Having Plural Material Reservoirs Patents (Class 604/191)
  • Patent number: 10449295
    Abstract: A syringe assembly includes a first syringe having a first syringe outer cylinder filled with a first liquid, and a first gasket; a second syringe having a second syringe outer cylinder filled with a second liquid, and a second gasket; and a pusher assembly which performs a pushing operation of collectively moving the first and second gaskets. The pusher assembly includes a first pusher having a distal portion connected to the first gasket; a second pusher branching from the first pusher, extending distally, having a distal portion connected to the second gasket; and an operation section which is provided on a proximal-side extension line of the first pusher and is operated for the pushing operation.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 22, 2019
    Inventors: Kenji Yokoyama, Kunio Fukui
  • Patent number: 10398851
    Abstract: A method of using a medicine injection device including a syringe filled with a medicine; a needle tube having a needle tip for puncturing the skin; a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube; and an absorption part that is disposed in the skin contact portion of the needle hub. The method includes removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the skin contact portion; the absorption part absorbing the spilled medicine staying in the skin contact portion; positioning the skin contact portion adjacent the skin; puncturing the skin with the needle tip; and injecting medicine from the needle tip into the skin.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: September 3, 2019
    Inventors: Yoichiro Iwase, Junichi Ogawa, Kouichi Tachikawa
  • Patent number: 10391257
    Abstract: An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: August 27, 2019
    Assignee: 410 Medical, Inc.
    Inventors: Mark D. Piehl, Galen C. Robertson, John Tyler Willis Hagler, Robert W. Titkemeyer, Frederic C. Feiler, Jr.
  • Patent number: 10327990
    Abstract: A container for storing and mixing two components is provided. The container includes a body, a first plug, and a second plug. The body has a first end, a second end, and a bypass with a length L disposed between the first and second ends. The first and second plugs are slidably disposed in the body and define a first compartment. A second compartment is in the body between the second plug and the second end. The second plug has a first edge, a second edge, and a primary conduit extending therein, a plurality of secondary conduits extending from the primary conduit through the second plug. The primary conduit has a first opening. A distance D extends longitudinally from the first edge to the second edge and a distance E extends longitudinally from the first edge to the first opening. D?L and E<L.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 25, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Marc A. Egeland, Chin-Yee Ng, Jo A. Etter, Ravi Kolakaluri
  • Patent number: 10322235
    Abstract: A plurality of embodiments of mixing syringes are provided. Inventive key to all of the embodiments is a piston valve which divides a barrel to create a pair of chambers in which matter and liquid can be disparately and securely disposed before mixing. Each disclosed piston valve is actuated by force on an associated plunger rod which produces pressure within an associated syringe resulting in a change of the valve state from closed to open. In addition, each such valve comprises check valve action which is permissive to only distal flow through the syringe. Embodiments for both a basic mixing syringe and a mixing syringe with flush are disclosed. Considerations and methods for chamber filling without valve actuation are provided. A mixing syringe system with flush system utilizing a dual chamber syringe having a male luer fitting and a separate diluent containing vessel having a female luer fitting is also disclosed.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: June 18, 2019
    Inventors: Gale Harrison Thorne, Jr., Kendall Patterick Thorne, Gale Harrison Thorne, Sr.
  • Patent number: 10300203
    Abstract: A priming mechanism for operating an automatic injection apparatus to ensure medication contents are properly delivered prior to a needled syringe of the apparatus being injected. The priming mechanism includes a push rod to move plunger(s) within the syringe; a releasable support including bendable supporting arms, which limiting motion of the syringe relative to an upper housing body before and during priming; and a recess element inside the lower housing body to release said bendable arm to allow motion of the syringe relative to the upper housing body in distal direction after priming. In one form, the priming mechanism is used for removing air bubble before injection to ensure delivering correct dose. In another form, the priming mechanism is used to mix different contents in a dual chamber syringe before injection.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: May 28, 2019
    Inventor: Min Wei
  • Patent number: 10293115
    Abstract: An injector for administering a first and a second liquid or pasty substance, in particular a drug, comprises an outer injector body in which an inner injector body is longitudinally displaceably guided in which a plunger is longitudinally displaceably guided. To improve such an injector, the inner injector body has a cuff which sealingly contacts the inner wall of the outer injector body and which can be flowed around by the second liquid or pasty substance when it is in the end position in the outer injector body.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: May 21, 2019
    Assignee: elm-plastic GmbH
    Inventors: Birgit Lonien, Sascha Moehs
  • Patent number: 10226581
    Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: March 12, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Bjorn Wilden, Wolfgang Pelzer
  • Patent number: 10179187
    Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: January 15, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Jafar Golzarian, Lihui Weng
  • Patent number: 10172660
    Abstract: An assembly includes a dispensing syringe device configured to receive an amount of biomaterial and to dispense the biomaterial. The dispensing syringe device includes a syringe barrel for receiving the biomaterial, a discharge outlet for dispensing the biomaterial from the syringe barrel, and a plunger received in the syringe barrel. The plunger has a plunger body and a plunger passageway extending therethrough configured to receive a stylet. The assembly further includes a cannulus device configured to be coupled with the dispensing syringe device, to receive biomaterial from the dispensing syringe device, and to dispense the biomaterial. The cannulus device includes a cannulus passageway configured to receive the biomaterial and a dispensing opening configured for dispensing the biomaterial.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: January 8, 2019
    Assignee: Nordson Corporation
    Inventors: Huadong Lou, Bradley D. Robb, Zachary Rzeszutek, Mark Stevenson
  • Patent number: 10136893
    Abstract: An endovascular anastomotic connector and method of using the same. The endovascular anastomotic connector includes a vascular conduit and a supply conduit. The vascular conduit has proximal and distal ends that reside within a vascular structure. The supply conduit extends at an angle from the vascular conduit. The proximal end of the supply conduit is configured to be attached to an auxiliary device.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: November 27, 2018
    Assignee: CircuLite, Inc.
    Inventor: Robert C. Farnan
  • Patent number: 10130768
    Abstract: A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: November 20, 2018
    Assignee: UNL Holdings LLC
    Inventors: Peter J. Dungar, Molly M. Weaver, Philip A. Weaver, Katlin M. Lumme, Robert E. Johannesson
  • Patent number: 10124340
    Abstract: The present disclosure relates to a reagent storage device and a bio-reaction apparatus including the same. Provided is a reagent storage device connected to a biochip to provide reagents into the biochip. The reagent storage device includes a storage container having a tube shape of which one end is opened, and the other end opposite to the one end is closed and a plurality of diaphragms provided in the storage container and installed to be closely attached to an inner wall of the storage container. Here, the diaphragms are spaced apart from each other in one direction in which the one end and the other end are disposed opposite to each other, and each of the diaphragms includes a through-hole passing therethrough.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 13, 2018
    Assignee: Electronics and Telecommunications Research Institute
    Inventor: Kwang Hyo Chung
  • Patent number: 10117764
    Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent having reservoirs so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue. Features may be incorporated into the walls and bases of these reservoirs to improve securement of the drug construct.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: November 6, 2018
    Inventors: Salvatore G. Caldarise, Carl J. Evens
  • Patent number: 10105491
    Abstract: A collapsible syringe assembly for a fluid delivery system is a multi-component device that includes a cylindrical pressure jacket and a collapsible syringe that is received within the pressure jacket. The collapsible syringe includes a cap member and a compressible or deformable sidewall member. The collapsible syringe in one embodiment is adapted to be secured to the pressure jacket by the cap member. The cap member is formed with a discharge port, which may be formed as conventional luer fitting. The discharge port is disposed coaxially within an annular wall on the outward facing side of the cap member and may be recessed within the annular wall.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: October 23, 2018
    Inventors: Eugene A. Gelblum, Edward J. Rhinehart, Barry L. Tucker, Mark Trocki, John Puskar-Pasewicz, Matthew Beale, Matthew Sass
  • Patent number: 10099015
    Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: October 16, 2018
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Michael Pfoser, Björn Wilden
  • Patent number: 10092695
    Abstract: The presently disclosed subject matter relates to an addition to a medical applicator in general and in particular to an addition to a medical applicator for applying on a surface a curable liquid substance having multi components.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 9, 2018
    Assignees: Ethicon, Inc., Omrix Biopharmaceuticals Ltd.
    Inventors: Erez Ilan, Kfir Regev, Yotam Gurman, Robert J. Tannhauser
  • Patent number: 10085729
    Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 2, 2018
    Assignee: Ethicon, Inc.
    Inventors: Dennis D. Jamiolkowski, An-Min Jason Sung, Leo B. Kriksunov
  • Patent number: 10076611
    Abstract: Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medical injector and an electronic circuit system. The medical injector includes a housing, a medicament container, and a medicament delivery member. The housing defines a first region and a second region. The first region includes the medicament container and is physically isolated from the second region. The electronic circuit system is configured to be disposed within the second region defined by the housing. The electronic circuit system is configured to output an electronic output associated with a use of the medical injector.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 18, 2018
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards, Mark J. Licata, Paul F. Meyers, David A. Weinzierl
  • Patent number: 10039880
    Abstract: A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: August 7, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Marc Holtwick, Ilona Eggert, James Alexander Davies, Simon Lewis Bilton, David Moore, Steven Wimpenny, Christopher Nigel Langley, Jeffrey Zajac
  • Patent number: 10004526
    Abstract: An ultrasonic surgical system is provided. The ultrasonic surgical system includes an ultrasonic instrument that is configured to ultrasonically treat tissue. An ultrasonic generator configured to provide ultrasonic energy to the ultrasonic instrument provides an indication to a user that a specific outcome has been achieved. The indication is output via a device selected from an audio activation end-tone device, a visual activation end-tone device or a tactile activation end-tone device. The ultrasonic generator includes an end-tone outcome indicator module that includes memory having one or more data look up tables that is accessible by a microprocessor associated with the ultrasonic generator.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: June 26, 2018
    Assignee: COVIDIEN LP
    Inventors: Sean T. Dycus, Melissa J. Muszala
  • Patent number: 9999734
    Abstract: In an injection device a rotary indicator element (20) indexes angularly between a pre-firing position to an injection complete position to create a visual and audible/tactile signal as the drive plunger (28) arrives at or near its fired position. The indicator element (20) has a saw tooth profile which co-operates with respective abutments (34, 40) on the plunger and a housing part of the device to control and energize indicator movement.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: June 19, 2018
    Inventor: Toby Cowe
  • Patent number: 9993298
    Abstract: The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: June 12, 2018
    Assignees: Baxter International Inc., Baxter Healthcare, S.A.
    Inventors: Alexander Petter-Puchner, Heinz Redl
  • Patent number: 9987432
    Abstract: A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 5, 2018
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu
  • Patent number: 9950114
    Abstract: A dual-chamber syringe system is disclosed. Critical system oriented elements are disclosed, including plunger valve designs for accurate measurement and true, non-canting displacement; tamper and inadvertent valve actuation indicators, as well as, valve status indicators; anti-reflux construction; novel indicia patterns for dual-chamber syringe operation; structure and method for quality assurance that no gas can be delivered from a proximal chamber of the dual-chamber syringe and a kit for single step dose transfer. In addition, a tapered fitting valve is disclosed. The tapered fitting valve comprises a single molded incompressible, but supple part and a skeletal support whereby the tapered fitting valve is opened by insertion into a tapered fitting. The preferred embodiment of an actuator portion of the valve is elliptical in shape.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: April 24, 2018
    Inventors: Gale Harrison Thorne, Jr., Kendall Patterick Thorne, Gale Harrison Thorne
  • Patent number: 9925118
    Abstract: The invention is related to a manifold comprising at least two valve receptacles, further comprising a fluid groove arrangement comprising at least two fluid grooves, wherein a first fluid groove of the at least two fluid grooves has a starting point near a first valve receptacle of the at least two valve receptacles and an end point near a second valve receptacle of the at least two valve receptacles and wherein a second fluid groove of the at least two fluid grooves has a starting point near a second valve receptacle of the at least two valve receptacles. The invention is further related to an apparatus comprising a manifold of the aforementioned kind and further comprising an inner body of a dispense interface.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: March 27, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Marc Holtwick, James Alexander Davies, Simon Lewis Bilton, David Moore, Steven Wimpenny, Christopher Nigel Langley
  • Patent number: 9919137
    Abstract: An inflation system having two pressure vessels integrated into a balloon catheter. A pressurized chamber and a vacuum chamber are integrally attached to proximal end of the balloon catheter and activated by a common valve or switch. Pressure or vacuum is selectively transmitted to the balloon depending on the valve/switch position. The working fluid may be air, or a combination of air and saline with an intermediate piston/cylinder assembly. The balloon catheter may be a part of a heart valve delivery system with a balloon-expandable heart valve crimped onto the balloon.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: March 20, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventors: Harvey H. Chen, Andrew Phung, Thomas Chien, Da-Yu Chang
  • Patent number: 9889260
    Abstract: The invention relates to a dispense interface comprising a body comprising at least a first channel structure and a second channel structure, wherein each of the at least two channel structures comprises at least a first inlet channel comprising a first inlet opening and a second inlet channel comprising a second inlet opening, wherein each of the at least two inlet openings of one channel structure is configured for fluid communication with a respective reservoir of at least two reservoirs and wherein at least one connecting channel configured for a fluid communication between at least one outlet opening and one of the at least two channel structures is provided.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: February 13, 2018
    Inventors: Frederic Laugere, Cristian Popa, Ben Impey, Andrew MacLeod
  • Patent number: 9878105
    Abstract: The invention provides a dispense interface for an ejection device comprising a first part and a second part, at least a first opening, a second opening and a third opening, a fluidic channel and a connection element for each of the openings, wherein the first part is joined to said second part to form at least a part of said fluidic channel connecting said openings with each other and wherein each connection element is configured to accept a needle assembly for a fluid tight connection with said corresponding opening in order to reduce the complexity and provide an easy usage of the dispense interface and at the same time overcome the problems of material compatibility and cross contamination. The invention also relates to a system comprising a dispense interface according to the invention and a needle assembly for each opening. Furthermore, the invention relates to a method for preparing a dispense interface according to the invention.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: January 30, 2018
    Inventors: Ilona Eggert, Frederic Laugere, Cristian Popa, Ben Impey, Andrew Macleod
  • Patent number: 9872962
    Abstract: Provided are mixing syringes having two chambers defined by a pair of pistons located one above the other inside the syringe. Mixing of components separately stored in each of the two chambers occurs when a reversible valve occluding a bore in the distal piston near the discharge end is unseated by removing the retention sleeve and pressing the knob, and the proximal piston nearer the top of the syringe is moved axially toward the distal piston. Further movement of the proximal piston causes it to abut the distal piston resulting in the two pistons acting as one to dispel the now mixed components through the discharge end. Methods are provided for using the syringes for storage and mixing components; discharging the components from the syringe such as by administering the components to a patient in need thereof through a needle when the components are a medicament product.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: January 23, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Christopher J. Granelli
  • Patent number: 9821118
    Abstract: An automatic mixing device, an actuating device removably mounted to the automatic mixing device and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that initiates spring decompression to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 21, 2017
    Assignee: UNL Holdings LLC
    Inventors: Katlin M. Adlon, Philip A. Weaver, Peter J. Dungar
  • Patent number: 9814841
    Abstract: A medical device having a frontal attachment and a connector housing having or attachable to an associated medical apparatus, the frontal attachment slidably engaging the connector housing and having a forwardly projecting, rearwardly biased needle and a needle retraction assembly, and the connector housing having a needle retraction cavity laterally offset from the needle in a first position, the needle retraction cavity being selectively movable relative to the frontal attachment following use to reposition the needle retraction cavity into alignment with the needle to permit retraction.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: November 14, 2017
    Assignee: Retractable Technologies, Inc.
    Inventors: Thomas J Shaw, Mark Small, Ni Zhu
  • Patent number: 9731085
    Abstract: A cartridge assembly (200) having a shared fastening features for use with a drug delivery device (202). The cartridge assembly includes a cartridge holder (204), a drug cartridge (206), and a connector (208). The connector may be attached to the drug cartridge. The cartridge assembly further includes a fastening means (210, 212) for fastening to a drug delivery device, and this fastening means is shared between the cartridge holder and the cartridge or between the cartridge holder and the connector. The drug delivery device may be a reusable drug delivery device or a disposable drug delivery device.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: August 15, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Thomas Frederick Osman, Richard James Vincent Avery, Joseph Butler, Aled Meredydd James
  • Patent number: 9687599
    Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: June 27, 2017
    Assignee: VALERITAS, INC.
    Inventors: Robert R. Gonnelli, Steven F. Levesque, Ronald V. Nardi
  • Patent number: 9669165
    Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges ?25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 6, 2017
    Assignee: AbbVie Inc.
    Inventors: Sean E. Mackey, Ji Zhou, Martin J. Gibler, Dennis Y. Lee
  • Patent number: 9656022
    Abstract: A combination medication diluting and infuser device in the form of an enteral irrigation syringe having an open-mouthed barrel portion with a piston positioned in the barrel wherein the open mouth of the barrel portion is provided with a replaceable sealing cap and wherein the barrel portion provides a medication-diluting chamber when medication and diluting fluid is introduced into the chamber via the open mouth thereof and can be mixed in the diluting chamber prior to infusing the diluted medication into the patient via a top opening provided in the sealing cap.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: May 23, 2017
    Inventor: Ronald D. Russo
  • Patent number: 9636463
    Abstract: A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: May 2, 2017
    Inventors: Makoto Kakiuchi, Harumi Kakiuchi, Seiji Shimazaki
  • Patent number: 9636035
    Abstract: Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: May 2, 2017
    Assignee: SCIBASE AB
    Inventors: Stig Ollmar, Ulrik Birgersson, Peter Aberg, Ingrid Nicander, Thierry Corman
  • Patent number: 9610410
    Abstract: A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: April 4, 2017
    Assignee: Boehringer Ingelheim MicroParts GmbH
    Inventors: Thorsten Joedicke, Berthold Lange, Thomas Willms, Ying Yu
  • Patent number: 9603782
    Abstract: The present invention relates to an anhydrous composition comprising, in a cosmetically acceptable medium: a) at least hydrophobic silica aerogel particles with a specific surface area per unit of mass (SM) ranging from 500 to 1500 m2/g, preferably from 600 to 1200 m2/g and better still from 600 to 800 m2/g, and a size expressed as the mean volume diameter (D[0.5]) ranging from 1 to 30 ?m; b) at least one solid fatty substance; c) at least one oil; the said composition having a hardness measured at 32° C. and at a humidity of 40% ranging from 15 kPa to 150 kPa and preferably ranging from 20 kPa to 100 kPa. The present invention also relates to a cosmetic process for treating and/or caring for human keratin materials, characterized in that it consists in applying to the surface of the keratin material at least one composition as defined previously.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: March 28, 2017
    Assignee: L'Oreal
    Inventors: Odile Aubrun, Justyna Frelichowska
  • Patent number: 9586044
    Abstract: Disclosed are nanotopography-based methods and devices for interacting with a component of epithelial tissue and increasing the permeability of the tissue. Devices include structures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the components of epithelial tissue.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: March 7, 2017
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Russell Frederick Ross
  • Patent number: 9586005
    Abstract: The present invention relates to a dual syringe delivery device consisting of three components which when collectively assembled result in the capability of accommodating varying syringe volume sizes.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 7, 2017
    Inventor: Dennis L Steffen
  • Patent number: 9561334
    Abstract: A method and an apparatus for applying an anesthetic include an elongated tubular housing having an upper end, a substantially hollow interior, and a lower end having an injection needle extending therefrom. A first chamber is formed within the housing interior for holding an anesthetic cartridge therein. A second chamber receives a cannister containing an endothermic gas that rapidly absorbs heat when released to the atmosphere. The cartridge is penetrated by a plunger that forces the anesthetic through the injection needle. A depressible trigger propels the gas through an outlet nozzle that is oriented to project a stream of gas along a delivery axis that intersects a delivery axis of the needle; therefore, the gas and anesthetic can be successively delivered to an injection site with minimal repositioning of the housing. Accordingly, a dental practitioner can initially disperse the endothermic gas onto the injection site to minimize any pain and discomfort associated with an injection.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: February 7, 2017
    Assignee: Leibovici LLC
    Inventor: Jacob Leibovici
  • Patent number: 9561344
    Abstract: A catheter including an outer conduit and an inner conduit positioned within the outer conduit, the inner conduit having a smaller diameter that that of the outer conduit. A volume between the outer conduit and the inner conduit define a first lumen which may deliver a first fluid to a patient, and an inside diameter of the inner conduit defines a second lumen which may deliver a second fluid to the patient such that the fluid flow of the first fluid and the second fluid exiting the catheter has a flow profile where the first fluid surrounds the second fluid and the second fluid is prevented from contact with inner walls of a blood vessel of the patient in a vicinity of a tip of the catheter.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: February 7, 2017
    Assignee: Bayer HealthCare LLC
    Inventors: Arthur E. Uber, III, Alan D. Hirschman, David M. Griffiths, Frederick W. Trombley, III, David M. Reilly
  • Patent number: 9539391
    Abstract: Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: January 10, 2017
    Assignee: Shi Zi Technology, Ltd.
    Inventors: Martin N. Lee, Jeffrey J. Christian, Michael D. Laufer, Geoffrey H. Willis
  • Patent number: 9526764
    Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 27, 2016
    Inventors: Ulrich Werner, Barbel Rotthauser
  • Patent number: 9486190
    Abstract: A delivery system for delivering multiple components that is assembled using snap-fit assembly and threadless engagement of syringes and associated parts.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: November 8, 2016
    Assignee: Medtronic Xomed, Inc.
    Inventors: Ethan G. Sherman, David J. Little, Wei Chen, John R. Prisco, Matthew J. Friend, Matthew F. Myntti, Tom Zelmer, Cyan Godfrey, Roy Attride
  • Patent number: 9468725
    Abstract: An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: October 18, 2016
    Assignee: Becton, Dickinson and Company
    Inventor: Robert E. West
  • Patent number: 9457142
    Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: October 4, 2016
    Inventors: Shane Alistair Day, Daniel Thomas De Sausmarez Lintell, Steven Wimpenny, Christopher Jones, Aidan Michael O'Hare, Barry Yates, Robert Veasey, Christopher James Smith, Malcolm Boyd, David Martin Leak, Carmen Patricia Keating, David Sanders, Elizabeth Anne Marshall
  • Patent number: 9452279
    Abstract: An inflation device that may comprise multiple plungers is disclosed. The inflation device may have multiple configurations wherein certain plungers are locked with respect to a body of the inflation device while others are configured to be displaceable within the body. Each plunger may be configured with a different effective surface area, allowing a practitioner to vary the amount of force required to attain certain pressures.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: September 27, 2016
    Assignee: Merit Medical Systems, Inc.
    Inventors: Brian Stevens, William Padilla, Steven Weir