Having Plural Material Reservoirs Patents (Class 604/191)
  • Patent number: 10842467
    Abstract: Needle-less extraction of a biospecimen from tissue having a number of tissue layers including an epidermis layer includes creating a first port through a target surface and into an underlying one of the tissue layers, creating a second port through the target surface and into the underlying one of tissue layers, providing an injectate through the first port to the underlying one of the tissue layers underlying the epidermis layer, and extracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 24, 2020
    Assignee: Portal Instruments, Inc.
    Inventor: Andrew Coats
  • Patent number: 10765604
    Abstract: Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 8, 2020
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Igor Denenburg, Amir Lev, Uri David
  • Patent number: 10737033
    Abstract: Syringe systems including barrels having lubricated portions and non-lubricated portions are provided. The non-lubricated portions may be configured to be loaded with injectable materials, such as embolic agents. The injectable materials may comprise polyvinyl alcohol. Also provided are methods of lubricating portions of barrels of syringe systems with lubricants including silicone or silicone-free lubricants.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 11, 2020
    Assignee: Merit Medical Systems, Inc.
    Inventors: David Butts, Richard Jenkins, Gregory R. McArthur
  • Patent number: 10682395
    Abstract: The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: June 16, 2020
    Assignee: Ascendis Pharma Endocrinology Division A/S
    Inventors: Grethe Nørskov Rasmussen, Susanne Kindermann, Harald Rau, Thomas Wegge
  • Patent number: 10675453
    Abstract: A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: June 9, 2020
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10675438
    Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: June 9, 2020
    Assignee: ALCYONE LIFESCIENCES, INC.
    Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
  • Patent number: 10668260
    Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 2, 2020
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Yoshihiro Omachi, Yasuhiro Hiraishi, Masami Kusaka, Shigehiro Asano, Masao Nagao
  • Patent number: 10668247
    Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: June 2, 2020
    Assignee: ALCYONE LIFESCIENCES, INC.
    Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
  • Patent number: 10603434
    Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: March 31, 2020
    Assignee: West Pharmaceutical Services, Inc.
    Inventor: Hubert Jansen
  • Patent number: 10589078
    Abstract: Methods for fabricating metallic microneedles are disclosed. One method comprises providing a mold pillar; forming an apertured electrically-conductive layer over the mold pillar; and depositing a metal layer over the electrically-conductive layer to provide an apertured microneedle. Another method comprises providing a mold pillar; depositing a first metal layer over the mold pillar to provide a first microneedle; removing the first microneedle from the mold pillar; and depositing a second metal layer over the mold pillar to provide a second microneedle.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: March 17, 2020
    Assignee: Microdermics Inc.
    Inventors: Boris Stoeber, Iman Mansoor, Urs Otto Häfeli
  • Patent number: 10549045
    Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: February 4, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Axel Forstreuter
  • Patent number: 10525205
    Abstract: A dispense mechanism for a drug delivery device for the delivery of a primary medicament in a primary cartridge and a secondary medicament in a secondary cartridge includes a primary drive member and a secondary drive member serve for driving a primary and a secondary lead screw. The primary drive member and the secondary drive member are configured to rotate during dose dispense. A coupling member serves for rotationally coupling the primary drive member to the secondary drive member and moves from a first position in which the primary drive member is rotationally decoupled from the secondary drive member into a second position in which the primary drive member is rotationally coupled to the secondary drive member during dose dispense. Rotation of the primary drive member moves the coupling member from the first position into the second position.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: January 7, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Matthew Jones, Samuel Steel, Neal Alexander Blundred, Joseph Butler, Robert Veasey, David Aubrey Plumptre
  • Patent number: 10518958
    Abstract: A cartridge fillable or filled with a dispensable medium for dispensing the medium by movement of a piston receivable or received in the cartridge has a sliding surface for the piston to slide along during the movement of the piston. The sliding surface has a microstructure for reducing the friction between the piston and the sliding surface.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: December 31, 2019
    Assignee: SULZER MIXPAC AG
    Inventors: Florian Senn, Victor Clemens
  • Patent number: 10493199
    Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: December 3, 2019
    Assignee: VALERITAS, INC.
    Inventors: Robert R. Gonnelli, Steven F. Levesque, Ronald V. Nardi
  • Patent number: 10493206
    Abstract: A dental anesthetic buffer assembly advantageously attaches to carpule-loaded syringe in the same manner as a standard disposable needle. The dental anesthetic buffer assembly, however, incorporates a pH-raising buffer that advantageously dissolves into and mixes with the carpule anesthetic during injection, in lieu of pre-mixing the buffer and anesthetic prior to injection.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: December 3, 2019
    Inventor: Yasser Sadek
  • Patent number: 10449295
    Abstract: A syringe assembly includes a first syringe having a first syringe outer cylinder filled with a first liquid, and a first gasket; a second syringe having a second syringe outer cylinder filled with a second liquid, and a second gasket; and a pusher assembly which performs a pushing operation of collectively moving the first and second gaskets. The pusher assembly includes a first pusher having a distal portion connected to the first gasket; a second pusher branching from the first pusher, extending distally, having a distal portion connected to the second gasket; and an operation section which is provided on a proximal-side extension line of the first pusher and is operated for the pushing operation.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 22, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kenji Yokoyama, Kunio Fukui
  • Patent number: 10398851
    Abstract: A method of using a medicine injection device including a syringe filled with a medicine; a needle tube having a needle tip for puncturing the skin; a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube; and an absorption part that is disposed in the skin contact portion of the needle hub. The method includes removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the skin contact portion; the absorption part absorbing the spilled medicine staying in the skin contact portion; positioning the skin contact portion adjacent the skin; puncturing the skin with the needle tip; and injecting medicine from the needle tip into the skin.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: September 3, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yoichiro Iwase, Junichi Ogawa, Kouichi Tachikawa
  • Patent number: 10391257
    Abstract: An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: August 27, 2019
    Assignee: 410 Medical, Inc.
    Inventors: Mark D. Piehl, Galen C. Robertson, John Tyler Willis Hagler, Robert W. Titkemeyer, Frederic C. Feiler, Jr.
  • Patent number: 10327990
    Abstract: A container for storing and mixing two components is provided. The container includes a body, a first plug, and a second plug. The body has a first end, a second end, and a bypass with a length L disposed between the first and second ends. The first and second plugs are slidably disposed in the body and define a first compartment. A second compartment is in the body between the second plug and the second end. The second plug has a first edge, a second edge, and a primary conduit extending therein, a plurality of secondary conduits extending from the primary conduit through the second plug. The primary conduit has a first opening. A distance D extends longitudinally from the first edge to the second edge and a distance E extends longitudinally from the first edge to the first opening. D?L and E<L.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 25, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Marc A. Egeland, Chin-Yee Ng, Jo A. Etter, Ravi Kolakaluri
  • Patent number: 10322235
    Abstract: A plurality of embodiments of mixing syringes are provided. Inventive key to all of the embodiments is a piston valve which divides a barrel to create a pair of chambers in which matter and liquid can be disparately and securely disposed before mixing. Each disclosed piston valve is actuated by force on an associated plunger rod which produces pressure within an associated syringe resulting in a change of the valve state from closed to open. In addition, each such valve comprises check valve action which is permissive to only distal flow through the syringe. Embodiments for both a basic mixing syringe and a mixing syringe with flush are disclosed. Considerations and methods for chamber filling without valve actuation are provided. A mixing syringe system with flush system utilizing a dual chamber syringe having a male luer fitting and a separate diluent containing vessel having a female luer fitting is also disclosed.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: June 18, 2019
    Assignee: THORNE CONSULTING & INTELLECTUAL PROPERTY, LLC
    Inventors: Gale Harrison Thorne, Jr., Kendall Patterick Thorne, Gale Harrison Thorne, Sr.
  • Patent number: 10300203
    Abstract: A priming mechanism for operating an automatic injection apparatus to ensure medication contents are properly delivered prior to a needled syringe of the apparatus being injected. The priming mechanism includes a push rod to move plunger(s) within the syringe; a releasable support including bendable supporting arms, which limiting motion of the syringe relative to an upper housing body before and during priming; and a recess element inside the lower housing body to release said bendable arm to allow motion of the syringe relative to the upper housing body in distal direction after priming. In one form, the priming mechanism is used for removing air bubble before injection to ensure delivering correct dose. In another form, the priming mechanism is used to mix different contents in a dual chamber syringe before injection.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: May 28, 2019
    Inventor: Min Wei
  • Patent number: 10293115
    Abstract: An injector for administering a first and a second liquid or pasty substance, in particular a drug, comprises an outer injector body in which an inner injector body is longitudinally displaceably guided in which a plunger is longitudinally displaceably guided. To improve such an injector, the inner injector body has a cuff which sealingly contacts the inner wall of the outer injector body and which can be flowed around by the second liquid or pasty substance when it is in the end position in the outer injector body.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: May 21, 2019
    Assignee: elm-plastic GmbH
    Inventors: Birgit Lonien, Sascha Moehs
  • Patent number: 10226581
    Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: March 12, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Bjorn Wilden, Wolfgang Pelzer
  • Patent number: 10179187
    Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: January 15, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Jafar Golzarian, Lihui Weng
  • Patent number: 10172660
    Abstract: An assembly includes a dispensing syringe device configured to receive an amount of biomaterial and to dispense the biomaterial. The dispensing syringe device includes a syringe barrel for receiving the biomaterial, a discharge outlet for dispensing the biomaterial from the syringe barrel, and a plunger received in the syringe barrel. The plunger has a plunger body and a plunger passageway extending therethrough configured to receive a stylet. The assembly further includes a cannulus device configured to be coupled with the dispensing syringe device, to receive biomaterial from the dispensing syringe device, and to dispense the biomaterial. The cannulus device includes a cannulus passageway configured to receive the biomaterial and a dispensing opening configured for dispensing the biomaterial.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: January 8, 2019
    Assignee: Nordson Corporation
    Inventors: Huadong Lou, Bradley D. Robb, Zachary Rzeszutek, Mark Stevenson
  • Patent number: 10136893
    Abstract: An endovascular anastomotic connector and method of using the same. The endovascular anastomotic connector includes a vascular conduit and a supply conduit. The vascular conduit has proximal and distal ends that reside within a vascular structure. The supply conduit extends at an angle from the vascular conduit. The proximal end of the supply conduit is configured to be attached to an auxiliary device.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 27, 2018
    Assignee: CircuLite, Inc.
    Inventor: Robert C. Farnan
  • Patent number: 10130768
    Abstract: A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: November 20, 2018
    Assignee: UNL Holdings LLC
    Inventors: Peter J. Dungar, Molly M. Weaver, Philip A. Weaver, Katlin M. Lumme, Robert E. Johannesson
  • Patent number: 10124340
    Abstract: The present disclosure relates to a reagent storage device and a bio-reaction apparatus including the same. Provided is a reagent storage device connected to a biochip to provide reagents into the biochip. The reagent storage device includes a storage container having a tube shape of which one end is opened, and the other end opposite to the one end is closed and a plurality of diaphragms provided in the storage container and installed to be closely attached to an inner wall of the storage container. Here, the diaphragms are spaced apart from each other in one direction in which the one end and the other end are disposed opposite to each other, and each of the diaphragms includes a through-hole passing therethrough.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 13, 2018
    Assignee: Electronics and Telecommunications Research Institute
    Inventor: Kwang Hyo Chung
  • Patent number: 10117764
    Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: November 6, 2018
    Assignee: CARDINAL HEALTH SWITZERLAND 515 GMBH
    Inventors: Salvatore G. Caldarise, Carl J. Evens
  • Patent number: 10105491
    Abstract: A collapsible syringe assembly for a fluid delivery system is a multi-component device that includes a cylindrical pressure jacket and a collapsible syringe that is received within the pressure jacket. The collapsible syringe includes a cap member and a compressible or deformable sidewall member. The collapsible syringe in one embodiment is adapted to be secured to the pressure jacket by the cap member. The cap member is formed with a discharge port, which may be formed as conventional luer fitting. The discharge port is disposed coaxially within an annular wall on the outward facing side of the cap member and may be recessed within the annular wall.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: October 23, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Eugene A. Gelblum, Edward J. Rhinehart, Barry L. Tucker, Mark Trocki, John Puskar-Pasewicz, Matthew Beale, Matthew Sass
  • Patent number: 10099015
    Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: October 16, 2018
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Michael Pfoser, Björn Wilden
  • Patent number: 10092695
    Abstract: The presently disclosed subject matter relates to an addition to a medical applicator in general and in particular to an addition to a medical applicator for applying on a surface a curable liquid substance having multi components.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 9, 2018
    Assignees: Ethicon, Inc., Omrix Biopharmaceuticals Ltd.
    Inventors: Erez Ilan, Kfir Regev, Yotam Gurman, Robert J. Tannhauser
  • Patent number: 10085729
    Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 2, 2018
    Assignee: Ethicon, Inc.
    Inventors: Dennis D. Jamiolkowski, An-Min Jason Sung, Leo B. Kriksunov
  • Patent number: 10076611
    Abstract: Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medical injector and an electronic circuit system. The medical injector includes a housing, a medicament container, and a medicament delivery member. The housing defines a first region and a second region. The first region includes the medicament container and is physically isolated from the second region. The electronic circuit system is configured to be disposed within the second region defined by the housing. The electronic circuit system is configured to output an electronic output associated with a use of the medical injector.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 18, 2018
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards, Mark J. Licata, Paul F. Meyers, David A. Weinzierl
  • Patent number: 10039880
    Abstract: A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: August 7, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Marc Holtwick, Ilona Eggert, James Alexander Davies, Simon Lewis Bilton, David Moore, Steven Wimpenny, Christopher Nigel Langley, Jeffrey Zajac
  • Patent number: 10004526
    Abstract: An ultrasonic surgical system is provided. The ultrasonic surgical system includes an ultrasonic instrument that is configured to ultrasonically treat tissue. An ultrasonic generator configured to provide ultrasonic energy to the ultrasonic instrument provides an indication to a user that a specific outcome has been achieved. The indication is output via a device selected from an audio activation end-tone device, a visual activation end-tone device or a tactile activation end-tone device. The ultrasonic generator includes an end-tone outcome indicator module that includes memory having one or more data look up tables that is accessible by a microprocessor associated with the ultrasonic generator.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: June 26, 2018
    Assignee: COVIDIEN LP
    Inventors: Sean T. Dycus, Melissa J. Muszala
  • Patent number: 9999734
    Abstract: In an injection device a rotary indicator element (20) indexes angularly between a pre-firing position to an injection complete position to create a visual and audible/tactile signal as the drive plunger (28) arrives at or near its fired position. The indicator element (20) has a saw tooth profile which co-operates with respective abutments (34, 40) on the plunger and a housing part of the device to control and energize indicator movement.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: June 19, 2018
    Assignee: OWEN MUMFORD LIMITED
    Inventor: Toby Cowe
  • Patent number: 9993298
    Abstract: The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 12, 2018
    Assignees: Baxter International Inc., Baxter Healthcare, S.A.
    Inventors: Alexander Petter-Puchner, Heinz Redl
  • Patent number: 9987432
    Abstract: A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 5, 2018
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu
  • Patent number: 9950114
    Abstract: A dual-chamber syringe system is disclosed. Critical system oriented elements are disclosed, including plunger valve designs for accurate measurement and true, non-canting displacement; tamper and inadvertent valve actuation indicators, as well as, valve status indicators; anti-reflux construction; novel indicia patterns for dual-chamber syringe operation; structure and method for quality assurance that no gas can be delivered from a proximal chamber of the dual-chamber syringe and a kit for single step dose transfer. In addition, a tapered fitting valve is disclosed. The tapered fitting valve comprises a single molded incompressible, but supple part and a skeletal support whereby the tapered fitting valve is opened by insertion into a tapered fitting. The preferred embodiment of an actuator portion of the valve is elliptical in shape.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: April 24, 2018
    Assignee: THORNE CONSULTING FOR INTERNATIONAL PROPERTY, LLC
    Inventors: Gale Harrison Thorne, Jr., Kendall Patterick Thorne, Gale Harrison Thorne
  • Patent number: 9925118
    Abstract: The invention is related to a manifold comprising at least two valve receptacles, further comprising a fluid groove arrangement comprising at least two fluid grooves, wherein a first fluid groove of the at least two fluid grooves has a starting point near a first valve receptacle of the at least two valve receptacles and an end point near a second valve receptacle of the at least two valve receptacles and wherein a second fluid groove of the at least two fluid grooves has a starting point near a second valve receptacle of the at least two valve receptacles. The invention is further related to an apparatus comprising a manifold of the aforementioned kind and further comprising an inner body of a dispense interface.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: March 27, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Marc Holtwick, James Alexander Davies, Simon Lewis Bilton, David Moore, Steven Wimpenny, Christopher Nigel Langley
  • Patent number: 9919137
    Abstract: An inflation system having two pressure vessels integrated into a balloon catheter. A pressurized chamber and a vacuum chamber are integrally attached to proximal end of the balloon catheter and activated by a common valve or switch. Pressure or vacuum is selectively transmitted to the balloon depending on the valve/switch position. The working fluid may be air, or a combination of air and saline with an intermediate piston/cylinder assembly. The balloon catheter may be a part of a heart valve delivery system with a balloon-expandable heart valve crimped onto the balloon.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: March 20, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Harvey H. Chen, Andrew Phung, Thomas Chien, Da-Yu Chang
  • Patent number: 9889260
    Abstract: The invention relates to a dispense interface comprising a body comprising at least a first channel structure and a second channel structure, wherein each of the at least two channel structures comprises at least a first inlet channel comprising a first inlet opening and a second inlet channel comprising a second inlet opening, wherein each of the at least two inlet openings of one channel structure is configured for fluid communication with a respective reservoir of at least two reservoirs and wherein at least one connecting channel configured for a fluid communication between at least one outlet opening and one of the at least two channel structures is provided.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: February 13, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Frederic Laugere, Cristian Popa, Ben Impey, Andrew MacLeod
  • Patent number: 9878105
    Abstract: The invention provides a dispense interface for an ejection device comprising a first part and a second part, at least a first opening, a second opening and a third opening, a fluidic channel and a connection element for each of the openings, wherein the first part is joined to said second part to form at least a part of said fluidic channel connecting said openings with each other and wherein each connection element is configured to accept a needle assembly for a fluid tight connection with said corresponding opening in order to reduce the complexity and provide an easy usage of the dispense interface and at the same time overcome the problems of material compatibility and cross contamination. The invention also relates to a system comprising a dispense interface according to the invention and a needle assembly for each opening. Furthermore, the invention relates to a method for preparing a dispense interface according to the invention.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: January 30, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Ilona Eggert, Frederic Laugere, Cristian Popa, Ben Impey, Andrew Macleod
  • Patent number: 9872962
    Abstract: Provided are mixing syringes having two chambers defined by a pair of pistons located one above the other inside the syringe. Mixing of components separately stored in each of the two chambers occurs when a reversible valve occluding a bore in the distal piston near the discharge end is unseated by removing the retention sleeve and pressing the knob, and the proximal piston nearer the top of the syringe is moved axially toward the distal piston. Further movement of the proximal piston causes it to abut the distal piston resulting in the two pistons acting as one to dispel the now mixed components through the discharge end. Methods are provided for using the syringes for storage and mixing components; discharging the components from the syringe such as by administering the components to a patient in need thereof through a needle when the components are a medicament product.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: January 23, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Christopher J. Granelli
  • Patent number: 9821118
    Abstract: An automatic mixing device, an actuating device removably mounted to the automatic mixing device and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that initiates spring decompression to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 21, 2017
    Assignee: UNL Holdings LLC
    Inventors: Katlin M. Adlon, Philip A. Weaver, Peter J. Dungar
  • Patent number: 9814841
    Abstract: A medical device having a frontal attachment and a connector housing having or attachable to an associated medical apparatus, the frontal attachment slidably engaging the connector housing and having a forwardly projecting, rearwardly biased needle and a needle retraction assembly, and the connector housing having a needle retraction cavity laterally offset from the needle in a first position, the needle retraction cavity being selectively movable relative to the frontal attachment following use to reposition the needle retraction cavity into alignment with the needle to permit retraction.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 14, 2017
    Assignee: Retractable Technologies, Inc.
    Inventors: Thomas J Shaw, Mark Small, Ni Zhu
  • Patent number: 9731085
    Abstract: A cartridge assembly (200) having a shared fastening features for use with a drug delivery device (202). The cartridge assembly includes a cartridge holder (204), a drug cartridge (206), and a connector (208). The connector may be attached to the drug cartridge. The cartridge assembly further includes a fastening means (210, 212) for fastening to a drug delivery device, and this fastening means is shared between the cartridge holder and the cartridge or between the cartridge holder and the connector. The drug delivery device may be a reusable drug delivery device or a disposable drug delivery device.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: August 15, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Thomas Frederick Osman, Richard James Vincent Avery, Joseph Butler, Aled Meredydd James
  • Patent number: 9687599
    Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: June 27, 2017
    Assignee: VALERITAS, INC.
    Inventors: Robert R. Gonnelli, Steven F. Levesque, Ronald V. Nardi
  • Patent number: 9669165
    Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 6, 2017
    Assignee: AbbVie Inc.
    Inventors: Sean E. Mackey, Ji Zhou, Martin J. Gibler, Dennis Y. Lee