Material Impelled Into Body By Contraction Of Expanded Elastic Material Reservoir Patents (Class 604/132)
  • Patent number: 11357909
    Abstract: A therapeutic substance delivery device includes a fluid path having a reservoir needle, a body needle, a body needle injection mechanism, and a pumping assembly (a) configured to pump the substance from the reservoir to the subject, (b) shaped to define a pump chamber, and (c) including a plunger disposed within the pump chamber. The plunger moves back and forth through a plurality of discrete motion phases. A first motion phase of the plunger actuates a first operation from a group of operations including (a) driving the reservoir needle to penetrate the reservoir, (b) advancing the body needle into the body of the subject, (c) withdrawing the substance from the reservoir, (d) pumping the substance into the subject, and (e) retracting the body needle. A second motion phase of the plunger actuates a second operation from the group of operations. Other applications are also described.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: June 14, 2022
    Assignee: EITAN MEDICAL LTD.
    Inventors: Ori Ben-David, Andrei Yosef, Shai Peretz, Felix Kolderar
  • Patent number: 11324936
    Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 10, 2022
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Michael A. Vogelbaum
  • Patent number: 11273254
    Abstract: A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: March 15, 2022
    Assignee: Avent, Inc.
    Inventors: Hector Dung Truong, Justin J. Coker, Paul D. Jun
  • Patent number: 11253644
    Abstract: Bladders and elastomeric pumps for infusion assemblies are provided. For example, a bladder may comprise a body extending over a length from a first end to an opposing second end; an outer diameter; an inner diameter; and a wall thickness. The wall thickness may gradually transition from a first wall thickness at the first end to a second wall thickness at the second end. In other embodiments, the wall thickness at a midpoint of the length is different than the wall thickness at each of the first end and the second end. An elastomeric pump may comprise an inflatable elastomeric bladder and a mandrel. The bladder includes a body extending over a bladder length from a first bladder end to an opposing second bladder end and a wall thickness, which is different at a midpoint of the bladder length than at each of the first and second bladder ends.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: February 22, 2022
    Assignee: Avent, Inc.
    Inventors: Gary D. Aurin, Travis W. Klyber, Thad R. Hmielak
  • Patent number: 11172708
    Abstract: A cartridge (30) for use with an aerosol generating system (10) includes a reservoir (32) for storing an aerosol-forming liquid (34) and an induction heatable element (36). The cartridge (30) employs a capillary element (38) to convey the aerosol-forming liquid (34) from the reservoir (32) to the induction heatable element (36) and the induction heatable element (36) is arranged to heat the conveyed aerosol-forming liquid to vaporise it.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: November 16, 2021
    Inventors: Mark Gill, Lubos Brvenik
  • Patent number: 11154698
    Abstract: A medical system. The medical system includes at least one compartment for a fluid, a fluid path and at least one microneedle fluidly connected to the at least one compartment by the fluid path. A medical infusion system is also disclosed. The system includes a wearable housing, at least one non-pressurized compartment for a fluid contained within the housing, at least one fluid path fluidly connected to the at least one compartment and at least one microneedle fluidly connected to the at least one compartment by the fluid path wherein the fluid path extends through the microneedle.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: October 26, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray
  • Patent number: 11033458
    Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: June 15, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke Shirotani, Kazuki Kuriyama, Seiji Tokumoto
  • Patent number: 10973366
    Abstract: A handheld cylinder (103) capable of containing hot water. The cylinder has a pump 105 for pressurised the headspace above the hot water with air. The cylinder (103) also has a spout (107) which can be open and closed by a valve (500). When the pressurised air which has been warmed by the hot water is released from the spout (107), the air can be directed into a body of milk to swirl the milk in its container (109) to cause frothing and foaming of the milk.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: April 13, 2021
    Assignee: THUNDER HOST LIMITED
    Inventors: Kam Ming Lui, Wing Kin Martin Hui
  • Patent number: 10967123
    Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 6, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Lionel Vedrine, Ralph Sonderegger, Curt Bingham
  • Patent number: 10945464
    Abstract: There is provided an electronic smoking device (10; 110; 210; 310) comprising a power supply (18), a liquid reservoir (34; 34; 234; 334) storing a liquid, and an atomizer (26). The atomizer (26) is adapted to atomize the liquid stored in the liquid reservoir (34; 34; 234; 334) when operated by the power supply (18). The liquid reservoir (34; 34; 234; 334) comprises a first chamber (40) storing the liquid, which first chamber (40) has a variable volume that is reducible and non-increasable.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 16, 2021
    Assignee: Fontem Holdings 1 B.V.
    Inventors: Neha Daryani, Lutz Deichmann
  • Patent number: 10905596
    Abstract: A method for manufacturing absorbent articles comprises delivering a continuous web assembly including a backsheet material, a liquid permeable bodyside liner material, and an absorbent structure interposed between the backsheet material and the bodyside liner material, the web assembly having a body-facing side and a garment-facing side; attaching a discrete segment of first waist elastic material to the body-facing side of the web assembly; attaching a discrete segment of second waist elastic material to the garment-facing side of the web assembly such that the web assembly is interposed between the discrete segments of first and second waist elastic materials; and cutting the web assembly to form a plurality of absorbent articles.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: February 2, 2021
    Assignee: KIMBERLY-CLARK WORLDWIDE, INC.
    Inventors: Joseph J. Sina, Kathleen Irene Bennett, Marcille Faye Ruman, Thomas Harold Roessler
  • Patent number: 10869505
    Abstract: The present invention concerns an electronic smoking device that includes a battery portion (12) comprising a battery (18), an atomizer/liquid reservoir portion (14) comprising a multicameral liquid reservoir (34), and an atomizer (26) operable when connected to the battery (18) to atomize liquid stored in the multicameral liquid reservoir (34). The multicameral liquid reservoir (34) comprises a first chamber (202) comprising an unflavored fluid, a second chamber (204) comprising a flavored fluid, the first chamber (202) and the second chamber (204) being disposed in communication with each other via an opening (206), and a plurality of reservoir walls (208) enclosing the two chambers. A portion of the plurality of reservoir walls (208) enclosing the second chamber (204) comprising a flexible portion (40), the flexible portion (40) when acted upon causing the flavored fluid to migrate from the second chamber (204) to the first chamber (202) through the opening (206).
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: December 22, 2020
    Assignee: Fontem Holdings 1 B.V.
    Inventors: Vaclav Borkovec, Lutz Deichmann
  • Patent number: 10871788
    Abstract: In some embodiments, a tube portion can be configured to be fluidically coupled to a patient access component. A source of pressurized fluid can be coupled to the tube portion and can be configured to deliver fluid to the tube portion at a source pressure. A fluid pressure regulating device can include an expandable reservoir and can be coupled to the tube portion such that the expandable reservoir is in fluidic communication with the tube portion. The fluid pressure regulating device can be configured such that, when fluid is delivered from the source of pressurized fluid to the lumen of the tube portion at the source pressure, the expandable reservoir of the fluid pressure regulating device can receive fluid such that the expandable reservoir of the fluid pressure regulating device expands and fluid is delivered from the lumen of the tube portion to the patient via the patient access component.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: December 22, 2020
    Assignee: 410 Medical, Inc.
    Inventors: Andrew Lane, Savannah Carlsen, Galen C. Robertson, Mark D. Piehl
  • Patent number: 10792433
    Abstract: The present invention concerns a syringe assembly comprising a hollow tubular syringe body, having a proximal end and a distal end, a plunger rod, axially movable in the syringe body between an initial position and a final position. The assembly also includes a support transversally stiff for supporting the plunger rod, the support having a distal end and a proximal end respectively transversally fixed to the syringe body and to the plunger rod, the proximal end of the support being movable with respect to the syringe body.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 6, 2020
    Assignee: IPSEN PHARMA
    Inventors: Steven Mark Guy Rolfe, Andrew Lewis
  • Patent number: 10729846
    Abstract: A needle assembly to prevent fluid/vapor escape so as to reduce or prevent fluid exposure to a clinician during use of the needle assembly. The needle assembly may include a handle portion with a needle extending therefrom, and a base portion releasably coupled to the handle portion. The base portion may include a safety assembly to shield a distal tip of the needle and prevent user contact therewith. The base portion may further include a self-sealing pad covering a bottom external surface thereof. The self-sealing pad may include an upper surface designed to mate with the base portion and a raised portion compressively positioned in the opening of the bottom external surface. The needle assembly may further include a fluid isolation component.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 4, 2020
    Assignee: C. R. Bard, Inc.
    Inventors: Jeremy A. Pearce, Bradley J. VanderStek, Jason R. Stats, William R. Barron
  • Patent number: 10583241
    Abstract: A drug delivery device for injecting medicament, the device including a main body having a surface for contacting a patient, an actuation button (110, 420, 436) movably disposed relative to the main body, and a reservoir disposed within the main body for containing a medicament. The device also includes a needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, wherein the lumen is fluidly connectable with the reservoir. The device further includes a removable needle cover (114, 400) for selectively covering the distal end of the needle and selectively preventing movement of the actuation button relative to the main body that initiates activation of the device.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 10, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Haiming Wu, Danial P. Ferreira
  • Patent number: 10493256
    Abstract: A port (1) for a catheter comprises: a housing (10) having a base plate (12); a cavity (140) arranged in the housing (10) for receiving a fluid; a membrane (13) attached to the housing (10) and arranged on an opening (102) of the housing (10) for sealing the opening (102) such that the cavity (140) is enclosed in the housing (10) in a fluid-tight manner; and a connector (15) for connecting a catheter (2) to the housing (10) to provide a fluid connection between the cavity (140) and the catheter (2). The port (1) has an outer shape defined by the housing (10) and the membrane (13) attached to the housing (10). In addition at least one adapter piece (3, 4) is provided, the at least one adapter piece (3, 4) in a preassembly state being separate from the housing (10) and being attachable to the housing (10) to alter the outer shape of the port (1), wherein the port (1) is operational with or without the at least one adapter piece (3, 4) attached to the housing (10).
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 3, 2019
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventor: Christoph Jochum
  • Patent number: 10406271
    Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 10, 2019
    Assignee: Leukocare AG
    Inventors: Stefan Margraf, Martin Scholz
  • Patent number: 10384005
    Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontroller(s) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: August 20, 2019
    Assignee: NEW WORLD PHARMACEUTICALS, LLC
    Inventors: Frederick A. Sexton, Ian Ivar Suni, Cetin Cetinkaya, Stephanie Schuckers, Eduard Sazonov
  • Patent number: 10376640
    Abstract: A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: August 13, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Emilian Istoc, Himanshu Patel
  • Patent number: 10369274
    Abstract: A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: August 6, 2019
    Assignee: UNL Holdings LLC
    Inventors: Sean M. O'Connor, Ian B. Hanson, Paul F. Bente, IV, Rajan Ramaswamy, Daniel S. Codd, Scott W. Beaver, Kevin L. Bokelman, John C. Love
  • Patent number: 10369289
    Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: August 6, 2019
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Paul H. Norton, Ran Hezkiahu
  • Patent number: 10363367
    Abstract: The present invention relates to a filling device for filling a reservoir, the filling device comprising a housing configured to hold a container for a liquid; a conduit arranged for fluid engagement with the container; a drive unit configured to expel a liquid from the container through the conduit; and a connector configured to be attachable to a reservoir, wherein the connector comprises at least one contact element; the filling device further comprising a trigger assembly arranged to act on the drive unit such that when the trigger assembly is activated the liquid is expelled from the container through the conduit.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: July 30, 2019
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Stephan Mueller-Pathle
  • Patent number: 10279118
    Abstract: A drive mechanism (11) for a delivery device comprising a drive member (17) for driving a piston rod (13); a moveable dose setting member (19, 35) being disengaged from the drive member (17) in a dose setting state and being moveable in a drive direction in a dose delivery state, wherein the dose setting member (19, 35) engages with the drive member (17) in the dose delivery state in such a manner that the movement of the dose setting member (19, 35) in the drive direction is transferred to the drive member (17); and a spring member (21) being coupled to the dose setting member (19, 35) in such a manner that the movement of the dose setting member (19, 35) in a setting direction loads the spring member (21) in the dose setting state, the spring force of the loaded spring member (21) driving the dose setting member (19, 35) in the drive direction in the dose delivery state.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: May 7, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Matt Schumann, Mark Pawulski
  • Patent number: 10239682
    Abstract: A device for dispensing a material under pressure, including at least one elastic portion defining at least one wall of a chamber defining a volume within which the material is to be contained; and at least one non-elastic portion coupled to the at least one elastic portion and affecting a geometry of one or both of the elastic portion and of the chamber; wherein, at least when the material is contained within the chamber, the at least one elastic portion is stretched so as to urge a reduction in volume of the chamber by at least 70%. The non-elastic portion is optionally rigid.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: March 26, 2019
    Assignee: GreenSpense Ltd.
    Inventors: Gadi Har-Shai, Adam Schwartz
  • Patent number: 10238795
    Abstract: Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: March 26, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Gavriel J. Iddan, Illai Gescheit
  • Patent number: 10188797
    Abstract: This pharmaceutical injection device may be provided with a main body case, a pharmaceutical syringe mounting portion, a piston, a piston feed screw or the like, and a cover. At a first end, the main body case may have an injection needle mounting portion to which an injection needle is mounted. The pharmaceutical syringe mounting portion may be provided inside the main body case, and a pharmaceutical syringe may be mounted thereto. The piston may be provided movably with respect to the pharmaceutical syringe that is mounted to the pharmaceutical syringe mounting portion. The piston feed screw or the like drives the piston. The cover may be provided on the first end side of the main body case and operates to open and close the injection needle mounting portion.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: January 29, 2019
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Kenji Murakami, Mitsuteru Fujimoto
  • Patent number: 9968736
    Abstract: A liquid injector that additionally supplies charged liquid to a patient is provided. The liquid injector continuously supplies a fixed quantity of liquid to a patient only when the fixed quantity of liquid has been charged.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 15, 2018
    Assignee: Ace Medical Co., Ltd.
    Inventor: Jong-Woo Lee
  • Patent number: 9744294
    Abstract: A puncture device includes a puncture needle including an outer needle and an inner tube located in the outer needle; a housing unit accommodating the puncture needle; and a puncture mechanism within the housing unit. The puncture mechanism includes a push-in unit configured to be pushed in with respect to the housing unit, an outer needle slide unit attached to the outer needle, a stopper, an elastic member, a first end of which is fixed to the housing unit and a second end of which is fixed to the outer needle slide unit, and a fixation release unit configured to release the fixation between the push-in unit and the outer needle slide unit and the fixation between the outer needle slide unit and the inner tube.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: August 29, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Joji Uchiyama, Hiromasa Kohno
  • Patent number: 9693781
    Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device includes an occluder portion and an anchor portion, the anchor portion hingably coupled to the occluder portion. With this arrangement, the anchor portion actuates and pivots relative to the occluder portion between an anchor deployed position and an anchor non-deployed position while the occluder portion is in an occluder deployed position.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: July 4, 2017
    Assignee: Coherex Medical, Inc.
    Inventors: Scott D. Miles, Clark C. Davis, Daryl R. Edmiston, Richard J. Linder, John Alexander Martin
  • Patent number: 9669163
    Abstract: A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that functions to controllably move the shuttle forwardly of the housing.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: June 6, 2017
    Assignee: BioQ Pharma Incorporated
    Inventors: Ralph I. McNall, III, Thomas T. Donze, Donald B. Bivin
  • Patent number: 9649438
    Abstract: A system and method for physiological monitoring and regulation of a drug infusion device. The system includes an internal compact unit that is implantable in a patient having a pulmonary disorder, the internal unit encasing a power supply, a fluid reservoir, a motor pump, a digital control unit, and a radio frequency transmitter. An infusion catheter is connected to the fluid reservoir and motor pump for automatically infusing a drug into a right ventricle of the patient during a diastole phase of a cardiac cycle. The system includes an external unit for monitoring and storing a plurality of physiological parameters of the patient and for making adjustments to a drug infusion rate.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 16, 2017
    Assignee: Medical Software, LLC
    Inventor: Demir Baykal
  • Patent number: 9649433
    Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 16, 2017
    Assignee: DEKA Products Limited Partnership
    Inventors: Gregory R. Lanier, Jr., Larry B. Gray, Richard J. Lanigan, Dean Kamen, Stephen L. Fichera, John M. Kerwin
  • Patent number: 9456955
    Abstract: A filling aid. The filling aid includes a needle housing portion including at least one tab having a starting position and a filling position, and a filling needle cradle including a filling needle, the filling needle cradle slidable connected to the needle housing portion and having a starting position and a filling position, wherein when the at least one tab on the needle housing moves from a starting position to a filling position, the filling needle cradle slides from a starting position to a filling position, and wherein when the at least one tab on the needle housing moves from a filling position to a starting position, the filling needle cradle slides from a filling position to a starting position.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: October 4, 2016
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Gregory R. Lanier, Jr., Dean Kamen, Bright C. K. Foo, Kevin L. Grant, Lisa A. Panneton
  • Patent number: 9375529
    Abstract: Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: June 28, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: Gary Searle, Keith N Knapp, Roman Tunkel, Peter Skutnik, Lionel Vedrine
  • Patent number: 9352026
    Abstract: The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: May 31, 2016
    Assignee: Midatech Limited
    Inventors: Thomas Rademacher, Phillip Williams
  • Patent number: 9295776
    Abstract: A casing may be configured to envelop at least a portion of a plunger arm attached to a plunger head located in a reservoir. A plunger head moveable in a reservoir may have a front portion comprising a first material compatible with fluidic media in an interior volume of the reservoir. A seal member having a first end and a second end that taper to a mid-portion may be positioned between a reservoir and a plunger head. A bias member may be configured to force a plunger arm operatively connected to a plunger head against a drive member to operatively engage the plunger arm to the drive member. A plunger head moveable in a reservoir may have a first ridge, a second ridge, a seal member adjacent at least one of the ridges, and protrusions arranged around at least one of the ridges.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: March 29, 2016
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Colin A. Chong, Eric M. Lorenzen, Rafael Bikovsky, Arsen Ibranyan
  • Patent number: 9278176
    Abstract: A system, for use in determining a volume in a reservoir, includes a bulkhead, a plunger assembly, and a base. The plunger assembly is connected to the bulkhead. The plunger assembly includes a first plunger and a second plunger. The first plunger has a corresponding first biasing member. The second plunger has a corresponding second biasing member. The base of the reservoir is connected to the first plunger. Movement of the base causes compression or expansion of the first biasing member, which causes compression or expansion of the second biasing member. The bulkhead, the first plunger, and the base define a first portion of the reservoir. Positions of the first plunger and the base, relative to the bulkhead, are based on the volume in the reservoir.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 8, 2016
    Assignee: Medtronic, Inc.
    Inventor: Keith A. Miesel
  • Patent number: 9205190
    Abstract: A modular infusion pump for administering a product, including a pump housing, a reservoir to contain the product, a delivery device associated with the pump housing to deliver the product from the reservoir, an energy source for the delivery device, another housing separate from the pump housing for receiving the energy source, and a transmission for transmitting energy from the energy source to the delivery device.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: December 8, 2015
    Assignee: Roche Diagnostics International AG
    Inventors: Axel Remde, Gilbert Schiltges
  • Patent number: 8998850
    Abstract: Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: April 7, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray, Russell H. Beavis
  • Patent number: 8986253
    Abstract: Two chamber pumps and related methods provide a platform for measuring flow rate in about real time without contacting the material being pumped. Pressure and optional temperature sensors disposed in a pressurized chamber allow for flow material delivery calculations after being calibrated or by knowing the initial volume of the flow material to be delivered.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: March 24, 2015
    Assignee: Tandem Diabetes Care, Inc.
    Inventor: Paul M. DiPerna
  • Patent number: 8986250
    Abstract: A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: March 24, 2015
    Assignees: Wisconsin Alumni Research Foundation, Ration, Inc.
    Inventors: David J. Beebe, Benjamin J. Moga, Tony Escarcega, Kent Chase
  • Patent number: 8968242
    Abstract: An improved elastomeric pump for an infusion assembly. The pump includes a generally cylindrical mandrel body with first end, an opposed second end, a length, an outer diameter corresponding to a first radius (Rmandrel), a central bore extending through the length, a first port extending from the outer diameter to the bore to provide a fluid passageway, a fill port and an exit port in fluid communication with the bore. The pump includes an inflatable elastomeric tube disposed concentrically about the mandrel, the tube being sealingly secured on the mandrel near the respective ends of the tube and having an original inner diameter that corresponds to a second radius (r) so that it approximately matches the outer diameter of the mandrel (Rmandrel), a length (L) less than the length of the mandrel, a wall thickness (t) such that: (0.4225×r)<t?(0.660×r).
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: March 3, 2015
    Assignee: Avent, Inc.
    Inventors: Kokeb Tefera, Quang Ngoc Vu, Deepak Gandhi
  • Patent number: 8945052
    Abstract: A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: February 3, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: Srinivas Chiravuri, Allan Evans, Yogesh B. Gianchandani, Jong Moon Park
  • Patent number: 8945064
    Abstract: An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: February 3, 2015
    Assignee: CeQur SA
    Inventors: Peter Gravesen, Per Brandt Rasmussen, Holger Dirac
  • Patent number: 8932253
    Abstract: A method and apparatus for infusing medication into a patient's body using a medication chamber referenced to ambient pressure. The apparatus includes a medication chamber enclosed by a peripheral wall which includes a movable portion configured to transfer exterior ambient pressure into the chamber. Means are provided for exerting a negative bias force acting on the movable portion in a direction opposed to the ambient pressure force. Thus, the resultant pressure in the chamber will be negative with respect to ambient pressure, reducing the risk that the chamber can be overpressurized and produce an unintended medication discharge.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: January 13, 2015
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Scott R. Gibson, Peter C. Lord
  • Publication number: 20140378891
    Abstract: An infusion system comprises an infusion set (30) with one or more advanced features including tube set strain relief (10), infusion pumps having heat exchange abilities and two-direction pumping abilities (100), Piezo pump devices (200), reservoirs (220, 240) made from expanded tubing, and oil impregnated pump plungers (302). An exemplary strain relief (10) includes an adhesive layer (12) such as pressure sensitive adhesive (PSA) secured to a base (14). The base (14) rotatably receives a pin (18) of a tube holder (16). The pin (18) is captured within an opening (22) of the base (14) to allow 360 degree rotation of the tube holder (16).
    Type: Application
    Filed: February 8, 2012
    Publication date: December 25, 2014
    Inventors: Gary M. Searle et al., Charles G. Hwang
  • Patent number: 8915904
    Abstract: A spiral-coil antenna conforming to a non-planar contour is deployed, in various embodiments, in an implantable device for controllably ejecting fluid into an anatomic region. The antenna facilitates wireless communications with the implantable device and external charging thereof. In one implementation, the device has a non-planar contour and the spiral coil defines a non-planar surface conforming to the non-planar contour.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: December 23, 2014
    Assignee: MiniPumps, LLC
    Inventors: Jeffrey Brennan, Sean Caffey, Michelle Journey, Fukang Jiang
  • Patent number: 8882481
    Abstract: A compact medical pump includes a linear peristaltic pumping mechanism driven by a motor located within a periphery of a belt of the pumping mechanism. The motor drives a gear set that drives a driving pulley which engages the belt having the rollers. A battery for the pump is positioned adjacent to the gear set. The pump includes a controller and user interface for operating the pumping mechanism as a function of pumping parameters input via the user interface. The controller may sense motor current and determine fluid path characteristics based on the sensed current.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: November 11, 2014
    Assignee: Covidien LP
    Inventor: James Harr
  • Patent number: 8876802
    Abstract: Devices of this invention include replaceable cartridges for delivery of doses of fluids. Cartridges having a fluid supply reservoir comprising an expandable element are designed to be connected with non-disposable actuating module supplied with a sensor, a mechanism to apply a force to the fluid, thereby forcing a predetermined dose out of the reservoir, and a processor providing control outputs from a sensor system according to preprogrammed instructions. Methods of this invention include delivery of microdoses of fluids using devices of this invention.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: November 4, 2014
    Inventor: Leonid Grigorov