Abstract: A medicament delivery device includes a main injection needle for injecting a medicament into the body of a patient. The medicament delivery device includes a pain reduction device for releasing a pain reduction agent into the body of the patient prior the medicament injection. The pain reduction device includes an array of microneedles.

Abstract: Multi-dose dispenser comprising: a product reservoir (14), on the X-axis, opening at a distal end through an outlet orifice and comprising a barrel (24); a piston (20) comprising a piston rod (38) having a rack and, at a distal end of the piston rod, a piston head (34) slidably mounted in the barrel (24) along the X-axis; a pawl mounted so as to be movable along the X-axis relative to the reservoir and configured to cooperate with the rack so as to drive the piston along the X-axis only in a forward direction of the piston in the barrel; a spring arranged to push the pawl back along the X-axis in a reverse direction; a case containing the pawl and at least a part of the piston; and a check valve arranged to seal the outlet orifice and allow only an outlet of product from the reservoir.

Abstract: A manual injector for skin more easily percutaneously injects into the body liquid nutritional components having skin moisturization, anti-inflammation, skin irritation alleviation, whitening, and anti-wrinkle effects; and a therapeutic agent or an immune activation agent, such as a vaccine, or a skin elasticity nutritional component for skin care. The injector includes: a housing in which liquid nutritional components are charged; a coupling casing mounted to the housing; an opening and closing valve coupled to an inlet hole by passing therethrough and configured to be moveable upward and downward; a bottom casing; a pumping unit having a pressing bar provided therein; a top casing in which a needle hole is formed; and a needle.

Abstract: An array of differing microneedles can be accurately achieved including a film having first and second, outwardly facing major surfaces. The first, outwardly facing major surface has a plurality of stratum corneum piercing microneedles extending therefrom, and the plurality of microneedles includes a plurality of first microneedles having a first benefit agent and a plurality of second microneedles having a second benefit agent.

Abstract: The present disclosure relates to cap for an injection device. The cap includes a needle shield and a conduit. The needle shield includes a body with a recess for receiving part of a needle syringe. The conduit is movable from an initial position, wherein a portion of the body is located between the recess and the conduit, to a cap removal position, wherein the conduit extends through said portion of the body to fluidly communicate with the recess to allow the ingress of gas into the recess.

Abstract: A mixer assembly with a static mixing element arranged within a mixing channel. The mixer assembly has an inlet end, for receiving components of a substance and a dispensing end for dispensing a mixture from the components. The inlet end comprises for each component an inlet and an associated non-return valve. Each of the inlets is connectable for fluid communication with the mixing channel via the associated non-return valve.

Abstract: A portable medical device for injecting a medicament into a patient. The device includes a control circuit with a memory, the control circuit automatically storing in the memory an ejection event including an amount of the medicament that is ejected from the portable medical device during the ejection event; and a proximity sensor configured to sense proximity of a solid object located in an ejection direction of the portable medical device without making contact with the solid object. The control circuit is configured to tag the ejection event as an injection event if the ejection takes place in proximity of the solid object and to tag the ejection event as a priming ejection if the ejection does not take place in proximity of the solid object.

Abstract: Described herein are syringe devices comprising a syringe including a therapeutic dose of at least one drug and a stopper. The syringe is housed and/or placed in an encasement. The plunger assembly can include a plunger, an actuator, and a spacer, wherein the plunger assembly is configured to move the stopper a predetermined distance without a user touching the plunger. Methods of assembling and using the syringe devices are also described.

Abstract: A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.

Abstract: In selected embodiments, a handheld injection safety applicator includes an applicator housing with a handle and a retractable needle housed within the applicator. The applicator further includes a first sensor that detects the presence of a user's grip on the handle and a second sensor that detects the presence of an animal. The applicator also includes processing circuitry configured to receive a first signal from the first sensor indicating that the user is gripping the handle and receive a second signal from the second sensor indicating that an animal is detected. The applicator extends the needle out of the applicator into the animal once the first and second signal are received and delivers a dose of medication into the animal once the needle is fully extended into the animal.

Abstract: A method for increasing permeability of a cellular layer of epithelial cells includes contacting the cellular layer with a nanostructured surface including a plurality of first nanostructures arranged thereon and projecting outward therefrom. A fractal dimension of the plurality of nanostructures is greater than 1. The permeability of the cellular layer by a compound is increased as compared to the permeability of the cellular layer prior to contact with the surface.

Abstract: Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.

Abstract: The invention is a cartridge (1, 100) for stereolithography machines (200), which comprises a supporting structure (3) provided with connection means (10) suited to removably connect it to the stereolithography machine (200), a first reservoir (5) suited to contain a material (M1, M2) and provided with a first duct (8) and with a delivery mouth (81) which are suited to place it in communication with a container (4), a feeding unit (7) suited to feed the material (M1, M2) from the first reservoir (5) to the container (4), shutter means (9) suited to close the delivery mouth (81) of the first duct (8), and a second reservoir (12) suited to contain the material (M1, M2). The cartridge (1, 100) furthermore comprises a second duct (13) interposed between the first reservoir (5) and the second reservoir (12) in such a way as to place them in communication with each other.

Abstract: Systems and methods for spraying a liquid treatment solution include a syringe attachment device and a handheld device. The syringe attachment device can be configured to secure a syringe containing the liquid treatment solution. The handheld device can have a movable slide configured to dispense the treatment solution from the syringe. The spray deposition system can include a cover' positioned to provide an impervious barrier between at least a portion of the syringe attachment device and the handheld device. The cover can be attached to the syringe attachment device prior to coupling the devices together. In an example, the cover can have a generally tubular shape with a closed end and an open end. The handheld device can be inserted into the cover and the cover can enclose the handheld device in the assembled position. In an example, the cover can be sterile and at least a portion of the syringe attachment device can be sterile.

Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Abstract: The present invention relates to a three-chambered autoinjector as well as to the methods of administering medicaments to a human using the three-chambered autoinjector. In certain embodiments, the autoinjector includes a first medicament in liquid form, a second medicament preferably in solid form, and a liquid composition for diluting the second medicament, and utilizes a three-chambered design so as to administer the first medicament and a solution comprising the second medicament and the liquid composition at different injection depths into the body of a human. In an alternative embodiment an autoinjector is provided that delivers medicaments at the same injection depth.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A plunger for use with a dispensing syringe to dispense a biomaterial is disclosed. The plunger includes a plunger body having a plunger head at its distal end and a plunger base at its proximal end. The plunger body defines a plunger passageway extending through the plunger body from the proximal end to the distal end. The plunger head is received within a syringe passageway of the dispensing syringe, and the plunger passageway receives a stylet.

Abstract: Systems and methods for spraying a liquid treatment solution include a syringe attachment device and a handheld device. The syringe attachment device can be configured to secure a syringe containing the liquid treatment solution. The handheld device can have a movable slide configured to dispense the treatment solution from the syringe. The spray deposition system can include a cover' positioned to provide an impervious barrier between at least a portion of the syringe attachment device and the handheld device. The cover can be attached to the syringe attachment device prior to coupling the devices together. In an example, the cover can have a generally tubular shape with a closed end and an open end. The handheld device can be inserted into the cover and the cover can enclose the handheld device in the assembled position. In an example, the cover can be sterile and at least a portion of the syringe attachment device can be sterile.

Abstract: Disclosed herein are inflators and methods of using the inflators for inflating inflatable devices, such as balloons, used in medical procedures. Such procedures include angioplasty and the transcatheter delivery of prosthetic heart valves and stents. The inflators overcome the resistances typically generated during such procedures and reduces the force required to fully inflate the balloon.

Abstract: Needle-less extraction of a biospecimen from tissue having a number of tissue layers including an epidermis layer includes creating a first port through a target surface and into an underlying one of the tissue layers, creating a second port through the target surface and into the underlying one of tissue layers, providing an injectate through the first port to the underlying one of the tissue layers underlying the epidermis layer, and extracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port.

Abstract: Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.

Abstract: Syringe systems including barrels having lubricated portions and non-lubricated portions are provided. The non-lubricated portions may be configured to be loaded with injectable materials, such as embolic agents. The injectable materials may comprise polyvinyl alcohol. Also provided are methods of lubricating portions of barrels of syringe systems with lubricants including silicone or silicone-free lubricants.

Abstract: The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.

Abstract: The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojections 4 erected on one support sheet, each microprojection 4 having a drug layer 5 soluble in vivo at its top part and having an intermediate layer 6 under the drug layer 5, the intermediate layer 6 containing a polymeric substance for adhesion of the drug layer 5 to the support sheet, the drug layer 5 at the top part of the microprojection 4 containing a single drug, the microprojections 4 holding difference types of drugs being arranged together on the support sheet 2.

Abstract: A barrel is provided having open proximal end and a closed distal end, and at least one groove in an interior wall thereof. The groove(s) define a length extending a distance from the open end of the barrel toward the distal end of the barrel and defining a substantially constant depth and width along the length thereof. A piston is in sealing engagement with the interior wall of the barrel. The groove(s) permits fluid to bypass the piston when positioned along the groove(s). At least a portion of the piston is positioned distally from the groove(s), thereby sealing substance within the barrel.

Abstract: Methods for fabricating metallic microneedles are disclosed. One method comprises providing a mold pillar; forming an apertured electrically-conductive layer over the mold pillar; and depositing a metal layer over the electrically-conductive layer to provide an apertured microneedle. Another method comprises providing a mold pillar; depositing a first metal layer over the mold pillar to provide a first microneedle; removing the first microneedle from the mold pillar; and depositing a second metal layer over the mold pillar to provide a second microneedle.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: A dispense mechanism for a drug delivery device for the delivery of a primary medicament in a primary cartridge and a secondary medicament in a secondary cartridge includes a primary drive member and a secondary drive member serve for driving a primary and a secondary lead screw. The primary drive member and the secondary drive member are configured to rotate during dose dispense. A coupling member serves for rotationally coupling the primary drive member to the secondary drive member and moves from a first position in which the primary drive member is rotationally decoupled from the secondary drive member into a second position in which the primary drive member is rotationally coupled to the secondary drive member during dose dispense. Rotation of the primary drive member moves the coupling member from the first position into the second position.

Abstract: A cartridge fillable or filled with a dispensable medium for dispensing the medium by movement of a piston receivable or received in the cartridge has a sliding surface for the piston to slide along during the movement of the piston. The sliding surface has a microstructure for reducing the friction between the piston and the sliding surface.

Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.

Abstract: A dental anesthetic buffer assembly advantageously attaches to carpule-loaded syringe in the same manner as a standard disposable needle. The dental anesthetic buffer assembly, however, incorporates a pH-raising buffer that advantageously dissolves into and mixes with the carpule anesthetic during injection, in lieu of pre-mixing the buffer and anesthetic prior to injection.

Abstract: A syringe assembly includes a first syringe having a first syringe outer cylinder filled with a first liquid, and a first gasket; a second syringe having a second syringe outer cylinder filled with a second liquid, and a second gasket; and a pusher assembly which performs a pushing operation of collectively moving the first and second gaskets. The pusher assembly includes a first pusher having a distal portion connected to the first gasket; a second pusher branching from the first pusher, extending distally, having a distal portion connected to the second gasket; and an operation section which is provided on a proximal-side extension line of the first pusher and is operated for the pushing operation.

Abstract: A method of using a medicine injection device including a syringe filled with a medicine; a needle tube having a needle tip for puncturing the skin; a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube; and an absorption part that is disposed in the skin contact portion of the needle hub. The method includes removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the skin contact portion; the absorption part absorbing the spilled medicine staying in the skin contact portion; positioning the skin contact portion adjacent the skin; puncturing the skin with the needle tip; and injecting medicine from the needle tip into the skin.

Abstract: An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid.

Abstract: A container for storing and mixing two components is provided. The container includes a body, a first plug, and a second plug. The body has a first end, a second end, and a bypass with a length L disposed between the first and second ends. The first and second plugs are slidably disposed in the body and define a first compartment. A second compartment is in the body between the second plug and the second end. The second plug has a first edge, a second edge, and a primary conduit extending therein, a plurality of secondary conduits extending from the primary conduit through the second plug. The primary conduit has a first opening. A distance D extends longitudinally from the first edge to the second edge and a distance E extends longitudinally from the first edge to the first opening. D?L and E<L.

Abstract: A plurality of embodiments of mixing syringes are provided. Inventive key to all of the embodiments is a piston valve which divides a barrel to create a pair of chambers in which matter and liquid can be disparately and securely disposed before mixing. Each disclosed piston valve is actuated by force on an associated plunger rod which produces pressure within an associated syringe resulting in a change of the valve state from closed to open. In addition, each such valve comprises check valve action which is permissive to only distal flow through the syringe. Embodiments for both a basic mixing syringe and a mixing syringe with flush are disclosed. Considerations and methods for chamber filling without valve actuation are provided. A mixing syringe system with flush system utilizing a dual chamber syringe having a male luer fitting and a separate diluent containing vessel having a female luer fitting is also disclosed.

Abstract: A priming mechanism for operating an automatic injection apparatus to ensure medication contents are properly delivered prior to a needled syringe of the apparatus being injected. The priming mechanism includes a push rod to move plunger(s) within the syringe; a releasable support including bendable supporting arms, which limiting motion of the syringe relative to an upper housing body before and during priming; and a recess element inside the lower housing body to release said bendable arm to allow motion of the syringe relative to the upper housing body in distal direction after priming. In one form, the priming mechanism is used for removing air bubble before injection to ensure delivering correct dose. In another form, the priming mechanism is used to mix different contents in a dual chamber syringe before injection.

Abstract: An injector for administering a first and a second liquid or pasty substance, in particular a drug, comprises an outer injector body in which an inner injector body is longitudinally displaceably guided in which a plunger is longitudinally displaceably guided. To improve such an injector, the inner injector body has a cuff which sealingly contacts the inner wall of the outer injector body and which can be flowed around by the second liquid or pasty substance when it is in the end position in the outer injector body.

Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

Abstract: An assembly includes a dispensing syringe device configured to receive an amount of biomaterial and to dispense the biomaterial. The dispensing syringe device includes a syringe barrel for receiving the biomaterial, a discharge outlet for dispensing the biomaterial from the syringe barrel, and a plunger received in the syringe barrel. The plunger has a plunger body and a plunger passageway extending therethrough configured to receive a stylet. The assembly further includes a cannulus device configured to be coupled with the dispensing syringe device, to receive biomaterial from the dispensing syringe device, and to dispense the biomaterial. The cannulus device includes a cannulus passageway configured to receive the biomaterial and a dispensing opening configured for dispensing the biomaterial.

Abstract: An endovascular anastomotic connector and method of using the same. The endovascular anastomotic connector includes a vascular conduit and a supply conduit. The vascular conduit has proximal and distal ends that reside within a vascular structure. The supply conduit extends at an angle from the vascular conduit. The proximal end of the supply conduit is configured to be attached to an auxiliary device.

Abstract: A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.

Abstract: The present disclosure relates to a reagent storage device and a bio-reaction apparatus including the same. Provided is a reagent storage device connected to a biochip to provide reagents into the biochip. The reagent storage device includes a storage container having a tube shape of which one end is opened, and the other end opposite to the one end is closed and a plurality of diaphragms provided in the storage container and installed to be closely attached to an inner wall of the storage container. Here, the diaphragms are spaced apart from each other in one direction in which the one end and the other end are disposed opposite to each other, and each of the diaphragms includes a through-hole passing therethrough.

Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.

Abstract: A collapsible syringe assembly for a fluid delivery system is a multi-component device that includes a cylindrical pressure jacket and a collapsible syringe that is received within the pressure jacket. The collapsible syringe includes a cap member and a compressible or deformable sidewall member. The collapsible syringe in one embodiment is adapted to be secured to the pressure jacket by the cap member. The cap member is formed with a discharge port, which may be formed as conventional luer fitting. The discharge port is disposed coaxially within an annular wall on the outward facing side of the cap member and may be recessed within the annular wall.