Abstract: The present invention relates to methods and devices that may be used to extract spatial frequency information. In one embodiment, the invention provides an instrument configured to extract data using a two-dimensional (2D) Hilbert transform technique, and providing spatial frequency information from a sample. In another embodiment, the invention provides a spatial frequency domain imaging (SFDI) device adapted for demodulation using two or less imaging frames.

Abstract: An imaging system can include an optical fiber and a light source for providing optical stimulation to a region of interest along the optical fiber. A camera can capture emission such as fluorescence resulting from the optical stimulation. A cannula configured for implantation into a subject can be configured to direct the emission from the subject. A mating sleeve coupling the cannula to the optical fiber, and configured to support the camera, can include a dichroic mirror to allow the optical stimulation to pass from the optical fiber to the cannula and to redirect the emission from the cannula to the camera.

Abstract: The disclosed embodiments relate to a system that displays an image of the characteristics of the biological tissue. During operation, the system enables a user to illuminate a measurement location in an area of interest on the biological tissue by manipulating a point measurement probe, wherein the point measurement probe delivers both an excitation beam and an overlapping aiming beam that is visible to a camera. Next, the system obtains fluorescence information from a fluorescence signal emitted from the measurement location in response to the excitation beam. The system then captures an image of the area of interest using the camera and identifies a portion of the image that corresponds to the measurement location by identifying a location illuminated by the aiming beam. Finally, the system generates an overlay image by overlaying the fluorescence information onto the portion of the image that corresponds to the measurement location, and then displays the overlay image to a user.

Abstract: This invention relates to an apparatus and a method for measuring whether organic matter is present or whether or not organisms (cells or tissue) are alive using infrared absorption spectroscopic analysis. The measurement apparatus of the invention includes an infrared light source for radiating infrared rays on a sample, an infrared detection unit for detecting the infrared rays transmitted or reflected from the sample, and a determination unit for identifying an amide infrared absorption peak of the sample using the detected infrared rays and for determining whether organic matter is present or whether organisms are alive or not in the sample using the identified amide infrared absorption peak. In this invention, a reagent is not used, simple measurement is performed, quantification is feasible, and the presence or absence of cells or tissues and changes in the life and death can be consecutively measured for the same sample.

Abstract: Systems and methods for discriminating between malignant and benign pigmented skin lesions based on optical analysis using spatial distribution maps, morphological parameters, and additional diagnostic parameters derived from images of tissue lesions. A handheld optical transfer diagnosis device is disclosed capable of capturing a series of reflectance images of a skin lesion at a variety of angles of illumination and observation.

Abstract: A bio-information detecting apparatus includes: a band member curved in a C-shape, and attached around a neck part of an examinee from a back side of the neck part; and a pair of electrodes for cardiac potential measurement disposed at positions on the band member that come into contact with right and left skin surfaces of the neck part, and in the pair of electrodes, a position of the electrode on the right is located relatively more frontward than a position of the electrode on the left. The bio-information detecting apparatus further includes a substrate to optically measure a blood oxygen saturation for pulse measurement at a position on the band member that comes into contact with the neck part of the examinee, and a pressing force of the substrate against the skin surface of the neck part is 0.96 to 1.21 [N/cm2].

Abstract: A furniture system includes a chair having a seat, a backrest coupled to the seat, and a base supporting the backrest and the seat. The furniture system also includes a plurality of sensors and a processor. Each sensor is operable to detect a physical force imparted by a user on the chair, and generate an output signal indicative of the physical force. The processor is coupled to the plurality of sensors, and is operable to receive the output signals generated by the plurality of sensors, and determine, based on at least one of the output signals, a current posture of the user sitting in the chair.

Abstract: A Raman microscopy imaging device (100) is described, having: a first laser light source (12) for emitting a first laser beam (16) having a first wavelength along a first light path (20); a second laser light source (44) for emitting a second laser beam (18) having a second wavelength, different from the first wavelength, along a second light path (22) physically separated from the first light path (20); a beam combining element (32) for collinearly combining the two laser beams (16, 18) in one shared light path (34) directed onto a sample; a detector (38) for sensing a measured signal on the basis of the two laser beams (16, 18) interacting with the sample; and an evaluation unit (40) for evaluating the measured signal sensed by the detector (38). According to the present invention the first laser light source (12) is embodied as a pulsed source, and the second laser light source (44) as a continuous source.

Abstract: An imaging device may include a first illumination port to output first light having a first illumination distribution at a target to illuminate the target, a second illumination port to output second light having a second illumination distribution at the target to illuminate the target, the second illumination distribution being substantially similar to the first illumination distribution at the target, the second illumination port being spaced apart from the first illumination port, the first and second illumination distributions being simultaneously provided to the target and overlapping at the target. The illumination from the first and second ports may be matched to a same aspect ratio and field of view coverage as the imaging field of view.

Abstract: An apparatus for turbid sample measurement comprising a plurality of light sources for illuminating a turbid sample target area with non-spatial structured light, a projection system for illuminating the turbid sample target area with spatial structured light, a sensor for collecting light from the turbid sample target area, and a processor to analyze the data captured by the sensor to yield scattering and absorption coefficients of the turbid sample. A method comprises illuminating the sample with spatial structured light, collecting light reflected from the sample at a number of wavelengths, illuminating the sample with non-spatial structured light, collecting light reflected from the sample at a number of wavelengths, and combining the measurements of the collected light to obtain the optical properties of the sample and/or the concentration of absorbing or fluorescent molecules. The wavelengths of the spatial and non-spatial light sources are preferably different.

Abstract: Laser assisted cataract surgery methods and devices utilize one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may be applied to the anterior lens capsule to facilitate laser thermal separation of tissue along a treatment beam path on the lens capsule. Relative or absolute reflectance from the eye, and optionally from a surgical contact lens, may be measured to confirm and optionally quantify the presence of the light absorbing agent, before the treatment beam is applied.

Abstract: A fundus camera and method of operating the fundus camera are described. The fundus camera includes an image sensor, an eyepiece lens, an illumination source, and an alignment target. The image sensor captures image light of a retina within an eye. The eyepiece lens is disposed to pass the image light of the retina to the image sensor. The illumination source is disposed to direct illumination light onto the retina through the eyepiece lens. The illumination source is further disposed around a first aperture through which the image light of the retina passes from the eyepiece lens to the image sensor. The alignment target is coupled to output an alignment image through the eyepiece lens to the eye and disposed around a second aperture through which the image light of the retina is passed to the image sensor and the illumination light is passed to the eyepiece lens.

Abstract: In some examples, a system may generate an alternating current signal to one of a first sensor electrode or a second sensor electrode. For instance, the first sensor electrode may be associated with a seatbelt and located adjacent to a torso of a vehicle operator of a vehicle. Further, the second sensor electrode may be positioned to be contacted by or otherwise proximate to another body part of the vehicle operator, such as at least one of an arm, hand, leg, or foot of the vehicle operator. The system may receive from the other one of the first sensor electrode or the second sensor electrode, a signal indicative of a capacitance, and may determine a respiration rate of the vehicle operator based at least partially on the signal indicative of the capacitance.

Abstract: Portable analytical equipment, systems, methods, and techniques related thereto is disclosed. Portable analytical equipment can comprise a controller and a probe. The probe can interrogate a sample and receive a response to the interrogation. The controller can select and/or initiate an analysis related to interrogating the sample via the probe. The analysis can be selected from a portfolio of analyses stored on the controller. The controller can analyze the response to the interrogation based on reference data stored on the controller. The controller can determine an indication based on the analyzing the response for presentation via a low-power interface, which can comprise an LED or electrophoretic element. The controller can further be connected to an external device, e.g., a smartphone or remote PC, to present collected data and the analyzing of the response to the interrogation. The disclosed subject matter can be employed in hand-held analytical equipment, e.g., a hand-held Raman spectrometer.

Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

Abstract: A technique for classifying lesions as malignant or benign is disclosed. The technique can include: cooling an area of skin including a lesion of a patient to initiate a warm-up process; receiving a temporal sequence of thermal images of the area of skin representing a thermal recovery of the area of skin, the temporal sequence of thermal images generated by an infrared camera; generating a temporal profile of the thermal recovery based on the temporal sequence of thermal images; analyzing temporal statistical properties of the temporal profile; determining a malignancy probability that the lesion is malignant based on an analysis of the temporal profile, wherein the determining includes extracting one or more statistical features based on continuous-time stochastic signals in the sequence of thermal images; and classifying the lesion based on the malignancy probability.

Abstract: An imaging system for an object such as human or animal tissue applies acoustic vibrations localized in two or three dimensions and simultaneously illuminates the object with an illuminating electromagnetic wave. A transmitter or receiver is provided that has an antenna with at least one coil that surrounds an axis along which at least a portion of the acoustic vibration is output.

Abstract: Disclosed are methods for imaging lumen-forming structures such as blood vessels using near-infrared fluorescence in the NIR-II region of 1000-1700 nm. The fluorescence is created by excitation of solubilized nano-structures that are delivered to the structures, such as carbon nanotubes, quantum dots or organic molecular fluorophores attached to hydrophilic polymers. These nanostructures fluoresce in the NIR-II region when illuminated through the skin and tissues. Fine anatomical vessel resolution down to ?30 ?m and high temporal resolution up to 5-10 frames per second is obtained for small-vessel imaging with up to 1 cm penetration depth in mouse hind limb, which compares favorably to tomographic imaging modalities such as CT and MRI with much higher spatial and temporal resolution, and compares favorably to scanning microscopic imaging techniques with much deeper penetration.

Abstract: Laser assisted cataract surgery methods and devices utilizing one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may optionally be added onto or into the lens capsule tissue, and the treatment laser wavelength selected to be strongly absorbed by the light absorbing agent. Alternatively, the treatment laser wavelength may be selected to be absorbed or strongly absorbed by the tissue itself, in which case no additional light absorbing agent need be used. Visualization patterns produced with one or more target laser beams may be projected onto the lens capsule tissue to aid in the procedure. The devices may be attached to or integrated with microscopes.

Abstract: According to one embodiment, the present invention relates to (1) a sensor system configuration to record multi-level spatial and spectral information for creating high spatial resolution, large coverage, and high spectral resolution (hyperspectral) images, and (2) a multi-level spatial and spectral resolution sharpening method to create high spatial resolution, large coverage hyperspectral images.

Abstract: The present invention includes a method for biomimetic-inspired infrared sensors utilizing a bottom up approach. This method includes providing a sinusoidal alternating electrical field between a preformed electrode gap comprising two gold micro-electrodes. Providing single needles of zinc phosphide crystals optimized for growth conditions using a physical vapour transport. Immobilizing at least one individual zinc phosphide nanowire in the preformed electrode gap using dielectrophoretic manipulation. And, placing and contacting the at least one individual zinc phosphide nanowire in the preformed electrode gap. Two nanowires are combined to form a lambda shape for improved sensing.

Abstract: Laser assisted cataract surgery methods and devices utilizing one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may optionally be added onto or into the lens capsule tissue, and the treatment laser wavelength selected to be strongly absorbed by the light absorbing agent. Alternatively, the treatment laser wavelength may be selected to be absorbed or strongly absorbed by the tissue itself, in which case no additional light absorbing agent need be used. Visualization patterns produced with one or more target laser beams may be projected onto the lens capsule tissue to aid in the procedure. The devices may be attached to or integrated with microscopes.

Abstract: A monitoring device having at least one data processing unit, at least one transmitter and/or receiver unit, at least one acceleration sensor, and can be connected to at least one sensor for recording measured values, wherein the data processing unit has at least two operating modes, including a “basic mode” and a “base station mode”, wherein: in the “basic mode”, the measured values of the acceleration sensor and/or of the at least one sensor are monitored, in the “base station mode”, the measured values can be processed by at least one other but compatible monitoring device in the “basic mode”. The invention also relates to a monitoring system.

Abstract: A wearable system configured to collect thermal measurements related to respiration. The system includes a frame configured to be worn on a user's head, and at least one non-contact thermal camera (e.g., thermopile or microbolometer based sensor). The thermal camera is small and lightweight, physically coupled to the frame, located close to the user's face, does not occlude any of the user's mouth and nostrils, and is configured to take thermal measurements of: a portion of the right side of the user's upper lip, a portion of the left side of the user's upper lip, and a portion of the user's mouth. The thermal measurements are forwarded to a computer that calculates breathing related parameters, such as breathing rate, an extent to which the breathing was done through the mouth, an extent to which the breathing was done through the nostrils, and ratio between exhaling and inhaling durations.

Abstract: A hybrid system is developed using thermal and electrical impedance imaging methods together. The innovation of the approach relies on the frequency dependence of the tissue's electrical impedance which facilitates the acquisition of multiple thermal images with currents at different frequencies injected to the region of the body under inspection. Proposed method without current application (in passive mode of operation) provides images which are obtained by standard thermal imagers. On the other hand, the application of the electrical current (in active mode of operation) increases the temperature contrast on the body surface depending on the electrical property of tissue. Therefore, the technique while increasing the thermal contrast provides frequency dependent conductivity distribution data which can be used as a basis for the detection of the breast carcinoma. The sensitivity of the technique is increased by an infrared camera with dual band (MWIR/LWIR) imaging capability.

Abstract: Methods and apparatus for optically recognizing tissue parameters during an energy-based tissue-sealing procedure involve grasping tissue with a tissue-sealing instrument, illuminating the grasped tissue or tissue adjacent to the grasped tissue with light, analyzing the light that is transmitted, scattered, or reflected by the tissue, and recognizing the tissue based on the result of analyzing the light. The wavelength of the light may be selected so that a vessel is sufficiently recognizable in tissue containing the vessel. A marker may also be introduced into fluid flowing in the vessel to increase the contrast between the vessel and tissue containing the vessel. Analyzing the light includes analyzing the spatial and spectral distribution of light. Analyzing the light may also include forming the light into an image of the illuminated tissue.

Abstract: The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

Abstract: Methods are provided for monitoring and controlling tissue ablation using RF energy delivered by an imaging ablation catheter under direct visualization, using the control and modulation of a set of ablation parameters based on direct optical imaging of the tissue surface via the imaging ablation catheter, where a set of optical image-derived parameters modulates the setting of a subset of Radio Frequency dosing parameters. The ablation dosing algorithms based on image-derived information can be implemented manually or in semi-automated or automated forms.

Abstract: Systems and methods for imaging an eye are disclosed. The systems and methods may include at least one plenoptic camera. The systems and methods may include an illumination source with a plurality of lights.

Abstract: Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.

Abstract: Systems, methods and devices for reducing noise in health monitoring including monitoring systems, methods and/or devices receiving a health signal and/or having at least one electrode or sensor for health monitoring.

Abstract: A calibration method for a hand-held surgical instrument is disclosed. The hand-held instrument includes a drive motor, a firing rod controlled by the drive motor and having at least one indicator, and a sensor configured to detect the at least one indicator. A microcontroller includes a pulse modulation algorithm stored therein to control the drive motor. The microcontroller executes a calibration algorithm to adjust at least one program coefficient in the pulse modulation algorithm.

Abstract: A system for the endoscopic X-ray luminescence computed tomographic imaging is provided.

Abstract: The present application discloses a novel algorithm to convert medical hyperspectral images (MHSI) into RGB (RedBlueGreen) images in different medical conditions by making use of the three spectral bands (Red, Green and Blue) of the MHSI and mapping them into Red, Green and Blue components for visualization of hyperspectral images.

Abstract: A surgical instrument for use by an operator in a surgical procedure includes an elongate shaft, an end effector extending from the elongate shaft, and a control system. The end effector is articulatable relative to the elongate shaft between a home state position and an articulated position. The control system includes a processor and a memory coupled to the processor to store program instructions. The processor can alert the operator when the end effector reaches the home state position from the articulated position.

Abstract: A method for capturing and consolidating multi-spectral image data for regions of interest using one or more spectral boost mechanisms or techniques is disclosed. A first multi-spectral or hyperspectral workflow comprising time-stamped two-dimensional pixelated images of a region of interest is obtained by a first computer-enabled imaging device. Each of the images corresponds to image data captured for a respective frequency band of a plurality of frequency bands. First meta data is associated with the images of the first workflow and includes: a plurality of first positions and first orientations of the first imaging device indicating first positional and orientation data for the first imaging device, and indications of a respective frequency band for each of the images of the first workflow. A consolidated multi-spectral workflow for the region of interest is generated, which includes spectrally and spatially consolidating the images of the first workflow using the first meta data.

Abstract: A remote photoplethysmography system includes a filter (10) for application to a detection unit. The filter further includes a first filter area (11) configured to transmit light (A) at a first wavelength and a second filter area (12) configured to transmit light (D) at a second wavelength. The detection unit (22) detects radiation received from the first filter area and from the second filter area of the filter. An analysis unit (6) determines the vital sign information of the subject from the detected radiation from the first filter area and from the second filter area.

Abstract: In general, the disclosure is directed toward an implantable medical device that includes a plurality of sensor modules that are implanted within a patient. The sensor modules may cooperate with each other to coordinate the timing for performance of one or more sensor actions across the modules when making a measurement. Example measurements include tissue perfusion measurements, oxygen sensing measurements, sonomicrometry measurements, and pressure measurements. The coordination of the sensor modules may be controlled by a signal that is transmitted from a host controller to the sensor modules via a bus. In some examples, the bus may have two wires that transmit both timing information and data information to the sensor modules. The signal may be a signal that is substantially periodic, such as a pulsed signal. In additional examples, the signal may supply operating power and timing information to the sensor modules.

Abstract: The present invention provides compositions comprising extracts of Jojoba (Simmondsia chinensis) in a polar solvent that are effective in promoting the barrier functions of the skin, useful for improving skin integrity, health and appearance and as anti-aging agent.

Abstract: The present invention aims to provide a refractometer that can satisfactorily observe an actual state of measurement light during a measurement with low cost. A graph 311 showing detection intensity of measurement light detected by a detector and a captured image 312 by a camera are displayed on one display screen 301 in real time. This configuration eliminates the need to separately provide a display unit for displaying the captured image 312 by the camera, thereby reducing cost. In addition, the actual state of measurement light can satisfactorily be observed during the measurement through the confirmation of the captured image 312 by the camera displayed on one display screen 301 along with the graph 311 in real time.

Abstract: A system includes a wrist computer and a portable video camera. The wrist computer acquires physical activity data measured by a sensor device, generates a time marker on the basis of the physical activity data, and transmits the time marker to the portable video camera according to a predefined wireless communication protocol. The portable video camera is configured to record video data, encode the video data into a video data file, and store the received time marker as meta data in the video file.

Abstract: Embodiments of the present disclosure disclose a method and system for determining health condition of a subject. First step of the method comprises receiving, by a computing unit, a first oxygen saturation level and a second oxygen saturation level from at least two sensors placed on the subject. Second step of the method comprises determining cerebral extraction of oxygen using the first and second oxygen saturation levels. Third step of the method comprises comparing the cerebral extraction of oxygen with a threshold level. Fourth step of the method comprises identifying a mental fatigue level of the subject based on outcome of the comparison, wherein the mental fatigue level indicates the health condition of the subject.

Abstract: A motion-compensated cutting system includes a hand-held tool body, and an actuator connected to the tool body. A shaft of the actuator is movable relative to the tool body so that a distal end of a cutting implement attached to the shaft is axially movable relative to the tool body. An optical coherence tomography system includes an optical fiber with a distal end fixed relative to the distal end of the cutting implement. The system includes a control unit that can determine a position of the distal end of the cutting implement relative to a reference surface based on input from the optical coherence tomography system. The control unit can control the cutting implement to compensate for relative motion between the tool body and the reference surface, and can maintain a predetermined depth of the distal end of the cutting implement with respect to the reference surface.

Abstract: The subject invention includes a biomimetic integrated optical sensor system, based on the integration of a wide field-of-view (WFOV) miniature staring multi-aperture compound eye with a high-speed, low-cost, polarization and spectral selective liquid crystal (LC) filter array, a MWIR focal plane array (FPA), and a neural network processor.

Abstract: Methods and systems for characterizing tissue of a subject are disclosed. The method includes receiving a time series of fluorescence images of the tissue of the subject wherein the images define a plurality of calculation regions, generating a plurality of time-intensity curves for the plurality of calculation regions, creating a set of parameter values for each calculation region, generating a total rank value for each calculation region by comparing the sets of parameter values, and converting the total rank value into a ranking map image. Also disclosed are methods and systems for characterizing a wound in tissue by generating a wound index value.

Abstract: An apparatus for turbid sample measurement comprising a plurality of light sources for illuminating a turbid sample target area with non-spatial structured light, a projection system for illuminating the turbid sample target area with spatial structured light, a sensor for collecting light from the turbid sample target area, and a processor to analyze the data captured by the sensor to yield scattering and absorption coefficients of the turbid sample. A method comprises illuminating the sample with spatial structured light, collecting light reflected from the sample at a number of wavelengths, illuminating the sample with non-spatial structured light, collecting light reflected from the sample at a number of wavelengths, and combining the measurements of the collected light to obtain the optical properties of the sample and/or the concentration of absorbing or fluorescent molecules. The wavelengths of the spatial and non-spatial light sources are preferably different.

Abstract: Provided is an image forming apparatus that forms a layer of at least one type of scattering material. The image forming apparatus is configured to obtain subsurface scattering characteristic data indicating the subsurface scattering characteristic of a reproducing target, and determine the laminated structure of the layer of the scattering material based on the subsurface scattering characteristic data. The image forming apparatus is configured to then form an image corresponding to the layer of the scattering material based on the determined laminated structure of the layer of the scattering material.

Abstract: fNIRS may be used in real time or near-real time to detect the mental state of individuals. Phase measurement can be applied to drive an adaptive filter for the removal of motion artifacts in real time or near-real time. In this manner, the application of fNIRS may be extended to practical non-laboratory environments. For example, the mental state of an operator of a vehicle may be monitored, and alerts may be issued and/or an autopilot may be engaged when the mental state of the operator indicates that the operator is inattentive.

Abstract: A protective guide for protecting a cell extraction device used during a Pap smear. An access tunnel receives the cell extraction device and allows for access and movement of the cell extraction device. A protective chamber covers and protects the head of the cell extraction device as the cell extraction device is being removed and inserted from the patient's vagina. A protective guide connector attaches the protective guide to an imaging transducer. After inserted into the patient's vagina, the location of the patient's cervix is determined by utilization of the imaging transducer. Once the cervix is located the cell extraction device is pushed outward from the protective chamber so that the cell extraction device head contacts the cervix and then removes cells from the cervix. The cell extraction device head is then pulled back into the protective chamber and the protective guide is removed from the patient's vagina.

Abstract: Laser assisted cataract surgery methods and devices utilizing one or more treatment laser beams to create a shaped opening in the anterior lens capsule of the eye when performing a capsulorrhexis procedure. A light absorbing agent may optionally be added onto or into the lens capsule tissue, and the treatment laser wavelength selected to be strongly absorbed by the light absorbing agent. Alternatively, the treatment laser wavelength may be selected to be absorbed or strongly absorbed by the tissue itself, in which case no additional light absorbing agent need be used. Visualization patterns produced with one or more target laser beams may be projected onto the lens capsule tissue to aid in the procedure. The devices may be attached to or integrated with microscopes.