Blood Glucose Patents (Class 600/347)
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Publication number: 20140200426Abstract: Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.Type: ApplicationFiled: March 14, 2014Publication date: July 17, 2014Applicant: Abbott Diabetes Care Inc.Inventors: Marc Barry Taub, Jai Karan, Annie C. Tan, Timothy Christian Dunn, Joel Goldsmith, Christine M. Neuhaus, Stephen A. Rossi, Sujit R. Jangam
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Patent number: 8781550Abstract: A computer-implemented diabetes management system is provided for configuring a structured collection procedure implemented on a collection device having a meter that measures the concentration of glucose in blood. The system includes: a collection application that executes a structured collection procedure for obtaining measurement data from the meter and provides access to the measurement data via a communication protocol defined in accordance with IEEE standard 11073-20601; a configuration application that accesses and manipulates the parameters of the structured collection procedure using a set of action commands, where the set of action commands are defined in compliance with the communication protocol; and a collection interface that receives an action command from the configuration application, executes the received action command and issues a response command in response thereto, where the response command is defined in compliance with the communication protocol.Type: GrantFiled: December 22, 2010Date of Patent: July 15, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Raymond Strickland, Ulrich Porsch, John Price
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Patent number: 8777852Abstract: An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.Type: GrantFiled: August 22, 2007Date of Patent: July 15, 2014Assignee: Medtronic Minimed, Inc.Inventors: Yanan Zhang, Lu Wang, Rajiv Shah
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Publication number: 20140194713Abstract: Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.Type: ApplicationFiled: September 17, 2013Publication date: July 10, 2014Applicant: GOOGLE INC.Inventor: Zenghe Liu
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Patent number: 8774887Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: GrantFiled: March 24, 2007Date of Patent: July 8, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Fredric C. Colman
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Patent number: 8774888Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: January 20, 2010Date of Patent: July 8, 2014Assignee: DexCom, Inc.Inventors: Apurv Ullas Kamath, Paul V. Goode, Jr., James H. Brauker, James Patrick Thrower
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Patent number: 8774886Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.Type: GrantFiled: October 4, 2006Date of Patent: July 8, 2014Assignee: Dexcom, Inc.Inventors: Mark Brister, Sean Saint, Vance Swanson, Nelson Quintana
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Patent number: 8771500Abstract: Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the working electrode; the first layer of the first hydrogel being operative to store oxygen; wherein the amount of stored oxygen is proportional to the number of freeze-thaw cycles that the hydrogel is subjected to; and a second layer of the second hydrogel. Disclosed too is a method that comprises using periodically biased amperometry towards interrogation of implantable glucose sensors to improve both sensor's sensitivity and linearity while at the same time enable internal calibration against sensor drifts that originate from changes in either electrode activity or membrane permeability as a result of fouling, calcification and/or fibrosis.Type: GrantFiled: October 22, 2008Date of Patent: July 8, 2014Assignee: The University of ConnecticutInventors: Fotios Papadimitrakopoulos, Santhisagar Vaddiraju
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Patent number: 8771485Abstract: A test strip is revealed. The test strip includes a detection area, at least one outer sampling area, and a circuit system. The detection area includes a sampling hole, at least one sampling channel corresponding to the sampling hole, and at least one reaction area in the sampling channel. An inner sampling area is disposed around the sampling hole and an inner sampling opening is on an edge of the inner sampling area for communicating with the sampling channel and the sampling hole. The outer sampling area is located on an outer side of the test strip. The outer sampling area includes an outer sampling opening in communication with the sampling channel. The circuit system is electrically connected to the reaction area. The test strip further includes at least one pressing part located around the sampling hole for pressing against a test area and preventing cross-infection.Type: GrantFiled: January 30, 2012Date of Patent: July 8, 2014Assignee: HMD Biomedical Inc.Inventor: Tien-Tsai Hsu
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Patent number: 8774889Abstract: A patient monitoring system with an efficient pattern matching algorithm, a method, and a computer product thereof are disclosed. The system may include a physiological data input device or sensor which receives a plurality of physiological measurements within a time window thereby generating at least one time window data set, a memory which stores a program, and a processor. The program when executed by the processor, causes the processor to compress the at least one time window data set to a reduced-rank basis, and perform a pattern match between a reference pattern and the compressed at least one time window data set using a distance metric.Type: GrantFiled: December 22, 2010Date of Patent: July 8, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: David Duke, Abhishek S. Soni
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Patent number: 8771187Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: May 31, 2011Date of Patent: July 8, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, Jr., James H. Brauker, Apurv U. Kamath
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Patent number: 8764657Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.Type: GrantFiled: March 30, 2012Date of Patent: July 1, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Samuel Mason Curry, Manuel Luis Donnay, Tuan Nguyen, Louis G. Pace, Peter G. Robinson, Philip Yee
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Publication number: 20140180048Abstract: The present invention relates to a system and method for improving glucose sensor accuracy by utilizing multiple calibration methods and selecting the most accurate method depending on a consensus glucose concentration estimate. Embodiments of the present invention comprise the steps of performing at least one in vivo update of surrounding glucose to acquire glucose values; calculating multiple updated calibration estimates using the updated glucose values; calculating an initial consensus glucose estimate from sensor output using each updated calibration estimate; applying a smooth crossover function to the multiple calibration estimates based on the value of the initial consensus glucose estimate; and adding weights to the multiple calibration estimates to acquire a consensus glucose estimate.Type: ApplicationFiled: December 19, 2013Publication date: June 26, 2014Applicant: BECTON, DICKINSON AND COMPANYInventors: Steven Keith, Yongji Fu, Elaine McVey, Yiwen Zhang
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Publication number: 20140180049Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.Type: ApplicationFiled: February 25, 2014Publication date: June 26, 2014Applicant: DexCom, Inc.Inventors: James H. Brauker, Victoria E. Carr-Brendel, Paul V. Goode, Apurv Ullas Kamath, James Patrick Thrower, Ben Xavier
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Patent number: 8761857Abstract: An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.Type: GrantFiled: April 2, 2012Date of Patent: June 24, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Zenghe Liu, David C. Cohen, Adam Heller
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Patent number: 8760297Abstract: A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.Type: GrantFiled: March 28, 2013Date of Patent: June 24, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Timothy T. Goodnow, Lei (Lawrence) He
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Patent number: 8758245Abstract: A diabetes management system or process is provided herein that may be used to analyze and recognize patterns for a large number of blood glucose concentration measurements and other physiological parameters related to the glycemia of a patient. In particular, a method of monitoring glycemia in a patient may include storing a patient's data on a suitable device, such as, for example, a blood glucose meter. The patient's data may include blood glucose concentration measurements. The diabetes management system or process may be installed on, but is not limited to, a personal computer, an insulin pen, an insulin pump, or a glucose meter. The diabetes management system or process may identify a plurality of pattern types from the data including a testing/dosing pattern, a hypoglycemic pattern, a hyperglycemic pattern, a blood glucose variability pattern, and a comparative pattern.Type: GrantFiled: March 20, 2007Date of Patent: June 24, 2014Assignee: Lifescan, Inc.Inventors: Pinaki Ray, Greg Matian, Aparna Srinivasan, David Rodbard, David Price
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Patent number: 8761856Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.Type: GrantFiled: April 27, 2012Date of Patent: June 24, 2014Assignee: DexCom, Inc.Inventors: Paul V. Goode, James H. Brauker, Apurv Ullas Kamath, James Patrick Thrower
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Publication number: 20140163345Abstract: Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.Type: ApplicationFiled: September 23, 2013Publication date: June 12, 2014Applicant: Metronom Health, Inc.Inventors: Elliot Botvinick, Troy M. Bremer
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Publication number: 20140163346Abstract: Embodiments of the invention provide analyte sensors having optimized electrodes and/or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: December 6, 2012Publication date: June 12, 2014Applicant: MEDTRONIC MINIMED, INC.Inventors: Daniel E. Pesantez, Xiaolong Li, Bradley Chi Liang
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Patent number: 8747316Abstract: An in vivo component measurement method allowing how long a high concentration state of a measurement target component continues in an organism to be grasped is provided. In this in vivo component measurement method, a value relating to an amount of a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made is acquired.Type: GrantFiled: January 28, 2011Date of Patent: June 10, 2014Assignee: Sysmex CorporationInventor: Seiki Okada
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Patent number: 8750955Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: November 2, 2009Date of Patent: June 10, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Steve Masterson, J. Michael Dobbles, Michael Robert Mensinger, Sean Saint, Apurv Ullas Kamath, James Brauker, James Patrick Thrower
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Patent number: 8744547Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.Type: GrantFiled: July 9, 2012Date of Patent: June 3, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Erwin Satrya Budiman, Wesley Scott Harper, Timothy Christian Dunn
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Patent number: 8744546Abstract: The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain.Type: GrantFiled: April 28, 2006Date of Patent: June 3, 2014Assignee: DexCom, Inc.Inventors: James R. Petisce, Kum Ming Woo, Victor Ha, Melissa Nicholas
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Patent number: 8744545Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: GrantFiled: March 3, 2009Date of Patent: June 3, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Fredric C. Colman
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Publication number: 20140148668Abstract: Described are methods and systems to allow users to select a basic mode or an advanced mode in which additional features can be customized for the user based on structured queries presented to the user.Type: ApplicationFiled: November 29, 2012Publication date: May 29, 2014Applicant: LifeScan, Inc.Inventors: Sweta CHOVANDA, Shawn Berven
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Publication number: 20140148669Abstract: The present invention relates to a device for continuous measuring of an analyte which allows monitoring the blood or interstitial glucose level in a minimally invasive, minimally detrimental and painless manner for which it basically comprises a fixed element (1) on which there is fixed a disposable and exchangeable element (2) incorporating an automated multi-puncturing system programmable over time comprising a plurality of puncturing units each formed by a micro-needle (3), means for driving said micro-needle (3), an elastic spring (10) returning it to its resting state and a biosensor wherein the glucose data which is subsequently transmitted to an external reading and management device is extracted.Type: ApplicationFiled: September 1, 2011Publication date: May 29, 2014Inventors: Javier Francisco Garcia Saban, Jordi Marsinyach Montfort
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Patent number: 8734346Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: GrantFiled: April 30, 2007Date of Patent: May 27, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
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Patent number: 8738109Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.Type: GrantFiled: March 3, 2009Date of Patent: May 27, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
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Patent number: 8731630Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 22, 2010Date of Patent: May 20, 2014Assignee: DexCom, Inc.Inventors: Apurv Ullas Kamath, James Brauker, J. Michael Dobbles
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Patent number: 8730058Abstract: Described herein are analyte monitoring systems including a receiver or data processing component that is configured to automatically issue a first alert notification when a first predetermined number of consecutive data packets are not received from the sensor/sensor electronics, and automatically issue a second alert notification when a second predetermined number of consecutive data packets are not received by the sensor/sensor electronics. The receiver may also be configured to enable a user to disenable alert or alarm notifications that are triggered based on detected events.Type: GrantFiled: July 29, 2013Date of Patent: May 20, 2014Assignee: Abbott Diabetes Care Inc.Inventor: Wesley Scott Harper
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Publication number: 20140135605Abstract: A method is provided for initializing an analyte sensor, such as a glucose sensor. Where a sensor has been disconnected and reconnected, a disconnection time is determined and a sensor initialization protocol is selected based upon the disconnection time. The sensor initialization protocol may include applying a first series of voltage pulses to the sensor. A method for detecting hydration of a sensor is also provided.Type: ApplicationFiled: November 13, 2012Publication date: May 15, 2014Applicant: Medtronic MiniMed, Inc.Inventors: Rebecca K. Gottlieb, Chia-Hung Chiu, Ashwin K. Rao
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Patent number: 8721545Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: GrantFiled: March 22, 2010Date of Patent: May 13, 2014Assignee: DexCom, Inc.Inventors: Mark Brister, Paul V. Neale, Sean Saint, James Patrick Thrower, Thomas F. McGee, Daniel Shawn Codd, David Michael Petersen, Daniel S. Kline
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Patent number: 8721544Abstract: The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.Type: GrantFiled: March 20, 2008Date of Patent: May 13, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Bernd Roesicke, Karin Obermaier, Stefan Lindegger, Andreas Menke, Joerg Scherer, Karin Schwind, Otto Gaa, Gregor Bainczyk, Michael Marquant, Sandro Niederhäuser, Michael Schoemaker, Martin Mueri
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Publication number: 20140128704Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.Type: ApplicationFiled: December 31, 2013Publication date: May 8, 2014Applicant: DexCom, Inc.Inventors: Peter C. Simpson, Robert J. Boock, James R. Petisce, Mark C. Brister, Monica A. Rixman, Kum Ming Woo, Lisa Nguyen, Seth R. Brunner, Arthur Chee, Melissa A. Nicholas, Matthew D. Wightlin, Jack Pryor, Dubravka Markovic
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Publication number: 20140128701Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.Type: ApplicationFiled: December 30, 2013Publication date: May 8, 2014Applicant: DexCom, Inc.Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes
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Publication number: 20140128703Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.Type: ApplicationFiled: December 31, 2013Publication date: May 8, 2014Applicant: DexCom, Inc.Inventors: Peter C. Simpson, Robert J. Boock, Mark C. Brister, Monica A. Rixman, Kum Ming Woo, Lisa Nguyen, Seth R. Brunner, Arthur Chee, Melissa A. Nicholas, Matthew D. Wightlin, Jack Pryor, Dubravka Markovic
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Publication number: 20140128700Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.Type: ApplicationFiled: December 30, 2013Publication date: May 8, 2014Applicant: DexCom, Inc.Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes
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Publication number: 20140128702Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.Type: ApplicationFiled: December 30, 2013Publication date: May 8, 2014Applicant: DexCom, Inc.Inventors: Mark Brister, James R. Petisce, Peter Simpson
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Patent number: 8718739Abstract: Methods and devices to detect analyte in body fluid are provided. Embodiments include positioning an analyte sensor in fluid contact with an analyte, detecting an attenuation in a signal from an analyte sensor after positioning during a predetermined time period, categorizing the detected attenuation in the analyte sensor signal based, at least in part, on one or more characteristics of the signal, performing signal processing to generate a reportable data associated with the detected analyte sensor signal during the predetermined time period, managing if and when to request additional reference signal measurements, and managing if and when to temporarily not display results.Type: GrantFiled: December 28, 2012Date of Patent: May 6, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Wesley Scott Harper, Timothy Christian Dunn, Erwin Satrya Budiman, Kenneth J. Doniger, Gary Alan Hayter
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Publication number: 20140121485Abstract: A device contains individually controllable sites for electrochemically monitoring an analyte in interstitial fluid of a user. The sites include a conductive pattern attached at a first and second ends thereof to electrode material in a closed-circuit configuration for receiving a first predetermined voltage applied thereto in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid and form an open-circuit configuration including first and second portions of the electrode material that are electrically isolated from each other; a sensing area deposited on at least one of the first and second portions of the electrode material; and a measuring component for receiving individual measurement data from the sensing area in response to a second predetermined voltage applied to the open circuit configuration. The individual measurement data is indicative of an amount of the analyte in the interstitial fluid.Type: ApplicationFiled: April 30, 2012Publication date: May 1, 2014Applicant: Georgetown UniversityInventors: Makarand Paranjape, Arend Jasper Nijdam, Yogesh Ekanath Kashte
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Publication number: 20140121486Abstract: A disposable biosensor test strip includes a plurality of penetrating members, which are associated with a capillary chamber having a depth suitable for capillary flow of blood and holds a volume of less than about 1.0 .?l of the blood sample. A working electrode and a counter or reference electrode are disposed within the capillary chamber. A reagent is proximal to or in contact with at least the working electrode. The reagent includes an enzyme and a mediator. The reagent reacts with glucose to produce an electroactive reaction product. A blood sample, containing glucose, is applied into the capillary chamber. The capillary chamber directs capillary flow of the blood sample into contact with the reagent to cause the blood sample to at least partially solubilize or hydrate the reagent. The blood sample is detected in the capillary chamber. The electroactive reaction product is electro-oxidized or electro-reduced at the working electrode.Type: ApplicationFiled: January 7, 2014Publication date: May 1, 2014Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Dominique M. Freeman, Dirk Boecker
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Patent number: 8710993Abstract: Methods, devices, and kits are provided for mitigating single point failure of at least one device in an analyte monitoring system.Type: GrantFiled: November 21, 2012Date of Patent: April 29, 2014Assignee: Abbott Diabetes Care Inc.Inventors: Gary Alan Hayter, Marc Barry Taub
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Patent number: 8709739Abstract: Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.Type: GrantFiled: September 14, 2012Date of Patent: April 29, 2014Assignee: LifeScan, Inc.Inventors: Ronald C. Chatelier, Alastair McIndoe Hodges, Santhanagopalan Nandagopalan
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Publication number: 20140114158Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: DexCom, Inc.Inventors: Mark C. Brister, Steve Masterson, John Michael Dobbles, Michael Robert Mensinger, Sean Saint, Apurv Ullas Kamath
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Publication number: 20140114156Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: DexCom, Inc.Inventors: Sebastian Bohm, Daiting Rong, Peter C. Simpson
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Publication number: 20140114155Abstract: A self-contained hand-held test device for the single-use determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing with proximal and distal ends, a housing cap configured for removable attachment to the distal end of the housing, a single analytical test strip (e.g., a single electrochemical-based analytical test strip) disposed partially in the housing and extending from the distal end thereof, a meter module disposed in the housing, and a lancing module attached to the proximal end of the housing. The lancing module is configured to lance a user's target site (such as a fingertip or other suitable site) for the expression of a bodily fluid sample. In addition, the single analytical test strip has a bodily fluid sample application portion and a meter module contact portion and is operably connected to the meter module in user irreplaceable manner.Type: ApplicationFiled: October 18, 2012Publication date: April 24, 2014Applicant: Animals CorporationInventor: Michael HUTCHINSON
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Publication number: 20140114159Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: DexCom, Inc.Inventors: Mark Brister, James R. Petisce, Peter Simpson
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Publication number: 20140114157Abstract: A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: DexCom, Inc.Inventors: Jorge Valdes, David Price, Leif N. Bowman, Kristin Cote
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Patent number: 8706180Abstract: An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.Type: GrantFiled: June 10, 2013Date of Patent: April 22, 2014Assignee: Abbott Diabetes Care Inc.Inventors: James L. Say, Michael Francis Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Phillip John Plante