Abstract: Apparatus and methods for attenuating environmental interference are described. A wearable monitoring apparatus includes a housing configured to be attached to the body of a subject and a sensor module that includes an energy emitter that directs energy at a target region of the subject, a detector that detects an energy response signal—or physiological condition—from the subject, a filter that removes time-varying environmental interference from the energy response signal, and at least one processor that controls operations of the energy emitter, detector, and filter.

Abstract: Gastric emptying classification systems, displays, methods for classifying gastric emptying data, methods for treating patients, and methods for developing gastric emptying classification systems are disclosed.

Abstract: Gastric emptying classification systems, displays, methods for classifying gastric emptying data, methods for treating patients, and methods for developing gastric emptying classification systems are disclosed.

Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.

Abstract: With a pulse-height analyzer, a reference-pulse generator generates a reference pulse of a given pulse height for a given period of time when an analog radiation pulse inputted to a comparator is higher than an initial threshold. A capacitor and a resistor receive the reference pulse, and then increase an increment threshold for the given period of time from the initial threshold to the given pulse height. Then the increment threshold is set as a reference voltage of the comparator. A pulse time width of the analog radiation pulse is determined through measuring a period of time from timing where the analog radiation pulse exceeds the initial threshold to timing where the analog radiation pulse being attenuated falls below the increment threshold.

Abstract: In a medical visualization method, wherein: a series of organ slice images are acquired at different points in time by an imaging modality; the acquired organ slice images are stored in an image data memory with information about the series and/or the point in time of the acquisition. A data connection between an input/output device and the image data memory is established and the available series are determined. Series that are specific to the organ are symbolically represented with a display of the availability thereof. The organ slice images associated with a selected series are displayed. An input/output device as well as a computer program product operates according to the method.

Abstract: Methods, systems, and computer-readable mediums are provided that determine the angular orientation of detectors and detector electronic assemblies (“DEAs”). In various embodiments, the orientation of detectors/DEAs (in the ring) is determined with respect to other detectors/DEAs in the ring, the orientation of the detectors/DEAs with respect to a patient bed, or the orientation of the detectors/DEAs with respect to Earth's gravitational field. In another embodiment, a nuclear medical imaging system has one or more detector units arranged around or that can be swept around a patient bed. Each of the detector units includes an angular orientation-sensing accelerometer. By determining angular orientation of the detector from signals outputted by the accelerometer, the circumferential position of the detector relative to the patient bed can be determined. That information is used in conjunction with information about detected events to construct an image of an organ or tissue mass of interest.

Abstract: A method for developing a prediction device for predicting a phenotype of a person from imaging data of the person is provided. The method includes determining imaging descriptors, the determining imaging descriptors including acquiring multidimensional images of people with an imaging apparatus and extracting multidimensional image elements from the acquired multidimensional images to serve as descriptors The method also includes classifying the predetermined descriptors on the basis of the capability thereof to predict the phenotype, selecting, from among the classified descriptors, a relevant number of the best-classified descriptors that is sufficient to predict the phenotype and constructing the prediction device from the selected descriptors.

Abstract: A system (100) including a catheter mounted magneto sensor (114), such as a superconducting quantum interference device (SQUID), and methods using the system are disclosed, where the system and method are designed to detect changes in a magnetic field in a body of interest, such as a patient, to detect changes in a magnetic field in a patient, to identify loci in a target body that accumulate magnetic particles or to identify vulnerable plague in a patient.

Abstract: A method for quantifying the uptake of at least one radiotracer in a body region of a patient of interest to a positron emission tomography measurement is disclosed. In at least one embodiment of the method, the uptake of the radiotracer in the body region of the patient of interest to the positron emission tomography measurement is quantified taking into account at least one permeability information item relating to the permeability of at least one blood vessel of the patient, in particular in the body region of interest.

Abstract: What is described here is a process and a device for deep-selective detection of spontaneous activities and general muscle activities in biological tissue. In this process, photons of a coherent and monochromatic electromagnetic radiation of the wavelength ?1 penetrate the tissue in the range between 600 and 1,200 nm and re-emerge from the tissue at differently distanced areas, then being detected with regard to frequency and number or intensity. By means of an evaluation program or algorithm, this information in connection with the respective area as point of emergence of the photons allows conclusions to be drawn about the muscle activity and/or number of active muscles and/or the physical position of the active muscles in the tissue.

Abstract: The invention relates generally to biopsy needle guidance which employs an x-ray/gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.

Abstract: A dynamic diagnosis support information generation system includes: a radiation generator capable of irradiating a pulsed radiation; a radiation detector which is provided with a plurality of detecting elements arranged in two-dimension, detects the pulsed radiation irradiated from the radiation generator at each of the plurality of detecting elements and generates frame images successively; and an analysis section which calculates and outputs a feature value relating to a dynamic image of a subject based on a plurality of frame images generated by radiographing the subject by using the radiation generator and the radiation detector, wherein the analysis section calculates the feature value relating to the dynamic image of the subject by corresponding pixels to each others representing outputs of a detecting element at a same position in the radiation detector among the plurality of the frame images.

Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.

Abstract: A system and method for detecting an area of interest such as a pulmonary embolism in a structure of interest such as a vessel tree or airway tree are provided. The method comprises: segmenting image data of the structure of interest; and rendering two-dimensional images based on a function of the image data and the segmented image data within slabs defined by the segmented image data.

Abstract: A first embodiment can be a device comprising a means to define cancer margin definition of a tumor resection specimen via radiotracer uptake using a table top, mobile 3D PET imager in the operating room.

Abstract: Provided herein are robotic or automated multimodal tissue scanning or imaging systems and methods. The systems comprise a robotic delivery device configured to mechanically scan one or more zones of a tissue by co-registering at least two modalities, i.e., one or more of each of a sensor modality and an imaging modality and acquiring sensor modality data at one or more positions in the zone(s) as the sensor modality is dimensionally translated along the device axes. The system also comprises a computational core of a plurality of interlinked modules for planning, processing, tissue-sampling, visualization, fusion, and control of the delivery device and the system. The methods provided herein utilize the automated systems to produce spatial maps based on the analyzed sensor modality data.

Abstract: A computer implemented method for providing cardiovascular images over a respiratory cycle through a computer system is provided. A plurality of cardiovascular images is obtained. A cardiac phase is measured for each cardiovascular image of the plurality of cardiovascular images to associate each cardiovascular image to a cardiac phase. A respiratory phase is measured for each cardiovascular image of the plurality of cardiovascular images to associate each cardiovascular image to a respiratory phase. A first group of cardiovascular images with an associated first cardiac phase of the plurality of cardiovascular images is sorted in order of respiratory phases. The first group of cardiovascular images with the associated first cardiac phase of the plurality of cardiovascular images is displayed in order of respiratory phases.

Abstract: The present system and method for simulating particles and waves is useful for calculations involving nuclear and full spectrum radiation transport, quantum particle transport, plasma transport and charged particle transport. The invention provides a mechanism for creating accurate invariants for embedding in general three-dimensional problems and describes means by which a series of simple single collision interaction finite elements can be extended to formulate a complex multi-collision finite element.

Abstract: A detector unit for arrangement in a field generating unit of a magnetic resonance device has an RF transmission/reception system for transmitting RF pulses into, or receiving magnetic resonance signals from, an examination volume of the field generation unit. The RF transmission/reception system surrounds a patient tunnel at a radial distance from a tunnel axis thereof, and is divided into two sub-systems located at a distance from each other along the direction of the tunnel axis, so as to form a substantially annular cavity or interstice therebetween.

Abstract: A sandwich structure which attenuates the PET radiation minimally, is used as a support tube for the transmit antenna. In at least one embodiment, it includes a thin strong inner wall, a likewise thin and strong outer wall and an interior of the support tube which is of the honeycomb type or is made of foam material.

Abstract: Improved compounds have been developed which are structured to be sequestered with very high specificity in acidic areas of tissues. When the compounds contain a radioisotope effective to report the presence of the compound the compounds are for detecting tumors containing hypoxic/acidic areas. When the compounds contain radioisotopes effective to kill cells the compounds are for treating tumors containing hypoxic/acidic areas. Methods for detecting and treating tumors with such compounds are also disclosed.

Abstract: Systems and methods are described for co-registering, displaying and quantifying images from numerous different medical modalities, such as CT, MRI and SPECT. In this novel approach co-registration and image fusion is based on multiple user-defined Regions-of-Interest (ROI), which may be subsets of entire image volumes, from multiple modalities, where the each ROI may depict data from different image modalities. The user-selected ROI of a first image modality may be superposed over or blended with the corresponding ROI of a second image modality, and the entire second image may be displayed with either the superposed or blended ROI.

Abstract: A method and apparatus for marking a lesion in a body part is provided. The method includes the steps of obtaining a first nuclear-emission image of the body part; determining a position of the lesion from the first image; percutaneously introducing a cannula to the determined position; inserting a wire into the cannula, the wire including radioactive material; retracting the cannula while holding the wire in place; and obtaining a second nuclear-emission image of the body part. The second image includes data relating to a position of the lesion and data relating to a position of the wire.

Abstract: An RF antenna arrangement of a combined MR/PET system is disclosed. In at least one embodiment, the RF antenna arrangement includes a first part installed in the examination tunnel in a fashion fixed to the system such that it is arranged underneath the couch board when the latter is introduced, and a second part, which can be placed onto the couch board and be introduced into and withdrawn from the examination tunnel together with the couch board. In at least one embodiment, the second part is of dimensionally stable design and has a clear cross section that is adapted to the object to be examined. Consequently, the time outlay for applying the RF antenna is reduced, and the fixed position of the RF antenna enables a correction of the attenuation of gamma rays. Furthermore, a number of second parts having various diameters can be provided.

Abstract: An apparatus and method for localizing a nuclear-emitting lesion during an intervention using correlated nuclear and ultrasound imaging. The apparatus provides interventional access and quasi-stereotactic positioning of interventional devices, with real-time ultrasound image visualization for tracking the approach of the device to the lesion. The apparatus is intended to overcome the shortcomings of fully-stereotactic nuclear-emission image localization.

Abstract: Intraoperative radiation detection probes and cameras for use in surgical or transcutaneous procedures or procedures incorporating probes inserted through body orifices to aid in the location, detection and removal of radiation labeled cells, abnormal tissue or deposits thereon incorporate solid state or silicon photomultiplier (SSPM, or SiPM) devices to provide safe, highly sensitive and compact beta and gamma probes or cameras for use in locating the radiation labeled sites within the human body or abnormal labeled sites within the body. The probes may include both gamma and beta detecting components as well as means for enhancing the accuracy and sensitivity of the beta detectors.

Abstract: The invention relates to methods and systems for compensating for respiratory motion of individuals during nuclear imaging. In some embodiments, the methods include obtaining data representing a reference respiratory state for the individual and obtaining data that represents a plurality of respiratory states that correspond to at least a portion of a cycle of respiration of the individual; comparing each of the plurality of respiratory states to a subset of the reference state data to obtain a motion estimate of each of the plurality of respiratory states; compensating for respiratory motion in each of the plurality of respiratory states based on the motion estimates to obtain motion-compensated respiratory state data; and constructing an image using the motion-compensated respiratory state data.

Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. Specifically, the ingestible device may be arranged to perform a diagnostic image of nuclear radiation of a radiophamaceutical, scintillation of a scintillation liquid, responsive to nuclear radiation of a radiophamaceutical, optical fluorescence of a fluorescing-pharmaceutical or of bare gastrointestinal-tract tissue, infrared radiation of the gastrointestinal-tract tissue, temperature-differences along the gastrointestinal-tract, impedance, ultrasound reflection, magnetic resonance, and a combination thereof. The ingestible device may be adapted for general screening of a large population, on the one hand, and for specific diagnoses of suspected pathologies, on the other.

Abstract: A method of generating a computed tomography image is disclosed herein. The method includes acquiring a first plurality of projections at a first energy level and acquiring a second plurality of projections at a second energy level. The method includes reconstructing an image from the first plurality of projections and generating a synthesized projection from the image that corresponds to one of the second plurality of projections. The method includes comparing the synthesized projection to the one of the second plurality of projections and modifying the image to form an updated image based on the comparing the synthesized projection to the one of the second plurality of projections. A computed tomography imaging system is also disclosed.

Abstract: A three-dimensional detector module for use in detecting annihilation photons generated by positrons emitted from radio-labeled sites within a body is formed from multiple solid state photo-detectors attached to one or more scintillators. Each photo-detector can be attached to a scintillator to form a photo-detector/scintillator combination and multiple photo-detector/scintillator combinations can be arranged in an array. Alternatively, multiple photo-detectors can be attached to the surface of a single scintillator to form an array. Multiple arrays are then stacked to form a photo-detector module. The modules can then be assembled to form a sheet of photo-detector modules. Multiple sheets or multiple modules can then be arranged around a body to detect emissions from radio-labeled sites in the body.

Abstract: A radiolabeled annexin comprising at least 2 up to 20 histidine residues at its N-terminus is disclosed. At least two of said histidine residues are adjacent or separated by no more than one other amino acid. The radiolabeled annexin is a stable complex with a radionuclide such as technetium 99m. The radiolabeled annexin can be used in a method of imaging cell death in a nucleated cell within a region of a mammalian subject in vivo.

Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. An imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract: A method for imaging a body, including scanning the body so as to generate a tomographic image thereof, and analyzing the tomographic image to determine a location of a region of interest (ROI) (38) within the body. The method includes providing single photon counting detector modules (40), each of the modules being configured to receive photons from a respective direction and to generate a signal in response thereto. The method further includes coupling each of the modules to a respective adjustable mount (54), adjusting each of the adjustable mounts so that the direction of the module coupled thereto is aligned with respect to the location so as to receive radiation from the ROI, operating each of the modules to receive the photons from the ROI, and, in response to the signal generated by each of the modules, generating a single photon counting image of the ROI.

Abstract: Provided is a data acquisition system comprising a CPU, radiation detector, buffer, and a storage device in communication with the buffer and which is capable of storing information received from the buffer. The data acquisition system includes a method for sequentially monitoring data from one region of interest based on data obtained from a previous region of interest, and finally recording the data of a final region of interest for use as medical data.

Abstract: Disclosed is a thyroid uptake measurement apparatus, in which a radiation attenuation filter is detachably provided at the leading end of a collimator of a radiation detector. The radiation attenuation filter inhibits the saturation of signals when gamma rays exceeding the maximum counting rate are entered. Accordingly, it is possible to inhibit the distortion of signals when the pile-up of the signals increases by an increase in the radiation decay. Moreover, the use of the radiation attenuation filter can significantly improve the scatter fraction, that is, the ratio of scattered radiation/total radiation generated by material scatter of radiation.

Abstract: A region of interest is automatically evaluated. The automatic evaluation is based on assessments of one or more characteristics. The one or more characteristics of the region of interest are assessed in a plurality of image data sets acquired by a respective plurality of imaging modalities. In some embodiments, the evaluation is based on assessments of one or more characteristics for each region of interest derived from a combination of structural and functional image data. In one embodiment, the set of structural image data is a set of CT image data and the set of functional image data is a set of PET image data. The one or more lesions may be detected in the structural and/or functional image data by automated routines or by a visual inspection by a clinician or other reviewer.

Abstract: The design of a compact, handheld, solid-state and high-sensitivity imaging probe and a micro imager system is reported. These instruments can be used as a dedicated tool for detecting and locating sentinel lymph nodes and also for detecting and imaging radioactive material. The reported device will use solid state pixel detectors and custom low-noise frontend/readout integrated circuits. The detector will be designed to have excellent image quality and high spatial resolution. The imaging probes have two different embodiments, which are comprised of a pixelated detector array and a highly integrated readout system, which uses a custom multi-channel mixed signal integrated circuit. The instrument usually includes a collimator in front of the detector array so that the incident photons can be imaged. The data is transferred to an intelligent display system. A hyperspectral image can also be produced and displayed. These devices are designed to be portable for easy use.

Abstract: A radiation imaging system which captures a radiographic image obtains examination information including the patient information of a patient as a target for the imaging and imaging information defining the contents of imaging executed for the patient, controls the radiation imaging of a patient in accordance with the examination information, stores the captured radiographic image in association with the patient information of the image, and switches and displays, within one window, an imaging screen used for imaging based on the examination information and a playback screen used for playback of the stored radiographic image. The apparatus then detects a switching instruction for display of a displayed screen based on input operation by an operator, compares patient information corresponding to the imaging screen with patient information corresponding to the playback screen when display switching is performed based on the switching instruction, and notifies the operator of the comparison result.

Abstract: A method of imaging, including receiving radioactive radiation from a body; reconstructing a 3D SPECT image of a distribution of radiation in at least one voxel of said body; and reconstructing a dynamic change in radiation in said voxel, as an updated image, at a rate of faster than one change per 5 minutes, wherein said reconstructed image is a clinically useful image including a resolution of 10 mm or better for a voxel volume of at least 5 cm in diameter and a contrast to background ratio of radiation of at least 2:1.

Abstract: The invention relates to detection of radiations by means of any appropriate devices, particularly those comprising small probes used e.g. in diagnostics or in surgery, or in biomedical or pharmacological research. The aim of the invention is to improve the performance of probes and their working methods in terms i.a of background, miniaturization sensitivity and selectivity.

Abstract: A system, method, and computer program product of clinical treatment planning implements complex Monte Carlo (MC) based brachytherapy dose distributions using conventional brachytherapy treatment planning systems (TPS). Dose distributions from complex brachytherapy source configurations determined with MC methods are used as inputs. Radial dose functions and 2D anisotropy functions are obtained by positioning the coordinate system origin along the dose distribution cylindrical axis of symmetry. Origin to tissue distance and active length are chosen to minimize TPS interpolation errors. A 2D anisotropy function is determined, and a brachytherapy dose rate constant is selected. A virtual brachytherapy source dose distribution is calculated based upon the complex treatment configuration. Additional dosimetry parameters may be considered as well, and dose distributions may be calculated and compared to the original MC-derived dose distributions.

Abstract: A reference height calibration procedure obtains a reference error value, which can be used to adjust a height calibration parameter for registering the fields of view (FOVs) of the modules of a multi-modality medical imaging system such as a SPECT-CT imaging system.

Abstract: A nuclear medicine imaging simulator system is provided for simulating nuclear imaging of a target within a phantom using a selected pharmacokinetic model. The system includes a processor assembly having at least one processor receiving a digital phantom model and a digital pharmacokinetic model, and a dynamic integration module executable on the processor assembly for integrating the pharmacokinetic model with the phantom model to generate a dynamic phantom data representing activity of the pharmacokinetic model within the phantom model over simulated time.

Abstract: An implantable medical apparatus comprises a solid state electronic circuit, an ionizing radiation exposure sensor, an ionizing radiation dose rate sensor, and a controller circuit. The ionizing radiation exposure sensor is configured to detect an exposure of the solid state electronic circuit to ionizing radiation, and generate an indication of a non-single-event-upset (non-SEU) effect to the solid state electronic circuit from the exposure to ionizing radiation, wherein the sensor comprises an accumulated ionizing radiation exposure sensor. The controller circuit is configured to blank the indication from the accumulated ionizing radiation exposure sensor when the radiation dose rate sensor indicates that flux ionizing radiation exceeds a flux ionizing radiation threshold.

Abstract: An ingestible pill platform for colon imaging is provided, designed to recognize its entry to the colon and expand in the colon, for improved imaging of the colon walls. On approaching the external anal sphincter muscle, the ingestible pill may contract or deform, for elimination. Colon recognition may be based on a structural image, based on the differences in diameters between the small intestine and the colon, and particularly, based on the semilunar fold structure, which is unique to the colon. Additionally or alternatively, colon recognition may be based on a functional image, based on the generally inflammatory state of the vermiform appendix. Additionally or alternatively, pH, flora, enzymes and (or) chemical analyses may be used to recognize the colon. The imaging of the colon walls may be functional, by nuclear-radiation imaging of radionuclide-labeled antibodies, or by optical-fluorescence-spectroscopy imaging of fluorescence-labeled antibodies.

Abstract: Systems and methods for generating persistence images in nuclear medicine (NM) imaging are provided. One method includes acquiring a nuclear emission image of a patient injected with a radiopharmaceutical in a persistence data acquisition mode. The method further includes determining an assigned display color corresponding to NM persistence image information including detected nuclear activity from the radiopharmaceutical for each of a plurality of event count values. The method also includes color mapping the acquired NM persistence image information using the assigned display colors and generating with a processor a color NM persistence image based on the color mapping. The method additionally includes displaying the generated color NM persistence image.

Abstract: A method and a system to acquire and manage timed counts are provided. The timed counts are captured by a gamma probe. For example, a system to acquire the timed counts may comprise a timed counts receiver to receive timed counts during a session of a medical procedure in which the timed counts are captured. A database stores the timed counts in memory during the session of the medical procedure. The database is accessible to generate a user interface during the session or a report based on the stored timed counts.

Abstract: A method for acquiring MR data from a beating heart during subject respiration includes a prescan phase in which a respiratory compensation table and a k-space sampling schedule are produced. The k-space sampling table is produced using a spatio-temporal model of the beating heart and time sequential sampling theory. During the subsequent scan an imaging pulse sequence which is prospectively compensated for respiratory motion is used to acquire k-space data from the subject. The imaging pulse sequence is repeated to play out the phase encodings in the order listed in the k-space sampling schedule.

Abstract: A hybrid radioactive and impedance tracking system for tracking a target in a human or animal body, comprising: a) a radioactive tracking subsystem for tracking the target; b) an impedance tracking subsystem for tracking the target; and c) a processor that uses data from the radioactive tracking subsystem in combination with data from the impedance tracking system to estimate a position of the target.