Abstract: A mixing device configured to hold two containers, each having a separate medicament component disposed therein. A fluidic channel is provided that upon creating fluidic communication with each container once seals about each container are opened. Then a transfer mechanism can transfer the medicament components from one container to the other container until ready to be delivered or transferred through the fluidic channel through a delivery assembly.

Abstract: A system and method for treating a necrotic tooth in a root canal and includes using a dual function double barrel reciprocating syringe in conjunction with a dual channel needle to provide both an irrigant for irrigation and aspiration of the irrigant and organic debris within the necrotic tooth. Once optimally positioned and secured in place by a rubber seal, root canal of the tooth can be treated through irrigation and aspiration of the dual channel needle.

Abstract: One aspect relates to a device for mixing two liquids including a tube having an open end, a main line connected to the tube in a liquid-permeable manner, a rubber-elastic body delimiting a line wall of the main line, at least one secondary line in the rubber-elastic body, wherein the at least one secondary line extends from at least one secondary opening up to the main line and opens via at least one mouth into the main line, a main connection for introducing a first liquid into the main line, at least one feed line for introducing a second liquid into the at least one secondary line, which is connected to the at least one secondary opening in a liquid-permeable manner. The at least one secondary line is closed in the rubber-elastic body without the action of a force and is hydraulically openable by a pressure being exerted on a second liquid fed to the at least one secondary line by an elastic deformation of the at least one rubber-elastic body.

Abstract: A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position.

Abstract: The invention relates to a syringe-connector device comprising, in particular, a hollow plunger including an open inner channel, which plunger can move inside a reservoir, said reservoir being open at one end in a distal connection, for the separate administration of controlled quantities of at least two products in a single injection.

Abstract: Disclosed herein is a fluid dispenser comprising a barrel defining a longitudinal axis terminating at a first fluid delivery end region; a body movable along the barrel relative to the first fluid delivery end region, the body including a needle carrier, a plunger and a capsule carrier therebetween, a latch interface between the body and the barrel and responsive to a release force therebetween caused by compressive engagement of the barrel at a fluid delivery site on a patient, to enable travel of the plunger and capsule carrier toward the needle carrier, to a dispensing configuration in which an upstream end of the needle pierces the capsule and projects form the first fluid delivery end region to deliver a fluid to the fluid delivery site.

Abstract: Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: A liquid handling system and method, e.g., for testing blood samples. The system comprises a cartridge, and a transfer device couplable to a liquid reservoir. The cartridge comprises compartments with an inlet, closed by a seal, and an outlet, closed by a gas-permeable liquid-tight filter. Keying portions define a relative position and orientation of the cartridge and the transfer device. Penetrating elements of the transfer device penetrate the seal of each compartment, the penetrating elements having lumina for fluidly connecting the reservoir and each compartment cavity of the cartridge.

Abstract: A sealant syringe assembly includes a first syringe including a plurality of chambers and discharging a first solution which is a mixture of a buffer solution and compound powder; a reaction solution syringe including at least one chamber and discharging a reaction solution capable of reacting with the first solution; and a connector for connecting the first syringe and the reaction solution syringe to mix and discharge the first solution and the reaction solution. The first syringe includes three packing members provided inside the first syringe; a passage provided in the inner circumferential surface of the first syringe; and a plunger for providing a pressure to one of the packing members.

Abstract: Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.

Abstract: An adapter manifold having an adapter body and a syringe applicator, wherein the adapter body has substantially parallel inlet ports and substantially parallel exit ports, the inlet ports spaced an axial distance apart which is different from an axial distance between the exit ports, to accommodate the syringe applicator which has multiple substantially parallel syringes, and substantially parallel syringe connectors in fluid communication with the inlet ports having Luer-type receivers on proximal ends thereof, wherein the syringe connectors are biased toward a proximal end of the adapter body.

Abstract: A double barreled injector assembly for performing multiple sequential vaccinations includes a pair of barrels, each of which is engaged by a first terminus thereof to a bar and extends from a lower face thereof. A respective agent can be positioned in each barrel. Each barrel has an orifice positioned in a second terminus thereof. A pair of actuators is engaged to an upper face of the bar. Each actuator is operationally engaged to a respective barrel and can be actuated by action of a hand of a user to dispense an associated agent through the orifice of the respective barrel into an animal. The injector assembly allows the user to perform multiple sequential vaccinations with two different vaccines and will be useful in vaccination of herds or flocks of livestock, such as poultry, cattle, and the like.

Abstract: An injector for delivering a therapeutic product may include a base having a flexible surface that conforms to various body contours of a patient and defines one or more an injection chambers. The injector may have a height that is substantially less than its width, thereby defining a low profile, which provides a larger more stable base that can pinch or stretch the skin in a controlled manner. The larger base can also accommodate larger volumes via multiple injection chambers and/or large combined primary containers.

Abstract: A device for aseptic delivery of biological material from a vial includes a tubular barrel, a filter assembly, and a dispersion funnel assembly. The tubular barrel includes a receiving end to accept at least a portion of the vial within the tubular barrel, and a dispensing end opposite the receiving end. The filter assembly is fluidly connected to the dispensing end of the tubular barrel. The dispersion funnel assembly is configured to connect to the vial, and to be disposed at least partially within the tubular barrel. The dispersion funnel assembly has an open configuration to disperse the biological material from the vial into the tubular barrel between the dispersion funnel assembly and the filter assembly, and a closed configuration to force the dispersed biological material through the filter assembly when the dispersion funnel assembly is moved toward the dispensing end of the tubular barrel.

Abstract: An injection apparatus for sequentially injecting a patient with at least two medicaments may include a hand-held unit comprising a grip for being held by an operator, a single needle, a base unit coupled to the hand-held unit via at least one connecting tube, at least two containers for holding medicaments removably coupled to the base unit, and at least one pump. The at least one connecting tube can be flexible enough to enable easy maneuvering of the hand-held unit and rigid enough to prevent widening of the tube due to inner pressure when medicaments pass from the containers to the hand-held unit. The injection apparatus can be used to administer the at least two medicaments sequentially at different injection points.

Abstract: The present invention provides a drug delivery device (2, 3; 102) for sequential administration of substances, comprising a first variable volume reservoir (40a; 140a) holding a first substance and comprising a first outlet (41 a, 141 a) and a first displaceable wall (43a; 143a), a second variable volume reservoir (40b; 140b) holding a second substance and comprising a second outlet (41 b; 141 b) and a second displaceable wall (43b; 143b), a first wall actuation structure (65a, 70a, 75a, 77a; 177a) activatable to move the first displaceable wall (43a; 143a) and thereby expel a dose of the first substance through the first outlet (41 a; 141 a), a second wall actuation structure (65b, 70b, 75b, 77b; 177b) activatable to move the second displaceable wall (43b; 143b) and thereby expel a dose of the second substance through the second outlet (41 b; 141 b), and a drive structure (90; 190) for activating the first wall actuation structure (65a, 70a, 75a, 77a; 177a) and the second wall actuation structure (65b, 70b,

Abstract: A syringe manifold (300) for a fluid injector assembly includes a middle body member (304) defining an upper cavity (308) and a lower cavity (309), the middle body member defining at least one fluid path in an upper surface of the middle body member and at least one fluid path in a lower surface of the middle body member, the middle body member defining at least two ports extending through the middle body member, the middle body member comprising an outlet (302) for connection of the syringe manifold to at least one fluid delivery device; a lower body member (303) received within the lower cavity of the middle body member, the lower body member comprising at least one connector for connection of the lower body member to a syringe assembly (700); and an upper body member (305) received within the upper cavity of the middle body member.

Abstract: Disclosed is a centrifugable syringe and syringe components for use in blood fractionation. Also disclosed is a method of blood fractionation using the syringe. The syringe comprises a substantially transparent barrel, a substantially transparent, elongated delineation neck, a plunger for drawing blood into and expelling blood from the barrel, and an adapter attached to the neck for enabling releasable connection of a selected device over an inlet/outlet opening in the neck. The delineation neck extends away from a distal end of the barrel. The barrel and the neck have respective axial bores in fluid flow communication with each other, the cross sectional area of the bore in the delineation neck being substantially less than the cross sectional area of the bore in the barrel.

Abstract: A medicament delivery device includes a main injection needle for injecting a medicament into the body of a patient. The medicament delivery device includes a pain reduction device for releasing a pain reduction agent into the body of the patient prior the medicament injection. The pain reduction device includes an array of microneedles.

Abstract: Multi-dose dispenser comprising: a product reservoir (14), on the X-axis, opening at a distal end through an outlet orifice and comprising a barrel (24); a piston (20) comprising a piston rod (38) having a rack and, at a distal end of the piston rod, a piston head (34) slidably mounted in the barrel (24) along the X-axis; a pawl mounted so as to be movable along the X-axis relative to the reservoir and configured to cooperate with the rack so as to drive the piston along the X-axis only in a forward direction of the piston in the barrel; a spring arranged to push the pawl back along the X-axis in a reverse direction; a case containing the pawl and at least a part of the piston; and a check valve arranged to seal the outlet orifice and allow only an outlet of product from the reservoir.

Abstract: An array of differing microneedles can be accurately achieved including a film having first and second, outwardly facing major surfaces. The first, outwardly facing major surface has a plurality of stratum corneum piercing microneedles extending therefrom, and the plurality of microneedles includes a plurality of first microneedles having a first benefit agent and a plurality of second microneedles having a second benefit agent.

Abstract: A manual injector for skin more easily percutaneously injects into the body liquid nutritional components having skin moisturization, anti-inflammation, skin irritation alleviation, whitening, and anti-wrinkle effects; and a therapeutic agent or an immune activation agent, such as a vaccine, or a skin elasticity nutritional component for skin care. The injector includes: a housing in which liquid nutritional components are charged; a coupling casing mounted to the housing; an opening and closing valve coupled to an inlet hole by passing therethrough and configured to be moveable upward and downward; a bottom casing; a pumping unit having a pressing bar provided therein; a top casing in which a needle hole is formed; and a needle.

Abstract: The present disclosure relates to cap for an injection device. The cap includes a needle shield and a conduit. The needle shield includes a body with a recess for receiving part of a needle syringe. The conduit is movable from an initial position, wherein a portion of the body is located between the recess and the conduit, to a cap removal position, wherein the conduit extends through said portion of the body to fluidly communicate with the recess to allow the ingress of gas into the recess.

Abstract: A mixer assembly with a static mixing element arranged within a mixing channel. The mixer assembly has an inlet end, for receiving components of a substance and a dispensing end for dispensing a mixture from the components. The inlet end comprises for each component an inlet and an associated non-return valve. Each of the inlets is connectable for fluid communication with the mixing channel via the associated non-return valve.

Abstract: A portable medical device for injecting a medicament into a patient. The device includes a control circuit with a memory, the control circuit automatically storing in the memory an ejection event including an amount of the medicament that is ejected from the portable medical device during the ejection event; and a proximity sensor configured to sense proximity of a solid object located in an ejection direction of the portable medical device without making contact with the solid object. The control circuit is configured to tag the ejection event as an injection event if the ejection takes place in proximity of the solid object and to tag the ejection event as a priming ejection if the ejection does not take place in proximity of the solid object.

Abstract: Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug and a stopper. The syringe is housed and/or placed in an encasement. The plunger assembly can include a plunger, an actuator, and a spacer, wherein the plunger assembly is configured to move the stopper a predetermined distance without a user touching the plunger. Methods of assembling and using the syringe devices are also described.

Abstract: A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.

Abstract: In selected embodiments, a handheld injection safety applicator includes an applicator housing with a handle and a retractable needle housed within the applicator. The applicator further includes a first sensor that detects the presence of a user's grip on the handle and a second sensor that detects the presence of an animal. The applicator also includes processing circuitry configured to receive a first signal from the first sensor indicating that the user is gripping the handle and receive a second signal from the second sensor indicating that an animal is detected. The applicator extends the needle out of the applicator into the animal once the first and second signal are received and delivers a dose of medication into the animal once the needle is fully extended into the animal.

Abstract: A method for increasing permeability of a cellular layer of epithelial cells includes contacting the cellular layer with a nanostructured surface including a plurality of first nanostructures arranged thereon and projecting outward therefrom. A fractal dimension of the plurality of nanostructures is greater than 1. The permeability of the cellular layer by a compound is increased as compared to the permeability of the cellular layer prior to contact with the surface.

Abstract: Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.

Abstract: The invention is a cartridge (1, 100) for stereolithography machines (200), which comprises a supporting structure (3) provided with connection means (10) suited to removably connect it to the stereolithography machine (200), a first reservoir (5) suited to contain a material (M1, M2) and provided with a first duct (8) and with a delivery mouth (81) which are suited to place it in communication with a container (4), a feeding unit (7) suited to feed the material (M1, M2) from the first reservoir (5) to the container (4), shutter means (9) suited to close the delivery mouth (81) of the first duct (8), and a second reservoir (12) suited to contain the material (M1, M2). The cartridge (1, 100) furthermore comprises a second duct (13) interposed between the first reservoir (5) and the second reservoir (12) in such a way as to place them in communication with each other.

Abstract: Systems and methods for spraying a liquid treatment solution include a syringe attachment device and a handheld device. The syringe attachment device can be configured to secure a syringe containing the liquid treatment solution. The handheld device can have a movable slide configured to dispense the treatment solution from the syringe. The spray deposition system can include a cover' positioned to provide an impervious barrier between at least a portion of the syringe attachment device and the handheld device. The cover can be attached to the syringe attachment device prior to coupling the devices together. In an example, the cover can have a generally tubular shape with a closed end and an open end. The handheld device can be inserted into the cover and the cover can enclose the handheld device in the assembled position. In an example, the cover can be sterile and at least a portion of the syringe attachment device can be sterile.

Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Abstract: The present invention relates to a three-chambered autoinjector as well as to the methods of administering medicaments to a human using the three-chambered autoinjector. In certain embodiments, the autoinjector includes a first medicament in liquid form, a second medicament preferably in solid form, and a liquid composition for diluting the second medicament, and utilizes a three-chambered design so as to administer the first medicament and a solution comprising the second medicament and the liquid composition at different injection depths into the body of a human. In an alternative embodiment an autoinjector is provided that delivers medicaments at the same injection depth.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A plunger for use with a dispensing syringe to dispense a biomaterial is disclosed. The plunger includes a plunger body having a plunger head at its distal end and a plunger base at its proximal end. The plunger body defines a plunger passageway extending through the plunger body from the proximal end to the distal end. The plunger head is received within a syringe passageway of the dispensing syringe, and the plunger passageway receives a stylet.

Abstract: Systems and methods for spraying a liquid treatment solution include a syringe attachment device and a handheld device. The syringe attachment device can be configured to secure a syringe containing the liquid treatment solution. The handheld device can have a movable slide configured to dispense the treatment solution from the syringe. The spray deposition system can include a cover' positioned to provide an impervious barrier between at least a portion of the syringe attachment device and the handheld device. The cover can be attached to the syringe attachment device prior to coupling the devices together. In an example, the cover can have a generally tubular shape with a closed end and an open end. The handheld device can be inserted into the cover and the cover can enclose the handheld device in the assembled position. In an example, the cover can be sterile and at least a portion of the syringe attachment device can be sterile.

Abstract: Disclosed herein are inflators and methods of using the inflators for inflating inflatable devices, such as balloons, used in medical procedures. Such procedures include angioplasty and the transcatheter delivery of prosthetic heart valves and stents. The inflators overcome the resistances typically generated during such procedures and reduces the force required to fully inflate the balloon.

Abstract: Needle-less extraction of a biospecimen from tissue having a number of tissue layers including an epidermis layer includes creating a first port through a target surface and into an underlying one of the tissue layers, creating a second port through the target surface and into the underlying one of tissue layers, providing an injectate through the first port to the underlying one of the tissue layers underlying the epidermis layer, and extracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port.

Abstract: Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.

Abstract: Syringe systems including barrels having lubricated portions and non-lubricated portions are provided. The non-lubricated portions may be configured to be loaded with injectable materials, such as embolic agents. The injectable materials may comprise polyvinyl alcohol. Also provided are methods of lubricating portions of barrels of syringe systems with lubricants including silicone or silicone-free lubricants.

Abstract: The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.

Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Abstract: Methods for fabricating metallic microneedles are disclosed. One method comprises providing a mold pillar; forming an apertured electrically-conductive layer over the mold pillar; and depositing a metal layer over the electrically-conductive layer to provide an apertured microneedle. Another method comprises providing a mold pillar; depositing a first metal layer over the mold pillar to provide a first microneedle; removing the first microneedle from the mold pillar; and depositing a second metal layer over the mold pillar to provide a second microneedle.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.