Abstract: Electrophysiology mapping and visualization systems are described herein where such devices may be used to visualize tissue regions as well as map the electrophysiological activity of the tissue. Such a system may include a deployment catheter and an attached hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. A position of the catheter and/or hood may be tracked and the hood may also be used to detect the electrophysiological activity of the visualized tissue for mapping.

Abstract: Implementations disclosed herein provide a monitoring technology. In one implementation, a monitoring system measures whole body biometric levels by analysis of changes in vascular volume caused by pulsatile pressure waves and in tissue volume in response to the pulsatile pressure. The monitoring system includes a monitoring device, which uses a light-based measurement technique to measure biometric levels during different activities and at rest. A light source operatively connected to a light sensor, transmits light, reflectively or transmissively, through tissue. The light sensor detects absorption of the light. Based on wavelength measurements of the detected light, the monitoring device produces a PPG waveform representing characteristic effects of certain physiological parameters. In one implementation, operating contexts are sensed in a monitoring device. A monitoring profile is selected based on the sensed operating contexts.

Abstract: Implementations disclosed herein provide a hydration monitoring technology. In one implementation, a hydration monitoring device measures whole body hydration levels by analysis of changes in vascular volume caused by pulsatile pressure waves and in tissue volume in response to the pulsatile pressure. The hydration monitoring device uses a light-based measurement technique to transmits light, reflectively or transmissively, through tissue. Based on wavelength measurements of the detected light, the hydration monitoring device produces a PPG waveform representing characteristic effects of hydration. The hydration monitoring device monitors operating condition signals associated with the hydration monitoring device. By monitoring operating condition signals, the hydration monitoring device determines whether the operating condition signals satisfy an analysis condition, and modifies the optical sensing operations.

Abstract: Implementations disclosed herein provide a monitoring technology. In one implementation, a monitoring system measures whole body biometric levels by analysis of changes in vascular volume caused by pulsatile pressure waves and in tissue volume in response to the pulsatile pressure. The monitoring system includes a monitoring device, which uses a light-based measurement technique to measure biometric levels during different activities and at rest. A light source operatively connected to a light sensor, transmits light, reflectively or transmissively, through tissue. The light sensor detects absorption of the light. Based on wavelength measurements of the detected light, the monitoring device produces a PPG waveform representing characteristic effects of certain physiological parameters. PPG pulse data is selected that satisfies a data integrity condition. Based on analysis of the selected PPG pulse data, the monitoring device computes a biometric.

Abstract: Implementations disclosed herein provide a hydration monitoring technology. In one implementation, a hydration monitoring system measures whole body hydration levels by analysis of changes in vascular volume caused by pulsatile pressure waves and in tissue volume in response to the pulsatile pressure. The hydration monitoring system includes a hydration monitoring device, which uses a light-based measurement technique to measure hydration levels and heart rate during different activities and at rest. In one implementation, a light source operatively connected to a light sensor, transmits light, reflectively or transmissively, through tissue. The light sensor detects absorption of the light. Based on wavelength measurements of the detected light, the hydration monitoring device produces a PPG waveform representing characteristic effects of hydration. Based on analysis of the PPG waveform, the hydration monitoring device determines a hydration metric representative of hydration levels in the body.

Abstract: An OCI medical device includes a coherent light source, a light sensor, a first processing unit adapted to calculate OCI Data from the light sensor, a control unit which allows taking or loading of at least one Reference OCI Value, a second processing unit adapted to calculate the Intra-Individual Relative Assessment of the OCI Data of an Imaging Zone and the at least one OCI Reference Value, and display means adapted to show at least one Relative OCI Value. Uses and a method for assessing the blood flow of a body region use OCI imaging and include an Intra-Individual Relative Assessment between OCI Data of the Imaging Zone and at least one Reference OCI Value.

Abstract: Described herein are methods for determining a target musculoskeletal activity cycle (MSKC) to cardiac cycle (CC) timing relationship. The method may include detecting a first characteristic of a signal responsive to a CC timing of a user that repeats at a frequency that corresponds to a heart rate of the user; detecting a second characteristic of a signal responsive to a rhythmic musculoskeletal cycle activity (MSKC) timing of the user that repeats at a frequency that corresponds to the MSKC rate of the user; determining a value representative of an actual timing relationship between the first characteristic and the second characteristic; detecting a third characteristic of a signal corresponding to a physiological metric that varies with the actual timing relationship between the first and second characteristics; and determining a target value representative of a preferred timing relationship between the first and second characteristics.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Disclosed herein are systems and methods for revascularization assessment. The methods can in some cases include one or more of the steps of measuring blood perfusion as a function of time to obtain time series data, mathematically transforming the time series data into a power spectrum, calculating at least one parameter of the power spectrum within a specific frequency range, and using the at least one calculated parameter as a discriminator for the first population and the second population.

Abstract: A system is provided including a thoracic bio-impedance or bio-reactance (TBIR) analysis module, a photoplethysmograph (PPG) analysis module, and a cardiac output module. The TBIR module is configured to obtain TBIR information from a TBIR detector, and the PPG analysis module is configured to obtain PPG information from a PPG detector. The cardiac output module is configured to determine the cardiac output of a patient using the TBIR information and the PPG information.

Abstract: What is disclosed is a video-based system and method for estimating heart rate variability from time-series signals generated from video images captured of a subject of interest being monitored for cardiac function. In a manner more fully disclosed herein, low frequency and high frequency components are extracted from a time-series signal obtained by processing a video of the subject being monitored. A ratio of the low and high frequency of the integrated power spectrum within these components is computed. Analysis of the dynamics of this ratio over time is used to estimate heart rate variability. The teachings hereof can be used in a continuous monitoring mode with a relatively high degree of measurement accuracy and find their uses in a variety of diverse applications such as, for instance, emergency rooms, cardiac intensive care units, neonatal intensive care units, and various telemedicine applications.

Abstract: Disclosed herein is a method for obtaining a value of at least one vasodilation parameter representing the cutaneous local thermal hyperemia response of a subject. The temperature of a sampling site is raised from a first temperature to a second temperature and maintained for an initial heating period, and an initial maximum red blood cell flux (RBCF) of the sampling site and a mean arterial pressure of the subject is obtained. An initial maximum cutaneous vascular conductance (CVC1,max) is calculated by dividing the initial maximum RBCF by the mean arterial pressure. The CVC1, max or at least one other parameter derived therefrom is used as the vasodilation parameter.

Abstract: A pulse wave measuring device includes: a connector that is disposed on a main unit; an external sensor that includes an external light-emitting module radiating light to a human body to be measured and an external light-receiving module receiving at least one of reflected light and transmitted light originating from the external light-emitting module and the human body so as to measure a pulse wave; an first controller that switches the external light-emitting module ON and OFF; an second controller that switches the external light-receiving module ON and OFF; and an external sensor connection determination section that determines a connection between the external sensor and the connector in accordance with a transient response of the external light-receiving module, wherein, after the external sensor connection determination section determines that the external sensor is connected to the connector, a measurement of the pulse wave by using the external sensor is started.

Abstract: A Photoplethysmography-based sensor for measuring heart rate is provided herein. The sensor may include a first light source and a second light source configured to illuminate a body tissue by a first light and a second light respectively; and a first and a second light detectors, each configured to detect light comprising portions of said first light and of said second light, transferred through the body tissue; and a processor with an analog measurement part configured to: receive light intensity readings of at least a portion of light as sensed by each one of both sensors and coming from each one of both sources; and calculate a measure of tissue absorption based on ratios of light portions transmitted by each one of both sources and measured by each one of both detectors.

Abstract: In accordance with one aspect of the present technique, a method is disclosed. The method includes receiving continuous photoplethysmographic (PPG) data of a subject from a sensor and calculating a continuous blood characteristic (BC) based on the continuous PPG data. The method also includes calculating a first quality metric of the continuous PPG data based on a sequence of the continuous BC. The method further determines whether the first quality metric satisfies a stability criterion and sending a first notification to the sensor in response to determining that the first quality metric satisfies the stability criterion. The first notification instructs the sensor to collect compressed PPG data of the subject.

Abstract: An optical biometric system (1) is characterized by being provided with: a first received light amount information acquisition unit (25) which acquires skin blood flow data relating to a skin blood flow in a wide range of the scalp of a subject by controlling the transmission/reception of light to/from a light transmission/reception unit (30) using a wide-range control table; and a selection control table creation unit (24) which causes a storage unit (23) to store a selection control table for acquiring X pieces of first received light amount information (?A1) selected from among N pieces of first received light amount information (?A1), and in that when acquiring multiple pieces of measurement data relating to the brain activity in a predetermined range of the brain of the subject by controlling the transmission/reception of light to/from the light transmission/reception unit (30) using a control table, a light transmission/reception control unit (21) acquires skin blood flow data relating to a skin blood f

Abstract: Method of determining atrial fibrillation including determining if a patient's pulse beats form an irregular pattern and only if so, indicating the presence of an irregular pulse to the patient and obtaining an electrocardiogram for determining atrial fibrillation. Initially, a pulse is detected at regular time intervals of a first appendage of the patient when motionless using a pulse detector secured to the first appendage and pulse rhythms from a succession of time intervals are detected each corresponding to a respective interval of time between successive pulse beats of a sequence of the pulse beats. Then, an electrically conductive unit is attached to a second appendage of the patient, or a wearable electrocardiogram is attached to the patient, and electrocardiograms signals are detected simultaneously with pulse rhythms while the first appendage is motionless and analyzed to determine whether, in combination, they are indicative of atrial fibrillation.

Abstract: What is disclosed is a system and method for estimating minute ventilation by analyzing distortions in reflections of structured illumination patterns captured in a video of a thoracic region of a subject of interest being monitored for respiratory function. Measurement readings can be acquired in a few seconds under a diverse set of lighting conditions and provide a non-contact approach to patient respiratory function that is particularly useful for infant care in an intensive care unit (ICU), sleep studies, and can aid in the early detection of sudden deterioration of physiological conditions due to detectable changes in chest volume. The systems and methods disclosed herein provide an effective tool for non-contact minute ventilation estimation and respiratory function analysis.

Abstract: A physiological information measuring apparatus includes a first detection unit, having a first light emitting unit and a first light receiving unit, separated from one another by a first distance. A second detection unit of the physiological information measuring apparatus has a second light emitting unit and a second light receiving unit, separated from one another by a second, different distance. Alternatively, the second detection unit shares the first light emitting unit with the first detection unit and has a second light receiving unit. Alternatively, the second detection unit shares the first light receiving unit with the first detection unit and has a second light emitting unit. A measuring unit of the physiological information measuring apparatus measures the physiological information of a user based on light received by the light receiving unit or light receiving units.

Abstract: A near infrared spectrophotometric (NIRS) sensor assembly for non-invasive monitoring of blood oxygenation levels in a subject's body is provided that includes a pad, at least one light source, a near light detector, a far light detector, and a cover. The light source is operative to emit near infrared light signals of a plurality of different wavelengths. The near light detector is separated from the light source by a first distance that is great enough to position the first light detector outside of an optical shunt field extending out from the light source. The far light detector is substantially linearly aligned with the near light detector and light source, and is separated from the near light detector by a second distance, wherein the second distance is greater than the first distance.

Abstract: What is disclosed is a system and method for performing a medical diagnosis for a subject of interest using a RGB video camera and a spot radiometer in a non-contact, remote sensing environment. In one embodiment, video images are captured using a RGB video camera in real-time of a subject of interest for medical diagnostic purposes. The video images are analyzed to identify a region of exposed skin for which measurements are desired to be obtained. A relative position of a spot radiometer is then adjusted such that the spot radiometer can measure incident radiation at a desired wavelength range from the identified region of exposed skin. The measurements are then used to perform a medical diagnosis for the subject. Various embodiments are disclosed.

Abstract: Exemplary method, computer-readable medium and system can be provided for generating at least one information associated with at least one signal and/or data received from at least one structure. For example, it is possible to determine at least one basis based on a combination of a plurality of portions of the signal(s) and/or the data. It is also possible to generate the information(s) as a function of the basis.

Abstract: A biological information detector includes a wristband, a light-emitting part, a reflecting part, a light-receiving part, a protecting part, an acceleration sensor and a processing part. The wristband is adapted to be attached to a body of a user. The light-emitting part is configured to emit green light. The reflecting part is configured to reflect the light emitted by the light-emitting part. The light-receiving part is configured to receive reflected light reflected at a detection site of the body of the user. The protecting part is configured to protect the light-emitting part, the protecting part having a contact surface configured to contact with the detection site. The acceleration sensor is configured to detect acceleration generated by the user. The processing part is configured to process a light reception signal outputted from the light-receiving part.

Abstract: A system and method for hemodynamic dysfunction detection may include at least one sensor configured to received one or more signals from a patient, a computing device in data communication with the at least one sensor, a computer-readable storage medium in communication with the computing device, an input device, and an output device. The system may include computer readable instructions to cause the system to receive at least one signal in the time domain from the sensor, determine at least one metric in the frequency domain from the at least one signal in the time domain, and determine the cardiovascular state of the patient from a combination of the at least one metric in the frequency domain and information contained in at least one database of cardiovascular states. The system may also notify a user of a immanent patient cardiovascular event and recommend one or more interventions to mitigate it.

Abstract: The present inventions, in one aspect, are directed to portable biometric monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, at least one band to secure the monitoring device to the user, a physiological sensor, disposed in the housing, to generate data which is representative of a physiological condition of the user data. The physiological sensor may include a light source to generate and output light having at least a first wavelength, and a photodetector to detect scattered light (e.g., from the user). A light pipe is disposed in the housing and optically coupled to the light source directs/transmits light therefrom along a predetermined path to an outer surface of the housing. Processing circuitry calculates a heart rate of the user using data which is representative of the scattered light.

Abstract: There is provided a wearable item configured to be placed at least partially against a skin of a person; and an optically sensitive detector mounted to the wearable item and configured to detect optical signals reflected from the skin of the person, wherein the detected optical signals represent a relative motion between the wearable item and the skin of the person and wherein the optically sensitive detector is mounted to the wearable item such that there is a predetermined space between the optically sensitive detector and the skin of the person.

Abstract: Systems and methods for detecting a worsening of patient's heart failure condition based, at least in part, on an increasing trend in a representative rapid shallow breathing index (RSBI) value over multiple days. The RSBI value may be a minimum RSBI, and more particularly may be a minimum RSBI value determined for an afternoon portion of each of the multiple days. The minimum RSBI value measured during an afternoon portion of the day may be more sensitive to changes in a patient's respiration, particularly when a patient is expected to be more active, and thus, may more readily exhibit an increasing trend when patient's heart failure is in decline.

Abstract: A physiological monitoring system may receive a sensor signal from a physiological sensor. The system may generate an estimate of the sensor signal based on, for example, prior received signals. The estimate signal may be subtracted from the sensor signal using a transimpedance amplifier to generate a difference signal. A gain and/or offset may be applied to the difference signal by the amplifier. The amplified difference signal may be digitized and combined with the estimate signal to generate a high resolution digital representation of the sensor signal. Physiological information such as blood oxygen saturation, pulse rate, respiration rate, respiration effort, blood pressure, hemoglobin concentration, any other suitable physiological parameters, or any combination thereof, may be determined using the digitized sensor signal.

Abstract: A method for monitoring physiological parameters associated with a subject using a hand held device is described herein. In an implementation, the method includes obtaining a plurality of sample photoplethysmographic (PPG) features associated with a sample subject, from a video of a body part of the sample subject. From among the plurality of sample PPG features, at least one relevant sample PPG feature associated with the physiological parameter, is selected based on a ground truth value of the physiological parameter for the subject. Further, based on the at least one relevant sample PPG feature and the ground truth value of the physiological parameter, a mathematical model indicative of a correlation between the relevant sample PPG feature and the physiological parameter, is determined. The mathematical model can be deployed for monitoring the physiological parameter in real time.

Abstract: Some embodiments provide a wearable fitness monitoring device including a motion sensor and a photoplethysmographic (PPG) sensor. The PPG sensor includes (i) a periodic light source, (ii) a photo detector, and (iii) circuitry determining a user's heart rate from an output of the photo detector. Some embodiments provide methods for operating a heart rate monitor of a wearable fitness monitoring device to measure one or more characteristics of a heartbeat waveform. Some embodiments provide methods for operating the wearable fitness monitoring device in a low power state when the device determines that the device is not worn by a user. Some embodiments provide methods for operating the wearable fitness monitoring device in a normal power state when the device determines that the device is worn by a user. Some embodiments provide methods for using response characteristics of the user's skin to adjust a gain and/or light emission intensity of the heart rate monitor.

Abstract: The present disclosure provides a method and system for stimulating and monitoring intensity of pain experienced by one or more users. The method includes measuring the intensity of pain experienced by the one or more users on a pre-determined scale and augmented chart or physician's personal assessment using a plurality of one or more bio-markers, determining co-relation between the plurality of one or more bio-markers and the intensity of pain experienced by the one or more users, refining the co-relation between the plurality of one or more bio-markers and the intensity of pain experienced by the one or more users by learning from responses of one or more similar users, generating a pain profile for each of the one or more users and utilizing the learned information and the generated profile for monitoring, evaluating and treating the one or more users.

Abstract: Some embodiments provide a wearable fitness monitoring device including a motion sensor and a photoplethysmographic (PPG) sensor. The PPG sensor includes (i) a periodic light source, (ii) a photo detector, and (iii) circuitry determining a user's heart rate from an output of the photo detector. Some embodiments provide methods for operating a heart rate monitor of a wearable fitness monitoring device to measure one or more characteristics of a heartbeat waveform. Some embodiments provide methods for operating the wearable fitness monitoring device in a low power state when the device determines that the device is not worn by a user. Some embodiments provide methods for operating the wearable fitness monitoring device in a normal power state when the device determines that the device is worn by a user.

Abstract: What is disclosed is a method for monitoring a subject for cardiac arrhythmia such as atrial fibrillation using an apparatus that can be comfortably worn by the subject around an area of exposed skin where a photoplethysmographic (PPG) signal can be registered. In one embodiment, the apparatus is a reflective or transmissive wrist-worn device with emitter/detector pairs fixed to an inner side of a band with at least one illuminator emitting source light at a specified wavelength band. The illuminator is paired to a respective photodetector comprising one or more sensors that are sensitive to a wavelength band of its paired illuminator. The photodetector measures intensity of sensed light emitted by a respective illuminator. The signal obtained by the sensors comprises a continuous PPG signal. The continuous PPG signal analyzed for peak-to-peak pulse points from which the existence of cardiac arrhythmia such as atrial fibrillation event can be determined.

Abstract: According to some aspects, the invention relates to methods and compositions for evaluation of hemodynamic responses (e.g., using molecular imaging) with high sensitivity.

Abstract: A system comprising a biometric monitoring device including a housing including a platform to receive at least one foot of the user, a body weight sensor to generate body weight data, processing circuitry to calculate user weight data which corresponds to the user's weight, using the body weight data, and communication circuitry to: (a) receive user identification data which identifies the user or a portable activity monitoring device, and (b) transmit the user weight data to data storage associated with the user identification data. The system further includes the portable activity monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, a sensor to generate sensor data, and communication circuitry to receive physiologic data which is based on the user weight data, and processing circuitry to calculate activity data using the sensor data and physiologic data.

Abstract: Methods and apparatus disclosed herein use a filtering technique to improve the accuracy of the results achieved when processing data provided by a physiological sensor. The disclosed filtering technique corrects many of the accuracy problems associated with physiological sensors, particularly PPG sensors. Broadly, the filtering technique adjusts a current filtered estimate of a physiological metric as a function of a rate limit based on a comparison between an instantaneous estimate of the physiological metric and the current filtered estimate.

Abstract: In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.

Abstract: Embodiments of a system and method for detecting a leading stroke risk indicator using low-cost, non-contact visual computing methods are generally described herein. In some embodiments, a video camera is arranged to capture a video of a face of a subject to be evaluated for having a stroke risk indicator. A memory is provided for storing data. A processor is coupled to the memory and is arranged to analyze processed image data associated with the video of the face of the subject captured by the video camera. The processor is further arranged to determine whether the processed image data exhibits a leading indicator for carotid artery stenosis.

Abstract: Heart rates and beat lengths can be extracted from videos by measuring subtle head motion caused by the Newtonian reaction to the influx of blood at each beat. In an embodiment of the present invention, a method tracks features on the head and performs principal component analysis (PCA) to decompose their trajectories into a set of component motions. The method then selects a component that best corresponds to heartbeats based on its temporal frequency spectrum. Finally, the motion projected to this component is analyzed and peaks of the trajectories are identified, which correspond to heartbeats.

Abstract: A biological information detector includes a light-emitting part, a first connecting pad, a first bonding wire and a light transmission part. The first bonding wire electrically connects the light-emitting part and the first connecting pad. The light transmission part transmits light emitted by the light-emitting part. The light transmission part covers the light-emitting part and the first bonding wire.

Abstract: A system and method for identifying the location of a medical device within a patient's body may be used to localize the fossa ovalis for trans-septal procedures. The systems and methods measure light reflected by tissues encountered by an optical array. An optical array detects characteristic wavelengths of tissues that are different distances from the optical array. The reflectance of different wavelengths of light at different distances from an optical array may be used to identify the types of tissue encountered, including oxygenated blood in the left atrium as detected from the right atrium through the fossa ovalis.

Abstract: What is disclosed is a video system and method that accounts for differences in imaging characteristics of differing video systems used to acquire video of respective regions of interest of a subject being monitored for a desired physiological function. In one embodiment, video is captured using N video imaging devices, where N?2, of respective regions of interest of a subject being monitored for a desired physiological function (i.e., a respiratory or cardiac function). Each video imaging device is different but has complimentary imaging characteristics. A reliability factor f is determined for each of the devices in a manner more fully disclosed herein. A time-series signal is generated from each of the videos. Each time-series signal is weighted by each respective reliability factor and combined to obtain a composite signal. A physiological signal can be then extracted from the composite signal. The processed physiological signal corresponds to the desired physiological function.

Abstract: A biometric monitoring device having a heart rate sensor for measuring various biometric information is provided. In some embodiments, the biometric monitoring device allows the person to take and/or display a heart rate reading by a simple user interaction with the device, e.g., by simply touching a heart rate sensor surface area, moving the device in a defined motion pattern, or clenching the fist. Some embodiments of this disclosure provide a biometric monitoring device that allows a person to get a quick heart rate reading without removing the device or interrupting their other activities. Some embodiments provide heart rate monitoring with other desirable features such as feedback on data acquisition status.

Abstract: An example system can monitor the stress and fatigue of a subject. The system can include a light source configured to direct illuminating light onto a face of the subject. The illuminating light can reflect off the face of the subject to form reflected light. The system can include collection optics that collect a portion of the reflected light and produce video-rate images of the face of the subject. The system can include an image processor configured to locate an eye in the video-rate images, extract fatigue signatures from the located eye, and determine a fatigue level of the subject, in part, from the fatigue signatures. The image processor can also be configured to locate a facial region away from the eye in the video-rate images, extract stress signatures from the located facial region, and determine a stress level of the subject from the stress signatures.

Abstract: Provided is a technique for more accurately ascertaining a person's status. In particular, the present invention makes it possible to accurately ascertain the detection of alcohol or the like. A fluctuation waveform of an ultra-low-frequency band is found from a biosignal collected from a biosignal measuring means, the fluctuation waveform is plotted as coordinate points on a four-quadrant coordinate system on the basis of a predetermined standard, and biological status is estimated on the basis of temporal change in the coordinate points. According to the method of the present invention for plotting a fluctuation waveform as coordinate points on a four-quadrant coordinate system on the basis of the predetermined standard, change in the fluctuation waveform of the ultra-low-frequency band can be expanded or highlighted and thus perceived, and therefore the present invention is adapted for more accurately perceiving change in a person's status.

Abstract: A diagnostic system includes a plurality of semiconductor diodes, a multiplexer, and one or more waveguide structures to form an output beam. A lens system communicates some of the output beam onto a part of a user's body comprising blood to perform a measurement. A software application is capable of generating data based at least in part on the measurement, and it operates on a control system that may have a touch-screen, a proximity sensor, and a wireless transceiver to transmit wireless data over a wireless link. A host comprises a digital file, control logic at the host to process at least the portion of the wireless data to generate a status of the user, a memory storage device for recording the status, and an output for communicating at least a portion of the status or associated information over a communication link to one or more remote display output devices.

Abstract: An apparatus for detecting surface microcirculation of an acupoint includes an acupoint locator, a bio-optical blood flow detection device and a signal analysis processor. The acupoint locator includes an optical probe disposed therein and is configured to let the optical probe substantially align with and be in contact with a surface of the acupoint of a human subject. The bio-optical blood flow detection device is configured to capture microcirculation signals of the surface of the acupoint of the human subject by the optical probe. The signal analysis processor is configured to receive and analyze the microcirculation signals.

Abstract: A method for imaging blood flow through target tissue is disclosed. An example method may include (a) directing a light beam at a blood-perfused target tissue, (b) reflecting the directed light beam off of static target tissue and flowing cells, (c) capturing a plurality of digital images of interference patterns of the reflected light in a plurality of successive frames, (d) measuring a light intensity of at least one pixel of each digital image, where the at least one pixel corresponds to an identical pair of coordinates in each successive frame, (e) comparing the measured light intensity of the at least one pixel of each digital image to the measured light intensity of the at least one pixel of an adjacent frame at the identical pair of coordinates and (f) determining a compiled light intensity for the at least one pixel for an aggregate motion contrast.

Abstract: A biological information detector includes a light-emitting part, a first wiring, a first bonding wire and a protecting part. The light-emitting part is configured to emit a light. The first wiring includes a first connecting section. The first bonding wire electrically connects the light-emitting part and the first connecting section of the first wiring. The protecting part covers the light-emitting part, the first wiring and the first bonding wire. The protecting part is formed from a material that is transparent with respect to the light emitted by the light-emitting part.

Abstract: A sensor compares frames of pixels representing a speckle pattern caused by interference of light through an optical fiber to detect magnitudes of deflection of the fiber. A coherent light source illuminates the optical fiber. An image sensor captures the speckle pattern and frames of pixels produced by the image sensor are processed to determine deflection. A baseline frame is generated from frames previously received. Each frame is compared to the baseline frame to determine the cumulative amount of deflection on the fiber. To compensate for drift and large-scale movements of the optical fiber, the baseline frame is updated as frames are received. The processed output from comparing to the baseline frame has larger amplitude signals than from comparing to adjacent frames due to larger deflections over time since the baseline frame. Signal-to-Noise ratio is improved, and the processed output better matches a plot of the actual total deflection.