Having Plural Material Reservoirs Patents (Class 604/191)
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Patent number: 9526764Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.Type: GrantFiled: October 9, 2009Date of Patent: December 27, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Ulrich Werner, Barbel Rotthauser
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Patent number: 9486190Abstract: A delivery system for delivering multiple components that is assembled using snap-fit assembly and threadless engagement of syringes and associated parts.Type: GrantFiled: October 28, 2011Date of Patent: November 8, 2016Assignee: Medtronic Xomed, Inc.Inventors: Ethan G. Sherman, David J. Little, Wei Chen, John R. Prisco, Matthew J. Friend, Matthew F. Myntti, Tom Zelmer, Cyan Godfrey, Roy Attride
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Patent number: 9468725Abstract: An injection device is provided with dual medicament chambers and a mixing pen needle assembly, whereby predetermined dosages of two medicaments can be provided to a mixing reservoir in the pen needle assembly and delivered simultaneously with the injection device.Type: GrantFiled: April 24, 2013Date of Patent: October 18, 2016Assignee: Becton, Dickinson and CompanyInventor: Robert E. West
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Patent number: 9457142Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.Type: GrantFiled: November 29, 2010Date of Patent: October 4, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Shane Alistair Day, Daniel Thomas De Sausmarez Lintell, Steven Wimpenny, Christopher Jones, Aidan Michael O'Hare, Barry Yates, Robert Veasey, Christopher James Smith, Malcolm Boyd, David Martin Leak, Carmen Patricia Keating, David Sanders, Elizabeth Anne Marshall
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Patent number: 9452279Abstract: An inflation device that may comprise multiple plungers is disclosed. The inflation device may have multiple configurations wherein certain plungers are locked with respect to a body of the inflation device while others are configured to be displaceable within the body. Each plunger may be configured with a different effective surface area, allowing a practitioner to vary the amount of force required to attain certain pressures.Type: GrantFiled: September 9, 2013Date of Patent: September 27, 2016Assignee: Merit Medical Systems, Inc.Inventors: Brian Stevens, William Padilla, Steven Weir
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Patent number: 9440027Abstract: A module assembly for use with an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts the module that has an automatic triggering system activated by a dispense interface needle guard. When the module contains a single dose of a secondary medicament, both the primary and secondary medicaments are delivered through a single dispense interface, preferably a hollow needle. The module assembly does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a trigger automatically activates movement of a lower hub when the needle guard is retracted.Type: GrantFiled: April 19, 2012Date of Patent: September 13, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Garen Kouyoumjian, Malcolm Stanley Boyd, David Richard Mercer, Thomas Urs Thueer
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Patent number: 9381305Abstract: The medical device comprises a wave spring or wave washer in a mechanism to engage or disengage a first element and a second element. The invention also discloses the use of a multiple wave spring or wave washer comprising at least two waved spring layers in a medical device.Type: GrantFiled: March 31, 2010Date of Patent: July 5, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Michael Harms, Steffen Raab, Udo Stauder
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Patent number: 9375562Abstract: The present invention inter-alia relates to an apparatus comprising a diaphragm valve, wherein a diaphragm of said diaphragm valve is made from a substantially rigid material, having at least partially an flexible cross-sectional shape.Type: GrantFiled: May 4, 2012Date of Patent: June 28, 2016Assignee: Sanofi-Aventis Deutschland GmbHInventor: Marc Holtwick
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Patent number: 9352103Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed. The drug delivery device includes a push rod operably connected to a dose dial button. The medicated module includes a housing having a connector configured for attachment to the drug delivery device, and the housing is configured to receive a portion of the push rod when the medicated module is attached to the drug delivery device. The medicated module further includes a reservoir in the housing comprising a single dose of a medicament and a needle guard operably connected to the housing and configured to move in an axial direction during application to an injection site. Still further, the medicated module includes a sleeve in the housing configured to move axially in the housing and a locking collar in the housing configured to move axially and rotationally in the housing.Type: GrantFiled: February 1, 2011Date of Patent: May 31, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: James Alexander Davies, Andrew Gordon Wallace, Malcolm Stanley Boyd, David Sanders
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Patent number: 9333299Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.Type: GrantFiled: February 13, 2014Date of Patent: May 10, 2016Assignee: ARTE CORPORATIONInventors: Atsushi Kanazawa, Katsuyoshi Tuchida, Junichi Komuro, Seiji Shimazaki
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Patent number: 9333302Abstract: A drug delivery device having a collar and a linkage component. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, a single dose setter, a collar, and a linkage component. The variable dose setting mechanism is operably coupled to a primary reservoir holding a first medicament and/or fluid. The fixed dose setting mechanism comprises a fixed dose piston rod that is operably coupled to a secondary reservoir holding a second medicament and/or fluid. Further, the single dose setter is operably coupled to the variable dose setting mechanism, and the collar is disposed on the variable dose setting mechanism. Still further, the linkage component may be disposed on the fixed dose setting mechanism, wherein the linkage component is capable of engagement with the collar. The delivery device is capable of delivering the second medicament and/or fluid by way of at least one discrete pulse of the second medicament and/or fluid.Type: GrantFiled: November 28, 2011Date of Patent: May 10, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Daniel Thomas De Sausmarez Lintell, Garen Kouyoumjian
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Patent number: 9333303Abstract: A drug delivery device having a trigger biasing member that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism that is operably coupled to a primary reservoir holding a first medicament. The drug delivery device also includes a fixed dose setting mechanism that is operably coupled to a secondary reservoir holding a second medicament. The fixed dose setting mechanism comprises a trigger biasing member or spring. In addition, the drug delivery device includes a mechanical coupling that operably couples the variable dose setting mechanism and the fixed dose setting mechanism. During dose setting, activation of a single dose setter sets a variable dose of the first medicament. Setting of a minimum dose of the first medicament causes a fixed dose of the second medicament to be automatically set, and, during dispense, the trigger spring at least assists with the dispense of the fixed dose of the second medicament.Type: GrantFiled: November 28, 2011Date of Patent: May 10, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: David Martin Leak, Malcolm Stanley Boyd
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Patent number: 9321545Abstract: An apparatus for transferring a chosen quantity of medication from a vial to a container under sterile conditions is described. The present invention further facilitates dissolving solid medications contained in the vial or diluting concentrated medications contained in the vial, and transferring the resulting solutions to the container. The container may be an intravenous infuser.Type: GrantFiled: July 9, 2013Date of Patent: April 26, 2016Assignee: Pharmac, LLCInventors: David R. Pestotnik, Christopher M. Tice
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Patent number: 9289272Abstract: A syringe assembly for dispensing medicine from a cartridge having a diaphragm and a piston opposite the diaphragm. The assembly includes a barrel having a hollow interior, an open proximal end, a closed distal end, and an outlet. The assembly also includes a cartridge receiver slidably receivable in the hollow interior of the barrel. The receiver includes an interior space for receiving the cartridge, an access needle extending into the interior space for puncturing the diaphragm of the cartridge. The access needle directs fluid to the barrel outlet. The cartridge receiver includes a plunger rod movable into the interior space of the cartridge receiver for engaging the piston of the cartridge to selectively force medicine in the cartridge through the access needle.Type: GrantFiled: April 4, 2012Date of Patent: March 22, 2016Assignee: Covidien LPInventor: David M. Selvitelli
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Patent number: 9265886Abstract: Medicine injection apparatuses having multiple chambers. The chambers may be in lateral relationship. A torsional part is adapted to turn and be repositioned angularly relative to a main body to allow different chambers to be used to receive an injection assembly. The medicine injector can be constructed to administer multiple doses. The apparatuses may also have a storage chamber for storing the injection assembly after use. Plural drivers may be used to administer multiple doses, such as at the different angular positions of the torsional part. The apparatuses may allow multiple automatic injections from different angular positions and storage of an injector after use. Needle fright is reduced by minimizing exposure of an injection needle prior to injection.Type: GrantFiled: February 1, 2013Date of Patent: February 23, 2016Assignee: Washington Biotech CorporationInventor: Ronald E. Wyrick
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Patent number: 9238107Abstract: A medicated module attachable to a drug delivery device comprises a connecting body configured for attachment to the drug delivery device. A first needle is fixed within the connecting body and a movable needle hub is operatively coupled to the connecting body. A needle guard is operatively coupled to the connecting body and a biasing member is positioned between the connecting body and needle guard. A second needle is fixed within the needle hub. A first cavity within the connecting body defines a reservoir containing at least one dose of a medicament. The reservoir configured for fluid communication with the first and the second needle. The reservoir comprises a bypass configured to allow medicament from the drug delivery device to bypass the reservoir and exit the second needle.Type: GrantFiled: June 1, 2010Date of Patent: January 19, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
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Patent number: 9233776Abstract: A pharmaceutical transport container includes a first body portion adapted to receive at least a portion of a pharmaceutical vial, a second body portion removably engaged with the first body portion to fully enclose the vial, and a flexible ring positioned in an interior cavity of the second body portion and configured to flex between a relaxed state and a radially-outward extended state. The pharmaceutical transport container may also include a removable end cap having a receiving chamber to receive the first body portion, and/or a guide tab extending from an exterior surface of the second body portion to engage a guide slot defined in a fluid injection system docking station, whereby the transport container translates axially and rotationally into the docking station to establish a fluid connection between the vial and a fluid connector mechanism or element disposed within the docking station.Type: GrantFiled: March 13, 2013Date of Patent: January 12, 2016Assignee: Bayer HealthCare LLCInventors: Jason L Bazala, Ryan C Kaintz
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Patent number: 9180240Abstract: This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a medical fluid pumping system includes a medical fluid pumping machine including a piston head that can be linearly displaced and a medical fluid cassette that can be secured to the medical fluid pumping machine. The medical fluid cassette includes a fastening member attached to a region of a flexible membrane overlying a fluid pump chamber, and the piston head is configured to be mechanically connected to the fastening member of the cassette.Type: GrantFiled: April 9, 2012Date of Patent: November 10, 2015Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Sean Farrell, Tri Ly, Gurpreet Singh, Kulwinder S. Plahey, DeLoy Lindley, Ignacio Serrato, Venugopal Raghavendra Ghatikar, Michael David Young
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Patent number: 9174006Abstract: A dermal access device for fluid injection comprising a bearing block for fixation of the device onto a patient's skin, a slider movably connected to the bearing block and a hollow needle arranged at the slider for puncturing the skin, wherein the needle creates a puncture angle with respect to the skin surface when puncturing the skin, which does not exceed 25°. A dermal access device for fluid injection comprising a bearing block for fixation of the device onto a patient's skin, a movable slider connected to the bearing block and a hollow needle arranged at the slider for puncturing the skin, wherein the device comprises a first stop for limiting a first moving direction of the slider at a first puncture position of the needle, where the device comprises a second stop at a second puncture position of the needle for limiting the second moving direction of the slider.Type: GrantFiled: February 1, 2011Date of Patent: November 3, 2015Assignee: Hahn-Schickard-Gesellschaft Fur Angewandte Forschung E.V.Inventors: Michael Vosseler, Kai Hiltmann, Michael Jugl
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Patent number: 9114215Abstract: Various syringe systems are disclosed. One illustrative syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to house a plurality of fluids therein. A first plunger may be positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body.Type: GrantFiled: March 13, 2013Date of Patent: August 25, 2015Assignee: Bayer Medical Care Inc.Inventors: Kevin P. Cowan, Edward J. Rhinehart, Anthony S. McCoppin, Barry L. Tucker
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Patent number: 9084997Abstract: There are provided a capsule and a chemical reaction cartridge capable of properly handling reagents and so forth. The capsule is formed by laminating two dome-shaped films together at the peripheries thereof. The films are formed by subjecting heat sealable films, to which aluminum vapor deposition is applied, to a drawing process. The films are made of a material (easy-peel material), which can be varied in seal strength by a heating temperature and are thermally welded together at an adhesion area at the peripheries thereof. Thereafter, contents such as reagents and so forth are filled up inside the capsule via a filling section.Type: GrantFiled: July 26, 2011Date of Patent: July 21, 2015Assignee: YOKOGAWA ELECTRIC CORPORATIONInventors: Takeo Tanaami, Hisao Katakura, Nobuyuki Kakuryu, Saya Satou
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Patent number: 9050444Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.Type: GrantFiled: February 7, 2013Date of Patent: June 9, 2015Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Morteza Gharib, Adrianus I. Aria, Elijah Bodhi Sansom
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Publication number: 20150141928Abstract: The invention relates to a dispense interface for an ejection device comprising a first part and a second part, at least a first opening, a second opening and a third opening, a fluidic channel and a connection element for each of the openings, wherein the first part is joined to the second part to form at least a part of the fluidic channel connecting the openings with each other and wherein at least one connection element is configured to accept a needle assembly for a fluid tight connection with the corresponding opening and wherein at least one connection element is configured to provide a releasable push fit connection for a fluid tight connection with an ejection device in order to reduce the complexity and provide an easy usage of the dispense interface and at the same time overcome the problems of material compatibility and cross contamination. The invention also relates to a system with a dispense interface according to the invention.Type: ApplicationFiled: May 16, 2013Publication date: May 21, 2015Inventors: Frederic Laugere, Cristian Popa, Ben Impey, Andrew MacLeod
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Patent number: 9033933Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a single hollow needle. The medicated module is configured so that it will first deliver both the primary and secondary medicaments and then, if needed, a dose(s) of additional primary medicament. The module also contains a needle guard that locks the first dose delivery, but can be manually overridden by a user to perform a second or subsequent injection of primary medicament.Type: GrantFiled: February 1, 2011Date of Patent: May 19, 2015Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Malcolm Stanley Boyd, James Alexander Davies, Daniel Thomas De Sausmarez Lintell
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Publication number: 20150126961Abstract: The invention inter alia relates to a dispense interface for an ejection device. The dispense interface comprises at least two inlets, at least one outlet and a part having multiple portions; wherein the multiple portions are connected by living hinges such that the multiple portions are foldable towards each other; wherein the multiple portions are configured to form a fluid channel arrangement between functional surfaces of the multiple portions facing each other when the multiple portions are folded towards each other; wherein at least two functional surfaces of the functional surfaces are inclined to each other when the multiple portions are folded towards each other; and wherein the fluid channel arrangement is configured to provide fluid communication between the at least two inlets and the at least one outlet.Type: ApplicationFiled: May 16, 2013Publication date: May 7, 2015Inventors: Frederic Laugere, Cristian Popa, Ben Impey, Andrew Macleod
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Patent number: 9022987Abstract: A dispensing device which disperses medicate through a needle across a zone within a body with zero pressure differential. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a therapeutic agent reservoir in fluid communication with the needle, positioned within said housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the therapeutic agent reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with said reservoir-connecting conduit, and a linear drive attached to said needle or to said needle-receiving member.Type: GrantFiled: November 17, 2011Date of Patent: May 5, 2015Assignee: Gabriel Institute, Inc.Inventors: Stanley D. Stearns, H. Max Loy, Jr., Donald G. Davis
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Patent number: 9011377Abstract: The control device is used to control delivery of fluids from a multi-fluid delivery system during a medical injection procedure. The fluid delivery system includes an injector used to deliver injection fluids to a patient. The control device is operatively associated with the injector for controlling discrete flow rates of injection fluids delivered to the patient. The control device includes a housing, first and second actuators associated with the housing, and an electronic substrate disposed within the housing and having a conductive pattern. The first actuator is operatively associated with the conductive pattern. The conductive pattern includes a plurality of predetermined digital values corresponding to discrete flow rates of injection fluids to be delivered by the injector. The second actuator is operatively associated with the electronic substrate and initiates output signals to the injector corresponding to desired mixture ratios of the injection fluids to be delivered by the injector.Type: GrantFiled: November 5, 2008Date of Patent: April 21, 2015Assignee: Bayer Medical Care Inc.Inventors: Ralph H. Schriver, Thomas P. Joyce, Michael Riley, William D. Barlow
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Publication number: 20150105475Abstract: The present disclosure relates to devices and methods for the preparation of amyl nitrite formulations at a point of use location from relatively shelf-stable reagents employing acidic cationic exchange resins.Type: ApplicationFiled: October 15, 2013Publication date: April 16, 2015Inventors: Joseph A. McDONOUGH, Darrel W. JOHNSTON, Paul M. THOMPSON
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Patent number: 8998856Abstract: A cartridge holder is presented having a first cartridge retainer, at least a second cartridge retainer and a locking device for each cartridge retainer, wherein each cartridge retainer is configured to receive a medicament reservoir and wherein each cartridge retainer is movable between a closed and an open position, wherein the locking devices are configured to lock and unlock the cartridge retainers in the closed position and wherein the locking devices are configured to operate such that only one of the cartridge retainers at a time is movable into the open position. An apparatus is also presented that has a main body and a cartridge holder, wherein the cartridge holder is removably attached to the main body. A method for inserting of a medicament reservoir in a cartridge holder or in an apparatus is also described.Type: GrantFiled: May 24, 2012Date of Patent: April 7, 2015Assignee: Sanofi-Aventis Deutschland GmbHInventors: Ilona Eggert, Shane Alistair Day, Daniel Thomas De Sausmarez Lintell, Steven Wimpenny, Alasdair Mackellar
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Publication number: 20150094689Abstract: The present invention relates to a dual syringe delivery device consisting of three components which when collectively assembled result in the capability of accommodating varying syringe volume sizes.Type: ApplicationFiled: September 30, 2013Publication date: April 2, 2015Inventor: Dennis L. Steffen
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Patent number: 8992505Abstract: Apparatus and methods for providing a field environment filled proximal chamber of a multi-chamber syringe and for filling a prime-free syringe are disclosed. In addition, methods for resetting valves of a multi-chamber syringe without special tools or insertion of foreign objects into the syringe are disclosed. A valve for interfacing with syringes telescopically inserted into a larger syringe and which are generally used as proximal chambers in multi-chamber syringes used in mixing and serial delivery applications is disclosed. Four embodiments of novel resettable valves are disclosed. Also, a syringe assembly for delivering a saline-dose-saline medication sequence is disclosed.Type: GrantFiled: August 29, 2012Date of Patent: March 31, 2015Assignee: Thorne Consulting & Intellectual Property, LLCInventors: Gale H. Thorne, Jr., Gale H. Thorne
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Patent number: 8979791Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.Type: GrantFiled: June 1, 2010Date of Patent: March 17, 2015Assignee: Sanofi-Aventis Deutschland GmbHInventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
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Publication number: 20150051582Abstract: A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.Type: ApplicationFiled: October 29, 2014Publication date: February 19, 2015Inventors: Ronald J. Pettis, Frank E. Martin, Scott A. Kaestner
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Publication number: 20150047631Abstract: A medicament delivery device for a disposable container having at least one chamber for a liquid medicament encapsulated in the container by at least one movable plunger. The medicament delivery device is elongated along a longitudinal axis (A), has proximal and distal ends, and includes a housing with proximal housing section configured for accommodating the disposable container and a distal housing section; a plunger rod configured for contacting the movable plunger; and a drive mechanism arranged in the distal housing section for applying, when the medicament delivery device is activated, a force on the movable plunger in a proximal direction via the plunger rod. The plunger rod includes an outer periphery having at least two axially separated recesses or cut-out portions for retaining liquid medicament that leaks along the plunger rod toward the drive mechanism.Type: ApplicationFiled: March 7, 2013Publication date: February 19, 2015Applicant: CAREBAY EUROPE LTDInventor: Jonas Norebring
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Publication number: 20150025493Abstract: The invention relates to a method for delivering at least one fluid medicament from a medical device. The invention also relates to a medical device. The technical problem of improving the dose accuracy is solved by a method for delivering at least one fluid medicament from a medical device comprising a first reservoir containing a first fluid medicament, a second reservoir containing a fluid, and a fluid element connected to said first reservoir and said second reservoir. The method comprises receiving information about a desired dose of the first fluid medicament to be ejected, adjusting said dose to be ejected from said first reservoir based at least in part on information about a content of said fluid element, and ejecting said adjusted dose from said first reservoir through said fluid element. The technical problem is further solved by a medical device configured to work according to the method.Type: ApplicationFiled: November 21, 2012Publication date: January 22, 2015Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Ilona Eggert, Michael Caspers, Daniel Thomas De Sausmarez Lintell
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Patent number: 8936577Abstract: Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.Type: GrantFiled: January 23, 2012Date of Patent: January 20, 2015Assignee: Shi Zi Technology, Ltd.Inventors: Martin N. Lee, Jeffrey J. Christian, Michael D. Laufer, Geoffrey H. Willis
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Publication number: 20150011943Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.Type: ApplicationFiled: September 25, 2014Publication date: January 8, 2015Applicant: MERIAL LIMITEDInventors: Robert William Lachlan Holmes, Rodney Gordon Walker, Todd Donald Ebbett, Colin Anthony Standing, Peter Robert Williams, Giovanni Ciampa, Michael Rossignuolo, Robert John Smith
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Patent number: 8926567Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.Type: GrantFiled: December 19, 2011Date of Patent: January 6, 2015Assignee: Fred Hutchinson Cancer Research CenterInventors: S. Bahram Bahrami, Mandana Veiseh, James Olson
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Patent number: 8911395Abstract: A syringe carpule for storing, transporting and in situ mixing of a local anesthetic, such as lidocaine, and a buffer, such as sodium bicarbonate, and delivery of buffered anesthetic solution according to the present invention that comprises a hollow tubular body received within the frame of a carpule syringe, at least one axially movable plunger within the body and configured to be engaged and moved by a rod of the carpule syringe, a seal pierced by a rear portion of a needle coupled to the carpule syringe, a first chamber within the body filled with anesthetic solution during storing and transport, a second chamber defined within the body filled with buffering solution during storing and transport; and a breachable separating member between the first and second chamber configured to be removed for in situ mixing of the buffering and the anesthetic solutions allowing for delivery of a buffered anesthetic solution.Type: GrantFiled: November 1, 2012Date of Patent: December 16, 2014Inventor: George Just
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Publication number: 20140364831Abstract: A revolving multi-cartridge syringe device includes a needle and two or three revolving holders, each for receiving a cartridge containing medical fluid to be injected. The holders can be pre-loaded with the cartridges, with a first cartridge placed in a loaded position ready to dispense. After fluid in the first cartridge is injected into a patient, a second holder and cartridge are revolved into the loaded position, without breakdown of the syringe. The process can be repeated with a third cartridge. The engagement of each cartridge with the needle, retraction from the needle, and rotation of the revolving holder are all implemented by sliding a sliding actuator in either a first direction or a second, opposite, direction, depending on which action is desired. Thus, injection and reloading of the cartridges can be easily actuated by the user through manipulation of a single slidable actuator, without requiring withdrawing the needle from the mouth area to reload.Type: ApplicationFiled: February 12, 2013Publication date: December 11, 2014Inventor: Nicholas CIANCARELLI
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Publication number: 20140341838Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.Type: ApplicationFiled: July 30, 2014Publication date: November 20, 2014Inventors: Natalie Artzi, Elazer R. Edelman, Nuria Oliva Jorge, Maria Carcole Solanes
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Patent number: 8888749Abstract: Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees.Type: GrantFiled: March 5, 2012Date of Patent: November 18, 2014Assignee: Confluent Surgical, Inc.Inventors: Patrick Kenneth Campbell, Arthur J. Driscoll, Tom Guest
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Publication number: 20140336586Abstract: A drug delivery assembly comprises a housing (110), a piston (120) axially displaceable in the housing, and a variable volume reservoir (105) formed by the housing and the piston and containing a fluid first drug. The assembly further comprises an exterior fluid inlet (150) arranged in or configured to be arranged in fluid communication with the reservoir, a fluid outlet (145) arranged in or configured to be arranged in fluid communication with the reservoir, biasing means (130) configured for moving the piston forwards, and releasable retaining means (113) configured for retaining the piston in an initial position, whereby the biasing means is allowed to move the piston forwards to expel fluid drug from the reservoir when the retaining means is released.Type: ApplicationFiled: November 30, 2012Publication date: November 13, 2014Applicant: NOVO NORDISK A/SInventors: Henrik Bengtsson, Jonas K. Pedersen, Rikke B. Andersen, Jeppe Sturis, Kezia A. Juul, Lars Eilertsen, Ulla Ribel-Madsen
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Publication number: 20140336580Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.Type: ApplicationFiled: July 28, 2014Publication date: November 13, 2014Applicant: Valeritas, Inc.Inventors: Robert R. GONNELLI, Steven F. LEVESQUE, Ronald V. NARDI
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Patent number: 8876021Abstract: An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber.Type: GrantFiled: February 4, 2013Date of Patent: November 4, 2014Assignee: Confluent Surgical, Inc.Inventors: Jason Fortier, Les Hull, Art Driscoll
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Publication number: 20140322279Abstract: The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides.Type: ApplicationFiled: April 28, 2014Publication date: October 30, 2014Applicant: Massachusetts Institute of TechnologyInventors: Yoshiyuki Kumada, Shuguang Zhang
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Patent number: 8870028Abstract: A dispensing device is disclosed having an ampoule with at least four storage lumens extending axially along the length of an ampoule body, a mixing tip coupled to a distal end of the storage lumens, the mixing tip having at least four gasket seats formed therein, each gasket seat corresponding to one of the storage lumens, and an outlet lumen in fluid communication with the storage lumens.Type: GrantFiled: January 10, 2013Date of Patent: October 28, 2014Assignee: Restek CorporationInventors: Thomas E. Kane, Brian A. Jones
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Publication number: 20140316342Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.Type: ApplicationFiled: February 13, 2014Publication date: October 23, 2014Inventors: Atsushi KANAZAWA, Katsuyoshi Tuchida, Junichi Komuro, Seiji Shimazaki
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Publication number: 20140296791Abstract: The present invention relates to a pre-filled, syringe-like device to delivery multiple fluids (liquid and gas). Different segment of fluids are stored separated and then dispensed sequentially from the device when the plunger of the syringe is pressed. To enable the sequential delivery of pre-filled fluids, the invention includes a novel placement of connector hub(s) on the side of the barrel to allow it to function as intended. This allows fluids to be stored in a single body but in separate compartments and the fluids can be sequentially dispensed by a single plunging mechanism. This is in contrast to other dispensing methods where multiple steps are needed to sequentially dispense the fluids out of the container. In other invention, multiple barrels structures and manifold are also needed to perform sequential delivery. At the connectors, syringe needles, tubing, or a misting-delivering nozzle can be coupled to provide the user-desired dispensing patterns.Type: ApplicationFiled: February 27, 2014Publication date: October 2, 2014Inventor: Season Sze-Shun Wong
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Patent number: 8839828Abstract: A system having a medication reservoir for a medication dosing apparatus for administering a liquid medication, and having a medication supply container holding the liquid medication, a filling device being provided for the automatic filling of the medication reservoir with the medication coming from the medication supply container. Fluidic connections may be provided between individual components for transfer and filling of the liquid medication. This system for administering a medication has the advantage that reliable and simple filling of the medication may be performed.Type: GrantFiled: November 17, 2008Date of Patent: September 23, 2014Assignee: Robert Bosch GmbHInventors: Dick Scholten, Michael Stumber