date: August 28, 2014Applicant: Medtronic MiniMed, Inc.Inventors: Ting Huang, Ashwin K. Rao, Rajiv Shah, Qingling Yang -
Patent number: 8816862Abstract: Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.Type: GrantFiled: August 19, 2013Date of Patent: August 26, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Wesley Scott Harper, Annie C. Tan, Timothy Christian Dunn, Mark Kent Sloan, Kenneth J. Doniger, Michael Love, Phillip Yee, Gary Alan Hayter, R. Curtis Jennewine, Glenn Howard Berman
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Publication number: 20140235981Abstract: Methods, system and devices for monitoring control parameters in a closed loop control operation including continuously monitoring glucose level and automatic administration of a medication, detecting a condition associated with hypoglycemia, determining whether a probability of the detected condition associated with hypoglycemia exceeding a threshold level, and outputting a notification based upon the determination are provided.Type: ApplicationFiled: April 29, 2014Publication date: August 21, 2014Applicant: ABBOTT DIABETES CARE INC.Inventor: Gary Alan Hayter
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Publication number: 20140235982Abstract: The present invention relates generally to variable stiffness transcutaneous medical devices including a distal portion designed to be more flexible than a proximal portion. The variable stiffness can be provided by a variable pitch in one or more wires of the device, a variable cross-section in one or more wires of the device, and/or a variable hardening and/or softening in one or more wires of the device.Type: ApplicationFiled: April 30, 2014Publication date: August 21, 2014Applicant: DexCorm, Inc.Inventors: Mark C. Brister, James H. Brauker
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Patent number: 8808182Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: April 27, 2012Date of Patent: August 19, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, James H. Brauker, Apurv Ullas Kamath, James Patrick Thrower
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Patent number: 8812071Abstract: Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.Type: GrantFiled: March 6, 2008Date of Patent: August 19, 2014Assignee: Echo Therapeutics, Inc.Inventors: Han Chuang, James P. Hurley, Joseph Kost
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Patent number: 8812073Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.Type: GrantFiled: June 1, 2010Date of Patent: August 19, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James Patrick Thrower, Victoria Carr-Brendel
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Patent number: 8812072Abstract: The present invention relates generally to variable stiffness transcutaneous medical devices including a distal portion designed to be more flexible than a proximal portion. The variable stiffness can be provided by a variable pitch in one or more wires of the device, a variable cross-section in one or more wires of the device, and/or a variable hardening and/or softening in one or more wires of the device.Type: GrantFiled: April 17, 2008Date of Patent: August 19, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, James H. Brauker
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Patent number: 8802006Abstract: In one aspect, there is provided assembling an analyte sensor with an analyte sensor insertion device, packaging the assembled analyte sensor and sensor insertion device in a substantially airtight seal, and irradiating the packaged assembled analyte sensor and sensor insertion device at a predetermined dose using one or more electron beam accelerators.Type: GrantFiled: August 27, 2012Date of Patent: August 12, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Christopher Allen Thomas, Jasmin Y. Zhao
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Patent number: 8801610Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.Type: GrantFiled: July 24, 2009Date of Patent: August 12, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Victoria Carr-Brendel, Paul V. Goode, Apurv U. Kamath, James P. Thrower, Ben Xavier
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Patent number: 8801611Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 22, 2010Date of Patent: August 12, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, Sean Saint, James Patrick Thrower, Thomas F. McGee, Daniel Shawn Codd, David Michael Petersen, Daniel S. Kline
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Patent number: 8801612Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: April 27, 2012Date of Patent: August 12, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, James H. Brauker, Apurv Ullas Kamath, James Patrick Thrower
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Publication number: 20140221801Abstract: An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: Abbott Diabetes Care Inc.Inventors: James L. Say, Michael Francis Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Phillip John Plante
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Patent number: 8795176Abstract: A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.Type: GrantFiled: July 30, 2007Date of Patent: August 5, 2014Assignee: Abbott Diabetes Care Inc.Inventors: John Bernard Buse, Alan Charles Moses
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Publication number: 20140213868Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: Abbott Diabetes Care Inc.Inventors: Adam Heller, Benjamin Jay Feldman, Shridhara Alva Karinka, Yi Wang, John R. Galasso
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Publication number: 20140213867Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.Type: ApplicationFiled: September 20, 2013Publication date: July 31, 2014Applicant: Google Inc.Inventors: Nathan Pletcher, Brian Otis
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Publication number: 20140213869Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.Type: ApplicationFiled: April 18, 2014Publication date: July 31, 2014Applicant: DexCom, Inc.Inventors: Mark Brister, Sean Saint, Vance Swanson, Nelson Quintana
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Patent number: 8792954Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 19, 2010Date of Patent: July 29, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, James Brauker
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Patent number: 8792955Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: June 9, 2011Date of Patent: July 29, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, Peter C. Simpson, James H. Brauker, James Patrick Thrower, Mark Shults, Rathburn K. Rhodes, Paul V. Goode, Jr., Arnold L. Holmquist
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Patent number: 8792953Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 19, 2010Date of Patent: July 29, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, James Brauker, James Patrick Thrower
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Patent number: 8792956Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: GrantFiled: April 2, 2012Date of Patent: July 29, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
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Patent number: 8788006Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: December 11, 2009Date of Patent: July 22, 2014Assignee: DexCom, Inc.Inventors: Apurv Ullas Kamath, Paul V. Goode, Jr., James H. Brauker
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Patent number: 8788008Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: May 31, 2011Date of Patent: July 22, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath, James P. Thrower
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Patent number: 8788007Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 8, 2012Date of Patent: July 22, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Apurv Ullas Kamath, Paul V. Goode, Mark Brister