Material Impelled By Means (e.g., Diaphragm, Piston) Moved By Gas Or Vacuum Pressure Patents (Class 604/141)
  • Patent number: 10646265
    Abstract: Disclosed herein is an apparatus for cooling a sterile liquid for use in cryotherapy, the apparatus comprising: a first chamber (202) adapted to receive a removable container (201) of sterile liquid and a fluid port for receiving a fluid for applying, in use, pressure to a received removable container (201); and a second chamber (203) comprising a cooler; wherein the first chamber (202) is arranged to be in thermal conductivity with the second chamber (203) such that, in use, the contents of the first chamber (202) are cooled by the cooler of the second chamber (203). Advantageously, embodiments provide a system, heat exchanger unit within the system and method for supplying a sterilised working fluid to a catheter system for cryotherapy, the working fluid being supplied at a desired and easily controllable temperature and flow rate.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: May 12, 2020
    Assignee: Cryotherapeutics GmbH
    Inventors: Stuart Robert Abercrombie, Duncan Aleck Bishop, Symon Cotton, Richard Day, Sylvain Bruno Jamais, Simon Karger, Andrew Lintott, Nathan Wrench
  • Patent number: 10610640
    Abstract: Fluid delivery and measurement systems and methods are disclosed.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: April 7, 2020
    Assignee: VALERITAS, INC.
    Inventors: Robert R. Gonnelli, Steven F. Levesque, David Lipson, Peter F. Marshall
  • Patent number: 10603428
    Abstract: A device (1) for dispensing a fluid, in particular to a patient, comprising a container (15), in particular an at least partly collapsible container, with an interior (17) for receiving the fluid. The container (15) comprises a closure piece (20) which is rigidly arranged in the container (15) in particular and on which a dispensing opening (24) is formed, wherein the fluid can be dispensed out of the interior (17) through the dispensing opening. The device (1) comprises a pump device (40) driven by a pump drive (50) in order to pump the fluid out of the interior (17) of the container (15). The pump device (40) is fluidically arranged between the interior (17) and the dispensing opening (24) so that the fluid can be pumped out of the interior (17) to the dispensing opening (24) by the pump device (40).
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: March 31, 2020
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventor: Ludwig Daniel Weibel
  • Patent number: 10561794
    Abstract: The invention relates to a needleless injection device, containing at least one membrane, or a corresponding device for needleless injection of a substance, having at least one membrane, with which a powdered, gel-like or liquid agent, in particular an active agent, can be injected in a needleless manner into a tissue or a body by means of high impact speed. The invention also relates to a method for such a needleless injection device containing a membrane, and use thereof.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: February 18, 2020
    Inventor: Peter Lell
  • Patent number: 10521561
    Abstract: An electronic drug compliance monitoring system and associated methods utilize a pill having an electronic transmission capability and external means for receiving that transmission to sense the presence of the pill in the patient's body or digestive tract.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: December 31, 2019
    Assignee: etectRx, Inc.
    Inventors: Neil Euliano, Eric Buffkin, Brent Arnold Myers, Glen Flores
  • Patent number: 10492887
    Abstract: Disclosed is a medicine ingestion state management method capable of objectively managing medicine ingestion states of patients. The medicine ingestion state management method involves an operation of prescribing medicine (10) encapsulating, together with a medicament, a medicine information transmitting unit (20) having a function of transmitting medicine information capable of specifying a type and a quantity of the medicament to each individual patient, and an operation of grasping the medicine ingestion state of each patient by collecting the medicine information from each medicine information transmitting unit (20) in each patient.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: December 3, 2019
    Assignee: FUJITSU LIMITED
    Inventors: Hitoshi Kimura, Morihito Notani
  • Patent number: 10322273
    Abstract: A device introduced small volumes of fluid for delivery to a patient through a fluid line. The device includes a first arm adapted to receive a syringe and a second arm fluidly connected to an upstream reservoir that defines an internal volume adapted to receive a volume of fluid. The device includes a fluid obstruction mechanism configured to selectably block flow of fluid from the reservoir toward the patient, wherein the fluid obstruction mechanism transitions between a first state that permits fluid flow from the reservoir toward the patient and a second state that directs fluid flow from the syringe into the reservoir while blocking fluid flow from the reservoir toward the patient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: June 18, 2019
    Assignee: CareFusion 303, Inc.
    Inventor: Robert Vasko
  • Patent number: 10314966
    Abstract: Systems and methods of micro-infusion of medical fluids are disclosed. Micro-infusion systems may include a pump, a patient interface, tubing between the pump and the interface, and a micro-infusion device along the tubing. A first portion of the tubing above the micro-infusion device is longer than a second portion of the tubing below the device. The micro-infusion device may include a chamber in-line with the tubing, a first valve between the chamber and the first portion of the tubing, a second valve between the chamber and the second portion of the tubing and a third valve between the chamber and a dump chamber. The second valve may be slidably disposed within the chamber. A medical fluid may be provided into the chamber that slides the second valve displacing another fluid in the chamber through the third valve into the dump chamber.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: June 11, 2019
    Assignee: CAREFUSION 303, INC.
    Inventors: Edward Browka, James Fentress, Lawrence Farhat, Robert Vasko, Theodore Mosler, David Foshee, George Mansour
  • Patent number: 10279156
    Abstract: Apparatus and methods to treat skin defects include a pump with reservoirs for a pressurization gas and a fluid. Upon activation, the pump generates a gas introduced into the gas reservoir, a movable wall of which displaces a movable wall of a fluid source, thus dispensing the fluid into the dressing to spread throughout irrespective of orientation of the dressing, maintaining a transport fluid (e.g. carrier) in the dressing and in contact with a skin defect being treated. The dressing may have a distribution network, and multiple members, dispensing the fluid into the dressing and in contact with a skin defect being treated.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 7, 2019
    Assignee: Aplion Medical, LLC
    Inventors: Sai Bhavaraju, John Howard Gordon, Jeremy Heiser, Ashok V Joshi, Troy C Dayton
  • Patent number: 10232108
    Abstract: Some embodiments of an infusion pump system may be configured to detect when at least one component of the pump system is exposed to an impact above a threshold level. In particular embodiments, the infusion pump system can be equipped with a drive system detection system configured to detect when one or more components of the drive system are damaged or inoperable.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 19, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Wenkang Qi, David Thrower, Tracy Brewer
  • Patent number: 10188809
    Abstract: A medical pump provides programming to assist a patient in complying with treatment schedules involving varying dosages of medicament(s). The pump includes stored treatment schedules and protocols that describe control of flow control device(s) for delivering different medicines according to the protocols and which may provide reminders and instructions to the patient.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: January 29, 2019
    Assignee: Zyno Medical, LLC
    Inventors: Chaoyoung Lee, Mei Zhang
  • Patent number: 10016217
    Abstract: Apparatus and methods may be provided to monitor performance of an intraosseous device, including a system comprising an intraosseous device, a sensor contained within a tip of the intraosseous device, a monitor configured to record a signal from the sensor, and an electrical conductor coupled to the sensor and configured to transmit the signal from the sensor to the monitor. The tip of the intraosseous device may be configured to penetrate bone and bone marrow such that the tip is disposed in the bone marrow. In certain embodiments, the tip may also include a side port for delivering fluids into the bone marrow.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: July 10, 2018
    Assignee: TELEFLEX MEDICAL DEVICES S.À.R.L.
    Inventor: Larry J. Miller
  • Patent number: 9675754
    Abstract: An autoinjector includes a main body having a container, the container having a drug therein, a hollow needle coupled to the container through which the drug can be delivered. The autoinjector also has a power source having a liquefied gas therein as a driver, a flow regulator, and at least one outlet through which some of the driver can exit the power pack in a gaseous state. The power source and container are coupled together for operation such that, when an injection is initiated, the flow regulator will control an exit rate of the driver such that the liquefied gas in the power source is maintained at substantially its vapor pressure and the power source will adjustably apply a force to deliver the drug via the hollow needle at a delivery rate that is a constant delivery rate.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: June 13, 2017
    Assignee: Nuance Designs, LLC
    Inventors: David DeSalvo, Carlos Guillermo
  • Patent number: 9622814
    Abstract: The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow is pulsatile to increase turbulence, reducing areas of stagnant flow, and produces a desired cooling effect.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 18, 2017
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventors: Huisun Wang, Jeremy D. Dando, Hong Cao
  • Patent number: 9610405
    Abstract: A medical device includes a first housing portion (FHP) and a second housing portion (SHP) configured to be to be movable relative to each other from a first position to operatively engage at a second position to couple at least one of a drive device and a needle-inserting device supported by one of the FHP and the SHP to a reservoir supported by the other of the FHP and the SHP. Electronic circuitry configured to detect at least one of a first magnetic interaction between a magnet and at least one of a first magnetically attractive material and a first magnet-responsive device and a second magnetic interaction between the magnet and at least one of a second magnetically attractive material and a second magnet-responsive device, and to provide a signal or a change in state in response to detecting at least one of the interactions.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: April 4, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Ian B. Hanson, Paul F. Bente, IV
  • Patent number: 9517307
    Abstract: An apparatus includes a container, a needle, and an actuation assembly. The container contains a dose of a naloxone composition having a delivered volume of at least about 0.34 mL. The actuation assembly includes an energy storage member that produces a force on a movable member to move the needle and to deliver the dose of the naloxone composition. The 90% confidence interval of at least one of the relative mean maximum naloxone plasma concentration after dose delivery into the body (Cmax), time to reach the maximum naloxone plasma concentration (Tmax), area under the plasma concentration-time curve from pre-dose (time 0) extrapolated to infinity (AUC0-?), or area under the plasma concentration-time curve from pre-dose (time 0) to the time of the last quantifiable concentration (Tlast) (AUC0-t) of the delivered dose to a delivered dose of a corresponding naloxone composition delivered via a manually-actuated syringe is within 80% to 125%.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: December 13, 2016
    Assignee: kaleo, Inc.
    Inventors: Frank E. Blondino, Eric S. Edwards, Evan T. Edwards, Glen L. Kelley, Paul F. Meyers
  • Patent number: 9462962
    Abstract: Embodiments of the invention include an implant having an energy converter, wherein the converter is designed to convert applied energy to heat. In embodiments of the invention, the energy converter is situated in such a way that heat generated from the energy conversion is active at an outer surface of the implant.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: October 11, 2016
    Assignee: BIOTRONIK SE & CO. KG
    Inventor: Thomas Doerr
  • Patent number: 9452248
    Abstract: An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 27, 2016
    Assignee: Smith & Nephew PLC
    Inventors: Patrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Derek Nicolini, Tina Michelle Walker, Julian Lee-Webb
  • Patent number: 9439667
    Abstract: Various types of supporting structures, supporting devices, attachment mechanisms and attachment techniques may be provided to support and/or stabilize an intraosseous device installed at a target site in a patient. Various methods and procedures may also be provided to releasably engage a supporting structure or supporting device proximate a target site. Apparatus and methods may be provided to monitor performance of an intraosseous device during communication of drugs, medications and/or fluids with an intraosseous space.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: September 13, 2016
    Assignee: Vidacare LLC
    Inventor: Larry J. Miller
  • Patent number: 9370616
    Abstract: An irrigation system for providing a continuous and controlled flow of a fluid. The system includes (a) a reservoir system having a main longitudinal axis and a plurality of containers of fluid; (b) a fluid transfer system in fluid connection with said reservoir system and includes at least one fluid transfer head, adapted to transfer fluid from one of said plurality of containers to an external tubing system; and (c) at least one connector between said container and said fluid transfer head. Each fluid transfer head has a mechanism adapted to linearly move each of said fluid transfer heads along said main longitudinal axis. Each container comprises a neck and a nipple. Each connector is reversibly coupled to said irrigation system and comprises: a lower section comprising two arcs, the distance between the centers of said arcs substantially equal to the distance between the centers of said neck and said nipple.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: June 21, 2016
    Assignee: FLOW MED LTD.
    Inventors: Ehood Nakash, Eliahu Eliachar, Lilach Nir, Ram Grossfield, Gil Tenennbaum, Izak Orbach
  • Patent number: 9345830
    Abstract: A pumping device that can be used with currently-available pressure bag infusers is disclosed. The pumping device is hand-held and lightweight. The device is controlled by a microprocessor. Thus constant pressure to the bag is maintained through automatic adjustment of pumping and venting functions. In addition, a novel, new pressure bag infuser and a modified Luer Lock fitting for use with the pumping device are described.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: May 24, 2016
    Assignee: Sprout Medical, Inc.
    Inventor: Paul Joseph Miller
  • Patent number: 9295779
    Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 29, 2016
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry Brian Gray, Eric Yeaton
  • Patent number: 9299238
    Abstract: Systems and related methods are provided for measuring a ketone in the fluid of a patient or other user. The systems include a portable measurement device for analyzing a plurality of fluid samples and for generating a corresponding plurality of ketone measurement results. The systems also include an electronic or communications device, for example, such as a cell phone or smartphone, configured to communicate with the measurement device. The system further includes a software application. The systems and related methods according to one aspect provide reminders, preferably interactive reminders that facilitate user compliance with a weight management or diabetic ketoacidosis (DKA) monitoring or prevention program. The systems and related methods according to another aspect incorporate ketone tags and/or trigger points to improve accuracy of results and to advance user compliance.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: March 29, 2016
    Assignee: Invoy Technologies, LLC
    Inventors: Lubna M. Ahmad, Salman A. Ahmad, Zachary Smith
  • Patent number: 9220833
    Abstract: A drug delivery system has a fluid store that has a first tubing having an outlet fitted with a connector of a given configuration that prevents the connector from being coupled to a conventional counterpart connector. The system further has a tube retaining device that has a catheter extending out of one of its ends and an inlet connector at its other end that has a configuration complementary to the configuration of the outlet connector of the first tubing, so that the first tubing may be matingly connected to the tube retaining device to establish a through fluid path from the first tubing to the catheter. A one-way valve may be provided to the tubing to prevent fluid from flowing backwards into the tubing. The tubing can be selectively occluded and opened to regulate the flow of fluid from the tubing to the catheter.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: December 29, 2015
    Assignee: SMITHS MEDICAL ASD, INC.
    Inventors: Renee Robert, Chad Amborn, Geoff Clark
  • Patent number: 9205024
    Abstract: An intravenous medication delivery safety assembly insures proper medication is delivered to a patient. The assembly includes an IV bag holding a medication. A tube has a first end coupled to the bag. A microchip is coupled to the tube proximate a second end of the tube. The microchip provides identifying data corresponding to the medication in the bag. A conduit is selectively coupled to the second end of the tube. The conduit is configured for coupling to a cannula. A security mechanism is coupled to the conduit to prevent coupling the tube to the conduit. A processor is coupled to the conduit and includes confirmation data corresponding to the patient to receive the medication. The processor reads the microchip and is operationally coupled to the security mechanism to permit coupling of the tube to the conduit only when the confirmation data properly corresponds to the identifying data.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: December 8, 2015
    Inventor: Joram O. Mogaka
  • Patent number: 9205188
    Abstract: An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: December 8, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Kevin L. Grant, Brian D. Tracey
  • Patent number: 9173994
    Abstract: A micropump device. The micropump device includes a first layer forming a first chamber configured to store a working material, a second chamber defined by a deflectable membrane in fluid communication with the first chamber and configured to deflect in response to a pressure increase in the first chamber in response to a volume increase in the first chamber, the second chamber configured to store a drug compound to be delivered to a subject's vascular system, and at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the drug compound in response to the deflection of the deflectable membrane.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: November 3, 2015
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Babak Ziaie, Manuel Ochoa, Charilaos Mousoulis
  • Patent number: 9132231
    Abstract: A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to undergo incremental advancement. The device may also be provided with manual control for delivering a bolus dose of drug when necessary.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 15, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Joseph Gross, Izrail Tsals, Gilad Lavi, Gil Yigal, Ehoud Carmel
  • Patent number: 9119912
    Abstract: A system for controlling pressurized infusion and temperature of intravenous fluids according to the present invention includes a housing, a heating assembly and a flexible cover. The heating assembly is recessed within the housing and includes a generally U-shaped configuration to surround and uniformly heat fluid within a fluid container placed thereon. The cover wraps around a portion of the fluid container to secure the fluid container against the heating assembly. The cover includes a pressurization member to apply a desired pressure to the fluid container to achieve a desired flow rate of intravenous fluid from the fluid container to an infusion site on a patient. The system further includes a controller to control the heating assembly and pressure within the pressurization member in accordance with desired temperature and pressure information entered into the controller for system operation.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: September 1, 2015
    Assignee: Medical Solutions, Inc.
    Inventors: Durward I. Faries, Jr., Bruce R. Heymann, Calvin Blankenship, David Hendrix
  • Patent number: 9114971
    Abstract: A self regulating and constant pressure maintaining product dispenser assembly comprises a dispensing device and a product container defining an inner space comprising a product space being filled with a fluid product constituting a carbonated beverage, and a pressure space being filled with a propellant gas having an initial pressure of preferably 0.5-1.8 bar above the atmospheric pressure when subjected to a specific temperature range of preferably 3° C.-50° C. The pressure space further comprises an amount of an adsorption material having adsorbed an amount of the propellant gas, which is sufficient for allowing the pressure space to increase in volume and to substitute the product space. The particular amount of adsorption material is inherently capable of substantially maintaining the initial pressure in the pressure space by releasing the propellant gas into the pressure space and adsorbing the propellant gas from the pressure space.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: August 25, 2015
    Assignee: CARLSBERG BREWERIES A/S
    Inventors: Jan Norager Rasmussen, Steen Vesborg
  • Patent number: 9067012
    Abstract: A rugged infusion device capable of exerting consistent pressure onto an IV bag for intravenous medical use, wherein said device and said IV bag are surrounded by a rugged outer shell having a proximal and distal parts with respect to the device, said distal part comprising one or more of a flow regulator, a modulator, and a flow meter for regulating, smoothing, and measuring the flow of fluids effused from the IV bag, wherein said rugged proximal parts are capable of absorbing impacts to minimize the force imparted to the rugged infusion device.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: June 30, 2015
    Assignee: CombatIV Inc.
    Inventors: Kevin Chi, Seth Robin Norman, Matthew James Tilleard
  • Patent number: 9050407
    Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: June 9, 2015
    Assignee: MINIPUMPS, LLC
    Inventors: Jason Shih, Changlin Pang, Fukang Jiang, Sean Caffey, Mark Humayun, Yu-Chong Tai, Raymond Peck
  • Publication number: 20150141918
    Abstract: A syringe propellable by propellant that boils at a predetermined temperature, the syringe including a barrel having an outlet at a front end, and a stopper axially moveable in the barrel. The stopper separates a first chamber and a second chamber, the first chamber being axially forwards of the stopper and being configured for containing a medicament, and the second chamber being axially rearwards of the stopper and being configured to receive propellant for acting on the stopper to move the stopper axially forwardly in the barrel to expel medicament through the outlet upon actuation of the syringe. The syringe further includes a rupturing portion and a third chamber for containing propellant where the third chamber is rupturable upon actuation of the syringe to fluidly connect the third chamber to the second chamber.
    Type: Application
    Filed: June 7, 2013
    Publication date: May 21, 2015
    Inventors: Ian Anderson, Matt Ekman, Rachel Suzanne Koppelman
  • Patent number: 8986253
    Abstract: Two chamber pumps and related methods provide a platform for measuring flow rate in about real time without contacting the material being pumped. Pressure and optional temperature sensors disposed in a pressurized chamber allow for flow material delivery calculations after being calibrated or by knowing the initial volume of the flow material to be delivered.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: March 24, 2015
    Assignee: Tandem Diabetes Care, Inc.
    Inventor: Paul M. DiPerna
  • Patent number: 8986244
    Abstract: A method of treating a prostate condition, including the steps of providing a needleless injector that includes a body at a proximal end, an injection shaft extending from the body to a distal end of the injection shaft, an injection orifice at the distal end of the injection shaft and positioned for fluid ejection in a lateral direction relative to a longitudinal axis of the injection shaft, a pressure source in communication with the fluid chamber, and an extendable tissue tensioner located at the distal end of the injection shaft proximal to the injection orifice; inserting the injection shaft into a urethra so the injection orifice is located within the prostatic urethra; actuating the tissue tensioner to contact urethral tissue, and injecting fluid from the injection orifice into the prostate.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: March 24, 2015
    Assignee: AMS Research Corporation
    Inventors: Vincent G. Copa, Sidney F. Hauschild
  • Patent number: 8979791
    Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 17, 2015
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
  • Publication number: 20150065997
    Abstract: Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.
    Type: Application
    Filed: November 10, 2014
    Publication date: March 5, 2015
    Inventors: Scott Uhland, Eric Peeters, Hussain Fatakdawala
  • Patent number: 8968243
    Abstract: A device for substance delivery to and/or extraction from the tympanic cavity, comprising: a stationary body having a distal surface, a proximal surface; a movable body having a distal surface and a proximal surface, disposed within the stationary body and free to move relative to the stationary body; at least one piercing element having a distal end and a proximal end, disposed in the movable body; and a means for moving the movable body relative to the stationary body.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: March 3, 2015
    Assignee: EntraTympanic, LLC
    Inventors: Lev Rosenblum, Christian Pfeffer, George Kenney
  • Patent number: 8920377
    Abstract: An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: December 30, 2014
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards
  • Patent number: 8920376
    Abstract: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: December 30, 2014
    Assignee: MiniPumps, LLC
    Inventors: Sean Caffey, Po-Ying Li, Yu-Chong Tai, Jeffrey Brennan
  • Patent number: 8920375
    Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; a reservoir for delivery of drugs; a gas source, and, optionally, pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: December 30, 2014
    Assignee: Valeritas, Inc.
    Inventor: Robert R. Gonnelli
  • Patent number: 8915893
    Abstract: An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump and a programmable module. The module may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the flow rate, electronics for analyzing the flow rate information, and a mechanism for physically altering the flow rate. In certain embodiments, the module includes a hermetically sealed housing. Methods of dispensing a medicament to a patient utilizing such a system are also disclosed, as are variations of the pump system.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: December 23, 2014
    Assignee: Palyon Medical (BVI) Limited
    Inventor: Bernd Steinbach
  • Patent number: 8905966
    Abstract: The present invention relates to a novel type of a needle-free drug delivery system in which strong energy such as a laser beam is focused inside liquid contained in a sealed pressure chamber to cause bubble growth and the volume expansion in the sealed pressure chamber due to the bubble growth so as to elongate an elastic membrane, so that an instantaneous pressure is applied to a drug solution contained in a drug microchamber adjacent to the elastic membrane to allow the drug solution to be injected in the form of a liquid microjet, thereby enabling the drug solution to rapidly and accurately penetrate into the bodily tissues of the patient.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: December 9, 2014
    Assignee: SNU R & DB Foundation
    Inventors: Jai-Ick Yoh, Tae-Hee Han
  • Patent number: 8852151
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: October 7, 2014
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 8834454
    Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
    Type: Grant
    Filed: May 6, 2007
    Date of Patent: September 16, 2014
    Assignee: SteadyMed Ltd.
    Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
  • Patent number: 8814829
    Abstract: A syringe assembly for connecting to an intravenous (“IV”) line includes: a syringe barrel having an actuation end and a discharge end; a syringe plunger moveable within the syringe barrel, the syringe plunger including a plunger head connected to a plunger arm; a seal between the plunger arm and the syringe barrel, the seal residing on an actuation end side of the syringe plunger; and a tube in fluid communication with the syringe barrel at a location between the seal and the plunger head, the tube having a distal end configured to be connected to the IV line.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: August 26, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Birendra K. Lal
  • Patent number: 8808232
    Abstract: A needleless injector including a body including a fluid chamber; an outer shaft extending from an outer shaft proximal end to an outer shaft distal end, wherein the outer shaft includes an outer shaft lumen to accommodate an injection shaft; an injection shaft located within the outer shaft lumen and moveable lengthwise and/or rotationally within the outer shaft lumen, wherein the injection shaft includes an injection shaft proximal end, an injection shaft distal end, an injection shaft terminus, and an injection lumen. The injector further includes an injection orifice at the distal end of the injection shaft and in fluid communication with the fluid chamber through the injection lumen; a pressure source in communication with the fluid chamber; and an optical device that allows viewing a location at a distal end of the device.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: August 19, 2014
    Assignee: AMS Research Corporation
    Inventors: Vincent G. Copa, Sidney F. Hauschild
  • Patent number: 8753311
    Abstract: An improved propellant pillow and method for filling a propellant chamber of an implantable pump with propellant through the use of such an improved propellant pillow are disclosed. The propellant pillow includes an improved design that prevents the damage of such during evacuating and filling procedures.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: June 17, 2014
    Assignee: Palyon Medical (BVI) Limited
    Inventors: Bernd Steinbach, Falko Bitz
  • Patent number: 8708958
    Abstract: A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: April 29, 2014
    Inventors: Ducksoo Kim, Joseph L. Smith, Jr., James A. Crunkleton
  • Publication number: 20140114250
    Abstract: An autoinjector includes a main body having a container, the container having a drug therein, a hollow needle coupled to the container through which the drug can be delivered. The autoinjector also has a power source having a liquefied gas therein as a driver, a flow regulator, and at least one outlet through which some of the driver can exit the power pack in a gaseous state. The power source and container are coupled together for operation such that, when an injection is initiated, the flow regulator will control an exit rate of the driver such that the liquefied gas in the power source is maintained at substantially its vapor pressure and the power source will adjustably apply a force to deliver the drug via the hollow needle at a delivery rate that is a constant delivery rate.
    Type: Application
    Filed: October 22, 2013
    Publication date: April 24, 2014
    Applicant: Nuance Designs, LLC
    Inventors: David DeSalvo, Carlos Guillermo