Abstract: A method for determining functional severity of a stenosis includes: (a) generating a simulated perfusion map from a calculated blood flow; (b) comparing the simulated perfusion map to a measured perfusion map to identify a degree of mismatch therebetween, the measured perfusion map representing perfusion in a patient; (c) modifying a parameter in a model used in calculating the blood flow when the degree of mismatch meets or exceeds a predefined threshold; (d) computing a hemodynamic quantity from the simulated perfusion map when the degree of mismatch is less than the predefined threshold, the hemodynamic quantity being indicative of the functional severity of the stenosis; and (e) displaying the hemodynamic quantity. Systems for determining functional severity of a stenosis are described.

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide-aperture collimation-deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract: The present invention provides a radiation blocking unit including: an attachment member that is attachable between sources and an object table surface to which radiation from a radiation source and visible light from a visible light source are emitted, the sources including the radiation source and the visible light source; a radiation blocking portion, disposed on the attachment member, that transmits the illuminated visible light to an overlapping incidence region on the object table surface in which an incidence region of the radiation and an incidence region of the visible light overlap, and that blocks the irradiated radiation outside the overlapping incidence region; and a visible light blocking portion, disposed on the attachment member, that transmits the irradiated radiation to the overlapping incidence region, and blocks the illuminated visible light outside the overlapping incidence region.

Abstract: An integrated magnetic resonance (MR) and positron emission tomography (PET) system includes an MR scanner including a magnet that defines an opening in which a subject is positioned, a set of PET detectors disposed between the magnet and the opening, and a plurality of data processing units, each data processing unit being configured for communication with a respective one or more of the PET detectors of the set of PET detectors. The plurality of data processing units are positioned along a side of the MR scanner not having the opening.

Abstract: A radiographic imaging apparatus comprising: a radiation detector configured to be detachable with respect to a patient platform and detect radiation transmitted through an object in one of a moving image capturing mode and a still image capturing mode; a detection unit configured to detect a shift timing of an image capturing mode; a cooling mechanism configured to cool the radiation detector in one of a first cooling mode and a second cooling mode having a higher cooling capacity than the first cooling mode; and a control unit configured to switch the cooling modes of the cooling mechanism based on detection by the detection unit.

Abstract: Embodiments of the present disclosure include methods of imaging a target area, methods of monitoring the degeneration of cartilage, and the like.

Abstract: A system and method for treating tissue uses an ultrasound therapy system including an ultrasonic applicator having has at least one transducer element. Steering and focusing of ultrasound beams uses at least one variable focus lens, which may be a fluid focus lens, attached to each transducer element so that focus of the variable focus lens is controlled by a voltage signal. A treatment controller receives input from an imager and controls the voltage applied to the variable focus lens. The treatment controller controls the lens voltage signals, at least partially determined by the input from the imager, and directs an ultrasonic treatment beam emitted by the transducer element. Fine adjustment of the therapy beam is achieved to deliver therapy for various prostate sizes and shapes while avoiding damage to critical structures such as the rectal wall and nerve bundles.

Abstract: The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.

Abstract: A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the senior wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

Abstract: A method of treating a cancerous region in a breast of a patient comprising (i) imaging the breast in a three-dimensional coordinate system, (ii) stereotactically determining the location of the cancerous region in the breast, (iii) optionally determining the volume of the entire cancerous region to be treated, and (iv) while maintaining the breast in a three-dimensional coordinate system that is identical to or corresponds with the three-dimensional coordinate system used in (i), noninvasively exposing the cancerous region of the breast of the patient to a cancer-treatment effective dose of radiation; and equipment for use in such a method.

Abstract: Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy.

Abstract: A scanning assembly for a dual-modality automated biological tissue imaging device having first and second compression surfaces is provided. The system comprises a housing defining a scanning/compression surface, an ultrasonic transducer mounted within the housing adjacent the scanning surface for movement in a plane parallel to the scanning surface and imaging the tissue through the scanning surface, an X-ray detector mounted within the housing for forming an X-ray image of the tissue based on X-ray radiation passed through the tissue and scanning surface from an X-ray source, and a drive for moving the transducer across the scanning surface so that the transducer generates a plurality of two-dimensional ultrasound tissue images. The housing is hermetically sealed and filled with non-conductive fluid with acoustic impedance resembling that of the tissue. The scanning surface has acoustic impedance resembling that of the tissue and can substantially withstand compression forces applied to the tissue.

Abstract: According to one embodiment, a nuclear medicine diagnostic apparatus includes a counting unit, a region of interest setting unit, a normalization unit, and an image generation unit. The counting unit counts radiation emitted from radioisotopes in an imaging region of an object. The ROI setting unit sets a region of interest (ROI) in the imaging region. The normalization unit determines association between count values and pixel values of display pixels for the ROI in accordance with a distribution of the count values of the display pixels corresponding to the ROI. The image generation unit generates an image of the ROI based on the association between the count values and the pixel values for the ROI.

Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.

Abstract: The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm.

Abstract: Apparatus and methods for measuring radiation levels in vivo in real time. Apparatus and methods include a scintillating material coupled to a retention member.

Abstract: A dual modality endocavity imaging and treatment system for detection of cancer and targeted biopsy and treatment procedures, comprising: a housing; a nuclear detector system housed within the housing and configured for detecting nuclear radiation imaging data; an ultrasound detector system housed within the housing for detecting ultrasound imaging data; a needle associated with the housing and adjustably positionable relative thereto; and a data processing module configured to receive the nuclear radiation imaging data and the ultrasound imaging data and to generate and output an image showing the relative position of the needle and an endocavity object of interest.

Abstract: The present disclosure relates to a bone fracture risk assessment method and system. The method may include generating a volumetric model corresponding to a three-dimensional image of a bone structure for each bone structure in a set of bone structures. The method may further include defining a vector of variables for each bone structure. Each variable in the vector of variables may include a three-dimensional position of one of a number of volumetric vertices and at least one parameter associated with the one volumetric vertex. The method may include generating a set of individual vectors and performing variable reduction on the set of individual vectors. The method may further include determining a discriminator based at least in part on a result of the variable reduction.

Abstract: A magnetic resonance imaging (MRI) apparatus suitable for radiotherapy. The apparatus includes two sets of coil pairs, each coil pair forming a Maxwell-like coil. The two sets of coil pairs share a common transverse plane, have opposing polarities, and define a common plane of symmetry and an imaging area. The two sets generate a substantially homogenous electromagnetic field in a first transverse direction in the imaging area and peripheral electromagnetic fields in a direction opposite to the first transverse direction in a peripheral area. The apparatus also includes at least one focusing magnet positioned in the peripheral areas to generate a focusing electromagnetic field in a focusing area, in a direction substantially the same as the first transverse direction. At least a portion of the peripheral electromagnetic fields is maintained in a defocusing area between the focusing area and the imaging area.

Abstract: A method and a system are provided for performing volume rendering a 3D array of image data to produce images with an increased spatial information and thus increase the usefulness of the generated images.

Abstract: A method for reconstructing list mode data comprises: reconstructing all list mode data of a list mode data set (30, 160) to generate a first reconstructed image (32, 62); selecting a sub-set of the list mode data set; and reconstructing the sub-set of the list mode data set to generate an enhanced reconstructed image (84, 86). An image generation system comprises: a reconstruction module (24) configured to perform a standard reconstruction of a list mode data set to generate a standard reconstructed image (32, 62); and a re-reconstruction module (24, 70, 80, 82, 150, 152, 154) configured to perform a reconstruction other than the standard reconstruction of at least a portion of the list mode data set to generate an enhanced reconstructed image (84, 86).

Abstract: In a small animal imaging system (10) at least one modality (12) and a docking station (36) are provided. The docking station (36) provides a workspace (47) and docking ports (48) for preparation and holding of anesthetized animals that are awaiting imaging. For the duplication of positions, a subject mold (26) is provided that holds the subject in a reproducible position on a subject bed (16). Vital signs monitoring is also provided for subjects awaiting scans. The bed (16) includes fiducials (28) to aid in registration of like modality images and different modality images. A capsule (14) can encapsulate a single bed (16), or for tandem imaging, the capsule can encapsulate multiple-bed configurations, such as two, three, or four beds (16). For better positioning and ease of user access, a positioner (34) positions the capsule (14) from the rear of the modality (12).

Abstract: A probe for detecting K-alpha photon emissions. A housing has an aperture at an end. A detector crystal is situated within the housing adjacent to the housing aperture. An energy conversion device is situated within the housing between the detector crystal and the aperture. The energy conversion device is made from a predetermined material configured to convert energy directed through the housing aperture from a source of primary photon emission radiation to a corresponding secondary K-alpha emission within a predetermined emission energy acceptance window. A power supply is coupled to the detector crystal and is configured to establish a polarized electrical field between the anode and the cathode of the detector crystal. The detector crystal receives the K-alpha emission and generates an electrical signal representative of the amount of target emissions received through the housing aperture.

Abstract: Using a three-dimensional medical image representing a heart as input, a cardiac function analysis unit calculates a cardiac function evaluation value representing a cardiac function with respect to each of predetermined portions of the heart, using a three-dimensional medical image representing the heart as input, a myocardial infarction analysis unit calculates a myocardial infarction rate representing a degree of myocardial infarction with respect to each of predetermined portions of the heart, and a superimposed image output unit outputs a superimposed image representing the cardiac function evaluation value and the myocardial infarction rate in a superimposing manner such that they are distinguishable from each other in a coordinate system capable of representing each position of the heart in the three-dimensional medical image.

Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

Abstract: Embodiments provided herein relate to ionizing radiation detectors for use with endoscopic ultrasounds. In some embodiments, an apparatus is provided and includes an ultrasound transducer and an ionizing radiation detector, such as a scintillating detector. The ionizing radiation detector can comprise a scintillating material and a photodetector.

Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.

Abstract: An integrated Positron Emission Tomography (PET)/Computed Tomography (CT) system includes a patient support device supporting a patient pallet, a gantry having a space through which the patient pallet passes, a plurality of integrated PET/CT detector modules attached to one side of the gantry, an x-ray tube attached to the other side of the gantry, and a signal detecting/processing unit. Each of the plurality of integrated PET/CT detector modules include a plurality of PET detectors, a flat-panel x-ray detector disposed in contact with the PET detectors and a read-out driver mounted at a rear end of the PET detectors and electrically connected with the flat-panel x-ray detector.

Abstract: In a magnetic resonance device having a PET unit for acquiring positron emission tomography data and a gradient coil, the PET unit includes a carrier tube on which at least one PET detector is arranged. In at least one embodiment, the carrier tube is arranged inside the gradient coil and is displaceably mounted in such a way that access to the PET detector is made possible by its displacement. This allows easy access to the PET detector during maintenance activities.

Abstract: A method of evaluating tissue of an organ includes performing at least one of classification processing and clustering processing to obtain a processed dataset to visualize at least one of the imaging agent, blood, the contrast agent, and the biomedical agent distribution in the tissue, a relative regional uptake of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent in the tissue, relative regional flow of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent and the clearance or persistence of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent within the tissue and the characterization of elemental components of disease.

Abstract: A brain imaging system can be operated to obtain brain image signals indicating activity at brain locations, and information can be extracted from the brain image signals. For example, for each of a set of living human brain regions that can have two or more possible activity features such as qualia features, feature values can be obtained indicating activity features of the region. The feature values can be more explicit than brain image data indicating activity at brain locations. A data structure can be produced that includes data indicating extracted information, such as qualia value data for a quale activity feature that can occur in a region. Such a data structure can be stored on a storage medium and used in diagnosis and/or treatment of detrimental conditions of consciousness.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: A method of imaging, comprising: (a) providing an isotope at a low dosage in a body of a patient; (b) receiving radiation generated by said isotope from said body using a radiation camera; and (c) reconstructing a 3D distribution of said isotope from said received radiation, wherein the dosage is less than ? of a standard dose set forth in Table 5.

Abstract: Provided is radiation detection equipment including: a semiconductor radiation detector which has a semiconductor crystal made of thallium bromide; a capacitor which applies a voltage to the semiconductor radiation detector; and at least one DC power source which accumulates positive charges and negative charges in either of electrodes of the capacitor. Herein, a cathode and an anode in the semiconductor radiation detector are formed of at least one kind of a metal selected from gold, platinum and palladium. Further, the DC power source periodically reverses a voltage of accumulating the positive charges and a voltage of accumulating the negative charges in either of the electrodes of the capacitor per interval shorter than 10 min, thereby to apply the resulting voltage thereto.

Abstract: A system for the measurement of radiation emitted from an in-vivo administered radioactive analyte. The system employs a sensor having a scintillation material to convert gamma radiation to visible light, which enables embodiments of the sensor to be ex vivo. A light detector converts the visible light to an electrical signal. This signal is amplified and is processed to measure the captured radiation. Temperature of the sensor may be recorded along with this radiation measurement for temperature compensation of ex vivo embodiments. The sensor enables collection of sufficient data to support separate application to predictive models, background comparisons, or change analysis.

Abstract: A method and a device for imaging a volume section by way of PET data are described. With the proposed solution the PET data of the volume section are acquired by way of a positron emission detector, and the MR data of the volume section are acquired by way of a magnetic resonance system. In at least one embodiment, with the aid of the MR data, PET voxels within the volume section are determined from which radiation occurring due to an annihilation is emitted. The image data are reconstructed from the PET data in that it is taken into account that the PET data are generated only by radiation from the PET voxels.

Abstract: A method of processing image data that includes obtaining image data, determining a phase of a respiratory cycle, and associating the image data with the determined phase within 60 seconds, and more preferably, within 15 seconds, after the image data is obtained. A system for processing image data that includes a processor configured for obtaining image data, determining a phase of a respiratory cycle, and associating the image data with the determined phase within 60 seconds, and more preferably, within 15 seconds, after the image data is obtained. A method of processing image data that includes obtaining image data during an image acquisition session, determining a phase of a respiratory cycle, and associating the image data after the image data is obtained but before the image acquisition session is completed.

Abstract: Methods and systems for multiple scatter estimation in Positron Emission Tomography (PET) are provided. One method includes determining attenuation sinograms and determining a varying convolution kernel as a function of the attenuation sinograms, wherein the kernel varies in amplitude and width over a radial length of a PET imaging system. The method also includes using the varying convolution kernel to estimate multiple PET scatter.

Abstract: A modified atmosphere package for extending the shelf life of a replaceable transducer cartridge having a sealed volume and containing a fluid. The fluid may be fluid or a gas. If a fluid, such as water, then the modified atmosphere package may be configured to prevent the loss of fluid or the entry of gas into the transducer cartridge.

Abstract: A proton beam collimator comprising (a) titanium or (b) stainless steel containing no tungsten or (c) containing no tungsten or brass. The collimator comprises a multi-leaf collimator (MLC). The apparatus further comprises an integrated circuit (IC) mounted adjacent the collimator, the IC subject to exposure to atomic particles, illustratively, neutrons.

Abstract: A method of identifying injury to soft connective tissues in complicated body joints deploys use of motion x-ray images as the joint moves to identify suspected abnormal pathology followed by Dynamic Upright MRI images of the joint under conditions that express the abnormal pathology. The Dynamic Upright MRI parameters are based on the suspected pathology. The method is particularly useful in detecting disco/ligamentous and other injuries that often times will not be visualized on conventional recumbent MRI, or static x-rays.

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide aperture collimation—deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.

Abstract: When estimating an arterial input function or a patient under study, cross-calibration factors are generated by comparing nuclear scan data of a radioactive material (e.g., F18) and measuring a sample of the radioactive material in a gamma counter. The derived cross-calibration factors are applied to venous samples collected from the patient during a nuclear scan after infusion with a radioactive tracer, to convert gamma values counted by the gamma counter into concentration values. The concentration values are used to optimize an initial estimated input function, thereby generating an arterialized input function.

Abstract: Robotic navigation is provided for nuclear probe imaging. Using a three-dimensional scanner (19), the surface of a patient is determined (42). A calibrated robotic system positions (48) a nuclear probe about the patient based on the surface. The positioning (48) may be without contacting the patient and the surface may be used in reconstruction to account for spacing of the probe from the patient. By using the robotic system for positioning (48), the speed, resolution and/or quality of the reconstructed image may be predetermined, user settable, and/or improved compared to manual scanning.

Abstract: A method and apparatus for compensating for motion in an imaged object are provided. The method includes obtaining nuclear medicine (NM) image data for an object acquired from an NM imaging system, wherein the NM image data includes single photon emission computed tomography (SPECT) image data. The method further includes performing resolution recovery on the NM image data. The method also includes reconstructing the resolution recovered NM image data into a plurality of subsets and morphing the reconstructed NM image data in at least one of the plurality of subsets. The method additionally includes normalizing the NM image data based on a magnitude of the morphing and summing the NM image data to generate an NM image compensated for motion of the object.

Abstract: A radiation detector (16) having a first detector layer (24) and a second detector layer (26) encircles an examination region (14). Detectors of the first layer include scintillators (72) and light detectors (74), such as avalanche photodiodes. The detectors of the second detector layer (26) include scintillators (62) and optical detectors (64). The scintillators (72) of the first layer have a smaller cross-section than the scintillators (62) of the second layers. A group, e.g., nine, of the first layer scintillators (72) overlay each second group scintillator (62). In a CT mode, detectors of the first layer detect transmission radiation to generate a CT image with a relatively high resolution and the detectors of the second layer detect PET or SPECT radiation to generate nuclear data for reconstruction into a lower resolution emission image. Because the detectors of the first and second layers are aligned, the transmission and emission images are inherently aligned.

Abstract: One or more techniques and/or systems described herein provide for generating a radiographic image and ultrasound image depicting parallel planes of an object under examination and may be used in conjunction with radiographic or ultrasound techniques known to those in the field (e.g., x-ray tomosynthesis, computed tomography ultrasound imaging, etc.). An ultrasound frontend component is configured to transmit ultrasound waves in a direction substantially parallel to a trajectory of radiation. In one example, one or more radiographic images of an object are spatially coincident to one or more ultrasound images of the object in the same position and/or geometric shape/volume, and the images may be combined to generate a combined image depicting features of the ultrasound image (e.g., the sensitivity of the ultrasound image) and features of the radiographic image (e.g., the morphological details of the radiographic image).

Abstract: Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Abstract: An imaging system for use in a medical intervention procedure is disclosed. A first image acquisition system is configured to produce a fluoroscopy image of an anatomical region. A second image acquisition system is configured to produce a 3D model of the anatomical region. An interventional tracking system, which includes a position indicator, is configured to maneuver within the anatomical region. A first anatomical reference system is common to both the first and the second image acquisition systems, and a second anatomical reference system is common to both the first image acquisition system and the interventional tracking system.