Material Impelled By Pressurized Charge Of Gas Or Vacuum Patents (Class 604/140)
  • Patent number: 11131616
    Abstract: A system and method of using the system for analyzing liquid samples obtain from viscous sources. The system includes a sample delivery system, a particle counter configured to receive a liquid sample from the liquid sample delivery system, a composition analyzer configured to receive the liquid sample from the particle counter, a feed system configured to draw the liquid sample through the particle counter and subsequently inject the liquid sample into the composition analyzer; and a processor to process and analyze data from the particle counter and composition analyzer.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: September 28, 2021
    Assignee: PerkinElmer Health Sciences Canada, Inc.
    Inventors: Chady Stephan, David Hilligoss
  • Patent number: 11090437
    Abstract: The present invention will provide a medical device that can properly regulate the working pressure of a highly pressurized gas for delivering therapeutic agents at a relatively constant flow rate during the entire course of infusion while also maintaining the integrity of the operating room and reducing risks involved with therapeutic agents. This is accomplished utilizing a pressure control assembly along with a syringe assembly or self-contained fluid chamber to administer therapeutic agents to patents in a controlled and safe manner by incorporating pressurized gas.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: August 17, 2021
    Inventor: Patrick Lynch
  • Patent number: 11078259
    Abstract: The invention provides methods and compositions relating to molecular targets identified as being capable of increasing or decreasing thermogenic potential in cells, including preadipocytes. Included in the invention are methods and compositions relating to inhibiting or suppressing the activity of an uncoupling protein 1 (UCP1) negative regulator, such as cardiac actin 1 (ACTC1), somatostatin receptor 1 (SSTR1), FAT atypical cadherin 1 (FAT1), and protein tyrosine phosphatase receptor type B (PTPRB). Also included in the invention are methods and compositions relating to activating a UCP1 positive regulator, such as phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (PREX1), cortactin binding protein 2 (CTTNBP2), doublesex and mab-3-related transcription factor-like family A1 (DMRTA1), and endothelin receptor type B (ENDRB). The invention also provides methods and compositions relating to enrichment of cells having thermogenic potential based on cell surface markers, e.g.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: August 3, 2021
    Assignee: Joslin Diabetes Center, Inc.
    Inventors: Yu-Hua Tseng, Matthew Lynes, Ruidan Xue
  • Patent number: 10967127
    Abstract: This pharmaceutical injection device may be provided with a main body case, a pharmaceutical syringe mounting portion, a piston, a piston feed screw or the like, and a cover. At a first end, the main body case may have an injection needle mounting portion to which an injection needle is mounted. The pharmaceutical syringe mounting portion may be provided inside the main body case, and a pharmaceutical syringe may be mounted thereto. The piston may be provided movably with respect to the pharmaceutical syringe that is mounted to the pharmaceutical syringe mounting portion. The piston feed screw or the like drives the piston. The cover may be provided on the first end side of the main body case and operates to open and close the injection needle mounting portion.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: April 6, 2021
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Kenji Murakami, Mitsuteru Fujimoto
  • Patent number: 10561826
    Abstract: A catheter insertion device, including a housing having a base (504, 604, 704), a flexible beam (510, 610, 710) movably disposed within the housing, an insertion needle (514, 614) connected with the beam, and a holder (518, 618, 718) movably disposed within the housing and movably connected with the insertion needle. The device also includes a catheter (522, 622, 722) connected with the holder to displace therewith, the catheter surrounding at least a portion of the insertion needle, and an actuator button (502, 602, 702) movably connected to the housing and configured to flex the beam upon actuation, thereby displacing the insertion needle and the catheter to an extended position in which respective distal portions of the insertion needle and the catheter extend outside the housing through the base.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: February 18, 2020
    Inventors: Shuichi Amano, Russell Cole
  • Patent number: 10398854
    Abstract: An injector such as a needle-type autoinjector having a flexible flange disposed at an injection end of the injector for stretching or pinching the skin of the injection site. The flexible flange may be removably attached to the injector or integrated into the injector during manufacturing. Further, an injector having a palm button disposed at an activation end of the injector for activating an injection cycle of the injector. The palm button may be removably attached to the injector or integrated into the injector during manufacturing. Still further, a holding device for one-handed operation of an injector, the holding device having a sleeve and at least one hand rest coupled to the sleeve, the sleeve and hand rest providing ergonomic holding and operation of the injector. Still further, autoinjector needle shield having an enlarged, rounded lip for contacting the skin at the injection site.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: September 3, 2019
    Assignee: AMGEN INC.
    Inventors: Valerie M. Fenster, Stephanie Toy, Mark Ka Lai Lee, Denise Meyer
  • Patent number: 10251675
    Abstract: According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 9, 2019
    Assignee: Edge Systems LLC
    Inventors: Roger Ignon, Ed F. Nicolas, Scott R. Mallett
  • Patent number: 10245389
    Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: April 2, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Larry B. Gray, Eric Yeaton
  • Patent number: 9805620
    Abstract: An apparatus includes a simulated medicament delivery device and an electronic circuit system coupled to the simulated medicament delivery device. The electronic circuit system is configured to output an electronic output associated with a use of the simulated medicament delivery device.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: October 31, 2017
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards, Mark J. Licata, Paul F. Meyers, T. Spencer Williamson, Kai R. Worrell, David A. Weinzierl
  • Patent number: 9669085
    Abstract: The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus (PRRSV). Described herein are immunological and/or vaccine compositions comprising a DNA vector encoding a PRRSV protein, particularly a truncated ORF7 protein, which are administered to porcines using needle-free delivery. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: June 6, 2017
    Assignees: MERIAL INC., Chulalongkorn University
    Inventors: Sanipa Suradhat, Jean-Christophe Audonnet, Catherine Charreyre
  • Patent number: 9662449
    Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: May 30, 2017
    Assignee: Zogenix, Inc.
    Inventors: Brooks M. Boyd, Jeffrey A. Schuster
  • Patent number: 9649421
    Abstract: A method for controlling or regulating the pressure, which prevails within a heating bag of a tubing system used for the treatment, wherein the method encompasses the steps: Determining the pressure; comparing the determined pressure with a reference pressure or detecting its state with respect to a reference pressure range and changing a treatment parameter of the treatment of the patient or suggesting a correction of the treatment parameter in case the determined pressure is below or above, respectively, the reference pressure or outside the reference pressure range.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: May 16, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Jürgen Klewinghaus
  • Patent number: 9492616
    Abstract: A medicament delivery device is shown for the administration of one or more drug agents. The device comprises a medicament cartridge retainer for holding a medicament cartridge. A dispense interface can be attached to an attachment of the device for facilitating fluidic communication from the device. Further, an interface sensor is configured to provide an output indicative of whether the dispense interface is attached to the attachment. The device also comprises a piston rod for driving a bung of the medicament cartridge, and a drive train for advancing the piston rod to the bung. A controller is configured to control the drive train to advance the piston rod towards the bung when the output of the interface sensor indicates that the dispense interface is not on the attachment. The controller is further configured to disable advancement of the piston rod when the output of the interface sensor indicates that the dispense interface is at least partially on the attachment.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: November 15, 2016
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Ilona Eggert, Christopher Nigel Langley, Shane Alistair Day
  • Patent number: 9480597
    Abstract: Described is an apparatus for intraocular injection comprising a body adapted to accommodate a syringe having a needle, an outer sleeve telescopically coupled to the body, and at least two arms hingedly coupled to the outer sleeve. Each of the arms comprises a medial portion adapted to encase at least a portion of the needle. When the body moves distally relative 10 to said outer sleeve, the body engages the arms separating the medial portions.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: November 1, 2016
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Alastair Robert Clarke, David Heighton
  • Patent number: 9370620
    Abstract: The present invention relates to a method for determining start timing of supply of drug to be given in which a peripheral circulatory function and an autonomic nervous function are activated through a stimulus applied to a stimulus application origin part of a body surface by an acupuncture needle or warm heating etc., and a drug conveyance system according to the method for determining start timing of supply of drug.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: June 21, 2016
    Inventor: Kenji Ryotokuji
  • Patent number: 9339603
    Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: May 17, 2016
    Assignee: DEKA Products Limited Partnership
    Inventors: Larry B. Gray, Eric Yeaton
  • Patent number: 9095656
    Abstract: A medium- and high-pressure pulsed jet generator (1) for injecting controlled volumes of at least one medical liquid (7) includes a high-pressure chamber (2) and at least one connector (24) for at least one flexible pouch containing the medical liquid. The flexible pouch/es (6) is/are connected, via a connection tube, to a hydraulic sequencer (28) which is mounted in the high-pressure chamber, is exposed to the pressure inside the chamber (2), sequences the liquid discharged from the flexible pouch into a pulsed jet (11), is composed of a hydraulic connection (20) that is designed as or includes a deformable flexible sleeve (29) hydraulically communicating with the pouch/es (6) at the inlet and with a hand-held intervention element (40) or a catheter at the outlet, and includes hydraulic stops (31, 32) that are disposed on both sides of the flexible deformable sleeve (29) and are operated using a control element (33).
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: August 4, 2015
    Assignee: NESTIS
    Inventors: Danièle Lesueur-Gonon, Nicolas Gonon
  • Publication number: 20150112263
    Abstract: The present disclosure relates to fluid delivery devices for supplying a fluid, e.g., a flush medium, to a medical device, e.g., a vascular access device, inexpensively. The fluid delivery device includes a collapsible body defining a fluid reservoir and a connector for securing the fluid delivery device to the medical device. The collapsible body can include a bellows or pleated structure. In addition, structure including levers or plungers can be provided to collapse the body.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 23, 2015
    Inventors: Kathleen Tremblay, Scott M. Jones, Gregory A. Steube, Stephen B. Earheart, Kevin R. Martz, Mark Baker
  • Publication number: 20150051548
    Abstract: A method of making a delivery device (10) for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer (20) across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 19, 2015
    Inventor: Christophe Bureau
  • Patent number: 8920376
    Abstract: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: December 30, 2014
    Assignee: MiniPumps, LLC
    Inventors: Sean Caffey, Po-Ying Li, Yu-Chong Tai, Jeffrey Brennan
  • Patent number: 8920377
    Abstract: An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: December 30, 2014
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards
  • Patent number: 8919384
    Abstract: The fluid delivery system includes a pressurizing device for delivering a pressurized injection fluid, a low pressure fluid delivery system, and a pressure isolation mechanism adapted for fluid communication with the pressurizing device and low pressure fluid delivery system. The pressure isolation mechanism includes a housing body defining an inlet port, an isolation port, and an internal cavity, where the housing body defines a seal seat in the internal cavity between the inlet port and isolation port. A valve member is free floating in the internal cavity and is adapted to engage the seal seat. The valve member has an open position permitting fluid communication between the inlet port and isolation port, and is fluid flow responsive to fluid flow in the inlet port to engage the seal seat and attain a closed position preventing fluid communication between the inlet port and isolation port.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: December 30, 2014
    Assignee: Bayer Medical Care Inc.
    Inventors: Michael A Spohn, John A Haury
  • Publication number: 20140371674
    Abstract: An implantable device has an outer shell that includes an aperture through the housing of the device and, spanning the aperture, a membrane structure permeable to gas but not to liquid. In this way, excess gas may be vented from the device. The membrane and aperture are designed to discourage or even prevent tissue ingrowth.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 18, 2014
    Inventors: Bin Wang, Jason Shih, Gregory Harbers, Fukang Jiang, Sean Caffey
  • Patent number: 8905966
    Abstract: The present invention relates to a novel type of a needle-free drug delivery system in which strong energy such as a laser beam is focused inside liquid contained in a sealed pressure chamber to cause bubble growth and the volume expansion in the sealed pressure chamber due to the bubble growth so as to elongate an elastic membrane, so that an instantaneous pressure is applied to a drug solution contained in a drug microchamber adjacent to the elastic membrane to allow the drug solution to be injected in the form of a liquid microjet, thereby enabling the drug solution to rapidly and accurately penetrate into the bodily tissues of the patient.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: December 9, 2014
    Assignee: SNU R & DB Foundation
    Inventors: Jai-Ick Yoh, Tae-Hee Han
  • Publication number: 20140343494
    Abstract: The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user.
    Type: Application
    Filed: May 30, 2014
    Publication date: November 20, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: John D. Hoekman, Rodney J.Y. Ho
  • Publication number: 20140316214
    Abstract: Devices and methods for performing in vitro fertilization (“IVF”) and maximizing successful fertilization rates by optimizing the fluid flow conditions under which zygotes are transferred from growth medium to the uterine wall. The apparatus has a control unit with an external port and an internal pump for creating positive and negative fluid pressure at the port. A flexible extension hose connects the port to an inter-uterine catheter assembly. The catheter assembly has an inner catheter and an outer sheath surrounding the inner catheter. The control unit includes a programmable microprocessor that accepts input commands and controls operation of the pump. Optionally, the control unit has remote control means for activating, de-activating, and reversing the flow of the pump. The control unit can be programmed to repeatedly provide the same aspiration and expulsion flow conditions through the catheter assembly.
    Type: Application
    Filed: December 18, 2013
    Publication date: October 23, 2014
    Inventors: Michael E. Drummond, Nicholas M. DiTrolio
  • Publication number: 20140276587
    Abstract: Embodiments of the invention provide infusion systems for the intravenous or other delivery of drugs and other therapeutic agents to a patient including a human or mammal. The therapeutic agents may be dissolved in solution or comprise the solution itself. Embodiments of the systems can utilize a chemical reaction to predictably drive a flow of drug(s) through a catheter or other flow path and into the patient. More specifically, the reaction may include an acid-base reaction or any other reaction that produces a gaseous substance. The gas is produced and contained in an expandable drive balloon when the acid-base reactants are combined with a liquid. As the gas is produced, the drive balloon expands to exert pressure on a separately-contained drug reservoir which, in turn, pushes drug(s) from the reservoir into the flow path where the drug is ultimately delivered to the patient in a controlled and predetermined manner.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: InCube Labs, LLC
    Inventor: Mir Imran
  • Publication number: 20140221913
    Abstract: A low profile and volumetrically efficient medication delivery device configured to be placed on the body of a patient during fluid delivery to the patient is provided. The device incorporates a low profile actuator assembly that causes fluid delivery by displacing a collapsible reservoir in response to receiving an electrical current or charge input from a programmable controller and a power supply. Additional components help prevent drug theft or abuse, measure actuator pressure, displacement and temperature in real time providing active feedback to the controller that is controlling the actuator. The device also has wireless communication capabilities.
    Type: Application
    Filed: September 25, 2012
    Publication date: August 7, 2014
    Applicant: Medipacs, Inc.
    Inventors: Mark Banister, Raymond Clark, Erich Coiner, Yordan M. Geronov, Mark D. McWilliams, Ralph Sias, Mark Van Veen, Gary Walters
  • Publication number: 20140193907
    Abstract: Described here are devices and methods for the delivery of molecules, including biologically active molecules, into tissues. The devices and methods are generally particle based, and devised to deploy the molecules into a target tissue in a controlled manner to minimize tissue damage. The devices and methods may further be devised to tailor molecule delivery parameters to a variety of tissue types. Kits including various device components are also described.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 10, 2014
    Applicant: Bay Genomics, LLC
    Inventors: Kenneth GREENBERG, Scott GELLER
  • Publication number: 20140188048
    Abstract: An apparatus includes a housing, a needle, a first energy storage member and a second energy storage member. The needle is movably disposed within the housing and is configured to be to be placed in fluid communication with a medicament container. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The first energy storage member is disposed within the housing, and is configured to produce a first force when actuated. The second energy storage member is disposed within the housing, and is configured to be actuated in response to the first force to produce a second force to move the needle from the first needle position to the second needle position.
    Type: Application
    Filed: December 16, 2013
    Publication date: July 3, 2014
    Applicant: INTELLIJECT, INC.
    Inventors: Eric S. EDWARDS, Evan T. EDWARDS, Mark J. LICATA, Paul F. MEYERS
  • Patent number: 8758299
    Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: June 24, 2014
    Assignee: Antares Pharma, Inc.
    Inventors: Peter L. Sadowski, Paul R. Lesch, David Bremseth
  • Patent number: 8753311
    Abstract: An improved propellant pillow and method for filling a propellant chamber of an implantable pump with propellant through the use of such an improved propellant pillow are disclosed. The propellant pillow includes an improved design that prevents the damage of such during evacuating and filling procedures.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: June 17, 2014
    Assignee: Palyon Medical (BVI) Limited
    Inventors: Bernd Steinbach, Falko Bitz
  • Publication number: 20140148757
    Abstract: A system for controlled delivery of medicinal fluid includes a fluid pathway assembly defining a fluid pathway and including means for calculating a first calculated fluid flow rate using gas laws. The fluid pathway assembly has an inline flow sensor element received within the fluid pathway movable in response to fluid flowing in the fluid pathway. A flow control device is removably attached to the fluid pathway assembly and has a sensor for sensing a position of the inline flow sensor element in the fluid pathway, the position of the inline flow sensor element being representative of a second calculated fluid flow rate. The fluid pathway assembly includes a variable flow resistor adjustable to regulate a rate of fluid flow in the fluid pathway assembly. A drive mechanism attached to the flow control device is operably coupled to the variable flow resistor when the flow control device is attached to the fluid pathway assembly.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Inventors: Jesse E. Ambrosina, Benjamin G. Powers
  • Patent number: 8734384
    Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: May 27, 2014
    Assignee: Zogenix, Inc.
    Inventors: Brooks Boyd, Jeffrey A. Schuster
  • Publication number: 20140114248
    Abstract: A power pack, for use in an autoinjector to deliver a drug from a container at an injection rate includes a power pack body configured to hold a liquefied gas and a flow regulator, the power pack body further including at least one outlet through which some of the liquefied gas can exit the power pack in a gaseous state such that, during use, the flow regulator will control a rate of exit flow such that the liquefied gas in the canister is maintained at substantially its vapor pressure, while the gas leaving the outlet applies an adaptively changing force to the drug in the container so that delivery of the drug will occur at about a constant injection rate.
    Type: Application
    Filed: October 22, 2013
    Publication date: April 24, 2014
    Applicant: Nuance Designs, LLC
    Inventors: David DeSalvo, Carlos Guillermo
  • Publication number: 20140114211
    Abstract: An improved, injection or blood removal device for intravenous access has a port with a septum at the exterior end of an intravenous catheter, a coupling element having an adhesive surface for securing attachment onto the skin, an injection or blood sampling unit, a connecting cannula piercing the septum of the port, and means to secure functional assembly. Attachment of the device to the skin covering or close to the intravenous puncture site and without long communicating tubes allows ambulant injection of drugs or measuring of concentration-time profiles of exogenous and endogenous analytes to improve treatment modalities on an individualized basis.
    Type: Application
    Filed: March 28, 2012
    Publication date: April 24, 2014
    Inventors: Paul Hadváry, Hansjörg Tschirky
  • Patent number: 8690827
    Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: April 8, 2014
    Assignee: kaleo, Inc.
    Inventors: Evan T. Edwards, Eric S. Edwards, Mark J. Licata
  • Patent number: 8684970
    Abstract: A therapeutic apparatus for treating body tissue comprises a vessel enclosing a detonation chamber into which a detonatable mixture is introduced and then detonated using an igniter to form at least one shockwave and/or acoustic wave. A wave guide assembly having a converging geometry directs the wave to a tip of the wave guide assembly that is placed in contact with tissue to be treated by the wave. The wave guide assembly may include a wave focusing section surrounding the vessel, a flexible conduit connected to the wave focusing section and a needle connected to the conduit and sized for insertion into patient tissue to be treated. A cap connected to the end of the needle is formed from material permitting the wave or waves generated in the detonation chamber to pass therethrough to treat the patient tissue into which the needle is inserted.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: April 1, 2014
    Assignee: Medical Shockwaves Inc.
    Inventors: Yakov U. Koyfman, Gabriel Eidelman
  • Publication number: 20140081237
    Abstract: Devices and methods are provided for aspirating adipose tissue with a portable device. This device may include a processing chamber, a cannula, a vacuum source, a filter or screen for separating connective tissue strands from adipose tissue, a digestion area, and a product cell concentration chamber.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 20, 2014
    Applicant: TISSUE GENESIS, INC.
    Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
  • Publication number: 20140074017
    Abstract: The present disclosure relates in general to an apparatus and method for priming a liquid or surgical cassette. In one embodiment, an infusion system within the liquid cassette is primed using a forward flow of a liquid and a backward flow of the liquid. The forward flow of the liquid creates a first volume of liquid stored within an infusion conduit, which is connected to an infusion chamber via a first valve. The infusion conduit has an infusion port exposed to a non-liquid environment having a first pressure. A second pressure is created in the infusion chamber that is lower than the first pressure. Opening the first valve causes a second volume of liquid within the infusion conduit to flow over the first valve and towards the infusion chamber. The second volume of liquid is less than or equal to the first volume of liquid.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 13, 2014
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Shawn X. Gao, Roderick S. Van
  • Publication number: 20140046294
    Abstract: A device and method for dispensing a liquid with a gas includes an instrument having a cannula and a low-pressure tip. The low-pressure tip includes a tip housing that at least partially defines a high pressure chamber. A distal wall of the tip housing includes an aperture in fluid communication with the high pressure chamber. The low-pressure tip also includes a tube and a gas flow channel. The tube fluidly communicates liquid at a relatively low pressure from the cannula through the first aperture. The gas flow channel fluidly communicates gas from the cannula at a relatively high pressure and to the high pressure chamber for discharge from the aperture. The tube and aperture are adapted to dispense the liquid and the gas in order to create a low pressure zone distal of the tube to dispense droplets of the liquid.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 13, 2014
    Applicant: NORDSON CORPORATION
    Inventors: Thomas A. Kirk, Bradley D. Robb, Todd W. Sharratt
  • Publication number: 20140039384
    Abstract: Different embodiment programmable pumps including multiple reservoirs are disclosed, as are methods of utilizing same. The pumps generally include at least two reservoirs and means for dispensing active substances housed in each at varying flow rates.
    Type: Application
    Filed: October 16, 2013
    Publication date: February 6, 2014
    Applicant: PALYON MEDICAL (BVI) LIMITED
    Inventor: Bernd Steinbach
  • Publication number: 20140031789
    Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 30, 2014
    Applicant: INTELLIJECT, INC.
    Inventor: Intelliject, Inc.
  • Patent number: 8613726
    Abstract: An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: December 24, 2013
    Assignee: Medtronic Minimed, Inc.
    Inventors: James D. Causey, III, William H. Stutz, Jr., Clyde K. Nason, Sheldon B. Moberg, Jay Yonemoto, Richard E. Purvis, Cary Talbot
  • Patent number: 8608698
    Abstract: An apparatus includes a housing, a needle, a first energy storage member and a second energy storage member. The needle is movably disposed within the housing and is configured to be to be placed in fluid communication with a medicament container. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The first energy storage member is disposed within the housing, and is configured to produce a first force when actuated. The second energy storage member is disposed within the housing, and is configured to be actuated in response to the first force to produce a second force to move the needle from the first needle position to the second needle position.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: December 17, 2013
    Assignee: Intelliject, Inc.
    Inventors: Eric Shawn Edwards, Evan Thomas Edwards, Mark J. Licata, Paul F. Meyers
  • Patent number: 8608642
    Abstract: An environmentally sensitive hydrogel material swells or collapses in response to a parameter such as pH level associated with consumption of food by a patient. This swelling or collapsing is harnessed to treat morbid obesity or some other condition of the patient. The swelling or collapsing of the hydrogel may be used to tighten a gastric band or gastric valve when the patient starts eating; then loosen the band or valve when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to increase the size of a space occupying device in the patient's stomach when the patient starts eating; then decrease the size of the space occupying device when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to selectively restrict the absorption of nutrients within a patient's gastrointestinal tract, such as in the duodenum.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: December 17, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Janna M. Burrell, Randal T. Byrum, Robert Louis Koch, Jr., Larry D. Pool, Christopher W. Widenhouse
  • Patent number: 8551053
    Abstract: A receptacle of an elastically flexible plastic includes a dosing chamber (10) with a medium to be discharged. One end of the dosing chamber (10) has a discharge opening (18). The opposite end is connected via a junction point (20) to a compressible receptacle part (22) with a gaseous propelling medium. When compressing the receptacle part (22), the propelling medium forces the medium to be discharged out of the dosing chamber (10) via the discharge opening (18). The junction point (20) between the dosing chamber (10) and the receptacle part (22) is a bottleneck creating a capillary effect independent of the spatial position of the receptacle preventing transfer of the medium of the dosing chamber (10) into the receptacle part (22).
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: October 8, 2013
    Inventor: Bernd Hansen
  • Publication number: 20130197475
    Abstract: An injector for delivering medicament comprises a collapsible container (1002) for containing the liquid medicament, a normally-closed valve (1004) coupled to the collapsible container (1002) for retaining the liquid medicament within the collapsible container and an injection means (1006) for delivering the liquid medicament from the collapsible container. The liquid medicament is maintained under pressure by a pressurising means (1003) which pressurises the liquid medicament such that it is delivered by the injection means (1006) when the normally-closed valve (1004) is opened.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 1, 2013
    Applicant: NEW INJECTION SYSTEMS LTD
    Inventor: Stephen Terence Dunn
  • Patent number: 8486002
    Abstract: Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 16, 2013
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Patent number: 8480656
    Abstract: A dispensing device for dispensing medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: July 9, 2013
    Assignee: BioQuiddity, Inc.
    Inventor: Marshall S. Kriesel