Material Impelled Into Body By Contraction Of Expanded Elastic Material Reservoir Patents (Class 604/132)
  • Patent number: 10406271
    Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 10, 2019
    Assignee: Leukocare AG
    Inventors: Stefan Margraf, Martin Scholz
  • Patent number: 10384005
    Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontroller(s) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: August 20, 2019
    Assignee: NEW WORLD PHARMACEUTICALS, LLC
    Inventors: Frederick A. Sexton, Ian Ivar Suni, Cetin Cetinkaya, Stephanie Schuckers, Eduard Sazonov
  • Patent number: 10376640
    Abstract: A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: August 13, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Emilian Istoc, Himanshu Patel
  • Patent number: 10369289
    Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: August 6, 2019
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Paul H. Norton, Ran Hezkiahu
  • Patent number: 10369274
    Abstract: A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: August 6, 2019
    Assignee: UNL Holdings LLC
    Inventors: Sean M. O'Connor, Ian B. Hanson, Paul F. Bente, IV, Rajan Ramaswamy, Daniel S. Codd, Scott W. Beaver, Kevin L. Bokelman, John C. Love
  • Patent number: 10363367
    Abstract: The present invention relates to a filling device for filling a reservoir, the filling device comprising a housing configured to hold a container for a liquid; a conduit arranged for fluid engagement with the container; a drive unit configured to expel a liquid from the container through the conduit; and a connector configured to be attachable to a reservoir, wherein the connector comprises at least one contact element; the filling device further comprising a trigger assembly arranged to act on the drive unit such that when the trigger assembly is activated the liquid is expelled from the container through the conduit.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: July 30, 2019
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Stephan Mueller-Pathle
  • Patent number: 10279118
    Abstract: A drive mechanism (11) for a delivery device comprising a drive member (17) for driving a piston rod (13); a moveable dose setting member (19, 35) being disengaged from the drive member (17) in a dose setting state and being moveable in a drive direction in a dose delivery state, wherein the dose setting member (19, 35) engages with the drive member (17) in the dose delivery state in such a manner that the movement of the dose setting member (19, 35) in the drive direction is transferred to the drive member (17); and a spring member (21) being coupled to the dose setting member (19, 35) in such a manner that the movement of the dose setting member (19, 35) in a setting direction loads the spring member (21) in the dose setting state, the spring force of the loaded spring member (21) driving the dose setting member (19, 35) in the drive direction in the dose delivery state.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: May 7, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Matt Schumann, Mark Pawulski
  • Patent number: 10239682
    Abstract: A device for dispensing a material under pressure, including at least one elastic portion defining at least one wall of a chamber defining a volume within which the material is to be contained; and at least one non-elastic portion coupled to the at least one elastic portion and affecting a geometry of one or both of the elastic portion and of the chamber; wherein, at least when the material is contained within the chamber, the at least one elastic portion is stretched so as to urge a reduction in volume of the chamber by at least 70%. The non-elastic portion is optionally rigid.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: March 26, 2019
    Assignee: GreenSpense Ltd.
    Inventors: Gadi Har-Shai, Adam Schwartz
  • Patent number: 10238795
    Abstract: Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: March 26, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Gavriel J. Iddan, Illai Gescheit
  • Patent number: 10188797
    Abstract: This pharmaceutical injection device may be provided with a main body case, a pharmaceutical syringe mounting portion, a piston, a piston feed screw or the like, and a cover. At a first end, the main body case may have an injection needle mounting portion to which an injection needle is mounted. The pharmaceutical syringe mounting portion may be provided inside the main body case, and a pharmaceutical syringe may be mounted thereto. The piston may be provided movably with respect to the pharmaceutical syringe that is mounted to the pharmaceutical syringe mounting portion. The piston feed screw or the like drives the piston. The cover may be provided on the first end side of the main body case and operates to open and close the injection needle mounting portion.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: January 29, 2019
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Kenji Murakami, Mitsuteru Fujimoto
  • Patent number: 9968736
    Abstract: A liquid injector that additionally supplies charged liquid to a patient is provided. The liquid injector continuously supplies a fixed quantity of liquid to a patient only when the fixed quantity of liquid has been charged.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 15, 2018
    Assignee: Ace Medical Co., Ltd.
    Inventor: Jong-Woo Lee
  • Patent number: 9744294
    Abstract: A puncture device includes a puncture needle including an outer needle and an inner tube located in the outer needle; a housing unit accommodating the puncture needle; and a puncture mechanism within the housing unit. The puncture mechanism includes a push-in unit configured to be pushed in with respect to the housing unit, an outer needle slide unit attached to the outer needle, a stopper, an elastic member, a first end of which is fixed to the housing unit and a second end of which is fixed to the outer needle slide unit, and a fixation release unit configured to release the fixation between the push-in unit and the outer needle slide unit and the fixation between the outer needle slide unit and the inner tube.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: August 29, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Joji Uchiyama, Hiromasa Kohno
  • Patent number: 9693781
    Abstract: Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device includes an occluder portion and an anchor portion, the anchor portion hingably coupled to the occluder portion. With this arrangement, the anchor portion actuates and pivots relative to the occluder portion between an anchor deployed position and an anchor non-deployed position while the occluder portion is in an occluder deployed position.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: July 4, 2017
    Assignee: Coherex Medical, Inc.
    Inventors: Scott D. Miles, Clark C. Davis, Daryl R. Edmiston, Richard J. Linder, John Alexander Martin
  • Patent number: 9669163
    Abstract: A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that functions to controllably move the shuttle forwardly of the housing.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: June 6, 2017
    Assignee: BioQ Pharma Incorporated
    Inventors: Ralph I. McNall, III, Thomas T. Donze, Donald B. Bivin
  • Patent number: 9649438
    Abstract: A system and method for physiological monitoring and regulation of a drug infusion device. The system includes an internal compact unit that is implantable in a patient having a pulmonary disorder, the internal unit encasing a power supply, a fluid reservoir, a motor pump, a digital control unit, and a radio frequency transmitter. An infusion catheter is connected to the fluid reservoir and motor pump for automatically infusing a drug into a right ventricle of the patient during a diastole phase of a cardiac cycle. The system includes an external unit for monitoring and storing a plurality of physiological parameters of the patient and for making adjustments to a drug infusion rate.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 16, 2017
    Assignee: Medical Software, LLC
    Inventor: Demir Baykal
  • Patent number: 9649433
    Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 16, 2017
    Assignee: DEKA Products Limited Partnership
    Inventors: Gregory R. Lanier, Jr., Larry B. Gray, Richard J. Lanigan, Dean Kamen, Stephen L. Fichera, John M. Kerwin
  • Patent number: 9456955
    Abstract: A filling aid. The filling aid includes a needle housing portion including at least one tab having a starting position and a filling position, and a filling needle cradle including a filling needle, the filling needle cradle slidable connected to the needle housing portion and having a starting position and a filling position, wherein when the at least one tab on the needle housing moves from a starting position to a filling position, the filling needle cradle slides from a starting position to a filling position, and wherein when the at least one tab on the needle housing moves from a filling position to a starting position, the filling needle cradle slides from a filling position to a starting position.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: October 4, 2016
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Gregory R. Lanier, Jr., Dean Kamen, Bright C. K. Foo, Kevin L. Grant, Lisa A. Panneton
  • Patent number: 9375529
    Abstract: Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: June 28, 2016
    Assignee: Becton, Dickinson and Company
    Inventors: Gary Searle, Keith N Knapp, Roman Tunkel, Peter Skutnik, Lionel Vedrine
  • Patent number: 9352026
    Abstract: The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: May 31, 2016
    Assignee: Midatech Limited
    Inventors: Thomas Rademacher, Phillip Williams
  • Patent number: 9295776
    Abstract: A casing may be configured to envelop at least a portion of a plunger arm attached to a plunger head located in a reservoir. A plunger head moveable in a reservoir may have a front portion comprising a first material compatible with fluidic media in an interior volume of the reservoir. A seal member having a first end and a second end that taper to a mid-portion may be positioned between a reservoir and a plunger head. A bias member may be configured to force a plunger arm operatively connected to a plunger head against a drive member to operatively engage the plunger arm to the drive member. A plunger head moveable in a reservoir may have a first ridge, a second ridge, a seal member adjacent at least one of the ridges, and protrusions arranged around at least one of the ridges.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: March 29, 2016
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Colin A. Chong, Eric M. Lorenzen, Rafael Bikovsky, Arsen Ibranyan
  • Patent number: 9278176
    Abstract: A system, for use in determining a volume in a reservoir, includes a bulkhead, a plunger assembly, and a base. The plunger assembly is connected to the bulkhead. The plunger assembly includes a first plunger and a second plunger. The first plunger has a corresponding first biasing member. The second plunger has a corresponding second biasing member. The base of the reservoir is connected to the first plunger. Movement of the base causes compression or expansion of the first biasing member, which causes compression or expansion of the second biasing member. The bulkhead, the first plunger, and the base define a first portion of the reservoir. Positions of the first plunger and the base, relative to the bulkhead, are based on the volume in the reservoir.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 8, 2016
    Assignee: Medtronic, Inc.
    Inventor: Keith A. Miesel
  • Patent number: 9205190
    Abstract: A modular infusion pump for administering a product, including a pump housing, a reservoir to contain the product, a delivery device associated with the pump housing to deliver the product from the reservoir, an energy source for the delivery device, another housing separate from the pump housing for receiving the energy source, and a transmission for transmitting energy from the energy source to the delivery device.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: December 8, 2015
    Assignee: Roche Diagnostics International AG
    Inventors: Axel Remde, Gilbert Schiltges
  • Patent number: 8998850
    Abstract: Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: April 7, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray, Russell H. Beavis
  • Patent number: 8986253
    Abstract: Two chamber pumps and related methods provide a platform for measuring flow rate in about real time without contacting the material being pumped. Pressure and optional temperature sensors disposed in a pressurized chamber allow for flow material delivery calculations after being calibrated or by knowing the initial volume of the flow material to be delivered.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: March 24, 2015
    Assignee: Tandem Diabetes Care, Inc.
    Inventor: Paul M. DiPerna
  • Patent number: 8986250
    Abstract: A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a pressure source engageable with the reservoir. The pressure source is movable between a first configuration and a second configuration wherein the pressure source exerts a pressure on the reservoir to urge the drug therefrom. An output conduit is provided for transmitting the drug into the individual. An actuation mechanism is operatively connected to the pressure source and the output conduit. The actuation mechanism is movable between a non-actuated position and an actuated position wherein pressure source moves from the first configuration to the second configuration and wherein the input of the output conduit communicates with the drug and the output end of the output conduit is receivable in the individual.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: March 24, 2015
    Assignees: Wisconsin Alumni Research Foundation, Ration, Inc.
    Inventors: David J. Beebe, Benjamin J. Moga, Tony Escarcega, Kent Chase
  • Patent number: 8968242
    Abstract: An improved elastomeric pump for an infusion assembly. The pump includes a generally cylindrical mandrel body with first end, an opposed second end, a length, an outer diameter corresponding to a first radius (Rmandrel), a central bore extending through the length, a first port extending from the outer diameter to the bore to provide a fluid passageway, a fill port and an exit port in fluid communication with the bore. The pump includes an inflatable elastomeric tube disposed concentrically about the mandrel, the tube being sealingly secured on the mandrel near the respective ends of the tube and having an original inner diameter that corresponds to a second radius (r) so that it approximately matches the outer diameter of the mandrel (Rmandrel), a length (L) less than the length of the mandrel, a wall thickness (t) such that: (0.4225×r)<t?(0.660×r).
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: March 3, 2015
    Assignee: Avent, Inc.
    Inventors: Kokeb Tefera, Quang Ngoc Vu, Deepak Gandhi
  • Patent number: 8945064
    Abstract: An infusion device for continuous infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion. The device comprises a flow regulating device comprising a passage defined by at least a first element and a second element, wherein at least one of the first and second element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: February 3, 2015
    Assignee: CeQur SA
    Inventors: Peter Gravesen, Per Brandt Rasmussen, Holger Dirac
  • Patent number: 8945052
    Abstract: A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: February 3, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: Srinivas Chiravuri, Allan Evans, Yogesh B. Gianchandani, Jong Moon Park
  • Patent number: 8932253
    Abstract: A method and apparatus for infusing medication into a patient's body using a medication chamber referenced to ambient pressure. The apparatus includes a medication chamber enclosed by a peripheral wall which includes a movable portion configured to transfer exterior ambient pressure into the chamber. Means are provided for exerting a negative bias force acting on the movable portion in a direction opposed to the ambient pressure force. Thus, the resultant pressure in the chamber will be negative with respect to ambient pressure, reducing the risk that the chamber can be overpressurized and produce an unintended medication discharge.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: January 13, 2015
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Scott R. Gibson, Peter C. Lord
  • Publication number: 20140378891
    Abstract: An infusion system comprises an infusion set (30) with one or more advanced features including tube set strain relief (10), infusion pumps having heat exchange abilities and two-direction pumping abilities (100), Piezo pump devices (200), reservoirs (220, 240) made from expanded tubing, and oil impregnated pump plungers (302). An exemplary strain relief (10) includes an adhesive layer (12) such as pressure sensitive adhesive (PSA) secured to a base (14). The base (14) rotatably receives a pin (18) of a tube holder (16). The pin (18) is captured within an opening (22) of the base (14) to allow 360 degree rotation of the tube holder (16).
    Type: Application
    Filed: February 8, 2012
    Publication date: December 25, 2014
    Inventors: Gary M. Searle et al., Charles G. Hwang
  • Patent number: 8915904
    Abstract: A spiral-coil antenna conforming to a non-planar contour is deployed, in various embodiments, in an implantable device for controllably ejecting fluid into an anatomic region. The antenna facilitates wireless communications with the implantable device and external charging thereof. In one implementation, the device has a non-planar contour and the spiral coil defines a non-planar surface conforming to the non-planar contour.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: December 23, 2014
    Assignee: MiniPumps, LLC
    Inventors: Jeffrey Brennan, Sean Caffey, Michelle Journey, Fukang Jiang
  • Patent number: 8882481
    Abstract: A compact medical pump includes a linear peristaltic pumping mechanism driven by a motor located within a periphery of a belt of the pumping mechanism. The motor drives a gear set that drives a driving pulley which engages the belt having the rollers. A battery for the pump is positioned adjacent to the gear set. The pump includes a controller and user interface for operating the pumping mechanism as a function of pumping parameters input via the user interface. The controller may sense motor current and determine fluid path characteristics based on the sensed current.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: November 11, 2014
    Assignee: Covidien LP
    Inventor: James Harr
  • Patent number: 8876802
    Abstract: Devices of this invention include replaceable cartridges for delivery of doses of fluids. Cartridges having a fluid supply reservoir comprising an expandable element are designed to be connected with non-disposable actuating module supplied with a sensor, a mechanism to apply a force to the fluid, thereby forcing a predetermined dose out of the reservoir, and a processor providing control outputs from a sensor system according to preprogrammed instructions. Methods of this invention include delivery of microdoses of fluids using devices of this invention.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: November 4, 2014
    Inventor: Leonid Grigorov
  • Patent number: 8864711
    Abstract: Methods for administering medication at or near an intervertebral spinal disc are provided. In various embodiments, a microporous uninflated balloon is inserted into a spinal disk and after insertion of the balloon into the disc space, a medication is inserted into the interior of the balloon. Due to both the pressure on the balloon from the spine and drug diffusion, the medication moves through the pores over time.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: October 21, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8852150
    Abstract: A DC-AC frequency converter type nose cleaner includes an electromagnetic pump, a container storing a cleaning solution, a nose-washing tool and a frequency converter circuit driving the electromagnetic pump. The frequency converter circuit at least includes an oscillator circuit, a bistable circuit and a push-pull circuit. The swing speed, the swing frequency and the swing amplitude of the swing arms vary with the change of the oscillation frequency of the oscillator circuit. The DC-AC frequency converter type nose cleaner can change the pressure and the flow generated by the electromagnetic pump so as to satisfy the requirement of the discharge pressure and flow of the nose cleaner so as to overcome the defect of the discharge pressure of the conventional nose cleaner that is too big to hurt the user.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: October 7, 2014
    Inventor: Ming Yang Wang
  • Patent number: 8845577
    Abstract: An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: September 30, 2014
    Assignee: C.B. Fleet Company, Inc.
    Inventor: Charles H. Cox
  • Patent number: 8827957
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: September 9, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles George Hwang
  • Publication number: 20140228758
    Abstract: A rugged elastomeric infusion pump capable of storing sterile fluids under pressure for intravenous medical use within an elastomeric bladder, wherein said elastomeric bladder is surrounded by a rugged outer shell having a proximal and distal parts with respect to the elastomeric bladder, said distal part comprising one or more of a flow regulator, a modulator, and a flow meter for regulating, smoothing, and measuring the flow of fluids effused from the elastomeric bladder, wherein said rugged proximal parts are capable of absorbing impacts to minimize the force imparted to the elastomeric infusion pump.
    Type: Application
    Filed: June 22, 2012
    Publication date: August 14, 2014
    Applicant: COMBATIV INC.
    Inventors: Kevin Chi, Seth Robin Norman, Matthew James Tilleard
  • Publication number: 20140148761
    Abstract: A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.
    Type: Application
    Filed: September 26, 2011
    Publication date: May 29, 2014
    Applicant: STEADYMED, LTD.
    Inventors: Nir Rotem, Keren Fradkin, Jonathan Golstein
  • Patent number: 8696630
    Abstract: A reservoir for use in a wearable infusion device includes a substantially rigid base having a perimeter, a substantially rigid top having a perimeter, and a flexible rolling diaphragm between the base and the top. The diaphragm has an outer perimeter sealed along the perimeter of the base and an inner perimeter sealed along the perimeter of the top. The diaphragm is arranged to dispose the top and the base immediately adjacent each other when the reservoir is empty and to dispose the top and the base in spaced apart relation when the reservoir is full.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 15, 2014
    Assignee: Calibra Medical, Inc.
    Inventors: Brett J. Carter, Brett Cross, John McKenzie
  • Patent number: 8696648
    Abstract: A nasal aspirator comprising a resilient bulb and a stem for suction of liquids by vacuum created by compressing the bulb and thereafter gradually releasing the compression of the bulb, where the stem is removable connected to the bulb part, wherein the bulb part comprises a neck portion adopted to interact with a cap portion of the stem part to create a substantially airtight connection there between.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: April 15, 2014
    Assignee: Laerdal Medical AS
    Inventors: Tore Laerdal, Jens Petter Ianke, Kjell Ove Korneliussen
  • Patent number: 8684971
    Abstract: A peritoneal dialysis system is provided that includes a hardware unit, a disposable unit received by the hardware unit, and a controller. The hardware unit includes a recessed area, a piston having a contact surface, a pneumatic source for supplying a negative pressure, and an actuator configured to move the contact surface of the piston into and out of at least a portion of the recessed area. The disposable unit includes an outer member fitted at least partially within the recessed area of the hardware unit and a moveable membrane positioned between the contact surface of the piston and the outer member when the disposable unit is received by the hardware unit. The controller is configured to cause the pneumatic source to apply the negative pressure to the moveable membrane so as to conform the moveable membrane to a shape of the contact surface of the piston and follow the contact surface when the piston is moved towards and away from the outer member fitted at least partially within the recessed area.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: April 1, 2014
    Assignee: Baxter International Inc.
    Inventors: Donald D. Busby, Peter A. Hopping, Robert W. Childers, Rick E. Kienman, Ian Richardson
  • Patent number: 8684968
    Abstract: A hypodermic drug delivery apparatus for delivering a pressurized medication fluid generally incorporates a reservoir containing at least one deliverable fluid, a reservoir pressurizing device, a rupturing member, a fluid administration device for communicating with the reservoir via a fluid passageway, and a rupture control mechanism for preventing rupture of a wall portion of the reservoir below a threshold pressure.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: April 1, 2014
    Assignee: Aktivpak, Inc.
    Inventor: Amir Genosar
  • Patent number: 8679060
    Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 25, 2014
    Assignee: Asante Solutions, Inc.
    Inventors: Morten Mernoe, James Causey, Mitchell Wenger, Mark Estes
  • Patent number: 8679395
    Abstract: The invention relates to a medicament container, comprising a cavity at least partially defined by a container wall comprising a soft, flexible inner layer consisting of a soft material and a rigid outer layer consisting of a rigid material, wherein the layers are arranged as a one-piece part by two component injection molding.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: March 25, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Thomas Nagel, René Richter, Robert Witt
  • Patent number: 8617482
    Abstract: A capping device is configured to terminate a connector while disconnected from another connector in a fluid transportation system, e.g., for peritoneal dialysis. The connector comprises an exposed surface portion that is enclosed when the connector is connected to the other connector. The capping device comprises a body defining a chamber with an opening, a liquid-containing disinfectant in the chamber, a sealing element arranged in the opening to form a sealed cavity retaining the disinfectant, and a structure for engaging and guiding the connector towards the body such that a portion of the connector displaces the sealing element into the chamber. The sealed cavity is configured such that a displacement of the sealing element into the chamber actively presses the disinfectant out of the sealed cavity, for disinfecting at least part of the exposed surface portion.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: December 31, 2013
    Assignee: Gambro Lundia AB
    Inventors: Ragnar Tryggvason, Mikael Axelsson
  • Publication number: 20130345633
    Abstract: A fluid infusion device, for delivery of a medication fluid to the body of a user, includes a housing, a fluid reservoir for the medication fluid, a dosing mechanism, an infusion component, and a mechanical actuator. The fluid reservoir and the dosing mechanism are located in the housing, and the dosing mechanism is coupled to receive the medication fluid from the fluid reservoir. The dosing mechanism has an adjustable fluid chamber that defines a variable dosage volume. The infusion component is coupled to the dosing mechanism to receive the medication fluid from the adjustable fluid chamber. The mechanical actuator is coupled to the dosing mechanism such that operation of the mechanical actuator causes the medication fluid to be expelled from the adjustable fluid chamber to the infusion component.
    Type: Application
    Filed: June 26, 2012
    Publication date: December 26, 2013
    Applicant: MEDTRONIC MINIMED, INC.
    Inventor: Colin A. Chong
  • Patent number: 8613726
    Abstract: An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: December 24, 2013
    Assignee: Medtronic Minimed, Inc.
    Inventors: James D. Causey, III, William H. Stutz, Jr., Clyde K. Nason, Sheldon B. Moberg, Jay Yonemoto, Richard E. Purvis, Cary Talbot
  • Patent number: 8579850
    Abstract: An irrigation device that includes a reservoir for an irrigating liquid, a catheter in liquid communication with the reservoir, a fixation member for fixation of the catheter and a control unit. The control unit is arranged for in a first position transferring the irrigation liquid to the fixation member and in a second position transferring the irrigation liquid to the catheter. Thereby is provided a simple, inexpensive and essentially maintenance free device which can be used for administrating an irrigation liquid, and which at the same time comprises a fixation member that will not be expelled from the body cavity by e.g. a peristaltic reflex, during use.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: November 12, 2013
    Assignee: MBH-International A/S
    Inventor: Henrik Bork Bjerregaard
  • Patent number: 8579883
    Abstract: A body-insertable apparatus according to an aspect of the present invention is introduced into a subject to inject medical agent stored in a casing into a desired part in the subject. The body-insertable apparatus includes a fixing unit which fixes the casing to the desired part; and a projecting unit which projects, from the casing, an injection needle for injecting the medical agent. The fixing unit and the projecting unit are driven by a driving source.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: November 12, 2013
    Assignee: Olympus Corporation
    Inventors: Shinsuke Tanaka, Hironobu Takizawa, Hironao Kawano