Abstract: A protective cap is presented that is releasably connected to a medicament delivery device, which medicament delivery device is provided with an activator element at a proximal end thereof, the protective cap has first positive holding elements arranged on an inner surface of the protective cap, which first holding elements are designed to interact with second holding elements, arranged on an outer surface of the activator element of the medicament delivery device.

Abstract: An antiseptic dead-end cap includes a base having first and second sides, a first annular wall extending from the first side of the base, a cylindrical center plug extending from the first side of the base, and a second annular wall extending from the second side of the base. The first annular wall has an outer and an inner surface. The cylindrical center plug has an outer and an inner surface, and is positioned within the first annular wall to form an annular chamber. The second annular wall has an outer and an inner surface, and defines a second chamber having an open end. The second chamber is further defined by the inner surface of the cylindrical center plug. An antiseptic material is on at least one of the first annular wall inner surface, second annular wall inner surface, second annular wall outer surface, and cylindrical center plug outer surface.

Abstract: Disclosed herein are devices, systems, and methods thereof for minimizing or preventing contamination of sterile medical devices during magnetization thereof. For example, a magnetizer cover is disclosed for maintaining sterility of a medical device while magnetizing the medical device. The magnetizer cover includes a base, a funnel extending from the base, and a grip tab extending from the base. The base includes a medical-device interface and a magnetizer interface opposite the medical-device interface. The funnel includes a funnel stem configured to protect an elongate medical device from contacting a magnetizer when the medical device is inserted into the funnel. The grip tab is configured for manipulating the magnetizer cover.

Abstract: Described is a medicament delivery device comprising a case adapted to hold a container with a medicament and having a needle, a needle sleeve telescopically coupled to the case and having a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered, a first indicia disposed on the needle sleeve which is visible in the first extended position and the second extended position, and a second indicia disposed on the needle sleeve and not visible in the first extended position and visible the second extended position.

Abstract: Described is a medicament delivery device comprising a case adapted to hold a container with a medicament and having a needle, a needle sleeve telescopically coupled to the case and having a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered, a first indicia disposed on the needle sleeve which is visible in the first extended position and the second extended position, and a second indicia disposed on the needle sleeve and not visible in the first extended position and visible the second extended position.

Abstract: The present invention relates to an injection device that includes a housing having an axis, and a needle sleeve that is axially movably within the housing. Axial movement of the needle sleeve into the housing is configured to actuate an injection process. The needle sleeve includes a first part that is slidably mounted to the housing, and a second part that protrudes from the housing and is rotationally coupled to the first part. The needle sleeve includes a locking mechanism that is configured to prevent axial movement of the needle sleeve into the housing until the second part of the needle sleeve has been rotated relative to the first part of the needle sleeve.

Abstract: A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The packaging assembly further comprises a first chamber defined in part by the cap member and arranged for receiving the cannula such that at least a distal end of the cannula is sealed in the first chamber when the cap member is in place, and a second chamber defined in part by the sealing element and arranged for receiving the release member.

Abstract: Autoinjectors and methods of injection are described that feature release mechanisms and/or end-of-dose sound which can operate in conjunction with a powered plunger to efficiently inject a controlled dose from a syringe.

Abstract: A two piece adapter for extrusion of cylindrical core-shell structures using conventional biomedical needles includes first and second adapter pieces. The first adapter piece includes first and second (core and shell) inlet ports. The core inlet port leads directly to a male Luer fitting attachable to a core needle and surrounded by a threaded chamber. The shell inlet port is led, via a side chamber, into the side of the threaded chamber. The second adapter piece attaches to the bottom of the threaded chamber and is configured to attach to a shell needle, so that the shaft of the core needle sits inside the shaft of the shell needle.

Abstract: A multi-purpose automatic injector, comprising a base unit having a forward end and a rearward end and arranged along a longitudinal axis; a cartridge containing a medicament, the cartridge being coupled adjacent to the forward end of the base unit; a drive assembly attached to the base unit and configured to be actuated by a computerized controller; at least one piercing element configured to be operatively coupled with the drive assembly and configured to be movable by the drive member relative to the cartridge in a reciprocating manner upon receipt of a corresponding signal from the computerized controller.

Abstract: A pen needle (30, 110) is disclosed for coupling to a delivery device (10) and piercing a septum on the delivery device. The pen needle includes a collar (32, 112) having a side wall (36, 116), an open proximal end (38), and a distal end (40, 118) having a coupling member (50). The pen needle also includes a needle hub (34, 114) having a proximal end (50, 124) and a distal end (58, 126), where the proximal end of the needle hub has a coupling member coupled to the distal end of the collar. The needle hub rotates independently of the collar. A needle (52) extends from the distal end of the needle hub, and a projection (76, 126) extends from the proximal end of the needle hub for piercing a septum (106) of a delivery device. The collar (32, 112) rotates independently from the needle hub (34, 114) so that the collar screws onto the threaded end of the delivery device while the needle hub does not rotate and the projection advances to pierce the septum (106) without rotating.

Abstract: Powered drivers (10) for inserting an intraosseous device (160) into a bone and associated bone marrow are disclosed. Some of the powered drivers (10) may include a housing (12) having a distal end (14) and a proximal end (16); a motor (18) disposed in the housing (12); a driveshaft (34) extending outward from the distal end (14) of the housing in a direction away from the proximal end (16); a gearbox (32) coupled to the motor (18) and to the driveshaft (34) such that activation of the motor (18) causes the driveshaft (34) to rotate; and a power source (40) configured to power the motor (18). A guard member (50) may be pivotably connected to the housing (12) and movable between a protective position and a non-protective position. The guard member (50) may be configured to cover the intraosseous (10) needle assembly in the protective position and to expose the intraosseous (10) needle assembly in the non-protective position.

Abstract: An automatic drug delivery device is described, comprising: a housing (1); a skin sensor element (15) coupled to the housing and movable relative to the housing, wherein the skin sensor element is biased into a front position relative to the housing and is movable to a rear position relative to the housing when the skin sensor element is pressed against an injection site; a needle assembly comprising a hypodermic needle (11), the hypodermic needle extending outside of the housing when the device is in a needle insertion configuration; a drug delivery mechanism comprising a stored energy source (4), within the housing; wherein the drug delivery mechanism is released when the skin sensor element is moved from the front position towards the rear position and wherein the stored energy source is arranged to expand along an axis that is offset from an axis of travel of the needle assembly in use; a needle retraction mechanism configured to withdraw the hypodermic needle into the housing when the needle retraction m

Abstract: The disclosure relates to a drug delivery device, comprising: an outer needle sleeve; a cartridge containing a dosage of a medicament and sealed with a sealing element that is arranged across an open distal end of the cartridge; a cartridge carrier adapted to hold the cartridge; a needle hub adapted to hold a double ended hollow needle; an inner needle sleeve arranged between the needle hub and the cartridge carrier; a removable cap coupled to the inner needle sleeve and adapted to cover and seal the needle; and a first locking mechanism adapted to lock the inner needle sleeve against axial movement in the proximal direction with respect to the cartridge carrier in an initial state, wherein in the initial state, the needle is spaced from the cartridge in the distal direction, and wherein the first locking mechanism is releasable by a rotational movement of the cap with respect to the outer needle sleeve.

Abstract: The present invention relates to an opening and liquid supplying system (100) for pre-filled containers (10, 30) equipped with a supplying end, comprising a coupling element (20), connecting means (6) movable from a first position to a second position, and movable protection means (9); the coupling element (20) has an end (27) closed and suitable for being punched, and first guiding means (21) for guiding the movement of the connecting means (6) movable from the first position, close to the closed end (27), to the second position, apart from such end, and vice versa; the connecting means (6) have engaging means (7) for engaging with the protection means (9) so as to move integrally along a second degree of freedom, different than the first degree of freedom, and first matches (11) for the first guiding means (21). The invention relates also to a respective pre-filled container equipped with such system and the method for realize them.

Abstract: A drug injection device (10) including a housing (12) for holding a container (20) having a needle (24) for penetrating skin and a plunger (42) for expelling a drug stored in the container. The device includes visual and/or audible indicators for indicating that the correct depth of needle penetration has been achieved and that drug injection/extrusion has been started and/or completed. The device may further include a label (140) for visually confirming the quality of the drug contained therein. Alternatively, a tray (110) may be provided for receiving the drug injection device, which allows the quality of the drug contained therein to be visually confirmed.

Abstract: A slip luer assembly includes a hub member and a latch member coupled to the hub member. The hub member includes an outer hub surface, an inner hub surface and a window surface. The window surface defines a window extending from the outer hub surface to the inner hub surface. The latch member includes at least one blade. The latch member is configured to be actuated between a first position and a second position. In the first position, the at least one blade is not positioned within the window of the hub member. In the second position, the at least one blade is positioned at least partially within the window of the hub member.

Abstract: An inventive medical device for transcutaneously inserting a cannula into body tissue. The device has a cannula with a wall that at least partially encloses a lumen. The device also has a patch for mounting onto skin of a user. The patch has a base and has a reservoir for storing a medical fluid. The patch also has a spring driven inserter. The inserter has a drive that urges the cannula from a storage position within the patch to an inserted position within the body tissue. The inserter also has a lock configured for securing the drive in a fixed position. The lock is fixedly connected to the drive and has a snap closure. Also disclosed is a medication pump that is fluidly connectable to the cannula. A method of transcutaneously using the medical device to transcutaneously insert a cannula into body tissue is also disclosed.

Abstract: This relates to an injection device comprising a housing for receiving a product container, which has a rigidly connected injection needle, and a cap for removing a needle protection cap from the product container. The cap comprises an engagement element in order to carry out the removal of the needle protection cap from the product container while removing the cap from the injection device. The cap further comprises a rotating sleeve, wherein the rotating sleeve has a reverse rotation protection element, and the engagement element or the housing has a reverse rotation protection counter-element in order to allow a rotation of the rotating sleeve in one direction and block the rotation in the opposite direction.

Abstract: The present specification relates to a subassembly for a drug delivery device, the subassembly comprising: a housing adapted to contain a drug container with a needle, a cap, and a spacer, wherein the housing has an inner surface forming a cavity configured to retain the drug container, wherein the cap is configured to be releasably connected to the housing, and wherein the spacer is arranged between the cap and the housing.

Abstract: A safety needle has a needle base, a puncture needle, and a safety cap. The puncture needle is inserted into a front end of a needle connection segment of the needle base. The safety cap is combined with a front end of the needle base. The safety cap has a needle cap and a resilient member mounted in the needle base. The needle cap is mounted around the puncture needle. Guiding blocks formed on the rear end of the needle cap are mounted respectively in positioning recesses in a housing of the needle base. The needle cap and an outer cap are mounted around the puncture needle, and the puncture needle can be kept from exposure. The needle cap can be locked with the positioning recesses, and the safety needle cannot be reused and can be distinguished as a used needle.

Abstract: An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

Abstract: Described is an injection device (1) for administering a drug, the injection device (1) comprising a cartridge holder (2) adapted to receive a drug cartridge (3), a hollow injection needle (6) having a proximal tip (6.2) adapted to pierce a septum (4) of the cartridge (3) so as to establish a fluid communication between the cartridge (3) and the needle (6), and a cap (7) arrangeable over the cartridge holder (2) in a manner to cover the needle (6). In an initial state the cartridge (3) is arranged within the cartridge holder (2) with the septum (4) axially spaced from the proximal tip (6.2) of the needle (6). The cap (7) is adapted to move the needle (6) relative to the septum (4) for piercing it on movement of the cap (7) relative to the cartridge holder (2).

Abstract: A removal member for removing a needle protective cap includes a housing having a longitudinal axis and receiving the cap along an insertion direction, the housing having a first support area and a second support area the first area being carried by a blocking element, movable relative to the housing between a cap insertion configuration, in which the orthogonal projections of the first and second areas in a transverse plane substantially perpendicular to the longitudinal axis are separated by an insertion distance, and a cap blocking configuration, in which the first and second areas are located in separate transverse planes, and in which the orthogonal projections of the first and second areas in said transverse plane are separated by a blocking distance less than the insertion distance and adapted to block the translation of the cap relative to the removal member in a removal direction opposite to the insertion direction.

Abstract: Methods and devices for use and handling of intravenous and/or subcutaneous needles, and, more particularly, to safety devices for shielding needles or other sharp articles or devices that present a safety hazard are disclosed. In an embodiment, a needle protective sheath can include a top wall, a bottom wall, and a pair of side walls joining the top and bottom walls. A finger shield extends from the top wall at a front opening of the sheath and is attached to the top wall by a hinge portion. The finger shield can be rotated about the hinge portion to block the front opening so as to secure a needle within the sheath.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: A safety arrangement for being used in a medicament delivery device, comprising a container holder with a body section and a flange seat and a shell. The container holder is arranged to receive a container with a longitudinal body at one end passing over into a distal flange and at an opposite end passing over into a proximal orifice via a shoulder, such that the distal flanges of the container contacts the flange seat of the container holder. Moreover, the container holder is arranged in the shell such that the container holder is movable in a proximal direction in relation to the shell. A blocking element is arranged between the shell and the container holder. A blocking initiating structure is arranged to reposition the blocking element when the container holder is moved in the proximal direction in relation to the shell from a first position to a second position.

Abstract: The disclosure relates to a sheath removal mechanism (15) for removing a protective needle sheath (5) from a medicament container (3), the medicament container (3) arrangeable in an medicament delivery device (1), wherein the sheath removal mechanism (15) comprises a cap (11) attachable to a distal end of the medicament delivery device (1), wherein the cap (11) comprises at least one ledge (11.6) adapted to engage a protective needle sheath (5).

Abstract: An injector includes a housing, a needle hub movably mounted within the housing and an injection needle supported by the hub. The hub and the needle are axially translatable between retracted and injection positions. A needle shield, having an aperture, is movably connected to the housing between first and second positions. The needle extends through the needle shield aperture in the injection position of the needle and the first position of the needle shield, and the needle is blocked from extending through the needle shield aperture in the second position of the needle shield. When the needle shield is in the second position and the hub and the needle are in the injection position, the needle shield covers the tip of the needle and subsequent movement of the needle shield toward the first position axially translates the hub and the needle back toward the retracted position.

Abstract: The invention provides for a delivery system including a delivery assembly configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new delivery assembly configurations that meet specific needs (i.e., different modes of delivery depending on agent to be delivered, such as subcutaneous, intramuscular, intradermal, intravenous injection, spray, or droplet delivery). The delivery assembly is generally configured to be filled on-site and in the field and is further capable of delivery of the agent in a controlled manner and without requiring specialized skill in administering delivery of such agent.

Abstract: The present disclosure relates to a disposable injection needle, including: a needle mount, having a tube needle; a first sleeve, one end of which is suitable for connecting to the needle mount to form receiving space, and the other end of which is provided with a first opening; a second sleeve, one end of which is located inside the receiving space, and the other end of which having a second opening extends out from the first opening, wherein the second sleeve is axially slideable; an elastic element adapted to allow the second sleeve to move axially toward outside the receiving space, wherein: the second sleeve is provided with a sleeve guiding portion, and the needle mount is provided with a guiding engagement portion, the sleeve guiding portion engages with the guiding engagement portion to guide the circumferential rotation of the second sleeve based on axial movement of the second sleeve toward inside of the receiving space; the first sleeve is provided with a blocking member and the second sleeve is pr

Abstract: A pen needle assembly, comprising an outer cover having an open end, a lid removably connected to the open end of the outer cover, a pen needle disposed in the outer cover, and connecting members disposed on opposite sides of the outer cover. Also disclosed is a pen needle assembly, comprising an outer cover having an open end, a lid removably connected to the open end of the outer cover, a pen needle disposed in the outer cover, and connecting members disposed on opposite sides of the outer cover, wherein a plurality of pen needle assemblies are connected adjacent to each other via the connecting members.

Abstract: In one aspect, a safety pen needle assembly is provided herein which includes a hub with a needle fixed to the hub, the needle having a distal end, formed for insertion into a patient, and a proximal end. The assembly further includes a shield and a biasing member disposed between the hub and the shield configured to urge the shield distally. A protrusion extends from at least one of the hub and the shield with a channel being formed in at least the other of the hub and the shield. The channel is formed to accommodate the protrusion. The shield is movable from a first position to a second position. In the first position, the shield is spaced from the distal end of the needle such that the distal end of the needle is exposed. In the second position, the shield covers the distal end of the needle. The channel guides the protrusion as the shield moves from the first position to the second position. With this arrangement, a shield may be directed to move in a desired path with stability.

Abstract: A medical needle holder (10) having a generally hollow body (18) which extends in the direction of an axis (62) from a first end (20) to a second end (22). The first end is shaped for reception of a needle (50) therein and the second end is open to allow for insertion of a fluid receptacle (16). The first axis is substantially aligned in use with a needle positioned in the first end of the body. The needle holder comprises a grip portion (28) which extends outwardly from the body in a direction which is angularly offset from the first axis. The grip portion may be actuable between an in-use condition and a disposal condition in which the grip portion covers a needle in the needle holder. The body (18) may comprise control formations on its inner surface to allow for control over the insertion of a fluid receptacle (16) into the body.

Abstract: A sterile cover assembly is for a biopsy device. The biopsy device includes a reusable holster including a housing and driving mechanism. The driving mechanism is for driving a cutter in a needle of a probe. The housing is adapted to releasably couple to the probe. The sterile cover assembly includes a sleeve and a flexible sterile cover. The sleeve is configured to receive at least a portion of the housing of the reusable holster. The sterile cover is coupled to the sleeve and is configured to cover the housing of the holster.

Abstract: A drug delivery device for administering a drug is presented having a body, at least one electrical unit and a port for electrically contacting the electrical unit, an adapter for attaching an injection needle to the drug delivery device, a safety mechanism arranged to prevent contacting the electrical unit whilst an injection needle is in fluid communication with the drug delivery device and arranged to prevent establishing a fluid communication whilst the electrical unit is contactable.

Abstract: A drug delivery device includes a housing defining a shell, a drug delivery assembly at least partially disposed within the housing, a cap defining an opening and being adapted to at least partially cover an end of the housing, at least one electronic component, a power source which powers the at least one electronic component, and a switch assembly. The drug delivery assembly comprises a guard which engages an inner surface of the housing and is movable between a first position, a second position, and a third position relative to the housing and is adapted to restrict external contact with a cannula. The switch assembly causes the power source to provide power to the at least one electronic component when the cap is removed from the housing, restrict the power source from providing power when the cap is coupled to the housing and the guard is in the first position, and cause the power source to provide power when the cap is coupled to the housing and the guard is in the third position.

Abstract: A multi-part cap assembly for a drug delivery device is provided, the cap assembly comprising: a first cap component, and a second cap component, wherein the first cap component is assembled to the second cap component, wherein one of the first cap component and the second cap component is provided with a guide track and the other one of the first cap component and the second cap component is provided with a guide feature, wherein the guide track and the guide feature are arranged to cooperate to form an axial guiding interface between the first cap component and the second cap component, and wherein the axial guiding interface is configured such that relative rotational movement between the first cap component and the second cap component is restricted or prevented. Furthermore, a kit for assembling a cap and a method for assembling a cap are provided as well as a drug delivery device.

Abstract: The present invention provides a needle tip protector of a novel structure for an indwelling needle, which enables improvements in safety, etc. as compared with conventional needle tip protectors. A needle tip protector 10 for an indwelling needle includes a tubular peripheral wall 58, and is externally attached over a needle hub 22 of an indwelling needle 16 and moved toward a needle tip 14 side so as to cover the needle tip 14. Detents 74, 74, which are to be detained with the needle hub 22 at a position in a movement of the protector toward the needle tip 14 side of the indwelling needle 16 so as to inhibit backward movement of the protector to the proximal end side of the indwelling needle 16 and to prevent the needle tip 14 from being reexposed, are formed within an inside enclosed by the peripheral wall 58, and are integrally molded with the peripheral wall 58.

Abstract: A needle assembly for percutaneously infusing fluids to a body and/or withdrawing fluids from a body is provided. The needle assembly comprises a polymeric body having a passageway in a proximodistal direction. A wing assembly is secured to the body, and the wing assembly including first and second wings extending laterally in opposite directions from said body. A hollow needle is arranged in said passageway, such that it extends distally from said body, wherein said needle is press fitted or interference fitted in said passageway.

Abstract: Disclosed is a cover for an injector having a needle, a needle cap, and a needle cap remover, the cap remover being a coupler for a needle cap and a user handle, the user handle having a protruding element opposite the coupler, the protruding element having a short dimension and a long dimension, the cover comprising: at least one adhesive layer covering a surface of an outside of the injector; at least one liner layer, covering the adhesive layer, an extension extending beyond the surface; a first aperture through the adhesive layer and the liner layer aligned to an opening in the surface, the first aperture sized and shaped for passage of the coupler therethrough; and a second elongated aperture, through the extension, having a length being shorter than the short dimension and shorter than the long dimension of the protruding element.

Abstract: A safety device for a medicament container includes a first sheath having a first ledge and a second ledge, a second sheath telescopically arranged with the first sheath and releasably coupled to the first ledge, and a finger flange having at least one resilient clip adapted to engage the second ledge first sheath.

Abstract: A medicament delivery device is disclosed having a housing, an actuation mechanism capable of delivering doses of medicament from a medicament container and arranged with a delivery member, a shield, a guard movable within the housing, wherein the guard is operably connected to the actuation mechanism. A protective cap is releasably arranged on the housing and having a shield remover. A blocking element on the guard is movable between a blocking position and a release position and has an engagement surface to engage a proximal area of the housing. The blocking element engages with a surface of the shield remover to retain the blocking element in the blocking position. The engagement surface causes a blocking of the guard from movement and removal of the protective cap enables a movement of the blocking element to a release position when the engagement surface engages the proximal area allowing the member guard to move.

Abstract: A device for transferring fluids in a closed system transfer device using flash for last drop extraction and to reduce coring. The device including a piercing member having a distal end and a proximal end and defining a longitudinal fluid channel. A first opening positioned at the distal end of the piercing member wherein the first opening is in fluid communication with the longitudinal fluid channel. A cover or flash positioned over the first opening. The cover including a pre-cut pattern wherein the cover opens along the pre-cut pattern upon application of a distally directed force from the longitudinal fluid channel. The distal end including the first opening having a steep taper to facilitate last drop extraction.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: The present disclosure relates to a safety mechanism (27) for a medicament delivery device for preventing activation thereof in the event of mechanical shock. The safety mechanism (27) comprises a medicament delivery member sleeve (7), a proximal flange (9) provided at the proximal end of the medicament delivery member sleeve (7), which proximal flange (9) has a first radially flexible arm (9a) extending longitudinally in the distal direction, a housing (3) having a central proximal opening (3a) arranged to receive a distal portion of the medicament delivery member sleeve (7), wherein the medicament delivery member sleeve (7) is axially displaceable inside the housing (3) from an extended position to a retracted position relative to the housing (3), and a cover (5) having a distal opening (5a) forming a channel arranged to receive the medicament delivery member sleeve (7) and the housing (3).

Abstract: A priming assembly for a drug delivery device includes a hub, a base connected to the hub and moveable relative to the hub between a first position and a second position, with the base defining a passageway, a cap defining an interior chamber and a passageway in fluid communication with the interior chamber, and a needle connected to the hub and positioned within the interior chamber of the cap, where the passageway of the base is in fluid communication with the passageway of the cap when the base is in the first position, and where the passageway of the base is isolated from the passageway of the cap when the base is in the second position.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: A medicament delivery device is disclosed having a housing, an actuation mechanism capable of delivering doses of medicament from a medicament container and arranged with a delivery member, a shield, a guard movable within the housing, wherein the guard is operably connected to the actuation mechanism. A protective cap is releasably arranged on the housing and having a shield remover. A blocking element on the guard is movable between a blocking position and a release position and has an engagement surface to engage a proximal area of the housing. The blocking element engages with a surface of the shield remover to retain the blocking element in the blocking position. The engagement surface causes a blocking of the guard from movement and removal of the protective cap enables a movement of the blocking element to a release position when the engagement surface engages the proximal area allowing the member guard to move.

Abstract: A device for generating microbubbles may include a syringe having a barrel, a plunger and a syringe tip; a converging nozzle; and an aerator. The converging nozzle may have a coupling end, a converging tip opposite the coupling end, an exterior mating surface adjacent the converging tip, and an interior channel that fluidly couples the syringe tip and converging tip. The interior channel may have a diameter that progressively decreases from the coupling end to the converging tip. The converging nozzle may be coupled to the syringe tip. The aerator may have a retention end, a discharge end, an interior air chamber, an interior circumferential lip, and a discharge channel at the discharge end. The retention end may be coupled to the converging nozzle. The interior circumferential lip may abut the exterior mating surface. One or more air channels may fluidly couple the discharge channel and the interior air chamber.