Pressurizing Gas Generated By Chemical Reaction Patents (Class 604/145)
  • Patent number: 10426486
    Abstract: A vaso-occlusive device delivery assembly includes a pusher assembly and a vaso-occlusive device detachably coupled to the pusher assembly by an attachment member is frictionally secured within a lumen of the pusher assembly. A heat generating member is disposed in the pusher assembly lumen, along with a pressure generating material, such that, when heat is generated by the heat generative device, the pressure generating material increases a pressure in the pusher assembly lumen, thereby dislodging the attachment member from the pusher assembly and detaching the vaso-occlusive device from the pusher assembly.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 1, 2019
    Assignees: STRYKER CORPORATION, STRYKER EUROPEAN HOLDINGS I, LLC
    Inventors: Lantao Guo, Hancun Chen, Richard Murphy
  • Patent number: 8834454
    Abstract: The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
    Type: Grant
    Filed: May 6, 2007
    Date of Patent: September 16, 2014
    Assignee: SteadyMed Ltd.
    Inventors: Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
  • Patent number: 8734429
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 27, 2014
    Assignee: Rani Therapeutics, LLC
    Inventors: Mir Imran, Peter Herrmann, Baber Syed, Timothy H. Williams, Chang Jin Ong, Greg Method
  • Publication number: 20140128833
    Abstract: A device releases a fluid active substance, the device has at least one hollow space containing the fluid active substance, whereby the device contains water and a reducing agent, which are or can be made to be in communication such that a chemical reaction of the water and the reducing agent produces a gas and the gas effectively communicates with the fluid active substance such that the gas pressure thus generated presses the fluid active substance out of at least one opening of the hollow space out of the device. A medical implant incorporates the device, and a method releases a fluid active substance from a hollow space of the medical implant, in which a gas is produced through a chemical reaction of liquid water and a reducing agent, and the resulting gas pressure is used to expel the fluid active substance out of at least one opening of the hollow space.
    Type: Application
    Filed: October 29, 2013
    Publication date: May 8, 2014
    Applicant: HERAEUS MEDICAL GMBH
    Inventor: Sebastian Vogt
  • Patent number: 8684970
    Abstract: A therapeutic apparatus for treating body tissue comprises a vessel enclosing a detonation chamber into which a detonatable mixture is introduced and then detonated using an igniter to form at least one shockwave and/or acoustic wave. A wave guide assembly having a converging geometry directs the wave to a tip of the wave guide assembly that is placed in contact with tissue to be treated by the wave. The wave guide assembly may include a wave focusing section surrounding the vessel, a flexible conduit connected to the wave focusing section and a needle connected to the conduit and sized for insertion into patient tissue to be treated. A cap connected to the end of the needle is formed from material permitting the wave or waves generated in the detonation chamber to pass therethrough to treat the patient tissue into which the needle is inserted.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: April 1, 2014
    Assignee: Medical Shockwaves Inc.
    Inventors: Yakov U. Koyfman, Gabriel Eidelman
  • Patent number: 8679070
    Abstract: A modular administration appliance including a reusable base unit and a replaceable cartridge detachably connected to the base unit and including a container for a substance and a rotatable transmission element, the base unit including a drive device by which a rotary movement is transmitted between the base unit and the cartridge, and a driving element displaceable in a rotary movement about a rotational axis by the drive device, wherein a rotation of the transmission element causes the ejection of at least a portion of the substance from the container. In some embodiments, the transmission element at least partially surrounds the drive device, and/or the drive element and the transmission element are detachably connectable to each other for transmitting the rotational movement.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: March 25, 2014
    Assignee: TecPharma Licensing AG
    Inventors: Jürg Clavadetscher, Edgar Hommann
  • Patent number: 8562589
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: October 22, 2013
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 8486002
    Abstract: Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 16, 2013
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Publication number: 20130178826
    Abstract: The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.
    Type: Application
    Filed: November 19, 2012
    Publication date: July 11, 2013
    Applicant: MINIPUMPS, LLC.
    Inventor: MINIPUMPS, LLC.
  • Patent number: 8430839
    Abstract: Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a first collimator fluidly connected with the gas source adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator has an inlet end and an outlet end. The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 30, 2013
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Patent number: 8388569
    Abstract: Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: March 5, 2013
    Assignee: Xerox Corporation
    Inventors: Scott Uhland, Eric Peeters
  • Patent number: 8352041
    Abstract: Remote controls, including a communication device, a button or other communication device actuator and a movable structure that allows actuation of the actuator in one position and prevents actuation of the actuator in another position to prevent inadvertent signal transmission.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: January 8, 2013
    Assignee: The Alfred E. Mann Foundation For Scientific Research
    Inventors: Stephen D. Das, Jose P. Bernardo, Daniel H. Villegas, Scott R. Gibson, Timothy John Payne, Scott LaVoy Conway, Joseph Wayne Vandegriff
  • Patent number: 8021357
    Abstract: A body-insertable apparatus including a balloon for storing a medical fluid in a capsule-like casing, and an injection needle including an elastic membrane. The body-insertable apparatus discharges the medical fluid due to contraction of the balloon, applies a discharge pressure of the medical fluid to the elastic membrane to expand the elastic membrane, and projects the injection needle from the casing due to the expansion of the elastic membrane. Further, the body-insertable apparatus has a channel forming unit for forming a channel connecting to the balloon and a channel connecting to the injection needle, and a communication adjusting mechanism. The communication adjusting mechanism adjusts a communicated state between the channels and, thereby controlling the start of medical-fluid discharge operation by the balloon.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: September 20, 2011
    Assignee: Olympus Corporation
    Inventors: Shinsuke Tanaka, Hironao Kawano, Hironobu Takizawa
  • Publication number: 20110202032
    Abstract: In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.
    Type: Application
    Filed: August 18, 2010
    Publication date: August 18, 2011
    Inventors: Jason Shih, Jeffrey Brennan, Fukang Jiang, Sean Caffey
  • Publication number: 20100298808
    Abstract: A delivery device (1) for administering an active substance to a subject transdermal? comprises a first plate member (7) having a plurality of first chambers (8) formed therein. Solid form structures (2) comprising the active substance and of conical shape having a pointed skin penetrating tip (5) are located in the first chambers (8). A second plate member (12) having a plurality of second chambers (16) comprising a driving substance (18) is secured to the first plate member (7) with a first membrane (20) of an expandable material sealably located between the respective first and second plate members (7,12). Expansion of the driving substance (18) in the second chambers (22) urges the first membrane (20) into the corresponding first chambers (8) for in turn urging the solid form structures (2) to penetrate through a second membrane (22) into the skin of the subject.
    Type: Application
    Filed: November 28, 2008
    Publication date: November 25, 2010
    Applicant: Janisys Limited
    Inventors: John O'Dea, Eoin Bambury
  • Patent number: 7753884
    Abstract: An apparatus is proposed for the dosed dispensing of a fluid, especially an infusion fluid, comprising a housing (1) with a fluid chamber and a pressure medium chamber (3) by which a flexible wall (4) of the fluid chamber can be pressurized from the outside with a pressure medium. In order to provide a re-useable infusion pump with especially simple means it is proposed that the housing (1) consists of two mutually detachably joined housing parts (6, 7), of which the one comprises the pressure medium chamber (3) and the other receives in an exchangeable manner the fluid chamber configured as a leak-proof infusion bag (2), and that the housing part (6) with the pressure medium chamber (3) is sealed by a membrane (5) against the housing part (7) receiving the infusion bag (2) and is connected to a gas pressure source (11).
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: July 13, 2010
    Assignee: PRO-MED Medizinische Produktions- und Handels-AG
    Inventor: Bernhard Gallnböck
  • Patent number: 7753879
    Abstract: A combination of a disposable, wearable, self-contained medicine dispensing device, a cylindrical medicine container 52 incorporating a piston and having an open distal end and a proximal end closed by a closure body 54 made of a material, preferably silicone, that can be perforated by a needle, and a catheter device 16 having adhesive means 26 for attaching the catheter device to the skin of a user of the combination, the dispensing device comprising a housing 34, 36 having a compartment for receiving the container and further a not shown piston rod for displacing the piston towards the closed proximal end and actuating means for displacing the piston rod, the catheter device comprising a sealing ring 56?for receiving the closure body, and the dispensing device and the catheter device comprising co-operating attachment means for attaching the dispensing device to the catheter device with the container received in the compartment with the piston rod abutting the piston and the closure body received in the sea
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: July 13, 2010
    Assignee: M2 Group Holdings, Inc.
    Inventor: Morten Mernoe
  • Patent number: 7591792
    Abstract: Tissue sensors house one or more sensor elements. Each element has a housing mounted substrate and a superstrate with a planar antenna between. A transitional periphery (TP) of a superstrate outer surface interconnects a base to a plateau. At least some of the TP has a generally smooth transition. Plural elements are spaced by the housing. Alternately, the superstrate TP is flat, the housing extends to the outer superstrate surface and a shield surrounds the element. The housing is flush with or recessed below the superstrate and defines a TP between the housing and superstrate. A method converts a reference signal to complex form; plots it in a complex plane as a reference point (RP); converts a measurement signal to complex form; plots it in the complex plane as a measurement point (MP); determine a complex distance between the MP and the RP; and compares complex distance to a threshold.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: September 22, 2009
    Assignee: Medrad, Inc.
    Inventor: Chad Edward Bouton
  • Patent number: 7108686
    Abstract: An implantable infusion device (10) includes a lightweight, inert housing (12) which contains an infusate (18) for administration to a patient, and an enclosed, gas-impermeable variable volume chamber (30) which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. A recharging fluid flow path (31) is provided adjacent to where the variable volume chamber is attached to the housing. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port (38) is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: September 19, 2006
    Assignee: Bard Access Systems, Inc.
    Inventors: Paul Burke, Kenneth A. Fine
  • Patent number: 6830560
    Abstract: A syringe comprises a barrel containing an internal cylindrical body containing a liquid and communicating with a delivery needle. The needle is covered before use by a removable sheath, and after the sheath is removed, the needle is concealed by a displaceable sleeve. In use the sleeve is pressed against the skin by applying pressure while holding the barrel. The sleeve is thereby retracted into the barrel allowing the needle to penetrate the skin. The movement of the sleeve also activates a gas generator which expels the liquid from the needle. When delivery is complete and the syringe is taken from the skin, a coil spring moves the sleeve back to the starting position again concealing the needle. The coil spring is torsionally biased before use and causes a rotational movement of the sleeve relative to the barrel when the sleeve moves into and out of the barrel. This rotational movement engages a locking mechanism which prevents further movement of the sleeve and thereby permanently conceals the needle.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: December 14, 2004
    Assignee: Elan Corporation PLC
    Inventors: Joseph Gross, Gilad Lavi, Izrail Tsals
  • Patent number: 6562004
    Abstract: A device for transdermal delivery of a composition includes a housing partitioned into a delivery chamber arranged to contain the composition and a detonation chamber mechanically coupled to the delivery chamber. The detonation chamber is intended to contain an energetic material producing an impulse transient in response to a detonating stimulus. The housing is coupled to an energy coupling element, or detonator, for communicating energy provided by an external energy source into the detonating stimulus in the detonation chamber. The detonator can detonate the energetic material by causing an electrical discharge or spark within the detonation chamber. The detonator can be a piezoelectric film in electrical communication with the energetic material.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: May 13, 2003
    Assignee: The Massachusetts General Hospital
    Inventors: Apostolos Doukas, Shun Kwan Lee, Thomas J. Flotte
  • Patent number: 6537245
    Abstract: A needleless syringe equipped with an initiating device comprising a triggering device and a pyrotechnic charge, wherein the triggering device contains a triggering member connected to a friction igniter that initiates the pyrotechnic charge by friction. An advantage of the invention is that the syringe produces very limited amounts of noise during operation.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: March 25, 2003
    Assignee: Crossject Company
    Inventors: Patrick Alexandre, Bernard Brououieres, Philippe Gautier
  • Patent number: 6458102
    Abstract: An external infusion device system for infusing a fluid into a patient, the system including a reusable infusion device housing, a gas power source and disposable reservoir. The disposable reservoir is insertable into the reusable infusion device housing to infuse the fluid into the patient. The gas power source is for generating a gas to expel the fluid from the fluid reservoir. The disposable reservoir includes a reservoir housing, a fluid reservoir, an outlet, a gas power source, an expansion chamber and a regulating valve assembly. The fluid reservoir is within the reservoir housing for containing the fluid to be infused into the patient. The outlet is in the reservoir housing and provides a path through which the fluid is expelled to be infused into the patient. The expansion chamber is disposed between the gas power source and the fluid reservoir to receive the gas from the gas power source. The expansion member expands into the fluid reservoir to expel the fluid from the fluid reservoir.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: October 1, 2002
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Alfred E. Mann, H. Lee Renger, Clyde Nason, Hiwa Nezhadian
  • Publication number: 20020072709
    Abstract: The invention relates to methods and devices for delivering medicament by jet injection to an injection site in a patient. The method includes inserting a needle into an insertion point, wherein the needle has a length of less than 5mm and is operatively associated with an orifice in a nozzle assembly in fluid communication with an ampule chamber containing the medicament. The needle extends less than about 5 mm from the nozzle assembly orifice when the medicament is expelled. Next, a force generating mechanism is activated, and a pressure wall member that is operatively associated with the force generating member moves in response to the activation of the force generating mechanism at a speed sufficient to jet inject the medicament from the ampule chamber through the orifice and needle under a pressure of less than about 4000 psi to deliver a substantial portion of the medicament through the needle and past the insertion point to the injection site.
    Type: Application
    Filed: January 31, 2002
    Publication date: June 13, 2002
    Applicant: ANTARES PHARMA, INC.
    Inventors: Peter L. Sadowski, David M. DeBoer, Claude L. Berman, Paul R. Lesch
  • Patent number: 6383165
    Abstract: A system for achieving a controlled low emission rate of small volumes of liquid solutions for pest and insect management and other applications. The system has a sealed liquid solution reservoir having an outlet port, a self-powered fluid delivery micropump, and a collector for receiving a liquid solution from the sealed liquid solution reservoir. The liquid solution reservoir has a small volume capacity in the range of 1-100 mL. The micropump is a fluid transfer device capable of delivering 1-1000 microliters/hour of liquid solution. The collector has a low emission rate in the range of 0.1-2000 mg/day. The micropump and the sealed liquid solution reservoir may be contained in a single assembly. Also the entire structure of the system may be located in a single container that may be attached to a support structure.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: May 7, 2002
    Inventors: Henri J. R. Maget, Robert J. Rosati
  • Patent number: 6099504
    Abstract: A syringe (10) comprises a barrel (11) containing an internal cylindrical body (12) containing a liquid (14) and communicating with a delivery needle (15). The needle (15) is covered before use by a removable sheath (16), and after the sheath (16) is removed, the needle (15) is concealed by a displaceable sleeve (20). In use the sleeve (20) is pressed against the skin by applying pressure while holding the barrel (11). The sleeve (20) is thereby retracted into the barrel (11) allowing the needle (15) to penetrate the skin. The movement of the sleeve (20) also activates a gas generator (17) which expels the liquid (14) from the needle (15). When delivery is complete and the syringe (10) is taken from the skin, a coil spring (22) moves the sleeve (20) back to the starting position again concealing the needle (15). The coil spring (22) is torsionally biased before use and causes a rotational movement of the sleeve (20) relative to the barrel (11) when the sleeve (20) moves into and out of the barrel (11).
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: August 8, 2000
    Assignee: Elan Corporation, plc
    Inventors: Joseph Gross, Gilad Lavi, Izrail Tsals
  • Patent number: 5947928
    Abstract: A drug delivery system includes a container having proximal and distal ends and a rapidly openable divider, replaceably disposed within the container to separate the container into a proximal chamber that is selectively gas impermeable and able to receive a pressurized gas and a distal chamber having an opening at a distal end thereof. A membrane is disposed between the opening in the distal chamber of the container and a biologic material, such as a patient's skin, treated with a medicament. In operation, rapid opening of the divider causes a shock wave to be generated and transmitted through the opening in the distal chamber to impinge on the membrane which transfers the shock wave to the biologic material. The system may further include a drug housing mountable in a fluid tight manner on the biologic material and an optional sealing element by which the fluid tight seal is created.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: September 7, 1999
    Assignee: Mile Creek Capital, LLC
    Inventor: David F. Muller
  • Patent number: 5938640
    Abstract: A fluid dispensing device is disclosed which has interfitting pump and reservoir modules, with unique releasable tight-fitting coupling mechanism incorporated into the opposed surfaces of the modules. Use of the two interfitting modules permits repeated re-use of the pump module containing the permanent electrical component, with a plurality of seriatim reservoir modules. Only the reservoir module needs to be sterilized. The battery power for the pump can come from a battery positioned within the pump module, which may be used with two or more reservoir modules, or within each reservoir module, which is used only with that single reservoir module. Pumping rate may be fixed or controllable. The coupling mechanism can be central of the device or off-center and is manually operable.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: August 17, 1999
    Assignee: M&R Consulting Services
    Inventors: Henri J. R. Maget, Donald H. Koenig
  • Patent number: 5891086
    Abstract: In a needle-less injector combining an actuator and a medicament cartridge, the actuator includes a housing with a forward portion to which the cartridge is connected. An impact member is mounted within the housing inward of the forward portion so as to be movable toward the forward portion, where it may strike components of the cartridge to effect expulsion of a dose of medicament. A chamber is provided within the housing and is pre-filled with a pressurized gas which is in communication with and exerts a constant force on the impact member, tending to urge it towards the forward portion.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: April 6, 1999
    Assignee: Weston Medical Limited
    Inventor: Terence Edward Weston
  • Patent number: 5871125
    Abstract: A liquid delivery pumping device for the delivery of liquids enterally or parenterally comprises a housing including a gas generating chamber, wherein a gas is generated intermittently when two reactants, such as the components of an effervescent couple, are caused to react, a pumping chamber for a reciprocating pumping unit operable by the gas and to which chamber the gas is conveyed once generated, the pumping unit forming part of a mechanism which receives and regulates the liquid to be delivered in response to the reciprocation of the pumping unit, and means for controlling the gas pressure within the pumping chamber to enable controlled reciprocation of the pumping unit. The device provides precisely controlled rates of liquid delivery to a patient irrespective of the viscosity of the liquid to be delivered.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: February 16, 1999
    Assignee: Elan Medical Technologies Limited
    Inventor: Joseph Gross
  • Patent number: 5785688
    Abstract: An apparatus (120) useful for, among other things, subcutaneous drug delivery includes a housing (124), a fluid reservoir (154) disposed within the housing for storing the fluid, a pump or pressurized chamber for pressurizing a driving gas and exerting a force on the fluid reservoir to expel the fluid reservoir's contents, and a needle (150) or absorbent pad fluidically communicating with the reservoir. The apparatus may further include a pump activation mechanism such as a button and an electrical circuit such that pushing the button activates a circuit and connects a battery (138) to a pump (126), and a pump control mechanism such as electrical circuitry to control the voltage gradient to a pump to control fluid delivery.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: July 28, 1998
    Assignee: Ceramatec, Inc.
    Inventors: Ashok V. Joshi, James O. Davis, Truman Wold, Giorgio di Palma
  • Patent number: 5741275
    Abstract: A device for controllably dispensing a liquid or viscous material comprises a chamber which is subdivided by a piston into a pressurized gas chamber and a mass chamber. The container includes electrochemical, tablet-shaped, completely enclosed diffusion electrodes, aqueous electrolytes, a gas development cell containing a counter-electrode, an adjusting rheostat and contacts held by a clamping device in the bottom of the container. A vibration-dampening funnel-shaped container cap encloses the top end of the container and is totally compliant and shock-proof. The piston includes a piston seal which has a sealing lip monolithically connected to the piston with a space for a film of grease. An alternative embodiment has exchangeable electric elements and a refilling device. Other alternative embodiments have a simplified compact design for small sizes or for infusion devices or are associated with piston sensors.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: April 21, 1998
    Inventor: Max Wyssmann
  • Patent number: 5738657
    Abstract: An ambulatory infusion and/or KVO (keep vein open) system (12, 18) has a gas-pressurized bladder arrangement (12) including a gas barrier associated therewith. The system includes a flexible bag of solution (13) inserted in a sleeve portion (36) of the bladder arrangement (12). Internal gas pressure which is developed within the bladder arrangement by a selectively initiated chemical reaction exerts a continuing pressure against the solution bag (13) to cause the solution to flow therefrom. A tubing set (18) of the system includes a flow restrictor (24) which is sized for minimal flow rates for indwelling catheter patency maintenance.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: April 14, 1998
    Assignee: Abbott Laboratories
    Inventors: Peter L. Bryant, Nicolaos A. Drivas, Rodney M. Mittag, John K. Moore, Edward S. Tripp, William L. Rudzena, John C. Williams
  • Patent number: 5704520
    Abstract: A liquid material dispenser, for use, for example, in dispensing liquid medicine over an extended period of time, which includes a housing (10) enclosing a reservoir (12) for storing the liquid to be dispensed and having an outlet (14) through which the liquid is dispensed, and a connecting passageway (16) between the reservoir and the outlet. Located in the passageway is a diaphragm (18), one side of which defines a pumping chamber (20) and the other side of which defines a pressure control chamber (22). The diaphragm (18) is cyclically displaceable through a pumping stroke for pumping liquid through the outlet (14) and a drawing stroke for drawing liquid from the reservoir (12). Also located in the passageway (16) are a pair of valves (30, 33) which serve, during the drawing stroke, to cause the diaphragm (18) to draw liquid from the reservoir (12) into the pumping chamber (20), and during the pumping stroke, to cause the diaphragm (18) to pump liquid from the pumping chamber (20) through the outlet (14).
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: January 6, 1998
    Assignee: Elan Medical Technologies, Limited
    Inventor: Joseph Gross
  • Patent number: 5700245
    Abstract: The present invention relates to apparatus and method for the controlled delivery of fluid. The apparatus comprises chemical reactants which combine to generate gas and create pressure to drive a fluid from a container. The reactants and the environment in which the reaction occurs are controlled, thereby causing the fluid to be delivered from the device at a predetermined flow rate.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: December 23, 1997
    Assignee: Winfield Medical
    Inventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
  • Patent number: 5571261
    Abstract: A liquid dispensing device and the method of dispensing liquid are disclosed. The device includes a hollow gas- and liquid-tight casing, a flexible gas- and liquid-tight membrane having multiple convolutions disposed across the casing interior and dividing the interior into a propellant chamber and a liquid chamber, an outlet port from the liquid chamber. A pressure relief valve, suitable for use with the device, allows gas to escape from the device when the gas pressure exceeds a predetermined level.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: November 5, 1996
    Assignee: River Medical, Inc
    Inventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
  • Patent number: 5558255
    Abstract: A liquid dispensing device and the method of dispensing liquid are disclosed. The device is uniquely suited to meet the requirements of hospitals and other institutions for long shelf life in inert condition and ready activation when needed. The device includes a hollow gas- and liquid-tight casing (preferably spherical or cylindrical), a flexible gas- and liquid-tight membrane disposed entirely across the casing interior dividing the interior into a propellant chamber and a liquid chamber; an outlet port from the liquid chamber; two mutually reactive chemicals in the propellant chamber but separated by a barrier; and a member to breach the barrier and permit the chemicals to come into contact; the two chemicals being reactive upon contact to form a propellant gas. The propellant gas thereupon expands against the membrane, moves the membrane to enlarge the propellant chamber, decrease the liquid chamber, and expel the contained liquid from the liquid chamber through the outlet port.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 24, 1996
    Assignee: River Medical, Inc.
    Inventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
  • Patent number: 5553741
    Abstract: A liquid dispensing device and the method of dispensing liquid are disclosed. The device is uniquely suited to meet the requirements of hospitals and other institutions for long shelf life in inert-condition and ready activation when needed. The device includes a hollow gas- and liquid-tight casing (preferably spherical or cylindrical), a flexible gas- and liquid-tight membrane disposed entirely across the casing interior dividing the interior into a propellant chamber and a liquid chamber; an outlet port from the liquid chamber; two mutually reactive chemicals in the propellant chamber but separated by a barrier; and a member to breach the barrier and permit the chemicals to come into contact; the two chemicals being reactive upon contact to form a propellant gas. The propellant gas thereupon expands against the membrane, moves the membrane to enlarge the propellant chamber, decrease the liquid chamber, and expel the contained liquid from the liquid chamber through the outlet port.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: September 10, 1996
    Assignee: River Medical, Inc.
    Inventors: Gregory E. Sancoff, Mark C. Doyle
  • Patent number: 5540665
    Abstract: The present invention provides a gas generating engine for driving a beneficial agent dispensing device. The engine comprising (a) a solid composition comprising an acidic compound or a basic compound, or a combination thereof, and (b) a means for maintaining substantially constant the surface area of the solid composition exposed to a reservoir fluid comprising water, or water and an acidic compound, or water and a basic compound, wherein in operation, the solid composition is exposed to the reservoir fluid which dissolves the solid composition and causes it to generate a gas, the gas being a driving fluid to dispense a beneficial agent. The present invention further provides a fluid driven dispensing device for delivering an agent into an environment of use, the device be driven by the gas generating engine.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: July 30, 1996
    Assignee: ALZA Corporation
    Inventors: Stanley A. Mercado, Mark M. McPhee, Avtar S. Nat, Su I. Yum, Scott A. Bura
  • Patent number: 5527288
    Abstract: An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: June 18, 1996
    Assignee: Elan Medical Technologies Limited
    Inventors: Joseph Gross, John G. Kelly
  • Patent number: 5425706
    Abstract: A dispensing device particularly useful for dispensing nutritional liquids includes an electrolytic cell having electrodes and an electrolyte capable of generating a gas upon the energization of the electrodes, which gas causes the dispensing of the liquid according to the rate of generation of the gas. The container for the liquid to be dispensed may be a disposable unit including the electrolytic cell, and a non-disposable electrical control circuit may be provided for controlling the rate of energization of the electrodes. The dispensing unit may also include an outer container adapted to receive a bag containing the liquid to be dispensed, the generated gas being applied between the outer container and the pliable bag.
    Type: Grant
    Filed: February 14, 1990
    Date of Patent: June 20, 1995
    Assignee: S. I. Scientific Innovations Ltd.
    Inventors: Jospeh Gross, Shlomo Zucker
  • Patent number: 5354264
    Abstract: A drug delivery device is described which utilizes gas pressure from free oxygen and hydrogen derived from the electrolysis of water at the electrodes in negatively charged polymeric hydrogels by electro-osmosis. The gas pressure forces the infusion of the drugs through appropriate means into the body. The rate of electrolysis which produces the oxygen and hydrogen is controlled by an electric current. Therefore the rate of drug delivery can be predetermined and precisely controlled. The current is activated and controlled by an electronic timer or a biomedical control system. The negatively charged hydrogel polymers have mechanical strength and rigidity and allow water to flow through the polymer network toward the cathode ensuring a continuous water supply to the electrodes inside the hydrogel system by electro-osmosis. The hydrogels may be recharged (reswollen) with water or simply replaced.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: October 11, 1994
    Assignee: Insutech, Inc.
    Inventors: You H. Bae, Ick C. Kwon
  • Patent number: 5279544
    Abstract: A transdermal drug delivery device includes a liquid reservoir for a liquid drug to be delivered, and a drug delivery body which includes a plurality of tubular elements extending through the body, each having an inlet end communicating with the liquid reservoir, and an outlet end engageable with the subject's skin to conduct the liquid drug directly to the subject's skin.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: January 18, 1994
    Assignee: Sil Medics Ltd.
    Inventors: Joseph Gross, Shlomo Zucker
  • Patent number: 5242406
    Abstract: A delivery device for delivering a liquid containing a drug includes a first diaphragm within a housing defining a first contractible-chamber on one side of the diaphragm for holding a supply of the liquid to be delivered, and a second contractible chamber on the opposite side of the diaphragm including an electrolytic cell capable of generating a gas according to the electrical current passed through the cell electrolyte. The device further includes a second diaphragm, a control valve, and a spring, for compensating the rate of delivery of the liquid for variations in ambient pressure and temperature.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: September 7, 1993
    Assignee: Sil Medics Ltd.
    Inventors: Joseph Gross, Shlomo Zucker
  • Patent number: 5224936
    Abstract: An automatic self-protecting hypodermic needle assembly comprising a hypodermic syringe having a housing, a moveable plunger in the housing, a medicant chamber formed between the housing and the plunger, and a hollow needle extending from the housing in communication with the medicant chamber. A needle guard assembly is attached to the syringe housing and includes a guard housing adjacent the needle, a protective cap removably attached to the guard housing and an aperture through which the needle extends. A propellant is located in the guard housing in communication with the protective cap. When activated by an activating element, the propellant expands from a liquid to a gas, applies a pressure to the protective cap, and drives the protective cap along the length of the needle until the cap extends beyond the tip of the needle and the needle tip becomes embedded in the protective cap.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: July 6, 1993
    Inventor: Brian Gallagher
  • Patent number: 5090963
    Abstract: A liquid material dispenser includes a rigid housing having a flexible partition defining first and second compartments on opposite sides of the partition, and an electrolytic cell in the first compartment capable of generating a gas when energized by a source of electric current in order to expand the first compartment and thereby to contract the second compartment. The second compartment contains the liquid material which is dispensed via a discharge opening in accordance with the rate of generation of the gas.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: February 25, 1992
    Assignee: Product Development (Z.G.S.) Ltd.
    Inventors: Joseph Gross, Shlomo Zucker
  • Patent number: 5062834
    Abstract: A device for dispensing a liquid, particularly a medicament, at a predetermined rate, includes a container including a displaceable partition to define a first expansible-contractible chamber on one side for receiving the liquid to be dispensed, and a second expansible-contractible chamber on the opposite side for receiving an electrolytic cell. The electrolytic cell has electrodes and an electrolyte capable of generating, upon the energization of the electrodes, a gas under pressure to thereby displace the displaceable partition and to force the liquid out from the first chamber in accordance with the rate of energization of the electrodes. The displaceable partition includes a piston assembly having a pair of pistons spaced apart by a connecting stem, the container being formed with a vent opening in the space between the pistons to prevent accidental mixing of the gas with the liquid to be dispensed.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: November 5, 1991
    Assignee: Product Development (S.G.Z.) Ltd
    Inventors: Joseph Gross, Shlomo Zucker
  • Patent number: 4969874
    Abstract: An insert head (102) is tightly inserted in the rearward end of a commercially available ampoule (101) equipped with a plunger (100). A galvanic, gas-generating cell is arranged in the insert head (102). The plunger (100) is driven forward by the gas generated by this cell. A throttle device (103) constituted by a capillary tube is connected to the Luer's syringe (109) of the ampoule (101), the infusion fluid driven out by the plunger (100) flowing through this throttle means into a catheter (104).
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: November 13, 1990
    Assignee: Disetronic AG
    Inventors: Peter Michel, Hans Muller
  • Patent number: 4969873
    Abstract: Septum for implantable devices for dispensing active substances, for example medicaments, to the body of the patient. The septum is inserted as a cover of a medicament chamber into the associated opening by means of one or more clamping members, the septum (22; 36; 10) being formed annularly with part (32) of the apparatus wall disposed within the septum and connected fixedly to the remaining housing (31).
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: November 13, 1990
    Assignee: Annemarie Schlogl Gesellschaft m.b.H. & Co., KG
    Inventors: Bernd Steinbach, Leopold Schlogl
  • Patent number: 4902278
    Abstract: A prime mover module used in a fluid delivery micropump, especially for pharmaceutical purposes, transports an electrochemically active material, such as oxygen, at a steady rate across an ion exchange cell to apply external pressure to a collapsible reservoir and expel fluid therefrom. An air-actuated battery, such as a zinc-air battery, which is located in the module in a fixed closed circuit with the cell and which shares one of its electrodes with the cell, is activated by peeling off an adhesive tape covering air inlet ports to thereby establish a voltage gradient acrosss the cell and control the rate at which fluid is expelled from the reservoir in accordance with the value of a resistor in the cell/battery circuit. The reservoir is filled or refilled by inserting a vented needle into an air bleed port while discharging a fluid-filled syringe inserted into a fluid injection port.
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: February 20, 1990
    Assignee: IVAC Corporation
    Inventors: Henri J. R. Maget, Paul K. Krejci