Abstract: An apparatus includes a housing, a medicament container and a movable member. The medicament container is configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member. A proximal end portion of the medicament container includes a flange and has a plunger disposed therein. A first shoulder of the movable member is configured to exert the force on the flange to move the medicament container from the first position to the second position. A portion of the first shoulder deforms when the medicament container is in the second position such that at least a portion of the force is exerted upon the plunger. A second shoulder of the movable member is configured to exert a retraction force on the flange to move the medicament container from the second position towards the first position.

Abstract: A safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe, a retaining collar and a rotating collar arranged within the support body. The retaining collar is releasably mounted to the support body. The rotating collar is slidable along an axial length of the support body and rotatable around a central axis of the safety device. The retaining collar is movable with respect to the support body in a proximal direction when the retaining collar is released from being mounted to the support body by the rotating collar.

Abstract: A medicament delivery device comprising a housing, a tubular activation member, a first resilient member, a container holder, a medicament container (80), a tubular operation member (100), a plunger rod (90), a delivery member; wherein the container is a cartridge, having a membrane (82) and in that the delivery member comprises a retainer member (70) fixedly connected to the container holder, a hub (60) coaxially movable within the retainer member, a needle having opposite proximal and distal ends, and a cap (10) interactively connected to the hub and to the retainer member, wherein the cap comprises a distal end surface abutting with the proximal end surface of the annular contact member such that said hub may be distally moved whereby the needle penetrates the membrane and the cap is detached from the retainer member, allowing the tubular activation member to be moved its activated position.

Abstract: The invention relates to a coupling system that can particularly be applied for interfacing a consumable component with a sample chamber to a laboratory instrument for processing a sample fluid. The coupling system comprises a female interface module (10) integrated into the consumable component that has an elastic sealing component (12) with a preformed channel (12a). Moreover, it comprises a male interface module (20) integrated into the instrument and comprising a hollow needle (23) fixed in a first section (22a) of a bush (22), wherein the flexible free end of said needle (23) is partially surrounded by a second section (22b) of the bush that limits the lateral movement of the needle. The diameter of the channel in the sealing component (12) is preferably smaller than the diameter (d) of the needle (23), thus providing an airtight connection and a self-cleaning effect.

Abstract: Provided is a medicament delivery device having an initial locked state, an intermediate priming state, and a medicament delivery state. The medicament delivery device is configured such that individual dose setting and activation of medicament delivery is prevented until the cap at the proximate end of the medicament delivery device is removed.

Abstract: Safety syringes are disclosed, wherein a needle, at least one locking track and at least one tab disposed on an exterior surface of the barrel, wherein the barrel is in fluid communication with the needle, a plunger capable of fitting into the barrel, and a hollow sleeve having a first opening on a first end and a second opening on an opposite end, and having at least one protrusion on an interior surface of the hollow sleeve, wherein the tab on the at least one locking track on the barrel is adapted to engage the at least one protrusion of the hollow sleeve, thereby locking a position of the barrel with respect to a position of the hollow sleeve.

Abstract: A safety sleeve system for syringes and other needle-based devices prevents accidental needle sticks after use of the syringe. The safety sleeve system allows an easy mechanical cover that, once actuated, locks over the exposed needle for safe coverage and disposal, or, in a sterile situation, allows for exposure of a clean needle. The safety sleeve system minimally alters an existing syringe and allows for identical use and function, with only an outer sleeve cover that follows tracks embossed on the exterior of the existing syringe. This sleeve cover can be twisted and locked in an operation position, where the needle extends from the sleeve cover, or in a safety position, where the needle is encased by the sleeve cover.

Abstract: An injection device has a main drive module which can be screwed into the back of a syringe housing to prepare the injector ready for use. The drive module has a firing button and a drive plunger released for forward movement by pressing the firing button. The syringe housing slideably receives a syringe holder whose forward movement is initially prevented by internally directed barbs on a cylindrical latching sleeve. The latching sleeve is acted upon by a release ring on the drive module such that as the drive module is screwed onto the syringe housing, the release ring splays the cylindrical shell to release the syringe carrier for forward movement. The barbs also act as a latch to capture the syringe carrier in its rearward position when the drive module is unscrewed from the syringe housing, which returns the barbs to their initial position before the syringe holder returns to its initial position.

Abstract: The present invention relates to injection devices for injecting a dose of a medicament. The injection device (100) incorporates a housing (101), a needle assembly (150) and a cover (200). The needle assembly (150) comprises an injection needle (152, 153) accommodated in a needle container (151) having an opening which in a storage state of the injection device (100) is sealed by a film seal (155). The cover may include sections (201, 202) arranged movable relative to the housing (101). The injection device (100) is so configured that upon movement of the cover sections (201, 202) relative to the housing (101) the film seal (155) is changed from a sealing state to an unsealing state for shifting the injection device (100) into a ready-to-administer state.

Abstract: The invention relates to a sleeve for an injection device comprising a container having an outer flange, said sleeve being provided with one inner radial projection intended to prevent the proximal movement of said outer flange with respect to said sleeve once said container is received within said sleeve, said sleeve being further provided with one inner longitudinal projection extending distally from said inner radial projection and intended to limit the radial movement of said outer flange, said inner radial projection and inner longitudinal projection being provided on a longitudinal leg connected to said sleeve by a deformable bridge allowing radial deflection of said longitudinal leg outwardly when a distal pressure is exerted on said inner radial projection, and inwardly when a proximal pressure is exerted on said inner radial projection. The invention also pertains to an injection device comprising such a sleeve.

Abstract: The invention relates to a transmission arrangement for controlling a force of a translation, the transmission arrangement comprising a drive collar (13) connectable to a translative drive means (11) and prevented from rotating with respect to a ground (12) of the drive means (11), a flange face of the drive collar (13) bearing against a mating flange face of a friction collar (20), the friction collar (20) slidable in longitudinal direction and rotationally constrained by engagement in a cam track (12.3), another flange face of the friction collar (20) bearing against a mating flange face of a plunger (8), the plunger (8) slidable in longitudinal direction and prevented from rotating.

Abstract: A dual shield mechanism is provided for passive protection of a syringe cannula. The automatic shield system may be used with a re-fillable syringe, and may be adapted for filling the syringe from a vial using a novel vial adapter without triggering the passive shielding mechanism.

Abstract: An injector including a syringe arranged along a longitudinal axis, a removable cover for removable engagement with the syringe and a cover removal assembly including an outer portion which is engagable by a user and is movable axially in a cover disengagement direction along an axial travel path with respect to the longitudinal axis and an inner portion which includes at least one engagement portion which is engagable with the removable cover, whereby axial movement of the inner portion in the cover disengagement direction removes the removable cover from the syringe, at least one of the outer portion and the inner portion being configured such as to provide an axially floating lost motion engagement between the outer portion and the inner portion.

Abstract: An indwelling needle assembly and protector. The indwelling needle assembly has an inner needle, an inner needle hub, an outer needle, an outer needle hub, and a protector for protecting the needle point of the inner needle arranged on the outer periphery of the inner needle so as to be slidable in the axial direction. The protector includes a protecting member in which the needle point of the inner needle is stored and a closing member arranged on the outer periphery of the protecting member so as to be capable of sliding, a displaceable side wall which is capable of being displaced inward so as to close a distal opening of the protecting member, the displaceable side wall being displaced inwardly by the closing member arranged on the outer periphery of the distal end portion of the protecting member.

Abstract: Described is an auto-injector comprising a syringe carrier adapted to contain a syringe. The syringe carrier has a ramp member with a first ramp and a second ramp. The auto-injector comprises a chassis including a resilient beam having a beam head adapted to engage the ramp member. The first ramp is adapted to deflect the beam head in a radial direction relative to the chassis and the second ramp is adapted to deflect the beam head in a tangential direction relative to the chassis.

Abstract: A syringe cradle for holding a syringe, the syringe cradle comprising a syringe holder at a proximal end for engaging a barrel of a syringe and a rider for pressing on a plunger of the syringe, a cylindrical body for surrounding the syringe, a distal cap for closing a distal end of the cylindrical body, a stepwise advancing mechanism for advancing the rider along the cylindrical body towards the proximal end, and a stopping mechanism to prevent the rider from moving backwards towards the distal end of the cylindrical body.

Abstract: A holder with a safety shield for a drug delivery device; the shield obstructing access to a needle of the drug delivery device following use thereof. The safety shield may be actively deployed, in which case the health care worker must perform an action beyond complete depression of the pusher into the body of the drug delivery device to deploy the shield. Alternatively, the safety shield may be deployed passively or automatically, in which case deployment of the shield occurs upon complete depression of the pusher into the body, with no additional action required of the health care worker. The safety shield is spring-loaded and released to its extended position by a mechanical coupling of a series of position members, including levers, formed on the holder and the drug delivery device.

Abstract: Cover (25) for housing a syringe (1), comprising: a shell (30) extending along a longitudinal axis (B) and adapted to accommodate a body (2), a finger grip (4) and a piston rod (10) of the syringe (1) so that at least a part of a needle of the syringe (1) extends through the shell (30), an actuator (26) moveably mounted on the shell (30), wherein the shell (30) is provided with a holding member (48) adapted to hold the finger grip (4) of the syringe (1), and wherein the shell (30) comprises a base (40) and a lid (55), said base (40) including a cavity extending along the longitudinal axis (B) of the shell (30) and adapted to receive the syringe (1), said lid (55) being movable with respect to the base (40) between an opened position in which the shell (30) presents a lateral access to the cavity, and a closed position.

Abstract: A medication administering device, to which a preparation syringe containing a preparation is mounted, and which administers a preparation to a living body, and comprises a main body; a cylindrical syringe holder that is provided to the main body and into which the preparation syringe is inserted from the rear end side; a cylindrical syringe cover that supports the preparation syringe on the inner peripheral face side, and into which the preparation syringe is inserted from the distal end side; an inner case that guides the syringe cover and is removably fitted together with the syringe cover; and a distal end cap that guides the main body and is removably fitted together with the main body, and moves in conjunction with the syringe cover during attachment to the main body.

Abstract: According to the invention, an injection device (D) comprises a pre-filled syringe and a safety device. The pre-filled syringe comprises a barrel with an inner cavity in fluid communication with a hypodermic needle attached to a distal end of the pre-filled syringe and a piston fluid-tightly sealing a proximal end of the inner cavity. The safety device comprises a support body for retaining the pre-filled syringe therein, an outer body operably connected to the piston, a needle shield and a releasable retaining means (R). The retaining means comprises a radial projection and a longitudinal recess adapted to receive the radial projection. The radial projection is connected to or integral part of one of the support body or the outer body and a longitudinal recess formed into the other of the support body or the outer body. The needle shield, the support body and the outer body are telescopable relative to each other.

Abstract: The present invention provides for an autoinjector that registers off a distal end of a syringe to provide for a more accurate needle insertion depth. The autoinjector employs an automatically deployable frontal buttress for registration of the distal end or shoulder of the syringe.

Abstract: The present invention provides for an injection device including a syringe with a proximal end, a distal end, a needle extending from the distal end, and a plunger inserted into the proximal end. A guard is slidable on the syringe, has a proximal end, a distal end, and is biased from a first position wherein the needle is exposed towards a second position wherein the guard covers the needle. The injection device includes first and second sets of cooperating detents for retaining the guard and syringe in the first and second positions, respectively. A latch member extends proximally from the guard that is engageable by the plunger as the plunger is depressed to release the first set of cooperating detents. Upon release, a spring element biases the guard towards the second position until the second set of cooperating detents engage and secure the guard in the second position.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: An injector assembly (100) includes a main body (102) having a first connecting arrangement, and a cap (104) having a second connecting arrangement for, in use, releasably connecting the cap to the first connecting arrangement of the main body. The first or the second connecting arrangement (120) includes an open neck portion (122) leading to a locating portion (124), at least part of the locating portion having a maximum width (120A) greater than a maximum width (120B) of the open neck portion. The second of the first connecting arrangement (108), respectively, includes a head portion (109) having a maximum width (108A) greater than the maximum width of the open neck portion.

Abstract: A cap assembly for a drug delivery device is present having a cap body to protect and to receive a distal dispensing end of the drug delivery device, an interlock member operably engaged with the cap body and being further adapted to releasably engage with a distal end section of the device's dispensing end to provide a safety lock for the cap body.

Abstract: The present invention relates to an auto injector, e.g. a disposable auto injector, that can be safely operated for automatic injection of a dose of medication by the recipient of the medication, having a housing for accommodation of a container with at least one compartment for accommodation of a medicament to be injected and a needle mounting site for user mounting of a needle covered by a needle cap before injection, and a needle shield that is accommodated in the housing in a retracted position before mounting of the needle and that is configured to be automatically moved forward to a protruded position by a needle shield driver upon mounting of the needle and removal of the needle cap.

Abstract: An injection device comprises a housing adapted to receive a fluid container having a discharge nozzle and a dispensing piston moveable in the fluid container to expel the contents of the fluid container out of the discharge nozzle. A drive is adapted on activation to act on the fluid container to advance it from a retracted position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle extends from the housing and act on the dispensing piston to expel the contents of the fluid container out of the discharge nozzle. A connector is adapted to receive a vial containing fluid and connect it to the discharge nozzle.

Abstract: An injection device comprises a syringe extendible against a spring bias from a retracted position in a housing to a projecting injecting position. A spring biased plunger has collapsible elbows which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung.

Abstract: An injection device has a container holder in a medicament container housing; first and second energy accumulating members in the housing; a slidable sleeve; a plunger holder associated with the first energy accumulating member such that the plunger holder and container holder are axially movable toward a proximal end of the device from an initial position to a position following needle penetration; and a plunger rod operationally associated with the second energy accumulating member such that the plunger rod is axially movable toward the proximal end from a locked position to a position following medicament injection. In the initial position, movement of the plunger holder is inhibited by interaction of a first biasable member with the plunger holder, the first biasable member recoiling when overlapped by an opening and/or recess of the sleeve such that the plunger holder is released.

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: A folding panel needle guard comprises front and rear panels coupled together at hinges, a collar attached to the front panels at hinges, a guard base element coupled to the rear panels at hinges, a hub and a spring to unfold and lock the front and rear panels in a co-linear needle shielded configuration. The folding panel needle guard is mountable to a needle or syringe assembly.

Abstract: Described is an injection device for administering a dose of a medicament comprising a case having a proximal end and a distal end, a carrier adapted to accommodate a syringe, and a trigger button. In a first state, the trigger button is coupled to the case and/or the carrier and abuts the distal end of the case. In an intermediate state, the case moves proximally relative to the carrier and the trigger button, and the trigger button engages the carrier. In a second state, the trigger button and the carrier move proximally relative to the case, and the trigger button disengages the carrier and engages the case.

Abstract: Provided is a medicament delivery device having an initial locked state, an intermediate priming state, and a medicament delivery state. The medicament delivery device is configured such that individual dose setting and activation of medicament delivery is prevented until the cap at the proximate end of the medicament delivery device is removed.

Abstract: A medication administering device has mounted thereto a preparation syringe containing a preparation and comprises a substantially cylindrical syringe cover that supports the preparation syringe on the inner peripheral face side, a piston that presses on the rear end of the preparation syringe, and a piston case that surrounds the piston, that guides the outer peripheral face of the syringe cover in the direction of the piston on the substantially cylindrical inner peripheral face side, and that is mounted in a state in which the syringe cover is removable. The medication administering device comprises a syringe holder that guides the outer peripheral face of the preparation syringe in the direction of the piston on the cylindrical inner peripheral face side, and whose outer peripheral face is removably fitted together with the inner peripheral face of the syringe cover.

Abstract: A reloadable auto injector wherein a syringe assembly is movably positioned between a first position in which the needle is accommodated inside a housing and a second position in which the needle protrudes outside the housing. The assembly comprises a syringe, a plunger rod and a plunger rod driver configured to apply a force to the plunger rod to advance the plunger rod in the syringe for delivering at least one dose of medicament. A syringe driver is configured to apply a force to the assembly thereby moving the assembly from the first position to the second position. A reload handle may be connected to the assembly so that user operation of the reload handle retracts the assembly to the first position and simultaneously reload the syringe driver to thereby ready the auto injector for delivering a further dose of medicament. The plunger rod driver is not re-activated.

Abstract: A drug injection device includes a main body case having an injection needle let-in/let-out opening, a drug syringe mounting component that is provided inside the main body case and in which a drug syringe is mounted, a piston that is movable with respect to the drug syringe mounting component, a drive mechanism that drives the piston, a controller that is electrically connected to the drive mechanism, and an acceleration sensor that is electrically connected to the controller. This drug injection device allows the injection of a drug to be carried out safely and properly.

Abstract: The invention relates to a needle safety device for a medical device, the needle safety device comprising: a base portion having a bore extending in an axial direction therethrough for receiving a needle; and first and second opposing jaws extending from the base portion generally in the axial direction, wherein at least a portion of the second jaw is formed from a separate structural member connected to the base portion, wherein said portion of the second jaw is deflectable with respect to the first jaw in order to allow a needle received in the bore of the base portion to extend all the way through the needle safety device.

Abstract: The invention comprises a syringe body (10) having a distal end (10B) fitted with an injection needle (14), at least one sheath (16, 18) inside which the body is positioned, and a protective cap (40) able to be retained relative to the syringe body (10) to cover the needle (14) and be separate from this body to release the needle. The device comprises a non-return unit (50) able to oppose a refitting of the cap (40) in its protection position once the needle has been released. This non-return unit, for example, comprises an elastic lip (50) joined to the sheath or the cap.

Abstract: Exemplary embodiments provide wearable automatic injection devices for administering a therapeutic agent to a patient's body at fast, controlled rates, for example, in a single fast bolus. Exemplary embodiments also provide methods for assembling wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates. Exemplary embodiments also provide methods for using wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates.

Abstract: A key-shaped portable injector for delivering a dose of medication, the injector preferably including a cap, a body having an internal cavity, a syringe or cartridge with an attached needle within the internal cavity, a protective sleeve, an activation mechanism and a safety mechanism wherein the injector is reconfigurable from a first, non-deployed configuration where the activation mechanism, syringe or cartridge and a safety mechanism are all in a first position with respect to the body to a second, deployed configuration where the safety mechanism, activation mechanism, and syringe or cartridge are all in a second position with respect to the body and to a third, depleted configuration where the activation mechanism is back to its first position and a protective sleeve is in its second position.

Abstract: A portable medicament dispensing device having a mechanism which is not susceptible to jamming for dispensing the medication to a user. The device employs a coupling for coupling the relative motion between reciprocating body members housing the ancillary components and a barrel plunger associated with the syringe. One embodiment provides a pivoting coupling whereas an alternate uses a rack and pinion system. The advantage of simplifying such mechanisms results in a structure which has smooth unencumbered motion with fewer parts to avoid mechanical jamming during use.

Abstract: A combined container-syringe includes a body that has an outer tube to be filled with a drug solution. A cylindrical tip is attached to a front end portion of the outer tube and to a front end portion of which an injection needle is attached. A cylindrical safety device is attached on an outer circumferential surface of the outer tube in a freely sliding manner. A first retaining member fixes the safety device in a disengageable manner at a first position where the safety device is separated from the injection needle. A second retaining member fixes the safety device at a second position where the safety device covers the injection needle. A biasing member biases the safety device in the direction from the first position to the second position. A latch releasing member releases the engagement by the first retaining member.

Abstract: A product container holder for accommodating a product container, wherein the product container holder can be separately handled and can be inserted into an injection device, and includes an engaging member that can be moved transversely to the longitudinal axis of the product container holder and which can block a movement of the product container relative to the product container holder in the distal direction, and a securing structure which can be moved relative to the engaging member from an initial position to a securing position in which it restricts the mobility of the engaging member. In some embodiments, a method of making and a method of using the product container holder is encompassed, as is a container and an injection device with which the holder can be used.

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments are delivered through a single hollow needle (5). The medicated module (4) is user selectable so that it will deliver both the primary (1) and secondary medicaments (2), or only the primary medicament (1). The module (4) also contains a guard (42) that locks after dose delivery.

Abstract: The present invention relates to an injection device (1) comprising: -a body (3) receiving a product, having a needle (7) and a piston (5) attached to a piston rod (8) movable between a storage position and an end-of-injection position, -a sleeve (6) for protecting the needle (7), movable between an initial position, where the needle (7) is uncovered, and a final position, where the needle (7) is covered, -biasing means (26) for moving said sleeve (6) from its initial position to its final position, -immobilization means (16, 31) for keeping said sleeve (6) in its initial position, characterized in that: -said piston rod (8) comprises a first portion (9) and a second portion (10), said second portion (10) being able to switch between a locked position, in which said second portion (10) is fixed to said first portion (9) and an unlocked position, in which said second portion (10) is movable with respect to said first portion on a predetermined distance along the longitudinal axis of said piston rod (8).

Abstract: A safety device for a pre-filled syringe is proposed that comprises a hollow support body with a helical groove formed into an inner surface thereof, a mounting collar for mounting the pre-filled syringe to the support body, a spinning collar with a helical tongue formed to an outer surface thereof and a torsion spring. The helical groove accommodates the helical tongue. Upon release, the torsion spring is capable of exerting a torque upon the spinning collar which causes the spinning collar to rotate within the support body. The engagement of the helical groove and the helical tongue redirects the rotational movement of the spinning collar to a translatory movement that moves the mounting collar in a proximal direction.

Abstract: An autoinjector includes a body (10, 12), a syringe carrier (34) supporting a syringe (13) or cartridge with a needle at its forward end, for movement from a rearward position to a forward position to extend a needle, the syringe or cartridge having a barrel of generally cylindrical form having at a forward region thereof a forward facing abutment surface, wherein the syringe carrier is provided with a retention surface arranged to cooperate with the forward facing abutment surface on the syringe to prevent or limit forward movement of the syringe relative to the syringe carrier, the autoinjector further including a removable needle shield (15) releasably attached to the syringe or cartridge and shrouding the needle, a cap (14) attached to the forward end of the body and forwardly removable, the cap having a removal surface for engaging the needle shield whereby removal of the cap removes the needle shield.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a guide pin, a guide track and a cut-out adjacent to the guide track. The guide pin protrudes into the guide track and moves within and along the guide track when the needle shield is slid relative to the support body. The cut-out allows a side wall of the guide track to be deflected in a lateral direction perpendicular to a central axis of the safety device.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body for mounting the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a flexible arm with a guide pin, a guide track and a separating wall. The guide pin extends from the flexible arm in a radial direction, and protrudes into the guide track. The separating wall extends into the guide track in a direction parallel to a central axis of the safety device. When the needle shield is slid relative to the support body the guide pin moves along the guide track to deflect the flexible arm in a lateral direction perpendicular to the central axis and the movement of the guide pin along the guide track is guided by the interplay of the flexible arm and the separating wall.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end, operating the syringe to supply the dose of medicament, and retracting the syringe with the needle into the covered position after delivering the medicament, activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.