Blood Glucose Patents (Class 600/347)
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Patent number: 8986208Abstract: Method and apparatus for receiving a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under the skin layer, receiving a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received substantially contemporaneous to receiving the first signal, detecting a dropout in the signal level associated with one of the first or second signals, comparing the first signal and the second signal to determine a variation between the first and second signals, and confirming one of the first or second signals as a valid glucose sensor signal output when the determined variation between the first and the second signals is less than a predetermined threshold level are provided.Type: GrantFiled: September 30, 2008Date of Patent: March 24, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Gary Hayter, John C. Mazza, Kenneth J. Doniger
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Publication number: 20150080691Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.Type: ApplicationFiled: November 17, 2014Publication date: March 19, 2015Inventors: Robert J. Boock, Chris W. Dring
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Patent number: 8983568Abstract: Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: GrantFiled: September 30, 2008Date of Patent: March 17, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Balasubrahmanya S. Bommakanti, Gary Sandhu, Udo Hoss
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Publication number: 20150073242Abstract: Measuring the impedance of a human body region at a high frequency (ZHF) and a low frequency (ZLF). ZHF is used to obtain the value of the volume of fluid in the tissues of the region. ZLF is used to obtain the value of the volume of extracellular fluid in the tissues. The increase in the metabolic component in the volume of extracellular fluid is determined by the increase of the volume of all of the fluid in comparison with the previous measurement, determining the increase in the volume of extracellular fluid in comparison with the previous measurement and subsequently calculating the difference between the increases in the volume of all of the fluid and the volume of extracellular fluid. The glucose concentration G(tk) is determined by adding the amount of increase in the glucose concentration and the value of the glucose concentration determined at the previous measuring stage.Type: ApplicationFiled: August 22, 2014Publication date: March 12, 2015Inventors: Evgeniy L. SOKOLOV, Andrey A. CHECHIK, Vladimir Y. ELOKHOVSKIY
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Publication number: 20150073243Abstract: Methods and system to provide glycemic control and therapy management based on monitored glucose data, and current and/or target Hb1AC levels are provided.Type: ApplicationFiled: November 12, 2014Publication date: March 12, 2015Applicant: Abbott Diabetes Care Inc.Inventors: Marc Barry Taub, Timothy Christian Dunn, Nathan Christopher Crouther
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Patent number: 8974387Abstract: Various embodiments are described and illustrated to calculate an insulin bolus, recommend such bolus, and provide reminder messages for performing an additional glucose test.Type: GrantFiled: June 30, 2010Date of Patent: March 10, 2015Assignee: LifeScan Scotland LimitedInventors: Ian Shadforth, David Price, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Douglas Graham, Alexander Strachan, Alistair Longmuir, Robert Cavaye, Gillian Teft
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Publication number: 20150065833Abstract: Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a high-boiling point solvent, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: ApplicationFiled: November 17, 2014Publication date: March 5, 2015Inventors: Balasubrahmanya S. Bommakanti, Gary Sandhu, Udo Hoss, Geoffrey V. McGarraugh
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Patent number: 8971982Abstract: Cartridge for a testing device and method of testing using the testing device with the cartridge is disclosed. The cartridge includes a plurality of lancet needles and a mechanism allowing the cartridge to be mounted to the testing device. The method provides for puncturing a surface of skin using the testing device by arranging the testing device adjacent or against a user's skin, triggering the testing device so that one of the plurality of lancet needles is caused to penetrate the user's skin, and rotating the cartridge to another position. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.Type: GrantFiled: March 8, 2005Date of Patent: March 3, 2015Assignee: Stat Medical Devices, Inc.Inventor: Steven Schraga
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Patent number: 8968198Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: January 30, 2012Date of Patent: March 3, 2015Assignee: DexCom, Inc.Inventors: James H. Brauker, Apurv Ullas Kamath
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Patent number: 8971980Abstract: An analyte test device is constructed as an integrated, single-use, disposable cartridge which can be releasably installed into a compatible analyte test monitor. In use, the device can be used in conjunction with the monitor to lance the skin of a patient to create a blood sample and, in turn, calculate the concentration of a particular analyte in the expressed blood sample. In one embodiment, the device includes a base and a cover which are affixed together to create a test cartridge which has a substantially flat and low profile design. A lancet carrier is disposed between the base and the cover and includes a anchor fixedly mounted on the base and a lancet support member which is slidably mounted on the base, the anchor and the lancet support member being connected by a spring. A lancet is removably mounted on the lancet support member is disposed directly beneath an analyte test strip which secured to the underside of the cover.Type: GrantFiled: July 31, 2007Date of Patent: March 3, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Chad Harold Mace, Andrea Nicolaisen, Damon H. Dehart
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Patent number: 8972196Abstract: Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.Type: GrantFiled: June 4, 2010Date of Patent: March 3, 2015Assignee: Medtronic Minimed, Inc.Inventors: Thomas A. Peyser, Soya Gamsey, Matthew A. Romey, David R. Markle
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Patent number: 8965477Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.Type: GrantFiled: April 14, 2011Date of Patent: February 24, 2015Assignee: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Benjamin J. Feldman, Zenghe Liu, Hyun Cho, Benjamin M. Rush
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Patent number: 8965478Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.Type: GrantFiled: October 12, 2012Date of Patent: February 24, 2015Assignee: Google Inc.Inventor: Zenghe Liu
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Publication number: 20150045641Abstract: Systems for rapid and accurate analyte measurement are described. For example, periodic glucose measurements can be achieved with high accuracy in a critical care environment by drawing blood into a device more than once per hour, analyzing blood (for example using infrared radiation through plasma). Safety and accuracy can be achieved by improved fluid control and avoidance of clotting. Data can be conveyed (e.g., displayed) to a user. A user can be allowed to annotate the data. For example, a touchscreen or other interface can allow addition of notes on a running graph of data, indicating events or other items of interest that may correspond to data readings or to particular times.Type: ApplicationFiled: March 13, 2014Publication date: February 12, 2015Inventor: Peter Rule
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Patent number: 8954128Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.Type: GrantFiled: October 18, 2013Date of Patent: February 10, 2015Assignee: DexCom, Inc.Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
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Patent number: 8950068Abstract: A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure has a first side defined by a first layer of bio-compatible material, a second side defined by a second layer of bio-compatible material, an electronic component, and a conductive pattern that defines sensor electrodes. A portion of the second layer of bio-compatible material is removed by etching to create at least one opening in the second side in which the sensor electrodes are exposed. The etching further removes a portion of the first layer of bio-compatible material so as to create at least one opening in the first side that is connected to the at least opening in the second side. With this arrangement of openings, analytes can reach the sensor electrodes from either the first side or the second side of the bio-compatible structure.Type: GrantFiled: September 20, 2013Date of Patent: February 10, 2015Assignee: Google Inc.Inventor: James Etzkorn
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Publication number: 20150038815Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.Type: ApplicationFiled: October 17, 2014Publication date: February 5, 2015Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
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Patent number: 8948836Abstract: An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.Type: GrantFiled: December 26, 2003Date of Patent: February 3, 2015Assignee: Medtronic MiniMed, Inc.Inventors: Bahar Reghabi, Rebecca K. Gottlieb, Rajiv Shah, Bradley J. Enegren, William P. Van Antwerp
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Publication number: 20150031973Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.Type: ApplicationFiled: October 10, 2014Publication date: January 29, 2015Inventors: Ning Yang, Rebecca K. Gottlieb, Kieth Nogueira, Xiaolong Li, Bradely Liang, Brian T. Kannard
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Patent number: 8942779Abstract: Apparatus and methods are described, including a method for detecting an onset of a hypoglycemia episode in a subject. One or more critical parameters for hypoglycemia are monitored without contacting the subject. A variation of at least one of the critical parameters is detected, and an alarm is activated when at least one of the critical parameters deviates from an accepted value. Other applications are also described.Type: GrantFiled: August 7, 2014Date of Patent: January 27, 2015Assignee: Early Sense Ltd.Inventors: Avner Halperin, Arkadi Averboukh, Roman Karasik, Guy Meger
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Publication number: 20150025346Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.Type: ApplicationFiled: October 7, 2014Publication date: January 22, 2015Inventors: Peter C. Simpson, Robert J. Boock, Matthew D. Wightlin
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Method and system for providing data management in integrated analyte monitoring and infusion system
Patent number: 8932216Abstract: Methods and systems for providing therapy related data management are provided. The subject systems include one or more device components, and at least one memory storage unit and at least one data storage unit associated with such one or more device components. The device components may include one or more of an analyte monitoring system, a fluid delivery device and a remote terminal. The subject methods include use of the subject systems to optimize treatment of a patient.Type: GrantFiled: August 7, 2006Date of Patent: January 13, 2015Assignee: Abbott Diabetes Care Inc.Inventor: R. Curtis Jennewine -
Patent number: 8934955Abstract: A cartridge for a testing device and method of testing using the testing device with the cartridge is disclosed. The cartridge includes a plurality of lancet needles, a plurality of test strips, and a mechanism allowing the cartridge to be mounted to the testing device. The method provides for puncturing a surface of skin using the testing device by arranging the testing device against a user's skin, triggering the testing device so that one of the plurality of lancet needles is caused to penetrate the user's skin, placing an amount of blood on one of the plurality of test strips, and rotating the cartridge to another position.Type: GrantFiled: January 18, 2005Date of Patent: January 13, 2015Assignee: Stat Medical Devices, Inc.Inventor: Steven Schraga
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Publication number: 20150005603Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.Type: ApplicationFiled: June 28, 2013Publication date: January 1, 2015Inventors: Zenghe Liu, Jeffrey George Linhardt, Huanfen Yao
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Publication number: 20150005605Abstract: An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. The electrode system also can include a spacer membrane that includes a hydrophilic copolymer of acrylic and/or methacrylic monomers.Type: ApplicationFiled: September 15, 2014Publication date: January 1, 2015Inventors: Arnulf Staib, Marcel Thiele, Karl-Heinz Koelker, Ewald Rieger
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Publication number: 20150005602Abstract: The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring-shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.Type: ApplicationFiled: June 28, 2013Publication date: January 1, 2015Inventors: Jeffrey George Linhardt, Zenghe Liu
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Publication number: 20150005604Abstract: An eye-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a concave surface and a convex surface, with the concave surface configured to removably mount the eye-mountable device on a corneal surface overlaying a pupil. A light source can be disposed on the substrate and configured to emit light through the concave surface and towards the corneal surface such that the emitted light is viewable through the pupil. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to modulate the light emitted by the light source to provide modulated light.Type: ApplicationFiled: June 28, 2013Publication date: January 1, 2015Inventors: William James Biederman, Brian Otis
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Patent number: 8923947Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.Type: GrantFiled: July 23, 2013Date of Patent: December 30, 2014Assignee: DexCom, Inc.Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes, Barbara J. Gilligan, Mark A. Tapsak
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Patent number: 8920319Abstract: In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same.Type: GrantFiled: December 28, 2012Date of Patent: December 30, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Adam Heller, Benjamin Jay Feldman, Shridhara Alva Karinka, Yi Wang, John R. Galasso
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Publication number: 20140378798Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.Type: ApplicationFiled: September 10, 2014Publication date: December 25, 2014Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
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Publication number: 20140374277Abstract: The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Inventors: Matthew Simmons, John R. Galasso, Gary Ashley Stafford, Cherie Bulala, Christopher Myles, Philip Justus Wunderle, III, Bonita Song, Richard G. Ries, Morvarid G. Shafie
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Patent number: 8915849Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: February 3, 2009Date of Patent: December 23, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Apurv Ullas Kamath, Paul V. Goode
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Patent number: 8915850Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.Type: GrantFiled: March 28, 2014Date of Patent: December 23, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Adam Heller, Benjamin Jay Feldman, Shridhara Alva Karinka, Yi Wang, John R. Galasso
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Patent number: 8917184Abstract: Various systems and methods of operating an analyte measurement device is provided. The device has a display, user interface, processor, memory and user interface buttons. In one example, one of the methods can be achieved by measuring an analyte with the analyte measurement device; displaying a value representative of the analyte; prompting a user to activate a test reminder; and activating the test reminder to remind a user to conduct a test measurement at a different time. Other methods and systems are also described and illustrated.Type: GrantFiled: March 20, 2009Date of Patent: December 23, 2014Assignee: Lifescan Scotland LimitedInventors: Antony Smith, Alistair Longmuir, Allan Faulkner
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Publication number: 20140371559Abstract: Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.Type: ApplicationFiled: September 24, 2013Publication date: December 18, 2014Applicant: Google Inc.Inventors: James Etzkorn, Stephen O'Driscoll
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Publication number: 20140371553Abstract: The systems, methods, and devices described herein generally involve monitoring and/or quantification of various analyte levels in a biological fluid using one or more implantable sensors. In various aspects, systems, methods, and devices described herein can provide for the in situ calibration and/or cleaning of such sensors when implanted in the patient. The systems and devices disclosed herein can, for example, continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and periodically calibrate and/or clean the sensor without using finger sticks or additional, invasive calibration techniques. By way of non-limiting example, systems and devices disclosed herein can enable continuous monitoring of analyte concentrations (e.g., glucose) in subcutaneous interstitial fluid for several hours to a few days.Type: ApplicationFiled: December 17, 2012Publication date: December 18, 2014Inventor: James WINKELMAN
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Patent number: 8914090Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.Type: GrantFiled: September 27, 2007Date of Patent: December 16, 2014Assignee: The University of ConnecticutInventors: Faquir Jain, Fotios Papadimitrakopoulos, Diane Burgess, Deborah G. Grantham
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Publication number: 20140364710Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.Type: ApplicationFiled: August 27, 2014Publication date: December 11, 2014Inventors: Fei Mao, Adam Heller
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Patent number: 8900431Abstract: Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.Type: GrantFiled: August 25, 2009Date of Patent: December 2, 2014Assignee: Edwards Lifesciences CorporationInventors: Kenneth Curry, James R. Petisce, Henry Oviatt, Mena Valiket
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Publication number: 20140336486Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: ApplicationFiled: July 29, 2014Publication date: November 13, 2014Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
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Patent number: 8886273Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.Type: GrantFiled: November 7, 2008Date of Patent: November 11, 2014Assignee: Dexcom, Inc.Inventors: Ying Li, Apurv Ullas Kamath, Richard C. Yang
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Patent number: 8886275Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.Type: GrantFiled: September 19, 2013Date of Patent: November 11, 2014Assignee: Google Inc.Inventors: James Etzkorn, Babak Amirparviz
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Patent number: 8886272Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: February 22, 2006Date of Patent: November 11, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Steve Masterson, Sean Saint, Peter Simpson, Matthew D. Wightlin, James R. Petisce, Jack Pryor, Vance Swanson, John Nolting
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Patent number: 8886274Abstract: The estimation of the variation of the glucose level in the blood of a person by the variation of the volume of the interstitial fluid compartments in muscular tissue due to a shift of fluid between the extracellular and intracellular compartments caused by variations of the osmotic pressure of the extracellular fluids which is in turn correlated with the glucose level. The variation of the volume of the interstitial fluid compartments is detected by a non-invasive conductometry measurement using electrodes placed in contact with the skin of the person overlying a portion of soft tissue including muscular fibers. To eliminate the adverse effect of the conductivity of the capillary vessels, the conductivity of the tissue is measured independently in two directions, namely parallel and transverse to the muscular fibers.Type: GrantFiled: August 26, 2009Date of Patent: November 11, 2014Assignee: Gerinova AGInventors: Monica Gericke, Boris A. Paramonov, Ivan Ivanovich Turkovskiy
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Patent number: 8882665Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.Type: GrantFiled: October 26, 2011Date of Patent: November 11, 2014Assignee: Medtronic MiniMed, Inc.Inventors: Ning Yang, Rebecca K. Gottlieb, Keith Nogueira, Xiaolong Li, Bradley Liang
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Patent number: 8880139Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.Type: GrantFiled: September 23, 2013Date of Patent: November 4, 2014Assignee: Google Inc.Inventors: James Etzkorn, Zenghe Liu
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Patent number: 8880137Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: GrantFiled: April 18, 2003Date of Patent: November 4, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
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Patent number: 8870763Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.Type: GrantFiled: February 3, 2012Date of Patent: October 28, 2014Assignee: Medtronic MiniMed, Inc.Inventors: Ning Yang, Rebecca K. Gottlieb, Keith Nogueira, Xiaolong Li, Bradley Liang, Brian T. Kannard
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Patent number: 8874182Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.Type: GrantFiled: January 15, 2013Date of Patent: October 28, 2014Assignee: Google Inc.Inventors: James Etzkorn, Babak Amirparviz
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Patent number: 8868151Abstract: The use of electrical impedance spectroscopy to adjust calibration settings in an in vivo monitoring system, such as an in vivo continuous glucose monitoring sensor. The adjustments can compensate for the condition of the sensor membrane in vivo.Type: GrantFiled: August 16, 2010Date of Patent: October 21, 2014Assignee: Bayer HealthCare LLCInventors: Stanley A. Telson, Raeann Gifford, Jiangfeng Fei, Jeffery S. Reynolds