Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a manual switch for a user interface input.

Abstract: An injection device has a housing which includes a first housing part and a second housing part. The injection device has a receptacle for an injection needle. The receptacle is connected to a drive unit which moves the receptacle between proximal and distal end positions relative to the second housing part. The first housing part has a set piece for placing on the skin before triggering an injection. The first housing part is permanently fastened with respect to the second housing part. In a method for making the injection device, the first housing part is positioned on the second housing part so that the receptacle has a specified position relative to the set piece in the proximal end position thereof, and that the first housing part is permanently fastened in this position opposite the second housing part. A defined insertion depth can thus be ensured.

Abstract: A device for locating a cavity within two walls including a syringe including a syringe piston slideable in a first syringe barrel for discharging air or fluid contained in the first syringe barrel on forward movement of the syringe piston into the cavity, the first syringe barrel being attached to a hub of a needle cannula; and a frame which at least in part encases the syringe and which is solely connected to the back of the syringe piston.

Abstract: The present invention relates to an injection assistance device (1) comprising a body (2) with a needle (7), grasping means (4) and first elastic return means (9) to dampen limited movement of said grasping means (4), in at least one of the two directions, respectively distal or proximal, during an injection phase, and to maintain said body (2) in its insertion position and said needle (7) at a constant insertion length during the injection step, when the user increases, respectively releases, a distal pressure on the grasping means (4). The invention also relates to an injection set (100) comprising an injection device (3) and the said assistance device (1).

Abstract: A medicament injection device includes a device body portion that includes a penetrating member channel. A penetrating member is provided with a sharpened distal tip and shaft portion that is slidably disposed within the penetrating channel to provide for a penetrating to travel in a linear axial movement. A pierceable membrane isolates a penetrating member in an associated penetrating member chamber. A medicament reservoir is in fluid communication with the penetrating member. The medicament reservoir is configured to house a medicament and is coupled to the penetrating member to allow for delivery of medicament to a tissue site.

Abstract: The present disclosure provides a new and improved intravitreal injection device, which is capable of locating the injection site with precision and reproducibility, ensuring the smooth delivery of medications or other treatments, and reducing potential need contaminations. In various embodiments, the device comprises a head unit and a hollow stem extending orthogonally from a bottom of the head unit. The device additionally includes a locating foot slidingly disposed on a distal end of the stem and a biasing device structured to bias the locating foot toward an extended position.

Abstract: A catheter system includes a positioning catheter for receiving an injection needle into its lumen. The injection needle incorporates a web member mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the web member is biased to transition from a folded configuration, and into a flared configuration. Specifically, this transition occurs when the injection needle is deployed more than a predetermined distance “d” beyond the distal end of the catheter. In its flared configuration, the web member is disk-shaped and is oriented perpendicular to the needle. Thus, it acts as a barrier to limit the depth of insertion of the needle into target tissue of a patient, to a depth less than “d”, and to prevent perforation of the target tissue by the catheter tip.

Abstract: A drug delivery device including a needle assembly facilitates making intradermal injections using a variety of drug container types such as a syringe. A hub supports the needle while a limiter surrounds the needle. The limiter includes a skin engaging surface that is adapted to be received against the skin of an animal to be intradermally injected. A forward end of the needle extends beyond the skin engaging surface a selected distance to limit a depth that the needle penetrates into the animal's skin.

Abstract: A catheter stop includes an obstruction attached to a catheter at a location that represents the maximum acceptable insertion depth of the catheter into a tracheal tube without causing damage to a patient or the tube. In one embodiment, the obstruction is a pad having a pair of opposing adhesive wings for securing the pad to the catheter. In another embodiment, the obstruction is formed of a triangular housing having a pair of hinged sections that open and close in a clamshell-type fashion. Each section includes a longitudinal, semi-cylindrical, bore that cooperates with the bore on the other section to form a tubular passageway for accommodating the catheter when the sections are closed. A clamp on an edge of one section detachably engages a latch on the corresponding edge of the other section to secure the housing about the catheter.

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: Method and surgical instrument for treating prostate tissue including a surgical instrument having a main body, a needle deployment port, a needle, first and second handles and a lockout release mechanism to limit needle extension. Additionally, a kit includes the surgical instrument, together with a cystoscope, and optionally a syringe and reservoir of ethanol. The method includes needle-less injection and visualizing the ethanol injection by delivering both an echogenic agent and ethanol either by needle or needle-less injection or by providing an ultrasonically visible marker near the tip of the ethanol delivery cannula. The method also includes extending the needle transversely of the instrument housing using a link assembly.

Abstract: To securely position a needle tip and a blade face of a needle tube inserted into the skin in a predetermined site of a living body, such as the upper layer of skin, an injection needle assembly includes a needle tube having a needle tip capable of puncturing a living body, a hub holding the needle tube, a stabilizer, and a guide portion. The stabilizer is formed in a tubular shape surrounding the circumference of the needle tube, and an end face is pressed against the skin, and thereby a raised portion of the skin is formed in a tube hole. The guide portion is arranged on the stabilizer, and is adapted to recognize a press-in distance y of the stabilizer to the skin.

Abstract: Apparatus for use with tissue (22) of a subject, including a substance (24) configured to be injected into the tissue, and first and second tissue-squeezing surfaces (20) configured to be placed on first and second sides of the tissue, to exert pressure on the tissue by being moved toward each other in response to a squeezing force (F), and to facilitate injection of the substance into the tissue by releasing the substance in response to application of the squeezing force.

Abstract: A fluid vessel insertion device (10), typically for medical use, comprises a puncture member (18) arranged for location within a sleeve (20), and a retraction mechanism (44, 48, 60) for retracting the puncture member relative to the sleeve. The puncture member (18) is retractable in use between a first condition in which an end (18A) of the puncture member protrudes beyond an end (24) of the sleeve and a second condition in which the end of the puncture member is within the sleeve (20). The retraction mechanism (44, 48, 60) actuates the puncture member between the first and second conditions in response to fluid pressure at the end (18A) of the puncture member. The device may be used during positioning of the sleeve in a desired fluid vessel, such as, for example, during intravenous cannulation.

Abstract: A method and apparatus are provided for a fluid level insertion indicator that provides immediate feedback to a surgeon by draining when a tip of a needle has entered a body lumen, such as peritoneal cavity. An apparatus includes a handle connected to a hollow needle and a hollow stylet that extends through the hollow needle and has a blunt distal end that includes an opening for passing fluid. A spring biases the stylet to extend past the sharp distal end of the needle absent resistance by tissue against the stylet. An at least partially translucent pressure chamber configured to hold a quantity of fluid under pressure is connected to the proximal end of the stylet. The pressure chamber and stylet form a conduit for passing fluid through the opening in the blunt distal end when the stylet extends past the sharp distal end of the hollow needle.

Abstract: According to the invention, a device for controlling a penetration depth to which an injection needle penetrates a body of a human or an animal comprises a cylindrical first sleeve, an injection needle that protrudes a distal end of the first sleeve in a distal direction and a cylindrical second sleeve that receives the first sleeve. The penetration depth of the injection needle corresponds to an axial translation of the first sleeve with respect to the second sleeve. The axial translation is adjustable by a screw coupling.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: A device for establishing the penetration depth of a tubular or rod-shaped sliding part in a receiving part and to a medical handpiece using such devices. There is an adjusting element that surrounds the sliding part and which can be adjusted in the longitudinal direction of the sliding part and can be blocked in the particular position by a clamping device to establish the penetration depth of the sliding part in the receiving part. The clamping device is formed by a rocker element that is arranged between the adjusting element and the sliding part. The rocker element can be moved between a first rotational position, which allows the adjusting element to be slid in the longitudinal direction of the sliding part, and a second rotational position, which blocks the adjusting element from being slid, by rotating the adjusting element transversely to the longitudinal direction of the sliding part.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

Abstract: In various embodiments, a needle is employed in refilling drug-delivery devices.

Abstract: A pen type device for ultrasound guided fine needle aspiration cytology and biopsy comprises a hollow body having a needle hole, a sliding part slidably mounted inside the body, elastic members mounted inside the body, a syringe having a cylinder mounted, a rotating part disposed inside the sliding part and the body, a head screw-coupled to the rear end of the sliding part and drawn out from the body, and a negative pressure generating part mounted on the body to generate negative pressure to the syringe by pulling a piston of the syringe when a button located on the outer face of the body is pushed.

Abstract: The invention refers to an auto-injector for administering a dose of a liquid medicament (M), the auto-injector having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising: an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), wherein the syringe (3) is slidably arranged with respect to the housing, a drive means capable of, upon activation: pushing the needle from a retracted position into an advanced position through the orifice and past the proximal end (P), and operating the syringe to supply the dose of medicament (M), a plunger for transmitting power from the drive means to the syringe and/or stopper, activating means arranged to lock the drive means in a compressed state prior to manual operation and capable of, upon manual operation, releasing the drive means for injection, characterized in that translation of the needle and the syringe and/

Abstract: Disclosed is an apertured hydrogel that is used in connection with an insertion device to provide comfort at the site of entry into the skin. In one embodiment, the hydrogel contains antimicrobial properties to help inhibit microbial growth at the site of insertion of the device into the skin. In the invention the apertured hydrogel is provided with a medical dressing and comprises a hydrogel having an upper surface and a lower surface, a film covering the upper surface of the hydrogel, a base sheet releasably covering to the lower surface of the hydrogel, an aperture in the film and hydrogel from the upper surface to the lower surface of the hydrogel, wherein the base sheet extends beyond the hydrogel to form a tab.

Abstract: An apparatus for accessing the lumen of a vessel. The apparatus includes a handheld device and a cartridge. The handheld device includes an imaging device attachment utilized to secure an image capturing instrument, an arm coupled to the imaging device attachment. The cartridge includes a sheath, needle or guidewire coupled to the cartridge. The sheath or needle extends to the insertion depth when fully advanced, thereby allowing the sheath, needle, or guidewire to access the lumen of a vessel.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to delver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.

Abstract: The present invention relates to a compression device for stimulating the efflux of a body fluid from a body part. The device has a compression unit with a pressure-application region made of a deformable material, the region being formed to generate a repulsive force between the body part and the compression unit. The repulsive force passes through a force maximum then decreases to serve as an indication that the body part is guided sufficiently firmly and far enough onto the compression unit.

Abstract: Systems and methods which determine the position of an instrument internal to an object using an opto-mechanical sensor are shown. Embodiments utilize an opto-mechanical sensor system in which a mechanical instrument interface provides instrument movement information to a corresponding optical sensor system to determine instrument movement. Determinations of instrument movement preferably provide information regarding movement direction and speed. Such information, when used in combination with other information such as starting position or starting position offset, insertion angle or angle of attack, and/or insertion plane, is utilized by embodiments of the invention to determine the position of an instrument or portion thereof. Embodiments are adapted to accommodate different instrument configurations. Position information may be utilized in combination with an ultrasound image to display a visual representation of the instrument, or portion thereof, within a object being imaged.

Abstract: A needle insertion assistance device is provided to easily hold a needle device, which comprises a syringe and a needle having a needle wing and being attached to the syringe, in order to more reliably control the advancement of the needle during insertion of the needle into a targeted part of a human body for many medical purposes. One embodiment of the needle insertion assistance device may comprise a supporting plate, a base connected hingedly to a rear surface of the supporting plate, and a syringe holder securely affixed to a top surface of the base to slidably hold the syringe on the base and prevent the syringe from moving from side to side. This embodiment of the needle insertion assistance device may further include a needle blocker, a handle, and an angle adjusting assembly.

Abstract: A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.

Abstract: Surgical access systems and obturators for or used in surgical access systems are provided. The obturator is configured to operate or accommodate the use of at least two different sized trocars. The outer diameter of the adaptable obturator when inserted into a trocar compresses from an initial condition to a compressed condition to match the inner diameter of the trocar.

Abstract: A device for successively injecting material at predetermined distances between successive injections to body tissue along a desired path of skin surface includes an injector sub-assembly having a needle configured for injecting the material into body tissue, and a displacement sub-assembly configured to facilitate precise displacement of the needle or of the device along the path between successive injections.

Abstract: Needle assembly having the following modes of operation; a first mode wherein the safety shield can move to a first retracted position allowing injection of the piercing portion of needle from a position at least partially covering the piercing portion of the needle and a second mode wherein the safety shield moves to a position protecting the piercing portion of the needle after the first mode and is prevented from moving back to a position exposing the piercing portion of the needle.

Abstract: An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

Abstract: The invention relates to an injection device (2) comprising a carrier housing (4), in which an injection unit (8) having at least one injection liquid container (10) that can be pressed out can be inserted, and an actuating device (12), which can be driven along an injection direction (R) to activate the injection unit (8), wherein said actuating device comprises a piercing carriage (14), a receptacle (18) for the injection unit (8) and an injection carriage (16), which can be displaced relative to the piercing carriage (14), said injection carriage having an actuating plunger (48) for acting on a plunger (50) of the injection unit (8), wherein the piercing carriage (14) and the injection carriage (16) can be actuated by a force application means at least in order to carry out a piercing stroke and an injection stroke, and a piercing depth (tE) of the injection unit (8) can be set. For this purpose, the receptacle (18) is mounted on the piercing carriage (14) adjustably in the injection direction (R).

Abstract: Medicine injection apparatuses having multiple chambers. The chambers may be in lateral relationship. A torsional part is adapted to turn and be repositioned angularly relative to a main body to allow different chambers to be used to receive an injection assembly. The medicine injector can be constructed to administer multiple doses. The apparatuses may also have a storage chamber for storing the injection assembly after use. Plural drivers may be used to administer multiple doses, such as at the different angular positions of the torsional part. The apparatuses may allow multiple automatic injections from different angular positions and storage of an injector after use. Needle fright is reduced by minimizing exposure of an injection needle prior to injection.

Abstract: A kit for injecting a biomaterial into an intradiscal space accessed through an opening in the disc annulus comprises a plurality of needles, each sized for introduction through the annulus opening with a passageway for injecting the biomaterial therethrough, and each including a distal end to be disposed within the intradiscal space when the needle extends through the annulus opening. Each needle includes a stop affixed thereto at different pre-determined distances from the distal end to define the location of the distal end within the intradiscal space when the needle extends through the opening in the annulus. The kit further includes a plurality of seals defining a bore for sliding engagement with a needle, each of the plurality of seals including a sealing face for engaging the annulus around the needle. Each sealing face defines a differently configured area of contact, such as circular, elliptical, tapered and threaded.

Abstract: The present disclosure is directed to an injector device for delivering an ophthalmic solution to a cornea of an eye. The device may include a base configured to contact part of the eye, and a needle connected to the base, wherein needle may deliver the ophthalmic solution to the cornea.

Abstract: The invention relates to a gearbox for converting a first translation into a second translation, the gearbox comprising a drive collar connectable to a translative drive means and prevented from rotating with respect to a ground of the drive means, a drive sleeve rotatably arranged at least partially inside the drive collar, engaged to the drive collar by a first screw thread and prevented from translating, wherein a plunger is arranged at least partially inside the drive sleeve, engaged to the drive sleeve by a second screw thread and prevented from rotating.

Abstract: An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.

Abstract: A peripherally inserted central venous catheter having a position indicator is used in a method of detecting movement of a catheter tip within a patient's superior vena cava. The PICC comprises a catheter having a proximal end with distance marks at measured intervals, an anchor wing system secured to the catheter's proximal end, at least one extension leg secured to the anchor wing system and the position indicator attached to the extension leg. The position indicator has an area for marking a distance signifying an initial external length of catheter which extends from the point the catheter enters the patient to the point it is attached to the anchor wing and/or marking an initial full length or the internal length of catheter which is fully within the patient. Any movement of the catheter's tip is detected by comparing the current external distance mark with the initial external distance mark.

Abstract: Apparatus are disclosed for intraosseous fluid infusion or aspiration of bone marrow of a subject. Particular apparatus include a bone portal (bone-penetrating member) comprising axially-aligned distal and proximal sections. The proximal section extends in a distal direction from a proximate end of the bone portal and the distal section extends in the distal direction from the proximate section to a distal end of the bone portal. The bone portal also comprises a fluid-transport bore extending between a proximal opening in the proximal section and a distal opening in the distal section. At least a portion of the distal section has a cross-sectional area, perimeter, diameter and/or dimension greater than that of the proximal section.

Abstract: Objects are to ensure a required depressing force and puncture speed when a needle tube is punctured in the skin, and to be able to reliably situate a needle tip of a needle tube in the upper layer of skin. A needle injection assembly 2 includes a needle tube 5 having a needle tip 8 that can be punctured in a living body, a hub 6 that holds the needle tube 5, an adjustment section 12, a stabilizing section 13, and a puncture speed securing member 7. The adjustment section 12 is provided around the periphery of the needle tube 5 and has a needle projection surface 12a, from which the needle tip 8 of the needle tube 5 projects. The stabilizing section 13 extends from the hub 6, is disposed to surround the needle tube 5 and has an end face 13a that comes in contact with the skin when the needle tube 5 is punctured in the living body.

Abstract: A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post, that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.

Abstract: Apparatus and methods are provided to access bone marrow at various target areas. Such apparatus may include an intraosseous device operable to penetrate bone at a selected target area and a depth limiter operable to control depth of penetration of the intraosseous device into bone and associated bone marrow. A manual driver and a guide may be included to optimize optimum insertion of the intraosseous device at a selected insertion site on a sternum.

Abstract: A vascular access device may comprise a thin polymer patch configured to be attached to a wall of a vein. The vascular access device may also include a main body including a first end and a second end. The main body may have an inner surface defining a cavity extending between openings at the first and second ends along an axis. The first end of the main body may be connected to the polymer patch, and the cavity may taper between the second end and the first end. The vascular access device may include a cap connected to the second end of the main body. The vascular access device may also include a fluid sealed within the cavity. When the vascular access device is implanted in a patient and a dialysis needle is received in the cavity, the needle may be guided by the inner surface toward the wall of the vein.